1,639 results match your criteria Toxicity Lidocaine


Toxicological analysis of cocaine adulterants in blood samples.

Forensic Sci Int 2019 Mar 12;299:95-102. Epub 2019 Mar 12.

National Institute of Legal Medicine and Forensic Sciences, Portugal.

Cocaine was the second most widely used drug in Europe in 2016, with 3.5 million consumers aged 15-64 years old. Adulterants are pharmacologically active substances developed for medical purposes, however, there is little knowledge about their influence in the human body when there is concomitant use with cocaine. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.03.005DOI Listing
March 2019
1 Read

Perioperative IV Lidocaine Infusion Adverse Reaction: A Case Report.

A A Pract 2019 Mar 25. Epub 2019 Mar 25.

MedStar Georgetown University Hospital, Washington, DC.

IV lidocaine is increasingly being utilized as an opioid-sparing analgesic. A 55-year-old man with well-controlled human immunodeficiency virus on highly active antiretroviral therapy was prescribed a lidocaine infusion at 1 mg/kg/h for postoperative pain. On postoperative day 2, the patient experienced 4 unresponsive episodes with tachycardia, hypertension, and oxygen desaturation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001002DOI Listing
March 2019
9 Reads

Cytotoxicity of drugs injected into joints in orthopaedics.

Bone Joint Res 2019 Feb 2;8(2):41-48. Epub 2019 Mar 2.

University Center for Orthopaedics and Traumatology, and Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus at Technische Universität Dresden, Dresden, Germany.

Objectives: Intra-articular injections of local anaesthetics (LA), glucocorticoids (GC), or hyaluronic acid (HA) are used to treat osteoarthritis (OA). Contrast agents (CA) are needed to prove successful intra-articular injection or aspiration, or to visualize articular structures dynamically during fluoroscopy. Tranexamic acid (TA) is used to control haemostasis and prevent excessive intra-articular bleeding. Read More

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http://dx.doi.org/10.1302/2046-3758.82.BJR-2018-0099.R1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397327PMC
February 2019
1 Read

Brainstem Anaesthesia after Retrobulbar Block.

Open Med (Wars) 2019 2;14:287-291. Epub 2019 Mar 2.

Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Regional anaesthesia techniques in ophthalmology are usually utilized for day case surgery. During various procedures, profound akinesia of the eye and anaesthesia of the surgical site are required, both of which are achieved with retrobulbar block. Due to the anatomy of the eye, life-threatening complications are possible. Read More

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http://dx.doi.org/10.1515/med-2019-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419387PMC
March 2019
1 Read

Lidocaine safety after saphenous vein tumescent anesthesia.

Phlebology 2019 Mar 14:268355519836834. Epub 2019 Mar 14.

3 Department of Otolaryngology - Head & Neck Surgery, University of Cincinnati, Cincinnati, USA.

Objectives: For endovenous thermal ablation of the saphenous veins, tumescent lidocaine anesthesia is often used. Unfortunately, information is sparse on the pharmacokinetics of lidocaine absorption and its maximum safe dose. The aim of this study was to evaluate plasma concentration of lidocaine on 12 lead electrocardiograms (ECGs) and symptoms over time after the administration of tumescent lidocaine during endovenous thermal ablation procedures in healthy volunteers. Read More

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http://dx.doi.org/10.1177/0268355519836834DOI Listing
March 2019
1 Read

Intravenous lidocaine infusion as a component of multimodal analgesia for colorectal surgery-measurement of plasma levels.

Perioper Med (Lond) 2019 26;8. Epub 2019 Feb 26.

1Western General Hospital, Edinburgh, UK.

Background: Growing evidence suggests that intravenous lidocaine as a component of multimodal analgesia improves recovery after major colorectal surgery. There is little published data regarding ideal dosing and target plasma concentration in this context, and we wanted to establish our dosing schedule was safe by measuring blood levels of lidocaine.

Methods: We measured the plasma lidocaine concentration of 32 patients at 30 min, 6 h and 12 h after starting intravenous lidocaine infusion for analgesia after major colorectal surgery. Read More

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http://dx.doi.org/10.1186/s13741-019-0112-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390549PMC
February 2019

Safety and Tolerability of Lidocaine Infusions as a Component of Multimodal Postoperative Analgesia in Children.

J Pediatr Pharmacol Ther 2019 Jan-Feb;24(1):34-38

Objectives: Use of lidocaine as part of a multimodal approach to postoperative pain management has increased in adults; however, limited information is available regarding safety and tolerability in pediatrics. This study's primary objective was to evaluate the incidence of adverse effects related to lidocaine infusions in a sample of pediatric patients.

Methods: A retrospective analysis was conducted in pediatric patients receiving lidocaine infusion for the management of postoperative analgesia at the University of Virginia Health System. Read More

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http://dx.doi.org/10.5863/1551-6776-24.1.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397014PMC
March 2019
3 Reads

Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling.

Ecotoxicol Environ Saf 2019 May 31;172:232-239. Epub 2019 Jan 31.

Universidad San Jorge, Campus Universitario, Autov A23 km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The final fate of many drugs is release into the natural aquatic environment. It is necessary to assess the toxicity caused by this situation and the associated concerns for human beings. Zebrafish (Danio rerio) is a common biomodel used to assess toxicity in aquatic environments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.081DOI Listing
May 2019
2 Reads

Prolonged Pulseless Electrical Activity Cardiac Arrest After Intranasal Injection of Lidocaine With Epinephrine: A Case Report.

A A Pract 2019 Jan 16. Epub 2019 Jan 16.

Department of Anesthesiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois.

Local anesthetic toxicity is a rare but serious complication of local anesthetic administration. Although lidocaine has a safety profile superior to other amide local anesthetics, we report a case of cardiac arrest after intranasal injection of lidocaine. The case involves a 22-year-old healthy woman who experienced pulseless electrical activity shortly after a submucosal injection of 2. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000962DOI Listing
January 2019
4 Reads

Preclinical safety assessment of antipyrine combined with lidocaine hydrochloride as ear drops.

Regul Toxicol Pharmacol 2019 Apr 8;103:34-40. Epub 2019 Jan 8.

Naval Medical Research Institute, Second Military Medical University, 880 Xiangyin Road, Shanghai, 200433, China. Electronic address:

This study was designed to assess the preclinical toxicity of antipyrine combined with lidocaine hydrochloride ear drops (ALED) and support the clinical trials of ALED in clinical settings in China. All the experiments including acute toxicity in rodents, skin sensitization toxicity in guinea pigs, skin irritation toxicity in rabbits and chronic toxicity in rats were performed according to China Food and Drug Administration guidelines. The maximum tolerated dose (MTD) of ALED administration for mice and rats was over (400 g antipyrine plus 100 g lidocaine hydrochloride)/kg and (240 g andtipyrine plus 60 g lidocaine hydrochloride)/kg, respectively. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.01.018DOI Listing
April 2019
5 Reads
2.031 Impact Factor

Lidocaine for Cancer Pain in Adults: A Systematic Review and Meta-Analysis.

J Palliat Med 2019 Mar 7;22(3):326-334. Epub 2019 Jan 7.

1 Improving Palliative, Aged and Chronic Care Through Clinical Research and Translation, University of Technology Sydney, Ultimo, Australia.

Background: Internationally, use of lidocaine infusions to treat cancer pain varies by center. Existing systematic reviews do not adequately inform use of lidocaine in cancer pain.

Objective: To assess the effects of systemic sodium channel blockers on cancer pain in adults, review the dose protocols for administration, and assess toxicity. Read More

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http://dx.doi.org/10.1089/jpm.2018.0257DOI Listing
March 2019
1 Read

Victims of chemical terrorism, a family of four who were exposed to sulfur mustard.

Toxicol Lett 2019 Mar 17;303:9-15. Epub 2018 Dec 17.

University of Health Sciences, Dept. of Medical CBRN Defense, 06010, Etlik, Ankara, Turkey.

Sulfur mustard (SM) was responsible for more than 80% of all documented chemical casualties during the Great War. Recent literature on clinic picture of SM exposure remained so limited with the sporadic cases who were accidentally exposed to SM especially either in Western Europe or China. We reported a Syrian family of four who became victims of chemical terrorism due to SM exposure and we described the detailed clinical course of the family including the medical history, initial symptomatology, clinical examination, hematological data, and initial treatment in the first 48 hours after exposure at Kilis State Hospital, Turkey. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.12.006DOI Listing
March 2019
9 Reads

Cardiotoxicity of Consolida rugulosa, a poisonous weed in Western China.

Ecotoxicol Environ Saf 2019 Apr 5;170:141-147. Epub 2018 Dec 5.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Poisonous weeds are a global problem since they not only hinder local economic development, but also cause ecological harm. Consolida rugulosa (family Ranunculaceae) is a weed that is widespread in Northwestern China and causes severe poisoning when ingested by livestock. In the present study, we purified the toxins in this plant and investigated their mechanism of action. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183125
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http://dx.doi.org/10.1016/j.ecoenv.2018.11.109DOI Listing
April 2019
17 Reads

A Case of Takotsubo Cardiomyopathy After Local Anesthetic and Epinephrine Infiltration.

Cureus 2018 Aug 21;10(8):e3173. Epub 2018 Aug 21.

Anesthesia Institute, Cleveland Clinic Foundation - Fairview Hospital, Cleveland, USA.

Takotsubo cardiomyopathy (TC) is a non-ischemic cardiomyopathy that is accompanied by sudden left ventricular myocardial stunning, dilation and dysfunction. It often results from severe emotional or physical stress. We present the case of a 41-year-old female patient who had general anesthesia induced uneventfully for an elective bladder sling procedure. Read More

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https://www.cureus.com/articles/14242-a-case-of-takotsubo-ca
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http://dx.doi.org/10.7759/cureus.3173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197510PMC
August 2018
21 Reads

Lidocaine Use in Vaginal Surgery and Risk of Toxicity.

Female Pelvic Med Reconstr Surg 2018 Oct 19. Epub 2018 Oct 19.

From the Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, Chapel Hill, NC.

Objectives: The primary objective of this study was to compare the amount of lidocaine administered for vaginal reconstruction with versus without hysterectomy. The secondary objective was to assess the risk of lidocaine toxicity.

Methods: This retrospective cohort study compares lidocaine dose in 2 cohorts: women who underwent vaginal hysterectomy with additional vaginal reconstruction (VH + VR) versus those who underwent vaginal reconstruction without hysterectomy (VR only). Read More

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http://dx.doi.org/10.1097/SPV.0000000000000622DOI Listing
October 2018
22 Reads

Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model.

J Otolaryngol Head Neck Surg 2018 Oct 20;47(1):64. Epub 2018 Oct 20.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta, 2C3.57 Walter MacKenzie Centre, Edmonton, AB, T6G 2R7, Canada.

Background: Propofol and remifentanil intravenous combination is one popular form of total intravenous anesthesia (TIVA) in mainstream clinical practice, but it has rarely been applied to a rat model for laryngoscopy and laryngeal electromyography (LEMG). Our objective was to establish a safe and reproducible general anesthetic protocol for laryngoscopy and endoscopic LEMG in a rat model. Our hypothesis is that TIVA allows a minimally morbid, and feasible laryngoscopy and LEMG. Read More

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https://journalotohns.biomedcentral.com/articles/10.1186/s40
Publisher Site
http://dx.doi.org/10.1186/s40463-018-0312-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196000PMC
October 2018
5 Reads

Lidocaine-induced potentiation of thermal damage in skin and carcinoma cells.

Lasers Surg Med 2019 Jan 15;51(1):88-94. Epub 2018 Oct 15.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.

Objective: Lidocaine acts as a local anesthetic by blocking transmembrane sodium channel permeability, but also induces the synthesis of heat shock proteins and sensitizes cells to hyperthermia. A previous study reported two cases of deep focal skin ulceration at points corresponding to depot local lidocaine injection sites after treatment with non-ablative fractional resurfacing and it was hypothesized that lidocaine had focally sensitized keratinocytes to the thermal damage of laser treatment. The objective of this study was to investigate whether lidocaine potentiates hyperthermia damage to both normal and cancerous skin cells using an in vitro model. Read More

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http://dx.doi.org/10.1002/lsm.23027DOI Listing
January 2019
5 Reads

Preclinical Evaluation of Ropivacaine in 2 Liposomal Modified Systems.

Anesth Analg 2018 Oct 9. Epub 2018 Oct 9.

Laboratory of Inflammation, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil.

Background: Our research group has recently developed liposomes with ionic gradient and in a combined manner as donor and acceptor vesicles containing ropivacaine (RVC; at 2% or 0.75%). Looking for applications of such novel formulations for postoperative pain control, we evaluated the duration of anesthesia, pharmacokinetics, and tissue reaction evoked by these new RVC formulations. Read More

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http://Insights.ovid.com/crossref?an=00000539-900000000-9643
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http://dx.doi.org/10.1213/ANE.0000000000003837DOI Listing
October 2018
2 Reads

Dexmedetomidine ameliorates lidocaine-induced spinal neurotoxicity via inhibiting glutamate release and the PKC pathway.

Neurotoxicology 2018 12 18;69:77-83. Epub 2018 Sep 18.

Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China. Electronic address:

Dexmedetomidine, a selective α adrenergic agonist, has been shown to have neuroprotective and anti-apoptotic effects. To further investigate the underlying mechanisms, we used a rat model of spinal neurotoxicity induced by intrathecal administration of lidocaine. Four days after intrathecal catheter implantation, rats received an intraperitoneal injection of various doses of dexmedetomidine before an intrathecal injection of 20 μL 10% lidocaine. Read More

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http://dx.doi.org/10.1016/j.neuro.2018.09.004DOI Listing
December 2018
1 Read

Toxicity and Pharmacokinetic Studies of Lidocaine and Its Active Metabolite, Monoethylglycinexylidide, in Goat Kids.

Animals (Basel) 2018 Aug 20;8(8). Epub 2018 Aug 20.

School of Veterinary Science, Massey University, Tennent Drive, Palmerston North 4442, New Zealand.

This study determined the convulsant plasma concentrations and pharmacokinetic parameters following cornual nerve block and compared the results to recommend a safe dose of lidocaine hydrochloride for goat kids. The plasma concentrations of lidocaine and monoethylglycinexylidide (MGX) were quantified using liquid chromatography-mass spectrometry. A total dose of 7 mg/kg body weight (BW) was tolerated and should therefore be safe for local and regional anesthesia in goat kids. Read More

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http://dx.doi.org/10.3390/ani8080142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115778PMC
August 2018
2 Reads

Sodium Ferulate Attenuates Lidocaine-Induced Corneal Endothelial Impairment.

Oxid Med Cell Longev 2018 8;2018:4967318. Epub 2018 Jul 8.

Laboratory for Corneal Tissue Engineering, College of Marine Life Sciences, Ocean University of China, Yushan Road No. 5, Qingdao 266003, China.

The introduction of intracameral anaesthesia by injection of lidocaine has become popular in cataract surgery for its inherent potency, rapid onset, tissue penetration, and efficiency. However, intracameral lidocaine causes corneal thickening, opacification, and corneal endothelial cell loss. Herein, we investigated the effects of lidocaine combined with sodium ferulate, an antioxidant with antiapoptotic and anti-inflammatory properties, on lidocaine-induced damage of corneal endothelia with experiment of morphological changes and cell viability of cultured human corneal endothelial cells and investigation of corneal endothelial cell density and central corneal thickness of cat eyes. Read More

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http://dx.doi.org/10.1155/2018/4967318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079406PMC
December 2018
22 Reads

In Vivo Toxicity of Local Anesthetics and Corticosteroids on Supraspinatus Tenocyte Cell Viability and Metabolism.

Iowa Orthop J 2018 ;38:107-112

Department of Orthopaedic Surgery, University of Missouri, Columbia.

Background: This study was conducted to evaluate the effects of commonly used injection medication combinations on supraspinatus tenocyte cell viability and tissue metabolism.

Methods: Twenty adult dogs underwent ultrasound guided injection of the canine equivalent of the subacromial space, based on random assignment to one of four treatment groups (n=5/group): normal saline, 1.0% lidocaine/methylprednisolone, 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047373PMC
December 2018
6 Reads

An evaluation of crude palm oil (CPO) and tocotrienol rich fraction (TRF) of palm oil as percutaneous permeation enhancers using full-thickness human skin.

Pharm Dev Technol 2019 Apr 3;24(4):448-454. Epub 2018 Oct 3.

a School of Pharmacy , The University of Nottingham Malaysia Campus, Jalan Broga , Semenyih , Malaysia.

The drawbacks associated with chemical skin permeation enhancers such as skin irritation and toxicity necessitated the research to focus on potential permeation enhancers with a perceived lower toxicity. Crude palm oil (CPO) is obtained by direct compression of the mesocarp of the fruit of the oil palm belonging to the genus Elaeis. In this research, CPO and tocotrienol-rich fraction (TRF) of palm oil were evaluated for the first time as skin permeation enhancers using full-thickness human skin. Read More

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http://dx.doi.org/10.1080/10837450.2018.1509347DOI Listing
April 2019
29 Reads

Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model.

J Toxicol Sci 2018 ;43(8):493-506

Research Division, Chugai Pharmaceutical Co., Ltd.

We used motion field imaging to characterize the conduction and contraction of a sheet of cardiomyocytes derived from human induced pluripotent stem cells (hiPS-CMs). A hiPS-CMs sheet of 2.8 mm × 2. Read More

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http://dx.doi.org/10.2131/jts.43.493DOI Listing
August 2018
6 Reads

Basolateral amygdalar inactivation blocks chronic stress-induced lamina-specific reduction in prefrontal cortex volume and associated anxiety-like behavior.

Prog Neuropsychopharmacol Biol Psychiatry 2019 01 21;88:194-207. Epub 2018 Jul 21.

Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bengaluru 560 029, India. Electronic address:

Chronic exposure to stress causes cognitive deficits, anxiety and depression. Earlier studies have suggested that the prefrontal cortex (PFC) and basolateral amygdala (BLA) can differentially modulate the stress-induced alterations either by their action on HPA axis or via direct reciprocal connections between them. The PFC dysfunction and BLA hypertrophy following stress are known to cause anxiety and affective symptoms. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2018.07.016DOI Listing
January 2019
2 Reads

Factors associated with intravenous lidocaine in pediatric patients undergoing laparoscopic appendectomy - a retrospective, single-centre experience.

BMC Anesthesiol 2018 07 18;18(1):88. Epub 2018 Jul 18.

Department of Anesthesia, University Children's Hospital, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.

Background: Due to its potential beneficial effects, intra- and postoperative application of intravenous lidocaine has become increasingly accepted over the last couple of years, e.g. in patients undergoing laparoscopic surgical procedures. Read More

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http://dx.doi.org/10.1186/s12871-018-0545-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052565PMC
July 2018
16 Reads

Acute Lidocaine Toxicity; a Case Series.

Emerg (Tehran) 2018 16;6(1):e38. Epub 2018 Jun 16.

Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Parenteral form of lidocaine is the best-known source of lidocaine poisoning. This study aimed to evaluate the characteristics of acute lidocaine toxicity .

Methods: In this retrospective cross-sectional study, demographics, clinical presentation, laboratory findings, and outcome of patients intoxicated with lidocaine (based on ICD10 codes) admitted to Loghman Hakim Hospital, during April 2007 to March 2014 were analyzed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036540PMC
June 2018
17 Reads

Sub-muscular Breast Augmentation Using Tumescent Local Anesthesia.

Aesthetic Plast Surg 2019 Feb 11;43(1):7-13. Epub 2018 Jul 11.

Department of Surgical, Microsurgical and Medical Sciences, Plastic Surgery Unit, University of Sassari, Via Monte Grappa 70, 07100, Sassari, Italy.

Background: Tumescent local anesthesia (TLA) consists of infiltration of saline solution with lidocaine and epinephrine into the tissues to obtain regional anesthesia and vasoconstriction. The use of TLA in augmentation mammoplasty has been described for sub-glandular positioning. We describe a modified TLA technique for primary sub-muscular breast augmentation reporting our experience during the past 7 years. Read More

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http://dx.doi.org/10.1007/s00266-018-1181-3DOI Listing
February 2019
28 Reads

True Allergy to Amide Local Anesthetics: A Review and Case Presentation.

Anesth Prog 2018 ;65(2):119-123

PGY2 General Practice Chief Resident, NYU Lutheran, Brooklyn, New York.

Adverse reactions to local anesthetics are usually a reaction to epinephrine, vasovagal syncope, or overdose toxicity. Allergic reactions to local anesthetics are often attributed to additives such as metabisulfite or methylparaben. True allergic reactions to amide local anesthetics are extremely rare but have been documented. Read More

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http://dx.doi.org/10.2344/anpr-65-03-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022794PMC
January 2018
7 Reads

Topically Delivered Minocycline Penetrates a Full-Thickness Burn Eschar and Reduces Tissue Bacterial Counts.

J Burn Care Res 2018 Aug;39(5):790-797

Applied Tissue Technologies LLC, Hingham, MA.

Injuries to the skin are often complicated by invasive infections. Standard treatment with intravenous antibiotics has limited tissue penetration and sometimes, major systemic toxicity. Traditional topical delivery of antimicrobials also has limited effectiveness and duration of action. Read More

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http://dx.doi.org/10.1093/jbcr/irx051DOI Listing
August 2018
27 Reads

Acute Opioid-Induced Myoclonic Reaction after Use of Fentanyl as an Anesthetic Drug for an Emergency Cesarean Section.

Case Rep Neurol 2018 May-Aug;10(2):130-134. Epub 2018 May 30.

Department of Neurology, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.

Myoclonus is an abnormal involuntary movement that has been previously reported with administration of high doses of opioids for prolonged periods of time. In this case, however, we report an acute myoclonic reaction and review the literature on the possible causative pathophysiology. We report the case of a 24-year-old woman who was admitted for postdated cesarean section. Read More

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http://dx.doi.org/10.1159/000486891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006639PMC
May 2018
5 Reads

Participation of voltage-gated sodium and calcium channels in the acute cardiac effects of toluene.

Toxicol Mech Methods 2018 Nov 31;28(9):670-677. Epub 2018 Jul 31.

c Facultad de Ciencias Médicas y Biológicas "Dr. Ignacio Chávez" , Universidad Michoacana de San Nicolás de Hidalgo, Dr. Rafael Carrillo esquina Dr. Salvador González Herrejón, Col. Bosque Cuauhtémoc , Morelia , Mexico.

Inhaling solvents can lead to occurrence of cardiac arrhythmias and sudden sniffing death. Mechanisms related to this phenomenon are not fully understood. The purpose of this study was to investigate the effect of acute toluene exposure on heart reactivity to epinephrine and the participation of voltage-gated sodium and calcium channels. Read More

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http://dx.doi.org/10.1080/15376516.2018.1491664DOI Listing
November 2018
14 Reads

Population pharmacokinetic model for tumescent lidocaine in women undergoing breast cancer surgery.

Eur J Clin Pharmacol 2018 Oct 16;74(10):1309-1315. Epub 2018 Jun 16.

Service de Pharmacologie Clinique et Pharmacovigilance, Hôpital de la Timone, AP-HM, 13385, Marseille, France.

Purpose: Tumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocaine in a context of TLA during a unilateral mastectomy. The aim of this study was to describe lidocaine pharmacokinetics in elderly women undergoing breast cancer surgery after TLA and to explore the risk of the toxicity of this technique. Read More

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http://dx.doi.org/10.1007/s00228-018-2503-8DOI Listing
October 2018
13 Reads

Lidocaine toxicity in the setting of HeartMate II left ventricular assist device.

J Clin Pharm Ther 2018 Oct 9;43(5):733-736. Epub 2018 Jun 9.

East Carolina Heart Institute at ECU, Greenville, NC, USA.

What Is Known And Objective: Lidocaine infused at 1-4 mg/min is an appropriate treatment modality for hemodynamically stable ventricular tachycardia (VT) with normal hepatic function. A case of acute lidocaine toxicity in the setting of left ventricular assist device (LVAD) is reported.

Case Summary: A 71-year-old with a HeartMate II LVAD on chronic mexiletine and normal liver function presented with ventricular tachycardia requiring systemic lidocaine and subsequently developed altered mental status with tremors. Read More

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http://dx.doi.org/10.1111/jcpt.12717DOI Listing
October 2018
8 Reads

The return of an old nemesis: Survival after severe tricyclic antidepressant toxicity, a case report.

Authors:
Al Giwa Edwin Oey

Toxicol Rep 2018 10;5:357-362. Epub 2018 Mar 10.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029-6574, United States.

Tricyclic antidepressants (TCAs) were first approved by the Food and Drug Administration (FDA) for use as antidepressants in the 1950s. Although their function as an antidepressant in the U.S. Read More

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http://dx.doi.org/10.1016/j.toxrep.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977411PMC
March 2018
16 Reads

[Pain therapy in intensive care patients].

Anaesthesist 2018 Jun;67(6):401-408

Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Am Klinikum 1, 07740, Jena, Deutschland.

After intensive care unit (ICU) treatment, the recollection of experienced pain is one of the most burdensome aftermaths. In addition, pain has several negative physiological consequences. The majority of patients report moderate to severe pain while being treated on an ICU, often caused by diagnostic or therapeutic procedures. Read More

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http://dx.doi.org/10.1007/s00101-018-0458-xDOI Listing
June 2018
4 Reads

Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization.

Authors:
Oleg E Osadchii

Scand Cardiovasc J 2018 08 25;52(4):218-226. Epub 2018 May 25.

a Department of Biomedical Sciences , University of Copenhagen , Copenhagen , Denmark.

Objectives: In normal conditions, sudden heart rate acceleration provokes a rapid reduction in ventricular action potential duration (APD). The protracted APD rate adaptation favors early afterdepolarizations and precipitates arrhythmia. Nevertheless, it is uncertain as to whether the rate-dependent changes of ventricular repolarization can be adversely modified by arrhythmogenic drugs (quinidine and procainamide) and hypokalemia, in comparison to the agents with safe therapeutic profile, such as lidocaine. Read More

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http://dx.doi.org/10.1080/14017431.2018.1478123DOI Listing
August 2018
5 Reads

Poisoning associated with inappropriate use of a eutectic mixture of lidocaine and prilocaine before laser-assisted hair removal: about 3 cases.

Int J Legal Med 2019 May 21;133(3):843-846. Epub 2018 May 21.

Centre antipoison et de toxicovigilance de Paris, hôpital Fernand-Widal, Paris, France.

Background: Eutectic mixtures of lidocaine and prilocaine are used during painful dermatological procedures. Poisoning is rarely reported in adults.

Material And Method: We report three cases of women who experienced lidocaine and prilocaine poisoning after laser-assisted hair removal. Read More

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http://dx.doi.org/10.1007/s00414-018-1858-9DOI Listing
May 2019
26 Reads

Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain.

Neuroscience 2018 06;381:149-158

Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States; Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, United States. Electronic address:

Latent sensitization is a model of chronic pain in which an injury triggers a period of hyperalgesia followed by an apparent recovery, but in which pain sensitization persists but is suppressed by opioid and adrenergic receptors. One important characteristic of latent sensitization is that hyperalgesia can be triggered by acute stress. To determine whether the effect of stress is mimicked by the activation of corticotropin-releasing factor (CRF) signaling in the brain, rats with latent sensitization induced by injecting complete Freund's adjuvant (CFA, 50 μl) in one hind paw were given an intracerebroventricular (i. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962032PMC
June 2018
1 Read

Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety.

Pain 2018 Sep;159(9):1696-1704

Royal Perth Hospital, Perth, Western Australia, Australia.

Chronic postsurgical pain (CPSP) occurs in 12% of surgical populations and is a high priority for perioperative research. Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify and synthesize the evidence linking lidocaine infusions and CPSP. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001273DOI Listing
September 2018

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia.

J Neuroinflammation 2018 Mar 24;15(1):94. Epub 2018 Mar 24.

Department of Physiology and Pharmacology, "Vittorio Erspamer", La Sapienza University of Rome, 00185, Rome, Italy.

Background: Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity. EGCs regulate intestinal inflammatory responses by secreting pro-inflammatory molecules; nonetheless, they might also release immune-regulatory factors, as palmytoilethanolamide (PEA), which exerts anti-inflammatory effects by activating PPARα receptors. Read More

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http://dx.doi.org/10.1186/s12974-018-1126-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866515PMC
March 2018
5 Reads

Impact of Scyphozoan Venoms on Human Health and Current First Aid Options for Stings.

Toxins (Basel) 2018 03 23;10(4). Epub 2018 Mar 23.

Institute of Pharmacology and Toxicology, Paracelsus Medical University, Strubergasse 21, A-5020 Salzburg, Austria.

Cnidaria include the most venomous animals of the world. Among Cnidaria, Scyphozoa (true jellyfish) are ubiquitous, abundant, and often come into accidental contact with humans and, therefore, represent a threat for public health and safety. The venom of Scyphozoa is a complex mixture of bioactive substances-including thermolabile enzymes such as phospholipases, metalloproteinases, and, possibly, pore-forming proteins-and is only partially characterized. Read More

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http://www.mdpi.com/2072-6651/10/4/133
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http://dx.doi.org/10.3390/toxins10040133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923299PMC
March 2018
18 Reads

Are surgeons overdosing patients with lidocaine?

Am J Otolaryngol 2018 May - Jun;39(3):370-371. Epub 2018 Mar 14.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Head and Neck Surgery, Boston University School of Medicine, Boston, MA 02118, United States; The Spiegel Center, Newton, MA 02459, United States. Electronic address:

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http://dx.doi.org/10.1016/j.amjoto.2018.03.023DOI Listing
March 2018
4 Reads

Combining Ultrasound-Guided Vascular Access With Ultrasound-Guided Analgesia for Single Skin and Vessel Puncture.

J Endovasc Ther 2018 Jun 12;25(3):355-357. Epub 2018 Mar 12.

1 Department of Radiology, Beaumont Hospital, Dublin, Ireland.

Purpose: To describe a single skin puncture technique combining subcutaneous injection of anesthetic to the depth of the vessel wall with venipuncture in the same movement.

Technique: Using ultrasound guidance, controlled anesthetic instillation along the needle tract and outer vessel wall with a 21-G vascular access needle can be combined with vessel puncture. This technique reduces the number of skin punctures and ensures accurate anesthetic instillation. Read More

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http://dx.doi.org/10.1177/1526602818761380DOI Listing
June 2018
7 Reads

Local Anesthetic Systemic Toxicity Induced Cardiac Arrest After Topicalization for Transesophageal Echocardiography and Subsequent Treatment With Extracorporeal Cardiopulmonary Resuscitation.

J Cardiothorac Vasc Anesth 2019 01 31;33(1):162-165. Epub 2018 Jan 31.

Department of Surgery, University of Utah, Salt Lake City, UT; Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT; Division of Emergency Medicine, University of Utah, Salt Lake City, UT. Electronic address:

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http://dx.doi.org/10.1053/j.jvca.2018.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068002PMC
January 2019
8 Reads

Following-up skin penetration of lidocaine from different vehicles by Raman spectroscopic mapping.

J Pharm Biomed Anal 2018 May 6;154:1-6. Epub 2018 Mar 6.

Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, H-6720, Hungary. Electronic address:

The application of local anesthetics, usually administered by subcutaneous injection, is common in the course of diagnostic, therapeutic, and cosmetic dermatology procedures. The effective dermal delivery of lidocaine could offer a solution to many adverse effects caused by needle insertion, such as pain, local reactions or toxicity, and additionally, it avoids the disruption of anatomical landmarks. Therefore, novel dermal formulations of local anesthetics are needed to overcome the barrier function of the skin and provide sufficient and prolonged anesthesia. Read More

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http://dx.doi.org/10.1016/j.jpba.2018.02.056DOI Listing
May 2018
50 Reads

Local Anesthetic Systemic Toxicity Complicating Thyroid Biopsy.

Cureus 2017 Dec 16;9(12):e1955. Epub 2017 Dec 16.

Department of Medicine, Oregon Health and Science University, Portland, Oregon.

The overdiagnosis of thyroid malignancies may be contributing to the increased incidence of these cancers with a relatively stable mortality rate. We present the case of a man with known malignancies, who underwent biopsy of a suspicious thyroid nodule. This procedure was complicated by local anesthetic systemic toxicity (LAST). Read More

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http://dx.doi.org/10.7759/cureus.1955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815651PMC
December 2017
2 Reads