Search Our Scientific Publications & Authors

Int J Mol Sci 2019 Feb 17;20(4). Epub 2019 Feb 17.

Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.

Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the metabolism of the essential amino acid methionine. Hcy is considered a risk factor for atherosclerosis and cardiovascular disease (CVD), but the molecular basis of these associations remains elusive. The impairment of endothelial function, a key initial event in the setting of atherosclerosis and CVD, is recurrently observed in hyperhomocysteinemia (HHcy). Read More

Open Med (Wars) 2019 16;14:66-74. Epub 2019 Jan 16.

Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.

Lower intraluminal colonic pH is an indication for the development of inflammatory bowel disease including active ulcerative colitis. Involvement of intestinal sulfate-reducing bacteria in decreasing bowel pH by the production of HS and acetate as well as their sensitivity has never been reported before. The study of the relative pH and survival of Vib-7 by monitoring sulfate reduction parameters was the aim of this work. Read More

Talanta 2019 May 26;197:1-11. Epub 2018 Dec 26.

School of Chemistry and Chemical Engineering, Shanxi University, 92 Wucheng Road, Taiyuan, PR China. Electronic address:

In this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA-AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and low toxicity. Based on these superior properties, the AuNCs have been multi-talented applied in cell imaging, hydrogen sulfide detection and pH sensing. Read More

J Comp Physiol B 2019 Feb 4. Epub 2019 Feb 4.

Department of Integrative Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada.

We investigated amphibious behaviour, hydrogen sulphide (HS) tolerance, and the mechanism of HS toxicity in the amphibious mangrove rivulus (Kryptolebias marmoratus). We found that fish emersed (left water) in response to acutely elevated [HS] (~ 130-200 µmol l). The emersion response to HS may be influenced by prior acclimation history due to acclimation-induced alterations in gill morphology and/or the density and size of neuroepithelial cells (NECs) on the gills and skin. Read More

Arch Microbiol 2019 Feb 1. Epub 2019 Feb 1.

Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.

Sulfate-reducing bacteria (SRB) belonging to the intestinal microbiota are the main producers of hydrogen sulfide and their increasing amount due to the accumulation of this compound in the bowel are involved in the initiation and maintenance of inflammatory bowel disease. The purpose of this experiment is to study the relative toxicity of hydrogen sulfide and survival of Desulfovibrio piger Vib-7 through monitoring: sulfate reduction parameters (sulfate consumption, hydrogen sulfide production, lactate consumption and acetate production) and kinetic parameters of these processes. The research is highlighting the survival of intestinal SRB, D. Read More

J Hazard Mater 2019 Jan 22;368:243-254. Epub 2019 Jan 22.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Hydrogen sulfide (HS) is well known to cause irritation and damage to airway following inhalation, but the mechanism by which HS contributes to airway toxicity is unclear. In order to assess the respiratory toxicity of HS inhalation in chicken trachea, we investigated the change of oxidative stress parameters, tracheal tissue structure and transcriptome profiles of chicken trachea exposed to HS for 42 days. The results showed HS exposure induced oxidative stress and inflammation in trachea. Read More

Chemosphere 2019 Mar 11;219:1014-1023. Epub 2018 Dec 11.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Algal blooms decay affects the mobility, bioavailability, and toxicity of arsenic (As) in aquatic environments. The decaying process alters aquatic redox conditions and also introduces ample organic matter, conditions favorable for microbial reduction to simulate As release and As species transformation. This study investigated the role of algae (Microcystis aeruginosa (MA)) blooms decay on the dynamics of labile As and elements associated with its release, such as iron (Fe), manganese (Mn) and sulfide (S), at the sediment-water surface (SWI) of a shallow lake (Lake Taihu) in China, applying mesocosm incubation. Read More

ACS Chem Biol 2019 Feb 17;14(2):170-175. Epub 2019 Jan 17.

Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology , University of Oregon , Eugene , Oregon 97403 , United States.

Hydrogen sulfide (HS) is an important gasotransmitter and biomolecule, and many synthetic small-molecule HS donors have been developed for HS-related research. One important class of triggerable HS donors is self-immolative thiocarbamates, which function by releasing carbonyl sulfide (COS), which is rapidly converted to HS by the ubiquitous enzyme carbonic anhydrase (CA). Prior studies of esterase-triggered thiocarbamate donors reported significant inhibition of mitochondrial bioenergetics and toxicity when compared to direct sulfide donors, suggesting that COS may function differently than HS. Read More

Ann Plast Surg 2019 Jan 9. Epub 2019 Jan 9.

University of Pittsburgh Medical Center, Pittsburgh, PA.

Introduction: Vascularized composite allotransplantation can reconstruct devastating tissue loss by replacing like-with-like tissues, most commonly in the form of hand or face transplantation. Unresolved technical and ethical challenges have meant that such transplants remain experimental treatments. The most significant barrier to expansion of this field is the requirement for systemic immunosuppression, its toxicity and effect on longevity. Read More

Talanta 2019 Apr 10;195:850-856. Epub 2018 Dec 10.

Department of Pharmacology, Department of Medicinal Chemistry, Qingdao University School of Pharmacy, Qingdao 266021, China. Electronic address:

Hydrogen sulfide or HS is known as an important gasotransmitter involved in regulation of many physiological and pathological processes. Since a small amount of HS is produced by endogenous cells in the body and microorganisms in the gastrointestinal tract (GI tract), the current detection probes are limited for their use in measurement of unpretentious change of HS level both in vitro and in vivo. Therefore, development of a highly sensitive and responsive fluorescent probe for measurement of HS in vivo is of great significance for investigation of HS function and toxicity. Read More

Mikrochim Acta 2019 01 7;186(2):58. Epub 2019 Jan 7.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.

The authors describe a fluorometric strategy for the determination of dopamine (DA). It is based on the use of aptamer-functionalized MoS quantum dots (QDs) and MoS nanosheets (NSs). The QDs and NSs were extensively characterized with regard to their physical and chemical properties using methods such as TEM, XRD, FT-IR, EDX and molecular spectroscopies. Read More

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Department of Biology, Faculty of Science and Literature, Kutahya Dumlupinar University, Kutahya, Turkey.

Introduction And Aim: Hydrogen sulfide (HS) is an endogenously produced gas-structure mediator. It is proposed to have antioxidant, anti-inflammatory and antiapoptotic effects. Acetaminophen (N-acetyl-P-aminophenol; APAP) is an antipyretic and analgesic medication known as paracetamol. Read More

Ecotoxicol Environ Saf 2019 Mar 29;169:778-785. Epub 2018 Nov 29.

Colleges of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong Province, China. Electronic address:

Metal pyrithiones (MePTs) are frequently used antifouling biocides in marine coatings. Their main degradation product, 2,2'-dithiobis-pyridine ((PS)), has been widely detected in seawater and may pose potential ecological risks. In the present study, sexually mature guppies (Poecilia reticulata) were exposed to (PS) at concentrations of 0, 20, 200, and 2000 ng/L for 28 days to investigate its reproductive toxicity. Read More

Toxicol Sci 2018 Dec 24. Epub 2018 Dec 24.

Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA.

Exposure to toxic levels of hydrogen sulfide (H2S) produces an acute cardiac depression that can be rapidly fatal. We sought to characterize the time course of the cardiac effects produced by the toxicity of H2S in sheep, a human sized mammal, and to describe the in vivo and in vitro antidotal properties of methylene blue (MB), which has shown efficacy in sulfide intoxicated rats. Infusing NaHS (720 mg) in anesthetized adult sheep produced a rapid dilation of the left ventricular with a decrease in contractility, which was lethal within about 10 minutes by pulseless electrical activity. Read More

J Agric Food Chem 2018 Dec 20. Epub 2018 Dec 20.

School of Agronomy , Anhui Agricultural University , Hefei 230036 , People's Republic of China.

The association between hydrogen sulfide (HS) and cell wall composition with regard to the mitigation of cadmium (Cd) toxicity in Brassica napus L. was investigated. Cd caused growth retardation, leaf chlorosis, and decreased endogenous HS content in Brassica napus roots. Read More

Methods Appl Fluoresc 2018 Dec 17;7(1):014002. Epub 2018 Dec 17.

State Key Laboratory of Chemo/Bio-sensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.

Hydrogen sulfide is an important gasotransmitter that exhibits various functions in physiological processes. We present a ratiometric fluorescence probe (SN-N) for HS by functionalizing naphthalene imide with 4-(azidomethyl)benzene as a HS recognition moiety and morpholine moiety as a lysosomal targeting unit. After reaction with HS, the azido moiety is reduced to amine group, and the probe releases the self-immolative linker and regenerates the fluorophore with internal charge transfer effect. Read More

Neurobiol Dis 2018 Nov 20. Epub 2018 Nov 20.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States.

This special issue will describe cutting-edge translational research on the development of safe and effective therapeutics for treating exposure to toxic chemical threat agents that target the nervous system. These studies are supported by the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program. Chemical threats include chemical warfare agents, pesticides and other toxic chemicals whose primary mode of action is targeted within the nervous system. Read More

Nanoscale 2018 Dec 22;10(47):22252-22262. Epub 2018 Nov 22.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.

Nano-drug delivery systems with multi-modality imaging capacities are worth pursuing because they integrate diagnostic and therapeutic functions. Herein, we report the design, synthesis and evaluation of modified iridium sulfide (IrS) nanoparticles (NPs) for cancer therapy in vitro and in vivo. This nanosystem was prepared by modifying IrS with polyethylene glycol (PEG) conjugated to the targeting ligand folate (FA) for multimodal imaging-guided combined chemo-photothermal therapy. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Mar 15;210:212-221. Epub 2018 Nov 15.

Atmospheric Environment & Air Quality Management Lab, Department of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, South Korea.

Herein, a facile one-pot synthetic method was explored for the fabrication of glutathione capped Mn doped‑zinc sulphide quantum dots (GSH-Mn-ZnS QDs) for both fluorescent detection of Cu and Hg ions and for fluorescence imaging of two cancer (RIN5F and MDAMB231) and fungal (Rhizopus oryzae) cells. Particularly, doping of Mn into ZnS QDs nanocrystal structure resulted a great improvement in the fluorescence properties of ZnS QDs. The emission peak of undoped ZnS QDs was found at 447 nm, which is due to the large number of surface defects in the ZnS QDs nanostructures. Read More

J Mol Neurosci 2019 Jan 19;67(1):133-141. Epub 2018 Nov 19.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Methamphetamine (METH) known as a highly neurotoxic compound associated with irreversible brain cell damage that results in neurological and psychiatric abnormalities. The mechanisms of METH intoxication mainly involve intraneuronal events including oxidative stress, excitotoxicity, and dopamine oxidation. Based on recent studies, HS can protect neurons through anti-inflammatory, antioxidant, and antiapoptotic mechanisms. Read More

Clin Toxicol (Phila) 2018 Nov 15:1-8. Epub 2018 Nov 15.

b Department of Emergency Medicine , University of Colorado, School of Medicine , Aurora , CO , USA.

Introduction: Hydrogen sulfide (HS) is found in petroleum, natural gas, and decaying organic matter. Terrorist groups have attempted to use it in enclosed spaces as a chemical weapon. Mass casualty scenarios have occurred from industrial accidents and release from oil field sites. Read More

Eur J Med Chem 2019 Jan 23;161:594-606. Epub 2018 Oct 23.

Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, 92618, United States. Electronic address:

Myocardial toxicity and drug resistance caused by drug efflux are major limitations of doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to develop conjugates with an improved biological profile, such as antiproliferative activity and higher cellular retention. Thus, Dox thiol conjugates, Dox thiol (Dox-SH), thiol-reactive Dox-SS-pyridine (SS = disulfide), and a Dox-SS-cell-penetrating cyclic peptide, Dox-SS-[C(WR)K], were synthesized. Read More

Biometals 2019 Feb 1;32(1):1-9. Epub 2018 Nov 1.

College of Agronomy, Guangxi University, Nanning, 530004, China.

As gasotransmitter, nitric oxide (NO) and hydrogen sulfide (HS) are involved in the regulation of plant tolerance to abiotic stresses. Aluminum (Al) toxicity triggers synthesis of NO and HS and seriously affects plant growth and productivity. Exogenous NO and HS alleviate Al toxicity in plants. Read More

J Nanobiotechnology 2018 Oct 27;16(1):83. Epub 2018 Oct 27.

Department of Medical Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, China.

Background: In order to explore the possibility of treating breast cancer by local photo-therapy, a photothermal agents loaded in situ hydrogel was established. In detail, The CuMnS nanoplates were prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as the hydrogel matrix. The CuMnS nanoplates and the hydrogel were characterized by morphous, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation as well as the rheology features. Read More

Ecotoxicology 2018 Dec 11;27(10):1303-1309. Epub 2018 Oct 11.

Research Center for Health and Environmental Risk, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan.

The commercial use of metals such as copper, lead, and zinc has markedly increased in recent years, resulting in increased interest in deep-sea mining of seafloor hydrothermal sulfide deposits. However, the full extent of the impact of deep-sea mining at hydrothermal field deposits on the environment remains unclear. In addition to impacting the deep sea, the leaching of heavy metals from extracted sulfide mineral may also affect the upper ocean zones as the sulfide rock is retrieved from the seafloor. Read More

Eur J Med Chem 2018 Nov 4;159:339-356. Epub 2018 Oct 4.

School of Stomatology of Lanzhou University; Lanzhou, 730000, China.

A series of HSCO dual-donors [Mn(CO)CSNRR] was synthesized, and evaluated from toxicity and bioactivity. The COHS measuring test showed all the complexes not only released CO, but released HS. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A-A had almost no activities against all five tumor cell lines and W138 cell line proliferation. Read More

Org Biomol Chem 2018 Oct;16(42):7903-7909

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur-721302, West Bengal, India.

Hydrogen sulfide (H2S) behaves like a two-edged sword, at low concentrations it has beneficial and cytoprotective effects, while at higher concentrations it exhibits toxicity. Hence there is a keen interest in developing light responsive H2S donors with a spatio-temporal controlled release. Herein, we report visible light activatable tetraphenylethylene conjugated p-hydroxyphenacyl (TPE-pHP-H2S) nanoparticles for the release of hydrogen sulfide (H2S) with a real time monitoring ability. Read More

Aquat Toxicol 2018 Nov 20;204:180-189. Epub 2018 Sep 20.

Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China. Electronic address:

Sulfide-quinone oxidoreductase (SQR) is a key enzyme of sulfide metabolism in metazoans, and responsible for oxidizing sulfide into thiosulfate and transmitting the generated electrons to the ubiquinone. It has been revealed that the sqr mRNA level increases significantly in echiuran worm Urechis unicinctus exposed to sulfide, and HSF1, NF1 and Sp1 have been verified to participate in its transcriptional regulation. In this study, we obtained 23 potential transcription factors interacting possibly with the proximal region (-391 to +50) of sqr promoter, and focused on the RWD domain-containing 1 (Rwdd1), a protein with the maximum number of clones in yeast one-hybrid (Y1H) screening, to investigate its transcriptional regulation to U. Read More

Nat Commun 2018 10 1;9(1):4009. Epub 2018 Oct 1.

Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.

Photocatalytic hydrogen evolution is a promising technique for the direct conversion of solar energy into chemical fuels. Colloidal quantum dots with tunable band gap and versatile surface properties remain among the most prominent targets in photocatalysis despite their frequent toxicity, which is detrimental for environmentally friendly technological implementations. In the present work, all-inorganic sulfide-capped InP and InP/ZnS quantum dots are introduced as competitive and far less toxic alternatives for photocatalytic hydrogen evolution in aqueous solution, reaching turnover numbers up to 128,000 based on quantum dots with a maximum internal quantum yield of 31%. Read More

Chemosphere 2019 Jan 6;214:25-34. Epub 2018 Sep 6.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Hydrogen sulfide (HS) is generally recognized as a highly poisonous environmental and industrial pollutant. Previous toxicological studies of HS are mainly focused on the nervous and cardiovascular system. There are few reports on the HS toxicity effects on jejunum to our knowledge. Read More

Biochim Biophys Acta Mol Basis Dis 2018 11 7;1864(11):3723-3738. Epub 2018 Sep 7.

Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, China; Hebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, Shijiazhuang, Hebei 050000, China; Key Laboratory of Vascular Medicine of Hebei Province, Shijiazhuang, Hebei 050000, China. Electronic address:

Dysfunctional vascular smooth muscle (VSM) plays a vital role in the process of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Alpha-lipoic acid (ALA) can prevent the altered VSM induced by diabetes. However, the precise mechanism underlying the beneficial effect of ALA is not well understood. Read More

Biochim Biophys Acta Mol Basis Dis 2018 11 18;1864(11):3595-3604. Epub 2018 Aug 18.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Cysteine (Cys) residues are major causes of crystallin disulfide formation and aggregation in aging and cataractous human lenses. We recently found that disulfide linkages are highly and partly conserved in β- and γ-crystallins, respectively, in human age-related nuclear cataract and glutathione depleted LEGSKO mouse lenses, and could be mimicked by in vitro oxidation. Here we determined which Cys residues are involved in disulfide-mediated crosslinking of recombinant human γD-crystallin (hγD). Read More

Analyst 2018 Oct;143(20):4844-4848

Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.

Stimulated Raman Scattering (SRS) coupled with alkyne tags has been an emerging imaging technique to visualize small-molecule species with high sensitivity and specificity. Here we describe the development of a ratiometric Raman probe for visualizing hydrogen sulfide (H2S) species in living cells as the first alkyne-based sensor for SRS microscopy. This probe uses an azide unit as a selective reactive site, and it targets mitochondria with high specificity. Read More

J Nanobiotechnology 2018 Sep 22;16(1):74. Epub 2018 Sep 22.

Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan RD, Shanghai, 200240, China.

With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed by redox-responsive delivery can be much stable when in circulation. In addition, redox-responsive vectors can respond to the high intracellular level of glutathione and release the loaded cargoes rapidly, only if they reach the site of tumor tissue or targeted cells. Read More

Regul Toxicol Pharmacol 2018 Nov 18;99:159-167. Epub 2018 Sep 18.

Chemistry Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India.

Diselenodipropionic acid (DSePA), a pharmacologically important derivative of selenocystine was evaluated for acute toxicity, mutagenic safety and metabolic stability. The estimated median oral lethal dose (LD) cut-off of DSePA in mice and rat models was ∼200 mg/kg and ∼25 mg/kg respectively, which is considerably higher than the reported oral LD dose of its parent compound. Subsequently DSePA treatment in absence and presence of rat liver S9 fraction was found to be non-mutagenic at the tested doses up to 1 mM in rifampicin resistance assay and up to 6 mM in Ames test. Read More

Nano Lett 2018 10 24;18(10):6411-6416. Epub 2018 Sep 24.

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai 200237 , China.

Near-infrared (NIR)-II fluorescence agents hold great promise for deep-tissue photothermal therapy (PTT) of cancers, which nevertheless remains restricted by the inherent nonspecificity and toxicity of PTT. In response to this challenge, we herein develop a hydrogen sulfide (HS)-activatable nanostructured photothermal agent (Nano-PT) for site-specific NIR-II fluorescence-guided PTT of colorectal cancer (CRC). Our in vivo studies reveal that this theranostic Nano-PT probe is specifically activated in HS-rich CRC tissues, whereas it is nonfunctional in normal tissues. Read More

Antioxid Redox Signal 2018 Nov 1. Epub 2018 Nov 1.

CV Center of Excellence, Louisiana State University Health Sciences Center , New Orleans, Louisiana.

Dr. Hideo Kimura is recognized as a redox pioneer because he has published an article in the field of antioxidant and redox biology that has been cited >1000 times, and 29 articles that have been cited >100 times. Since the first description of hydrogen sulfide (HS) as a toxic gas 300 years ago, most studies have been devoted to its toxicity. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jan 13;207:150-155. Epub 2018 Sep 13.

Institute of Environmental Science, Shanxi University, Taiyuan 030006, China. Electronic address:

Hydrogen sulfide (HS) can undergo dual nucleophilic reaction, which is a wise and effective way to distinguish biothiols and HS. A novel HS fluorescence probe, 4-{2-[4-(2-disulfide pyridyl-benzoyloxy)-phenyl]-vinyl}-1-methyl-pyridinium[e]iodide (DSPBP), with two nucleophilic reaction sites has been developed. The spectra results showed that DSPBP could detect HS in ratiometric and colorimetric signals and has excellent selectivity and sensitivity. Read More

Pathol Res Pract 2018 Nov 16;214(11):1804-1810. Epub 2018 Aug 16.

Department of Thoracic Surgery, Changhai Hospital, Shanghai 200435, China. Electronic address:

The protective effect of hydrogen sulfide (HS) against hypoxia-induced injury via anti-apoptosis is well established, but the underlying mechanism remains unclear. The present study aimed to investigate whether miR-455 participated in the HS protection of lung epithelial cells against CoCl-induced apoptosis by regulating endoplasmic reticulum stress (ERS)-related genes. Human lung epithelial cells BEAS-2B were subjected to hypoxia injury with or without HS preconditioning. Read More

Environ Sci Process Impacts 2018 Sep;20(9):1285-1296

Environmental Futures Research Institute, School of Environment and Science, Griffith University, Gold Coast, Queensland 4215, Australia.

In undisturbed, metal-contaminated marine sediments, porewater metal concentrations are generally low due to their associations with strong binding phases such as organic matter, Fe/Mn (oxy)hydroxides and sulfides. Bioturbating fauna can alter redox conditions and, therefore, metal binding, potentially leading to increased metal bioavailability and subsequent toxicity to inhabiting organisms. Here we assessed the impacts of bioturbation (by bivalves and large amphipod species) on sediment biogeochemistry, metal bioaccumulation and toxicity to a smaller amphipod species in a metal contaminated sediment with low and high acid volatile sulfide (AVS) concentrations. Read More

J Enzyme Inhib Med Chem 2018 Dec;33(1):1392-1404

b Department of Pharmaceutical Sciences , Università degli Studi di Milano , Milan , Italy.

The synthesis of a new dithiolethione-cysteine ethyl ester hybrid, ACS94, its metabolites, and its effect on GSH levels in rat tissues and on the concentration of circulating HS is described. ACS94 rapidly enters the cells, where it is metabolised to cysteine and the dithiolethione moiety ACS48. Experiments performed through the oral administration of ACS94 to healthy rats showed that it is capable of increasing the GSH levels in most of the analysed organs and the concentration of circulating HS. Read More

Plant Physiol Biochem 2018 Nov 24;132:46-53. Epub 2018 Aug 24.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, 700016, West Bengal, India. Electronic address:

Hydrogen sulphide (HS) is recognized as the third endogenous gasotransmitter in plants after nitric oxide (NO) and carbon monoxide (CO). Though initially visualized as a toxic gaseous molecule, recent studies have illustrated its diverse role in regulating plant growth and developmental physiology. HS is also a potent inducer of osmolytes and cellular antioxidants of enzymatic and non-enzymatic origins. Read More

Langmuir 2018 09 12;34(38):11534-11543. Epub 2018 Sep 12.

Dipartimento di Scienze Chimiche , Università degli Studi di Padova , via Marzolo 1 , 35131 Padova , Italy.

Zinc sulfide (ZnS) nanoparticles (NPs) are particularly interesting materials for their electronic and luminescent properties. Unfortunately, their robust and stable functionalization and stabilization, especially in aqueous media, has represented a challenging and not yet completely accomplished task. In this work, we report the synthesis of colloidally stable, photoluminescent and biocompatible core-polymer shell ZnS and ZnS:Tb NPs by employing a water-in-oil miniemulsion (ME) process combined with surface functionalization via catechol-bearing poly-2-methyl-2-oxazoline (PMOXA) of various molar masses. Read More

Chemosphere 2018 Dec 24;212:540-547. Epub 2018 Aug 24.

Shanghai Collaborative Innovation Centre for WEEE Recycling, Shanghai Polytechnic University, Shanghai 201209, China; Research Center of Resource Recycling Science and Engineering, Shanghai Polytechnic University, Shanghai 201209, China.

In this research, mechanochemical reduction was carried out to remediate Cr(VI) contaminated soil, and the reduction effectiveness was evaluated by analyzing the corresponding leachable fraction obtained through the toxicity characteristic leaching procedure (TCLP) proposed by the EPA. The results indicated that mechanochemical reduction can efficiently reduce the Cr(VI) concentration in the leachate. Under a milling time of 2 h, milling speed of 500 rpm, ball-to-powder weight ratio of 14 and NaS dosage of 5%, the Cr(VI) leaching concentration significantly decreased from 663. Read More

Toxicol Lett 2018 Dec 27;299:11-20. Epub 2018 Aug 27.

Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany. Electronic address:

A method is described allowing forensic analysis of plasma samples to prove human poisoning with the organophosphorus pesticides omethoate (OM) and dimethoate (DIM). Upon incubation of human serum albumin (HSA) with both pesticides tyrosine residues were phosphorylated. In addition, a novel disulfide-adduct between the identical thiol-containing leaving group of OM and DIM (2-mercapto-N-methylacetamide, MNMA) and the only free cysteine residue in HSA (Cys) was formed. Read More

Nanoscale 2018 Sep;10(35):16765-16774

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.

Developing a biocompatible nanotheranostic platform integrating diagnostic and therapeutic functions is a great prospect for cancer treatment. However, it is still a great challenge to synthesize nanotheranostic agents using an ultra-facile method. In the research reported here, ultrasmall polyethylenimine-protected silver bismuth sulfide (PEI-AgBiS2) nanodots were successfully synthesized using an ultra-facile and environmentally friendly strategy (1 min only at room temperature), which could be described as a "rookie method". Read More

Int J Environ Res Public Health 2018 08 28;15(9). Epub 2018 Aug 28.

School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China.

Arsenic sulfide residue (ASR), a by-product from the treatment of arsenic-bearing acidic wastewater, is abundantly generated but not properly disposed of in China. The utilization of such high-content arsenic waste residue is limited by the market. The traditional methods of stabilization/solidification (S/S) by lime cement or iron salt have a large mass/volume addition, high dumping cost and secondary pollution risk. Read More

Front Microbiol 2018 26;9:1575. Epub 2018 Jul 26.

Energy Biosciences Institute, University of California, Berkeley, Berkeley, CA, United States.

Hydrogen sulfide production by sulfate reducing bacteria (SRB) is the primary cause of oil reservoir souring. Amending environments with chlorate or perchlorate [collectively denoted (per)chlorate] represents an emerging technology to prevent the onset of souring. Recent studies with perchlorate reducing bacteria (PRB) monocultures demonstrated that they have the innate capability to enzymatically oxidize sulfide, thus PRB may offer an effective means of reversing souring. Read More

Int J Environ Health Res 2019 Feb 18;29(1):60-70. Epub 2018 Aug 18.

b Laboratoire de synthèse et structure des nanomatériaux , Université de Carthage , Bizerte , Tunisie.

Synthesized Mn-doped ZnS nanoparticles, with 10% of Mn dopant, were used to investigate their environmental toxicity. Mn-doped ZnS quantum dots (QDs) stabilized by 3-mercaptopropionic acid (MPA) were synthesized in a basic aqueous solution using the nucleation doping. The optical properties and structure of the obtained Mn (10%):ZnS QDs have been characterized by X-ray diffraction, UV-vis, photoluminescence spectroscopies and transmission electron microscopy. Read More

Ecotoxicol Environ Saf 2018 Nov 14;164:201-209. Epub 2018 Aug 14.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Hydrogen sulfide (HS) is widely accepted to be a signaling molecule that exhibits some potentially beneficial therapeutic effects at physiological concentrations. At elevated levels, HS is highly toxic and has a negative effect on human health and animal welfare. Studies have shown that HS exposure induces an immune function in mice, but there are few studies of the effect of continuous HS exposure on immune organs in poultry. Read More