8,629 results match your criteria Toxicity Mercury

Mercury stress tolerance in wheat and maize is achieved by lignin accumulation controlled by nitric oxide.

Environ Pollut 2022 May 18:119488. Epub 2022 May 18.

Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Key Laboratory of Regulating and Controlling Crop Growth and Development Ministry of Education, Henan Agricultural University, Zhengzhou, Henan, 450046, China.

Nitric oxide (NO) is an important phytohormone for plant adaptation to mercury (Hg) stress. The effect of Hg on lignin synthesis, NO production in leaf, sheath and root and their relationship were investigated in two members of the grass family - wheat and maize. Hg stress decreased growth and lignin contents, significantly affected phenylpropanoid and monolignol pathways (PAL, phenylalanine ammonia-lyase; 4-coumarate: CoA ligase, 4CL; cinnamyl alcohol dehydrogenase, CAD), with maize identified to be more sensitive to Hg stress than wheat. Read More

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Differential toxicity of potentially toxic elements to human gut microbes.

Chemosphere 2022 May 17:134958. Epub 2022 May 17.

Global Centre for Environmental Remediation, University of Newcastle, Callaghan, Australia.

Specific microorganisms in the human gut (i.e., gut microbes) provide mutually beneficial outcomes such as microbial balance by inhibiting the growth of pathogenic organisms, immune system modulation, fermentation of ingested products, and vitamin production. Read More

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Tattoo inks are toxicological risks to human health: A systematic review of its ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.

Toxicol Ind Health 2022 May 19:7482337221100870. Epub 2022 May 19.

Photobiology Laboratory, Systems Toxicology and Health Risk Assessment Group, 538266CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, India.

Today, tattooing has become very popular among people all over the world. Tattooists, with the help of tiny needles, place tattoo ink inside the skin surface and unintentionally introduce a large number of unknown ingredients. These ingredients include polycyclic aromatic hydrocarbons (PAHs), heavy metals, and primary aromatic amines (PAAs), which are either unintentionally introduced along with the ink or produced inside the skin by different types of processes for example cleavage, metabolism and photodecomposition. Read More

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Mercury toxicity affects oxidative metabolism and induces stress responsive mechanisms in wheat ( L.).

Physiol Mol Biol Plants 2022 Apr 7;28(4):911-920. Epub 2022 Apr 7.

Department of Molecular Biology and Genetics, Faculty of Science, Bartın University, 74100 Bartın, Turkey.

Mercury (Hg) toxicity is an increasing problem worldwide, with a negative impact on the environment and living organisms including both animals and plants. In this study, we analyzed molecular and biochemical changes related to Hg toxicity in wheat ( L.) seedlings. Read More

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A novel peptide-based fluorescent probe for highly selective detection of mercury (II) ions in real water samples and living cells based on aggregation-induced emission effect.

Anal Bioanal Chem 2022 May 20. Epub 2022 May 20.

Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Shida Road 1#, Nanchong, 637009, People's Republic of China.

A new fluorescent probe TPE-GHK was synthesized containing a tetrastyrene (TPE) derivative as fluorophore and classical tripeptide (Gly-His-Lys-NH) as a receptor based on the aggregation-induced emission (AIE) mechanism. TPE-GHK displayed high selectivity and rapid fluorescent "turn-on" response to Hg among other competitive metal ions. The 2:1 complex binding mechanism of TPE-GHK toward Hg was verified by fluorometric titration, Job's plots, and ESI-HRMS spectra. Read More

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Molecular Fates of Organometallic Mercury in Human Brain.

ACS Chem Neurosci 2022 May 11. Epub 2022 May 11.

Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, Saskatchewan S7N 5B3, Canada.

Mercury is ubiquitous in the environment, with rising levels due to pollution and climate change being a current global concern. Many mercury compounds are notorious for their toxicity, with the potential of organometallic mercury compounds for devastating effects on the structures and functions of the central nervous system being of particular concern. Chronic exposure of human populations to low levels of methylmercury compounds occurs through consumption of fish and other seafood, although the health consequences, if any, from this exposure remain controversial. Read More

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Seasonal trends of mercury bioaccumulation and assessment of toxic effects in Asian clams and microbial community from field study of estuarine sediment.

Environ Res 2022 May 7;212(Pt C):113439. Epub 2022 May 7.

Department of Environmental Engineering, Korea University Sejong Campus, 2511 Sejong-ro, Sejong City, 30019, Republic of Korea. Electronic address:

This study investigated seasonal trends in bioaccumulation potential and toxic effects of mercury (Hg) in Asian clams (Corbicula fluminea) and microbial community. For this, a clam-exposure experiment was performed during summer, fall, and winter seasons in four different sites (HS1: control/clean site; HS2, HS3, and HS4: contaminated sites) of Hyeongsan River estuary, South Korea. Total mercury (THg) and methylmercury (MeHg) in whole sediments were highest at HS4 site during fall, sustained similar levels during winter, but decreased during summer. Read More

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Hg(II) sensing, catalytic, antioxidant, antimicrobial, and anticancer potential of Garcinia mangostana and α-mangostin mediated silver nanoparticles.

Chemosphere 2021 Jun 28;272:129794. Epub 2021 Jan 28.

Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar, 25000, Khyber Pakhtunkhwa, Pakistan.

This study reports synthesis of Garcinia mangostana fruit pericarp (unwanted waste material) and α-mangostin mediated silver nanoparticles (AgNPs). These AgNPs were efficiently produced using 1:10 (extract and salt) ratio under stirring and heating, which was confirmed by surface plasmon resonance (SPR) band in UV-Visible spectroscopic analysis, and size of 73-91 nm determined by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The synthesized AgNPs were used for Hg(II) detection in tap water, where the limits of detection and quantification were 2. Read More

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An Study to Compare the Release of Fluoride from Glass Ionomer Cement (Fuji IX) and Zirconomer.

Int J Clin Pediatr Dent 2022 Jan-Feb;15(1):35-37

Department of pedodontics and preventive dentistry, Rungta college of Dental Science and Research Center, Bhilai, Chhattisgarh, India.

Mercury toxicity from amalgam dental fillings and their potential for creating problems in the environment and for human health have prompted the development of new restorative materials. The leading alternatives among these are glass ionomer cements. According to current understanding, restorative materials that slowly release fluoride exert a local cariostatic effect. Read More

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Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal neurons.

J Toxicol Sci 2022 ;47(5):211-219

Department of Basic Medical Sciences, National Institute for Minamata Disease.

Methylmercury (MeHg), an environmentally toxic substance, causes site-specific neuronal cell death; while MeHg exposure causes death in cerebrocortical neurons, interestingly, it does not in hippocampal neurons, which are generally considered to be vulnerable to toxic substances. This phenomenon of site-specific neuronal cell death can be reproduced in animal experiments; however, the mechanism underlying the resistance of hippocampal neurons to MeHg toxicity has not been clarified. In this study, we comparatively analyzed the response to MeHg exposure in terms of viability and the expression characteristics of primary cultured cerebrocortical neurons and hippocampal neurons derived from fetal rat brain. Read More

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Removal of micropollutants by UASB reactor and post-treatment by Fenton and photo-Fenton: Matrix effect and toxicity responses.

Environ Res 2022 May 5;212(Pt C):113396. Epub 2022 May 5.

Research Group on Water and Wastewater Advanced Treatment Technologies (GPTec), Department of Chemistry and Biology, Federal University of Technology-Paraná (UTFPR), Deputado Heitor de Alencar Furtado St., 5000, Ecoville, Curitiba, Paraná, 81280-340, Brazil. Electronic address:

Literature is scarce on the performance of Fenton-based processes as post-treatment of municipal wastewater treated by upflow anaerobic sludge blanket (UASB) reactor. This study aims to perform Fenton and photo-Fenton from UASB influent and effluent matrices to remove micropollutants (MPs) models: atrazine (ATZ), rifampicin (RIF), and 17α-ethynylestradiol (EE2). A UASB reactor at bench-scale (14 L) was operated with these MPs, and the AOPs experiments at bench-scale were performed on a conventional photochemical reactor (1 L). Read More

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Toxicological risk of mercury for fish and invertebrate prey in the Arctic.

Sci Total Environ 2022 May 4;836:155702. Epub 2022 May 4.

Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Québec, Canada.

We assessed the risks of mercury (Hg) to Arctic marine and freshwater fish by compiling published muscle Hg concentrations and information on tissue concentrations associated with adverse effects. The assessment included 333 groups of fish representing 35 genera and 14,002 individuals sampled from sites across the circumpolar Arctic. Mean or median Hg concentrations in fish muscle varied widely from 0. Read More

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Dose-dependent interaction of two heavy metals with amiodarone toxicity in .

Toxicol Ind Health 2022 May;38(5):249-258

63572Lebanese University, FS1, Rafic Hariri Campus, Beirut. Lebanon.

Amiodarone (AMD) is an antiarrhythmic drug that induces idiosyncratic toxicity. Environmental pollutants, including heavy metals, could interact with its toxicity by affecting pharmacokinetics and pharmacodynamics. Other levels of interaction could exist in yeast, such as oxidative stress and the general stress response. Read More

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Differential Detection of Bioavailable Mercury and Cadmium Based on a Robust Dual-Sensing Bacterial Biosensor.

Front Microbiol 2022 13;13:846524. Epub 2022 Apr 13.

Department of Pathology and Toxicology, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China.

Genetically programmed biosensors have been widely used to monitor bioavailable heavy metal pollutions in terms of their toxicity to living organisms. Most bacterial biosensors were initially designed to detect specific heavy metals such as mercury and cadmium. However, most available biosensors failed to distinguish cadmium from various heavy metals, especially mercury. Read More

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A novel coumarin-based colorimetric and fluorescent probe for detecting increasing concentrations of Hg and .

RSC Adv 2021 Jul 5;11(38):23597-23606. Epub 2021 Jul 5.

Department of Pharmacy, Haidian Maternal & Child Health Hospital of Beijing Beijing 100080 PR China

Mercury has complex biological toxicity and can cause a variety of physiological diseases and even death, so it is of great importance to develop novel strategies for detecting trace mercury in environmental and biological samples. In this work, we designed a new coumarin-based colorimetric and fluorescent probe CNS, which could be obtained from inexpensive starting materials with high overall yield in three steps. Probe CNS could selectively respond to Hg with obvious color and fluorescence changes, and the presence of other metal ions had no effect on the fluorescence changes. Read More

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Comparative chemical analysis, mutagenicity, and genotoxicity of Petroleum refinery wastewater and its contaminated river using prokaryotic and eukaryotic assays.

Protoplasma 2022 Apr 25. Epub 2022 Apr 25.

Department of Biology, Federal University of Technology, Akure, Ondo State, Nigeria.

Concern on the toxicity of final wastewater generated by the petroleum refining industry has increased in recent years due to the potential health threats associated with their release into the waterways. This study determined the mutagenic and genotoxic potential of petroleum refinery wastewater and a receiving river using the Ames fluctuation test on Salmonella typhimurium strains TA100 and TA98, SOS chromotest on Escherichia coli PQ37, and piscine peripheral micronucleus (MN) assay. Analyses of the physicochemical parameters, heavy metal, and organic contents of the samples were also performed. Read More

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Toxic metals that interact with thiol groups and alteration in insect behavior.

Curr Opin Insect Sci 2022 Apr 21:100923. Epub 2022 Apr 21.

Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Toxic metals, such as mercury (Hg), lead (Pb), cadmium (Cd), and copper (Cu) are widespread in the biosphere, and human activities have contributed to their continuous release into the ecosystems. Metal-induced toxicity has been extensively studied in mammals; however, the effects of these metals on insects' behavior have been explored to far lesser degree. As the main mechanism of toxicity, the cationic metals, explored in this review, have high affinity for thiol-containing molecules, disrupting the function of several proteins and low-molecular weight thiol-containing molecules. Read More

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Accumulation of the Toxic Metal Mercury in Multiple Tissues of Marine-Associated Birds from South Florida.

Arch Environ Contam Toxicol 2022 May 22;82(4):493-505. Epub 2022 Apr 22.

Halmos College of Arts and Sciences, Nova Southeastern University, 8000 North Ocean Drive, Dania Beach, FL, 33004, USA.

One of the best studied global "hot spots" for ecological mercury (Hg) contamination is south Florida (USA), where elevated Hg concentrations in environmental media and regional wildlife were first described over thirty years ago. While Hg contamination has lessened in this region, it is still critical to monitor Hg uptake and potential risks in south Florida wildlife, especially in marine-associated birds, which are known to accumulate potentially toxic Hg levels. In this study, total Hg (THg) concentrations were measured in liver, kidney, muscle, and feathers of 101 individuals from seven species of south Florida birds: brown pelican Pelecanus occidentalis, double-crested cormorant Phalacrocorax auratus, herring gull Larus argentatus, laughing gull Leucophaeus atricilla, northern gannet Morus bassanus, royal tern Thalasseus maximus, and osprey Pandion halietus. Read More

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Comparative Toxicity of Interferon Beta-1a Impurities of Heavy Metal Ions.

Dmitriy Berillo

Medicina (Kaunas) 2022 Mar 23;58(4). Epub 2022 Mar 23.

Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan.

: Providing a proper quality control of drugs is essential for efficient treatment of various diseases minimizing the possible side effects of pharmaceutical active substances and potential impurities. Recent in vitro and in vivo studies have shown that certain heavy metalloids and metals interfere with protein folding of nascent proteins in cells and their biological function can be altered. It is unknown whether the drug impurities including heavy metals may affect the tertiary protein structure. Read More

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Mercury and cancer: Where are we now after two decades of research?

Food Chem Toxicol 2022 Apr 18;164:113001. Epub 2022 Apr 18.

Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, Moscow, 119146, Russia; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003, Yaroslavl, Russia. Electronic address:

The present study aims to review epidemiological and experimental toxicology studies published over the last two decades linking mercury (Hg) exposure and carcinogenesis, with a special emphasis on the potential underlying mechanisms. While some epidemiological studies have observed a strong association between environmental/occupational Hg exposure levels, measured in blood, toenail, and hair, and cancer risk and mortality, others failed to reveal any association. In experimental models, high-dose Hg exposure has been linked with cytotoxicity, whereas low-dose exposure was posited to induce proliferative responses in both normal and cancerous cells by interference with estrogen receptor, ERK1/2, JNK, NADPH-oxidase and, potentially, Nrf2 signaling. Read More

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Sub-chronic oral toxicity evaluation of herbo-metallic formulation Arshakuthar rasa in rats.

J Ethnopharmacol 2022 Apr 17:115306. Epub 2022 Apr 17.

Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, Telangana, India. Electronic address:

Ethnopharmacological Relevance: Arshakuthar Rasa (AR) is a mercury based Ayurvedic herbo-metallic formulation. The concerns are being raised about the probable toxicity of mercury after prolonged use of AR. Hence, there is need for a long-term repeated in vivo toxicity study. Read More

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Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4'-dimethylaminochalcone.

J Fluoresc 2022 Apr 20. Epub 2022 Apr 20.

Instituto de Química, Facultad de Química, Pontificia Universidad Católica de Valparaíso, Av. Universidad #330, Curauma, Valparaíso, Chile.

Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone (2E)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (8) and assessed its photophysical properties. Read More

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Mercury, selenium, and fatty acids in the axial muscle of largemouth bass: evaluating the influence of seasonal and sexual changes in fish condition and reproductive status.

Ecotoxicology 2022 Apr 19. Epub 2022 Apr 19.

Division of Community and Public Health, Missouri Department of Health and Senior Services, Bureau of Environmental Epidemiology, Jefferson City, MO, USA.

Largemouth bass (LMB, 265-475 mm) were collected to document whether changes in fish condition and reproductive status influenced the concentration of total mercury (Hg) and selenium (Se) in axial muscle by season and sex. The fatty acid (FA) composition of fish was also examined to describe seasonal and sexual differences and identify whether arachidonic acid (ARA) could be used as a biomarker of Hg toxicity. There was a trend for females to have lower (p < 0. Read More

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Conjoint application of novel bacterial isolates on dynamic changes in oxidative stress responses of axenic Brassica juncea L. in Hg-stress soils.

J Hazard Mater 2022 07 6;434:128854. Epub 2022 Apr 6.

Laboratory of Applied Microbiology, Department of Environmental Science & Engineering, Indian Institute of Technology, Indian School of Mines, Dhanbad 826 004, Jharkhand, India.

This experimental study explores the possible role of three Hg-resistant bacterial strains in the enhanced growth of the mustard plant (Brassica juncea) under Hg-stress conditions. Under different concentrations of Hg, a pot scale experiment with Brassica juncea L. was performed to investigate the potential of bacterial strains for phytoremediation under Hg stress conditions. Read More

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Interplay of Obesity, Ethanol, and Contaminant Mixture on Clinical Profiles of Cardiovascular and Metabolic Diseases: Evidence from an Animal Study.

Cardiovasc Toxicol 2022 Jun 16;22(6):558-578. Epub 2022 Apr 16.

Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, HPFB, Health Canada, Ottawa, ON, Canada.

Obesity, ethanol, and contaminants are known risk factors of cardiovascular and metabolic diseases (CMD). However, their interplay on clinical profiles of these diseases remains unclear, and thus were investigated in this study. Male lean or obese JCR rats were given water or 10% ethanol and orally treated with or without a contaminant mixture (CM) dissolved in corn oil and loaded on two cookies at 0, 1. Read More

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Levels of non-essential trace metals and their impact on placental health: a review.

Environ Sci Pollut Res Int 2022 Apr 15. Epub 2022 Apr 15.

Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000, Belgrade, Serbia.

According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Read More

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Environmentally relevant concentrations of mercury inhibit the growth of juvenile silver carp (Hypophthalmichthys molitrix): Oxidative stress and GH/IGF axis.

Ecotoxicol Environ Saf 2022 May 11;236:113484. Epub 2022 Apr 11.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China; Fishery Resources and Environmental Science Experimental Station of The Upper-Middle Reaches of Yangtze River, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Science, Wuhan 430223, China. Electronic address:

Mercury (Hg) is a global environmental contaminant, and excessive mercury levels in water can adversely affect the growth of fish. Silver carp (Hypophthalmichthys molitrix) is one of the important freshwater aquaculture fish in China, and its natural resources have been critically declining. However, the effects of Hg exposure on the growth hormone/insulin-like growth factor (GH/IGF) axis and its toxic mechanism are still unclear. Read More

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Enhanced mercury reduction in the South Atlantic Ocean during carbon remineralization.

Mar Pollut Bull 2022 May 9;178:113644. Epub 2022 Apr 9.

Department of Environmental Sciences, Jožef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia; Jožef Stefan International Postgraduate School, Jamova cesta 39, 1000 Ljubljana, Slovenia.

Mercury (Hg) in seawater is subject to interconversions via (photo)chemical and (micro)biological processes that determine the extent of dissolved gaseous mercury (DGM) (re)emission and the production of monomethylmercury. We investigated Hg speciation in the South Atlantic Ocean on a GEOTRACES cruise along a 40°S section between December 2011 and January 2012 (354 samples collected at 24 stations from surface to 5250 m maximum depth). Using statistical analysis, concentrations of methylated mercury (MeHg, geometric mean 35. Read More

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Comprehending The Role of Endocrine Disruptors In Inducing Epigenetic Toxicity.

Endocr Metab Immune Disord Drug Targets 2022 Apr 11. Epub 2022 Apr 11.

Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, Chennai - 603 203.

Endocrine disruptors are natural or man-made chemicals that interfere with the body's endocrine system leading to defects in hormone synthesis and production. These chemicals are categorized as plasticizers and cosmetic chemicals, heavy metals, phytoestrogens, pesticides, detergents, surfactants, and flame retardants. Some of the most common endocrine disruptors are dioxins, bisphenol A, phthalates, perchlorate, perfluoroalkyl, and polyfluoroalkyl substances (PFAs), phytoestrogens, polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCB), triclosan, atrazine, lead, arsenic, mercury, organophosphate pesticides, and glycol ethers. Read More

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Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after Maternal Exposure.

Int J Mol Sci 2022 Mar 29;23(7). Epub 2022 Mar 29.

Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.

Methylmercury (MeHg) is one of the most dangerous toxic pollutants spread throughout the earth. Chronic MeHg intoxication by contaminated food ingestion is the most common threat to human health, including impairment to the developing fetus. The present study aims at investigating the effects of maternal exposure to MeHg during gestation and lactation on the spinal cord of offspring. Read More

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