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Antioxidants (Basel) 2019 Apr 16;8(4). Epub 2019 Apr 16.

Clínica CIROM, Centro de Implantología and Rehabilitación Oral Multidisciplinaria, 30001 Murcia, Spain.

The toxicity of heavy metals such as Hg is a serious risk for human health. We evaluated whether 90 days of nutritional supplementation (d90, = 16) with (CV) and extracts in conjunction with aminosulphurate (nutraceuticals) supplementation could detox heavy metal levels in patients with long-term titanium dental implants (average: three, average: 12 years in mouth) and/or amalgam fillings (average: four, average: 15 years) compared to baseline levels (d0: before any supplementation, = 16) and untreated controls (without dental materials) of similar age (control, = 21). In this study, we compared levels of several heavy metals/oligoelements in these patients after 90 days ( = 16) of nutritional supplementation with CV and aminozuphrates extract with their own baseline levels (d0, = 16) and untreated controls ( = 21); 16 patients averaging 44 age years old with long-term dental amalgams and titanium implants for at least 10 years (average: 12 years) were recruited, as well as 21 non-supplemented controls (without dental materials) of similar age. Read More

J Clean Prod 2019 Apr;215:634-649

European Commission, Joint Research Centre, Directorate for Energy, Transport and Climate, Energy Storage Unit, Westerduinweg 3, NL-1755 LE, Petten, the Netherlands.

Traction batteries are a key factor in the environmental sustainability of electric mobility and, therefore, it is necessary to evaluate their environmental performance to allow a comprehensive sustainability assessment of electric mobility. This article presents an environmental assessment of a lithium-ion traction battery for plug-in hybrid electric vehicles, characterized by a composite cathode material of lithium manganese oxide (LiMnO) and lithium nickel manganese cobalt oxide Li(NiCoMn)O. Composite cathode material is an emerging technology that promises to combine the merits of several active materials into a hybrid electrode to optimize performance and reduce costs. Read More

Ultrastruct Pathol 2019 Apr 13:1-14. Epub 2019 Apr 13.

a Department of Histology and Cell Biology, Benha Faculty of Medicine , Benha University , Benha , Egypt.

Lithium (Li) is used for the treatment and prophylaxis of mental disorders, associated with many serious hazards. Resveratrol (RSV) has various beneficial therapeutic effects. Platelet-rich plasma (PRP) is a new promising curative tool. Read More

Environ Geochem Health 2019 Apr 13. Epub 2019 Apr 13.

Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235 - s/n - Setor Universitário, Goiânia, Goiás, Brazil.

Environmental degradation has increased, mainly as a result of anthropogenic effects arising from population, industrial and agricultural growth. Water pollution is a problem that affects health, safety and welfare of the whole biota which shares the same environment. In Goiânia and metropolitan region, the main water body is the Meia Ponte River that is used for the abstraction of water, disposal of treated wastewater and effluents. Read More

J Toxicol Environ Health B Crit Rev 2019 Apr 12:1-12. Epub 2019 Apr 12.

a Division of Toxicology, College of Pharmacy , Sungkyunkwan University , Suwon , Gyeonggi-do , South Korea.

Use of lithium-ion batteries has raised safety issues owing to chemical leakages, overcharging, external heating, or explosions. A risk assessment was conducted for hydrofluoric acid (HF) and lithium hydroxide (LiOH) which potential might leak from lithium-ion batteries. The inhalation no-observed-adverse-effect-level (NOAEL) for HF was 0. Read More

Dent Mater 2019 Apr 8. Epub 2019 Apr 8.

Centre for Craniofacial and Regenerative Biology, King's College London, London SE1 9RT, UK. Electronic address:

Objectives: Wnt/β-catenin signalling plays important roles in regeneration, particularly in hard tissues such as bone and teeth, and can be regulated by small molecule antagonists of glycogen synthase kinase 3 (GSK3); however, small molecules can be difficult to deliver clinically. Lithium (Li) is also a GSK3 antagonist and can be incorporated into bioactive glasses (BG), which can be used clinically in dental and bone repair applications and tuned to quickly release their constituent ions.

Methods: Here, we created phosphate (P)- and borate (B)-based BG that also contained Li (LiPBG and LiBBG) and examined their ion release kinetics and the toxicity of their dissolution ions on mouse 17IA4 dental pulp cells. Read More

Ir J Psychol Med 2019 Apr 10:1-8. Epub 2019 Apr 10.

Department of Psychiatry, Trinity Centre for Health Sciences,Tallaght University Hospital,Dublin 24,Ireland.

Objectives: Lithium-treated patients with polyuria are at increased risk of lithium toxicity. We aimed to describe the clinical benefits and risks of different management strategies for polyuria in community lithium-treated patients.

Methods: This is a naturalistic, observational, prospective 12-month cohort study of lithium-treated patients with polyuria attending a community mental health service in Dublin, Ireland. Read More

Nervenarzt 2019 Apr 2. Epub 2019 Apr 2.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

Despite unlimited access to therapeutic drug monitoring lithium poisoning is still a common and potentially life-threatening but in most cases preventable complication of lithium treatment; however, it is still considered to be the gold standard in the treatment of affective disorders. The necessity of drug monitoring and potential lithium toxicity substantiate the skepticism of many therapists with respect to this often very effective treatment. This therefore limits the use of lithium although the unique therapeutic effects and high efficiency are well known. Read More

J Clin Psychopharmacol 2019 May/Jun;39(3):273-275

Department of Psychiatry, State University of New York at Stony Brook, Stony Brook, NY

Environ Sci Technol 2019 Apr 21;53(7):3860-3870. Epub 2019 Mar 21.

School of Freshwater Sciences , University of Wisconsin-Milwaukee , 600 East Greenfield Avenue , Milwaukee , Wisconsin 53204 , United States.

Most studies of nanomaterial environmental impacts have focused on relatively simple first-generation nanomaterials, including metals or metal oxides (e.g., Ag, ZnO) for which dissolution largely accounts for toxicity. Read More

Analyst 2019 Apr;144(8):2480-2497

Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Recently, water contamination caused by metal ions has become one of the most serious problems as it has caused several deaths and socioeconomic problems around the world. Hence, the fast and accurate detection of metal ions in aqueous media has become the most important area of research; from time to time, new probes have been designed for this purpose. Among the previously reported sensors, probes based on fluorescent organic nanoparticles (FONs) have been gaining tremendous attention due to their ease of preparation/fabrication, synthetic diversity according to targeted metal ions, quick response, high selectivity toward different analytes at lower concentrations, tenable optical properties, and less toxicity. Read More

ChemSusChem 2019 Mar 7. Epub 2019 Mar 7.

Forschungszentrum Julich GmbH, Helmholtz-Institut Münster, Correnstr. 46, 48145, Münster, GERMANY.

Silicon (Si) has materialized as the Next-Generation anode material for high capacity lithium-ion batteries (LIBs). It is currently of scientific and practical interest to encounter the increasingly growing demands for high-energy/power density electrochemical energy storage devices for use in electric vehicles (xEVs), renewable energy sources, and smart grid/utility applications, improvements to the existing conventional lithium-ion batteries (LIBs) are required to provide higher energy longer cycle lives etc. This is attributed to its unparalleled theoretical capacity (4200 mAh g-1 for Li4. Read More

Environ Res 2018 Dec 21;172:249-257. Epub 2018 Dec 21.

Department of Environmental Health, Emory University, Atlanta, GA, USA; Department of Epidemiology, Emory University, Atlanta, GA, USA. Electronic address:

Goal: The goal of this study was to evaluate the association between groundwater arsenic and fasting blood glucose in the context of other groundwater chemicals, in Bangladesh.

Methods: Fasting blood glucose, gender, body mass index, sociodemographic variables, and diabetes medication use were measured among adults ≥ 35 years of age (n = 6587) participating in the Bangladesh Demographic and Health Survey (BDHS) 2011. Groundwater chemicals in 3534 well water samples were measured in the British Geological Survey (BGS) and Department of Public Health Engineering (DPHE) 1998-99 survey. Read More

Waste Manag 2019 Feb 16;85:437-444. Epub 2019 Jan 16.

Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China; Collaborative Innovation Center of Electric Vehicles in Beijing, Beijing 100081, China. Electronic address:

Nowadays LiFePO cathode develops rapidly for its advantages of long life span, low cost and non-toxicity, especially in electrical vehicle markets. Because of its stable olivine structure, LiFePO is difficult to be recycled by the conventional hydrometallurgical processes as for LiCoO or LiNiCoMnO. Pyrometallurgical processes consume much energy and release toxic gases. Read More

Nano Lett 2019 03 21;19(3):1990-1997. Epub 2019 Feb 21.

Environmental Molecular Sciences Laboratory , Pacific Northwest National Laboratory , Richland , Washington 99354 , United States.

Engineered nanoparticles (NPs) can negatively impact biological systems through induced generation of reactive oxygen species (ROS). Overproduced ROS cause biochemical damage and hence need to be effectively buffered by a sophisticated cellular oxidative stress response system. How this complex cellular system, which consists of multiple enzymes, responds to NP-induced ROS is largely unknown. Read More

J Chromatogr A 2019 May 11;1592:188-191. Epub 2019 Feb 11.

University of Münster, MEET Battery Research Center, Corrensstraße 46, 48149, Münster, Germany. Electronic address:

Nowadays, lithium ion batteries (LIBs) are the preferred energy supply for consumer electronics and electric vehicles. But, intrinsic reactions in the LIB system lead to a reduced battery life and impaired safety properties. Organo(fluoro)phosphates (O(F)Ps) as decomposition product of the conducting salt and the organic carbonate solvent molecules of the LIB electrolyte are of high interest due to structural similarities to chemical warfare agents and therefore a supposedly high toxicity. Read More

Eur J Case Rep Intern Med 2018 26;5(6):000843. Epub 2018 Jun 26.

Internal Medicine 'T', Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, affiliated to the Sackler School of Medicine, Tel-Aviv, Israel.

Introduction: The combination of acute/sub-acute neurological and metabolic derangements should always raise the suspicion of toxicity, either endogenous or exogenous. The adverse effects of psychiatric medications are especially difficult to determine since the psychiatric background of patients is often inaccessible.

Clinical Presentation: A 66-year-old man presented to the emergency department with dysarthria and uncontrolled tremor, rapidly deteriorating into a complex of severe neurological and metabolic derangements. Read More

Appl Spectrosc 2019 Apr 21;73(4):387-394. Epub 2019 Mar 21.

1 Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Mapping of element distributions and diffusion processes in plant tissue has great significance for understanding the systematic uptake, transport, and accumulation of nutrients and harmful elements in plants, and for studying the interaction between plants and the environment. In this work, we used laser-induced breakdown spectroscopy (LIBS) to study the elemental accumulation of Li and its diffusion in plant leaves. The spatially resolved information that LIBS offers, combined with its high sensitivity to light elements make this technology highly advantageous for the analysis of Li. Read More

Front Chem 2018 8;6:652. Epub 2019 Jan 8.

Beijing Key Laboratory of Construction-Tailorable Advanced Functional Materials and Green Applications, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, China.

Colloidal nanocrystals (NCs) have emerged as promising materials in optoelectronic devices and biological imaging application due to their tailorable properties through size, shape, and composition. Among these NCs, metal phosphide is an important class, in parallel with metal chalcogenide. In this review, we summarize the recent progress regarding the chemical synthesis and applications of colloidal metal phosphide NCs. Read More

Nephrol Ther 2019 Apr 15;15(2):120-126. Epub 2019 Jan 15.

Service de néphrologie adulte, hôpital Necker, université Paris Descartes, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

Besides its efficiency, lithium has a narrow therapeutic index and can result in considerable toxicity. Among the potential side effects, two types of renal toxicity are observed: a decreased renal concentrating ability and a chronic renal failure. Lithium-induced polyuria is frequent, estimated to affect up to 40% of patients, and develops usually early. Read More

Environ Res 2019 Apr 7;171:60-68. Epub 2019 Jan 7.

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Electronic address:

Background: Experimental studies show developmental toxicity of boron and we recently found impaired weight and length in newborns of mothers exposed to boron through drinking water during pregnancy.

Objectives: To evaluate potential impact of pre- and postnatal boron exposure on infant anthropometry.

Methods: In our mother-child cohort (n = 177) in Argentinean Andes, where drinking water concentrations of boron, lithium and arsenic have been found to vary considerably, we collected maternal blood and urine during and after pregnancy, placenta, breast milk, as well as infant urine and blood during the first 6 months of life. Read More

Ir J Med Sci 2019 Jan 10. Epub 2019 Jan 10.

Department of Psychiatry, University Hospital Galway, Galway, Ireland.

Introduction: Lithium is a medication indicated for the treatment of bipolar disorder and treatment-resistant depression, with a narrow therapeutic index. Overdose, either acute or chronic can result in neurological symptoms, requiring dialysis and admission to intensive care in some cases. Lithium toxicity is avoidable with careful monitoring. Read More

Turk Neurosurg 2019 ;29(1):95-105

Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey.

Aim: To investigate possible correlations between serum S100B levels and microglial/astrocytic activation in status epilepticus (SE) in lithium-pilocarpine-exposed rat hippocampi and whether serum S100B levels linearly reflect neuroinflammation. Additionally, to assess the effects of minocycline (M), an inhibitor of neuroinflammation.

Material And Methods: Rats were divided into 4 groups (6/group), namely, control (C), sham, SE, and SE+M. Read More

ACS Appl Energy Mater 2018 Dec 19;1(12):7046-7051. Epub 2018 Nov 19.

MESA+ Institute for Nanotechnology, University of Twente, 7500 AE, Enschede, Netherlands.

A promising cathode material for rechargeable batteries is LiMnO, which exhibits higher operating voltage, reduced toxicity and lower costs as compared to commonly used LiCoO cathodes. However, LiMnO suffers from limited cycle life, as excessive capacity fading occurs during battery cycling due to dissolution of Mn into the acidic electrolyte. Here, we show that by structural engineering of stable, epitaxial LiMnO thin films the electrochemical properties can be enhanced as compared to polycrystalline samples. Read More

J Pharm Bioallied Sci 2018 Oct-Dec;10(4):240-245

Tomsk Polytechnic University, Research School Chemical and Biomedical Technologies, Department of Chemical Engineering, Tomsk, Russia.

Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer. These lithium-based substances have a lot of potential properties because of the anionic component of the Krebs cycle substrates, which take part in basic intracellular biochemical process. Read More

Nat Commun 2018 12 14;9(1):5320. Epub 2018 Dec 14.

Helmholtz Institute Münster - Forschungszentrum Jülich GmbH (IEK 12), Corrensstrasse 46, 48149 Münster, D-48149, Münster, Germany.

The continuously increasing number and size of lithium-based batteries developed for large-scale applications raise serious environmental concerns. Herein, we address the issues related to electrolyte toxicity and safety by proposing a "water-in-ionomer" type of electrolyte which replaces organic solvents by water and expensive and toxic fluorinated lithium salts by a non-fluorinated, inexpensive and non-toxic superabsorbing ionomer, lithium polyacrylate. Interestingly, the electrochemical stability window of this electrolyte is extended greatly, even for high water contents. Read More

Front Mol Neurosci 2018 22;11:425. Epub 2018 Nov 22.

Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lithium is a widely used and effective treatment for individuals with psycho-neurological disorders, and it exhibits protective and regenerative properties in multiple brain injury animal models, but the clinical experience in young children is limited due to potential toxicity. As an interim analysis, this paper reports the safety/tolerability profiles of low-dose lithium treatment in children with intellectual disability (ID) and its possible beneficial effects. In a randomized, single-center clinical trial, 124 children with ID were given either oral lithium carbonate 6 mg/kg twice per day or the same dose of calcium carbonate as a placebo ( = 62/group) for 3 months. Read More

Obes Surg 2019 Feb;29(2):735-738

Bariatric Surgery Unit, General Surgery Division, The Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Lithium is one of the major treatment options in bipolar disorder. Bariatric surgery can significantly modify the oral bioavailability of drugs, and lithium is no exception; although in most cases drug absorption seems to decrease, in the case of lithium, toxicity is the risk. In this article, we describe a 61-year-old male patient presented with lithium toxicity, including newly diagnosed severe bradycardia requiring a permanent pacemaker, after undergoing sleeve gastrectomy. Read More

Bipolar Disord 2019 Mar 16;21(2):117-123. Epub 2018 Nov 16.

Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio.

Objectives: Despite the growing numbers and proportion of older adults with bipolar disorder (OABD), there are very limited guidelines for the use of lithium with its double-edged potential for effectiveness and toxicity in this population. The primary aims of this Delphi survey were: (a) To determine the place of lithium among the preferred choices for maintenance treatment of OABD. (b) To provide detailed clinical guidelines for the safe and effective use of lithium in OABD. Read More

Sci Total Environ 2019 Feb 18;652:202-211. Epub 2018 Oct 18.

Department of Agronomy, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

The nano forms of the metals molybdenum oxide (MoO), nickel oxide (NiO) and lithium oxide (LiO) are finding wide application in advanced technologies including batteries and fuel cells. We evaluated soil responses to nanoMoO, nanoNiO, and nanoLiO as some environmental release of the materials, either directly or following the land application of biosolids, is expected. Using Drummer soil (Fine-silty, mixed, superactive, mesic Typic Endoaquolls), we evaluated the impacts of the three nanometals on soil gas (NO, CH, and CO) emissions, enzyme activities (β-glucosidase and urease), and microbial community structure (bacterial, archaeal, and eukaryal) in a 60 day microcosms incubation. Read More

Epilepsy Behav 2018 11 15;88:283-294. Epub 2018 Oct 15.

Instituto Nacional de Pediatría, Subdirección de Medicina experimental, Laboratorio de Neurociencias, México. Electronic address:

Synaptic vesicle protein 2A (SV2A) has become an attractive target of investigation because of its role in the pathophysiology of epilepsy; SV2A is expressed ubiquitously throughout the brain in all nerve terminals independently of their neurotransmitter content and plays an important but poorly defined role in neurotransmission. Previous studies have shown that modifications in the SV2A protein expression could be a direct consequence of disease severity. Furthermore, these SV2A modifications may depend on specific changes in the nerve tissue following the induction of epilepsy and might be present in both excitatory and inhibitory terminals. Read More

Pharmacol Rep 2018 Dec 17;70(6):1168-1172. Epub 2018 May 17.

Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.

Background: Selenium is an essential element which shows protective properties against diverse harmful factors. Lithium compounds are widely used in medicine, but, in spite of undoubted beneficial effects, treatment with these compounds may lead to severe side effects, including renal, gastrointestinal, neurological, endocrine and metabolic disorders. This study was aimed at evaluating the influence of selenium and/or lithium on lithium, iron, zinc and copper content in rats' erythrocytes as well as estimate the action of additional selenium on lithium exposure effects. Read More

Front Chem 2018 24;6:428. Epub 2018 Sep 24.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, China.

CuO is a promising anode material for lithium-ion batteries due to its high theoretical capacity, low cost, and non-toxicity. However, its practical application has been plagued by low conductivity and poor cyclability. Herein, we report the facile synthesis of porous defective CuO nanosheets by a simple wet-chemical route paired with controlled annealing. Read More

Food Chem Toxicol 2018 Nov 25;121:583-592. Epub 2018 Sep 25.

Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S.FDA, USA.

Due to the high cost and long duration of traditional testing methods for developmental neurotoxicity (DNT), only a small fraction of chemicals that humans are exposed to have been assessed for DNT activity. In order to ensure public safety, human-predictive methods for DNT detection that are faster and less resource intensive are urgently required. Using Caenorhabditis elegans, a novel worm Development and Activity test (wDAT) has been designed that uses a relatively inexpensive small-animal activity tracker and takes less than 4 days to complete. Read More

Clin Toxicol (Phila) 2019 Jan 27;57(1):1-9. Epub 2018 Sep 27.

a Department of Intensive Care , Cliniques St-Luc, Université catholique de Louvain , Brussels , Belgium.

Background: Dilated cardiomyopathy is a frequent disease responsible for 40-50% of cases of heart failure. Idiopathic cardiomyopathy is a primary disorder often related to familial/genetic predisposition. Before the diagnosis of idiopathic cardiomyopathy is made, clinicians must not only rule out viral and immune causes, but also toxic causes such as drugs, environmental agents, illicit substances and natural toxins. Read More

iScience 2018 Aug 26;6:151-198. Epub 2018 Jul 26.

Key Laboratory of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130022, China. Electronic address:

Lithium-sulfur batteries (LSBs) represent a promising energy storage technology, and they show potential for next-generation high-energy systems due to their high specific capacity, abundant constitutive resources, non-toxicity, low cost, and environment friendliness. Unlike their ubiquitous lithium-ion battery counterparts, the application of LSBs is challenged by several obstacles, including short cycling life, limited sulfur loading, and severe shuttling effect of polysulfides. To make LSBs a viable technology, it is very important to design and synthesize outstanding cathode materials with novel structures and properties. Read More

Front Mol Neurosci 2018 28;11:297. Epub 2018 Aug 28.

Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.

Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving neurological function is therefore well-described, stimulating the investigation of its potential use in several neurodegenerative conditions including Alzheimer's (AD), Parkinson's (PD) and Huntington's (HD) diseases. A narrow therapeutic window for these effects, however, has led to concerted efforts to understand the molecular mechanisms of lithium action in the brain, in order to develop more selective treatments that harness its neuroprotective potential whilst limiting contraindications. Read More

Exp Neurol 2018 12 8;310:70-83. Epub 2018 Sep 8.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Cell transplantation based therapy is a promising strategy for treating intractable epilepsies. Inhibition of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) is a powerful experimental approach for remote control of different partial seizure types, when targeting the seizure focus is not amenable. Here, we tested the hypothesis that grafting of embryonic/fetal neural precursor cells (NPCs) from various species (rat, human, pig) into STN or SNr of adult rats induces anticonvulsant effects. Read More

Sci Total Environ 2018 Dec 4;643:1579-1589. Epub 2018 Jul 4.

Sustainable Industrial Systems, School of Chemical Engineering and Analytical Science, The University of Manchester, Manchester M13 9PL, UK.

One of the benefits of hybrid solar PV-battery systems is that they can reduce grid dependency and help balance electricity supply and demand. However, their environmental impacts and benefits remain underexplored. This study considers for the first time life cycle environmental impacts of domestic-scale PV-battery systems in Turkey, integrating multi-crystalline PV and lithium-ion battery. Read More

Transl Psychiatry 2018 08 22;8(1):163. Epub 2018 Aug 22.

Institut de Médecine Régénératrice et de Biothérapie (I.M.R.B.), Physiopathologie, diagnostic et thérapie cellulaire des affections neurodégénératives-Institut National de la Santé et de la Recherche Médicale Université de Montpellier U1183 Centre Hospitalo, Universitaire de Montpellier, Montpellier, France.

Prion diseases still remain incurable despite multiple efforts to develop a treatment. Therefore, it is important to find strategies to at least reduce the symptoms. Lithium has been considered as a neuroprotective agent for years, and the objective of this preclinical study was to evaluate the efficacy of lithium delivered as a water-in-oil microemulsion (Aonys). Read More

J Inorg Biochem 2018 11 16;188:88-95. Epub 2018 Aug 16.

Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS, Portugal.

Five silver camphor complexes of formulae [Ag(L)(L')] (1,3,5) or [Ag(L)(L')] (2,4) were synthesized from silver nitrate and the suitable camphor carboxylate (L) or camphor carboxamides (L, L). The complexes were characterized by elemental analysis and spectroscopic techniques (NMR, FTIR, XPS). Computational calculations support coordination of the carboxylate group to silver, in the case of complex 2 and combined mixed keto/carboxylate in the case of complex 1. Read More

Chem Soc Rev 2018 Oct;47(19):7239-7302

Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.

Ever-growing global energy needs and environmental damage have motivated the pursuit of sustainable energy sources and storage technologies. As attractive energy storage technologies to integrate renewable resources and electric transportation, rechargeable batteries, including lead-acid, nickel-metal hydride, nickel-cadmium, and lithium-ion batteries, are undergoing unprecedented rapid development. However, the intrinsic toxicity of rechargeable batteries arising from their use of toxic materials is potentially environmentally hazardous. Read More

Neurotherapeutics 2018 10;15(4):1093-1111

Institute of Neurosciences, Department of Neurobiology and Collaborative Innovation Center for Brain Science, The Fourth Military Medical University, No. 169, Changle West Road, Xi'an, 710032, China.

Inflammation is implicated in epileptogenesis. Activated microglia and macrophages (MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal models of epilepsy. It is not yet known how the MG/MΦ activation phenotype affects pathological changes in the brain after a single seizure. Read More

Dent J (Basel) 2018 Aug 2;6(3). Epub 2018 Aug 2.

Faculty of Dentistry, Federal University of Rio de Janeiro, 255th Professor Rodolpho Paulo Rocco Street-Ilha do Fundão, Rio de Janeiro-RJ21941-913, Brazil.

Irreversible hydrocolloids (IR) is a dental impression material commonly used in Brazilian and European dental practice because it is inexpensive, easy to handle, has good reproductive detail and is comfortable for the patient. This research aimed to analyze the chemical composition of eight different IRs for dental use. A sample of 0. Read More

Ecotoxicol Environ Saf 2018 Oct 14;162:505-513. Epub 2018 Jul 14.

University of Siena, Dept. of Life Sciences, University of Siena, Via Mattioli 4, I-53100 Siena, Italy.

Restoration potential of mine wastes or approaches to improve soil conditions and to ameliorate phytotoxicity on these sites may be simulated in standardized greenhouse experiments. Plants can be cultivated side by side on materials from different origins in dilution series with defined admixtures of certain aggregates. Mine wastes used in the present study originated from Fenice Capanne (FC, Tuscany, Italy) and Altenberg (ALT, Saxony, Germany). Read More