Search Our Scientific Publications & Authors

Toxicol Lett 2019 Apr 11;310:39-50. Epub 2019 Apr 11.

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.

This study explored the role of gasotransmitters in lead-induced nephrotoxicity. Long-term exposure of rats to lead resulted in its accumulation in kidney. The accumulated metal impaired kidney function and structure. Read More

Plant Cell Environ 2019 Apr 2. Epub 2019 Apr 2.

College of Life Sciences, Henan Normal University, Xinxiang, Henan, 453007, China.

Hydrogen sulfide (H S) is emerging as an important signaling molecule involved in plant resistance to various stresses. However, the underlying mechanism of H S in aluminum (Al) resistance and the crosstalk between H S and nitric oxide (NO) in Al stress signaling remain elusive. Citrate secretion is a wide-spread strategy for plants against Al toxicity. Read More

Cell Death Dis 2019 Mar 29;10(4):293. Epub 2019 Mar 29.

Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.

Hydrogen sulfide (HS) serves as a gasotransmitter in the regulation of organ development and maintenance of homeostasis in tissues. Its abnormal levels are associated with multiple human diseases, such as neurodegenerative disease, myocardial injury, and ophthalmic diseases. Excessive exposure to HS could lead to cellular toxicity, orchestrate pathological process, and increase the risk of various diseases. Read More

J Cell Physiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky.

Homocysteine (Hcy) is detrimental to bone health in a mouse model of diet-induced hyperhomocysteinemia (HHcy). However, little is known about Hcy-mediated osteoblast dysfunction via mitochondrial oxidative damage. Hydrogen sulfide (H S) has potent antioxidant, anti-inflammatory, and antiapoptotic effects. Read More

Am J Med Genet A 2019 Mar 12. Epub 2019 Mar 12.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Ethylmalonic encephalopathy (EE) is a rapidly progressive autosomal recessive mitochondrial disease caused by biallelic pathogenic variants in the ETHE1 gene that encodes the mitochondrial sulfur dioxygenase. It is characterized by neurodevelopmental delay and regression, pyramidal and extrapyramidal signs, recurrent petechiae, chronic diarrhea, and orthostatic acrocyanosis. Laboratory findings include elevated serum levels of lactate and C4-C5 acylcarnitines, and elevated urinary excretion of ethylmalonic acid and C4-C6 acylglycines, notably isobutyrylglycine and 2-methylbutyrylglycine. Read More

Plant Physiol Biochem 2019 May 2;138:100-111. Epub 2019 Mar 2.

Guangxi Academy of Agricultural Sciences, Nanning, 530007, China.

Hydrogen sulfide (HS) modulates plant tolerance to abiotic stresses, but its regulatory effects on nitrogen metabolism and chloroplast protection under nickel (Ni) stress in crop plants remain elusive. Taking this into account, we investigated the potential roles of sodium hydrosulfide (NaHS), a HS generator, in the improvement of growth performance of rice plants under Ni stress. Results showed that NaHS successfully reversed the adverse effects of Ni, as reflected in plant growth and biomass, and photosynthesis attributes including photosynthetic rates, stomatal conductance, transpiration rate, internal CO concentration and photosynthetic pigment contents. Read More

Chemosphere 2019 Jun 28;224:554-561. Epub 2019 Feb 28.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China.

Hydrogen sulfide (HS), an important cellular signaling molecule, plays vital roles in mediating responses to biotic/abiotic stresses. Influences of HS on metal removal, cell viability, and antioxidant response of Phanerochaete chrysosporium upon exposure to heavy metals and silver nanoparticles (AgNPs) in the present study were investigated. An enhancement in Pb(ΙΙ) removal with an increase in concentration of the HS donor sodium hydrosulfide (NaHS) was observed, and the maximum removal efficiencies increased by 31% and 17% under 100 and 200 mg/L Pb(ΙΙ) exposure, respectively, in the presence of 500 μM NaHS. Read More

Br J Pharmacol 2019 Mar 4. Epub 2019 Mar 4.

National Institute of Oncology, Budapest, Hungary.

Background And Purpose: ATB-346 is a hydrogen sulfide (H S)-releasing anti-inflammatory and analgesic drug. Animal studies demonstrated negligible gastrointestinal (GI) damage despite marked inhibition of COX activity and significant analgesic and anti-inflammatory effects. In humans, ATB-346 (250 mg once daily) was found to inhibit COX to the same extent as naproxen (550 mg twice daily). Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 May 20;214:487-495. Epub 2019 Feb 20.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China. Electronic address:

In this work, we have designed and synthesized a dinitrobenzene-sulfonate tetrahydro[5]helicene (H-DNP) as an effective fluorescent probe for detection of hydrogen sulfide (HS). Upon the addition of HS, a significant fluorescence enhancement (75-fold) at 495 nm can be observed with a distinct color change from colorless to yellow. Additionally, H-DNP shows low background spectroscopic signal, large Stokes Shift up to ~140 nm, good sensitivity, rapid response time less than 2 min, low detection limit (48 nM) and high selectivity toward common bio-thiols (Cysteine, Homocysteine and Glutathione). Read More

Comp Biochem Physiol C Toxicol Pharmacol 2019 May 22;219:77-86. Epub 2019 Feb 22.

Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15219, USA. Electronic address:

Caterpillars of the greater wax moth, Galleria mellonella, are shown to be a useful invertebrate organism for examining mitochondrial toxicants (inhibitors of electron transport) and testing putative antidotes. Administration of sodium azide, sodium cyanide, or sodium (hydro)sulfide by intra-haemocoel injection (through a proleg) results in a dose-dependent paralysed state in the larvae lasting from <1 to ~40 min. The duration of paralysis is easily monitored, because if turned onto their backs, the larvae right themselves onto their prolegs once they are able to move again. Read More

Int J Nanomedicine 2019 30;14:875-888. Epub 2019 Jan 30.

Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200030, China,

Background: Hydrogen sulfide (HS) has shown promising therapeutic benefits in reversing a variety of pathophysiological processes in cardiovascular system, including myocardial ischemia-reperfusion (IR) injury. However, the achievement of controlled and sustained release of HS has been a technical bottleneck that limits the clinical application of the gas molecule.

Methods: The current study describes the development of mesoporous iron oxide nanoparticles (MIONs) which were loaded with diallyl trisulfide (DATS), a HS donor compound, and calibrated by stimulated Raman scattering/transient absorption. Read More

Int J Mol Sci 2019 Feb 17;20(4). Epub 2019 Feb 17.

Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.

Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the metabolism of the essential amino acid methionine. Hcy is considered a risk factor for atherosclerosis and cardiovascular disease (CVD), but the molecular basis of these associations remains elusive. The impairment of endothelial function, a key initial event in the setting of atherosclerosis and CVD, is recurrently observed in hyperhomocysteinemia (HHcy). Read More

Open Med (Wars) 2019 16;14:66-74. Epub 2019 Jan 16.

Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.

Lower intraluminal colonic pH is an indication for the development of inflammatory bowel disease including active ulcerative colitis. Involvement of intestinal sulfate-reducing bacteria in decreasing bowel pH by the production of HS and acetate as well as their sensitivity has never been reported before. The study of the relative pH and survival of Vib-7 by monitoring sulfate reduction parameters was the aim of this work. Read More

Talanta 2019 May 26;197:1-11. Epub 2018 Dec 26.

School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan, PR China. Electronic address:

In this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA-AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and low toxicity. Based on these superior properties, the AuNCs have been multi-talented applied in cell imaging, hydrogen sulfide detection and pH sensing. Read More

J Enzyme Inhib Med Chem 2019 Dec;34(1):361-374

a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education , Shanghai Jiao Tong University, School of Medicine , Shanghai , China.

Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kinase domain that is topographically distinct from the orthosteric, ATP binding site. Allosteric modulators by attaching to the less conserved PIF-pocket have remarkable advantages such as higher selectivity, less side effect, and lower toxicity. Read More

J Toxicol Sci 2019 ;44(2):107-112

Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.

Inhalation of toxic gases is dangerous to humans; experiments using toxic gases themselves are also hazardous to researchers. Gas-releasing molecules are widely used as alternatives to toxic gases, but their impacts on the whole body remain to be examined. To investigate responses during hydrogen sulfide (HS) poisoning, rats (Sprague-Dawley, male, 8-week-old) were intraperitoneally (i. Read More

J Comp Physiol B 2019 Apr 4;189(2):223-235. Epub 2019 Feb 4.

Department of Integrative Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada.

We investigated amphibious behaviour, hydrogen sulphide (HS) tolerance, and the mechanism of HS toxicity in the amphibious mangrove rivulus (Kryptolebias marmoratus). We found that fish emersed (left water) in response to acutely elevated [HS] (~ 130-200 µmol l). The emersion response to HS may be influenced by prior acclimation history due to acclimation-induced alterations in gill morphology and/or the density and size of neuroepithelial cells (NECs) on the gills and skin. Read More

Arch Microbiol 2019 Apr 1;201(3):389-397. Epub 2019 Feb 1.

Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.

Sulfate-reducing bacteria (SRB) belonging to the intestinal microbiota are the main producers of hydrogen sulfide and their increasing amount due to the accumulation of this compound in the bowel are involved in the initiation and maintenance of inflammatory bowel disease. The purpose of this experiment is to study the relative toxicity of hydrogen sulfide and survival of Desulfovibrio piger Vib-7 through monitoring: sulfate reduction parameters (sulfate consumption, hydrogen sulfide production, lactate consumption and acetate production) and kinetic parameters of these processes. The research is highlighting the survival of intestinal SRB, D. Read More

J Photochem Photobiol B 2019 Mar 7;192:68-73. Epub 2019 Jan 7.

Department of Nursing, The Third Xiangya Hospital of Central South University, Yuelu district, Changsha, Hunan province 410013, PR China.

The purpose of this report was to progress the advancement of nanotechnology combined with near-infrared (NIR) laser-mediated treatment for enhancing efficiency against breast cancer (MCF-7) cells. The physic-chemical interactions and properties of the surface improved nano-Graphene oxide (nGO) sheets with Copper Sulfide (CuS) quantum dots were analyzed by selected exclusive analytical methods. The cytotoxicity effect of nGO was investigated by various in vitro assays. Read More

J Hazard Mater 2019 Apr 22;368:243-254. Epub 2019 Jan 22.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Hydrogen sulfide (HS) is well known to cause irritation and damage to airway following inhalation, but the mechanism by which HS contributes to airway toxicity is unclear. In order to assess the respiratory toxicity of HS inhalation in chicken trachea, we investigated the change of oxidative stress parameters, tracheal tissue structure and transcriptome profiles of chicken trachea exposed to HS for 42 days. The results showed HS exposure induced oxidative stress and inflammation in trachea. Read More

Chemosphere 2019 Mar 11;219:1014-1023. Epub 2018 Dec 11.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Algal blooms decay affects the mobility, bioavailability, and toxicity of arsenic (As) in aquatic environments. The decaying process alters aquatic redox conditions and also introduces ample organic matter, conditions favorable for microbial reduction to simulate As release and As species transformation. This study investigated the role of algae (Microcystis aeruginosa (MA)) blooms decay on the dynamics of labile As and elements associated with its release, such as iron (Fe), manganese (Mn) and sulfide (S), at the sediment-water surface (SWI) of a shallow lake (Lake Taihu) in China, applying mesocosm incubation. Read More

Prostaglandins Other Lipid Mediat 2019 04 15;141:1-10. Epub 2019 Jan 15.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt. Electronic address:

We recently reported that celecoxib, a selective cyclooxygenase-2 (COX2) inhibitor, counteracts the adverse circulatory and renal actions of cyclosporine (CSA). Despite the seemingly advantageous nature of this interaction particularly in clinical settings that necessitate the combined use of the two drugs such as immune-related arthritis, the underlying mechanism remains elusive. This prompted us to test the hypothesis that the facilitation of the cystathionine-γ-lyase (CSE)/hydrogen sulfide (HS) signaling accounts for such favorable effects of celecoxib on CSA nephrotoxicity. Read More

Redox Biol 2019 02 8;21:101102. Epub 2019 Jan 8.

Magnetic Resonance Center - CERM, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy; Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

Cadmium is a toxic pollutant that in recent decades has become more widespread in the environment due to anthropogenic activities, significantly increasing the risk of exposure. Concurrently, a continually growing body of research has begun to enumerate the harmful effects that this heavy metal has on human health. Consequently, additional research is required to better understand the mechanism and effects of cadmium at the molecular level. Read More

ACS Chem Biol 2019 Feb 17;14(2):170-175. Epub 2019 Jan 17.

Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology , University of Oregon , Eugene , Oregon 97403 , United States.

Hydrogen sulfide (HS) is an important gasotransmitter and biomolecule, and many synthetic small-molecule HS donors have been developed for HS-related research. One important class of triggerable HS donors is self-immolative thiocarbamates, which function by releasing carbonyl sulfide (COS), which is rapidly converted to HS by the ubiquitous enzyme carbonic anhydrase (CA). Prior studies of esterase-triggered thiocarbamate donors reported significant inhibition of mitochondrial bioenergetics and toxicity when compared to direct sulfide donors, suggesting that COS may function differently than HS. Read More

Ann Plast Surg 2019 Apr;82(4):452-458

University of Pittsburgh Medical Center, Pittsburgh, PA.

Introduction: Vascularized composite allotransplantation can reconstruct devastating tissue loss by replacing like-with-like tissues, most commonly in the form of hand or face transplantation. Unresolved technical and ethical challenges have meant that such transplants remain experimental treatments. The most significant barrier to expansion of this field is the requirement for systemic immunosuppression, its toxicity and effect on longevity. Read More

Talanta 2019 Apr 10;195:850-856. Epub 2018 Dec 10.

Department of Pharmacology, Department of Medicinal Chemistry, Qingdao University School of Pharmacy, Qingdao 266021, China. Electronic address:

Hydrogen sulfide or HS is known as an important gasotransmitter involved in regulation of many physiological and pathological processes. Since a small amount of HS is produced by endogenous cells in the body and microorganisms in the gastrointestinal tract (GI tract), the current detection probes are limited for their use in measurement of unpretentious change of HS level both in vitro and in vivo. Therefore, development of a highly sensitive and responsive fluorescent probe for measurement of HS in vivo is of great significance for investigation of HS function and toxicity. Read More

Mikrochim Acta 2019 01 7;186(2):58. Epub 2019 Jan 7.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.

The authors describe a fluorometric strategy for the determination of dopamine (DA). It is based on the use of aptamer-functionalized MoS quantum dots (QDs) and MoS nanosheets (NSs). The QDs and NSs were extensively characterized with regard to their physical and chemical properties using methods such as TEM, XRD, FT-IR, EDX and molecular spectroscopies. Read More

Mater Sci Eng C Mater Biol Appl 2019 Mar 17;96:129-137. Epub 2018 Oct 17.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, PR China.

In this study, we report a smart and green strategy to synthesize copper sulfide nanoparticles (CuS-NPs) for clinically translatable cancer treatment. For the first time, the preparation of CuS-NPs was developed by taking advantage of the copper-amine complex as the copper source and sodium sulfide as the sulfide source, in which the quaternized chitosan (QCS) was used as a biotemplate and stabilizing agent. The obtained QCS/CuS-NPs composites (CuS@QCS-NPs) were spherical and stable with an average diameter of 5. Read More

Pulm Pharmacol Ther 2019 02 31;54:77-86. Epub 2018 Dec 31.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

GYY4137, a slow-releasing hydrogen sulfide (HS) donor, has been reported to exert anti-inflammatory activity and protect against sepsis. Heme oxygenase-1 (HO-1) is an important anti-inflammatory heat shock protein and plays a similar effect on sepsis. This study investigated the role of GYY4137 in acute lung injury (ALI) via HO-1 regulation. Read More

Int Urol Nephrol 2019 Apr 2;51(4):745-754. Epub 2019 Jan 2.

Department of Biology, Faculty of Science and Literature, Kutahya Dumlupinar University, Kutahya, Turkey.

Introduction And Aim: Hydrogen sulfide (HS) is an endogenously produced gas-structure mediator. It is proposed to have antioxidant, anti-inflammatory and antiapoptotic effects. Acetaminophen (N-acetyl-P-aminophenol; APAP) is an antipyretic and analgesic medication known as paracetamol. Read More

Ecotoxicol Environ Saf 2019 Mar 29;169:778-785. Epub 2018 Nov 29.

Colleges of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong Province, China. Electronic address:

Metal pyrithiones (MePTs) are frequently used antifouling biocides in marine coatings. Their main degradation product, 2,2'-dithiobis-pyridine ((PS)), has been widely detected in seawater and may pose potential ecological risks. In the present study, sexually mature guppies (Poecilia reticulata) were exposed to (PS) at concentrations of 0, 20, 200, and 2000 ng/L for 28 days to investigate its reproductive toxicity. Read More

Chemosphere 2019 Apr 23;220:523-530. Epub 2018 Dec 23.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.

Sulfide-modified nanoscale zero-valent iron (S/nZVI) has been widely studied for groundwater remediation, but the potential environmental risks are poorly understood. This study examined the toxicity of S/nZVI to Escherichia coli in aqueous solutions. The sulfidation could reduce toxicity of nZVI, and S/nZVI exhibited a weaker toxicity at lower Fe/S molar ratio, resulting from the lower Fe content and higher sulfate and iron oxide. Read More

Toxicol Sci 2019 Apr;168(2):443-459

Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Exposure to toxic levels of hydrogen sulfide (H2S) produces an acute cardiac depression that can be rapidly fatal. We sought to characterize the time course of the cardiac effects produced by the toxicity of H2S in sheep, a human sized mammal, and to describe the in vivo and in vitro antidotal properties of methylene blue (MB), which has shown efficacy in sulfide intoxicated rats. Infusing NaHS (720 mg) in anesthetized adult sheep produced a rapid dilation of the left ventricular with a decrease in contractility, which was lethal within about 10 min by pulseless electrical activity. Read More

J Agric Food Chem 2019 Jan 20;67(1):433-440. Epub 2018 Dec 20.

School of Agronomy , Anhui Agricultural University , Hefei 230036 , People's Republic of China.

The association between hydrogen sulfide (HS) and cell wall composition with regard to the mitigation of cadmium (Cd) toxicity in Brassica napus L. was investigated. Cd caused growth retardation, leaf chlorosis, and decreased endogenous HS content in Brassica napus roots. Read More

Methods Appl Fluoresc 2018 Dec 17;7(1):014002. Epub 2018 Dec 17.

State Key Laboratory of Chemo/Bio-sensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.

Hydrogen sulfide is an important gasotransmitter that exhibits various functions in physiological processes. We present a ratiometric fluorescence probe (SN-N) for HS by functionalizing naphthalene imide with 4-(azidomethyl)benzene as a HS recognition moiety and morpholine moiety as a lysosomal targeting unit. After reaction with HS, the azido moiety is reduced to amine group, and the probe releases the self-immolative linker and regenerates the fluorophore with internal charge transfer effect. Read More

Drug Des Devel Ther 2018 14;12:3913-3927. Epub 2018 Nov 14.

Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China,

Purpose: Gastric and colon cancers have been the leading causes of cancer mortality in the world with limited therapy. Small molecules binding to bromodomains of bromodomain-containing protein 4 (BRD4) exert strong antitumor activities against hematological malignancies, while generally have limited efficacy in advanced solid tumors. Here, we found that the bromodomain and extra-terminal (BET)-bromodomain inhibitor JQ1, when combined with arsenic sulfide (AsS, abbreviated as AS), synergistically decreased the expression of nuclear factor of activated T-cells (NFATs) as well as the downstream oncogene c-Myc and largely induced cell apoptosis via mitochondrial pathway in gastric and colon cancer cell lines. Read More

Environ Sci Pollut Res Int 2019 Jan 27;26(3):2734-2746. Epub 2018 Nov 27.

Department of Energy Science and Technology, Smart Living Innovation Technology Center, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea.

Environmental and health concerns arising from the toxicity of organic dye effluents is still the issue of the twenty-first century. In that regard, this study presents iron sulfide (FeS) for its use in environmental remediation application. Amorphous phase FeS nanowires were synthesized by PVP-assisted solvothermal reaction and were characterized using XRD, XPS, BET, FE-SEM, and EDS techniques. Read More

Neurobiol Dis 2018 Nov 20. Epub 2018 Nov 20.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States.

This special issue will describe cutting-edge translational research on the development of safe and effective therapeutics for treating exposure to toxic chemical threat agents that target the nervous system. These studies are supported by the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program. Chemical threats include chemical warfare agents, pesticides and other toxic chemicals whose primary mode of action is targeted within the nervous system. Read More

J Colloid Interface Sci 2019 Mar 14;537:422-430. Epub 2018 Nov 14.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, People's Republic of China; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, People's Republic of China. Electronic address:

β-HgS quantum dots (QDs) have drawn enormous attention due to the size-tunable bandgap and the lowest quantum state in conduction band which have been applied to semiconductor transistor and photodetector. Though β-HgS is the essential component of Tibetan medicine, the potential toxicity of β-HgS limits its applications, especially in bio-application. Herein, chiral biomolecule enantiomers N-isobutyryl-L(D)-cysteine (L(D)-NIBC) and L(D)-cysteine (L(D)-Cys) were introduced into HgCl and NaS aqueous solution to synthesize chiral β-HgS QDs in one-pot, which significantly improved their water-solubility and cytocompatibility. Read More

Nanoscale 2018 Dec 22;10(47):22252-22262. Epub 2018 Nov 22.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.

Nano-drug delivery systems with multi-modality imaging capacities are worth pursuing because they integrate diagnostic and therapeutic functions. Herein, we report the design, synthesis and evaluation of modified iridium sulfide (IrS) nanoparticles (NPs) for cancer therapy in vitro and in vivo. This nanosystem was prepared by modifying IrS with polyethylene glycol (PEG) conjugated to the targeting ligand folate (FA) for multimodal imaging-guided combined chemo-photothermal therapy. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Mar 15;210:212-221. Epub 2018 Nov 15.

Atmospheric Environment & Air Quality Management Lab, Department of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, South Korea.

Herein, a facile one-pot synthetic method was explored for the fabrication of glutathione capped Mn doped‑zinc sulphide quantum dots (GSH-Mn-ZnS QDs) for both fluorescent detection of Cu and Hg ions and for fluorescence imaging of two cancer (RIN5F and MDAMB231) and fungal (Rhizopus oryzae) cells. Particularly, doping of Mn into ZnS QDs nanocrystal structure resulted a great improvement in the fluorescence properties of ZnS QDs. The emission peak of undoped ZnS QDs was found at 447 nm, which is due to the large number of surface defects in the ZnS QDs nanostructures. Read More

J Mol Neurosci 2019 Jan 19;67(1):133-141. Epub 2018 Nov 19.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Methamphetamine (METH) known as a highly neurotoxic compound associated with irreversible brain cell damage that results in neurological and psychiatric abnormalities. The mechanisms of METH intoxication mainly involve intraneuronal events including oxidative stress, excitotoxicity, and dopamine oxidation. Based on recent studies, HS can protect neurons through anti-inflammatory, antioxidant, and antiapoptotic mechanisms. Read More

Clin Toxicol (Phila) 2019 Mar 15;57(3):189-196. Epub 2018 Nov 15.

b Department of Emergency Medicine , University of Colorado, School of Medicine , Aurora , CO , USA.

Introduction: Hydrogen sulfide (HS) is found in petroleum, natural gas, and decaying organic matter. Terrorist groups have attempted to use it in enclosed spaces as a chemical weapon. Mass casualty scenarios have occurred from industrial accidents and release from oil field sites. Read More

Anal Chim Acta 2018 Dec 21;1042:71-78. Epub 2018 May 21.

Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China; Nanjing Normal University Center for Analysis and Testing, Nanjing, 210023, PR China. Electronic address:

An enhanced near-infrared (NIR) FRET biosensing system based on the novel donor-acceptor pair (MnCuInS/ZnS@BSA and urchin-like Au NPs) was developed for the sensitive detection of HER2 protein. In this strategy, MnCuInS/ZnS quantum dots (QDs) were chosen due to their NIR emission, high quantum efficiency, and low toxicity. Amounts of MnCuInS/ZnS QDs were encapsulated in BSA to form MnCuInS/ZnS@BSA nanoparticles, which can easily transfer MnCuInS/ZnS QDs from organic phase into aqueous solution, and the formed nanoparticles were applied as the energy donor which significantly enhanced the fluorescence intensity. Read More

Pest Manag Sci 2019 May 30;75(5):1416-1424. Epub 2018 Dec 30.

Horticulture Department, University of Florida, Balm, FL, USA.

Background: The phaseout of methyl bromide (MeBr) continues to stimulate research into the use of other soil fumigants for controlling soil-borne diseases and weeds. This research evaluated tomato (Solanum lycopersicum L.) tolerance, weed emergence and the recovery of Fusarium oxysporum f. Read More

Eur J Med Chem 2019 Jan 23;161:594-606. Epub 2018 Oct 23.

Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, 92618, United States. Electronic address:

Myocardial toxicity and drug resistance caused by drug efflux are major limitations of doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to develop conjugates with an improved biological profile, such as antiproliferative activity and higher cellular retention. Thus, Dox thiol conjugates, Dox thiol (Dox-SH), thiol-reactive Dox-SS-pyridine (SS = disulfide), and a Dox-SS-cell-penetrating cyclic peptide, Dox-SS-[C(WR)K], were synthesized. Read More

Biometals 2019 02 1;32(1):1-9. Epub 2018 Nov 1.

College of Agronomy, Guangxi University, Nanning, 530004, China.

As gasotransmitter, nitric oxide (NO) and hydrogen sulfide (HS) are involved in the regulation of plant tolerance to abiotic stresses. Aluminum (Al) toxicity triggers synthesis of NO and HS and seriously affects plant growth and productivity. Exogenous NO and HS alleviate Al toxicity in plants. Read More

Integr Environ Assess Manag 2019 Mar 6;15(2):248-258. Epub 2018 Dec 6.

Southern California Coastal Water Research Project, Costa Mesa, California, USA.

Toxicity tests are an important aspect of sediment quality assessments, but knowledge of the cause of toxicity is needed to determine effective management actions. Toxicity identification evaluation (TIE) methods were developed to meet this need. While TIE method manuals provide information on the procedures, little information on study design is presented. Read More

J Nanobiotechnology 2018 Oct 27;16(1):83. Epub 2018 Oct 27.

Department of Medical Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, China.

Background: In order to explore the possibility of treating breast cancer by local photo-therapy, a photothermal agents loaded in situ hydrogel was established. In detail, The CuMnS nanoplates were prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as the hydrogel matrix. The CuMnS nanoplates and the hydrogel were characterized by morphous, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation as well as the rheology features. Read More

Colloids Surf B Biointerfaces 2019 Jan 10;173:607-615. Epub 2018 Oct 10.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei 430062, China. Electronic address:

Copper sulfide nanoparticles(CuS NPs) have attracted considerable interest in the field of photothermal therapy(PTT) due to its low cost, easy preparation and favorable photothermal effect. However, lack of reliable visualization and relatively poor biocompatibility restrict its further bio-application. To overcome these limitations, polydopamine(PDA, a melanin-like biopolymer) stabilized CuS NPs and further chelated with iron ions (denoted as CuPDF) were designed as a versatile nanoplatform for T-weighted MR imaging-guided PTT. Read More