157,143 results match your criteria Toxicity Hydrocarbons


Linking past uses of legacy SVOCs with today's indoor levels and human exposure.

Environ Int 2019 Apr 13;127:653-663. Epub 2019 Apr 13.

Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 83303 Bratislava, Slovakia.

Semivolatile organic compounds (SVOCs) emitted from consumer products, building materials, and indoor and outdoor activities can be highly persistent in indoor environments. Human exposure to and environmental contamination with polychlorinated biphenyls (PCBs) was previously reported in a region near a former PCB production facility in Slovakia. However, we found that the indoor residential PCB levels did not correlate with the distance from the facility. Read More

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http://dx.doi.org/10.1016/j.envint.2019.04.001DOI Listing
April 2019
1 Read

Allenation of Terminal Alkynes with Aldehydes and Ketones.

Acc Chem Res 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Recognition and Synthesis, Department of Chemistry , Zhejiang University , Hangzhou , 310027 Zhejiang , People's Republic of China.

So far, over 150 natural products and pharmaceuticals containing an allene moiety have been identified. During the last two decades, allenes have also been demonstrated as synthetically versatile starting materials in organic synthesis. In comparison to alkenes and alkynes, allenes are unique unsaturated hydrocarbons due to their axial chirality, which could be transformed to central chirality via chirality transfer to provide an irreplaceable entry to chiral molecules. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00023DOI Listing
April 2019
2 Reads

Abnormal methylation of spermatozoa induced by benzo(a)pyrene in rats.

Hum Exp Toxicol 2019 Apr 15:960327119836230. Epub 2019 Apr 15.

1 Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Epigenetic mutations caused by pollutants are possibly linked to many diseases. Benzo(a)pyrene (BaP) is one of the most representative air pollutants and has aroused wide concern because of its strong carcinogenicity. The reproductive toxicity induced by BaP has been identified, but little is known about the characteristics of the methylation changes induced by BaP. Read More

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http://dx.doi.org/10.1177/0960327119836230DOI Listing

An ecological microsystem to treat waste oil contaminated soil: Using phytoremediation assisted by fungi and local compost, on a mixed-contaminant site, in a cold climate.

Sci Total Environ 2019 Mar 29;672:732-742. Epub 2019 Mar 29.

Center for Northern Studies, Département de sciences biologiques, Université de Montréal, Pavillon Marie-Victorin, 90 Vincent d'Indy, Montreal, QC H2V2S9, Canada. Electronic address:

As a result of anthropization and industrialization, northern remote communities face issues of soil contamination by mixtures of organic and inorganic contaminants. Soil bioremediation in cold environments is particularly challenging because of slower degradation rates, slower production of biomass for phytoextraction of trace elements (TEs), and remoteness, which can complicate logistics and inflate costs. This study evaluated a decontamination approach integrating indigenous willows, fungi and compost in a northern community. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.447DOI Listing
March 2019
1 Read

Food risk characterization from exposure to persistent organic pollutants and metals contaminating eels from an Italian lake.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Apr 8:1-10. Epub 2019 Apr 8.

a Department of Health, Animal Science and Food Safety , University of Milan , Milan , Italy.

Monitoring environmental contaminants in edible animal species is important for the assessment of environmental quality and for food safety as well. In this study, the occurrence of 2,3,7,8 dioxins, and furans, dioxin-like polychlorinated biphenyls, six non-dioxin-like polychlorinated biphenyl indicators (ndl-PCBs), seven polybrominated diphenylethers (PBDEs), four polycyclic aromatic hydrocarbons (PAHs) and four metals (As, Hg, Ni, Pb) was evaluated in 90 European eels (Anguilla anguilla) from Lake Garda. The results on eel samples showed a frequent contamination of dl-PCBs, found at concentrations higher than the maximum limit (ML) provided by European Union in 41 % of the eels. Read More

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http://dx.doi.org/10.1080/19440049.2019.1591642DOI Listing
April 2019
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Formation of PAH Derivatives and Increased Developmental Toxicity during Steam Enhanced Extraction Remediation of Creosote Contaminated Superfund Soil.

Environ Sci Technol 2019 Apr 8;53(8):4460-4469. Epub 2019 Apr 8.

Department of Environmental & Molecular Toxicology , Oregon State University , Corvallis , Oregon 97331 , United States.

Steam enhanced extraction (SEE) is an in situ thermal remediation technique used to remove and recover polycyclic aromatic hydrocarbons (PAHs) from contaminated soils. However, limited studies have been conducted on the formation of PAH derivatives during and after SEE of PAH contaminated soils. Creosote contaminated soil samples collected from the Wyckoff-Eagle Harbor Superfund site were remediated with laboratory scale SEE. Read More

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http://dx.doi.org/10.1021/acs.est.8b07231DOI Listing
April 2019
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Comparative study of phytotoxicity and genotoxicity of soil contaminated with biodiesel, diesel fuel and petroleum.

Ecotoxicology 2019 Apr 5. Epub 2019 Apr 5.

Department of Biochemistry and Microbiology, São Paulo State University (UNESP) Institute of Biosciences, Av. 24A, 1515, Rio Claro, SP, 13506-900, Brazil.

The worldwide spillage of fossil fuels causes an ever-increasing environmental concern due to their resistance to biodegradation and toxicity. The diesel fuel is one of the derivative forms of petroleum that is widely used in the world. Its composition has many aromatic compounds and long hydrocarbons chains, both persistent and hazardous, thus requiring complex microbial dynamics to achieve full biodegradation. Read More

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http://dx.doi.org/10.1007/s10646-019-02037-xDOI Listing
April 2019
3 Reads

Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Trastuzumab Followed by 5-Fluorouracil/Epirubicin/Cyclophosphamide for HER2-positive Operable Breast Cancer: A Multicenter Phase II Trial.

Anticancer Res 2019 Apr;39(4):2053-2059

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Aim: This study was conducted in order to evaluate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus trastuzumab followed by 5-fluorouracil/ epirubicin/cyclophosphamide (FEC) in a neoadjuvant chemotherapy (NAC) setting for patients with human epidermal growth factor receptor 2 (HER2)-positive operable breast cancer.

Patients And Methods: Each patient received four cycles of 260 mg/m nab-paclitaxel with 6 mg/kg trastuzumab (8 mg/kg as the loading dose) every 3 weeks (q3w) followed by four cycles of FEC (500/100/500 mg/m) q3w. The primary endpoint was pathological complete response (pCR) rate. Read More

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http://dx.doi.org/10.21873/anticanres.13316DOI Listing

Chironomus riparius exposure to field-collected contaminated sediments: From subcellular effect to whole-organism response.

Sci Total Environ 2019 Mar 27;671:874-882. Epub 2019 Mar 27.

Irstea Lyon, Riverly Research Unit, Villeurbanne, France.

The toxicity of three field-collected sediments differentially contaminated with pesticides, heavy metals, phtalates and polycyclic aromatic hydrocarbons (PAHs), was assessed in Chironomus riparius. For this purpose, C. riparius larvae were exposed throughout their entire life cycle to sediments collected in three sites along the Saulx river in France, and the toxic effects were measured at different levels of biological organization: from the molecular (lipidomic analysis and transcriptional variations) to the whole organism response (respiration rate, shape markers and emergence rate). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.384DOI Listing
March 2019
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Review of Polycyclic Aromatic Hydrocarbons (PAHs) Sediment Quality Guidelines for the Protection of Benthic Life.

Integr Environ Assess Manag 2019 Apr 4. Epub 2019 Apr 4.

ExxonMobil Biomedical Sciences Inc., 22777 Springwood Village Parkway, Spring, TX, USA.

Polycyclic aromatic hydrocarbons (PAHs) in sediments can pose harm to the benthic community. Numerous sediment quality guidelines (SQGs) for the protection of benthic life are available to assess the risk of individual PAHs and PAH mixtures in sediments. SQGs are derived using empirical or mechanistic approaches. Read More

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http://dx.doi.org/10.1002/ieam.4142DOI Listing
April 2019
2 Reads

Turnover and legacy of sediment-associated PAH in a baseflow-dominated river.

Sci Total Environ 2019 Mar 21;671:754-764. Epub 2019 Mar 21.

Center for Applied Geoscience, University of Tübingen, Hölderlinstr. 12, 72074 Tübingen, Germany. Electronic address:

Polycyclic Aromatic Hydrocarbons (PAH) ubiquitously occur in rivers and threaten the aquatic ecosystem. Understanding their fate and behaviour in rivers can help in improving management strategies. We develop a particle-facilitated transport model considering suspended sediments with sorbed PAH from different origins to investigate the turnover and legacy of sediment-bound PAH in the baseflow-dominated Ammer River in southwest Germany. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.236DOI Listing
March 2019
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Applicability of in vitro methods in evaluating the biotransformation of polycyclic aromatic hydrocarbons (PAHs) in fish: Advances and challenges.

Sci Total Environ 2019 Mar 27;671:685-695. Epub 2019 Mar 27.

Department of Environmental Science, Baylor University, Waco, TX 76706, USA.

The biotransformation of polycyclic aromatic hydrocarbons (PAHs) and the biochemical mechanisms involved in such process continue to be intensively studied in the fields of environmental science and toxicology. The investigation of PAH biotransformation in fish is fundamental to understand how piscine species cope with PAH exposure, as these compounds are ubiquitous in aquatic ecosystems and impact different levels of biological organization. New approaches are continuously developed in the field of ecotoxicology, allowing live animal testing to be combined with and, in some cases, replaced with novel in vitro systems. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.394DOI Listing
March 2019
2 Reads
4.099 Impact Factor

Analysis of sublethal toxicity in developing zebrafish embryos exposed to a range of petroleum substances.

Environ Toxicol Chem 2019 Mar 28. Epub 2019 Mar 28.

ExxonMobil Biomedical Science, Inc, Annandale, NJ, USA.

The OECD 236 Fish Embryo Acute Toxicity Test guideline relies on 4 endpoints to describe exposure related effects (coagulation, lack of somite formation, tail-bud detachment from yolk-sac, and presence of heartbeat). Danio rerio (zebrafish) embryos were used to investigate these endpoints along with a number of additional sublethal effects (i.e. Read More

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http://dx.doi.org/10.1002/etc.4428DOI Listing
March 2019
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An integrative assessment to determine the sediment toxicity of Kaohsiung Harbor in Taiwan: combining chemical analysis and cytotoxicity assay.

Environ Sci Pollut Res Int 2019 Mar 27. Epub 2019 Mar 27.

Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, 81157, Taiwan.

To evaluate the toxicity of sediments collected from the mouths of four  rivers and entrances of Kaohsiung Harbor, Taiwan, a combination of in vitro cytotoxicity assays (Clone 9 cells) and chemical analysis that quantified 16 polycyclic aromatic hydrocarbons (PAHs), 10 phthalate esters (PAEs), and 2 alkylphenols (APs) was employed. Results showed that the total concentrations of PAHs, PAEs, and APs ranged between 77.9 and 24,363 ng/g dw, between 268 and 118,010 ng/g dw, and between 32. Read More

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http://link.springer.com/10.1007/s11356-019-04840-9
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http://dx.doi.org/10.1007/s11356-019-04840-9DOI Listing
March 2019
3 Reads

Influence of emulsified biodiesel on the emission and health risk of polycyclic aromatic hydrocarbons in the vapor and particulate phases during engine combustion.

Environ Sci Pollut Res Int 2019 Mar 25. Epub 2019 Mar 25.

Institute of Environmental Engineering, National Sun Yat-sen University, Kaohsiung, 804, Taiwan.

Biofuel is a renewable energy source for transportation. Given the toxicity associated with particulate polycyclic aromatic hydrocarbons (PAHs) is not fully understood, investigating the difference of adverse health risks posed between vapor and particulate PAH emissions from biodiesel-fueled engine combustion was the objective of this study. Three different fuel types, including typical diesel, emulsified diesel with a water fraction from 10 to 19% (v/v), and emulsified biodiesel with water (10%) and biofuel fractions from 10 to 40% (v/v), were studied. Read More

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http://dx.doi.org/10.1007/s11356-019-04805-yDOI Listing
March 2019
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Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress.

Oxid Med Cell Longev 2019 17;2019:8936856. Epub 2019 Feb 17.

Department of Urology, The First Hospital of Jilin University, Changchun, 130021 Jilin, China.

The best treatment for end-stage renal disease is renal transplantation. However, it is often difficult to maintain a renal allograft healthy for a long time following transplantation. Interstitial fibrosis and tubular atrophy (IF/TA) are significant histopathologic characteristics of a compromised renal allograft. Read More

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http://dx.doi.org/10.1155/2019/8936856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397988PMC

Potential use of endophytic root bacteria and host plants to degrade hydrocarbons.

Int J Phytoremediation 2019 Mar 25:1-11. Epub 2019 Mar 25.

c Department of Soil Science , University of Saskatchewan , Saskatoon , Canada.

Microbe-assisted phytoremediation depends on competent root-associated microorganisms that enhance remediation efficiency of organic compounds. Endophytic bacteria are a key element of the root microbiome and may assist plant degradation of contaminants. The aim of this study was to investigate the application of four hydrocarbon-degrading endophytic strains previously isolated from an oil sands reclamation area. Read More

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http://dx.doi.org/10.1080/15226514.2019.1583637DOI Listing
March 2019
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PM- and PM-bound polycyclic aromatic hydrocarbons (PAHs) in the residential area near coal-fired power and steelmaking plants of Taichung City, Taiwan: In vitro-based health risk and source identification.

Sci Total Environ 2019 Mar 15;670:439-447. Epub 2019 Mar 15.

National Institute of Environmental Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli 35053, Taiwan; Department of Occupational Safety and Health, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. Electronic address:

We investigated spatial and season variations in particle-bound PAH concentrations, identified their potential sources and estimated resultant health risk of activate toxicity pathways in a residential area near coal-fired power and steelmaking plants. Both atmospheric PM and PM samples (n = 94) were simultaneously collected for summer and winter in the Wuqi and Shalu districts of Taichung City, central Taiwan. The principal component analysis (PCA) measure was used to evaluate the sources of particle-bound PAHs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.198DOI Listing
March 2019
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Response of the native springtail Parisotoma insularis to diesel fuel contaminated soils under field-realistic exposure conditions at subantarctic Macquarie Island.

Integr Environ Assess Manag 2019 Mar 22. Epub 2019 Mar 22.

Australian Antarctic Division, Department of the Environment and Energy, Australian Government, Kingston, TAS, Australia.

A number of sites contaminated by petroleum hydrocarbons from past fuel spills are currently undergoing remediation on subantarctic Macquarie Island. To assess the environmental risks these pose, and to establish remediation targets and guideline values, toxicity data for a range of native biota are required. The availability of data for local biota is limited, especially for soil invertebrates, which are critical to soil health. Read More

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http://dx.doi.org/10.1002/ieam.4148DOI Listing
March 2019
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Ecotoxicity of NSO-heterocycles (NSO-HET) and short-chained alkyl phenols (SCAP) commonly detected in contaminated groundwater.

Environ Toxicol Chem 2019 Mar 22. Epub 2019 Mar 22.

Department of Ecosystem Analysis, , Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.

Heterocyclic aromatic hydrocarbons (NSO-HET) and short-chained alkyl phenols (SCAP) are commonly detected in groundwater at contaminated sites and in the surrounding environment. It is now scientific consensus that these chemicals pose a risk to human and ecosystem health. However, toxicity data are comparably fragmentary and only few studies have addressed the ecotoxicity of NSO-HET and SCAP in a systematic and comparative fashion. Read More

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http://dx.doi.org/10.1002/etc.4423DOI Listing
March 2019
2 Reads

The Recommendation and Use of Extracorporeal Membrane Oxygenation (ECMO) in Cases Reported to the California Poison Control System.

J Med Toxicol 2019 Mar 20. Epub 2019 Mar 20.

California Poison Control System (CPCS), Sacramento Division, 2450 48th St. ASB 1260, Sacramento, CA, 95817, USA.

Introduction: Antidotes are available to treat some specific poisonings; however, the mainstay of treatment for the poisoned patient remains supportive care. Extracorporeal membrane oxygenation (ECMO) is one of the most aggressive supportive measures available to manage poisoned patients.

Objective: To characterize the recommendation and use of ECMO in cases reported to the California Poison Control System (CPCS). Read More

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http://dx.doi.org/10.1007/s13181-019-00704-3DOI Listing
March 2019
1 Read

In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish.

Sci Total Environ 2019 May 14;665:995-1002. Epub 2019 Feb 14.

State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, Fujian 361005, China. Electronic address:

Although Bisphenol F (BPF), a bisphenol A (BPA) analogue with a similar chemical structure to that of BPA, is widely used in commercial products, little is known about its potential toxic effects on the reproductive neuroendocrine system in vivo. The present study aimed to comprehensively evaluate the effects of BPF on the reproductive neuroendocrine system in zebrafish and to assess the potential mechanisms underlying its association with estrogen receptor (ER) and aromatase (AROM) pathways. Long-term exposure to environmentally relevant and low levels of BPF led to increased expression of reproductive neuroendocrine-related genes (kiss1, kiss1r, gnrh3, lhβ, and fshβ) in the zebrafish brain, as well as increased levels of adrenocorticotropic, gonadotropin-releasing, luteinizing, and follicle-stimulating hormones in the zebrafish brain and vitellogenin in the zebrafish liver. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.154DOI Listing

Polyelectrolyte Carboxymethyl Cellulose for Enhanced Delivery of Doxorubicin in MCF7 Breast Cancer Cells: Toxicological Evaluations in Mice Model.

Pharm Res 2019 Mar 18;36(5):68. Epub 2019 Mar 18.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: Chemotherapy as an important tool for cancer treatment faces many obstacles such as multidrug resistance and adverse toxic effects on healthy tissues. Drug delivery systems have opened a new window to overcome these problems.

Methods: A polyelectrolyte carboxymethyl cellulose polymer as a magnetic nanocarrier was synthesized for enhancing delivery and uptake of doxorubicin in MCF7 breast cancer cells and decreasing the adverse toxic effects to healthy tissues. Read More

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http://dx.doi.org/10.1007/s11095-019-2598-3DOI Listing
March 2019
1 Read
3.420 Impact Factor

Incidental finding of non-Hodgkin's lymphoma in a patient affected by castration-sensitive prostate cancer: A case report.

Medicine (Baltimore) 2019 Mar;98(11):e14805

Department of Medical Oncology, Azienda Ospedaliero-Universitaria "A. Cardarelli", Naples.

Rationale: This article describes the case of a patient with 2 simultaneous malignant diseases: Follicular lymphoma and 'castration sensitive prostate cancer. Patients with multiple cancers are not easy to manage and it is difficult to find the appropriate approach and resources to use with them. We focused our attention on how to choose the correct strategy to face 2 different neoplasms and control the adverse reactions related to the corresponding treatments. Read More

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http://dx.doi.org/10.1097/MD.0000000000014805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426560PMC
March 2019
1 Read

Individual and combined toxicity of carboxylic acid functionalized multi-walled carbon nanotubes and benzo a pyrene in lung adenocarcinoma cells.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Co-exposure to carboxylic acid functionalized multi-walled carbon nanotubes (F-MWCNTs) and polycyclic aromatic hydrocarbons (PAHs) such as benzo a pyrene (BaP) in ambient air have been reported. Adsorption of BaP to F-MWCNTs can influence combined toxicity. Studying individual toxicity of F-MWCNTs and BaP might give unrealistic data. Read More

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http://dx.doi.org/10.1007/s11356-019-04795-xDOI Listing
March 2019
1 Read

Nrf2 protects against diverse PM components-induced mitochondrial oxidative damage in lung cells.

Sci Total Environ 2019 Jun 6;669:303-313. Epub 2019 Mar 6.

Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

Nrf2 is an important transcription factor implicated in the oxidative stress response, which has been reported to play an important role in the way by which air pollution particulate matter (PM) induces adverse health effects. This study investigates the mechanism by which Nrf2 exerts its protective effect in PM induced toxicity in lung cells. Lung cells silenced for Nrf2 (shNrf2) demonstrated diverse susceptibility to various PM extracts; water extracts containing high levels of dissolved metals exhibited higher capacity to generate mitochondrial reactive oxygen species (ROS) and hence increased oxidative stress levels. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.436DOI Listing
June 2019
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Development and validation of a bioanalytical assay based on liquid chromatography-tandem mass spectrometry for measuring biomarkers of exposure of alternative plasticizers in human urine and serum.

Talanta 2019 Jun 5;198:230-236. Epub 2019 Feb 5.

Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium. Electronic address:

Alternative plasticizers (APs) have been increasingly used in the last decade to replace conventional phthalate esters, in particular di(2-ethylhexyl) phthalate (DEHP), due to the toxicity of the latter. However, there is currently very little data about the toxicity of and exposure to APs. No method exists so far for the analysis of multiple exposure biomarkers. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.02.024DOI Listing

Chemical and Biological Components of Urban Aerosols in Africa: Current Status and Knowledge Gaps.

Int J Environ Res Public Health 2019 Mar 15;16(6). Epub 2019 Mar 15.

Institute for Applied Ecology New Zealand, School of Science, Auckland University of Technology, Auckland 1142, New Zealand.

Aerosolized particulate matter (PM) is a complex mixture that has been recognized as the greatest cause of premature human mortality in low- and middle-income countries. Its toxicity arises largely from its chemical and biological components. These include polycyclic aromatic hydrocarbons (PAHs) and their nitro-derivatives (NPAHs) as well as microorganisms. Read More

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http://dx.doi.org/10.3390/ijerph16060941DOI Listing
March 2019
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Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice.

J Agric Food Chem 2019 Apr 20;67(13):3789-3795. Epub 2019 Mar 20.

Department of Nutrition and Food Science , University of Maryland , 0112 Skinner Building , College Park , Maryland 20742 , United States.

A novel synthetic route was designed, developed, and utilized to synthesize six high-purity 2-monochloropropanediol fatty acid esters (2-MCPD esters), a group of potential processing-induced food contaminants. A chlorine atom was introduced to C-2 of a diethyl malonate molecule, which was reduced by NaBH and followed by esterification using fatty acids. The reaction products were isolated and purified using silica gel columns to obtain three 2-MCPD monoesters and three diesters at about 50-54% and 56-59% yields, respectively. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b01083
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http://dx.doi.org/10.1021/acs.jafc.9b01083DOI Listing
April 2019
7 Reads

Toxicity assessment of pollutants sorbed on environmental sample microplastics collected on beaches: Part I-adverse effects on fish cell line.

Environ Pollut 2019 Feb 20. Epub 2019 Feb 20.

Univ. Bordeaux, EPOC, UMR 5805, F-33400, Talence, France. Electronic address:

Microplastics (MPs), are tiny plastic fragments from 1 μm to 5 mm generally found in the aquatic environment which can be easily ingested by organisms and may cause chronic physical but also toxicological effects. Toxicological assays on fish cell lines are commonly used as an alternative tool to provide fast and reliable assessment of the toxic and ecotoxic properties of chemicals or mixtures. Rainbow trout liver cell line (RTLW-1) was used to evaluate the toxicity of pollutants sorbed to MPs sampled in sandy beaches from different islands around the world during the first Race for Water Odyssey in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.12.091DOI Listing
February 2019
1 Read

Effects of steroidal saponins extract from Ophiopogon japonicus root ameliorates doxorubicin-induced chronic heart failure by inhibiting oxidative stress and inflammatory response.

Pharm Biol 2019 Dec;57(1):176-183

d Department of Cardiology , The Second Affiliated Hospital of Xi'an JiaoTong University , Xian , China.

Context: Ophiopogonis Radix, the root of Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), is a Traditional Chinese Medicine, which has been investigated to possess effective treatment of cardiovascular diseases.

Objective: This study evaluates the cardioprotective effects of steroidal saponins extract from Ophiopogon japonicus (SOJ) root against doxorubicin-induced chronic heart failure (CHF) through the amelioration of oxidative stress and inflammation. Read More

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http://dx.doi.org/10.1080/13880209.2019.1577467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419681PMC
December 2019
1 Read

Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway.

Cell Mol Biol Lett 2019 26;24:17. Epub 2019 Feb 26.

3Faculty of Chinese Medical Science, Guangxi University of Chinese Medicine, No. 13 Wuhe Road, Qingxiu District, Nanning, 530222 Guangxi China.

Objective: We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO).

Materials And Methods: Rats were randomly assigned to five groups: control, ISO, ISO + propranolol (10 mg/kg), ISO + TMP (10 mg/kg) and ISO + TMP (20 mg/kg). The rats in the three ISO + groups were pretreated with propranolol or TMP, while the rats in the control and ISO groups were pretreated with an equal volume of saline. Read More

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http://dx.doi.org/10.1186/s11658-019-0141-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390582PMC
April 2019
2 Reads
1.593 Impact Factor

Enhanced effects of dietary tannic acid with chlorantraniliprole on life table parameters and nutritional physiology of Spodoptera exigua (Hübner).

Pestic Biochem Physiol 2019 Mar 29;155:108-118. Epub 2019 Jan 29.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University Wuhan, Hubei 430070, PR China. Electronic address:

The beet armyworm, Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) is a highly polyphagous pest which causes considerable economic losses to cotton and many vegetable crops. Tannins are among the most important secondary metabolites in cotton plants. We show that tannic acid enhances the toxic effect of chlorantraniliprole on S. Read More

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http://dx.doi.org/10.1016/j.pestbp.2019.01.012DOI Listing
March 2019
1 Read
2.014 Impact Factor

Seasonal and spatial variations in the chemical components and the cellular effects of particulate matter collected in Northern China.

Sci Total Environ 2018 Jun 20;627:1627-1637. Epub 2018 Feb 20.

College of Urban and Environmental Sciences, Laboratory for Earth Surface Processes, Peking University, Beijing 100871, China.

The health effects of airborne particulate matter (PM) are likely to be strongly influenced by its components. The relationship between the composition of PM and its biological effects has been investigated in vitro/vivo, but more studies are needed to achieve a better understanding of the relationship. Such studies are limited in Northern China, where severe air pollution causes significant health impacts. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.01.224DOI Listing
June 2018
1 Read

Emissions from a fast-pyrolysis bio-oil fired boiler: Comparison of health-related characteristics of emissions from bio-oil, fossil oil and wood.

Environ Pollut 2019 Mar 1;248:888-897. Epub 2019 Mar 1.

Fine Particle and Aerosol Technology Laboratory, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

There is currently great interest in replacing fossil-oil with renewable fuels in energy production. Fast pyrolysis bio-oil (FPBO) made of lignocellulosic biomass is one such alternative to replace fossil oil, such as heavy fuel oil (HFO), in energy boilers. However, it is not known how this fuel change will alter the quantity and quality of emissions affecting human health. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.086DOI Listing
March 2019
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Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate.

Toxicol Lett 2019 Jun 7;307:49-58. Epub 2019 Mar 7.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address:

Rhabdomyolysis is characterized by elevation of plasma creatine phosphokinase (CPK) level, and multiple organ disorders, especially renal failure, as well as approximately 50% of acquired rhabdomyolysis are caused by pharmaceuticals. Statins are known to cause rhabdomyolysis, and its incidence is ≥10 times higher with coadministration of statin and fibrate. The purpose of this study is to establish a mouse model of drug-induced rhabdomyolysis by coadministration of statin and fibrate to clarify the mechanisms of its myotoxicity. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.03.001DOI Listing
June 2019
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Toxicity Assessment of Impacted Sediments from Southeast Coast of Tunisia Using a Biomarker Approach with the Polychaete Hediste diversicolor.

Arch Environ Contam Toxicol 2019 May 9;76(4):678-691. Epub 2019 Mar 9.

Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.

Toxicity caused by exposure to pollutants from marine sediments is a consequence of the interaction between biota and xenobiotics most frequently released by anthropogenic activities. The present work intended to characterize the toxicity of natural sediments putatively impacted by distinct human activities, collected at several sites located in the south of the Gulf of Gabes, Zarzis area, Tunisia. The selected toxicity criteria were analysed following ecologically relevant test conditions. Read More

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http://dx.doi.org/10.1007/s00244-019-00611-2DOI Listing
May 2019
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Advancing soil ecological risk assessments for petroleum hydrocarbon contaminated soils in Canada: Persistence, organic carbon normalization and relevance of species assemblages.

Sci Total Environ 2019 Jun 1;668:400-410. Epub 2019 Mar 1.

Toxicology Group, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Soil Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Sediment toxicity studies and ecological risk assessments on organic contaminants routinely apply organic carbon normalization to toxicity data; however, no studies examine its potential for use in soils with petroleum hydrocarbon (PHC) contamination. Limited studies in soil ecotoxicology assess the influence of species assemblages used in species sensitivity distribution construction on the resulting guideline designated to of soil dwelling organisms. Canadian regulations utilize more conservative approaches to deriving guidelines with soil ecotoxicology data compared to the rest of the world, so we investigated the impact of these on soil invertebrates in a variety of field soils. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.459DOI Listing
June 2019
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The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy.

Nat Commun 2019 03 8;10(1):1125. Epub 2019 Mar 8.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Whether tobacco carcinogens enable exposed cells immune escape resulting in carcinogenesis, and why patients who smoke respond better to immunotherapies than non-smokers, remains poorly understood. Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR). Anti-PD-L1 antibody or deficiency in AhR significantly suppresses BaP-induced lung cancer. Read More

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http://dx.doi.org/10.1038/s41467-019-08887-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408580PMC
March 2019
5 Reads
10.742 Impact Factor

Preparation and Measuring of Brain GABA R-coupled Cl /HCO - Activity for Integral Assessment of Aquatic Toxicity.

Curr Protoc Toxicol 2019 Mar 7:e70. Epub 2019 Mar 7.

Institute of General Pathology and Pathological Physiology, Moscow, Russia.

The wide use of aromatic hydrocarbons in various industries is having a negative effect on the environment and human health. Therefore, a key focus of current toxicology is the development and use of protein reporters with high sensitivity to various aromatic hydrocarbons (including phenolics and drugs). One molecular target for a wide range of pharmacology drugs and aromatic hydrocarbons (including phenol) is the neuronal GABA R-coupled Cl /HCO -ATPase. Read More

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http://dx.doi.org/10.1002/cptx.70DOI Listing
March 2019
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Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation.

J Toxicol Sci 2019 ;44(3):177-189

Department of Immunology, Jiangxi Medical College, Nanchang University, China.

Recent studies have shown that sevoflurane can cause long-term neurotoxicity and learning and memory impairment in developing and progressively neurodegenerative brains. Sevoflurane is a widely used volatile anesthetic in clinical practice. Late gestation is a rapidly developing period in the fetal brain, but whether sevoflurane anesthesia during late gestation affects learning and memory of offspring is not fully elucidated. Read More

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http://dx.doi.org/10.2131/jts.44.177DOI Listing
March 2019
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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

J Toxicol Sci 2019 ;44(3):167-175

Department of Pharmacy, the First Hospital of Jilin University, China.

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered AS IV for 7 days. Histopathological and biochemical analysis were used to assess liver and kidney function. Read More

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http://dx.doi.org/10.2131/jts.44.167DOI Listing
March 2019
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Ruminal methane production: Associated microorganisms and the potential of applying hydrogen-utilizing bacteria for mitigation.

Sci Total Environ 2019 Mar 14;654:1270-1283. Epub 2018 Nov 14.

Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China; MoE Key Laboratory of Molecular Animal Nutrition, China. Electronic address:

Methane emission from ruminants not only causes serious environmental problems, but also represents a significant source of energy loss to animals. The increasing demand for sustainable animal production is driving researchers to explore proper strategies to mitigate ruminal methanogenesis. Since hydrogen is the primary substrate of ruminal methanogenesis, hydrogen metabolism and its associated microbiome in the rumen may closely relate to low- and high-methane phenotypes. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.180DOI Listing
March 2019
2 Reads

Reduced vs. standard dose native E. coli-asparaginase therapy in childhood acute lymphoblastic leukemia: long-term results of the randomized trial Moscow-Berlin 2002.

J Cancer Res Clin Oncol 2019 Apr 6;145(4):1001-1012. Epub 2019 Mar 6.

Department of Oncology, Hematology and Radiotherapy, Pirogov Russian National Research Medical University, Moscow, Russia.

Purpose: Favorable outcomes were achieved for children with acute lymphoblastic leukemia (ALL) with the first Russian multicenter trial Moscow-Berlin (ALL-MB) 91. One major component of this regimen included a total of 18 doses of weekly intramuscular (IM) native Escherichia coli-derived asparaginase (E. coli-ASP) at 10000 U/m during three consolidation courses. Read More

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http://link.springer.com/10.1007/s00432-019-02854-x
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http://dx.doi.org/10.1007/s00432-019-02854-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435612PMC
April 2019
6 Reads

[Clinical observation for NAPD regimen in the treatment of 67 cases of recurrent refractory non-Hodgkin's lymphoma].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Jan;44(1):46-52

Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objective: To explore the clinical efficacy and toxicity of the NAPD regimen(vinorelbine, cytarabine, cisplatin, and dexamethasone) in the treatment of recurrent refractory non-Hodgkin' s lymphoma.
 Methods: A total of 67 patients identified with recurrent refractory non-Hodgkin's lymphoma were enrolled for this retrospective study. The curative efficacy of NAPD regimen was evaluated after 2 consecutive cycles. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.01.008DOI Listing
January 2019
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Effect of pyrolysis conditions on the total contents of polycyclic aromatic hydrocarbons in biochars produced from organic residues: Assessment of their hazard potential.

Sci Total Environ 2019 Jun 28;667:578-585. Epub 2019 Feb 28.

Instituto de Recursos Naturales y Agrobiología de Sevilla, Consejo Superior de Investigaciones Científicas (IRNAS-CSIC), Av. Reina Mercedes 10, 41012 Seville, Spain.

The interest of using biochar, the solid byproduct from organic waste pyrolysis, as soil conditioner is significantly increasing. Nevertheless, persistent organic pollutants, such as polycyclic aromatic hydrocarbons (PAHs), are formed during pyrolysis due to the incomplete combustion of organic matter. Consequently, these pollutants may enter the environment when biochar is incorporated into soil and cause adverse ecological effects. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.421DOI Listing
June 2019
2 Reads

Antioxidant defence system is responsible for the toxicological interactions of mixtures: A case study on PFOS and PFOA in Daphnia magna.

Sci Total Environ 2019 Jun 27;667:435-443. Epub 2019 Feb 27.

Department of Environmental Science and Engineering, School of Environmental and Geographical Sciences, Shanghai Normal University, Shanghai 200234, China. Electronic address:

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are two types of perfluorinated compounds (PFCs) frequently studied in recent years due to their potential for bioaccumulation and toxicity to humans. Usually, PFCs can co-exist in various environment. Therefore, over- or under-estimated risk assessments would result if antagonism or synergism occurred in mixture toxicity. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.418DOI Listing
June 2019
3 Reads

The role of SIPK signaling pathway in antioxidant activity and programmed cell death of tobacco cells after exposure to cadmium.

Plant Sci 2019 Mar 2;280:416-423. Epub 2019 Jan 2.

Department of Plant Biology, Faculty of Biological Science, Tarbiat Modares University (TMU), Tehran, Iran.

Cadmium (Cd) toxicity induces oxidative burst and leads to programmed cell death (PCD) in plant cells. The role of salicylic acid-induced protein kinase (SIPK) signaling pathway in Cd-induced oxidative stress was investigated in suspension-cultured tobacco (Nicotiana tabacum L. cv. Read More

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http://dx.doi.org/10.1016/j.plantsci.2018.12.028DOI Listing
March 2019
1 Read
3.607 Impact Factor

Effects of perinatal exposure to BPA, BPF and BPAF on liver function in male mouse offspring involving in oxidative damage and metabolic disorder.

Environ Pollut 2019 Apr 30;247:935-943. Epub 2019 Jan 30.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Beijing, 100193, China.

Bisphenols (BPs) are common environmental pollutants that are ubiquitous in the natural environment and can affect human health. In this study, we explored the effects of perinatal exposure to BPA, BPF and BPAF on liver function involving in oxidative damage and metabolic disorders in male mouse offspring. We found that BPA exposure impairs the antioxidant defense system, increases lipid peroxidation, and causes oxidative damage in the liver. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.116DOI Listing
April 2019
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Regorafenib in patients with recurrent high-grade astrocytoma.

J Cancer Res Clin Oncol 2019 Apr 28;145(4):1037-1042. Epub 2019 Feb 28.

Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany.

Purpose: Antiangiogenic treatment approaches have failed to improve outcome in randomized trials of high-grade astrocytoma. One key mechanism of resistance to antiangiogenic treatment may concern the upregulation of alternative pro-angiogenic pathways. Regorafenib is a potent multikinase inhibitor that may alter some of those pathways. Read More

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http://dx.doi.org/10.1007/s00432-019-02868-5DOI Listing
April 2019
3 Reads