28,991 results match your criteria Toxicity Lead


N-acetylcysteine alleviated bisphenol A-induced testicular DNA hypermethylation of rare minnow (Gobiocypris rarus) by increasing cysteine contents.

Ecotoxicol Environ Saf 2019 Feb 14;173:243-250. Epub 2019 Feb 14.

College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China. Electronic address:

Ubiquitous BPA exposure resulted in DNA methylation errors and oxidative stress. Numerous studies have demonstrated that oxidative stress can lead to changes in DNA methylation levels and supplementation with antioxidants, including N-acetylcysteine (NAC), was able to restore these changes. Our previous study supposed that BPA-induced de novo synthesis of glutathione (GSH) promoted DNA methylation process in Gobiocypris rarus testes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193018
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http://dx.doi.org/10.1016/j.ecoenv.2019.02.035DOI Listing
February 2019

The antagonistic effect of Se on the Pb-weakening formation of neutrophil extracellular traps in chicken neutrophils.

Ecotoxicol Environ Saf 2019 Feb 14;173:225-234. Epub 2019 Feb 14.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Neutrophils represent an important part of the body's innate immunity and can resist the invasion of pathogenic microorganisms by releasing neutrophil extracellular traps (NETs). In this study, we investigated the toxic effects of lead (Pb) on the release of NETs, the antagonism of selenium (Se) on Pb toxicity and the potential molecular mechanisms. Our model was an in vitro exposure model for the addition of Se, Pb or both in the culture medium and was based on the separation of neutrophils from the peripheral blood of healthy chickens. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.033DOI Listing
February 2019

Lead induces oxidative stress in Pisum sativum plants and changes the levels of phytohormones with antioxidant role.

Plant Physiol Biochem 2019 Feb 11;137:121-129. Epub 2019 Feb 11.

Department of Biology & LAQV-REQUIMTE-UP, Faculty of Sciences, University of Porto, Rua Campo Alegre, 4169-007, Porto, Portugal.

The interaction of lead (Pb) with plant hormonal balance and oxidative stress remains under discussion. To evaluate how Pb induces oxidative stress, and modulates the antioxidant enzymes and the phytohormones pool, four-week old Pisum sativum plants were exposed during 28 days to 10, 100 and 500 mg kg Pb in soil. In comparison to leaves, roots showed higher Pb accumulation, oxidative damages and changes in phytohormone pools. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.02.005DOI Listing
February 2019

Analysis of acidic organo(fluoro)phosphates as decomposition product of lithium ion battery electrolytes via derivatization gas chromatography-mass spectrometry.

J Chromatogr A 2019 Feb 11. Epub 2019 Feb 11.

University of Münster, MEET Battery Research Center, Corrensstraße 46, 48149, Münster, Germany. Electronic address:

Nowadays, lithium ion batteries (LIBs) are the preferred energy supply for consumer electronics and electric vehicles. But, intrinsic reactions in the LIB system lead to a reduced battery life and impaired safety properties. Organo(fluoro)phosphates (O(F)Ps) as decomposition product of the conducting salt and the organic carbonate solvent molecules of the LIB electrolyte are of high interest due to structural similarities to chemical warfare agents and therefore a supposedly high toxicity. Read More

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http://dx.doi.org/10.1016/j.chroma.2019.02.022DOI Listing
February 2019

In vitro toxicity assessment of zinc and nickel ferrite nanoparticles in human erythrocytes and peripheral blood mononuclear cell.

Toxicol In Vitro 2019 Feb 13;57:54-61. Epub 2019 Feb 13.

Nanobiology Laboratory, Department of Natural and Exact Sciences, Pontificia Universidad Católica Madre y Maestra, PUCMM, Autopista Duarte Km 1 ½, Santiago de los Caballeros, Dominican Republic. Electronic address:

Ferrite nanoparticles (NPs) have gained attention in biomedicine due to their many potential applications, such as targeted drug delivery, their use as contrast agents for magnetic resonance imaging and oncological treatments. The information about the risk effects of ferrite NPs in human blood cells is, however, scarce. To assess their potential toxicity, in vitro studies were carried out with magnetite and zinc, nickel and nickel‑zinc ferrites NPs at different concentrations (50, 100 and 200 μg·ml). Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.011DOI Listing
February 2019

Risk-based prediction of metal toxicity in sediment and impact on human health due to consumption of seafood (Saccostrea cucullata) found in two highly industrialised coastal estuarine regions of Eastern India: a food safety issue.

Environ Geochem Health 2019 Feb 15. Epub 2019 Feb 15.

Environment and Sustainability Department, CSIR-Institute of Minerals and Materials Technology, Bhubaneswar, India.

Estuarine ecosystems of the Bay of Bengal, India, are considered as the most productive environment, which have been persistently threatened by substantial anthropogenic activity. This study aims to investigate the metal contamination in the sediment of two estuaries and possible biomagnifications in the indigenous edible oyster Saccostrea cucullata and related health hazards due to its consumption. The accumulative ecological risks indicated that the sediment is moderate to strongly contaminated with cadmium and lead. Read More

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http://dx.doi.org/10.1007/s10653-019-00251-4DOI Listing
February 2019

Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens.

Hum Genomics 2019 Feb 15;13(1):10. Epub 2019 Feb 15.

Department of Biology, Miami University, Oxford, OH, 45056, USA.

Background: Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line more or less appropriate for particular studies. The purpose of this work encompasses both a review of transgenes that lead to the expression of Cre recombinase in the lens and a comparative analysis of currently available transgenic lines with a particular emphasis on the Le-Cre and P0-3.9GFPCre lines that can mediate DNA deletion in the lens placode. Read More

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http://dx.doi.org/10.1186/s40246-019-0192-8DOI Listing
February 2019

Strategies to inhibit arsenic trioxide-induced cardiotoxicity in acute promyelocytic leukemia.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Arsenic trioxide (ATO) is a drug commonly used for the treatment of acute promyelocytic leukemia (APL). Although ATO has been shown to cause significant improvement in patients, it is associated with serious side effects, which sometimes lead to the patient's death. In this review paper, we examine the reports of ATO-induced cardiotoxicity in APL patients and evaluate the strategies to reduce the incidence of such toxicity. Read More

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http://dx.doi.org/10.1002/jcp.28292DOI Listing
February 2019

Alveolar-Capillary Membrane-Related Pulmonary Cells as a Target in Endotoxin-Induced Acute Lung Injury.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Physiology and Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.

The main function of the lungs is oxygen transport from the atmosphere into the blood circulation, while it is necessary to keep the pulmonary tissue relatively free of pathogens. This is a difficult task because the respiratory system is constantly exposed to harmful substances entering the lungs by inhalation or via the blood stream. Individual types of lung cells are equipped with the mechanisms that maintain pulmonary homeostasis. Read More

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http://dx.doi.org/10.3390/ijms20040831DOI Listing
February 2019

Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-]thiazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Based on the analysis of epidermal growth factor receptor (EGFR) complexes with gefitinib with molecular docking, the scaffold-hopping strategy, combination of the active substructures, and structural optimization of EGFR inhibitors, a novel series of benzo[4,5]imidazo[2,1-]thiazole derivatives was designed, synthesized, and evaluated for antitumor activity in human cancer cell lines and cellular toxicity against human normal cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay and EGFR inhibitory activities in vitro. Some target compounds such as 2-(benzo[4,5]imidazo[2,1-]thiazol-3-yl)-N-(2-hydroxyphenyl)acetamide () and 2-(benzo[4,5]imidazo[2,1-]thiazol-3-yl)-N-(naphthalen-1-yl)acetamide () have shown significant antitumor activity against the EGFR high-expressed human cell line HeLa. All the target compounds showed hardly any antitumor activity against the EGFR low-expressed human cell line HepG2, and nearly no cellular toxicity against the human normal cell lines HL7702 and human umbilical vein endothelial cell lines (HUVEC). Read More

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http://dx.doi.org/10.3390/molecules24040682DOI Listing
February 2019

Effect of ageing and chemical form on the bioavailability and toxicity of Pb to the survival and reproduction of the soil invertebrate Enchytraeus crypticus.

Sci Total Environ 2019 Feb 5;664:975-983. Epub 2019 Feb 5.

Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands. Electronic address:

This study investigated the effect of ageing on the bioavailability and toxicity of lead nitrate (Pb(NO)) and lead oxide (PbO) to Enchytraeus crypticus in LUFA 2.2 natural soil. The potworms were exposed after 2 weeks pre-incubation and after ageing the spiked soils for 3, 6, 12 and 18 months. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.054DOI Listing
February 2019

Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice.

Food Funct 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China. and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China and National Engineering Research Centre for Functional Food, Wuxi, Jiangsu 214122, China and Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.

The management of lead (Pb) exposure and toxicity remains a major public health priority worldwide. In our previous study, the probiotic strain Lactobacillus plantarum CCFM8661 prevented Pb absorption in mice via intestinal sequestration. This follow-up study aimed to evaluate the additional protective mechanism of L. Read More

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http://dx.doi.org/10.1039/c8fo02554aDOI Listing
February 2019

RbAgBiBr: A Lead-Free Visible Light Absorbing Halide Semiconductor with Improved Stability.

Inorg Chem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.

Replacement of the toxic heavy element lead in metal halide perovskites has been attracting a great interest because the high toxicity and poor air stability are two of the major barriers for their widespread utilization. Recently, mixed-cation double perovskite halides, also known as elpasolites, were proposed as an alternative lead-free candidate for the design of nontoxic perovskite solar cells. Herein, we report a new nontoxic and air stable lead-free all-inorganic semiconductor RbAgBiBr prepared using the mixed-cation approach; however, RbAgBiBr adopts a new structure type (Pearson's code oP32) featuring BiBr octahedra and AgBr square pyramids that share common edges and corners to form a unique 2D layered non-perovskite structure. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03623DOI Listing
February 2019

Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig.

Biomed Res Int 2019 15;2019:3626032. Epub 2019 Jan 15.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.

Lead exposure causes or aggravates hearing damage to human or animal, but the detailed effects of lead exposure on auditory system including injury sites of the cochlea in mammal remain controversy. To investigate the effect of chronic lead exposure on auditory system, 40 adult guinea pigs with normal hearing were randomly divided into five groups. They were fed 2 mmol/L lead acetate in drinking water for 0, 15, 30, 60, and 90 days (n = 8), respectively. Read More

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http://dx.doi.org/10.1155/2019/3626032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350542PMC
January 2019

Inhalation of Bacterial Cellulose Nanofibrils Triggers an Inflammatory Response and Changes Lung Tissue Morphology of Mice.

Toxicol Res 2019 Jan 15;35(1):45-63. Epub 2018 Jan 15.

CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal.

In view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by . Murine bone marrow-derived macrophages (BMMΦ) were treated with different doses of nBC (0. Read More

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http://dx.doi.org/10.5487/TR.2019.35.1.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354950PMC
January 2019

Decreased erythrocyte CD44 and CD58 expression link e-waste Pb toxicity to changes in erythrocyte immunity in preschool children.

Sci Total Environ 2019 Feb 5;664:690-697. Epub 2019 Feb 5.

Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, Guangdong, China. Electronic address:

Lead (Pb) toxicity damages blood cells and disturbs the immune micro-environment. When Pb enters the circulatory system, >95% of Pb accumulates in erythrocytes. We therefore conducted this study to explore the long-term effect of Pb exposure on expression of erythrocyte adhesion molecules (CD44 and CD58) and related downstream cytokine concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.040DOI Listing
February 2019

Discovery of NDM-1 inhibitors from natural products.

J Glob Antimicrob Resist 2019 Feb 11. Epub 2019 Feb 11.

School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Objectives: Human health is seriously threatened by metallo-beta-lactamase(MBL)-mediated bacterial resistance. Among them, the New Delhi metallo-beta-lactamase-1(NDM-1) has received great attention due to its extensive substrate specificity and high lateral gene transfer. Currently there is no inhibitor of NDM-1 available in clinical therapy, thus making an argent need for the research and development of novel NDM-1 inhibitors. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.02.003DOI Listing
February 2019

Growth performance, biochemical, cytological and molecular aspects of rabbits exposed to lead toxicity.

J Anim Physiol Anim Nutr (Berl) 2019 Feb 13. Epub 2019 Feb 13.

Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Heavy metals have enormous variety of deleterious effects on many organs in the body. This study demonstrated the toxic influences of lead on the growth, biochemical, cellular and molecular aspects of developing rabbits. Seventy-five rabbits (New Zealand NZW) were divided into five equal groups as follows; control (C) and four treatment groups (T1-4) orally administered lead acetate solution as follow T1: 20, T2: 30, T3: 50 and T4: 70 mg/kg body weight. Read More

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http://dx.doi.org/10.1111/jpn.13073DOI Listing
February 2019

Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention.

Cancer Prev Res (Phila) 2019 Feb 13. Epub 2019 Feb 13.

Pharmacology and Toxicology, Michigan State University

Rexinoids, selective ligands for retinoid X receptors (RXRs), have shown promise in preventing many types of cancer. However, the limited efficacy and undesirable lipidemic side-effects of the only clinically approved rexinoid, bexarotene, drive the search for new and better rexinoids. Here we report the evaluation of novel pyrimidinyl (Py) analogs of two known chemopreventive rexinoids, bexarotene (Bex) and LG100268 (LG268) in a new paradigm. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0317DOI Listing
February 2019

Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors.

Authors:
Leif E Peterson

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York City, NY 10065, USA.

Natural and synthetic small molecules from the NCI Developmental Therapeutics Program (DTP) were employed in molecular dynamics-based docking with DNA repair proteins whose RNA-Seq based expression was associated with overall cancer survival (OS) after adjustment for the metagene. The compounds employed were required to elicit a sensitive response (vs. resistance) in more than half of the cell lines tested for each cancer. Read More

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http://dx.doi.org/10.3390/molecules24030645DOI Listing
February 2019

Heavy metal pollution and potential health risks of commercially available Chinese herbal medicines.

Sci Total Environ 2019 Feb 30;653:748-757. Epub 2018 Oct 30.

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

A survey was conducted to investigate the pollution and health risks of copper (Cu), cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and zinc (Zn) in 60 Chinese herbal medicines (CHMs) collected from a market in Kunming City, Yunnan Province, China. Furthermore, eight CHMs (Cyathulae radix, Drynariae rhizoma, Peucedani radix, Homalomenae rhizoma, Dryopteris setosa, Polygonati rhizoma, Lilii bulbus, and Linderae radix) containing high Cd concentrations were selected to further analyse their Cd chemical forms. Additionally, the dissolution rates of six heavy metals in decoction liquid were also analysed for four CHMs (Typhonii rhizoma, Linderae radix, Homalomenae rhizoma, and Cyathulae radix), and the health risks of heavy metals in CHMs were evaluated. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.388DOI Listing
February 2019

Di(2-ethylhexyl)phthalate induces reproductive toxicity via JAZF1/TR4 pathway and oxidative stress in pubertal male rats.

Toxicol Ind Health 2019 Feb 12:748233718824911. Epub 2019 Feb 12.

2 School of Environment, Tsinghua University, Beijing, People's Republic of China.

Di(2-ethylhexyl)phthalate (DEHP) is a typical endocrine-disrupting chemical and reproductive toxicant. Although previous studies have attempted to describe the mechanism by which DEHP exposure results in reproductive dysfunction, few studies focused on puberty, a critical period of reproductive development, and the increased susceptibility to injury in adolescents. To elucidate the mechanism underpinning the testicular effects of DEHP in puberty, we sought to investigate the JAZF1/TR4 pathway in the testes of pubertal rats. Read More

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http://dx.doi.org/10.1177/0748233718824911DOI Listing
February 2019
1.710 Impact Factor

Altered cord blood mitochondrial DNA content and pregnancy lead exposure in the PROGRESS cohort.

Environ Int 2019 Feb 9;125:437-444. Epub 2019 Feb 9.

Department of Environmental Health Sciences, Columbia University, Mailman School of Public Health, New York, NY, USA. Electronic address:

Introduction: Lead (Pb) crosses the placenta and can cause oxidative stress, reduced fetal growth and neurological problems. The principal source of oxidative stress in human cells is mitochondria. Therefore, disruption of normal mitochondrial function during pregnancy may represent a primary mechanism behind the adverse effects of lead. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.077DOI Listing
February 2019
6 Reads

Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes.

J Neurovirol 2019 Feb 11. Epub 2019 Feb 11.

Department of Immunology and Nano-medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA.

Accelerated neurological disorders are increasingly prominent among the HIV-infected population and are likely driven by the toxicity from long-term use of antiretroviral drugs. We explored potential side effects of antiretroviral drugs in HIV-infected primary human astrocytes and whether opioid co-exposure exacerbates the response. HIV-infected human astrocytes were exposed to the reverse transcriptase inhibitor, emtricitabine, alone or in combination with two protease inhibitors ritonavir and atazanavir (ERA) with and without morphine co-exposure. Read More

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http://dx.doi.org/10.1007/s13365-018-0715-4DOI Listing
February 2019
1 Read

Impact of engineered nanoparticles on microbial transformations of carbon, nitrogen, and phosphorus in wastewater treatment processes - A review.

Sci Total Environ 2019 Apr 11;660:1144-1154. Epub 2019 Jan 11.

Department of Bioscience, Aarhus University, Aarhus 8000C, Denmark.

Concern regarding the potential negative impacts of released engineered nanoparticles (ENPs) on pollutant removal performance of wastewater treatment systems has received booming attention in recent years. However, the conclusions drawn from different studies often lead to fragmented overall knowledge, some of which are even contradictory. This scenario shows the necessity for a comprehensive review of the interactions of ENPs in wastewater treatment systems, particularly on the impacts of ENPs on microbial processes of carbon (C), nitrogen (N), and phosphorus (P) removal in water treatment systems. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.106DOI Listing

Selective, Fast-Response, and Regenerable Metal-Organic Framework for Sampling Excess Fluoride Levels in Drinking Water.

J Am Chem Soc 2019 Feb 11. Epub 2019 Feb 11.

Laboratory of Molecular Simulation (LSMO) and ‡Electronic Workshop, Institut des Sciences et Ingénierie Chimiques (ISIC) , Ecole Polytechnique Fédérale de Lausanne (EPFL Valais) , Rue de l'Industrie 17 , 1951 Sion , Switzerland.

Prolonged consumption of water contaminated with fluoride ions (F) at concentrations exceeding 1.5 ppm can lead to considerable health implications, particularly in children and developing embryos. With irreversible and potentially severe forms of fluoride (F) toxicity such as skeletal fluorosis being endemic in at least 25 countries, constructing affordable, remote-access, reliable water-sampling methods for F contamination is an important goal. Read More

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http://dx.doi.org/10.1021/jacs.8b11907DOI Listing
February 2019
1 Read

Pulmonary Oxygen Toxicity in Navy Divers: A Crossover Study Using Exhaled Breath Analysis After a One-Hour Air or Oxygen Dive at Nine Meters of Sea Water.

Front Physiol 2019 25;10:10. Epub 2019 Jan 25.

Department of Anaesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Exposure to hyperbaric hyperoxic conditions can lead to pulmonary oxygen toxicity. Although a decrease in vital capacity has long been the gold standard, newer diagnostic modalities may be more accurate. In pulmonary medicine, much research has focussed on volatile organic compounds (VOCs) associated with inflammation in exhaled breath. Read More

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http://dx.doi.org/10.3389/fphys.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355711PMC
January 2019
1 Read

Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors.

Eur J Med Chem 2019 Feb 5;166:480-501. Epub 2019 Feb 5.

Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. Electronic address:

The capsid assembly is an essential step for Hepatitis B Virus (HBV) life cycle and is an important target for anti-HBV drug development. In this report, we identified a hit compound with aminothiazole structure by the high throughput screening (HTS) which inhibited the interaction of HBV capsid protein within the cells. The structure hopping and SAR studies of the hit compound afforded compound 79 with potent anti-HBV replication activity and good basic drug-like properties. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.059DOI Listing
February 2019
1 Read

Severe toxicity in adult patients with lung cancer under treatment with pemetrexed: a prospective cohort study.

J Chemother 2019 Feb 10:1-10. Epub 2019 Feb 10.

a Clinical Pharmacology Section, Internal Medicine Department , Hospital Italiano de Buenos Aires, Buenos Aires , Argentina.

Pemetrexed is an antimetabolite approved for treatment of non-small cell lung cancer. Harbouring interindividual variability in both the pharmacokinetic and pharmacogenetic profiles may lead to life-threatening toxicities. A prospective cohort study of adult patients initiating treatment with pemetrexed in combination with platinum between 2013 and 2015 were follow up. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1572287DOI Listing
February 2019
1 Read

Synthesis of 2-,4,-6-, and/or 7-substituted quinoline derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents: 3D QSAR-assisted design.

Bioorg Med Chem Lett 2019 Jan 31. Epub 2019 Jan 31.

Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad 382481, Gujarat, India.

Following our research for human dihydroorotate dehydrogenase (hDHODH) inhibitors as anticancer agents, herein we describe 3D QSAR-based design, synthesis and in vitro screening of 2-,4,-6-, and/or 7-substituted quinoline derivatives as hDHODH inhibitors and anticancer agents. We have designed 2-,4,-6-, and/or 7-substituted quinoline derivatives and predicted their hDHODH inhibitory activity based on 3D QSAR study on 45 substituted quinoline derivatives as hDHODH inhibitors, and also predicted toxicity. Designed compounds were docked into the binding site of hDHODH. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.01.038DOI Listing
January 2019

Preventive effect of TiO nanoparticles on heavy metal Pb-induced toxicity in human lung epithelial (A549) cells.

Toxicol In Vitro 2019 Feb 6;57:18-27. Epub 2019 Feb 6.

King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Wide application of TiO nanoparticles (nTiO) and ubiquitous lead (Pb) pollution in natural environment enhance the chance of co-exposure of humans to Pb and nTiO. We investigated the effects of nTiO on Pb-induced toxicity in human lung epithelial (A549) cells. Results showed that nTiO was not toxic to A549 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183077
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http://dx.doi.org/10.1016/j.tiv.2019.02.004DOI Listing
February 2019
4 Reads

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease.

Molecules 2019 Feb 7;24(3). Epub 2019 Feb 7.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer's disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To address the multifactorial nature and complexity of AD, a multi-target-directed ligand approach was herein employed, by designing a set of six selected hybrids (⁻) that combine in the same entity two pharmacophores: tacrine (TAC) and 2-phenylbenzothiazole (PhBTA). The compounds contain a methoxy substituent at the PhBTA moiety and have a variable length linker between that and the TAC moiety. Read More

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http://dx.doi.org/10.3390/molecules24030587DOI Listing
February 2019
1 Read

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Food Chem Toxicol 2019 Feb 5;126:1-6. Epub 2019 Feb 5.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.004DOI Listing
February 2019
1 Read

The performance of vetivers (Chrysopogon zizaniodes and Chrysopogon nemoralis) on heavy metals phytoremediation: laboratory investigation.

Int J Phytoremediation 2019 Feb 8:1-10. Epub 2019 Feb 8.

c Center of Excellence on Hazardous Substance Management (HSM) , Bangkok , Thailand.

Phytoremediation with vetiver was investigated in relation to heavy metal contaminated soil in Thailand. The work compared the performance of two species of vetiver named Songkhla 3 (Chrysopogon zizaniodes) and Prachuap Khiri Khan (Chrysopogon nemoralis) in absorbing lead, zinc, and cadmium in contaminated soils. Toxicity Characteristic Leaching Procedure (TCLP), and Allium tests were conducted to determine toxicity of treated soil. Read More

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http://dx.doi.org/10.1080/15226514.2018.1546275DOI Listing
February 2019
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Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures.

Front Neurosci 2018 24;12:1053. Epub 2019 Jan 24.

Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.

Long-term alcohol use can lead to alterations in brain structure and functions and, in some cases, to neurodegeneration. Several mechanisms have been proposed to explain ethanol (EtOH)-related brain injury. One of the most relevant mechanisms of alcohol-induced neurodegeneration involves glutamatergic transmission, but their exact role is not yet fully understood. Read More

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http://dx.doi.org/10.3389/fnins.2018.01053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353783PMC
January 2019
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Countering the effects of lead as an environmental toxicant on the microanatomy of female reproductive system of adult wistar rats using aqueous extract of Ficus vogelii.

J Trace Elem Med Biol 2019 Mar 31;52:192-198. Epub 2018 Dec 31.

Department of Anatomy, Faculty of Basic medical Sciences, University of Nigeria Enugu Campus (UNEC), Enugu State, Nigeria.

Background: Lead without nutritional value is a widely studied occupational and environmental toxicant. Leads' toxic effects on female reproduction are decreased fertility, inability to sustain pregnancy and reduced pregnancy.

Objective: This study aimed at examining the effect of oral administration of lead acetate (1. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.016DOI Listing
March 2019
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Effect of percolation and chemical form on Pb bioavailability and toxicity to the soil invertebrate Enchytraeus crypticus in freshly spiked and aged soils.

Environ Pollut 2019 Jan 25;247:866-873. Epub 2019 Jan 25.

Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands. Electronic address:

In standard terrestrial ecotoxicological tests, soils usually are spiked with highly soluble metal salts leading to overestimation of bioavailability and introducing counterions that may contribute to toxicity. Leaching is suggested as an efficient method to avoid the effects of the associated counterions. The present study aimed at investigating the effects of leaching on the bioavailability and toxicity of Pb(NO) and PbO to the potworm Enchytraeus crypticus in LUFA 2. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.089DOI Listing
January 2019

Determination of lead levels in maternal and umbilical cord blood at birth at the Lagos University Teaching Hospital, Lagos.

PLoS One 2019 7;14(2):e0211535. Epub 2019 Feb 7.

Department of Paediatrics, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.

Background: Lead toxicity is a cause of intellectual disability in children and majority of affected children live in developing countries. Its adverse effect on pregnancy outcome has also been documented.

Objectives: To assess the relationship between maternal blood lead levels and umbilical cord blood lead levels in their corresponding newborn infants; to determine factors associated with high blood lead levels and the pregnancy outcome in participants. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211535PLOS
February 2019
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Trace element concentrations in feathers of seven petrels (Pterodroma spp.).

Environ Sci Pollut Res Int 2019 Feb 7. Epub 2019 Feb 7.

Institute for Marine and Antarctic Studies, University of Tasmania, 20 Castray Esplanade, Battery Point, Hobart, Tasmania, 7004, Australia.

Gadfly petrels (Pterodroma spp.) are one of the most threatened and poorly studied seabird groups, and as marine predators, are exposed to biomagnified and bioaccumulated chemical pollutants from their prey. We quantified trace element concentrations in breast feathers of seven petrel species that breed in the southern hemisphere to quantify current concentrations. Read More

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http://dx.doi.org/10.1007/s11356-019-04406-9DOI Listing
February 2019
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Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents.

Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Depatment of Genetics, Maharshi Dayanand University, Rohtak-124001, Haryana. India.

Background: Staphylococus epidermidis coagulase negative and gram positive streptococci have emerge as major nosocomial pathogens associated with infection of implanted medical devices and dandruff in human scalp. S. epidermidis filamenting temperature-sensitive mutant Z (FtsZ) gene encoded FtsZ protein that assembles at future bacterial cell division site that form Z-ring structure. Read More

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http://dx.doi.org/10.2174/1573406415666190206233448DOI Listing
February 2019
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In vivo evaluation and Alzheimer's disease treatment outcome of siRNA loaded dual targeting drug delivery system.

Curr Pharm Biotechnol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127. China.

To deliver drugs to treat Alzheimer's disease (AD), nanoparticles should firstly penetrate through blood brain barrier, and then target neurons. Recently, we developed an Apo A-I and NL4 dual modified nanoparticle (ANNP) to deliver beta-amyloid converting enzyme 1 (BACE1) siRNA. Although promising in vitro results were obtained, the in vivo performance was not clear. Read More

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http://dx.doi.org/10.2174/1389201020666190204141046DOI Listing
February 2019
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Prevention, monitoring and treatment of cardiovascular adverse events in myeloma patients receiving carfilzomib A Consensus Paper by the European Myeloma Network and the Italian Society of Arterial Hypertension.

J Intern Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine I, Hematology, Oncology& Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

The novel proteasome inhibitor carfilzomib alone or in combination with other agents is already one of the standard therapies in relapsed and/or refractory multiple myeloma (MM) patients and produces impressive response rates in newly diagnosed MM as well. However, carfilzomib-related cardiovascular adverse events (CVAEs) - including hypertension (all grades: 12.2%; grade ≥3: 4. Read More

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http://dx.doi.org/10.1111/joim.12882DOI Listing
February 2019
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The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System.

Front Neurosci 2019 22;13:15. Epub 2019 Jan 22.

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

The homeostasis of iron is of fundamental importance in the central nervous system (CNS) to ensure biological processes such as oxygen transport, mitochondrial respiration or myelin synthesis. Dyshomeostasis and accumulation of iron can be observed during aging and both are shared characteristics of several neurodegenerative diseases. Iron-mediated generation of reactive oxygen species (ROS) may lead to protein aggregation and cellular toxicity. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00015
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http://dx.doi.org/10.3389/fnins.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350163PMC
January 2019
3 Reads

Microbes Producing L-Asparaginase free of Glutaminase and Urease isolated from Extreme Locations of Antarctic Soil and Moss.

Sci Rep 2019 Feb 5;9(1):1423. Epub 2019 Feb 5.

Industrial Bioprocess and Bioprospecting Laboratory (IBBL), Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana State, 502285, India.

L-Asparaginase (L-asparagine aminohydrolase, E.C. 3. Read More

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http://www.nature.com/articles/s41598-018-38094-1
Publisher Site
http://dx.doi.org/10.1038/s41598-018-38094-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363723PMC
February 2019
2 Reads

N-nitrosodimethylamine (NDMA) induced apoptosis dependent on Fas/FasL complex in human leukocytes.

Hum Exp Toxicol 2019 Feb 6:960327119828198. Epub 2019 Feb 6.

1 Department of Immunology, Medical University of Białystok, Białystok, Poland.

Objective:: To investigate the mechanism of apoptosis dependent on the Fas/FasL (Fas ligand) complex in the presence of N-nitrosodimethylamine (NDMA) in human leukocytes.

Methods:: Polymorphonuclear neutrophils (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated form whole blood by density centrifugation. The concentration of NDMA was assessed by cellular toxicity assay. Read More

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http://dx.doi.org/10.1177/0960327119828198DOI Listing
February 2019
2 Reads

Imipenem toxicity in male reproductive organs as a result of inflammatory microenvironment and oxidative stress in germinal cells.

Toxicology 2019 Feb 2;416:44-53. Epub 2019 Feb 2.

Laboratory LR11ES45, Research Group Biotechnology and Pathology, Higher Institute of Biotechnology, International School of Engineers, Sfax, Tunisia.

Imipenem is a beta-Lactam antibiotic characterized by a broad spectrum of activity. It is prescribed to treat severe infections. Our goal is to investigate toxicity induced in male rat reproductive systems following exposure to this drug (15, 50 or 100 mg/kg) compared to gentamicin (50 mg/kg) treatment. Read More

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http://dx.doi.org/10.1016/j.tox.2019.02.001DOI Listing
February 2019
1 Read
3.621 Impact Factor