155,897 results match your criteria Toxicity Hydrocarbons


Ecotoxicological effects of traffic-related pollutants in roadside soils of Moscow.

Ecotoxicol Environ Saf 2019 Feb 13;172:538-546. Epub 2019 Feb 13.

Faculty of Soil Science, Lomonosov Moscow State University, bld. 1/12, Leninskie Gory, Moscow 119991, Russia.

The objective of this research is to find correlations between traffic-related contaminants in the roadside soils and their ecotoxicity. The study was conducted in Moscow in the vicinity of a highway of 125 000 vehicles per day. The topsoils (0-3 cm depth) were sampled perpendicular to the road at 1-, 6-, 10-, 18- and 50-m distances from the roadbed. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.068DOI Listing
February 2019

Environmental Aspects of the Use of Extract in Bioremediation Process.

Microorganisms 2019 Feb 5;7(2). Epub 2019 Feb 5.

Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland.

This paper analyzes the impact of saponins from English ivy leaves on the properties of environmental bacterial strains and hydrocarbon degradation ability. For this purpose, two bacterial strains, M03 and M1B, have been used in toluene, 4-chlorotoluene, and α,α,α-trifluorotoluene biodegradation supported by extract. Moreover, theeffects of ivy exposition on cell properties and extract toxicity were investigated. Read More

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http://www.mdpi.com/2076-2607/7/2/43
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http://dx.doi.org/10.3390/microorganisms7020043DOI Listing
February 2019
1 Read

Effect of oil spill on compound-specific stable carbon isotope composition of amino acid in Nitzschia closterium and Heterosigma akashiwo.

Sci Total Environ 2019 Feb 5;653:1095-1104. Epub 2018 Nov 5.

College of Environmental Science and Engineering, Dalian Maritime University, Dalian, China.

Marine microalgae, the most important primary producers in marine ecosystems, are susceptible to toxicants and usually selected as the promising organisms for chemical risk testing. The stable carbon isotope ratios (δC) of amino acids (AAs) were measured to determine if compound-specific stable isotope analysis could be used to provide insight into the toxic effects of oil spill on the marine microalgae. The water accommodated fractions (WAF) of #180 fuel oil were selected as the toxic targets with different concentrations in acute (96 h) toxic tests. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.021DOI Listing
February 2019
1 Read

Removal of polycyclic aromatic hydrocarbon (PAH)-contaminated sediments by persulfate oxidation and determination of degradation product cytotoxicity based on HepG2 and ZF4 cell lines.

Environ Sci Pollut Res Int 2019 Feb 11. Epub 2019 Feb 11.

Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.

This study evaluated the use of magnetite (FeO), carbon black (CB), and FeO-CB composites activated by persulfate (PS) at circumneutral pH to oxidize polycyclic aromatic hydrocarbons (PAHs) in marine sediments. In addition, the in vitro cytotoxic activity and apoptotic response of the obtained degradation products were investigated. Chemical analyses showed that the total PAH concentration was 26,263 ng/g for sediment samples from an industrial port area. Read More

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http://dx.doi.org/10.1007/s11356-019-04421-wDOI Listing
February 2019
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Natural and assisted dissipation of polycyclic aromatic hydrocarbons in a long-term co-contaminated soil with creosote and potentially toxic elements.

Sci Total Environ 2019 Apr 27;660:705-714. Epub 2018 Dec 27.

Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS-CSIC), Apdo. 1052, 41080 Sevilla, Spain. Electronic address:

An enhanced bioremediation strategy was applied to an industrial soil co-contaminated with Polycyclic Aromatic Hydrocarbons (PAHs) and Potentially Toxic Elements (PTEs). Hydroxypropyl-β-cyclodextrin (HPBCD) and a natural mixture of two rhamnolipids (RL) were added to increase PAHs bioavailability, and combined with a microbial consortium (MC) to biodegrade soil PAHs. Bioavailability of only six PAHs (3-, 4-ring PAHs) increased when using HPBCD, with a maximum increase about 2. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.376DOI Listing

Embryonic exposure to oxy-polycyclic aromatic hydrocarbon interfere with pancreatic β-cell development in zebrafish via altering DNA methylation and gene expression.

Sci Total Environ 2019 Apr 8;660:1602-1609. Epub 2019 Jan 8.

College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China. Electronic address:

Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of anthropogenic, persistent and very toxic PAH contaminant associated with developmental toxicity. Abnormal glucose metabolism disturbs energy balances that impair the early development of vertebrates, but the mechanisms by which maternal OPAH exposure alters glucose homeostasis in offspring are not well understood. Studies have suggested that epigenetic changes, particularly in DNA methylation, provide a memory of plastic developmental responses to the environment, leading to the generation of novel offspring phenotypes. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.476DOI Listing
April 2019
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Changes in ecotoxicity of naphthalene and alkylated naphthalenes during photodegradation in water.

Chemosphere 2019 Jan 29;222:656-664. Epub 2019 Jan 29.

Division of Environmental Science and Ecological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address:

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.153DOI Listing
January 2019
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Burden of disease for workers attributable to exposure through inhalation of PPAHs in RSPM from cooking fumes.

Environ Sci Pollut Res Int 2019 Feb 4. Epub 2019 Feb 4.

Department of Civil Engineering, Indian Institute of Technology Kanpur, 208016, Kanpur, India.

Polycyclic aromatic hydrocarbons (PAHs), some of which are classified as possible carcinogens (WHO), have been detected in cooking fumes in considerable amounts. Distribution of 24 PAHs on varying particle sizes was analyzed in cooking emission. Analysis of cooking fumes from vegetarian and non-vegetarian food was carried out separately in the kitchen of a hostel mess in IIT Kanpur during November 2012 and February 2013. Read More

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http://dx.doi.org/10.1007/s11356-019-04242-xDOI Listing
February 2019
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Characteristics, distribution, source apportionment, and potential health risk assessment of polycyclic aromatic hydrocarbons in urban street dust of Kerman metropolis, Iran.

Int J Environ Health Res 2019 Feb 4:1-18. Epub 2019 Feb 4.

b Department of Geology, College of Sciences , Shahid Bahonar University of Kerman , Kerman , Iran.

In this study, the concentrations of street dust-bound polycyclic aromatic hydrocarbons (PAHs) in Kerman metropolis as a typical arid urban area were determined to investigate the contamination, molecular composition, toxicity, and sources of PAHs. Sixteen individual PAHs on the United States Environmental Protection Agency priority list were analyzed using gas chromatography-mass spectrometry in street dust samples from 30 sites. ∑PAHs ranged between 165 and 5314. Read More

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http://dx.doi.org/10.1080/09603123.2019.1566523DOI Listing
February 2019
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Inhibition of naphthalene leaching from municipal carbonaceous waste by a magnetic organophilic clay.

J Hazard Mater 2019 Jan 26;368:578-583. Epub 2019 Jan 26.

Department of Earth and Atmospheric Sciences, University of Alberta, Edmonton, Alberta T6G 2E3, Canada.

Municipal solid waste conversion into biofuels via gasification is one of the latest technologies to divert waste from landfills. The byproduct of the process is a carbonaceous material, which is often tainted with polycyclic aromatic hydrocarbons (PAH) such as naphthalene that can leach into the environment and have toxic effects on aquatic organisms. In this paper, we present a novel method to address the issue of leachable naphthalene in a carbonaceous waste produced from a gasification process, using a magnetic sorbent. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.01.088DOI Listing
January 2019
1 Read

In vitro pulmonary and vascular effects induced by different diesel exhaust particles.

Toxicol Lett 2019 Feb 1;306:13-24. Epub 2019 Feb 1.

POLARIS Research Center, Dept. of Earth and Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 1, 20126, Milano, Italy. Electronic address:

Diesel exhaust particles (DEP) are responsible for both respiratory and cardiovascular effects. However many questions are still unravelled and the mechanisms behind the health effects induced by the exposure to ultrafine particles (UFP) need further investigations. Furthermore, different emission sources can lead to diverse biological responses. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.01.017DOI Listing
February 2019
3 Reads

Proteasome inhibition by MG-132 protects against deltamethrin-induced apoptosis in rat hippocampus.

Life Sci 2019 Mar 26;220:76-83. Epub 2019 Jan 26.

Department of Toxicology, MOE Key Laboratory of Environmental and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

Aims: Deltamethrin (DM), a type II synthetic pyrethroid insecticide, is widely used in agriculture and home pest control. The evaluation of their toxic effects is of major concern to public health. However, the molecular mechanism of DM-induced neurodegenerative disease is still far from clear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.041DOI Listing
March 2019
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Early Mechanistic Events Induced by Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells: A Role for Eicosanoid Signaling.

Toxicol Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Environmental and Occupational Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs; <206.3 g/mol) are under regulated environmental contaminants (e.g. Read More

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http://dx.doi.org/10.1093/toxsci/kfz030DOI Listing
January 2019
2 Reads

Assessing pollution and risk of polycyclic aromatic hydrocarbons in sewage sludge from wastewater treatment plants in China's top coal-producing region.

Environ Monit Assess 2019 Jan 26;191(2):102. Epub 2019 Jan 26.

Department of Geological Sciences, University of Alabama, 201 7th. Ave., Tuscaloosa, AL, 35487, USA.

Managing and disposing of sewage sludge have been a severe environmental challenge around the world. China produces hundreds of million tons of sewage sludge annually, and a better understanding of the extent and risk of the associated pollution is of critical importance for implementing environmentally safe regulations and practices. The present study examined the quantity, composition, source, and risk of polycyclic aromatic hydrocarbons (PAHs) in sewage sludge from 18 wastewater treatment plants (WWTPs) in Shaanxi, one of China's top coal-producing provinces. Read More

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http://dx.doi.org/10.1007/s10661-019-7225-6DOI Listing
January 2019
3 Reads

The drought and high wet soil condition impact on PAH (phenanthrene) toxicity towards nitrifying bacteria.

J Hazard Mater 2019 Jan 21;368:274-280. Epub 2019 Jan 21.

Institute of Soil Science and Plant Cultivation, State Research Institute (IUNG-PIB), Czartoryskich 8, 24-100, Pulawy, Poland. Electronic address:

A few previous studies showed that the low soil moisture could interact with the toxic effect of the polycyclic aromatic hydrocarbons (PAHs) towards animals (mostly invertebrates). In the present research the impact of the soil moisture in the wide range (from the drought to high moisture conditions) in three different soil materials on toxic effect of the PAH (phenanthrene) towards soil microorganisms (nitrifying bacteria activity) was evaluated. The three dry soil materials were artificially contaminated with phenanthrene (0, 1, 10, 100 and 1000 mg kg dry mass of soil) and moistened to the varied levels of the soil moisture (30% WHC (dry), 55% WHC (optimal) and 80% WHC (highly wet conditions)). Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.01.055DOI Listing
January 2019
2 Reads

Lung effects of 7- and 28-day inhalation exposure of rats to emissions from 1st and 2nd generation biodiesel fuels with and without particle filter - The FuelHealth project.

Environ Toxicol Pharmacol 2019 Jan 18;67:8-20. Epub 2019 Jan 18.

Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Norway. Electronic address:

Increased use of 1st and 2nd generation biofuels raises concerns about health effects of new emissions. We analyzed cellular and molecular lung effects in Fisher 344 rats exposed to diesel engine exhaust emissions (DEE) from a Euro 5-classified diesel engine running on B7: petrodiesel fuel containing 7% fatty acid methyl esters (FAME), or SHB20 (synthetic hydrocarbon biofuel): petrodiesel fuel containing 7% FAME and 13% hydrogenated vegetable oil. The Fisher 344 rats were exposed for 7 consecutive days (6 h/day) or 28 days (6 h/day, 5 days/week), both with and without diesel particle filter (DPF) treatment of the exhaust in whole body exposure chambers (n = 7/treatment). Read More

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http://dx.doi.org/10.1016/j.etap.2019.01.005DOI Listing
January 2019
3 Reads

Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.

BMC Vet Res 2019 Jan 24;15(1):36. Epub 2019 Jan 24.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, 14853, USA.

Background: Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. Read More

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http://dx.doi.org/10.1186/s12917-019-1780-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346515PMC
January 2019
1 Read

Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba.

Sci Total Environ 2019 Mar 2;657:926-937. Epub 2018 Dec 2.

Department of Biology, Aveiro University, Campus de Santiago, 3810-193 Aveiro, Portugal; Centre for Environmental and Marine Studies (CESAM), Campus de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In the last years the environmental presence of pharmaceuticals has gained increasing attention. Research data show that these compounds can cause toxicological effects in different species of fish, mollusks and macroinvertebrates. However, the literature is scarce in terms of ecotoxicity data especially focusing on plants as test organisms. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.002DOI Listing

Taurine protected AsO-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway.

Chem Biol Interact 2019 Feb 21;300:123-130. Epub 2019 Jan 21.

Department of Occupational and Environment Health, Dalian Medical University, 9 W Lvshun South Road, Dalian, 116044, PR China; Global Health Research Center, Dalian Medical University, 9 W Lvshun South Road, Dalian, 116044, PR China. Electronic address:

The activation of hepatic stellate cells (HSCs) is a key event in the development of hepatic fibrosis caused by arsenic. However, it is unclear how arsenic induces the activation of HSCs. In the present study, we found that arsenic trioxide (AsO) induced liver tissue damage, stimulated autophagy and HSCs activation, and increased collagen accumulation in the liver of mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183142
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http://dx.doi.org/10.1016/j.cbi.2019.01.019DOI Listing
February 2019
4 Reads

Increased ZnO nanoparticle toxicity to wheat upon co-exposure to phenanthrene.

Environ Pollut 2019 Jan 14;247:108-117. Epub 2019 Jan 14.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, Jiangsu Province, 210095, People's Republic of China. Electronic address:

Polycyclic aromatic hydrocarbons and zinc oxide nanoparticles are ubiquitous pollutants in the environment. However, little information is available about their toxicity interaction in food crops. In this study, seed germination and hydroponic experiments were conducted to assess the impact of ZnO (NPs and bulk at 250, 500 and 1000 mg L) individual and combined with phenanthrene (1 mg L) on wheat growth for 15 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183454
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http://dx.doi.org/10.1016/j.envpol.2019.01.046DOI Listing
January 2019
6 Reads

Distribution of polychlorinated biphenyls in effluent from a large municipal wastewater treatment plant: Potential for bioremediation?

J Environ Sci (China) 2019 Apr 21;78:42-52. Epub 2018 Jun 21.

University of Maryland at College Park, Department of Civil and Environmental Engineering, 1147 Glenn L. Martin Hall, College Park, MD 20742, USA. Electronic address:

This study involved an evaluation of the potential for bioremediation of polychlorinated biphenyls (PCBs) in the effluent from a large municipal wastewater treatment plant. It was focused on the presence of PCBs in two types of effluents: the continuous effluent present during dry weather conditions and the intermittently present effluent that was present during wet weather due to incoming stormwater. The annual discharge of PCBs for both types of effluent was calculated based on a five-year dataset (2011-2015). Read More

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http://dx.doi.org/10.1016/j.jes.2018.06.007DOI Listing
April 2019
2 Reads

Impact of chlorine exposure time on disinfection byproduct formation in the presence of iopamidol and natural organic matter during chloramination.

J Environ Sci (China) 2019 Apr 29;78:204-214. Epub 2018 Sep 29.

Department of Civil Engineering, University of Akron, Akron, OH 44325, USA. Electronic address:

Chloramines, in practice, are formed onsite by adding ammonia to chlorinated drinking water to achieve the required disinfection. While regulated disinfection byproducts (DBPs) are reduced during chloramine disinfection, other DBPs such as iodinated (iodo-) DBPs, that elicit greater toxicity are formed. The objective of this study was to investigate the impact of prechlorination time on the formation of both halogen-specific total organic halogen (TOX) and iodo/chlorinated (chloro-) DBPs during prechlorination/chloramination in source waters (SWs) containing iopamidol, an X-ray contrast medium. Read More

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http://dx.doi.org/10.1016/j.jes.2018.09.022DOI Listing
April 2019
1 Read
2.002 Impact Factor

Metabolic and proteomic mechanism of benzo[a]pyrene degradation by Brevibacillus brevis.

Ecotoxicol Environ Saf 2019 Jan 18;172:1-10. Epub 2019 Jan 18.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, Guangdong, China. Electronic address:

Benzo[a]pyrene (BaP) is a model compound of polycyclic aromatic hydrocarbons. The relationship between its toxicity and some target biomolecules has been investigated. To reveal the interactions of BaP biodegradation and metabolic network, BaP intermediates, proteome, carbon metabolism and ion transport were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193005
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http://dx.doi.org/10.1016/j.ecoenv.2019.01.044DOI Listing
January 2019
4 Reads

Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses.

Mar Pollut Bull 2019 Jan 17;138:49-57. Epub 2018 Nov 17.

Coastal Systems Research Group, Council for Scientific and Industrial Research (CSIR), Durban, South Africa; Nelson Mandela University, P.O. Box 77000, NMU, Port Elizabeth 6031, South Africa.

The toxic equivalences (TEQs) of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) from sediment of aquatic systems in Durban, South Africa were determined in two ways: 1) TEQs of PAHs and PCBs were determined by instrumental analyses and converted to 2,3,7,8‑tetrachlorodibenzo‑para‑dioxin equivalence (TCDDeq). 2) Bioassay equivalences (BEQs) of aryl hydrocarbon receptor (AhR) ligands were analysed using the H4IIE-luc bioassay. TEQs of PCBs ranged from below limit of detection (Read More

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http://dx.doi.org/10.1016/j.marpolbul.2018.11.019DOI Listing
January 2019
2 Reads

Assessment of the toxicity, origin, biodegradation and weathering extent of petroleum hydrocarbons in surface sediments of Pars Special Economic Energy Zone, Persian Gulf.

Mar Pollut Bull 2019 Jan 27;138:302-311. Epub 2018 Nov 27.

Dept of Environmental Engineering, Babol Noshirvani University of Technology, Babol, Iran.

During the last years, the oil and gas explorations, extractions and refineries have led to severe ecological damages into the sensitive environment of the Persian Gulf. In this study, the level of oil contamination, the source of hydrocarbons and the degree of weathering or degradation extent were investigated in the Surface Sediments of Pars Special Zone, Persian Gulf. Fifteen sediment samples were collected. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2018.11.034DOI Listing
January 2019

Modeling the toxicity of dissolved crude oil exposures to characterize the sensitivity of cod (Gadus morhua) larvae and role of individual and unresolved hydrocarbons.

Mar Pollut Bull 2019 Jan 27;138:286-294. Epub 2018 Nov 27.

ExxonMobil Petroleum and Chemical, Machelen, Belgium.

Toxicity of weathered oil was investigated using Atlantic cod (Gadus morhua) larvae. A novel exposure system was applied to differentiate effects associated with dissolved and droplet oil with and without dispersant. After a 4-day exposure and subsequent 4-day recovery period, survival and growth were determined. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2018.10.065DOI Listing
January 2019

Computational in Vitro Toxicology Uncovers Chemical Structures Impairing Mitochondrial Membrane Potential.

J Chem Inf Model 2019 Jan 30. Epub 2019 Jan 30.

Center for Environmental & Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine , University of Florida , Gainesville , Florida 32611 , United States.

Technological advances in molecular biology have enabled high-throughput screening (HTS) of large chemical libraries. These approaches have provided valuable toxicity data for many physiological responses, including mitochondrial dysfunction. While several quantitative structure-activity relationship (QSAR) models have been developed for mitochondrial dysfunction, there remains a need to identify specific chemical features associated with this response. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00433DOI Listing
January 2019

A tungsten nitride-based degradable nanoplatform for dual-modal image-guided combinatorial chemo-photothermal therapy of tumors.

Nanoscale 2019 Jan;11(4):2027-2036

Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.

An innovative tungsten-based multifunctional nanoplatform composed of polyethylene glycol (PEG)-modified tungsten nitride nanoparticles (WN NPs) is constructed for tumor treatment. The PEG-WN NPs not only possess strong near-infrared (NIR) absorbance, high photothermal conversion efficiency, and excellent photothermal stability, but also effectively inhibit tumor cells upon 808 nm laser irradiation. After coating with thiolated (2-hydroxypropyl)-β-cyclodextrin (MUA-CD) on the surface, such a nanoplatform can also be used for drug delivery (such as DOX) and presents a synergistic tumor inhibition effect both in vitro and in vivo. Read More

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http://xlink.rsc.org/?DOI=C8NR09064E
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http://dx.doi.org/10.1039/c8nr09064eDOI Listing
January 2019
5 Reads

Effective gene delivery of shBMP-9 using polyethyleneimine-based core-shell nanoparticles in an animal model of insulin resistance.

Nanoscale 2019 Jan;11(4):2008-2016

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.

Bone morphogenetic protein (BMP)-9 has been associated with insulin resistance and type 2 diabetes mellitus. However, methods for delivering exogenous BMP-9 genes in vivo are lacking. In this study, we developed a gene delivery system using polyethyleneimine (PEI)-based core-shell nanoparticles (PCNs) as gene delivery carriers, and investigated the effectiveness and safety for delivery of the shBMP-9 gene. Read More

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http://xlink.rsc.org/?DOI=C8NR08193J
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http://dx.doi.org/10.1039/c8nr08193jDOI Listing
January 2019
7 Reads
7.394 Impact Factor

Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency.

Int J Nanomedicine 2019 28;14:301-315. Epub 2018 Dec 28.

Drug Delivery Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China,

Background: To establish the combination of doxorubicin (DOX) and silybin (SLB) in oral hepatic-targeting liposomes with the goal of reducing cardiotoxic side effects and improve oral hepatoma treatment.

Methods: Distearoylphosphatidylethanolamine-polyethylene glycol-cholic acid-modified liposomes (CA-LP) were used to encapsulate DOX and SLB (CA-LP-DOX/SLB), and the hepatic targeting, efficacy against hepatoma and cardioprotective effects were evaluated by cell toxicity, scratch and apoptosis in vitro studies, and pharmacokinetics and pharmacodynamics in vivo studies.

Results: In vitro cell studies showed that CA-LP-DOX/SLB inhibited HepG2 cell proliferation and HCC97H cell migration, and protected H9c2 cells. Read More

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https://www.dovepress.com/co-delivery-doxorubicin-and-silybi
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http://dx.doi.org/10.2147/IJN.S187888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314320PMC
February 2019
7 Reads

Lung cancer risk assessment for workers exposed to polycyclic aromatic hydrocarbons in various industries.

Environ Int 2019 Mar 11;124:109-120. Epub 2019 Jan 11.

Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, EPSP team (Environment and Health Prediction of Populations), 38000 Grenoble, France; VetAgro Sup, Biomathematics and Epidemiology Unit, Veterinary Campus of Lyon, F-69280 Marcy l'Etoile, France.

Background: Millions of workers are exposed to carcinogenic polycyclic aromatic hydrocarbon (PAH) mixtures. The toxicity of PAH mixtures is variable and depends on the composition of the mixture, which is related to the emission sources. Although several indicators exist, the cancer risk estimation associated with occupational exposure to PAHs is poorly known. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183227
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http://dx.doi.org/10.1016/j.envint.2018.12.058DOI Listing
March 2019
7 Reads

Determination of toxic organic pollutants in fine particulate matter using selective pressurized liquid extraction and gas chromatography-tandem mass spectrometry.

J Chromatogr A 2019 Jan 7. Epub 2019 Jan 7.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea; Center for Chemicals Risk Assessment, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea. Electronic address:

Studies investigating toxic organic pollutants in fine dust (PM2.5), such as polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), are insufficient, despite the pollutants' potent toxicity. The objective of this study is to develop an analytical method for determining PAHs, OCPs and PCBs in ambient PM2. Read More

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http://dx.doi.org/10.1016/j.chroma.2019.01.009DOI Listing
January 2019
2 Reads

Influence of differently functionalized polystyrene microplastics on the toxic effects of P25 TiO NPs towards marine algae Chlorella sp.

Aquat Toxicol 2019 Feb 18;207:208-216. Epub 2018 Dec 18.

Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Vellore 632014, India. Electronic address:

Increased utilization of titanium dioxide nanoparticles (TiO NPs) for commercial as well as industrial purposes resulted in the accumulation of nanoparticles in the marine system. Microplastics being an emerging secondary pollutant in the marine ecosystem have an impact on the toxic effects of TiO NPs which has not been evaluated up to date. So it is important to assess the toxic effects of both these pollutants on the marine environment. Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.12.014DOI Listing
February 2019
1 Read

The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell.

Pan Afr Med J 2018 8;30:264. Epub 2018 Aug 8.

Department of Dermatology and Venerology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Introduction: Keloids characterized by fibroblast hyperproliferation and depositions of collagen which similar to cancer cells. Tagitinin C is a class of sesquiterpene lactones (SLS) was isolated from the leaves of the moon flower (Hemsley) A. Gray. Read More

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http://www.panafrican-med-journal.com/content/article/30/264
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http://dx.doi.org/10.11604/pamj.2018.30.264.9994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317294PMC
January 2019
5 Reads

Impact of traffic volumes on levels, patterns, and toxicity of polycyclic aromatic hydrocarbons in roadside soils.

Environ Sci Process Impacts 2019 Jan;21(1):174-182

School of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

Vehicular exhaust is one of the important sources of polycyclic aromatic hydrocarbons (PAHs) in urban areas, and roadside soils can be directly contaminated with PAHs released from traffic emissions. In this study, roadside soils were collected at 10 sites in Ulsan, the largest industrial city in South Korea, to investigate the relationship between the traffic volume and the contamination characteristics of PAHs. The total concentrations of 16 US EPA priority PAHs (∑16 PAHs, mean: 1079 ng g-1) and organic-matter-normalized ∑16 PAHs (mean: 224 ng g-1 OM) were positively correlated with traffic volumes (Pearson correlation, r = 0. Read More

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http://dx.doi.org/10.1039/c8em00532jDOI Listing
January 2019
1 Read

[Distribution and Risk Assessment of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Wastewater-Receiving Rivers in Beijing].

Huan Jing Ke Xue 2019 Jan;40(1):256-262

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

To analyze the pollution levels and health risk assessment of Polycyclic Aromatic Hydrocarbons (PAHs) and their derivatives (SPAHs) in five typical effluents from sewage treatment plants and receiving rivers in Beijing, the concentrations of PAHs and SPAHs in samples were measured by the combined method of solid extraction and gas chromatography-mass spectrometry. The distribution characteristics were also analyzed. At the same time, the probabilistic health risk was assessed using toxic equivalent factors. Read More

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http://dx.doi.org/10.13227/j.hjkx.201806097DOI Listing
January 2019

Spent lubricant oil-contaminated soil toxicity to Eisenia andrei before and after bioremediation.

Ecotoxicology 2019 Jan 9. Epub 2019 Jan 9.

Department of Sanitary and Environmental Engineering-DESMA, Rio de Janeiro State University-UERJ. Rua São Francisco Xavier, 524, sala 5024E, Maracanã, CEP 20550-900, Rio de Janeiro, RJ, Brazil.

Bioremediation is very efficient in biodegrading petroleum hydrocarbons. However, the decrease in these target contaminants in soils is not necessarily followed by a decrease in toxicity. The remaining contaminants can be enough to retain toxicity, while incomplete degradation of several compounds can generate sub-products, which can be even more toxic. Read More

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http://dx.doi.org/10.1007/s10646-018-02013-xDOI Listing
January 2019
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Influence of anthropogenic activities and risk assessment on protected mangrove forest using traditional and emerging molecular markers (Ceará coast, northeastern Brazil).

Sci Total Environ 2019 Mar 30;656:877-888. Epub 2018 Nov 30.

Instituto de Ciências do Mar, Universidade Federal do Ceará, Av. Abolição, 3207, 60165-081 Fortaleza, CE, Brazil. Electronic address:

Anthropogenic molecular markers were used to assess chemicals inputs and ecological risks associated from multiple sources to sediments in one of the largest tropical mangrove forests of South America, with a particular focus on lesser studied compounds resulting from rural activities. Total concentrations ranged from 23.4 to 228. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.380DOI Listing
March 2019
3 Reads

Mechanical-physicochemical properties and biocompatibility of catechin-incorporated adhesive resins.

J Appl Oral Sci 2019 Jan 7;27:e20180111. Epub 2019 Jan 7.

Universidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Departamento de Odontologia Restauradora, Grupo Acadêmico de Pesquisa Clínica, São José dos Campos, São Paulo, Brasil.

Objectives: Several anti-proteolytic dentin therapies are being exhaustively studied in an attempt to reduce dentin bond degradation and improve clinical performance and longevity of adhesive restorations. This study assessed the effect of epigallocatechin-3-gallate (EGCG) on long-term bond strength when incorporated into adhesives.

Material And Methods: Adhesive systems were formulated with EGCG concentrations of 0 wt%: (no EGCG; control); 0. Read More

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http://dx.doi.org/10.1590/1678-7757-2018-0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322639PMC
January 2019
3 Reads

Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy.

Nanoscale 2019 Jan;11(4):1710-1719

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou, 510631, China.

Microwave irradiation is a powerful non-invasive approach for treating deep-seated diseases in a clinical setting. Pulsed microwave-induced thermoacoustic cavitation allows precise cancer treatment with microwave-absorbing materials. This differs from the traditional continuous microwave-induced thermotherapy which may be harmful to off-target tissues. Read More

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http://xlink.rsc.org/?DOI=C8NR08498J
Publisher Site
http://dx.doi.org/10.1039/c8nr08498jDOI Listing
January 2019
8 Reads

Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons.

Environ Int 2019 Feb 5;123:543-557. Epub 2019 Jan 5.

Global Centre for Environmental Remediation (GCER), University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address:

The genotoxic, mutagenic and carcinogenic effects of polar polycyclic aromatic hydrocarbons (polar PAHs) are believed to surpass those of their parent PAHs; however, their environmental and human health implications have been largely unexplored. Oxygenated PAHs (oxy-PAHs) is a critical class of polar PAHs associated with carcinogenic effects without enzymatic activation. They also cause an upsurge in reactive oxygen species (ROS) in living cells. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.051DOI Listing
February 2019
1 Read

The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity.

Part Fibre Toxicol 2019 01 8;16(1). Epub 2019 Jan 8.

Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment & Health, School of Population Health and Environmental Sciences, Franklin-Wilkins Building, King's College London, London, SE1 9NH, UK.

Background: Combustion of biodiesels in place of fossil diesel (FD) has been proposed as a method of reducing transport-related toxic emissions in Europe. While biodiesel exhaust (BDE) contains fewer hydrocarbons, total particulates and carbon monoxide than FD exhaust (FDE), its high nitrogen oxide and ultrafine particle content may still promote pulmonary pathophysiologies.

Main Body: Using a complement of in vitro and in vivo studies, this review documents progress in our understanding of pulmonary responses to BDE exposure. Read More

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http://dx.doi.org/10.1186/s12989-018-0284-yDOI Listing
January 2019
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Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation.

Part Fibre Toxicol 2019 01 8;16(1). Epub 2019 Jan 8.

Department of Environmental Medicine, University of Rochester Medical Center, New York, USA.

Background: The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxylation in MWCNT skin toxicity.

Results: MWCNTs were analyzed by transmission electron microscopy, zetasizer, and x-ray photoelectron spectroscopy to fully characterize the physical properties. Read More

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http://dx.doi.org/10.1186/s12989-018-0285-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323751PMC
January 2019
2 Reads

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

Pharm Res 2019 Jan 7;36(2):33. Epub 2019 Jan 7.

Department of Pharmacy &Pharmacology, Antoni van Leeuwenhoek - Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, the Netherlands.

Purpose: Limited available data suggest that older patients are more prone to develop paclitaxel-induced toxicity than their younger peers. It remains unclear whether this is related to age-dependent pharmacokinetics (PK) of paclitaxel. Primary objective of this study was to determine the influence of older age on the PK of paclitaxel. Read More

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http://dx.doi.org/10.1007/s11095-018-2563-6DOI Listing
January 2019
2 Reads

Fluorometric dopamine assay based on an energy transfer system composed of aptamer-functionalized MoS quantum dots and MoS nanosheets.

Mikrochim Acta 2019 01 7;186(2):58. Epub 2019 Jan 7.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.

The authors describe a fluorometric strategy for the determination of dopamine (DA). It is based on the use of aptamer-functionalized MoS quantum dots (QDs) and MoS nanosheets (NSs). The QDs and NSs were extensively characterized with regard to their physical and chemical properties using methods such as TEM, XRD, FT-IR, EDX and molecular spectroscopies. Read More

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http://dx.doi.org/10.1007/s00604-018-3143-5DOI Listing
January 2019
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Cellular effects of paclitaxel-loaded iron oxide nanoparticles on breast cancer using different 2D and 3D cell culture models.

Int J Nanomedicine 2019 21;14:161-180. Epub 2018 Dec 21.

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Erlangen, Germany,

Background: Magnetic drug targeting (MDT) is an effective alternative for common drug applications, which reduces the systemic drug load and maximizes the effect of, eg, chemotherapeutics at the site of interest. After the conjugation of a magnetic carrier to a chemotherapeutic agent, the intra-arterial injection into a tumor-afferent artery in the presence of an external magnetic field ensures the accumulation of the drug within the tumor tissue.

Materials And Methods: In this study, we used superparamagnetic iron oxide nanoparticles (SPIONs) coated with lauric acid and human serum albumin as carriers for paclitaxel (SPION). Read More

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http://dx.doi.org/10.2147/IJN.S187886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306067PMC
February 2019
2 Reads

Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.

Chem Biol Interact 2019 Feb 3;300:18-26. Epub 2019 Jan 3.

Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China. Electronic address:

Chronic pancreatitis is characterized by pancreatic fibrosis, associated with excessive activation of pancreatic stellate cells (PSCs) and increased expression of transforming growth factor-β1 (TGF-β1). Recently, our studies have shown that autophagy inhibitor could inhibit PSCs activation and reduce collagen secretion. Saikosaponin d (SSd), the major active component of bupleurum falcatum (a medicinal plant), has anti-fibrosis effects in liver. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183103
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http://dx.doi.org/10.1016/j.cbi.2019.01.005DOI Listing
February 2019
5 Reads

Antioxidant and cytoprotective activities of an ancient Mediterranean citrus (Citrus lumia Risso) albedo extract: Microscopic observations and polyphenol characterization.

Food Chem 2019 May 12;279:347-355. Epub 2018 Dec 12.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.

Citrus fruits are a rich source of bio-functional compounds with various and well-proven health properties. We focused our attention on an ancient Mediterranean species, Citrus lumia Risso. The aim of this work was to investigate the polyphenol content and biological activities of C. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.11.138DOI Listing

Untargeted LC-MS based C labelling provides a full mass balance of deoxynivalenol and its degradation products formed during baking of crackers, biscuits and bread.

Food Chem 2019 May 11;279:303-311. Epub 2018 Dec 11.

Center for Analytical Chemistry, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad-Lorenz-Str. 20, 3430 Tulln, Austria; Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road, Belfast BT7 1NN, Northern Ireland, United Kingdom.

Deoxynivalenol (DON) is considered to be one of the most important contaminants in cereals and food commodities produced thereof. So far it is not clear i) to which extent DON is degraded during baking and ii) if a degradation results in reduced toxicity. We have elucidated the fate of DON during baking of crackers, biscuits and bread, which were produced from fortified dough and processed under pilot plant conditions. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.11.150DOI Listing
May 2019
1 Read

PVP-templated highly luminescent copper nanoclusters for sensing trinitrophenol and living cell imaging.

Nanoscale 2019 Jan;11(3):1286-1294

Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

Copper nanoclusters (CuNCs) exhibit susceptibility to oxidation in the subnanometer size range. In this work, a facile and green protocol is reported for the successful synthesis of water soluble CuNCs, with poly(vinylpyrrolidone) as a template and ascorbic acid as a mild reducing agent. The as-prepared CuNCs exhibit a green fluorescence and high quantum yield (QY = 44. Read More

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http://dx.doi.org/10.1039/c8nr07142jDOI Listing
January 2019
1 Read