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Plant Physiol Biochem 2020 May 1;153:53-63. Epub 2020 May 1.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Botany, S.P. College Srinagar, Jammu and Kashmir, India. Electronic address:

It was aimed to examine the role of gibberellic acid (GA) induced production of hydrogen sulfide (HS) in alleviating boron toxicity (BT) in tomato plants. Two weeks after germination, a solution consisting of GA (100 mg L) was sprayed once a week for 14 days to the leaves of cv. "SC 2121" of tomato under BT stress (BT; 2. Read More

Bioorg Med Chem Lett 2020 Jul 27;30(13):127221. Epub 2020 Apr 27.

Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China. Electronic address:

A new Methylene blue-based 7-nitro-1,2,3-benzoxadiazole NIR fluorescent probe 3, 7-bis-dimethylamino-10-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-10H-phenothiazine (leuco-MB-NBD) was designed and synthesized. Leuco-MB-NBD showed high sensitivity and selectivity for HS as a fluorescent probe in CHOH-PBS (9:1, v/v, pH = 7.4) solution, this fluorescent assay showed a linear range of 0-50. Read More

J Biotechnol 2020 Jun 19;316:35-45. Epub 2020 Apr 19.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Botany, S.P. College Srinagar, Jammu and Kashmir, India. Electronic address:

The current research was aimed to observe the interactive role of silicon-generated hydrogen sulfide (HS) and nitric oxide (NO) on tolerance of pepper (Capsicum annum L.) plants to cadmium (Cd). Thus, the pepper plants were subjected to control (no Cd) or cadmium stress with and without Si supplementation. Read More

Anim Sci J 2020 Jan;91(1):e13349

College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.

Rumen fermentation can produce hydrogen sulfide (H S), and H S can be rapidly absorbed by the intestinal wall in nature. If excessive H S was produced in rumen, it might be toxic to ruminants. This article reviews the research progress of toxicity of H S, rumen H S production pathway and its influential factors to lay a foundation for further research and application of rumen H S-producing regulation in ruminant. Read More

Cells 2020 Mar 12;9(3). Epub 2020 Mar 12.

Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic.

Sulfate is present in foods, beverages, and drinking water. Its reduction and concentration in the gut depend on the intestinal microbiome activity, especially sulfate-reducing bacteria (SRB), which can be involved in inflammatory bowel disease (IBD). Assimilatory sulfate reduction (ASR) is present in all living organisms. Read More

J Inherit Metab Dis 2020 Mar 11. Epub 2020 Mar 11.

Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado, Aurora, Colorado.

Hydrogen sulfide, a signaling molecule formed mainly from cysteine, is catabolized by sulfide:quinone oxidoreductase (gene SQOR). Toxic hydrogen sulfide exposure inhibits complex IV. We describe children of two families with pathogenic variants in SQOR. Read More

Microb Biotechnol 2020 Jul 3;13(4):1026-1038. Epub 2020 Mar 3.

Center for Microbial Ecology and Technology (CMET), Ghent University, Coupure Links 653, Ghent, 9000, Belgium.

Biological CO sequestration through acetogenesis with H as electron donor is a promising technology to reduce greenhouse gas emissions. Today, a major issue is the presence of impurities such as hydrogen sulfide (H S) in CO containing gases, as they are known to inhibit acetogenesis in CO -based fermentations. However, exact values of toxicity and inhibition are not well-defined. Read More

Nat Commun 2020 03 2;11(1):1153. Epub 2020 Mar 2.

Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, F-38000, France.

Cyt1Aa is the one of four crystalline protoxins produced by mosquitocidal bacterium Bacillus thuringiensis israelensis (Bti) that has been shown to delay the evolution of insect resistance in the field. Limiting our understanding of Bti efficacy and the path to improved toxicity and spectrum has been ignorance of how Cyt1Aa crystallizes in vivo and of its mechanism of toxicity. Here, we use serial femtosecond crystallography to determine the Cyt1Aa protoxin structure from sub-micron-sized crystals produced in Bti. Read More

Int J Phytoremediation 2020 Mar 2:1-11. Epub 2020 Mar 2.

Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.

A laboratory experiment was performed to evaluate the potential role of HS on cadmium (Cd) toxicity in L. Seeds pretreated with 0.3, 0. Read More

Biomater Sci 2020 Mar;8(7):1981-1995

Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, PR China.

Improving the generation of reactive oxygen species (ROS) while consuming glutathione (GSH) is the main method for amplifying intracellular oxidative stress. However, in previous studies, it was normally necessary to combine two or more materials to achieve the effect of destroying the intracellular redox homeostasis. This made the preparation process relatively complicated. Read More

Antioxid Redox Signal 2020 Mar 13. Epub 2020 Mar 13.

Antibe Therapeutics, Inc., Toronto, Canada.

The covalent linking of nonsteroidal anti-inflammatory drugs to a hydrogen sulfide (HS)-releasing moiety has been shown to dramatically reduce gastrointestinal (GI) damage and bleeding, as well as increase anti-inflammatory and analgesic potency. We have tested the hypothesis that an HS-releasing derivative of ketoprofen (ATB-352) would exhibit enhanced efficacy without significant GI damage in a mouse model of allodynia/hyperalgesia. ATB-352 was significantly more potent and effective as an analgesic than ketoprofen and did not elicit GI damage. Read More

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Jan;38(1):1-6

Institute of Toxicology, Shandong University, Jinan 250012, China.

To investigate the antagonistic effect of diallyl sulfide (DAS) against peripheral nerve injury induced by n-hexane in rats. A total of 68 adult male Wistar rats were selected, among which 50 were randomly selected and divided into blank control group, DAS control group (100 mg/kg·bw) , n-hexane model group, low-dose DAS intervention group (50 mg/kg·bw) , and high-dose DAS intervention group (100 mg/kg·bw) . A rat model of peripheral nerve injury was established by n-hexane exposure, and the rats were treated with DAS at different doses. Read More

J Am Chem Soc 2020 Mar 25;142(9):4309-4316. Epub 2020 Feb 25.

Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.

The recent discovery of hydropersulfides (RSSH) in mammalian systems suggests their potential roles in cell signaling. However, the exploration of RSSH biological significance is challenging due to their instability under physiological conditions. Herein, we report the preparation, RSSH-releasing properties, and cytoprotective nature of alkylamine-substituted perthiocarbamates. Read More

Biomacromolecules 2020 Mar 13;21(3):1171-1178. Epub 2020 Feb 13.

Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United States.

Controlled release is an essential requirement for delivery of hydrogen sulfide (HS) because of its reactive nature, short half-life in biological fluids, and toxicity at high concentrations. In this context, HS delivery via hydrogels may be beneficial as they can deliver HS locally at the site of interest. Herein, we employed hydrogels based on aromatic peptide amphiphiles (APAs) with tunable mechanical properties to modulate the rates of HS release. Read More

J Photochem Photobiol B 2020 Mar 20;204:111799. Epub 2020 Jan 20.

Centre for Nano and Material Sciences, Jain Global Campus, Jain University, Bangalore 562112, India. Electronic address:

CdSe/CdS core shelled quantum dots (QDs) were prepared by colloidal synthesis using a binary ligand system and a non-coordinating, reusable solvent n-octadecane (nOD). Both the synthesis of CdSe and CdSe/CdS core shelled quantum dots were achieved by hot injection technique at much lower temperatures than reported earlier. The use of binary ligand facilitated enough nucleation and growth. Read More

Bioresour Technol 2020 Apr 23;302:122885. Epub 2020 Jan 23.

Laboratory of Environmental Technology, School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China. Electronic address:

Sulfide has attracted increasing attention due to its odor nuisance, toxicity and corrosion. Although variations in the nitrogen removal performance of anammox under sulfide stress have been reported previously, understanding the microorganisms at the molecular level is of greater significance. This study first deciphered the microbial community and functional gene response of anammox sludge to sulfide stress. Read More

Chem Pharm Bull (Tokyo) 2020 ;68(2):129-132

Department of Chemistry, Nagoya University.

Efficient methods for delivery of antisense DNA or small interfering RNA (siRNA) are highly needed. Cationic materials, which are conventionally used for anionic oligonucleotide delivery, have several drawbacks, including aggregate formation, cytotoxicity and a low endosome escape efficiency. In this report a bio-reactive mask (i. Read More

Ecotoxicol Environ Saf 2020 Mar 21;191:110215. Epub 2020 Jan 21.

College of Natural Resources and Environment, Northwest A&F University, Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry of Agriculture, Yangling, 712100, Shaanxi, China. Electronic address:

Information on the kinetic characteristics of soil enzymes under long-term arsenic (As) pollution in field soils is scarce. We investigated Michaelis-Menten kinetic properties of four soil enzymes including β-glucosidase (BG), acid phosphatase (ACP), alkaline phosphatase (ALP), and dehydrogenase (DHA) in field soils contaminated by As resulting from long-term realgar mining activity. The kinetic parameters, namely the maximum reaction velocity (V), enzyme-substrate affinity (K) and catalytic efficiency (V/K) were calculated. Read More

J Mater Chem B 2020 Feb;8(7):1422-1431

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

A small-molecule fluorescent probe offers unique advantages for the detection of hydrogen sulfide (H2S) and other reactive small molecules including high sensitivity, cell permeability and high spatiotemporal resolution. Generally, in order to obtain good cell permeability, fluorescent probes are liposoluble, which in turn leads to poor water solubility. Thus, it is regrettable that most of these fluorescent probes cannot be used in fully aqueous systems and hence, organic solvents are used, which may cause negative effects on living cells. Read More

J Hazard Mater 2020 04 9;388:122061. Epub 2020 Jan 9.

Department of Biology, Faculty of Science, Ege University, Bornova, 35100, Izmir, Turkey. Electronic address:

The role of hydrogen sulfide (HS)/nitric oxide (NO) in mitigating stress-induced damages has gained interest in the past few years. However, the protective mechanism HS and/or NO has towards the chloroplast system through the regulation of redox status and activation of antioxidant capacity in cobalt-treated wheat remain largely unanswered. Triticum aestivum L. Read More

J Photochem Photobiol B 2020 Mar 8;204:111783. Epub 2020 Jan 8.

Center of Research Excellence in Desalination & Water Treatment, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia; Center for Environment and Water, King Fahd University of Petroleum and Minerals, Dhahran 31261¸ Saudi Arabia; Department of Mechanical Engineering, King Fahd University of Petroleum and Minerals, Dhahran 31261¸ Saudi Arabia.

Cadmium sulfide-graphitic carbon nitride nanocomposite was synthesized by pulsed laser ablation in liquid, and it was found from the results of optical and morphological characterizations that the proper anchoring of nanostructured cadmium sulfide on the nano-sheets of graphitic carbon nitride took place, which brought about the positive attributes such as enhanced visible light absorption and reduced photo-generated charge recombination, the key features required for an efficient photo-catalyst by solar light harvesting. The pulsed laser ablation in liquid method adopted for the synthesis of cadmium sulfide-graphitic carbon nitride has the following advantages: the shape and size of the synthesized particles can be controlled by altering the experimental parameters such as laser wavelength, pulse laser duration, the pH of the solution, the surfactants and the temperature of the solution, pulsed laser ablation in liquid method neither requires cumbersome equipment nor does it require intermediate chemicals and catalysts nor does it necessitate the post synthesis purification. The enhancement of photo-catalytic activity of cadmium sulfide-graphitic carbon nitride nanocomposite was tested for the photo-catalytic deactivation of Escherichia coli bacteria in water under visible light radiation. Read More

Bioresour Technol 2020 Apr 28;301:122711. Epub 2019 Dec 28.

Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, HI 96822, United States. Electronic address:

This study examined the use of biochar to alleviate sulfide toxicity to methane producing archaea (MPA) and sulfate-reducing bacteria (SRB) during anaerobic treatment of sulfate-rich wastewater with concomitant sulfur recovery. At the sulfate concentration of 6000 mg SO/L, the dissolved sulfide (DS) of 131 mg S/L resulted in total volatile fatty acids concentration of 3500 mg/L as acetic acid (HAc) and the reactors were on the verge of failure. Biochar removed >98% of HS, 94% of DS, and 89% of unionized sulfide (HS). Read More

Chemosphere 2020 May 14;246:125629. Epub 2019 Dec 14.

Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, China. Electronic address:

In this study, a metabolomic analysis was used to reveal the neurotoxicity of the CdTe/ZnS QDs via microglia polarization. A gas chromatography-mass spectrometer (GC-MS) was applied to uncover the metabonomic changes in microglia (BV-2 cell line) after exposure to 1.25 μM CdTe/ZnS QDs. Read More

Int J Environ Res Public Health 2019 12 28;17(1). Epub 2019 Dec 28.

UCIBIO-Applied Molecular Biosciences Unit, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.

The exponential growth of nanotechnology has led to the production of large quantities of nanomaterials for numerous industrial, technological, agricultural, environmental, food and many other applications. However, this huge production has raised growing concerns about the adverse effects that the release of these nanomaterials may have on the environment and on living organisms. Regarding the effects of QDs on aquatic organisms, existing data is scarce and often contradictory. Read More

Environ Sci Pollut Res Int 2020 Mar 3;27(8):8119-8128. Epub 2020 Jan 3.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Cisplatin (CIS) is an antineoplastic drug able to produce free radicals that are capable to induce various side effects in different tissues. Hydrogen sulfide (HS) has notable antioxidant, anti-apoptotic, and anti-inflammatory effects in different systems but its role in male reproductive system is not fully understood. In the present research, the effect of sodium hydrosulfide (NaHS) on cisplatin-induced testicular toxicity in male rats was studied. Read More

Chem Commun (Camb) 2020 Jan;56(7):1085-1088

Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, USA.

We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels. Read More

J Hazard Mater 2020 03 23;386:121916. Epub 2019 Dec 23.

Environmental Technology, Wageningen University, P.O. Box 17, 6700 AA Wageningen, The Netherlands; Shell, Oostduinlaan 2, 2596 JM the Hague, The Netherlands.

Removal of organic and inorganic sulfur compounds from sour gases is required because of their toxicity and atmospheric pollution. The most common are hydrogen sulfide (HS) and methanethiol (MT). Under oxygen-limiting conditions about 92 mol% of sulfide is oxidized to sulfur by haloalkaliphilic sulfur-oxidizing bacteria (SOB), whilst the remainder is oxidized either biologically to sulfate or chemically to thiosulfate. Read More

Ecotoxicol Environ Saf 2020 Mar 13;190:110069. Epub 2019 Dec 13.

School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong, 250012, PR China. Electronic address:

Carbon disulfide (CS) is regarded as a common occupational poison that is widely used in the textile industry in China. Our previous research suggests that CS can induce significant implantation disorders in pregnant mice; however, the specific mechanism remains unclear. Uterine conception in mice must undergo decidualization, which is the prerequisite for propitious blastocyst implantation into the endometrium. Read More

World J Microbiol Biotechnol 2019 Dec 12;36(1). Epub 2019 Dec 12.

School of Environmental Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.

Colletotrichum gloeosporioides, one of the main agents of mango anthracnose, causes latent infections in unripe mango, and leads to huge economic losses during storage and transport. Dimethyl trisulfide (DMTS), one of the main volatile compounds produced by some microorganisms or plants, has shown antifungal activity against some phytopathogens in previous studies, but its effects on C. gloeosporioides and mechanisms of action have not been well characterized. Read More

Int J Nanomedicine 2019 5;14:9577-9586. Epub 2019 Dec 5.

Key Laboratory of Functional and Clinical Translational Medicine, Department of Basic Medicine, Xiamen Medical College, Xiamen 361023, People's Republic of China.

Purpose: Quantum dots (QDs) are widely used semiconductor nanomaterials. Indium phosphide/zinc sulfide (InP/ZnS) QDs are becoming potential alternatives to toxic heavy metal-containing QDs. However, the potential toxicity and, in particular, the immunotoxicity of InP/ZnS QDs are unknown. Read More

Environ Sci Pollut Res Int 2020 Jan 9;27(1):941-953. Epub 2019 Dec 9.

Biology Department, Education Faculty, Harran University, Sanliurfa, Turkey.

Although thiamine (THI) and hydrogen sulphide (HS) both have widely been tested in the plant under stress conditions, cross talk between THI and HS in the acquisition of cadmium (Cd) stress tolerance needs to be studied. So, an experiment was designed to study the participation of endogenous HS in THI-induced tolerance to Cd stress in strawberry plants. A foliar spray solution containing THI (50 mg L) was sprayed once a week for 4 weeks to the foliage of strawberry plants under Cd stress (1. Read More

Int J Nanomedicine 2019 2;14:9513-9524. Epub 2019 Dec 2.

Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, People's Republic of China.

Background: Early diagnosis of renal cell carcinoma is extremely significant for the effective treatment of kidney cancer. The development of AS1411 aptamer modified Mn-MoS2 QDs provides a promising fluorescence/magnetic resonance (MR) dual-modal imaging probe for the precise diagnosis of renal clear cell carcinoma.

Methods: In this work, Mn-MoS QDs were synthesized through a simple "bottom-up" one-step hydrothermal method. Read More

PLoS One 2019 4;14(12):e0223954. Epub 2019 Dec 4.

McGill University, Department of Human Genetics, Montreal, Canada.

Background: Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidney transplant.15-20% of cystinosis patients harbour at least one nonsense mutation in CTNS, leading to premature end of translation of the transcript. Read More

Chem Commun (Camb) 2019 Dec;56(1):145-148

Department of Chemistry, Tsinghua University, Beijing, China.

The selective measurement of cellular pH at specific regions is significant for the in-depth study of cell functions and pathological processes. Herein, we combined our previously developed rhodamine B-labeled cell-penetrating peptide spirolactam derivative with quantum dots to create a ratiometric nanobiosensor for the simultaneous sensing and imaging of lysosomes and extracellular pH. Read More

Sci Total Environ 2020 Mar 3;708:134831. Epub 2019 Nov 3.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, PR China.

Soil pollution with selenium is a significant environmental problem in several areas of the world, which extremely affects the growth of plants and human health. Thus, it is necessary to find an effective method to immobilize selenium in the soil to make it less bioavailable and less accessible. In this study, the low-cost biochar-supported nanoscale zero-valent iron and polysulfide (PS-nZVI@BC) are produced and used for the immobilization of selenium (Se) in soil. Read More

Soft Matter 2020 Jan 28;16(1):11-26. Epub 2019 Nov 28.

School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Kolkata, 700032, India.

The dynamic nature of the disulfide bond has enhanced the potential for disulfide based amphiphiles in the emerging biomedical field. Disulfide containing amphiphiles have extensively been used for constructing wide ranging soft nanostructures as potential candidates for delivery of drugs, proteins and genes owing to their degradable nature in the presence of intracellular glutathione (present in a many fold excess compared to the extracellular milieu). This degradable nature of amphiphiles is not only useful to deliver therapeutics but it also eliminates the toxicity issues associated with the carrier after delivery of such therapeutics. Read More

Mar Pollut Bull 2020 Jan 23;150:110730. Epub 2019 Nov 23.

Key Laboratory of Mariculture, Ocean University of China, Ministry of Education, Qingdao, China. Electronic address:

Iron is recognized as an efficient method to alleviate sulfide stress. This study tested the response of Zostera marina plants to different levels of sedimentary sulfides (100.0-818. Read More

Fish Shellfish Immunol 2020 Jan 22;96:290-296. Epub 2019 Nov 22.

Engineering Research Center of Ecology and Agricultural Use of Wetland, Ministry of Education, Yangtze University, Jingzhou, 434000, PR China; Hubei Research Institute of Aquatic Industry Technology, Jingzhou, 434000, PR China.

Nitrite and sulfide are harmful pollutants in water ecosystems that negatively influence the survival and growth of crayfish. It is currently known that the intestine of crustaceans acts as a significant immune organ, serving as the front line of defense against diseases. In this study, we investigated how the oxidative damage parameters, antioxidant status and microbial composition of the intestine of Procambarus clarkii were influenced under acute nitrite (60 mg/L) and sulfide (18 mg/L) stress for 72 h. Read More

Biomolecules 2019 11 20;9(12). Epub 2019 Nov 20.

Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

The gut microbiota is a complex component of humans that depends on diet, host genome, and lifestyle. The background: The study purpose is to find relations between nutrition, intestinal lactic acid bacteria (LAB) from various environments (human, animal intestine, and yogurt) and sulfate-reducing microbial communities in the large intestine; to compare kinetic growth parameters of LAB; and to determine their sensitivity to different concentration of hydrogen sulfide produced by intestinal sulfate-reducing bacteria.

Methods: Microbiological (isolation and identification), biochemical (electrophoresis), molecular biology methods (DNA isolation and PCR analysis), and statistical processing (average and standard error calculations) of the results were used. Read More

Macromol Rapid Commun 2020 Jan 22;41(1):e1900531. Epub 2019 Nov 22.

CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, China.

It is of vital importance to reversibly mask and selectively activate bioactive agents for advanced therapeutic and diagnostic purposes, aiming to efficiently suppress background interferences and attenuate systemic toxicity. This strategy has been involved in diverse applications spanning from chemical/biological sensors and diagnostics to drug delivery nanocarriers. Among these, redox-responsive disulfide linkages have been extensively utilized by taking advantage of extracellular and intracellular glutathione (GSH) gradients. Read More

Analyst 2019 Dec;145(1):213-222

Chemistry and Chemical Engineering Institute, Qiqihar University, Qiqihar 161006, China.

Accurate fabrication of fluorescence probes to efficiently monitor and detect H2S levels in the fields of foodstuffs and physiology is crucial. Herein, we report two isomeric phenanthro[9,10-d]imidazole benzene sulfonamide-derived fluorescence probes (PI-2-SA and PI-4-SA), both of which display remarkable responses toward H2S over other analytes. The spectral characteristics of the two probes were investigated and are discussed in detail. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 Mar 31;228:117690. Epub 2019 Oct 31.

School of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. Electronic address:

Design and synthesis of fluorescent probe with fast response, excellent water solubility and good hepatocyte-targeting capacity to detect hydrogen sulfide (HS) in hepatocytes and water samples is of great significance. Here, a novel fluorescent probe QL-Gal-N for detection of HS was designed and synthesized based on HS-mediated azide reduction strategy. This sensor demonstrated low toxicity, fast response (within 1 min), high selectivity and low detection limit (as low as 126 nM in water) for the detection of HS. Read More

Rev Neurosci 2020 Jan;31(2):219-232

School of Social Sciences and Psychology, Western Sydney University, Sydney 2751, New South Wales, Australia.

Treatment-resistant schizophrenia (TRS) is a severe form of schizophrenia. The severity of illness is positively related to homocysteine levels, with high homocysteine levels due to the low activity of the transsulfuration pathway, which metabolizes homocysteine in synthesizing L-cysteine. Glutathione levels are low in schizophrenia, which indicates shortages of L-cysteine and low activity of the transsulfuration pathway. Read More

Antioxid Redox Signal 2020 01;32(2):79-95

Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia.

Cell homeostasis and redox balance are regulated in part by hydrogen sulfide (HS), a gaseous signaling molecule known as a gasotransmitter. Given its biological roles, HS has promising therapeutic potential, but controlled delivery of this reactive and hazardous gas is challenging due to its promiscuity, rapid diffusivity, and toxicity at high doses. Macromolecular and supramolecular drug delivery systems are vital for the effective delivery of many active pharmaceutical ingredients, and HS stands to benefit greatly from the tunable physical, chemical, and pharmacokinetic properties of polymeric and/or self-assembled drug delivery systems. Read More

Molecules 2019 Nov 2;24(21). Epub 2019 Nov 2.

Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Copper is the most common metal catalyst used in atom transfer radical polymerization (ATRP), but iron is an excellent alternative due to its natural abundance and low toxicity compared to copper. In this work, two new iron-porphyrin-based catalysts inspired by naturally occurring proteins, such as horseradish peroxidase, hemoglobin, and cytochrome P450, were synthesized and tested for ATRP. Natural protein structures were mimicked by attaching imidazole or thioether groups to the porphyrin, leading to increased rates of polymerization, as well as providing polymers with low dispersity, even in the presence of ppm amounts of catalysts. Read More

Sci Total Environ 2020 Jan 4;699:134296. Epub 2019 Sep 4.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Hydrogen sulfide (HS) is an air pollutant, has toxic effects on respiratory tract. However, the underlying mechanisms of HS induced respiratory toxicity and the roles of long non-coding RNAs (lncRNA) and microRNA (miRNA) in this process remain poorly understood. To clear this, we investigated the change of tracheal tissue ultrastructure and the expression profiles of lncRNAs and miRNAs of chicken trachea exposed to HS for 42 days. Read More

Environ Toxicol 2020 Mar 4;35(3):322-332. Epub 2019 Nov 4.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe effect of commonly used concentration of NaHS on theliver and its potential damage mechanism. Rats divided into 4 groups: control, NaHS I (1 mg/kg), II (3 mg/kg) and III(5 mg/kg) groups, and each group is divided into four-timepoints (2, 6, 12, and 24 hours). Read More

Biomater Sci 2020 Jan 1;8(1):224-231. Epub 2019 Nov 1.

Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China.

Hydrogen polysulfides (HS, n > 1) belong to sulfane sulfur in the reactive sulfur species (RSS) family and play significant roles in maintaining biological homeostasis in organisms. The detection of HS in living systems is essential, but further understanding of its "intact" function in living cells has been limited, owing to the lack of appropriate analytical tools. In this work, a new fluorescent probe PP-PS was designed for the detection of endogenous HS. Read More

Comp Biochem Physiol B Biochem Mol Biol 2020 Jan 24;239:110367. Epub 2019 Oct 24.

School of Marine Sciences, Ningbo University, Ningbo 315211, PR China.

The razor clam Sinonovacula constricta is a commercial benthic bivalve, and burrows the deeper cave than the other buried benthic bivalves. Due to the little exchange of seawater and to anoxic conditions, S. constricta is exposed to considerable amounts of sulfide during low tide, but exhibits strong sulfide tolerance. Read More

Toxicol Pathol 2019 12 30;47(8):1043-1048. Epub 2019 Oct 30.

Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA.

Nasal pathology can play an important role in the risk assessment process. For example, olfactory neuron loss (ONL) is one of the most sensitive end points seen in subchronic rodent hydrogen sulfide (HS) studies and has been used by several agencies to derive health-protective toxicity values. Alternative methods that rely on computational fluid dynamics (CFD) models to account for the influence of airflow on HS-induced ONL have been proposed. Read More