183,295 results match your criteria Toxicity Hydrocarbons


Prospecting cellulose fibre-reinforced composite membranes for sustainable remediation and mitigation of emerging contaminants.

Chemosphere 2022 Jun 24:135291. Epub 2022 Jun 24.

Tecnologico de Monterrey, School of Engineering and Science, Monterrey, 64849, Mexico. Electronic address:

Many environmental pollutants caused by uncontrolled urbanization and rapid industrial growth have provoked serious concerns worldwide. These pollutants, including toxic metals, dyes, pharmaceuticals, pesticides, volatile organic compounds, and petroleum hydrocarbons, unenviably compromise the water quality and manifest a severe menace to aquatic entities and human beings. Therefore, it is of utmost importance to acquaint bio-nanocomposites with the capability to remove and decontaminate this extensive range of emerging pollutants. Read More

View Article and Full-Text PDF

Immobilization of heavy metals by microbially induced carbonate precipitation using hydrocarbon-degrading ureolytic bacteria.

Biotechnol Rep (Amst) 2022 Sep 9;35:e00747. Epub 2022 Jun 9.

Environmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, PO. Box 2713, Doha, Qatar.

Crude oil contamination introduces multiple threats to human health and the environment, most of which are from toxic heavy metals. Heavy metals cause significant threats because of their persistence, toxicity, and bio-accumulation. Biomineralization, performed through many microbial processes, can lead to the immobilization of heavy metals in formed minerals. Read More

View Article and Full-Text PDF
September 2022

Biological toxicity risk assessment of two potential neutral carbon diesel fuel substitutes.

Environ Pollut 2022 Jun 23:119677. Epub 2022 Jun 23.

Grupo de Manejo Eficiente de la energía GIMEL, Facultad de Ingeniería Mecánica, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.

We investigated the biological response of soluble organic fraction (SOF) and water-soluble fraction (WSF) extracted from particulate matter (PM) emitted by an automotive diesel engine operating in a representative urban driving condition. The engine was fueled with ultra-low sulfur diesel (ULSD), and its binary blends by volume with 13% of butanol (Bu13), and with hydrotreated vegetable oil (HVO) at 13% (HVO13) and 20% (HVO20). Cytotoxicity, genotoxicity, oxidative DNA damage and ecotoxicity tests were carried out, and 16 polycyclic aromatic hydrocarbons (PAH) expressed as toxic benzo[a]pyrene equivalent (BaP-TEQ) were also analyzed. Read More

View Article and Full-Text PDF

Bioaccumulation, Detoxification and Biological Macromolecular Damages of Benzo[a]pyrenein Exposure in Tissues and Subcellular Fractions of Scallop Chlamys farreri.

Environ Toxicol Chem 2022 Jun 25. Epub 2022 Jun 25.

The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, 266003, PR China.

Due to the persistence and high toxicity of Benzo[a]pyrene (B[a]P), the bioaccumulation and detoxification mechanism of B[a]P have been studied extensively at the tissue level, but the data at the subcellular level in bivalves has not been reported. This study was conducted to investigate the effects of B[a]P exposure on bioaccumulation, detoxification and biomacromolecular damages in gills, digestive glands and their subcellular fractions of scallop Chlamys farreri. The subcellular fractions contains cytoplasm, mitochondria, microsome, nucleus, cell membrane and overall organelle. Read More

View Article and Full-Text PDF

Epirubicin Alters DNA Methylation Profiles Related to Cardiotoxicity.

Front Biosci (Landmark Ed) 2022 Jun;27(6):173

Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6229ER Maastricht, The Netherlands.

Background: Epirubicin (EPI) is an important anticancer drug that is well-known for its cardiotoxic side effect. Studying epigenetic modification such as DNA methylation can help to understand the EPI-related toxic mechanisms in cardiac tissue. In this study, we analyzed the DNA methylation profile in a relevant human cell model and inspected the expression of differentially methylated genes at the transcriptome level to understand how changes in DNA methylation could affect gene expression in relation to EPI-induced cardiotoxicity. Read More

View Article and Full-Text PDF

The Significance of the Ocular Adverse Effect Induced by Systemic Taxane Application.

Front Biosci (Landmark Ed) 2022 May;27(6):171

Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi, China.

In recent years, in-depth research on anti-tumor therapy has brought the emergence of new active chemotherapeutic agents and combination regimens. However, as one of them, taxane drugs are widely used in clinical practice, but it should be noted that many side reactions caused by their application bring some difficulties to routine management. Among the side reactions related to taxane anti-tumor therapy, ocular adverse reactions are occasionally reported and are not life-threatening but may seriously affect patients' life quality. Read More

View Article and Full-Text PDF

RNA-Seq and 16S rRNA Analysis Revealed the Effect of Deltamethrin on Channel Catfish in the Early Stage of Acute Exposure.

Front Immunol 2022 3;13:916100. Epub 2022 Jun 3.

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.

Deltamethrin (Del) is a widely used pyrethroid insecticide and a dangerous material that has brought serious problems to the healthy breeding of aquatic animals. However, the toxicological mechanisms of Del on channel catfish remain unclear. In the present study, we exposed channel catfish to 0, 0. Read More

View Article and Full-Text PDF

Oleanolic Acid Derivative AXX-18 Exerts Antiviral Activity by Inhibiting the Expression of HSV-1 Viral Genes UL8 and UL52.

Viruses 2022 Jun 13;14(6). Epub 2022 Jun 13.

Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Two-thirds of the world's population is infected with HSV-1, which is closely associated with many diseases, such as Gingival stomatitis and viral encephalitis. However, the drugs that are currently clinically effective in treating HSV-1 are Acyclovir (ACV), Ganciclovir, and Valacyclovir. Due to the widespread use of ACV, the number of drug-resistant strains of ACV is increasing, so searching for new anti-HSV-1 drugs is urgent. Read More

View Article and Full-Text PDF

Effect of Triclosan and Silver Nanoparticles on DNA Damage Investigated with DNA-Based Biosensor.

Sensors (Basel) 2022 Jun 8;22(12). Epub 2022 Jun 8.

Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.

Triclosan (TCS) is a broad-spectrum antimicrobial agent widely used in personal care, healthcare, and clinical practice. One of the most important aspects of toxicological profiling of compounds is their interaction with DNA. In human cells, TCS causes a significant reduction in DNA methylation. Read More

View Article and Full-Text PDF

Influence of Test Specimen Geometry and Water Soaking on the In Vitro Cytotoxicity of Orthocryl, Orthocryl LC, Loctite EA 9483 and Polypropylene.

Molecules 2022 Jun 20;27(12). Epub 2022 Jun 20.

Institute of Pharmacology and Toxicology, Rostock University Medical Center, 18057 Rostock, Germany.

Depending on their composition, plastics have a cytotoxic potential that needs to be evaluated before they are used in dentistry, e.g., as orthodontic removable appliances. Read More

View Article and Full-Text PDF

Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo.

Molecules 2022 Jun 20;27(12). Epub 2022 Jun 20.

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

To develop new compounds with high activity, broad spectrum and low-toxicity, 17 benzamides substituted with quinoline-linked 1,2,4-oxadiazole were designed using the splicing principle of active substructures and were synthesized. The biological activities were evaluated against 10 fungi, indicating that some of the synthetic compounds showed excellent fungicidal activities. For example, at 50 mg/L, the inhibitory activity of (3-Cl-4-Cl substituted, 86. Read More

View Article and Full-Text PDF

Homology Modeling and Molecular Docking Approaches for the Proposal of Novel Insecticides against the African Malaria Mosquito ().

Molecules 2022 Jun 15;27(12). Epub 2022 Jun 15.

"Coriolan Dragulescu" Institute of Chemistry, 24 M. Viteazu Ave, 300223 Timisoara, Romania.

Vector-borne infectious diseases are responsible for the deaths of over 700,000 people annually, than 400,000 of them resulting from malaria. The mosquito is one of the dominant vector species of human malaria transmission. A significant issue of the conventional insecticides which target the arthropod borne infectious diseases is their induced resistance. Read More

View Article and Full-Text PDF

Anticonvulsant Effect of Turmeric and Resveratrol in Lithium/Pilocarpine-Induced Status Epilepticus in Wistar Rats.

Molecules 2022 Jun 14;27(12). Epub 2022 Jun 14.

Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa 91000, Mexico.

Epilepsy is a chronic neurological disorder that lacks a cure. The use of plant-derived antioxidant molecules such as those contained in turmeric powder and resveratrol may produce short-term anticonvulsant effects. A total of 42 three-month-old male Wistar rats were divided into six groups ( = 7 in each group): Vehicle (purified water), turmeric (150 and 300 mg/kg, respectively), and resveratrol (30 and 60 mg/kg, respectively), administered (p. Read More

View Article and Full-Text PDF

TP-CSO: A Triptolide Prodrug for Pancreatic Cancer Treatment.

Molecules 2022 Jun 8;27(12). Epub 2022 Jun 8.

Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China.

Triptolide (TP) is a potential drug candidate for the treatment of cancer, but its use was hampered by its systemic toxicity and poor water solubility. Hence, a TP-CSO prodrug was synthesized by conjugating TP to chitosan oligosaccharide (CSO), and characterized by H NMR, FTIR, DSC and XRD analyses. The TP-CSO containing about 4 wt% of TP exhibited excellent water solubility (15 mg/mL) compared to TP (0. Read More

View Article and Full-Text PDF

The Ameliorative Effect of Empagliflozin in Vigabatrin-Induced Cerebellar/Neurobehavioral Deficits: Targeting mTOR/AMPK/SIRT-1 Signaling Pathways.

Molecules 2022 Jun 7;27(12). Epub 2022 Jun 7.

Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.

Vigabatrin (VGB) is an antiepileptic drug that acts to irreversibly inhibit the γ-aminobutyric acid (GABA) transaminase enzyme, elevating GABA levels. Broad studies have established that long-term treatment and/or high doses of VGB lead to variable visual defects. However, little attention has been paid to its other side effects, especially those demonstrating cerebellar involvement. Read More

View Article and Full-Text PDF

Nano-Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti-Tumor Effects.

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

(1) Background: Curcumin (CUR) and tetrandrine (TET) are natural compounds with various bioactivities, but have problems with low solubility, stability, and absorption rate, resulting in low bioavailability, and limited applications in food, medicine, and other fields. It is very important to improve the solubility while maintaining the high activity of drugs. Liposomes are micro-vesicles synthesized from cholesterol and lecithin. Read More

View Article and Full-Text PDF

Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in .

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

School of Pharmacy, Lanzhou University, Lanzhou 730000, China.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world. However, there is no effective drug to cure it. Caesalmin C is a cassane-type diterpenoid abundant in (Linn. Read More

View Article and Full-Text PDF

Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior.

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

Department of Pharmacology, Unit II, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland.

Clinical studies provide evidence that ketamine and psilocybin could be used as fast-acting antidepressants, though their mechanisms and toxicity are still not fully understood. To address this issue, we have examined the effect of a single administration of ketamine and psilocybin on the extracellular levels of neurotransmitters in the rat frontal cortex and reticular nucleus of the thalamus using microdialysis. The genotoxic effect and density of glutamate receptor proteins was measured with comet assay and Western blot, respectively. Read More

View Article and Full-Text PDF

Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus.

Int J Mol Sci 2022 Jun 15;23(12). Epub 2022 Jun 15.

Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

The impact of endocrine-disrupting chemicals on the development and involution of the immune system is a possible reason for the increased incidence of disorders associated with inappropriate immune function. The thymus is a lymphoid and also an endocrine organ, and, accordingly, its development and functioning may be impaired by endocrine disruptors. The aim was to evaluate age-related thymus involution in mature rats exposed to the endocrine disruptor DDT during prenatal and postnatal ontogeny. Read More

View Article and Full-Text PDF

Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries.

Int J Mol Sci 2022 Jun 7;23(12). Epub 2022 Jun 7.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The increased concern regarding the reduction in female fertility and the impressive numbers of women undergoing fertility treatment support the existence of environmental factors beyond inappropriate programming of developing ovaries. Among these factors are pyrethroids, which are currently some of the most commonly used pesticides worldwide. The present study was performed to investigate the developmental effects of the pyrethroid-based insecticide allethrin on ovarian function in rat offspring in adulthood. Read More

View Article and Full-Text PDF

The Role of Grass Compost and in Alleviating Toxic Effects of Tetracycline on the Soil Bacteria Community.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Department of Soil Science and Microbiology, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, Poland.

Given their common use for disease treatment in humans, and particularly in animals, antibiotics pose an exceptionally serious threat to the soil environment. This study aimed to determine the response of soil bacteria and oxidoreductases to a tetracycline (Tc) contamination, and to establish the usability of grass compost (G) and (Zm) in mitigating adverse Tc effects on selected microbial properties of the soil. The scope of microbiological analyses included determinations of bacteria with the conventional culture method and new-generation sequencing method (NGS). Read More

View Article and Full-Text PDF

Reduced concentrations and toxicity of sediment-associated pesticides from vegetable planting field to surrounding waterways: Impacts of chemical properties and intrinsic toxicity.

J Hazard Mater 2022 Aug 3;436:129292. Epub 2022 Jun 3.

School of Environment and Guangdong Provincial Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China.

Pesticides from agricultural activities transfer to surrounding waterways, jeopardizing aquatic ecosystem. To better characterize transfer of pesticide residues and toxicity, a batch of pesticides were analyzed in 22 sediment samples collected from the ditches (< 5 m away from field) and receiving streams nearby a vegetable planting area, South China. Sum concentrations of pesticides in ditch sediments (152 ± 121 ng/g dry wt. Read More

View Article and Full-Text PDF

Enhancing fluoroglucocorticoid defluorination using defluorinated functional strain Acinetobacter. pittii C3 via humic acid-mediated biotransformation.

J Hazard Mater 2022 Aug 6;436:129284. Epub 2022 Jun 6.

College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China. Electronic address:

Defluorination is a key factor in reducing biologically accumulated carcinogenic and teratogenic toxicity of fluoroglucocorticoids (FGCs). To enhance defluorination efficiency, a highly efficient defluorination-degrading strain Acinetobacter. pittii C3 was isolated, and the promotion mechanism through humic acid (HA)-mediated biotransformation was investigated. Read More

View Article and Full-Text PDF

Early molecular responses of mangrove oysters to nanoplastics using a microfluidic device to mimic environmental exposure.

J Hazard Mater 2022 Aug 2;436:129283. Epub 2022 Jun 2.

University of Bordeaux, CNRS, UMR EPOC 5805, équipe Ecotoxicologie Aquatique, F-33120 Arcachon, France. Electronic address:

This study assessed the effects of nanoplastics (NPs) using for the very first time microfluidic devices (chip) mimicking transition waters. Three kinds of NPs were tested: crushed NPs from polystyrene pellets (NP-PS), or from Guadeloupe beaches (NP-G); and latex PS (PSL-COOH). The eluted fractions from the microfluidic device showed a low aggregation of NPs. Read More

View Article and Full-Text PDF

Target and suspect screening of 4777 per- and polyfluoroalkyl substances (PFAS) in river water, wastewater, groundwater and biota samples in the Danube River Basin.

J Hazard Mater 2022 Aug 3;436:129276. Epub 2022 Jun 3.

Environmental Institute, Okružná 784/42, 97241 Koš, Slovak Republic.

Per- and polyfluoroalkyl substances (PFAS) are under regulatory scrutiny since some of them are persistent, bioaccumulative, and toxic. The occurrence of 4777 PFAS was investigated in the Danube River Basin (DRB; 11 countries) using target and suspect screening. Target screening involved investigation of PFAS with 56 commercially available reference standards. Read More

View Article and Full-Text PDF

New insights into humic acid-boosted conversion of bisphenol A by laccase-activated co-polyreaction: Kinetics, products, and phytotoxicity.

J Hazard Mater 2022 Aug 3;436:129269. Epub 2022 Jun 3.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China.

How humic acid (HA) modifies bisphenol A (BPA) conversion in exoenzyme-activated polyreaction is poorly understood. Herein, the influencing mechanism of HA on laccase-induced BPA self-polymerization was investigated, and the phytotoxicity of the produced BPA self/co-polymers was assessed for the first time. HA prominently boosted BPA elimination, and the rate constants of BPA conversion augmented from 0. Read More

View Article and Full-Text PDF

Effect of copper stress on Phaseolus coccineus in the presence of exogenous methyl jasmonate and/or Serratia plymuthica from the Spitsbergen soil.

J Hazard Mater 2022 Aug 26;436:129232. Epub 2022 May 26.

Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland. Electronic address:

Copper stress in the presence of exogenous methyl jasmonate and Serratia plymuthica in a complete trifactorial design with copper (0, 50 µM), methyl jasmonate (0, 1, 10 µM) and Serratia plymuthica (without and with inoculation) was studied on the physiological parameters of Phaseolus coccineus. Copper application reduced biomass and allantoin content, but increased chlorophyll and carotenoids contents as well as catalase and peroxidases activities. Jasmonate did not modify biomass and organic acids levels under copper treatment, but additional inoculation elevated biomass and content of tartrate, malate and succinate. Read More

View Article and Full-Text PDF

Transgenerational effects of polyethylene microplastic fragments containing benzophenone-3 additive in Daphnia magna.

J Hazard Mater 2022 Aug 24;436:129225. Epub 2022 May 24.

Division of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Maternal exposure to microplastics (MPs) plays an important role in the fitness of unexposed progeny. In this study, the transgenerational effects of polyethylene MP fragments (17.35 ± 5. Read More

View Article and Full-Text PDF

Succession of soil bacterial communities and network patterns in response to conventional and biodegradable microplastics: A microcosmic study in Mollisol.

J Hazard Mater 2022 Aug 24;436:129218. Epub 2022 May 24.

Key Laboratory of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin 150081, China. Electronic address:

Significant soil contamination of microplastics (MPs) by the application of agricultural mulching films has aroused global concern, however, the effects of conventional and biodegradable MPs on the dynamics of soil microbial communities and network patterns have not been sufficiently reported. In this study, we conducted a soil microcosmic experiment by adding low-density polyethylene and biodegradable MPs (PE and BD) into a black soil at the dosages of 0 % (CK), 0.1 % (low-dose, w/w), 1 % (medium-dose, w/w) and 5 % (high-dose, w/w), and soils were sampled on the 15th, 30th, 60th and 90th day of soil incubation for high-throughput sequencing. Read More

View Article and Full-Text PDF

Microplastic particles alter wheat rhizosphere soil microbial community composition and function.

J Hazard Mater 2022 Aug 18;436:129176. Epub 2022 May 18.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, Jiangsu Province 210095, People's Republic of China. Electronic address:

The wide existence of microplastics (MPs) in the terrestrial systems is proved by -many studies, and their presence could potentially change the soil chem-physical properties and processes. Various types of microplastics may have different behaviors, inducing distinct effects on the soil ecosystems. However, the knowledge of microplastic impacts on rhizosphere soil bacterial community structure is limited. Read More

View Article and Full-Text PDF