11,596 results match your criteria Toxicity Iron


Plasma protein adsorption on FeO-PEG nanoparticles activates the complement system and induces an inflammatory response.

Int J Nanomedicine 2019 25;14:2055-2067. Epub 2019 Mar 25.

Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, México,

Background: Understanding of iron oxide nanoparticles (IONP) interaction with the body milieu is crucial to guarantee their efficiency and biocompatibility in nanomedicine. Polymer coating to IONP, with polyethyleneglycol (PEG) and polyvinylpyrrolidone (PVP), is an accepted strategy to prevent toxicity and excessive protein binding.

Aim: The aim of this study was to investigate the feature of IONP adsorption of complement proteins, their activation and consequent inflammatory response as a strategy to further elucidate their biocompatibility. Read More

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http://dx.doi.org/10.2147/IJN.S192214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438142PMC
March 2019
1 Read

PEGAylated graphene oxide/superparamagnetic nanocomposite as a high-efficienc loading nanocarrier for controlled delivery of methotrexate.

J Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, 81746-73441, Iran.

Polymer-coated nanocarriers play an important role in targeted drug delivery. The use of polymers such as polyethylene glycol increases stability, biocompatibility, and blood circulation time of the drug, and may consequently improve the success of drug delivery. In the present work, a simple approach has been reported for synthesizing polyethylene glycol bis amin (PEGA) functionalized graphene oxide/iron oxide nanocomposite as a remarkable unit for loading drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.006DOI Listing
April 2019
1 Read

Evaluation of the raw water quality: physicochemical and toxicological approaches.

Environ Geochem Health 2019 Apr 13. Epub 2019 Apr 13.

Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235 - s/n - Setor Universitário, Goiânia, Goiás, Brazil.

Environmental degradation has increased, mainly as a result of anthropogenic effects arising from population, industrial and agricultural growth. Water pollution is a problem that affects health, safety and welfare of the whole biota which shares the same environment. In Goiânia and metropolitan region, the main water body is the Meia Ponte River that is used for the abstraction of water, disposal of treated wastewater and effluents. Read More

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http://dx.doi.org/10.1007/s10653-019-00292-9DOI Listing
April 2019
2 Reads

A novel theranostic system of AS1411 aptamer-functionalized albumin nanoparticles loaded on iron oxide and gold nanoparticles for doxorubicin delivery.

Int J Pharm 2019 Apr 9. Epub 2019 Apr 9.

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Recently DNA aptamers have attracted remarkable attention as possible targeting ligands since selective targeting of cancer cells is a critical step in cancer diagnosis and therapy. Here, the development of AS1411 aptamer-functionalized albumin nanoparticles loaded on iron oxide and gold nanoparticles is reported for target delivery of the well-known anticancer drug of doxorubicin (Dox). Iron oxide nanoparticles (IONPs) and gold nanoparticles (GNPs) were prepared by ultrasound-assisted and controlled seeded growth synthetic methods, respectively. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.025DOI Listing
April 2019
2 Reads

Impacts of earthworm species on soil acidification, Al fractions, and base cation release in a subtropical soil from China.

Environ Sci Pollut Res Int 2019 Apr 10. Epub 2019 Apr 10.

College of Natural Resources and Environment, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou 510642, China.

Soil-exchangeable aluminum (Al) has toxic effects on living organisms in acidic soils. Earthworm presence and activity can alter soil pH, which has a significant influence on Al toxicity. However, the effects of earthworms on soil Al toxicity and fractions are still largely unknown. Read More

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http://dx.doi.org/10.1007/s11356-019-05055-8DOI Listing
April 2019
1 Read

Cadmium-induced oxidative stress, histopathology, and transcriptome changes in the hepatopancreas of freshwater crayfish (Procambarus clarkii).

Sci Total Environ 2019 May 14;666:944-955. Epub 2019 Feb 14.

State Key Lab of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

Cadmium (Cd) is a common contaminant in environment. Crayfish are considered suitable for indicating the impact of heavy metals on the environment. However, there is limited information on the mechanisms causing damage to the hepatopancreas of Procambarus clarkii exposed to Cd. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.159DOI Listing
May 2019
1 Read

Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia.

Cardiovasc Toxicol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA.

Ambient particulate matter (PM) is associated with increased mortality and morbidity, an effect influenced by the metal components of the PM. We characterized five sediment samples obtained near a tungsten-molybdenum ore-processing complex in Zakamensk, Russia for elemental composition and PM toxicity with regard to pulmonary, vascular, and neurological outcomes. Elemental and trace metals analysis of complete sediment and PM (the respirable fraction, < 10 µm mass mean aerodynamic diameter) were performed using inductively coupled plasma optical emission spectrometry (ICP-OES) and mass spectrometry (ICP-MS). Read More

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http://dx.doi.org/10.1007/s12012-019-09507-yDOI Listing
April 2019
1 Read

Antimony Removal from Water by a Chitosan-Iron(III)[ChiFer(III)] Biocomposite.

Polymers (Basel) 2019 Feb 18;11(2). Epub 2019 Feb 18.

Department of Chemical Engineering, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028 Barcelona, Spain.

The presence of antimony(III) in water represents a worldwide concern, mainly due to its high toxicity and carcinogenicity potential. It can be separated from water by the use of sustainable biopolymers such as chitosan or its derivatives. The present study applied chitosan modified with iron(III) beads to Sb(III) removal from aqueous solutions. Read More

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http://dx.doi.org/10.3390/polym11020351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419170PMC
February 2019
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Self-enhanced and efficient removal of arsenic from waste acid using magnetite as an in situ iron donator.

Water Res 2019 Mar 29;157:269-280. Epub 2019 Mar 29.

State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming, 650093, China.

High arsenic-containing waste acid from the heavy nonferrous metallurgical sector (Cu, Pb, Zn, Ni, Sn, etc.), one of the most dangerous arsenic hazardous wastes with extremely high arsenic concentrations, has presented enormous challenges to the environment and caused severe environmental pollution over the past few decades due to the lack of affordable and environmentally friendly disposal technologies. Here, we report a green process for the self-enhanced and efficient removal of arsenic from waste acid using magnetite as an in situ iron donator. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354193021
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http://dx.doi.org/10.1016/j.watres.2019.03.067DOI Listing
March 2019
4 Reads

Removing arsenic from water by coprecipitation with iron: Effect of arsenic and iron concentrations and adsorbent incorporation.

Chemosphere 2019 Mar 26;226:431-438. Epub 2019 Mar 26.

Faculty of Engineering, University of Technology Sydney (UTS), P.O. Box 123, Broadway, NSW, 2007, Australia. Electronic address:

Arsenic (As) contamination of drinking water is a major cause of As toxicity in many parts of the world. A study was conducted to evaluate As removal from water containing 100-700 μg/L of As and As to Fe concentration ratios of 1:5-1:1000 using the coprecipitation process with and without As/Fe adsorption onto granular activated carbon (GAC). Fe concentration required to reduce As concentrations in order to achieve the WHO standard level of 10 μg/L increased exponentially with the increase in initial As concentration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193058
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http://dx.doi.org/10.1016/j.chemosphere.2019.03.142DOI Listing
March 2019
2 Reads

The alleviation effect of iron on cadmium phytotoxicity in mangrove A. marina. Alleviation effect of iron on cadmium phytotoxicity in mangrove Avicennia marina (Forsk.) Vierh.

Chemosphere 2019 Mar 27;226:413-420. Epub 2019 Mar 27.

Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen, 361102, China.

Cd has high activity and bioavailability and is a poisonous element to plants. As a critical ecosysterm, mangroves are subjected to serious Cd pollution. In this research, the hypothesis was presented that improving Fe bioavailability would alleviate Cd phytotoxicity to Avicennia marina (Forsk. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.03.172DOI Listing

Iron Metabolism of the Skeletal Muscle and Neurodegeneration.

Front Neurosci 2019 15;13:165. Epub 2019 Mar 15.

Department of Biochemistry, Gdańsk University of Physical Education and Sport, Gdańsk, Poland.

Recent studies clearly indicate that the endocrine function of the skeletal muscle is essential for a long and healthy life. Regular exercise, which has been shown to stimulate the release of myokines, lowers the risk of many diseases, including Alzheimer's and Parkinson's disease, emphasizing the role of skeletal muscle in proper functioning of other tissues. In addition, exercise increases insulin sensitivity, which may also impact iron metabolism. Read More

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http://dx.doi.org/10.3389/fnins.2019.00165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436082PMC
March 2019
1 Read

Effects of chelating agents on heavy metals in Hepatitis C Virus (HCV) patients.

Math Biosci Eng 2019 02;16(3):1138-1149

Department of Biochemistry, Government College University Faisalabad (GCUF), Pakistan.

Heavy metals are released into the environment through both human and natural sources, may have a direct hepatic toxicity and are involved in chronic liver diseases. Modification in the regulation of heavy metals metabolism enhanced hepatitis c virus (HCV) replication which ultimately reduced outcomes of anti-viral therapy in chronic HCV patients. Chelation therapy with new drugs seems to eradicate HCV and may prevent liver complications. Read More

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http://dx.doi.org/10.3934/mbe.2019054DOI Listing
February 2019
1 Read
0.866 Impact Factor

Superoxide Dismutase and Pseudocatalase Increase Tolerance to Hg(II) in Thermus thermophilus HB27 by Maintaining the Reduced Bacillithiol Pool.

MBio 2019 04 2;10(2). Epub 2019 Apr 2.

Department of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, New Jersey, USA

Mercury (Hg) is a widely distributed, toxic heavy metal with no known cellular role. Mercury toxicity has been linked to the production of reactive oxygen species (ROS), but Hg does not directly perform redox chemistry with oxygen. How exposure to the ionic form, Hg(II), generates ROS is unknown. Read More

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http://dx.doi.org/10.1128/mBio.00183-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445937PMC

A pH-Sensitive Zwitterionic Iron Complex Probe with High Biocompatibility for Tumor-Specific MR Imaging.

Chemistry 2019 Apr 2. Epub 2019 Apr 2.

South China Normal University, CHINA.

Accurate diagnosis of tumor characteristics, including its location and boundary, are of immense value to subsequent therapy. Activatable magnetic resonance imaging (MRI) contrast agents that respond to tumor-specific microenvironment, such as the redox state, pH, and enzyme activity, enable better mapping of tumor tissue. However, the practical application of most reported activatable agents is hampered by problems including potential toxicity, inefficient elimination, and slow activation. Read More

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http://dx.doi.org/10.1002/chem.201901117DOI Listing
April 2019
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Biodistribution and targeting properties of iron oxide nanoparticles for treatments of cancer and iron anemia disease.

Nanotoxicology 2019 Apr 2:1-24. Epub 2019 Apr 2.

a Paris Sorbonne Université, Muséum National d'Histoire Naturelle, UMR CNRS, IRD, Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie, IMPMC , Paris , France.

IONP (iron oxide nanoparticles) commercialized for treatments of iron anemia or cancer diseases can be administered at doses exceeding 1 g per patient, indicating their bio-compatibility when they are prepared in the right conditions. Various parameters influence IONP biodistribution such as nanoparticle size, hydrophobicity/hydrophilicity, surface charge, core composition, coating properties, route of administration, quantity administered, and opsonization. IONP biodistribution trends include their capture by the reticuloendothelial system (RES), accumulation in liver and spleen, leading to nanoparticle degradation by macrophages and liver Kupffer cells, possibly followed by excretion in feces. Read More

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https://www.tandfonline.com/doi/full/10.1080/17435390.2019.1
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http://dx.doi.org/10.1080/17435390.2019.1572809DOI Listing
April 2019
3 Reads

Bioprospection of anti-inflammatory phytochemicals suggests rutaecarpine and quinine as promising 15-lipoxygenase inhibitors.

J Cell Biochem 2019 Apr 1. Epub 2019 Apr 1.

Computational Biology Laboratory, Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong, Meghalaya, India.

15-Lipoxygenase (15-LOX) belongs to the family of nonheme iron containing enzymes that catalyzes the peroxidation of polyunsaturated fatty acids (PUFAs) to generate eicosanoids that play an important role in signaling pathways. The role of 15-LOX has been demonstrated in atherosclerosis as well as other inflammatory diseases. In the present study, drug-like compounds were first screened from a set of anti-inflammatory phytochemicals based on Lipinski's rule of five (ROF) and in silico toxicity filters. Read More

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http://dx.doi.org/10.1002/jcb.28634DOI Listing
April 2019
2 Reads

Silver, Gold, and Iron Oxide Nanoparticles Alter miRNA Expression but Do Not Affect DNA Methylation in HepG2 Cells.

Materials (Basel) 2019 Mar 29;12(7). Epub 2019 Mar 29.

Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland.

The increasing use of nanoparticles (NPs) in various applications entails the need for reliable assessment of their potential toxicity for humans. Originally, studies concerning the toxicity of NPs focused on cytotoxic and genotoxic effects, but more recently, attention has been paid to epigenetic changes induced by nanoparticles. In the present research, we analysed the DNA methylation status of genes related to inflammation and apoptosis as well as the expression of miRNAs related to these processes in response to silver (AgNPs), gold (AuNPs), and superparamagnetic iron oxide nanoparticles (SPIONs) at low cytotoxic doses in HepG2 cells. Read More

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https://www.mdpi.com/1996-1944/12/7/1038
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http://dx.doi.org/10.3390/ma12071038DOI Listing
March 2019
5 Reads

Influence of welding fume metal composition on lung toxicity and tumor formation in experimental animal models.

J Occup Environ Hyg 2019 Apr 1:1-6. Epub 2019 Apr 1.

a Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia.

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http://dx.doi.org/10.1080/15459624.2019.1587172DOI Listing
April 2019
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A comparison of the effects of natural organic matter on sulfidated and nonsulfidated nanoscale zerovalent iron colloidal stability, toxicity, and reactivity to trichloroethylene.

Sci Total Environ 2019 Mar 23;671:254-261. Epub 2019 Mar 23.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Beijing 100083, PR China. Electronic address:

Sulfidated nanoscale zerovalent iron (S-NZVI) is a new remediation material with higher reactivity and greater selectivity for chlorinated organic contaminants such as trichloroethene (TCE) than NZVI. The properties of S-NZVI and the effects of groundwater constituents like natural organic matter (NOM) on its reactivity are less well-characterized than for NZVI. In this study, S-NZVI (Fe/S mole ratio = 15) was synthesized by sonicating NZVI in a NaS solution, yielding particles with greater surface charge, less aggregation, and higher reactivity with TCE compared to NZVI. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.343DOI Listing
March 2019
3 Reads

Multicopper oxidases: Biocatalysts in microbial pathogenesis and stress management.

Microbiol Res 2019 May 16;222:1-13. Epub 2019 Feb 16.

Department of Microbiology, Panjab University, Chandigarh, India. Electronic address:

The acquisition of metal ions such as iron, copper and manganese is essential for the survival of microorganisms as these are constituents of metalloproteins including enzymes, storage proteins, structural elements, transcription factors and antimicrobial factors in various biological processes. However, excess of these metal ions is associated with significant toxicity due to spontaneous redox cycling of ions and obstruction of normal metabolic pathways. To overcome this, microbes have developed a variety of metal regulatory systems allowing them to adapt to the changing biotic and abiotic environments. Read More

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http://dx.doi.org/10.1016/j.micres.2019.02.007DOI Listing
May 2019
1 Read

In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework.

Molecules 2019 Mar 28;24(7). Epub 2019 Mar 28.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.

A MIL series metal‒organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological assessment was performed using two different cell lines: human normal liver cells (HL-7702) and hepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT assay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. Read More

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http://dx.doi.org/10.3390/molecules24071211DOI Listing
March 2019
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Nickel toxicity in plants: reasons, toxic effects, tolerance mechanisms, and remediation possibilities-a review.

Environ Sci Pollut Res Int 2019 Mar 29. Epub 2019 Mar 29.

Department of Agronomy, University of Agriculture, Faisalabad, Pakistan.

Nickel (Ni) is a naturally occurring metal, but anthropogenic activities such as industrialization, use of fertilizers, chemicals, and sewage sludge have increased its concentration in the environment up to undesirable levels. Ni is considered to be essential for plant growth at low concentration; however, Ni pollution is increasing in the environment, and therefore, it is important to understand its functional roles and toxic effects on plants. This review emphasizes the environmental sources of Ni, its essentiality, effects, tolerance mechanisms, possible remediation approaches, and research direction that may help in interdisciplinary studies to assess the significance of Ni toxicity. Read More

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http://dx.doi.org/10.1007/s11356-019-04892-xDOI Listing
March 2019
2 Reads

The role of electron shuttle enhances Fe(III)-mediated reduction of Cr(VI) by Shewanella oneidensis MR-1.

World J Microbiol Biotechnol 2019 Mar 28;35(4):64. Epub 2019 Mar 28.

Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention, School of Resources and Environment, Anhui Agricultural University, Hefei, 230036, China.

Chromate is one of the hazardous toxic pollutants. Reduction of Cr(VI) to Cr(III) has shown to reduce the toxicity of chromate. This work examined the reduction of Cr(VI) using an anaerobic batch cultures of Shewanella oneidensis MR-1 containing Fe(III). Read More

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http://dx.doi.org/10.1007/s11274-019-2634-9DOI Listing
March 2019
1 Read

Oxidation mechanisms of amoxicillin and paracetamol in the photo-Fenton solar process.

Water Res 2019 Jun 6;156:232-240. Epub 2019 Mar 6.

Department of Environmental Technologies, Faculty of Marine and Environmental Sciences, University of Cádiz, Cadiz, Spain.

The present study shows the results of solar photo-Fenton oxidation of paracetamol (PCT) and amoxicillin (AMX). Fe(SO) was used as the source of iron and EDDS as the iron complexing agent, employing different doses of hydrogen peroxide. Two aqueous matrices, a synthetic wastewater and real wastewater from El Ejido WWTP effluent (Almeria) were used. Read More

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http://dx.doi.org/10.1016/j.watres.2019.02.055DOI Listing
June 2019
1 Read

Gallium- and Iron-Pyoverdine Coordination Compounds Investigated by X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy.

Inorg Chem 2019 Apr 28;58(8):4935-4944. Epub 2019 Mar 28.

Department of Science , Roma Tre University , Via della Vasca Navale 79 , 00146 Rome , Italy.

Iron is an essential nutrient for nearly all forms of life, although scarcely available due to its poor solubility in nature and complex formation in higher eukaryotes. Microorganisms have evolved a vast array of strategies to acquire iron, the most common being the production of high-affinity iron chelators, termed siderophores. The opportunistic bacterial pathogen Pseudomonas aeruginosa synthesizes and secretes two siderophores, pyoverdine (PVD) and pyochelin (PCH), characterized by very different structural and functional properties. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03574DOI Listing
April 2019
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Oxidation of high iron content electroplating sludge in supercritical water: stabilization of zinc and chromium.

Environ Sci Pollut Res Int 2019 Mar 27. Epub 2019 Mar 27.

School of Marine Sciences, Guangxi Key Laboratory on the Study of Coral Reefs in the South China Sea, Guangxi University, No. 100 East Daxue Road, Xixiangtang District, Nanning, 530004, Guangxi Autonomous Region, China.

The stabilization of heavy metals (zinc and chromium) and the degradation of organic pollutants during supercritical water (SCW) and supercritical water oxidation (SCWO) treatment of electroplating sludge (EPS) with a high iron content were studied. Experiments were performed in a batch reactor at temperatures in the range from 623.15 to 823. Read More

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http://dx.doi.org/10.1007/s11356-019-04897-6DOI Listing
March 2019
3 Reads
2.828 Impact Factor

Synthesis of TPEN variants to improve cancer cells selective killing capacity.

Bioorg Chem 2019 Mar 16;87:366-372. Epub 2019 Mar 16.

Department of Physiology and Biophysics, Weill Cornell Medicine - Qatar, Doha, Qatar. Electronic address:

TPEN is an amino chelator of transition metals that is effective at the cellular and whole organism levels. Although TPEN of often used as a selective zinc chelators, it has affinity for copper and iron and has been shown to chelate both biologically. We have previously shown that TPEN selectively kills colon cancer cells based on its ability to chelate copper, which is highly enriched in colon cancer cells. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.045DOI Listing
March 2019
2 Reads
2.152 Impact Factor

Surface defects reduce carbon nanotube toxicity in vitro.

Toxicol In Vitro 2019 Mar 22. Epub 2019 Mar 22.

Fraunhofer Institute for Toxicology and Experimental Medicine, Department of Preclinical Pharmacology and Toxicology, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany. Electronic address:

The cytotoxicity of two different types of Multi-walled Carbon Nanotubes (MWCNTs) in A549 lung epithelial cells and HepG2 hepatocytes was investigated. One MWCNT still contained iron that was used as a catalyst during production, while the other one had all iron removed in a post-production heat treatment resulting in significantly fewer surface defects. The WST-8 assay was applied to test cell viability. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.03.028DOI Listing
March 2019
1 Read

Intracellular iron availability modulates the requirement for Leishmania Iron Regulator 1 (LIR1) during macrophage infections.

Int J Parasitol 2019 Mar 22. Epub 2019 Mar 22.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA; Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA; Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

The Leishmania plasma membrane transporter Leishmania Iron Regulator 1 (LIR1) facilitates iron export and is required for parasite virulence. By modulating macrophage iron content, we investigated the host site where LIR1 regulates Leishmania amazonensis infectivity. In bone marrow-derived macrophages, LIR1 null mutants demonstrated a paradoxical increase in virulence during infections in heme-depleted media, while wild-type growth was inhibited under the same conditions. Read More

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http://dx.doi.org/10.1016/j.ijpara.2019.02.002DOI Listing
March 2019
1 Read

Rutin abrogates manganese-Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway.

J Trace Elem Med Biol 2019 May 24;53:8-15. Epub 2019 Jan 24.

Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Excess exposure to Manganese (Mn) promotes oxidative stress and neuro-inflammation. Rutin (RUT) has been found to exhibit both anti-oxidative stress and anti-inflammatory properties. This study aimed to investigate the effects of RUT on Mn accumulation, endogenous iron (Fe) depletion, oxidative stress, inflammation and nuclear factor kappa B (NF-κB) signaling pathways in the hippocampus and striatum of Mn - induced rats. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.014DOI Listing
May 2019
1 Read

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition.

Biochem Biophys Res Commun 2019 Mar 20. Epub 2019 Mar 20.

Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. Electronic address:

Invasive aspergillosis (IA) is a life-threatening disease impacting immunocompromised individuals. Standard treatments of IA, including polyenes and azoles, suffer from high toxicity and emerging resistance, leading to the need to develop new antifungal agents with novel mechanisms of action. Ergosterol biosynthesis is a classic target for antifungals, and squalene synthase (SQS) catalyzes the first committed step in ergosterol biosynthesis in Aspergillus spp. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.070DOI Listing
March 2019
1 Read
2.297 Impact Factor

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.

Eur Heart J 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, Heidelberg, Germany.

Aims: Whether and how iron affects the progression of atherosclerosis remains highly debated. Here, we investigate susceptibility to atherosclerosis in a mouse model (ApoE-/- FPNwt/C326S), which develops the disease in the context of elevated non-transferrin bound serum iron (NTBI).

Methods And Results: Compared with normo-ferremic ApoE-/- mice, atherosclerosis is profoundly aggravated in iron-loaded ApoE-/- FPNwt/C326S mice, suggesting a pro-atherogenic role for iron. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz112DOI Listing
March 2019
1 Read
15.203 Impact Factor

Effects of mine tailings exposure on early life stages of Atlantic cod.

Environ Toxicol Chem 2019 Mar 22. Epub 2019 Mar 22.

Akvaplan-niva, Fram Centre, Tromsø, Norway.

In Norway, mine tailings waste can be deposited by coastal submarine dispersal. Mine tailings slurry include fine particles <10 µm with elevated levels of metals (e.g. Read More

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http://dx.doi.org/10.1002/etc.4415DOI Listing
March 2019
1 Read

Green tea activity and iron overload induced molecular fibrogenesis of rat liver.

Saudi J Biol Sci 2019 Mar 18;26(3):531-540. Epub 2017 Aug 18.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Iron overload toxicity was shown to associate with chronic liver diseases which lead to hepatic fibrosis and subsequently the progression to cancer through oxidative stress and apoptotic pathways. Green tea potential activity as chelating, anti-oxidative, or anti-apoptotic mechanisms against metal toxicity was poorly clarified. Here, we are trying to evaluate the anti-oxidant and anti-apoptotic properties of green tea in the regulation of serum hepcidin levels, reduction in iron overloads, and improve of liver fibrosis in iron overloaded experimental rats. Read More

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http://dx.doi.org/10.1016/j.sjbs.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408694PMC
March 2019
1 Read

Removal of Hazardous Oxyanions from the Environment Using Metal-Oxide-Based Materials.

Materials (Basel) 2019 Mar 20;12(6). Epub 2019 Mar 20.

Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, PL-60965 Poznan, Poland.

Scientific development has increased the awareness of water pollutant forms and has reawakened the need for its effective purification. Oxyanions are created by a variety of redox-sensitive metals and metalloids. These species are harmful to living matter due to their toxicity, nondegradibility, and mobility in aquatic environments. Read More

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http://dx.doi.org/10.3390/ma12060927DOI Listing
March 2019
1 Read

Biological relevance of CuFeO nanoparticles: Antibacterial and anti-inflammatory activity, genotoxicity, DNA and protein interactions.

Mater Sci Eng C Mater Biol Appl 2019 Jun 26;99:264-274. Epub 2019 Jan 26.

Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. Electronic address:

Heterometal oxide nanoparticles of bioessential metals are shedding new light to nanoparticle-inspired bioapplications. Pairing bioreactive elements like copper and iron can affect the redox dynamic and biological profile of the nanomaterial. Given the complexity of physicochemical properties, biological activity and toxicity concerns, extensive exploration is demanded, especially when active and less active oxidation states participate as in case of cuprous-ferric delafossite CuFeO (copper(I)-iron(III)), a less widespread nanomaterial. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.112DOI Listing
June 2019
1 Read

Magnetically responsive hybrid nanoparticles for in vitro siRNA delivery to breast cancer cells.

Mater Sci Eng C Mater Biol Appl 2019 Jun 10;99:1182-1190. Epub 2019 Feb 10.

Department of Pharmaceutical Sciences, Federal University of Santa Catarina, 88040-900 Florianopolis, SC, Brazil. Electronic address:

Short interfering RNA (siRNA) showed to be a viable alternative to a better prognosis in cancer therapy. Nevertheless, the successful application of this strategy still depends on the development of nanocarriers for the safe delivery of siRNA into the diseased tissue, which mostly occurs by passive accumulation. When an external magnetic field is applied, magnetic nanoparticles biodistribution is partially modulated to favor accumulation in a target tissue. Read More

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http://dx.doi.org/10.1016/j.msec.2019.02.026DOI Listing
June 2019
2 Reads

Multi-Tissue Analysis of Exercise or Metformin on Doxorubicin-Induced Iron Dysregulation.

Am J Physiol Endocrinol Metab 2019 Mar 19. Epub 2019 Mar 19.

Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, Utah, United States.

Doxorubicin (DOX) is an effective chemotherapeutic treatment with lasting side effects in heart and skeletal muscle. DOX is known to bind with iron, contributing to oxidative damage resulting in cardiac and skeletal muscle toxicity. However, major cellular changes to iron regulation in response to DOX are poorly understood in liver, heart and skeletal muscle. Read More

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http://dx.doi.org/10.1152/ajpendo.00140.2018DOI Listing
March 2019
3 Reads

Heavy metals content in some non-alcoholic beverages (carbonated drinks, flavored yogurt drinks, and juice drinks) of the Egyptian markets.

Toxicol Rep 2019 25;6:210-214. Epub 2019 Feb 25.

Spectroscopy Department, Physics Division, National Research Centre, 33 El-Bohouth St., P.O. Box: 12622, Dokki, Cairo, Egypt.

Heavy metals are elements present in trace quantities in the environment and, in small concentrations, they play important roles for the living organisms yet it can cause toxicity if exceeded the recommended levels. Toxic metals contamination is an important environmental problem that was mainly manifested in the growing industrial cities where the levels in toxic metals exceeded the recommended levels leading to the increase of several health problems (that vary from memory disorder to carcinogenic diseases). The main sources of food contamination by toxic metals are the increase in petroleum fuels exhausts and the addition of fertilizers and metal-based pesticides during farming processes. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402291PMC
February 2019
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A review of small molecules and drug delivery applications using gold and iron nanoparticles.

Int J Nanomedicine 2019 11;14:1633-1657. Epub 2019 Mar 11.

Department of Chemical Engineering, 313 Snell Engineering Center, Northeastern University, Boston, MA, USA,

Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Read More

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http://dx.doi.org/10.2147/IJN.S184723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417854PMC
March 2019
3 Reads

Preparation and characterization of superparamagnetic iron oxide nanoparticles for magnetically guided drug delivery.

Int J Nanomedicine 2018 15;13(T-NANO 2014 Abstracts):43-46. Epub 2018 Mar 15.

Department of Chemistry, University of Delhi, Delhi, India.

Iron oxide nanoparticles have unique magnetic properties and therefore readily respond to applied magnetic fields. Moreover, their surfaces can be used to attach active molecules via various covalent or noncovalent interactions. Thus, they can be used as drug carriers for magnetically controlled delivery to specific biological sites of interest. Read More

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http://dx.doi.org/10.2147/IJN.S125002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419314PMC
March 2018
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Distribution and speciation of copper in rice (Oryza sativa L.) from mining-impacted paddy soil: Implications for copper uptake mechanisms.

Environ Int 2019 May 14;126:717-726. Epub 2019 Mar 14.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address:

Long term mining activities can cause significant metal pollution in the environment, thereby showing potential risk to the paddy field. Elucidating the interfacial processes of trace metals from contaminated paddy soil to rice within the rhizosphere can provide important information on metal biogeochemistry and food safety. The current study aims to explore the spatial distribution and molecular speciation of Cu from rhizosphere to rice plant in a mining-impacted paddy soil, and reveal the possible uptake mechanisms. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.045DOI Listing
May 2019
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Nanoparticles in foods? A multiscale physiopathological investigation of iron oxide nanoparticle effects on rats after an acute oral exposure: Trace element biodistribution and cognitive capacities.

Food Chem Toxicol 2019 May 14;127:173-181. Epub 2019 Mar 14.

Grenoble Alpes University, PROMETHEE Proteomic Platform, BEeSy, Grenoble, France; LBFA Inserm U1055, BEeSy, Grenoble, France; Institut de Biologie et Pathologie, CHU de Grenoble Alpes, France.

Iron Oxide Nanoparticles (IONPs) are used in several fields of application, mainly in the biomedical field for their magnetic properties and in food additive known as "E172" for their colour. In the present investigation, we focused on IONP effects on Wistar rat following acute oral exposure. We performed a multiscale physiopathological investigation in order to elucidate potential toxic effects linked to IONP ingestion, especially on cognitive capacities, trace element distribution, blood constituents, organ functions, organ structure and iron deposit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193011
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http://dx.doi.org/10.1016/j.fct.2019.03.006DOI Listing
May 2019
5 Reads

Assessment of potential dietary toxicity and arsenic accumulation in two contrasting rice genotypes: Effect of soil amendments.

Chemosphere 2019 Mar 2;225:104-114. Epub 2019 Mar 2.

Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

High concentration of arsenic (As) in rice is a serious problem worldwide. Pot experiments were conducted to assess the potential dietary toxicity of arsenic and effect of various soil amendments on arsenic accumulation in rice grains. Two basmati rice genotypes were used to conduct pot experiments using various levels of arsenic (10, 25, 50 and 100 mg kg soil). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.202DOI Listing
March 2019
2 Reads
3.340 Impact Factor

Bifunctional magnetopolymersomes of iron oxide nanoparticles and carboxymethylcellulose conjugated with doxorubicin for hyperthermo-chemotherapy of brain cancer cells.

Biomater Sci 2019 Mar 14. Epub 2019 Mar 14.

Center of Nanoscience, Nanotechnology and Innovation - CeNano2I, Federal University of Minas Gerais - UFMG, Av. Antônio Carlos, 6627 - Belo Horizonte/MG, Brazil.

Glioblastoma is the most aggressive primary brain cancer, which has no cure yet. Emerging nanotheranostic alternatives such as magnetic iron oxide nanoparticles (MIONs) have great potential as multimodal cancer therapy mediators. They can act as nanocarriers of anticancer drugs and generate localized heat when exposed to an alternating magnetic field (AMF), resulting in combined effects of chemotherapy and magnetic hyperthermia therapy. Read More

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http://dx.doi.org/10.1039/c8bm01528gDOI Listing
March 2019
2 Reads

Effective inhibition of copper-catalyzed production of hydroxyl radicals by deferiprone.

J Biol Inorg Chem 2019 Mar 13. Epub 2019 Mar 13.

Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus.

Copper ions can catalyze the production of free oxygen radicals (•OH and •OOH) similar to iron ions. The capacity to initiate oxidative damage is most commonly attributed to Cu-induced toxicity in copper-related diseases where there is an increase in copper levels and also when Cu homeostasis and regulation are disrupted. An antioxidant/chelator inhibiting Cu-induced oxidative damage could play a significant role in the treatment of such Cu-related diseases. Read More

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http://dx.doi.org/10.1007/s00775-019-01650-9DOI Listing
March 2019
2 Reads

Fluorescent organic nanoparticles (FONs) as convenient probes for metal ion detection in aqueous medium.

Analyst 2019 Apr;144(8):2480-2497

Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Recently, water contamination caused by metal ions has become one of the most serious problems as it has caused several deaths and socioeconomic problems around the world. Hence, the fast and accurate detection of metal ions in aqueous media has become the most important area of research; from time to time, new probes have been designed for this purpose. Among the previously reported sensors, probes based on fluorescent organic nanoparticles (FONs) have been gaining tremendous attention due to their ease of preparation/fabrication, synthetic diversity according to targeted metal ions, quick response, high selectivity toward different analytes at lower concentrations, tenable optical properties, and less toxicity. Read More

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http://dx.doi.org/10.1039/c8an01801dDOI Listing
April 2019
3 Reads