11,518 results match your criteria Toxicity Iron


Effect of iron overload from multi walled carbon nanotubes on neutrophil-like differentiated HL-60 cells.

Sci Rep 2019 Feb 18;9(1):2224. Epub 2019 Feb 18.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa, 761-0395, Japan.

Multi walled carbon nanotubes (MWCNTs) are one of the most intensively explored nanomaterials because of their unique physical and chemical properties. Due to the widespread use of MWCNTs, it is important to investigate their effects on human health. The precise mechanism of MWCNT toxicity has not been fully elucidated. Read More

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http://dx.doi.org/10.1038/s41598-019-38598-4DOI Listing
February 2019

Metatranscriptomics of the bacterial community in response to atmospheric deposition in the Western North Pacific Ocean.

Mar Genomics 2019 Feb 15. Epub 2019 Feb 15.

Division of Life Science, Hong Kong University of Science and Technology, Hong Kong Special Administrative Region. Electronic address:

Atmospheric deposition represents a major vector of both macro- and micro-nutrients to the oligotrophic open oceans, potentially imposing a profound impact on the functioning of the microbial community. Whereas bacterial responses to atmospheric deposition are being studied at the community level, corresponding functional changes are essentially unknown. Here we conducted a microcosm experiment coupled with metatranscriptomic analyses to elucidate taxonomic and functional profiles of the bacterial community in response to East Asian aerosols in the Western North Pacific Ocean (WNPO). Read More

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http://dx.doi.org/10.1016/j.margen.2019.01.008DOI Listing
February 2019

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro.

J Neuroinflammation 2019 Feb 18;16(1):41. Epub 2019 Feb 18.

Neuroscience Graduate Program, Uniformed Services University of the Health Sciences, Room C2099, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.

Background: Excessive iron contributes to oxidative stress after central nervous system injury. NADPH oxidase (NOX) enzymes are upregulated in microglia after pro-inflammatory activation and contribute to oxidative stress. The relationship between iron, microglia, NOX, and oxidative stress is currently unclear. Read More

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http://dx.doi.org/10.1186/s12974-019-1430-7DOI Listing
February 2019

Effect of superparamagnetic nanoparticles coated with various electric charges on α-synuclein and ÎČ-amyloid proteins fibrillation process.

Int J Nanomedicine 2019 23;14:799-808. Epub 2019 Jan 23.

National Institute of Genetic Engineering and Biotechnology, Tehran, Iran,

Background: Most of nanoparticles are nontoxic and have high absorption capability. Therefore, nanoparticles binding can effectively restrain fibrillation of ÎČ-amyloid and α-synuclein proteins and eventually prevent the toxicity of pathogenesis peptide of Alzheimer. Super paramagnetic iron oxide nanoparticles (SPIONs) contain iron oxide core which can be connected to a special part through magnetic coating. Read More

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http://dx.doi.org/10.2147/IJN.S190354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361412PMC
January 2019

Responses of wheat (Triticum aestivum) plants grown in a Cd contaminated soil to the application of iron oxide nanoparticles.

Ecotoxicol Environ Saf 2019 Feb 13;173:156-164. Epub 2019 Feb 13.

Soil, and Groundwater-Management, Institute for Soil Engineering, Water and Wastewater Management, University of Wuppertal, Pauluskirchstraße 7, Wuppertal, Germany; Department of Environment and Energy, Sejong University, Seoul 05006, Republic of Korea.

The present study demonstrated the possible impacts of iron oxide nanoparticles (Fe NPs) on the alleviation of toxic effects of cadmium (Cd) in wheat and enhance its growth, yield, and Fe biofortification. A pot experiment was conducted in historically Cd-contaminated soil using five levels of Fe NPs (0, 5, 10, 15, and 20 ppm) by soil and foliar application methods. The plants were harvested after 125 days of growth while vegetative parameters, antioxidant capacity, electrolyte leakage (EL) in leaves as well as Cd, and Fe concentrations in wheat grains, roots, and shoots were measured. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.118DOI Listing
February 2019
2.762 Impact Factor

Treatment of vinegar industry wastewater by electrocoagulation with monopolar aluminum and iron electrodes and toxicity evaluation.

Water Sci Technol 2018 Dec;78(12):2542-2552

Open Education Faculty/Department of Health Programs, Anadolu University, Eskisehir, Turkey E-mail:

We present electrocoagulation (EC) treatment results of vinegar industry wastewater (VIW) using parallel plate aluminum and iron electrodes, and analyze the toxicity of the treatment processes. Due to the chemical complexity of vinegar production wastewater, several parameters are expected to alter the treatment efficiency. Particularly, current density, initial pH, NaSO as support electrolyte, polyaluminum chloride (PAC) and kerafloc are investigated for their effects on chemical oxygen demand (COD) removal. Read More

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http://dx.doi.org/10.2166/wst.2019.013DOI Listing
December 2018

Toxic but tasty - Temporal dynamics and network architecture of heme-responsive two-component signalling in Corynebacterium glutamicum.

Mol Microbiol 2019 Feb 15. Epub 2019 Feb 15.

Institute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum JĂŒlich, 52425, JĂŒlich, Germany.

Heme is an essential cofactor and alternative iron source for almost all bacterial species but may cause severe toxicity upon elevated levels and consequently, regulatory mechanisms coordinating heme homeostasis represent an important fitness trait. A remarkable scenario is found in several corynebacterial species, e.g. Read More

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http://dx.doi.org/10.1111/mmi.14226DOI Listing
February 2019

Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells.

Toxicol Res 2019 Jan 15;35(1):83-91. Epub 2018 Jan 15.

Department of Veterinary Toxicology, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Korea.

Nanoparticles (NPs) have been recognized as both useful tools and potentially toxic materials in various industrial and medicinal fields. Previously, we found that zinc oxide (ZnO) NPs that are neurotoxic to human dopaminergic neuroblastoma SH-SY5Y cells are mediated by lipoxygenase (LOX), not cyclooxygenase-2 (COX-2). Here, we examined whether human bone marrow-derived mesenchymal stem cells (MSCs), which are different from neuroblastoma cells, might exhibit COX-2- and/or LOX-dependent cytotoxicity of ZnO NPs. Read More

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http://dx.doi.org/10.5487/TR.2019.35.1.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354944PMC
January 2019

Biodurability and release of metals during the dissolution of chrysotile, crocidolite and fibrous erionite.

Environ Res 2019 Apr 8;171:550-557. Epub 2019 Jan 8.

Department of Engineering "Enzo Ferrari", The University of Modena and Reggio Emilia, Via Vivarelli 10, I-41125 Modena, Italy.

Background: The mechanisms by which mineral fibers induce adverse effects in vivo are still not well understood. The mechanisms of fiber dissolution in the lungs and subsequent release of metals in the extracellular/intracellular environment must be taken into account.

Aim: For the first time, the kinetics of release of metals during the acellular in vitro dissolution of chrysotile, crocidolite and fibrous erionite were determined. Read More

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http://dx.doi.org/10.1016/j.envres.2019.01.011DOI Listing

Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications.

Colloids Surf B Biointerfaces 2019 Feb 3;177:253-259. Epub 2019 Feb 3.

BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de AndalucĂ­a-Universidad de MĂĄlaga), MĂĄlaga, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 29590 MĂĄlaga, Spain. Electronic address:

Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic agents for magnetic resonance imaging, with improved specificity and safety. Indeed, during the last decade the number of studies published in this field has grown exponentially. However, the clinical translation achieved so far has been very limited. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.051DOI Listing
February 2019

Review article: iron disturbances in chronic liver diseases other than haemochromatosis - pathogenic, prognostic, and therapeutic implications.

Authors:
Albert J Czaja

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Background: Disturbances in iron regulation have been described in diverse chronic liver diseases other than hereditary haemochromatosis, and iron toxicity may worsen liver injury and outcome.

Aims: To describe manifestations and consequences of iron dysregulation in chronic liver diseases apart from hereditary haemochromatosis and to encourage investigations that clarify pathogenic mechanisms, define risk thresholds for iron toxicity, and direct management METHODS: English abstracts were identified in PubMed by multiple search terms. Full length articles were selected for review, and secondary and tertiary bibliographies were developed. Read More

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http://dx.doi.org/10.1111/apt.15173DOI Listing
February 2019
1 Read

Computational, experimental details, and biological raw data accompanying the publication: "The synthesis and characterization of a nanomagnetite with potent antibacterial activity and low mammalian toxicity".

Data Brief 2018 Dec 11;21:2518-2521. Epub 2018 Sep 11.

Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4.

This data file includes experimental details on how to make uncoated iron oxide nanoparticles using a green electrochemical method. It provides the raw data on the antibacterial activity of one of these formulations, and the full computational data and methodology used to generate that data, of several different magnetite clusters of specific spin multiplicities for 4, 5, 7 and 9 iron atom magnetite clusters. This data will assist other researchers wishing to replicate or expand on these results for the investigation and use of nanomagnetite for antibacterial applications. Read More

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http://dx.doi.org/10.1016/j.dib.2018.08.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288310PMC
December 2018
1 Read

Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.

Expert Rev Neurother 2019 Feb 13. Epub 2019 Feb 13.

a Department of Molecular Pharmacology , Albert Einstein College of Medicine , Bronx , NY , USA.

Introduction: Iron (Fe) and manganese (Mn) are essential nutrients for humans. They act as cofactors for a variety of enzymes. In the central nervous system (CNS), these two metals are involved in diverse neurological activities. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
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http://dx.doi.org/10.1080/14737175.2019.1581608DOI Listing
February 2019
2 Reads

Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting onto Iron Oxide Nanoparticles.

Macromol Rapid Commun 2019 Feb 12:e1800911. Epub 2019 Feb 12.

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

Brush polymers are highly functional polymeric materials combining the properties of different polymer classes and have found numerous applications, for example, in nanomedicine. Here, the synthesis of functional phosphonate-ester-bearing brush polymers based on poly(2-oxazine)s is reported through a combination of cationic ring-opening polymerization (CROP) of 2-ethyl-2-oxazine and reversible addition-fragmentation chain transfer (RAFT) polymerization. In this way, a small library of well-defined (Đ ≀ 1. Read More

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http://dx.doi.org/10.1002/marc.201800911DOI Listing
February 2019
1 Read

AmpI functions as an iron exporter to alleviate ÎČ-lactam-mediated ROS stress in .

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan

is an organism with a remarkable capacity for drug resistance with several antibiotic resistance determinants in its genome. genome codes for L1 and L2 responsible for intrinsic ÎČ-lactam resistance. The Smlt3721 gene (denoted ), located downstream of the gene, encodes an inner membrane protein. Read More

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http://dx.doi.org/10.1128/AAC.02467-18DOI Listing
February 2019
1 Read

Genetic, reproductive and oxidative damage in mice triggered by co-exposure of nanoparticles: From a hypothetical scenario to a real concern.

Sci Total Environ 2019 Apr 7;660:1264-1273. Epub 2019 Jan 7.

Department of Pharmaceutical Sciences, Federal University of Santa Catarina, FlorianĂłpolis, SC 88040-900, Brazil. Electronic address:

Humans are potentially exposed to multiple nanoparticles kinds through nanotechnology-based consumer products. There is insufficient data on the in vivo toxicity of nanotechnology products, as well as no data on the possible toxicity, including genotoxicity and reproductive toxicity of co-exposure to different kind of nanoparticles. In this work, solid lipid nanoparticles (SLNs) and superparamagnetic iron oxide nanoparticles (SPIONs) were selected for evaluation of a hypothetical condition of in vivo co-exposure. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.036DOI Listing
April 2019
1 Read

Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo.

ChemistryOpen 2019 Feb 23;8(2):155-165. Epub 2019 Jan 23.

Department of Tissue Culture and Stem Cells Institute of Experimental Medicine, Czech Academy of Sciences Vídeƈskå 1083 Prague Czech Republic.

Manganese-zinc ferrite nanoparticles were synthesized by using a hydrothermal treatment, coated with silica, and then tested as efficient cellular labels for cell tracking, using magnetic resonance imaging (MRI) in vivo. A toxicity study was performed on rat mesenchymal stem cells and C6 glioblastoma cells. Adverse effects on viability and cell proliferation were observed at the highest concentration (0. Read More

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http://dx.doi.org/10.1002/open.201800261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356160PMC
February 2019
1 Read

Biochar effect associated with compost and iron to promote Pb and As soil stabilization and Salix viminalis L. growth.

Chemosphere 2019 Jan 31;222:810-822. Epub 2019 Jan 31.

University of Orléans, INRA USC1328, LBLGC EA1207, Orléans, France. Electronic address:

Soil pollution by metal(loid)s is one of the most significant problems in Europe. To remediate and potentially rehabilitate these contaminated sites, phytoremediation procedures are being put into place, often using amendments to help offset the extreme conditions of such soils. The aim of this study was to define the best amendment to use on the field. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.188DOI Listing
January 2019
1 Read

"Magnetic Particle Imaging (MPI) in Neurosurgery".

World Neurosurg 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Stanford, California, 94305, U.S.A.

Magnetic particle imaging (MPI) is a novel radiation-free tomographic imaging method that provides a background-free, signal attenuation-free, direct quantification of the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIONs) with high temporal resolution (milliseconds), high spatial resolution (< 1 mm), and extreme sensitivity (ÎŒmol). The technique is based on non-linear magnetization of the SPIONs when exposed to an oscillating magnetic field. MPI was first described in 2001. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.180DOI Listing
February 2019
1 Read

Curcumin and (-)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells Against Iron Toxicity and Erastin-Induced Ferroptosis.

Pharmaceuticals (Basel) 2019 Feb 6;12(1). Epub 2019 Feb 6.

Department of Nutritional Sciences, School of Life Course Sciences, King's College London. Franklin-Wilkins-Building, 150 Stamford Street, London, SE1 9NH, UK.

Ferroptosis is a form of programmed cell death that is characterized by lipid peroxidation and is inducible by iron and the accumulation of reactive oxygen species (ROS). It is triggered by erastin but inhibited by antioxidants such as -tocopherol, -carotene, polyphenols, and iron chelators such as deferoxamine (DFO), nitrilotriacetic acid (NTA), and ethylenediaminetetraacetic acid (EDTA). This study investigated the protective effects of two polyphenols, curcumin and (-)- epigallocatechin-3-gallate (EGCG), against iron loading and erastin-mediated ferroptosis in MIN6 cells. Read More

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http://dx.doi.org/10.3390/ph12010026DOI Listing
February 2019
2 Reads

Critical Review: Biogeochemical Networking of Iron, Is It Important in Constructed Wetlands for Wastewater Treatment?

Environ Sci Technol 2019 Feb 8. Epub 2019 Feb 8.

Iron is present in all types of wastewater, however besides acid mine drainage, where it is a major constituent of concern, it is usually neglected in other types of wastewaters. However, in all constructed wetlands iron plays important role in removal of organics, phosphorus and does have an impact on transformation of nitrogen and sulphur. The biogeochemistry of iron is well understood in natural wetlands but knowledge about iron impact on microbiological and chemical transformations during wastewater treatment in constructed wetlands is very limited. Read More

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http://dx.doi.org/10.1021/acs.est.8b07136DOI Listing
February 2019
1 Read

Sub-acute oral exposure of zinc oxide nanoparticles causes alteration in iron homeostasis through acute phase response: A protective effect by surface modification.

J Trace Elem Med Biol 2019 Mar 14;52:270-287. Epub 2019 Jan 14.

Biochemistry Laboratory, Animal Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials. Following oral exposure, these NPs can accumulate in various organs and induce the toxicity due to their physiochemical characteristics. In present study to reduce the toxicity, surface engineered ZnO NPs (c-ZnO NPs) were in-situ synthesized by using polyacrylamide grafted guar gum (PAm-g-GG) polymer in alkaline media. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.008DOI Listing
March 2019
2 Reads
2.491 Impact Factor

Cell Viability in Normal Fibroblasts and Liver Cancer Cells After Treatment with Iron (III), Nickel (II), and their Mixture.

J Vet Res 2018 Dec 31;62(4):535-542. Epub 2018 Dec 31.

Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957 Olsztyn, Poland.

Introduction: Nickel and iron are very commonly occurring metals. Nickel is used in industry, but nowadays it is also used in medical biomaterials. Iron is an element necessary for cell metabolism and is used in diet supplements and biomaterials, whence it may be released along with nickel. Read More

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https://content.sciendo.com/view/journals/jvetres/62/4/artic
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http://dx.doi.org/10.2478/jvetres-2018-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364161PMC
December 2018
4 Reads

Long-term live cells observation of internalized fluorescent Fe@C nanoparticles in constant magnetic field.

J Nanobiotechnology 2019 Feb 6;17(1):27. Epub 2019 Feb 6.

Faculté de Médecine, Université François Rabelais, 37032, Tours, France.

Background: Theranostics application of superparamagnetic nanoparticles based on magnetite and maghemite is impeded by their toxicity. The use of additional protective shells significantly reduced the magnetic properties of the nanoparticles. Therefore, iron carbides and pure iron nanoparticles coated with multiple layers of onion-like carbon sheath seem to be optimal for biomedicine. Read More

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http://dx.doi.org/10.1186/s12951-019-0463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364403PMC
February 2019
1 Read

The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System.

Front Neurosci 2019 22;13:15. Epub 2019 Jan 22.

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

The homeostasis of iron is of fundamental importance in the central nervous system (CNS) to ensure biological processes such as oxygen transport, mitochondrial respiration or myelin synthesis. Dyshomeostasis and accumulation of iron can be observed during aging and both are shared characteristics of several neurodegenerative diseases. Iron-mediated generation of reactive oxygen species (ROS) may lead to protein aggregation and cellular toxicity. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00015
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http://dx.doi.org/10.3389/fnins.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350163PMC
January 2019
3 Reads

New insights on Cr(VI) retention by ferrihydrite in the presence of Fe(II).

Chemosphere 2019 Jan 30;222:511-516. Epub 2019 Jan 30.

Beijing Key Laboratory of Water Resources and Environmental Engineering, School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing 100083, PR China.

Hexavalent chromium [Cr(VI)] contamination poses a significant environment hazard due to its high toxicity, solubility, and mobility. Fe(II) is often found to co-exist with iron oxide minerals (IOMs) that are naturally occurring in soil and groundwater. However, the mechanism by which Cr(VI) is retained by IOMs in the presence of Fe(II) remains unclear. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.160DOI Listing
January 2019

Functional analysis of iron-sulfur cluster biogenesis (SUF pathway) from Plasmodium vivax clinical isolates.

Exp Parasitol 2019 Feb 2;198:53-62. Epub 2019 Feb 2.

Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Rajasthan, India. Electronic address:

Iron-sulfur (Fe-S) clusters are critical metallo-cofactors required for cell function. Assembly of these cofactors is a carefully controlled process in cells to avoid toxicity from free iron and sulfide. In Plasmodium, two pathways for these Fe-S cluster biogenesis have been reported; ISC pathway in the mitochondria and SUF pathway functional in the apicoplast. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.01.015DOI Listing
February 2019
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The Effect of Electrode Topography on the Magnetic Properties and MRI Application of Electrochemically-Deposited, Synthesized, Cobalt-Substituted Hydroxyapatite.

Nanomaterials (Basel) 2019 Feb 3;9(2). Epub 2019 Feb 3.

Graduate Institute of Oral Science, Chung Shan Medical University, Taichung 40201, Taiwan.

Magnetic nanoparticles are used to enhance the image contrast of magnetic resonance imaging (MRI). However, the development of magnetic nanoparticles with a low dose/high image contrast and non-toxicity is currently a major challenge. In this study, cobalt-substituted hydroxyapatite nanoparticles deposited on titanium (Ti-CoHA) and cobalt-substituted hydroxyapatite nanoparticles deposited on titanium dioxide nanotubes (TNT-CoHA) were synthesized by the electrochemical deposition method. Read More

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http://dx.doi.org/10.3390/nano9020200DOI Listing
February 2019

The Effect of Daily Iron Supplementation with 60 mg Ferrous Sulfate for 12 Weeks on Non-Transferrin Bound Iron Concentrations in Women with a High Prevalence of Hemoglobinopathies.

J Clin Med 2019 Feb 3;8(2). Epub 2019 Feb 3.

Food, Nutrition and Health, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

There is a lack of evidence for the safety of untargeted daily iron supplementation in women, especially in countries such as Cambodia, where both anemia and hemoglobinopathies are common. Our aim was to assess serum non-transferrin bound iron (NTBI), a toxic biochemical that accumulates in blood when too much iron is absorbed, in Cambodian women who received daily iron supplements in accordance with the 2016 global World Health Organization (WHO) guidelines. We used fasting venous blood samples that were collected in a 2015 supplementation trial among predominantly anemic Cambodian women (18⁻45 years). Read More

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http://dx.doi.org/10.3390/jcm8020180DOI Listing
February 2019

In situ bioremediation of hexavalent chromium in presence of iron by dried sludge bacteria exposed to high chromium concentration.

Ecotoxicol Environ Saf 2019 Feb 1;172:281-289. Epub 2019 Feb 1.

Department of Chemical Engineering, University of Pretoria, Pretoria 0002, South Africa.

Stability of chromium in the ferrochrome slag dumps and leachate are affected by pH, redox potential and the presence of other metallic species in the slag. It is desirable to keep chromium in slag dumps in the trivalent [Cr(III)] state because trivalent chromium is 1000 times less toxic to living organisms than the hexavalent form [Cr(VI)]. Due to the low toxicity and low mobility of Cr(III), it is recommended to convert Cr(VI) to Cr(III) wherever possible to protect the health of living organisms. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.094DOI Listing
February 2019

Preliminary results of the Phase 1 Lip-Re I clinical trial: biodistribution and dosimetry assessments in hepatocellular carcinoma patients treated with Re-SSS Lipiodol radioembolization.

Eur J Nucl Med Mol Imaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Nuclear Medicine, Cancer Institute EugĂšne Marquis, Avenue de la Bataille Flandres-Dunkerque, CS 44229, 35042, Rennes, cedex, France.

Purpose: This study sought to provide preliminary results on the biodistribution and dosimetry following intra-arterial liver injection of Re-SSS Lipiodol on hepatocellular carcinoma patients included in the Phase I Lip-Re 1 study.

Methods: Results of the first six patients included are reported. Analysis of the Re-SSS Lipiodol biodistribution was based on planar scintigraphic and tomoscintigraphic (SPECT) studies performed at 1, 6, 24, 48, and 72 h post-administration. Read More

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http://dx.doi.org/10.1007/s00259-019-04277-9DOI Listing
February 2019
1 Read

Inhibition of naphthalene leaching from municipal carbonaceous waste by a magnetic organophilic clay.

J Hazard Mater 2019 Jan 26;368:578-583. Epub 2019 Jan 26.

Department of Earth and Atmospheric Sciences, University of Alberta, Edmonton, Alberta T6G 2E3, Canada.

Municipal solid waste conversion into biofuels via gasification is one of the latest technologies to divert waste from landfills. The byproduct of the process is a carbonaceous material, which is often tainted with polycyclic aromatic hydrocarbons (PAH) such as naphthalene that can leach into the environment and have toxic effects on aquatic organisms. In this paper, we present a novel method to address the issue of leachable naphthalene in a carbonaceous waste produced from a gasification process, using a magnetic sorbent. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.01.088DOI Listing
January 2019
1 Read

Brain and bone cancer targeting by a ferrofluid composed of superparamagnetic iron-oxide/silica/carbon nanoparticles (earthicles).

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Advanced Materials and Nanobiotechnology Laboratory, Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA 92618-1908, USA; Advanced Materials and Nanobiotechnology Laboratory, Department of Bioengineering, University of Illinois, Chicago, IL 60607-7052, USA. Electronic address:

Despite the advances in molecularly targeted therapies, delivery across the blood-brain barrier (BBB) and the targeting of brain tumors remains a challenge. Like brain, bone is a common site of metastasis and requires therapies capable of discerning the tumor from its healthy cellular milieu. To tackle these challenges, we made a variation on the previously proposed concept of the earthicle and fabricated an aqueous, surfactant-free ferrofluid containing superparamagnetic iron oxide nanoparticles (SPIONs) coated with silicate mesolayers and carbon shells, having 13 nm in size on average. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193008
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http://dx.doi.org/10.1016/j.actbio.2019.01.064DOI Listing
February 2019
5 Reads

Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin.

J Nanobiotechnology 2019 Feb 2;17(1):22. Epub 2019 Feb 2.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland.

Background: Human plasma gelsolin (pGSN) is a multifunctional actin-binding protein involved in a variety of biological processes, including neutralization of pro-inflammatory molecules such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and modulation of host inflammatory response. It was found that PBP10, a synthetic rhodamine B-conjugated peptide, based on the phosphoinositide-binding site of pGSN, exerts bactericidal activity against Gram-positive and Gram-negative bacteria, interacts specifically with LPS and LTA, and limits microbial-induced inflammatory effects. The therapeutic efficiency of PBP10 when immobilized on the surface of iron oxide-based magnetic nanoparticles was not evaluated, to date. Read More

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http://dx.doi.org/10.1186/s12951-019-0455-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359803PMC
February 2019
2 Reads
4.078 Impact Factor

Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile.

Neurotoxicol Teratol 2019 Jan 30;72:29-38. Epub 2019 Jan 30.

Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar. Electronic address:

Objectives: Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity to iron and reduce toxicity. Although its efficacy was established in one small cohort clinical trial, its potential adverse effect was not adequately addressed. Read More

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http://dx.doi.org/10.1016/j.ntt.2019.01.004DOI Listing
January 2019
1 Read

α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload.

Int J Mol Sci 2019 Jan 31;20(3). Epub 2019 Jan 31.

Department of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.

Iron toxicity is associated with organ injury and has been reported in various clinical conditions, such as hemochromatosis, thalassemia major, and myelodysplastic syndromes. Therefore, iron chelation therapy represents a pivotal therapy for these patients during their lifetime. The aim of the present study was to assess the iron chelating properties of α-lipoic acid (ALA) and how such an effect impacts on iron overload mediated toxicity. Read More

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http://dx.doi.org/10.3390/ijms20030609DOI Listing
January 2019
2 Reads
2.862 Impact Factor

Toxicity evaluation of monodisperse PEGylated magnetic nanoparticles for nanomedicine.

Nanotoxicology 2019 Feb 1:1-17. Epub 2019 Feb 1.

a Institute of Macromolecular Chemistry, Czech Academy of Sciences , Prague , Czech Republic.

Innovative nanotechnology aims to develop particles that are small, monodisperse, smart, and do not cause unintentional side effects. Uniform magnetic FeO nanoparticles (12 nm in size) were prepared by thermal decomposition of iron(III) oleate. To make them colloidally stable and dispersible in water and cell culture medium, they were modified with phosphonic acid- (PA) and hydroxamic acid (HA)-terminated poly(ethylene glycol) yielding PA-PEG@FeO and HA-PEG@FeO nanoparticles; conventional γ-FeO particles were prepared as a control. Read More

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https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1
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http://dx.doi.org/10.1080/17435390.2018.1555624DOI Listing
February 2019
3 Reads

Surface characterization and chemical speciation of adsorbed iron(iii) on oxidized carbon nanoparticles.

Environ Sci Process Impacts 2019 Jan 31. Epub 2019 Jan 31.

School of Natural Sciences, Sierra Nevada Research Institute, University of California, Merced, California, USA.

Carbonaceous nanomaterials represent a significant portion of ultra-fine airborne particulate matter, and iron is the most abundant transition metal in air particles. Owing to their high surface area and atmospheric oxidation, carbon nanoparticles (CNP) are enriched with surface carbonyl functional groups and act as a host for metals and small molecules. Using a synthetic model, concentration-dependent changes in the chemical speciation of iron adsorbed on oxidized carbon surfaces were investigated by a combination of X-ray and electron microscopic and spectroscopic methods. Read More

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http://dx.doi.org/10.1039/c8em00545aDOI Listing
January 2019
1 Read

Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.

Chem Res Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232-0146 , United States.

Human cytochrome P450 (P450) family 4 enzymes are involved in the metabolism of fatty acids and the bioactivation of carcinogenic arylamines and toxic natural products, e.g., 4-ipomeanol. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.8b00353DOI Listing
February 2019

Fenton treatment of sanitary landfill leachate: optimization of operational parameters, characterization of sludge and toxicology.

Environ Technol 2019 Jan 29:1-33. Epub 2019 Jan 29.

a Programa de PĂłs Graduação em CiĂȘncia e Tecnologia Ambiental, Departamento de Engenharia SanitĂĄria e Ambiental , Universidade Estadual da ParaĂ­ba , Campina Grande , PB , Brazil.

This investigation aimed to refine the operational parameters of the Fenton process, to compare Fenton-treated and non-treated leachate with respect to physicochemical variables and toxicity towards Daphnia magna, and to characterize the sludge. The optimal conditions for the Fenton treatment involved the use of a reagent containing 12 g Fe L, HO/Fe molar ratio of 9 and pH 2.0, with oxidation, flocculation and sedimentation times of 30, 10 and 15  min, respectively. Read More

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http://dx.doi.org/10.1080/09593330.2019.1576773DOI Listing
January 2019
1 Read

Tolerance of Iron-Deficient and -Toxic Soil Conditions in Rice.

Plants (Basel) 2019 Jan 28;8(2). Epub 2019 Jan 28.

Rice Breeding Platform, International Rice Research Institute (IRRI), Los Baños, Laguna 4031, Philippines.

Iron (Fe) deficiency and toxicity are the most widely prevalent soil-related micronutrient disorders in rice ( L.). Progress in rice cultivars with improved tolerance has been hampered by a poor understanding of Fe availability in the soil, the transportation mechanism, and associated genetic factors for the tolerance of Fe toxicity soil (FTS) or Fe deficiency soil (FDS) conditions. Read More

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http://dx.doi.org/10.3390/plants8020031DOI Listing
January 2019

New mixed amino acids complexes of iron(III) and zinc(II) with isonitrosoacetophenone: Synthesis, spectral characterization, DFT study and anticancer activity.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jan 17;213:235-248. Epub 2019 Jan 17.

Laboratoire d'Hydrométallurgie et Chimie Inorganique Moléculaire, Faculté de Chimie, USTHB, BP 32 El Alia, Bab Ezzouar, Algiers, Algeria.

New mixed Fe(III) and Zn(II) complexes with isonitrosoacetophenone (HINAP) and l-amino acids (such as l-histidine, l-phenylalanine and l-proline) have been synthesized and characterized by elemental analyses, UV-Vis, IR and ESR spectroscopy and thermal analyses. The values of molar conductance of the complexes in DMSO solution at 10 M concentration indicate their non-electrolyte nature. IR spectroscopy has revealed the coordination of deprotonated ligands to metal through nitrogen and oxygen atoms in an NO arrangement. Read More

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http://dx.doi.org/10.1016/j.saa.2019.01.042DOI Listing
January 2019
1 Read

Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator Transport Polymorphism on the Human Red Blood Cell Mean Corpuscular Volume (MCV).

Int J Environ Res Public Health 2019 Jan 27;16(3). Epub 2019 Jan 27.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Research has shown that long-term exposure to lead harms the hematological system. The homeostatic iron regulator (hemochromatosis) mutation, which has been shown to affect iron absorption and iron overload, is hypothesized to be related to lead intoxication in vulnerable individuals. The aim of our study was to investigate whether the genotype modifies the blood lead levels that affect the distributions of serum iron and other red blood cell indices. Read More

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http://dx.doi.org/10.3390/ijerph16030354DOI Listing
January 2019
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Self-Propelled and Targeted Drug Delivery of Poly(aspartic acid)/Iron-Zinc Microrocket in the Stomach.

ACS Nano 2019 Jan 30. Epub 2019 Jan 30.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science , Shandong Normal University , Jinan 250014 , P. R. China.

For many medical treatments, particularly cancer, it is necessary to develop a biocompatible microscale device that can carry a sufficient amount of a drug and deliver it to target sites. While chemically powered micromotors have been applied in live animal therapy, many of them are difficult to biodegrade in vivo, which might cause toxicity and side effects. Here, we report on a microdevice that consists of a poly(aspartic acid) (PASP) microtube, a thin Fe intermediate layer, and a core of Zn. Read More

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http://dx.doi.org/10.1021/acsnano.8b06773DOI Listing
January 2019
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Influence of algal blooms decay on arsenic dynamics at the sediment-water interface of a shallow lake.

Chemosphere 2019 Mar 11;219:1014-1023. Epub 2018 Dec 11.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Algal blooms decay affects the mobility, bioavailability, and toxicity of arsenic (As) in aquatic environments. The decaying process alters aquatic redox conditions and also introduces ample organic matter, conditions favorable for microbial reduction to simulate As release and As species transformation. This study investigated the role of algae (Microcystis aeruginosa (MA)) blooms decay on the dynamics of labile As and elements associated with its release, such as iron (Fe), manganese (Mn) and sulfide (S), at the sediment-water surface (SWI) of a shallow lake (Lake Taihu) in China, applying mesocosm incubation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.080DOI Listing
March 2019
3 Reads

Effects and control of metal nutrients and species on Microcystis aeruginosa growth and bloom.

Water Environ Res 2019 Jan;91(1):21-31

School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, China.

The effects and control of typical metal nutrients, copper, iron, and zinc, on the growth and bloom of Microcystis aeruginosa were investigated with a series of flask-shaking tests. The optimal concentrations of copper, iron, and zinc for algal growth were 0.001, 3-12, and 0. Read More

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http://dx.doi.org/10.2175/106143017X15131012188303DOI Listing
January 2019
1 Read

Oxidative Stress of Carbon Nanotubes on Proteins Is Mediated by Metals Originating from the Catalyst Remains.

ACS Nano 2019 Feb 6. Epub 2019 Feb 6.

Nanomaterials Research Institute , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Ibaraki 305-8565 , Japan.

Nanomaterials introduced into biological systems are immediately coated by proteins in vivo. They induce oxidative stress on adsorbed proteins and hence alter the protein structures, which determines the fate pathways and biological impacts of nanomaterials. Carbon nanotubes (CNTs) have been suggested to cause protein oxidation. Read More

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http://dx.doi.org/10.1021/acsnano.8b07936DOI Listing
February 2019
1 Read

A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy.

Biomaterials 2019 Mar 18;197:284-293. Epub 2019 Jan 18.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; University of Science and Technology of China, Hefei, 230026, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, PR China.

Despite multifunctional nanoparticles using for photothermal therapy can efficiently kill cancer cells, their further application is still hindered by the intrinsic high uptake in the reticuloendothelial system (RES) organs, causing the slow elimination from the body and potential toxicity to the body. Therefore, it is ideal to develop multifunctional nanoparticles which process the ability to effectively accumulate in tumors, while the nanoparticles can be rapidly excreted from the body via renal clearance after effective treatment. Herein, we report the multifunctional nanoparticles (FeTNPs) based on the coordination interaction of phenolic group and metal iron, which are composed of ferric iron, tannic acid (TA) and poly (glutamic acid)-graft-methoxypoly (ethylene glycol) (PLG-g-mPEG). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.025DOI Listing
March 2019
2 Reads

Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin.

Front Mol Neurosci 2018 8;11:470. Epub 2019 Jan 8.

Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan.

Mitochondrial ferritin (FtMt) is an iron-transport protein with ferroxidase properties localized to mitochondria. Levels are generally low in all tissues, while increasing the expression of FtMt in neuronal-like cells has been shown to be protective. To determine whether FtMt has potential as a therapeutic approach, there remains the question of how much FtMt is protective. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331485PMC
January 2019

PmrC/EptA and CptA negatively affect outer membrane vesicle production in .

J Bacteriol 2019 01 22. Epub 2019 Jan 22.

Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

Outer membrane vesicles (OMVs) are naturally produced by Gram-negative bacteria by a bulging of the outer membrane (OM) and subsequent release in the environment. By serving as vehicles for various cargos, including proteins, nucleic acids and small metabolites, OMVs are central to interbacterial interactions and both symbiotic and pathogenic host bacterial interactions. However, despite their importance, the mechanism of OMV formation remains unclear. Read More

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http://dx.doi.org/10.1128/JB.00454-18DOI Listing
January 2019
2 Reads