34,423 results match your criteria Toxicity Lead

Oxidation process of lead sulfide nanoparticle in the atmosphere or natural water and influence on toxicity toward Chlorella vulgaris.

J Hazard Mater 2021 May 8;417:126016. Epub 2021 May 8.

School of Resources and Civil Engineering, Northeastern University, Shenyang 110819, China. Electronic address:

Lead sulfide nanoparticle (nano-PbS) released into environment can cause hazards to human or ecosystem. Nano-PbS potentially undergoes oxidation in the environment, but oxidation mechanism is not understood yet. Herein, oxidation kinetics and products of nano-PbS by ozone (O), hydrogen peroxide (HO) and hydroxyl radical (HO·) in the atmosphere or natural water were investigated. Read More

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The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review.

Int Immunopharmacol 2021 May 11;96:107741. Epub 2021 May 11.

Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan. Iran. Electronic address:

Purpose: Radiation therapy is one of the main cancer treatment modalities applied in 50-70% of cancer patients. Despite the many advantages of this treatment, such as non-invasiveness, organ-preservation, and spatiotemporal flexibility in tumor targeting, it can lead to complications in irradiated healthy cells/tissues. In this regard, the use of radio-protective agents can alleviate radiation-induced complications. Read More

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Mechanisms and disease consequences of nonalcoholic fatty liver disease.

Cell 2021 May;184(10):2537-2564

Departments of Internal Medicine and Cellular & Molecular Physiology, Yale Diabetes Research Center, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. Here we provide an in-depth discussion of the underlying pathogenetic mechanisms that lead to progressive liver injury, including the metabolic origins of NAFLD, the effect of NAFLD on hepatic glucose and lipid metabolism, bile acid toxicity, macrophage dysfunction, and hepatic stellate cell activation, and consider the role of genetic, epigenetic, and environmental factors that promote fibrosis progression and risk of hepatocellular carcinoma in NASH. Read More

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Prospective bioremediation of toxic heavy metals in water by surfactant exopolysaccharide of Ochrobactrum pseudintermedium using cost-effective substrate.

Int Microbiol 2021 May 13. Epub 2021 May 13.

Department of Chemical Technology, Rajabazar Science College, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata, 700009, India.

Globally, the underlying peril of cumulative toxicity of heavy metals in water bodies contaminated by industrial effluents is a matter of great concern to the environmentalists. Heavy metals like lead, cadmium, and nickel are particularly liable for this. Such toxic water is not only hazardous to human health but also harmful to aquatic animals. Read More

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A 90-Day Oral Toxicity of Hydroethanolic Root Extract of in Wistar Rats.

J Toxicol 2021 20;2021:5570206. Epub 2021 Apr 20.

Laboratory of Physiology and Pharmacology, Faculty of Sciences, University of Lome, Lome, Togo.

Background: Herbal medication is a worldwide and ancient practice, mostly in developing countries, where a large part of the population is involved in this practice. Hence, studies must be conducted to evaluate their safety and efficiency to avoid or prevent toxicological risks due to their usage. In Togo, is a medicinal plant belonging to Apocynaceae family, used as an aphrodisiac or to heal some ailments including malaria, sickle cell anemia, hypertension, pain, and asthma. Read More

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Radiation Increases Bioavailability of Lisinopril, a Mitigator of Radiation-Induced Toxicities.

Front Pharmacol 2021 27;12:646076. Epub 2021 Apr 27.

Institute for Health and Equity, Division of Biostatistics, Medical College of WI, Milwaukee, WI, United States.

There are no FDA-approved drugs to mitigate the delayed effects of radiation exposure that may occur after a radiological attack or nuclear accident. To date, angiotensin-converting enzyme inhibitors are one of the most successful candidates for mitigation of hematopoietic, lung, kidney, and brain injuries in rodent models and may mitigate delayed radiation injuries after radiotherapy. Rat models of partial body irradiation sparing part of one hind leg (leg-out PBI) have been developed to simultaneously expose multiple organs to high doses of ionizing radiation and avoid lethal hematological toxicity to study the late effects of radiation. Read More

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Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy.

J Immunother Cancer 2021 May;9(5)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

COVID-19, the syndrome caused by the infection with SARS-CoV-2 coronavirus, is characterized, in its severe form, by interstitial diffuse pneumonitis and acute respiratory distress syndrome (ARDS). ARDS and systemic manifestations of COVID-19 are mainly due to an exaggerated immune response triggered by the viral infection. Cytokine release syndrome (CRS), an inflammatory syndrome characterized by elevated levels of circulating cytokines, and endothelial dysfunction are systemic manifestations of COVID-19. Read More

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Gastrointestinal Toxicity of Pelvic Radiotherapy: Are We Letting Women Down?

Clin Oncol (R Coll Radiol) 2021 May 10. Epub 2021 May 10.

Department of Gastroenterology, United Lincolnshire NHS Trust, Lincoln County Hospital, Lincoln, UK; The Biomedical Research Centre, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK. Electronic address:

For all cancers there are four areas of importance: prevention, early diagnosis, optimising therapy and living with and beyond. For women diagnosed with gynaecological cancers, progress in these first three areas has been immense. However, living with and beyond has largely been ignored as a significant issue. Read More

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Metal contamination and toxicity of soils and river sediments from the world's largest platinum mining area.

Environ Pollut 2021 May 3;286:117284. Epub 2021 May 3.

Department of Aquatic Ecology and Centre for Water and Environmental Research, University of Duisburg-Essen, Universitätsstr. 5, 45141, Essen, Germany. Electronic address:

Mining activities in the world's largest platinum mining area in South Africa have resulted in environmental contamination with Pt (e.g., the Hex River's vicinity). Read More

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Molecular scaffolds from mother nature as possible lead compounds in drug design and discovery against coronaviruses: A landscape analysis of published literature and molecular docking studies.

Microb Pathog 2021 May 10:104933. Epub 2021 May 10.

Department of Chemistry, Islamic University of Science and Technology, Awanti Pora, 192122, Jammu and Kashmir, India.

The recent outbreak of viral infection and its transmission has highlighted the importance of its slowdown for the safeguard of public health, globally. The identification of novel drugs and efficient therapies against these infectious viruses is need of the hour. The eruption of COVID-19 is caused by a novel acute respiratory syndrome virus SARS-CoV-2 which has taken the whole world by storm as it has transformed into a global pandemic. Read More

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A review on the Potential Mechanism of Lead Poisoning to the growth and development of ovarian follicle.

Toxicology 2021 May 10:152810. Epub 2021 May 10.

Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. Electronic address:

With the rapid development of economic globalization and industrialization, lead (Pb), one of the most important heavy metals, has been used widely since antiquity for several purposes. In fact, its impact on the health of animals and humans is a significant public health risk all the time. Pb could be accumulated in the body for a long time, causing irreversible damage to the health of animals and humans, including hostile reproductive health. Read More

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Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.

Arch Virol 2021 May 13. Epub 2021 May 13.

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, Novosibirsk, Russia, 630090.

A series of compounds containing a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment were evaluated for their antiviral activity against influenza A virus strain A/Puerto Rico/8/34 (H1N1) in vitro. Read More

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Dialkylamines Driven Two-Step Recovery of NiO/ITO Substrates for High-Reproducibility Recycling of Perovskite Solar Cells.

J Phys Chem Lett 2021 May 13:4735-4741. Epub 2021 May 13.

Department of Materials Science and Engineering, Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG), Southern University of Science and Technology, No. 1088, Xueyuan Road, Shenzhen, 518055, China.

Because of the toxicity of water-soluble lead, the recycling of organic-inorganic lead-halides perovskite solar cells (PSCs) has attracted increasing attention. Here, we report a highly reliable two-step process to recycle cost-dominated indium-tin-oxide (ITO) substrates coated with NiO and regenerate their based PSCs by function of dialkylamines. The champion recycled PSC can achieve 20% in conversion-efficiency, higher than 17. Read More

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Aquatic toxicity of particulate matter emitted by five electroplating processes in two marine microalgae species.

Toxicol Rep 2021 16;8:880-887. Epub 2021 Apr 16.

N.I. Vavilov All-Russian Institute of Plant Genetic Resources, Saint-Petersburg, 190000, Russia.

Electroplating is a widely used group of industrial processes that make a metal coating on a solid substrate. Our previous research studied the concentrations, characteristics, and chemical composition of nano- and microparticles emitted during different electroplating processes. The objective of this study was to evaluate the environmental toxicity of particulate matter obtained from five different electrochemical processes. Read More

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Discovery of pyridoindole derivatives as potential inhibitors for phosphodiesterase 5A: and studies.

Nat Prod Res 2021 May 13:1-10. Epub 2021 May 13.

Department of Pharmaceutical Quality Assurance, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

The aim of this work was to synthesise derivatives from identified plant based pyridoindole lead scaffold, and to assess phosphodiesterase 5A inhibitory potential by and . Pyridoindole derivatives were synthesised by using six-stage reactor. screening was carried out by grip-based docking methodology. Read More

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Metal-Fungus interaction: Review on cellular processes underlying heavy metal detoxification and synthesis of metal nanoparticles.

Chemosphere 2021 Jul 15;274:129976. Epub 2021 Feb 15.

Academy of Scientific and Innovative Research, CSIR-Institute of Minerals and Materials Technology, Bhubaneswar, 751013, India; Environment & Sustainability Department, CSIR-Institute of Minerals and Materials Technology, Bhubaneswar, 751013, India. Electronic address:

The most adverse outcome of increasing industrialization is contamination of the ecosystem with heavy metals. Toxic heavy metals possess a deleterious effect on all forms of biota; however, they affect the microbial system directly. These heavy metals form complexes with the microbial system by forming covalent and ionic bonds and affecting them at the cellular level and biochemical and molecular levels, ultimately leading to mutation affecting the microbial population. Read More

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Ethyl acetate fraction of () attenuates lead acetate induced testicular toxicity in male Wistar rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Benjamin S. Carson (Snr.) School of Medicine, Babcock University, Ilishan-Remo, Ogun State, Nigeria.

Objectives: The use of in folklore medicine for the management of reproductive disorders has been poorly reported. We sought to investigate the protective potential of the ethyl acetate fraction of stem bark extract (EFSC) on lead acetate-induced (LA) testicular toxicity in male rats.

Methods: Animals during a 28 days treatment received dimethyl sulfoxide (DMSO, 0. Read More

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Pegaspargase in Practice: Minimizing Toxicity, Maximizing Benefit.

Curr Hematol Malig Rep 2021 May 12. Epub 2021 May 12.

Department of Medicine, Division of Hematology and Oncology, University of Virginia School of Medicine, 1215 Lee Street, Charlottesville, VA, 22903, USA.

Purpose Of Review: The incorporation of pegaspargase in chemotherapy regimens has significantly improved the prognosis of ALL in adults. However, pegaspargase use poses many challenges due to its unique toxicity profile. Here, we review pegaspargase's most clinically significant toxicities, and provide guidance for their prevention and management in order to avoid unnecessary drug discontinuation and achieve maximum clinical benefit. Read More

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Ferroptosis in infection, inflammation, and immunity.

J Exp Med 2021 Jun 12;218(6). Epub 2021 May 12.

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, The Third Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. Read More

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Adipotropic effects of heavy metals and their potential role in obesity.

Fac Rev 2021 26;10:32. Epub 2021 Mar 26.

IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Epidemiological studies demonstrated an association between heavy metal exposure and the incidence of obesity and metabolic syndrome. However, the particular effects of metal toxicity on adipose tissue functioning are unclear. Therefore, recent findings of direct influence of heavy metals (mercury, cadmium, and lead) and metalloid (arsenic) on adipose tissue physiology are discussed while considering existing gaps and contradictions. Read More

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Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity.

Brain Commun 2021 26;3(2):fcab053. Epub 2021 Mar 26.

Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London WC1E 6BT, UK.

Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in models of amyloid beta 42 toxicity, genes involved in the unfolded protein response and metabolic processes are upregulated in brain. Read More

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Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future.

Curr Dev Nutr 2021 May 25;5(5):nzab018. Epub 2021 Feb 25.

Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC, USA.

The risk of vitamin D insufficiency in humans is a global problem that requires improving ways to increase vitamin D intake. Supplements are a primary means for increasing vitamin D intake, but without a clear consensus on what constitutes vitamin D sufficiency, there is toxicity risk with taking supplements. Chickens have been used in many vitamin-D-related research studies, especially studies involving vitamin D supplementation. Read More

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Magnetic resonance imaging-guided stereotactic body radiotherapy for prostate cancer (mirage): a phase iii randomized trial.

BMC Cancer 2021 May 11;21(1):538. Epub 2021 May 11.

Department of Radiation Oncology, University of California Los Angeles, 200 Medical Plaza Driveway, Suite # B265, Medical Plaza Driveway, Los Angeles, CA, 90095, USA.

Background: Stereotactic body radiotherapy (SBRT) is becoming increasingly used in treating localized prostate cancer (PCa), with evidence showing similar toxicity and efficacy profiles when compared with longer courses of definitive radiation. Magnetic resonance imaging (MRI)-guided radiotherapy has multiple potential advantages over standard computed tomography (CT)-guided radiotherapy, including enhanced prostate visualization (abrogating the need for fiducials and MRI fusion), enhanced identification of the urethra, the ability to track the prostate in real-time, and the capacity to perform online adaptive planning. However, it is unknown whether these potential advantages translate into improved outcomes. Read More

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Comparison between FOLFIRINOX and gemcitabine plus nab-paclitaxel including sequential treatment for metastatic pancreatic cancer: a propensity score matching approach.

BMC Cancer 2021 May 11;21(1):537. Epub 2021 May 11.

Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Background: FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GnP) have been recommended as the first-line chemotherapy for metastatic pancreatic cancer (mPC). However, the evidence is lacking comparing not only two regimens, but also sequential treatment (FFX-GnP vs. GnP-FFX). Read More

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Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter?

Environ Pollut 2021 Apr 29;286:117249. Epub 2021 Apr 29.

Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China.

The relationship between heavy metal(loid)s exposure and oxidative stress damage is a matter of research interest. Our study aimed to investigate the distribution patterns of the nine heavy metal(loid)s in blood of pregnant women, including four toxic heavy metal(loid)s [arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg)] and five typical heavy metal(loid)s [manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn), and selenium (Se)] in blood. Blood samples of 348 women were collected and their concentrations in the serum (sr) and blood cells (bc) were measured, as well as serum heme oxygenase-1 (HO-1) (an oxidative stress marker). Read More

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Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.

Brian A Baldo

Arch Toxicol 2021 May 11. Epub 2021 May 11.

Molecular Immunology Unit, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, Sydney, NSW, 2070, Australia.

Opioid-induced respiratory depression is potentially life-threatening and often regarded as the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia and hypercapnia. Respiratory depression is mediated by opioid μ receptors expressed on respiratory neurons in the CNS. Read More

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Antifouling paint particles in soils: toxic impact that goes beyond the aquatic environment.

Ecotoxicology 2021 May 10. Epub 2021 May 10.

Laboratório de Microcontaminantes Orgânicos e Ecotoxicologia Aquática-Instituto de Oceanografia, Universidade Federal do Rio Grande (FURG), Av. Itália, Km 8, Carreiros, Rio Grande, RS, 96203-900, Brazil.

Antifouling paint particles (APPs) originate from vessel maintenance and cleaning activities and their potentially toxic components are found at high concentrations in nearby soils, yet no studies have investigated their toxicity to soil organisms. We investigated the effects of exposure to soils containing APPs on the mortality, biomass, and reproductive performance of the earthworm Eisenia andrei. Earthworms were exposed to contaminated soil from a boatyard and non-contaminated soils treated with different concentrations of APPs (0. Read More

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Metals toxicity and its correlation with the gene expression in Alzheimer's disease.

Mol Biol Rep 2021 May 10. Epub 2021 May 10.

Geriatric Mental Health Department, KGMU, Lucknow, India.

Alzheimer's disease is a common neurodegenerative disease in the elderly population and a leading cause of dementia. Genetics and environmental risk factors were considered to play a major role in the onset of the disease. This study aimed to examine the correlation between different metals levels and the gene expression in Alzheimer's patients with age-matched control subjects. Read More

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Isoliensinine: A Natural Compound with "Drug-Like" Potential.

Front Pharmacol 2021 22;12:630385. Epub 2021 Apr 22.

Department of Pharmacy, Phase I Clinical, Trial Centre, Changsha Central Hospital Affiliated to University of South China, School of Pharmacy, University of South China, Changsha, China.

Isoliensinine, a bisbenzylisoquinoline alkaloid isolated from Gaertn, exerts a variety of beneficial effects, such as antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV effects, and ameliorates T2DM with hyperlipidemia and Alzheimer's disease. In this article, the recent literature on isoliensinine, including its pharmacology, pharmacokinetics, and synthesis and extraction, is summarized. Moreover, possible future prospects and research directions are also discussed. Read More

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[Management of patients developing acute gastro-intestinal graft-versus-host-disease: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2021 May 6. Epub 2021 May 6.

Université de Lille, CHU de Lille, Inserm U1286, Infinite, 59000 Lille, France.

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic cell transplantation (allo-HCT) with a frequency range of 30% to 50%. GVH is the leading cause of non-relapse-related deaths and a cause early mortality. Gastro-intestinal (GI) GVH results in digestive manifestations that involve the small intestine and the colon. Read More

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