165,146 results match your criteria Toxicity Hydrocarbons


Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos.

Environ Int 2020 Jun 29;143:105913. Epub 2020 Jun 29.

Unit of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden. Electronic address:

Polycyclic aromatic compounds (PACs), including polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (oxy-PAHs), are common environmental pollutants known to cause health effects in humans and wild-life. In particular, vertebrate cardiovascular development and function are sensitive to PACs. However, the interactive effects of PAHs and oxy-PAHs on cardiovascular endpoints have not been well studied. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105913DOI Listing

Toxicity assessment of Fluoranthene, Benz(a)anthracene and its mixed pollution in soil: Studies at the molecular and animal levels.

Ecotoxicol Environ Saf 2020 Jun 27;202:110864. Epub 2020 Jun 27.

School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong, 266237, PR China. Electronic address:

An increasing amount of Fluoranthene (Fla) and Benz(a)anthracene (BaA) is being produced and used, eventually entering the soil sediments. The accumulation of Fla and BaA will cause poisoning to typical enzymes (α-Amylase) and organisms (Eisenia fetida) in soil. However, the studies about exploring and comparing the different effects of Fla, BaA and their joint effect at different levels are rarely reported. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110864DOI Listing

[Source Composition Spectrum of Volatile Organic Compounds in Typical Industries in Sichuan].

Huan Jing Ke Xue 2020 Jul;41(7):3031-3041

Sichuan Academy of Environmental Sciences, Chendu 610000, China.

In this study, typical industries that act as sources of volatile organic compound (VOCs) emission in Sichuan, including automobile manufacturing, wooden furniture, wood-based panel manufacturing, and paint production, were selected and GC-MS national standard analysis to study the organized emission VOC components of every procedure. The spectra of VOCs in the automobile industry were obtained by means of total emission normalization. The results showed that the VOC components of automobile manufacturing, wooden furniture, and oil paint manufacturing enterprises were mainly aromatic hydrocarbons and oxygen-containing compounds, accounting for more than 70% of total VOCs; the emissions from automobile part manufacturing enterprises were mainly aromatic hydrocarbons, with a ratio of over 90%. Read More

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http://dx.doi.org/10.13227/j.hjkx.201911118DOI Listing

[Contents,Sources,and Ecological Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in Surface Soils of Various Functional Zones in Yangzhou City, China].

Huan Jing Ke Xue 2020 Apr;41(4):1847-1854

School of Geographical Science, Fujian Normal University, Fuzhou 350007, China.

The contents and sources of 15 US EPA priority polycyclic aromatic hydrocarbons (PAHs) were analyzed in 59 surface soil samples (0-10 cm depth) collected from six functional zones, including cultural and educational area, park, residential area, vegetable garden, gas station, and industrial area, in Yangzhou City. The toxicity equivalent content of benzo[a]pyrene (TEQ) was adopted to assess PAH risks in soils. The results showed that the contents of Σ15PAHs in soil samples ranged from 21 to 36118 μg·kg, with a median value of 295 μg·kg. Read More

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http://dx.doi.org/10.13227/j.hjkx.201909065DOI Listing

Toxicity assessment of electrochemical advanced oxidation process-treated groundwater from a gas station with petrochemical contamination.

Environ Monit Assess 2020 Jun 30;192(7):473. Epub 2020 Jun 30.

Emerging Compounds Research Center, Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, Neipu, Pingtung County, 912, Taiwan.

Electrochemical advanced oxidation process (EAOP) is known for its efficient and fast degradation of organic pollutants in polluted water treatment. In this study, the EAOP using a boron-doped diamond (BDD) anode was applied to treat two-season groundwater samples collected from four sampling wells (GS1 to GS4) with petrochemical contaminants including methyl tert-butyl ether (MTBE), benzene, toluene, chlorobenzene, total organic compounds (TOC), and total petroleum hydrocarbons (TPH) at a gas station in southern Taiwan. Moreover, toxicity tests (ATP, p53, and NF-κB bioassays) were performed to evaluate the biological responses of raw and EAOP-treated groundwater. Read More

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http://dx.doi.org/10.1007/s10661-020-08393-0DOI Listing

Polycyclic aromatic compounds (PACs) in the Canadian environment: Exposure and effects on wildlife.

Environ Pollut 2020 Jun 13;265(Pt B):114863. Epub 2020 Jun 13.

Institut National de la Recherche Scientifique (INRS), Centre Eau Terre Environnement, Quebec, QC, Canada. Electronic address:

Polycyclic aromatic compounds (PACs) are ubiquitous in the environment. Wildlife (including fish) are chronically exposed to PACs through air, water, sediment, soil, and/or dietary routes. Exposures are highest near industrial or urban sites, such as aluminum smelters and oil sands mines, or near natural sources such as forest fires. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114863DOI Listing

Effects of benzo[a]pyrene toxicity on morphology and ultrastructure of Hordeum sativum.

Environ Geochem Health 2020 Jun 28. Epub 2020 Jun 28.

Southern Federal University, Rostov-on-Don, Russian Federation.

Many studies have been devoted to investigation of toxic benzo(a)pyrene (BaP) compound, but studies involving changes at the cellular level are insufficient to understand the mechanisms of polycyclic aromatic hydrocarbons (PAHs) effect on plants. To study the toxicity of BaP, a model vegetation experiment was conducted on cultivation of spring barley (Hordeum sativum distichum) on artificially polluted BaP soil at different concentrations. The article discusses the intake of BaP from the soil into the plant and its effect on the organismic and cellular levels of plant organization. Read More

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http://dx.doi.org/10.1007/s10653-020-00647-7DOI Listing

Semi-volatile components of PM in an urban environment: volatility profiles and associated oxidative potential.

Atmos Environ (1994) 2020 Feb 2;223. Epub 2019 Dec 2.

University of Southern California, Department of Civil and Environmental Engineering, Los Angeles, CA, USA.

The volatility profiles of PM semi-volatile compounds and relationships to the oxidative potential of urban airborne particles were investigated in central Los Angeles, CA. Ambient and thermodenuded fine (PM) particles were collected during both warm and cold seasons by employing the Versatile Aerosol Concentration Enrichment System (VACES) combined with a thermodenuder. When operated at 50 °C and 100 °C, the VACES/thermodenuder system removed about 50% and 75% of the PM volume concentration, respectively. Read More

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http://dx.doi.org/10.1016/j.atmosenv.2019.117197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311065PMC
February 2020

Treatment of coking wastewater in biofilm-based bioaugmentation process: Biofilm formation and microbial community analysis.

J Hazard Mater 2020 Jun 13;400:123117. Epub 2020 Jun 13.

School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Coking wastewater (CWW) containing complicated organic compositions and strong toxicity cause potential hazards to natural water bodies as well as human health. The aim of this study was integrating newly isolated Comamonas sp. ZF-3, biofilm-based bioaugmentation and fluidized bed reactor into an anoxic filter-fluidized bed reactor (AF-FBR) system to treat actual CWW. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123117DOI Listing

Toxicity of exhaust particulates and gaseous emissions from gasohol (ethanol blended gasoline)-fuelled spark ignition engines.

Environ Sci Process Impacts 2020 Jun 23. Epub 2020 Jun 23.

Department of Biological Sciences & Bioengineering, Indian Institute of Technology Kanpur, Kanpur-208016, India.

In the last couple of decades, blending of oxygenated additives with gasoline has been advocated to reduce dependence on fossil fuels and to reduce hazardous health effects of gaseous emissions and particulate matter (PM) emitted by internal combustion (IC) engines in the transport sector worldwide. The primary objective of this research was to carry out a comparative analysis of exhaust PM emitted by gasohol (gasoline blended with 10% ethanol, v/v)-fulled spark ignition (SI) engine with that of baseline gasoline-fuelled SI engine. To assess the PM toxicity, physical, chemical and biological characterizations of PM were carried out using the state-of-the-art instruments and techniques. Read More

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http://dx.doi.org/10.1039/d0em00082eDOI Listing

Use of biomass ash to reduce toxicity affecting soil bacterial community growth due to tetracycline antibiotics.

J Environ Manage 2020 Sep 30;269:110838. Epub 2020 May 30.

Área de Edafoloxía e Química Agrícola, Facultade de Ciencias, Universidade de Vigo, As Lagoas 1, 32004, Ourense, Spain.

Tetracycline antibiotics (TA) used in veterinary medicine reach terrestrial ecosystems mostly via the repeated applications of animal manures and slurries on agricultural soils, where they may cause toxic effects on bacterial communities. In the current work, we studied the efficacy of adding doses of 0, 6, 24 and 48 g kg of biomass ash (BA) to four different soils to reduce potential negative effects of tetracycline antibiotics. Specifically, soil samples were polluted with different concentrations of tetracycline, oxytetracycline or chlortetracycline, and the bacterial community growth was estimated using the H leucine incorporation technique. Read More

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http://dx.doi.org/10.1016/j.jenvman.2020.110838DOI Listing
September 2020

Biological effects of chronic and acute exposure of human endothelial cell line EA.hy926 to bisphenol A: New tricks from an old dog.

Chemosphere 2020 Oct 21;256:127159. Epub 2020 May 21.

University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Serbia.

Although epidemiological and animal studies suggest a possible correlation between bisphenol A (BPA) exposure and atherosclerosis, very few in vitro mechanistic and functional studies regarding the effect of BPA on vascular cells have been conducted. Here, we applied a "real-life" exposure scenario by continuously exposing human endothelial cell (EC) line EA.hy926 to environmentally relevant concentrations of BPA (10, 10, and 10 M) during 14 weeks. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127159DOI Listing
October 2020
3.340 Impact Factor

Diphenamid photodegradation using Fe(III) impregnated N-doped TiO/sulfite/visible LED process: Influence of wastewater matrix, kinetic modeling, and toxicity evaluation.

Chemosphere 2020 Oct 17;256:127094. Epub 2020 May 17.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Sulfite-based photocatalysis has been recently employed as a promising technology for the treatment of organic pollutants via the generation of reactive radicals. In this contribution, the effect of wastewater matrix constituents and toxicity evaluation were systematically investigated in the Fe impregnated N-doped TiO (FeN-TiO)/sulfite/visible LED (Vis LED) process in the presence of diphenamid (DPA) as a model organic pollutant. The results showed that the presence of HCO, SO, NO, and F had no detrimental effect on DPA degradation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127094DOI Listing
October 2020

The efficacy and safety of daunorubicin versus idarubicin combined with cytarabine for induction therapy in acute myeloid leukemia: A meta-analysis of randomized clinical trials.

Medicine (Baltimore) 2020 Jun;99(24):e20094

Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Objective: To ascertain the efficacy and safety of daunorubicin combined with cytarabine comparing with idarubicin combined with cytarabine as a standard induction therapy for acute Myeloid leukemia by a meta-analysis.

Methods: The randomized controlled trials included were retrieved from PubMed, Embase, and Cochrane library. We evaluated and cross-checked the randomized clinical trials (RCTs) comparing daunorubicin combined with cytarabine (DA) and idarubicin combined with cytarabine (IA) by two reviewers independently according to Cochrane Handbook for Systematic Reviewers of Interventions. Read More

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http://dx.doi.org/10.1097/MD.0000000000020094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302600PMC

Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.

Part Fibre Toxicol 2020 06 15;17(1):27. Epub 2020 Jun 15.

Department of Environmental and Biological Sciences, University of Eastern Finland, Yliopistonranta 1, P.O.Box 1627, FI-70210, Kuopio, Finland.

Background: Wood combustion emissions have been studied previously either by in vitro or in vivo models using collected particles, yet most studies have neglected gaseous compounds. Furthermore, a more accurate and holistic view of the toxicity of aerosols can be gained with parallel in vitro and in vivo studies using direct exposure methods. Moreover, modern exposure techniques such as air-liquid interface (ALI) exposures enable better assessment of the toxicity of the applied aerosols than, for example, the previous state-of-the-art submerged cell exposure techniques. Read More

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http://dx.doi.org/10.1186/s12989-020-00355-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296712PMC

Transcriptome changes of Takifugu obscurus liver after acute exposure to the oxygenated-PAH 9,10-phenanthrenequione.

Physiol Genomics 2020 Jun 15. Epub 2020 Jun 15.

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, China.

Contamination with polycyclic aromatic hydrocarbons (PAHs) causes noticeable ecological problems in aquatic ecosystems. 9,10-phenanthrenequione (9,10-PQ) is an oxidized PAH and is highly toxic to aquatic animals. However, the effects of 9,10-PQ on the molecular metabolism of fish remain largely unknown. Read More

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http://dx.doi.org/10.1152/physiolgenomics.00022.2020DOI Listing

Role of photo- and biodegradation of two PAHs on leaves: Modelling the impact on air quality ecosystem services provided by urban trees.

Sci Total Environ 2020 Jun 6;739:139893. Epub 2020 Jun 6.

Department of Science and High Technology, University of Insubria, Via Valleggio 11, 22100 Como, Italy.

Urban trees provide important ecosystem services, including air quality improvement. Polycyclic aromatic hydrocarbons (PAHs) are among the most important pollutants in air, due to their elevated concentrations and toxicity. Plants can act as filters of PAHs and as "chemical reactors" for pollutant removal, therefore reducing air concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139893DOI Listing

Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon.

J Trace Elem Med Biol 2020 May 24;61:126563. Epub 2020 May 24.

University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany. Electronic address:

Arsenolipids, especially arsenic-containing hydrocarbons (AsHC), are an emerging class of seafood originating contaminants. Here we toxicologically characterize a recently identified oxo-AsHC 332 metabolite, thioxo-AsHC 348 in cultured human liver (HepG2) cells. Compared to results of previous studies of the parent compound oxo-AsHC 332, thioxo-AsHC 348 substantially affected cell viability in the same concentration range but exerted about 10-fold lower cellular bioavailability. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126563DOI Listing

Primary Sources of Polycyclic Aromatic Hydrocarbons to Streambed Sediment in Great Lakes Tributaries Using Multiple Lines of Evidence.

Environ Toxicol Chem 2020 Jul 11;39(7):1392-1408. Epub 2020 Jun 11.

Institute for Atmospheric and Earth System Research, University of Helsinki, Helsinki, Finland.

Polycyclic aromatic hydrocarbons (PAHs) are among the most widespread and potentially toxic contaminants in Great Lakes (USA/Canada) tributaries. The sources of PAHs are numerous and diverse, and identifying the primary source(s) can be difficult. The present study used multiple lines of evidence to determine the likely sources of PAHs to surficial streambed sediments at 71 locations across 26 Great Lakes Basin watersheds. Read More

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http://dx.doi.org/10.1002/etc.4727DOI Listing

Simultaneous determination of carcinogenic PAHs and levoglucosan bound to PM for assessment of health risk and pollution sources during a smoke haze period.

Chemosphere 2020 May 22;257:127154. Epub 2020 May 22.

Department of Environmental Engineering and Science, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan. Electronic address:

Carcinogenic polycyclic aromatic hydrocarbons (cPAHs) in ambient PM and a specific molecular marker of biomass burning, levoglucosan, are used to investigate the influence on public health of biomass burning. In this work, we present an effective method for one-time analysis of cPAHs and levoglucosan by GC-MS without derivatization. The method was applied for the analysis of PM samples (64. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127154DOI Listing

The sensitivity of the deepsea species northern shrimp (Pandalus borealis) and the cold-water coral (Lophelia pertusa) to oil-associated aromatic compounds, dispersant, and Alaskan North Slope crude oil.

Mar Pollut Bull 2020 Jul 17;156:111202. Epub 2020 May 17.

Akvaplan-niva, Fram Centre, Tromsø, Troms, Norway.

This study investigated the sensitivity of two deepsea species using mortality of northern shrimp (Pandalus borealis) and polyp activity of stony coral (Lophelia pertusa) to dispersant, Corexit 9500 and aromatic hydrocarbons (toluene, 2-methylnaphthalene, phenanthrene) in 96-h tests. Resulting hydrocarbon toxicity data were fit to the Target Lipid Model to generate predictive models and determine species sensitivity. Toxicity of chemically enhanced water accommodated fractions of Alaskan North Slope crude oil (ANS-oil) was also investigated with shrimp using nominal loading, total petroleum hydrocarbons and biomimetic extraction (BE) as oil exposure metrics. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.111202DOI Listing

Toxicity of a mixture of monoaromatic hydrocarbons (BTX) to a tropical marine microcrustacean.

Mar Pollut Bull 2020 Jul 23;156:111272. Epub 2020 May 23.

Graduate Program in Ecology and Conservation, Federal University of Sergipe, Av. Marechal Rondon s/n, CEP 49100-000 São Cristóvão, Sergipe, Brazil; Biology Institute, Federal University of Uberlândia, Av. Ceará, s/n Bloco D sala 28, 38405-302 Uberlândia, Minas Gerais, Brazil. Electronic address:

This study evaluated the toxicity of benzene, toluene, and xylenes (BTX), isolated and in binary mixtures to Mysidopsis juniae. The organisms were exposed to BTX, and combined effect patterns were predicted by applying the theoretical models of Concentration Addition and Independent Action. According to the LC50 of the isolated compounds, xylene (16. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.111272DOI Listing

Risk assessment of Arctic aquatic species using ecotoxicological biomarkers and Bayesian network.

Mar Pollut Bull 2020 Jul 12;156:111212. Epub 2020 May 12.

Centre for Risk, Integrity and Safety Engineering (C-RISE), Faculty of Engineering and Applied Science, Memorial University of Newfoundland, St. John's, NL A1B 3X5, Canada. Electronic address:

The risk to Arctic aquatic species due to accidental oil spills is not well studied. One of the key reasons for this limitation is the lack of understanding of the dose-response relations for the species in the Arctic region. The present study addresses this knowledge gap. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.111212DOI Listing

Carbon-fluorine bond cleavage mediated by metalloenzymes.

Chem Soc Rev 2020 Jun 8. Epub 2020 Jun 8.

Department of Chemistry, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.

Fluorochemicals are a widely distributed class of compounds and have been utilized across a wide range of industries for decades. Given the environmental toxicity and adverse health threats of some fluorochemicals, the development of new methods for their decomposition is significant to public health. However, the carbon-fluorine (C-F) bond is among the most chemically robust bonds; consequently, the degradation of fluorinated hydrocarbons is exceptionally difficult. Read More

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http://dx.doi.org/10.1039/c9cs00740gDOI Listing

Biomarkers responses of the clam in sediment toxicity bioassays using dredged materials from a semi-arid coastal system.

Heliyon 2020 May 29;6(5):e04030. Epub 2020 May 29.

Núcleo de Estudos em Poluição e Ecotoxicologia Aquática, UNESP São Vicente, Brazil.

Few test organisms are employed for sediment toxicity assessments in Tropical regions, including Brazil. We assessed the ability of the clam to respond to contamination in sediment bioassays using dredging materials of a semi-arid region (Ceará State, NE Brazil), with attention to sublethal responses. Sediments were collected during and after dredging (survey 1 and 2, respectively) and animals exposed in laboratory over 28 days, with responses measured at 7 days. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264064PMC

Defensive responses of microalgal-bacterial granules to tetracycline in municipal wastewater treatment.

Bioresour Technol 2020 Sep 30;312:123605. Epub 2020 May 30.

Advanced Environmental Biotechnology Centre, Nanyang Environment & Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, Singapore 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. Electronic address:

Nowadays, tetracycline has been frequently detected in municipal wastewater, posing a pressing threat for wastewater treatment. This study investigated the defensive responses of microalgal-bacterial granules to tetracycline. It was found that the physical structure of microalgal-bacterial granules tended to shift from individual granules to loosely inter-connected agglomerates. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123605DOI Listing
September 2020

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19.

Sci Immunol 2020 06 5;5(48). Epub 2020 Jun 5.

Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, MD; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD; Willamette Valley Cancer Institute and Research Center, US Oncology, Eugene, OR; Hematology-Oncology Department, Walter Reed National Military Medical Center, Bethesda, MD; John Theurer Cancer Center, Hackensack Meridian and School of Medicine at Seton Hall, NJ; Rocky Mountain Cancer Center, US Oncology, Colorado Springs, CO; Department of Emergency Medicine, Penrose-St. Francis Health Services, Colorado Springs, CO; US Acute Care Solutions, Canton, OH; Department of Medicine, St. Peter's Hospital and US Oncology, Albany, NY; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD; Acerta Pharma, South San Francisco, CA; Biometric Research Branch, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Bethesda, MD, USA AstraZeneca, One MedImmune Way, Gaithersburg, MD

Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-19 (11 on supplemental oxygen; 8 on mechanical ventilation), 18 of whom had increasing oxygen requirements at baseline. Read More

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http://dx.doi.org/10.1126/sciimmunol.abd0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274761PMC

Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure.

Part Fibre Toxicol 2020 06 5;17(1):22. Epub 2020 Jun 5.

Department of Toxicology, School of Public Health, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, 510080, China.

Background: Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanisms have yet to be defined.

Results: Male C57BL/6 J mice were fed with a CR diet or ad libitum (AL) and exposed to PM for 4 weeks in a real-ambient PM exposure system located at Shijiazhuang, China, with a daily mean concentration (95. Read More

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http://dx.doi.org/10.1186/s12989-020-00354-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275546PMC

Nontargeted mass-spectral detection of chloroperfluoropolyether carboxylates in New Jersey soils.

Science 2020 06;368(6495):1103-1107

Senior Environmental Employment Program, Office of Research and Development, USEPA, Athens, GA, USA.

The toxicity and environmental persistence of anthropogenic per- and poly-fluoroalkyl substances (PFAS) are of global concern. To address legacy PFAS concerns in the United States, industry developed numerous replacement PFAS that commonly are treated as confidential information. To investigate the distribution of PFAS in New Jersey, soils collected from across the state were subjected to nontargeted mass-spectral analyses. Read More

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http://dx.doi.org/10.1126/science.aba7127DOI Listing

Spatiotemporal toxicity assessment of suspended particulate matter (SPM)-bound polycyclic aromatic hydrocarbons (PAHs) in Lake Chaohu, China: Application of a source-based quantitative method.

Sci Total Environ 2020 Jul 18;727:138690. Epub 2020 Apr 18.

MOE Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

The spatiotemporal associations between the emissions and environmental toxicities of polycyclic aromatic hydrocarbons (PAHs) in lake still remain an issue. Here, we focused on the suspended particulate matter (SPM)-bound PAHs in Lake Chaohu, China to quantitatively estimate their spatiotemporal toxicities from different sources. A source-based quantitative method, positive matrix factorization (PMF)-benzo[a]pyrene-based toxic equivalency (TEQ) model, was applied. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138690DOI Listing
July 2020
4.099 Impact Factor

Photochemical transformation of perfluoroalkyl acid precursors in water using engineered nanomaterials.

Water Res 2020 Aug 20;181:115964. Epub 2020 May 20.

Department of Environmental Science & Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address:

The production of perfluoroalkyl acids (PFAAs) has been phased out over recent decades; however, no significant decline in their environmental concentrations has been observed. This is partly due to the photochemical decomposition of PFAAs precursors (PrePFAAs) which remain in extensive use. The decomposition of PrePFAAs may be accelerated by the light-activated engineered nanomaterials (ENMs) in water. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115964DOI Listing

Distributions, compositions, and ecological risk assessment of polycyclic aromatic hydrocarbons and phthalic acid esters in surface sediment of Songhua river, China.

Mar Pollut Bull 2020 Mar 17;152:110923. Epub 2020 Feb 17.

State Key Laboratory of Environmental Criteria And Risk Assessment, Chinese Research Academy of Environmental Sciences, No. 8 Da Yang Fang, Anwai, Chaoyang District, Beijing 100012, PR China; Research Center for Environmental Pollution Control Engineering, Chinese Research Academy of Environmental Sciences, Beijing 100012, PR China.

The distribution, composition, and ecological risk of 16 types of polycyclic aromatic hydrocarbons (PAHs) and 6 types of phthalic acid esters (PAEs) in the surface sediment of Songhua river, northeast China, were investigated. The total weight of the PAHs (∑PAHs) varied from 226.70 to 7086. Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.110923DOI Listing
March 2020
2.991 Impact Factor

Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis.

J Environ Pathol Toxicol Oncol 2020 ;39(1):13-21

Department of Medical Imaging, Shandong Provincial Hospital Affiliated with Shandong University, Huaiyin District, Jinan, Shandong 250021, People's Republic of China.

Breast cancer is a widespread disease that affects women globally. Diagnostic processes and remedial approaches to breast carcinogenesis have improved in recent decades, but continuous survival of patients with breast carcinogenesis is still lacking due to increased cell proliferation. The aim of the present work is to explore the anticell proliferative effects of nobiletin (NOB) against 7,12-dimethylbenz[a]anthracene (DMBA)-treated mammary tumorigenesis in rats. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2019031445DOI Listing

Clozapine Improves Behavioral and Biochemical Outcomes in a MK-801-Induced Mouse Model of Schizophrenia.

J Environ Pathol Toxicol Oncol 2020 ;39(1):1-12

Department of Medical Elementology and Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.

Glutamatergic N-methyl-D-aspartate (NMDA) receptors have critical roles in several neurological and psychiatric diseases. Dizocilpine (MK-801) is a ligand at phencyclidine recognition sites that is associated with NMDA receptor-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate receptors. In this study, we investigate the effect of clozapine on MK-801-induced neurochemical and neurobehavioral alterations in the prefrontal cortex of mice. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2019030362DOI Listing

[Effects of ginsenoside Rg5 on cell cycle and invasion of gastric cancer].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Jan;36(1):51-54

Department of General Tumor Surgery, Xinxiang Central Hospital, Xinxiang 453000.

Objective: To investigate the effects of ginsenoside Rg5 on the proliferation, cycle and invasion of gastric carcinoma cell lines, providing experimental evidence for the anti-tumor mechanism of ginsenoside Rg5.

Methods: In this experimental study, the human immortalized normal gastric mucosa cell GES-1 and gastric adenocarcinoma cell lines AGS and MKN-45 were treated with Rg3 and Rg5 at the concentrations of 10, 20, 30, 40 and 50 μmol/L for 24 h, 3 parallel holes were set for each group. A cell viability test, cell cycle analysis, transwell assay, ELISA and immunoblotting were performed. Read More

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http://dx.doi.org/10.12047/j.cjap.5891.2020.011DOI Listing
January 2020

Impact of necrophytoremediation on petroleum hydrocarbon degradation, ecotoxicity and soil bacterial community composition in diesel-contaminated soil.

Environ Sci Pollut Res Int 2020 May 31. Epub 2020 May 31.

Centre for Environmental Sustainability and Remediation, School of Science, RMIT University, Bundoora, Victoria, 3083, Australia.

Hydrocarbon degradation is usually measured in laboratories under controlled conditions to establish the likely efficacy of a bioremediation process in the field. The present study used greenhouse-based bioremediation to investigate the effects of natural attenuation (NA) and necrophytoremediation (addition of pea straw (PS)) on hydrocarbon degradation, toxicity and the associated bacterial community structure and composition in diesel-contaminated soil. A significant reduction in total petroleum hydrocarbon (TPH) concentration was detected in both treatments; however, PS-treated soil showed more rapid degradation (87%) after 5 months together with a significant reduction in soil toxicity (EC = 91 mg diesel/kg). Read More

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http://dx.doi.org/10.1007/s11356-020-09339-2DOI Listing

Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19.

Int J Mol Sci 2020 May 27;21(11). Epub 2020 May 27.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.

At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus disease-19 (COVID-19)), which frequently leads to lethal pulmonary inflammatory responses. COVID-19 pathology is characterized by extreme inflammation and amplified immune response with activation of a cytokine storm. A subsequent progression to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can take place, which is often followed by death. Read More

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http://dx.doi.org/10.3390/ijms21113812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312074PMC

Does salinity variation increase synergistic effects of triclosan and carbon nanotubes on Mytilus galloprovincialis? Responses on adult tissues and sperms.

Sci Total Environ 2020 Sep 5;734:138837. Epub 2020 May 5.

Interuniversity Consortium of Marine Biology of Leghorn "G. Bacci", 57128 Livorno, Italy; Department of Veterinary Sciences, University of Pisa, San Piero a Grado, 56122 Pisa, Italy.

The use of carbon nanotubes (CNTs) is rapidly increasing and several scientific studies have addressed their toxicological properties. However, only a very small number of publications have deal with the interaction between CNTs and other molecules. Triclosan (TCS) is an antibacterial agent used in personal care and household products. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138837DOI Listing
September 2020

Adverse effects of levofloxacin and oxytetracycline on aquatic microbial communities.

Sci Total Environ 2020 Sep 16;734:139499. Epub 2020 May 16.

College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

The widespread use of levofloxacin (LEV) and oxytetracycline (OTC) in hospitals and farms inevitably contributes to water pollution through waste disposal processes, municipal wastewater treatment, and manure application to farmlands, which adversely affects aquatic microorganisms. Here, we evaluated the toxicity of LEV and OTC to cyanobacteria and eukaryotic algae monocultures and freshwater microcosms. Three test cyanobacteria were inhibited by both LEV and OTC at all examined concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139499DOI Listing
September 2020

Interleukin-9 aggravates doxorubicin-induced cardiotoxicity by promoting inflammation and apoptosis in mice.

Life Sci 2020 Aug 25;255:117844. Epub 2020 May 25.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Cardiology, Wuhan, China. Electronic address:

Aims: Interleukin (IL) 9 is a pleiotropic cytokine, and recent studies have demonstrated that IL-9 is associated with several cardiovascular diseases, via regulation of the inflammatory response. Doxorubicin (DOX) is known to induce severe cardiac injury and dysfunction by enhancing inflammation. This study aimed to investigate the role of IL-9 in DOX-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117844DOI Listing
August 2020
2.702 Impact Factor

Dysbiosis in the Gut Microbiota of Soil Fauna Explains the Toxicity of Tire Tread Particles.

Environ Sci Technol 2020 Jun 4;54(12):7450-7460. Epub 2020 Jun 4.

State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing 100085, P. R. China.

Tread particles (TPs) from vehicle tires are widely distributed in soil ecosystems; therefore, there is an urgent need to evaluate their effects on soil biota. In the present study, the soil worm was incubated for 21 days in soil microcosms containing increasing concentrations of TPs (0, 0.0048%, 0. Read More

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http://dx.doi.org/10.1021/acs.est.0c00917DOI Listing

Developmental toxicity and transcriptome analysis of 4-epianhydrotetracycline to zebrafish (Danio rerio) embryos.

Sci Total Environ 2020 Sep 7;734:139227. Epub 2020 May 7.

Key Laboratory of Yangtze River Water Environment of the Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, PR China. Electronic address:

As a primary degradation by-product of tetracycline (TC), 4-Epianhydrotetracycline (4-EATC) has been detected frequently in the aquatic environment, which may pose a potential environmental risk to aquatic organisms. Up to now, however, the toxicology study on 4-EATC to aquatic organisms is limited. In the present study, in order to better understand the toxic mechanism of 4-EATC, developmental toxicity including lethal and sublethal effects of 4-EATC and TC were investigated. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139227DOI Listing
September 2020

Probing the toxic interactions between polyvinyl chloride microplastics and Human Serum Albumin by multispectroscopic techniques.

Sci Total Environ 2020 Sep 8;734:139219. Epub 2020 May 8.

Key Laboratory of Marine Eco-Environmental Science and Technology, Marine Bioresource and Environment Research Center, First Institute of Oceanography, Ministry of Natural Resources (MNR), 6 Xianxialing Road, Qingdao 266061, PR China; Laboratory of Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Qingdao 266237, PR China. Electronic address:

In this study, the interaction of emerging pollutant polyvinyl chloride microplastics (PVC MPs) and human serum albumin (HSA) was investigated by fluorescence spectroscopy, UV-visible (UV-vis) absorption spectroscopy, circular dichroism (CD), and Fourier transform infrared (FT-IR) spectroscopy under simulated physiological conditions. Fluorescence results showed that PVC MPs (about 5000 nm in size) can effectively quench the intrinsic fluorescence of HSA through static quenching owing to the formation of HSA-PVC complex. The binding constants (K) between PVC and HSA at different temperatures were calculated as 4. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139219DOI Listing
September 2020

Effect of lignin and plant growth-promoting bacteria (Staphylococcus pasteuri) on microbe-plant Co-remediation: A PAHs-DDTs Co-contaminated agricultural greenhouse study.

Chemosphere 2020 Oct 18;256:127079. Epub 2020 May 18.

Key Laboratory of Regional Environment and Eco-remediation, Shenyang University, Shenyang, 110044, China. Electronic address:

Due to the ecological toxicity and environmental residues, how to remove the persistent organic pollutants (POPs), especially of polycyclic-aromatic-hydrocarbons (PAHs) and dichloro-diphenyl-trichloroethanes (DDTs), from agricultural soil has captured the attention of scholars for a long time. To develop an effective and low-cost in situ co-remediation technique, five independent but complementary treatments were used on an over-standard PAHs-DDTs co-contaminated soil in an agricultural greenhouse. Experimental results identified that the combination of microbe (Bacillus methylotrophicus) - plant (Brassica rapa) could remove rhamnolipid activated PAHs and DDTs effectively after enhanced by Staphylococcus pasteuri. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127079DOI Listing
October 2020

UDP-glycosyltransferases contribute to spirotetramat resistance in Aphis gossypii Glover.

Pestic Biochem Physiol 2020 Jun 23;166:104565. Epub 2020 Mar 23.

College of Plant Science, Jilin University, Changchun 130062, PR China; School of Agricultural Science, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze the conjugation of small lipophilic endogenous and exogenous compounds with sugars to produce water-soluble glycosides, playing an important role in insect endobiotic regulation and xenobiotic detoxification. In this study, two UGT-inhibitors, sulfinpyrazone and 5-nitrouracil, significantly increased spirotetramat toxicity against third instar nymphs of resistant Aphis gossypii, whereas there were no synergistic effects in apterous adult aphids, suggesting UGT involvement in spirotetramat resistance in cotton aphids. Furthermore, the UHPLC-MS/MS was employed to determine the content of spirotetramat and its four metabolites (S-enol, S-glu, S-mono, S-keto) in the honeydew of resistant cotton aphids under spirotetramat treatment. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104565DOI Listing

Assessing the acute toxicity of insecticides to the buff-tailed bumblebee (Bombus terrestris audax).

Pestic Biochem Physiol 2020 Jun 6;166:104562. Epub 2020 Mar 6.

Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK. Electronic address:

The buff-tailed bumblebee, Bombus terrestris audax is an important pollinator within both landscape ecosystems and agricultural crops. During their lifetime bumblebees are regularly challenged by various environmental stressors including insecticides. Historically the honey bee (Apis mellifera spp. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294345PMC

Actions on mammalian and insect nicotinic acetylcholine receptors of harmonine-containing alkaloid extracts from the harlequin ladybird Harmonia axyridis.

Pestic Biochem Physiol 2020 Jun 6;166:104561. Epub 2020 Mar 6.

School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Electronic address:

The harlequin ladybird, Harmonia axyridis (H. axyridis), possesses a strong chemical defence that has contributed to its invasive success. Ladybird beetle defensive chemicals, secreted in response to stress and also found on the coating of laid eggs, are rich in alkaloids that are thought to be responsible for this beetle's toxicity to other species. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104561DOI Listing

Concentrations, distributions, sources, and risk assessment of polycyclic aromatic hydrocarbons in topsoils around a petrochemical industrial area in Algiers (Algeria).

Environ Sci Pollut Res Int 2020 May 22. Epub 2020 May 22.

Laboratoire d'Hydrométallurgie et Chimie Inorganique Moléculaire, USTHB, BP 32 El Alia, 16111, Bab Ezzouar, Algeria.

Fifty-five samples were collected from topsoils around a petrochemical industrial area at the east of Algiers (Algeria) and analyzed for 16EPA priority PAHs in the aim to determine the concentrations, the distributions, and the possible sources of polycyclic aromatic hydrocarbons (PAHs). The results of the quantification are then devoted to the assessment of the potential risks as the toxicity, the risk for the ecosystem, and the risk for the human health. The sampling sites were classified into four categories: rural, suburban, urban, and industrial-urban. Read More

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http://dx.doi.org/10.1007/s11356-020-09241-xDOI Listing

Enhancement of auxiliary agent for washing efficiency of diesel contaminated soil with surfactants.

Chemosphere 2020 Aug 18;252:126494. Epub 2020 Mar 18.

Department of Environmental Science and Engineering College, Donghua University, Shanghai, 201620, China; Shanghai Institution of Pollution Control and Ecological Security, Shanghai, 200092, PR China. Electronic address:

We used five types of surfactants assisted with sodium salts, including sodium tartrate (ST), sodium chloride (SC), and humic acid sodium (HAS) as auxiliary agents for soil washing to remove diesel from contaminated soil. Decontamination enhancement of diesel polluted soil washing with biosurfactant and HO was examined, which showed higher effectiveness for newly contaminated soil. An increase in temperature and sodium salt addition exhibited a profound enhancement in diesel removal from aged contaminated soils. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126494DOI Listing
August 2020
3.340 Impact Factor