Front Mol Biosci 2021 23;8:752072. Epub 2021 Nov 23.
School of Public Health, Qingdao University, Qingdao, China.
Isoniazid (INH), an effective first-line drug for tuberculosis treatment, has been reported to be associated with hepatotoxicity for decades, but the underlying mechanisms are poorly understood. -acetyltransferase 2 (NAT2) is a Phase II enzyme that specifically catalyzes the acetylation of INH, and NAT2 expression/activity play pivotal roles in INH metabolism, drug efficacy, and toxicity. In this study, we systematically investigated the regulatory roles of microRNA (miRNA) in expression and INH-induced liver injury via a series of , , and analyses. Read More