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Mol Cell Biochem 2022 May 22. Epub 2022 May 22.

Department of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON, K1S 5B6, Canada.

Lithium chloride (LiCl) is a widely used and extensively researched drug for the treatment of bipolar disorder (BD). As a result, LiCl has been the subject of research studying its toxicity, mode of action, and downstream cellular responses. LiCl has been shown to influence cell signaling and signaling transduction pathways through protein kinase C and glycogen synthase kinase-3 in mammalian cells. Read More

Toxicol Lett 2022 May 17. Epub 2022 May 17.

Department of Pharmacology, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China. Electronic address:

Epidemiological research suggests that convulsions may have an intrauterine developmental origin related to the application of dexamethasone, an artificially synthesized glucocorticoid. Here, using a rat animal model of prenatal dexamethasone exposure (PDE) we confirm that PDE can cause susceptibility to convulsions in male offspring and explore the epigenetic programming mechanism underlying this effect related to intrauterine type 2K-Cl cotransporter (KCC2). Wistar rats were injected with dexamethasone (0. Read More

Sci Total Environ 2022 May 14;838(Pt 1):155934. Epub 2022 May 14.

ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Department of Population Studies, Laboratory of Ecotoxicology and Ecology (ECOTOX), Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Research Team of Ecotoxicology, Stress Ecology and Environmental Health (ECOTOX), Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal. Electronic address:

Environmental contamination with lithium (Li) and microplastics (MP) has been steadily increasing and this trend is expected to continue in the future. Many freshwater ecosystems, which are crucial to reach the United Nations Sustainable Development Goals, are particularly vulnerable to Li and MP contamination, and other pressures. The long-term effects of Li, either alone or combined with MP (Li-MP mixtures), were investigated using the freshwater zooplankton micro-crustacean Daphnia magna as model species. Read More

Br J Neurosurg 2022 May 8:1-3. Epub 2022 May 8.

Consultant ENT & Skull Base Surgeon, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Lithium is a psychotropic drug used primarily in the treatment of bipolar disorder. It is renally excreted and characteristically causes nephrogenic diabetes insipidus as an adverse drug reaction. Lithium also requires serum level monitoring as there is a narrow therapeutic window and untreated toxicity can result in neurological sequelae including drowsiness, coma, seizures, and ultimately death. Read More

High Alt Med Biol 2022 Apr 27. Epub 2022 Apr 27.

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Uber, Amy, and Claire Twark. Symptom overlap of acute mountain sickness and lithium toxicity: a case report. 00:000-000, 2022. Read More

Environ Sci Pollut Res Int 2022 Apr 27. Epub 2022 Apr 27.

Departamento de Biologia & CESAM, Universidade de Aveiro, 3810-193, Aveiro, Portugal.

The most important use of lithium (Li) is in rechargeable batteries. The growing use of Li, incorrect disposal of Li-based applications, and inefficient recycling strategies for their elimination will result in the release of this metal into the aquatic systems. Alongside with the impacts caused by pollutants, organisms in coastal ecosystems are also facing environmental changes as those related with climate change scenarios, namely, seawater temperature rise. Read More

Front Oncol 2022 31;12:788770. Epub 2022 Mar 31.

Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, China.

Boron neutron capture therapy (BNCT) is a re-emerging therapy with the ability to selectively kill tumor cells. After the boron delivery agents enter the tumor tissue and enrich the tumor cells, the thermal neutrons trigger the fission of the boron atoms, leading to the release of boron atoms and then leading to the release of the α particles (He) and recoil lithium particles (Li), along with the production of large amounts of energy in the narrow region. With the advantages of targeted therapy and low toxicity, BNCT has become a unique method in the field of radiotherapy. Read More

Curr Drug Saf 2022 Apr 14. Epub 2022 Apr 14.

Lecturer, Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, India.

Background: Bipolar disorder is a chronic psychological disorder and lithium remains the mainstay of therapy. Lithium toxicity can be acute or chronic and the effects may be disabling or life-threatening. The presence of risk factors can increase the chances of lithium toxicity in a patient on long-term lithium therapy. Read More

RSC Adv 2021 Mar 12;11(18):10760-10766. Epub 2021 Mar 12.

Shaanxi Key Laboratory of Optoelectronic Functional Materials and Devices, School of Materials and Chemical Engineering, Xi'an Technological University Xi'an 710021 China +8618602925246 +8618092864735.

Copper oxide (CuO) has emerged as a promising anode material for lithium-ion batteries (LIBs) due to its high theoretical capacity, low cost and low toxicity to the natural environment. However, the low electronic/ionic conductivity and the imponderable volume expansion problem during the charge and discharge process hinder its practical applications. Herein, we introduced three-dimensional clusters of peony-shaped CuO nanosheets (TCP-CuO) to tackle these problems by increasing the surface of the active material. Read More

Molecules 2022 Mar 30;27(7). Epub 2022 Mar 30.

Ivanovo State Medical Academy, 153012 Ivanovo, Russia.

Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic lithium salts. In particular, these salts can be employed as neuroprotective agents since lithium ions demonstrate neuroprotective properties through inhibition of glycogen synthetase kinase-3β and other target proteins, increasing concentrations of endogenous neurotrofic factors. The results of theoretical and experimental studies of organic lithium salts presented here indicate their potential as neuroprotectors. Read More

Biomed Pharmacother 2022 May 25;149:112872. Epub 2022 Mar 25.

Immunology Department, Instituto de Ciencias Básicas y Preclínicas "Victoria de Girón", Universidad de Ciencias Médicas de La Habana, Havana, Cuba. Electronic address:

Introduction: Identifying effective drugs for Coronavirus disease 2019 (COVID-19) is urgently needed. An efficient approach is to evaluate whether existing approved drugs have anti-SARS-CoV-2 effects. The antiviral properties of lithium salts have been studied for many years. Read More

Environ Res 2022 Mar 25;212(Pt A):113112. Epub 2022 Mar 25.

Department of Civil Engineering, School of Environmental Science & Engineering, Donghua University, 201620, 2999, North Renmin Road, Songjiang District, Shanghai, China. Electronic address:

Airborne pathogenic bacteria and fungi transmitted through air-conditioning (AC) systems have been identified as a major public health risk. Air scrubbing is a promising liquid-based air disinfection technique that captures and inactivates airborne pathogens in liquid disinfectants. However, owing to the drawbacks of irritating odor and toxicity, the commonly-used chemical disinfectants cannot be employed for AC systems. Read More

Sci Rep 2022 Mar 22;12(1):4851. Epub 2022 Mar 22.

Institute of Physics, Academia Sinica, 128, Section 2, Academia Road, Taipei, 11529, Taiwan.

Among many transition-metal oxides, FeO anode based lithium ion batteries (LIBs) have been well-investigated because of their high energy and high capacity. Iron is known for elemental abundance and is relatively environmentally friendly as well contains with low toxicity. However, LIBs based on FeO suffer from particle aggregation during charge-discharge processes that affects the cycling performance. Read More

Chemosphere 2022 Jul 19;299:134374. Epub 2022 Mar 19.

Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address:

Methylmercury (MeHg) is a prevalent toxic metal that readily modifies protein thiols. Reactive persulfides that play a role in redox homeostasis are able to inactivate this metal through sulfur adduct formation. Although humans are exposed to other metals that could consume reactive persulfides on a daily basis, the health effects of combined exposure to MeHg and other metals remain unexplored. Read More

Sci Total Environ 2022 Jul 15;830:154577. Epub 2022 Mar 15.

Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China; Guangdong Polytechnic of Environmental Protection Engineering, Foshan 528216, China. Electronic address:

The recovery of metals from spent LiCoO batteries (SLBs) is essential to avoid resource wastage and the production of hazardous waste. However, the major challenge in regard to recovering metals from SLBs using traditional bioleaching is the low Co yield. To overcome this issue, a mixed culture of Acidithiobacillus caldus and Sulfobacillus thermosulfidooxidans was designed for use in SLBs leaching in this study. Read More

Clin Toxicol (Phila) 2022 Mar 15:1-8. Epub 2022 Mar 15.

Monash Clinical Toxicology Unit, Monash Health, Melbourne, Australia.

Introduction: Extracorporeal Treatment (ECTR) is an essential component in management of severe lithium toxicity. The Extracorporeal Treatments in Poisoning (EXTRIP) group's suggested indications for ECTR include "if the expected time to obtain a [Li+] < 1.0mEq/L with optimal management is >36h". Read More

J Korean Med Sci 2022 Mar 14;37(10):e75. Epub 2022 Mar 14.

Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but life-threatening complication. VITT strongly mimics heparin-induced thrombocytopenia (HIT) and shares clinical features. Heparin is commonly used to prevent coagulation during hemodialysis. Read More

Cureus 2022 Jan 19;14(1):e21427. Epub 2022 Jan 19.

Internal Medicine, Tower Health Medical Group, Wyomissing, USA.

Lithium has been widely used as a mood stabilizer. With its narrow therapeutic index, systemic side effects, primarily neurological are a concern. Cardiotoxic effects of lithium are rare, reported as non-specific T-wave flattening, prolonged QT interval, sinus node dysfunction, ventricular tachycardia, cardiomyopathy, and myocardial infarction. Read More

Eur J Clin Invest 2022 May 10;52(5):e13756. Epub 2022 Feb 10.

Explorations Fonctionnelles, Physiologie, APHP.Nord Hôpital Bichat, Paris, France.

Background: Lithium therapy during bipolar disorder is associated with an increased risk of chronic kidney disease (CKD) that is slowly progressive and undetectable at early stages. We aimed at identifying kidney image texture features as possible imaging biomarkers of decreased measured glomerular filtration rate (mGFR) using radiomics of T2-weighted magnetic resonance imaging (MRI).

Methods: One hundred and eight patients treated with lithium were evaluated including mGFR and kidney MRI, with T2-weighted sequence single-shot fast spin-echo. Read More

Curr Psychiatry Rep 2022 01 25;24(1):89-98. Epub 2022 Jan 25.

Sanford Center for Biobehavioral Research, ND, 58103, Fargo, USA.

Purpose Of Review: We review evidence for assessing and monitoring psychotropic medications in metabolic and bariatric surgery (MBS) patients. We describe weight gain side effects, potential perioperative risks, pharmacokinetic changes that occur after MBS, and conclude with clinical recommendations.

Recent Findings: Research on psychiatric medication use and post-MBS weight outcomes is lacking and inconsistent; however, there is consistent evidence that, though variable, psychiatric medication use is associated with weight gain. Read More

Biomed Mater 2022 02 7;17(2). Epub 2022 Feb 7.

Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, People's Republic of China.

Lithium disilicate (LiSiO) glass-ceramic is a commonly used dental ceramic material. In this study, LiSiOwhiskers were prepared by the hydrothermal method, mixed with LiSiOglass powders, and LiSiOwhisker-reinforced glass-ceramics were prepared by reaction sintering. The biosafety of the new LiSiOglass-ceramics were evaluated bycytotoxicity, hemolysis, oral mucosal irritation, acute systemic toxicity, and subacute systemic toxicity (oral route) tests according to ISO 7405/ISO 10993 standards. Read More

Evid Based Complement Alternat Med 2022 13;2022:8548378. Epub 2022 Jan 13.

College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Qishiwei Zhenzhu pills (QSW) was first recorded in the Tibetan medicine classic and has been used to treat "Baimai" disease, stroke, paralysis, hemiplegia, cerebral hemorrhage, and other diseases till today. This prescription contains more than 70 medicines including myrobalan, pearl, agate, opal, bezoar, coral, musk, gold, silver, and a mineral mixture Zuotai. As a result, QSW contains a large amount of mercury, copper, lead, and other trace elements. Read More

Cells 2022 01 14;11(2). Epub 2022 Jan 14.

Division of Science, Yale-NUS College, Singapore 138527, Singapore.

Patients with Alzheimer's disease suffer from a decrease in brain mass and a prevalence of amyloid-β plaques. These plaques are thought to play a role in disease progression, but their exact role is not entirely established. We developed an optogenetic model to induce amyloid-β intracellular oligomerization to model distinct disease etiologies. Read More

Toxicology 2022 02 10;467:153098. Epub 2022 Jan 10.

Division for Risk Assessment and Nutrition, Group for Chemical Risk Assessment and GMO, National Food Institute, Technical University of Denmark, Kemitorvet, 201, 031, 2800 Kgs. Lyngby, Denmark. Electronic address:

Molybdenum, lithium, and tungsten are constituents of many products, and exposure to these elements potentially occurs at work. Therefore it is important to determine at what levels they are toxic, and thus we set out to review their pulmonary toxicity, genotoxicity, and carcinogenicity. After pulmonary exposure, molybdenum and tungsten are increased in multiple tissues; data on the distribution of lithium are limited. Read More

Sci Total Environ 2022 Mar 3;814:152870. Epub 2022 Jan 3.

School of Materials Science and Engineering, Northeastern University, Shenyang 110819, PR China.

The automotive industry is currently on the verge of electrical transition, and the environmental performance of electric vehicles (EVs) is of great concern. To assess the environmental performance of EVs scientifically and accurately, we reviewed the life cycle environmental impacts of EVs and compared them with those of internal combustion engine vehicles (ICEVs). Considering that the battery is the core component of EVs, we further summarise the environmental impacts of battery production, use, secondary utilisation, recycling, and remanufacturing. Read More

Environ Toxicol 2022 Apr 5;37(4):825-835. Epub 2022 Jan 5.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Humans and animals may be exposed to increasing contaminant lithium (Li) concentrations in the environment with the use and disposal of Li-containing products. Meanwhile, Li plays a key role in the treatment of human mental disorders, while the excessive accumulation of Li salts in the body can cause renal damage and nephrotic syndrome. In this study, the mechanism of renal inflammatory reaction induced by Li excessive intake was studied by establishing mice models in vitro and in vivo. Read More

Biol Pharm Bull 2022 ;45(1):86-93

Department of Neurology, Huashan Hospital, Fudan University.

Status epilepticus (SE) induced inflammation plays an important role in the pathogenesis of SE. Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA Snhg5) has been reported in various inflammatory diseases. However, the mechanism of Snhg5 regulated inflammation in SE remains unclear. Read More

Cancers (Basel) 2021 Dec 9;13(24). Epub 2021 Dec 9.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

The purpose of this work was to investigate whether minibeam therapy with heavy ions might offer improvements of the therapeutic ratio for the treatment of human brain cancers. To assess neurotoxicity, we irradiated normal juvenile rats using 120 MeV lithium-7 ions at an absorbed integral dose of 20 Gy. Beams were configured either as a solid parallel circular beam or as an array of planar parallel minibeams having 300-micron width and 1-mm center-to-center spacing within a circular array. Read More

Environ Sci Pollut Res Int 2022 Apr 27;29(17):24983-24994. Epub 2021 Nov 27.

NAFOMAT Group, Departamentos de Física Aplicada y Física de Partículas, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

The applicability of ionic liquids (ILs) has increased over the last years, and even new opportunities are becoming a reality, i.e. mixtures of pure IL and inorganic salt as electrolytes for smart electrochemical devices, yet the effects on the environment are almost unknown. Read More

Pharmaceutics 2021 Nov 1;13(11). Epub 2021 Nov 1.

Department of Nursing, School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Despite established efficacy in bipolar disorder patients, lithium (Li) therapy has serious side effects, particularly chronic kidney disease. We examined the safety and behavioral effects of combined chronic low-dose aspirin plus low-dose Li in rats to explore the toxicity and therapeutic potential of this treatment. Rats were fed regular or Li-containing food (0. Read More