4,099 results match your criteria Toxicity Hydrogen Sulfide

Hydrogen sulfide disrupts insulin-induced glucose uptake in L6 skeletal muscle cells.

Food Chem Toxicol 2022 May 13;165:113083. Epub 2022 May 13.

Laboratorio de Investigación en Nutrición y Actividad Física (LABINAF), Instituto de Nutrición y Tecnología de Los Alimentos (INTA), Universidad de Chile, Santiago, 7830490, Chile; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, 8380492, Chile. Electronic address:

Hydrogen sulfide (H2S) has been known for its toxicity. However, recent studies have focused on the mechanisms involved in endogenous production and function. To date, the H2S role in insulin signaling and glucose homeostasis is unclear. Read More

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Unmet needs in glaucoma therapy: The potential role of hydrogen sulfide and its delivery strategies.

J Control Release 2022 May 13;347:256-269. Epub 2022 May 13.

School of Pharmacy and Health Professions, Creighton University, Omaha, NE 68178, USA. Electronic address:

Glaucoma is an optic neuropathy disorder marked by progressive degeneration of the retinal ganglion cells (RGC). It is a leading cause of blindness worldwide, prevailing in around 2.2% of the global population. Read More

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TLRs-JNK/ NF-κB Pathway Underlies the Protective Effect of the Sulfide Salt Against Liver Toxicity.

Front Pharmacol 2022 20;13:850066. Epub 2022 Apr 20.

The College, The University of Chicago, Chicago, IL, United States.

Hydrogen sulfide (HS) is an endogenously gas transmitter signaling molecule with known antioxidant, anti-inflammatory, and cytoprotective properties. Although accumulating evidence shows the therapeutic potential of HS in various hepatic diseases, its role in cyclophosphamide (CP)-induced hepatotoxicity remains elusive. The present study was undertaken to investigate the impact of endogenous and exogenous HS on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in CP-induced hepatotoxicity. Read More

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Fabrication of biocompatible magneto-fluorescence nanoparticles as a platform for fluorescent sensor and magnetic hyperthermia applications.

RSC Adv 2021 Oct 1;11(56):35258-35267. Epub 2021 Nov 1.

Department of Physics, Faculty of Science, Kasetsart University Bangkok 10900 Thailand

Multifunctional nanoparticles with special magnetic and optical properties have been attracting a great deal of attention due to their important applications in the bioanalytical and biomedical fields. In this study, we report the fabrication of biocompatible magneto-fluorescence nanoparticles consisting of carbon dots (CDots) and silica-coated cobalt-manganese nanoferrites (CoMnFeO) ([email protected]@CDots) (MagSiCDots) by a facile hydrothermal method. The as-prepared MagSiCDots have a particle size of 100-120 nm and show a negative zeta potential of -35. Read More

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October 2021

Unearthing the alleviatory mechanisms of hydrogen sulfide in aluminum toxicity in rice.

Plant Physiol Biochem 2022 Jul 8;182:133-144. Epub 2022 Apr 8.

State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou, 310006, China. Electronic address:

Hydrogen sulfide (HS) improves aluminum (Al) resistance in rice, however, the underlying mechanism remains unclear. In the present study, treatment with 30-μM Al significantly inhibited rice root growth and increased the total Al content, apoplastic and cytoplasm Al concentration in the rice roots. However, pretreatment with NaHS (HS donor) reversed these negative effects. Read More

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Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.

Food Chem Toxicol 2022 Apr 26;164:113071. Epub 2022 Apr 26.

Xiangya School of Public Health, Central South University, Changsha, 410078, PR China. Electronic address:

Nanoplastics (NaPs) has reported to accumulate in the testes and cause degeneration in the seminiferous tubules. Additionally, exogenous hydrogen sulfide (HS) is proposed to enhance tolerance to oxidative stress. The current work aimed to investigate the mechanisms of NaPs-induced reproductive toxicity in vitro and probable reproductive protection by endogenous HS. Read More

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Synthesis of Dual-Emitting CdZnSe/Mn:ZnS Quantum Dots for Sensing the pH Change in Live Cells.

Anal Chem 2022 May 23;94(18):6665-6671. Epub 2022 Apr 23.

The Faculty of Synthetic Biology, Shenzhen Insitute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Intracellular pH is an important regulator of cell function, and its subtle changes may greatly affect cell activities and cause diseases. Reliable imaging of intracellular pH remains a huge challenge. Dual-emitting Mn-doped quantum dots (QDs) can be directly used as a ratiometric fluorescent probe without further modification, but they displayed low performance in terms of photoluminescence, stability, and intensity ratio regulation. Read More

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Hydrogen sulfide and metal interaction: the pathophysiological implications.

Mol Cell Biochem 2022 Apr 24. Epub 2022 Apr 24.

School of Natural Sciences, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada.

Hydrogen sulfide (HS), previously recognized as a toxic gas, has emerged as an important gaseous signaling molecule along with nitric oxide, carbon monoxide and also hydrogen. HS can be endogenously produced in the mammalian body at a very low level for various pathophysiological processes. Notably, HS can interact with several essential metals in the body such as iron, copper, nickel, and zinc to carry out specific functions. Read More

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Sustainable Synthesis of Cadmium Sulfide, with Applicability in Photocatalysis, Hydrogen Production, and as an Antibacterial Agent, Using Two Mechanochemical Protocols.

Nanomaterials (Basel) 2022 Apr 7;12(8). Epub 2022 Apr 7.

General and Inorganic Chemistry Department, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, Kazakhstan.

CdS nanoparticles were successfully synthesized using cadmium acetate and sodium sulfide as Cd and S precursors, respectively. The effect of using sodium thiosulfate as an additional sulfur precursor was also investigated (combined milling). The samples were characterized by XRD, Raman spectroscopy, XPS, UV-Vis spectroscopy, PL spectroscopy, DLS, and TEM. Read More

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Humic acid promoted activation of peroxymonosulfate by FeS for degradation of 2,4,6-trichlorophenol: An experimental and theoretical study.

J Hazard Mater 2022 07 14;434:128913. Epub 2022 Apr 14.

Institute for Environmental pollution and health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address:

Chlorophenols are difficult to degrade and biohazardous in the natural environment. This study demonstrated that humic acid (HA) could promote FeS activation of peroxymonosulfate (PMS) to degrade 2,4,6-trichlorophenol (TCP), the degradation efficiency of TCP was increased by 33%. The system of FeS-HA/PMS produced more reactive oxygen species, and •OH was the dominant ROS. Read More

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Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents.

J Nanobiotechnology 2022 Apr 12;20(1):185. Epub 2022 Apr 12.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 199 Renai Rd, Suzhou, 215123, Jiangsu Province, People's Republic of China.

Albumin-biomineralized copper sulfide nanoparticles (CuS NPs) have attracted much attention as an emerging phototheranostic agent due to their advantages of facile preparation method and high biocompatibility. However, comprehensive preclinical safety evaluation is the only way to meet its further clinical translation. We herein evaluate detailedly the safety and hepatotoxicity of bovine serum albumin-biomineralized CuS ([email protected]) NPs with two different sizes in rats. Read More

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Recent Advances in the Applications of Green Synthesized Nanoparticle Based Nanofluids for the Environmental Remediation.

Curr Pharm Biotechnol 2022 Apr 11. Epub 2022 Apr 11.

Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.

With the ever-growing importance of green technology, the utilization of inorganic metal oxide nanoparticles and their nanofluids against microorganisms are garnered more attention than that of organic metal oxides in recent years. Therefore, the utilization of safer, energy and cost-effective natural raw materials, stabilizing agents, and solvents are the fundamental considerations of the greener process. Due to the unique properties, larger surface area to volume ratio, higher stability and selective toxicity towards the microbial pathogens, ZnO, TiO2 and silver nanoparticles are considered to be environment friendly and cost-effective antimicrobial agents. Read More

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Hydrogen sulphide ameliorates hexavalent chromium toxicity in two cereal crops: Role of antioxidant enzymes and proline metabolism.

Plant Biol (Stuttg) 2022 Apr 6. Epub 2022 Apr 6.

Plant Physiology Laboratory, Department of Botany, C.M.P. Degree College, University of Allahabad, Prayagraj, India.

Chromium pollution in soils is a major threat as it reduces crop yields. Hence, researchers seek methods/strategies which could curtail such losses. We report the role of H S in alleviating hexavalent chromium [Cr(VI)] stress in two cereals crops, i. Read More

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An amperometric glucose biosensor based on electrostatic force induced layer-by-layer GOD/chitosan/pyrite on a glassy carbon electrode.

Anal Sci 2022 Mar 1;38(3):553-562. Epub 2022 Apr 1.

School of Chemical Engineering, University of Science and Technology Liaoning, 185 Qianshan Middle Road, High-Tech Zone, Anshan, 114051, Liaoning, China.

Pyrite (PR), as a representative sulfide mineral, possesses the advantages of abundancy, thermodynamic stability, non-toxicity and semi-conductivity. In this study, an amperometric glucose biosensor (GOD/CS/PR/GCE) based on layer-by-layer of glucose oxidase (GOD), chitosan (CS) and pyrite (PR) on a glassy carbon electrode (GCE) was fabricated through electrostatic force. In this research, PR suspension prepared in phosphate buffer (pH 5. Read More

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A novel HO activated NIR fluorescent probe for accurately visualizing HS fluctuation during oxidative stress.

Anal Chim Acta 2022 Apr 2;1202:339670. Epub 2022 Mar 2.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China. Electronic address:

Hydrogen sulfide (HS) is a typical gas signal molecule that plays a vital role in various pathological courses. Despite having the accumulated knowledge on the physiological functions of HS in many diseases, the process in the measurement of its level in mitochondria during oxidative stress is still far away from the expectation. In this regard, it is great significant to design a fluorescent probe for accurately monitoring the dynamics of HS during oxidative stress. Read More

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The Feline Calicivirus Leader of the Capsid Protein Has the Functional Characteristics of a Viroporin.

Viruses 2022 03 18;14(3). Epub 2022 Mar 18.

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Av. IPN 2508. Col. San Pedro Zacatenco, Mexico City 07360, Mexico.

The leader of the capsid (LC) protein is exclusive to the genus, and it is needed for successful feline calicivirus (FCV) replication, as well as an efficient apoptosis induction through the mitochondrial pathway. In this work, we aimed to determine if the LC protein from the FCV is a viroporin. Although lacking in a transmembrane domain or an amphipathic helix, the LC protein from the FCV is toxic when expressed in bacteria and it oligomerizes through disulfide bonds, which are both key characteristics of viroporins. Read More

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How to Differentiate General Toxicity-Related Endocrine Effects from Endocrine Disruption: Systematic Review of Carbon Disulfide Data.

Int J Mol Sci 2022 Mar 15;23(6). Epub 2022 Mar 15.

Risk Assessment Department, ANSES, 14 Rue Pierre et Marie Curie, 94701 Maisons-Alfort, France.

This review provides an overview of the assessment of the endocrine disrupting (ED) properties of carbon disulfide (CS), following the methodology used at the European level to identify endocrine disruptors. Relevant in vitro, in vivo studies and human data are analyzed. The assessment presented here focuses on one endocrine activity, i. Read More

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Simple Zn-Mediated Seleno- and Thio-Functionalization of Steroids at C-1 Position.

Int J Mol Sci 2022 Mar 11;23(6). Epub 2022 Mar 11.

Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06132 Perugia, Italy.

Here we report the reaction in the biphasic system of the in situ prepared selenols and thiols with 1,4-androstadiene-3,17-dione () or prednisone acetate () having α,β-unsaturated ketone as an electrophilic functionalization. The Michael-type addition reaction resulted to be chemo- and stereoselective, affording a series of novel steroidal selenides and sulfides. This is an example of a one-step, eco-friendly process that bypasses some of the main concerns connected with the bad smell and the toxicity of these seleno- and thio-reagents. Read More

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A Comprehensive Evaluation of Sdox, a Promising HS-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors.

Front Pharmacol 2022 7;13:831791. Epub 2022 Mar 7.

Department of Life Sciences, University of Siena, Siena, Italy.

Sdox is a hydrogen sulfide (HS)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment of Sdox drug-like features and its absorption, distribution, metabolism, and excretion (ADME)/toxicity properties, by a multi- and transdisciplinary , , and approach. Doxorubicin was used as the reference compound. Read More

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Activation of peroxymonosulfate by natural pyrite for efficient degradation of V(IV)-citrate complex in groundwater.

J Colloid Interface Sci 2022 Jul 15;617:683-693. Epub 2022 Mar 15.

School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide SA5005, Australia. Electronic address:

The V(IV)-organic complexes are difficult to be removed from water by the traditional water treatment processes due to their strong mobility, high stability, and possible formation of V(V) with stronger toxicity during oxidation. In this study, we applied a natural iron-based ore, pyrite, to catalyze peroxymonosulfate (PMS) activation assisted with alkali precipitation to remove V(IV) containing complexes. The effects of initial V(IV)-citrate concentration, PMS concentration, ore dosage and natural anions were comprehensively investigated using citric acid as a model ligand. Read More

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Improvement of autophagic flux mediates the protection of hydrogen sulfide against arecoline-elicited neurotoxicity in PC12 cells.

Cell Cycle 2022 May 22;21(10):1077-1090. Epub 2022 Mar 22.

Department of Physiology, Institute of Neuroscience, Hengyang Medical School, University of South China, Hengyang, HN, China.

Arecoline, the most abundant alkaloid of the areca nut, induces toxicity to neurons. Hydrogen sulfide (HS) is an endogenous gas with neuroprotective effects. We recently found that arecoline reduced endogenous HS content in PC12 cells. Read More

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Regionalized Life Cycle Inventories of Global Sulfidic Copper Tailings.

Environ Sci Technol 2022 Apr 16;56(7):4553-4564. Epub 2022 Mar 16.

Institute of Environmental Engineering, ETH Zurich, Zurich 8093, Switzerland.

Worldwide, an issue of copper production is the generation of mine waste with varying characteristics. This waste can pollute natural environments, and in particular, the heavy metal emissions of the tailings may pose long-term consequences. Currently, life cycle assessments of mine tailings are hampered by both limited data availability in the metal production value chain and lack of appropriate methodologies. Read More

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Heterogeneous-Backbone Proteomimetic Analogues of Lasiocepsin, a Disulfide-Rich Antimicrobial Peptide with a Compact Tertiary Fold.

ACS Chem Biol 2022 04 15;17(4):987-997. Epub 2022 Mar 15.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

The emergence of resistance to clinically used antibiotics by bacteria presents a significant problem in public health. Natural antimicrobial peptides (AMPs) are a valuable source of antibiotics that act by a mechanism less prone to the evolutionary development of resistance. In an effort to realize the promise of AMPs while overcoming limitations such as poor biostability, researchers have sought sequence-defined oligomers with artificial amide-based backbones that show membrane-disrupting functions similar to natural agents. Read More

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Photon-induced redox chemistry on pyrite promotes photoaging of polystyrene microplastics.

Sci Total Environ 2022 Jul 11;829:154441. Epub 2022 Mar 11.

College of Environmental Science and Engineering, Guilin University of Technology, Guilin, Guangxi 541000, China. Electronic address:

The mineral particles in sediment could affect polystyrene microplastics (PS-MPs) prosperity through physical and chemical interactions. Pyrite with semiconducting properties is the most abundant metal sulfide mineral in the sediments of lake and river mouths. The widespread sunlight and the coexistence of PS-MPs and pyrite in lake or river water due to frequently water fluctuation is a typical photoaging environment for PS-MPs. Read More

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The Defensive Role of Endogenous HS in against Mercury-Selenium Combined Stress.

Int J Mol Sci 2022 Mar 5;23(5). Epub 2022 Mar 5.

Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

Plants are always exposed to the environment, polluted by multiple trace elements. Hydrogen sulfide (HS), an endogenous gaseous transmitter in plant cells, can help plant combat single elements with excess concentration. Until now, little has been known about the regulatory role of HS in response to combined stress of multiple elements. Read More

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Molybdenum disulfide (MoS)-based nanostructures for tissue engineering applications: prospects and challenges.

J Mater Chem B 2022 Apr 13;10(15):2761-2780. Epub 2022 Apr 13.

School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Korea.

Molybdenum disulfide (MoS) nanostructures have recently earned substantial thoughts from the scientific communities owing to their unique physicochemical, optical and electrical properties. Although MoS has been mostly highlighted for its industrial applications, its biological applicability has not been extensively explored. The introduction of nanotechnology in the field of tissue engineering has significantly contributed to human welfare by displaying advancement in tissue regeneration. Read More

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Exogenous HS reverses high glucose-induced endothelial progenitor cells dysfunction via regulating autophagy.

Bioengineered 2022 01;13(1):1126-1136

Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, (Shenzhen Sun Yat-sen Cardiovascular Hospital), Shenzhen, China.

This study aims to determine the effect of exogenous hydrogen sulfide (HS) under high glucose (HG)-induced injury in endothelial progenitor cells (EPCs), and to explore the possible underlying mechanisms. Mononuclear cells were isolated from the peripheral blood of healthy volunteers by density-gradient centrifugation and identified as late EPCs by immunofluorescence and flow cytometry. EPCs were treated with high concentrations of glucose, HS, Baf-A1, 3-MA or rapamycin. Read More

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January 2022

Parental exposure to CdSe/ZnS QDs affects cartilage development in rare minnow (Gobiocypris rarus) offspring.

Comp Biochem Physiol C Toxicol Pharmacol 2022 Jun 5;256:109304. Epub 2022 Mar 5.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Southwest University School of Life Sciences, Chongqing 400715, China. Electronic address:

Cartilage development is a sensitive process that is easily disturbed by environmental toxins. In this study, the toxicity of CdSe/ZnS quantum dots on the skeleton of the next generation (F1) was evaluated using rare minnows (Gobiocypris rarus) as model animals. Four-month-old sexually mature parental rare minnows (F0) were selected and treated with 0, 100, 200, 400 and 800 nmol/L CdSe/ZnS quantum dots for 4 days. Read More

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The Critical Role of Environmental Synergies in the Creation of Bionanohybrid Microbes.

Appl Environ Microbiol 2022 04 15;88(7):e0232121. Epub 2022 Mar 15.

Department of Chemical and Petroleum Engineering, University of Calgarygrid.22072.35, Calgary, Canada.

A wide range of bacteria can synthesize surface-associated nanoparticles (SANs) through exogenous metal ions reacting with sulfide produced via cysteine metabolism, resulting in the emergence of a biological-nanoparticle hybrid (bionanohybrid). The attached nanoparticles may couple to extracellular electron transfer, facilitating photoelectrochemical processes. While SAN-cell coupling in hybrid organisms is opening a range of biotechnological possibilities, observation of bionanohybrids in nature is not commonly reported and their lab-based behavior remains difficult to control. Read More

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Arsenic 3 methyltransferase (AS3MT) automethylates on cysteine residues in vitro.

Arch Toxicol 2022 05 4;96(5):1371-1386. Epub 2022 Mar 4.

Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, Québec, H3T 1E2, Canada.

Arsenic toxicity is a global concern to human health causing increased incidences of cancer, bronchopulmonary, and cardiovascular diseases. In human and mouse, inorganic arsenic (iAs) is metabolized in a series of methylation steps catalyzed by arsenic (3) methyltransferase (AS3MT), forming methylated arsenite (MAsIII), dimethylarsenite (DMAIII) and the volatile trimethylarsine (TMA). The methylation of arsenic is coordinated by four conserved cysteines proposed to participate in catalysis, namely C33, C62, C157, and C207 in mouse AS3MT. Read More

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