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Life Sci 2019 Mar 26;220:76-83. Epub 2019 Jan 26.

Department of Toxicology, MOE Key Laboratory of Environmental and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

Aims: Deltamethrin (DM), a type II synthetic pyrethroid insecticide, is widely used in agriculture and home pest control. The evaluation of their toxic effects is of major concern to public health. However, the molecular mechanism of DM-induced neurodegenerative disease is still far from clear. Read More

Ecotoxicol Environ Saf 2019 Mar 30;169:928-936. Epub 2018 Nov 30.

Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou 510642, PR China. Electronic address:

In this work, we firstly tested five spatial repellent pyrethroids, meperfluthrin, dimefluthrin, heptafluthrin, metofluthrin and transfluthrin, to determine the susceptibility of pyrethroids to field strains of Culex quinquefasciatus using adult topical bioassay. The results showed that though field strains exhibited the highest resistance to dimefluthrin among the selected five pyrethroids, it still can be considered low resistance in the scale of Cui et al. (2006; 2007). Read More

Ecotoxicol Environ Saf 2019 Mar 29;169:829-836. Epub 2018 Nov 29.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Pentachlorophenol (PCP) is often used as chlorinated hydrocarbon herbicides and insecticides, which has been suggested that toxicity of carcinogenic effect, teratogenic effect and reproductive system. However, there was still precious known about the underlying molecular mechanism of PCP on mammalian early development. To explore the developmental toxicity of PCP and its potential mechanism, pregnancy ICR mice except controls were exposed to PCP (0. Read More

Ecotoxicol Environ Saf 2019 Mar 29;169:807-813. Epub 2018 Nov 29.

Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, NO.19 Xinjiekouwai Street, Beijing 100875, China. Electronic address:

In this work, the essential oils (EO) were extracted from seven typical Chinese herbs, and their repellent and contact toxicities against Tribolium castaneum adults (red flour beetles) were evaluated. The experimental results showed that the above EOs presented the various levels of repellent and contact toxicities. The EOs extracted from A. Read More

Aquat Toxicol 2019 Feb 14;207:187-196. Epub 2018 Dec 14.

Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg, Denmark. Electronic address:

The ability of azole fungicides to inhibit cytochrome P450 dependent metabolism is proposed to be the main mechanism for their synergizing effect on pyrethroid insecticide toxicity in aquatic invertebrates. This study investigates the correlation between inhibition strength and synergistic potential of azole fungicides in the crustacean Daphnia magna and the insect larvae Chironomus riparius. Inhibition strength was measured in vivo toward the cytochrome P450 catalysed conversion of 7-ethoxycoumarin to 7-hydroxycoumarin (ECOD). Read More

Environ Toxicol Pharmacol 2019 Jan 23;65:40-45. Epub 2018 Nov 23.

Zoetis, Inc., Veterinary Medicine Research and Development, Kalamazoo, MI, 49007, USA.

Amitraz is an acaricide and insecticide widely used in agriculture and veterinary medicine. Although central nervous system (CNS) toxicity is one of major toxicities following oral ingestion of amitraz, the understanding of the cause of the toxicity is limited. This study evaluated the systemic and brain exposure of amitraz and its major metabolites, BTS27271, 2',4'-formoxylidide, and 2,4-dimethylaniline following administration of amitraz in male Sprague-Dawley rats. Read More

Environ Toxicol Pharmacol 2019 Jan 23;65:31-39. Epub 2018 Nov 23.

Laboratory for Ecotoxicology - LECOTOX, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg D. Obradovica 2, 21000, Novi Sad, Serbia.

Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Read More

Ecotoxicol Environ Saf 2019 Mar 26;169:623-630. Epub 2018 Nov 26.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, PR China; Institute of Environment and Health, Jianghan University, Wuhan 430056, PR China. Electronic address:

Environmentally persistent free radicals (EPFRs) in atmospheric fine particulate matters (PM) possess high bioactivity and result in severe health problems. The facile transformation of aromatic pollutants into EPFRs on montmorillonite (MMT), an important solid component in PM, is an activation of air pollutants into more toxic chemical species and also attributes to the secondary source of EPFRs in PM. In this study, the interfacial reactions of pentachlorophenol (PCP), a typical EPFR precursor in air pollution, on the Fe(III)-, Ca- and Na-MMT surfaces have been explored by the density functional theory (DFT) calculations using the periodic slab models. Read More

Nat Commun 2018 11 26;9(1):4982. Epub 2018 Nov 26.

MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, W2 1PG, UK.

Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Read More

PLoS Negl Trop Dis 2018 11 19;12(11):e0006933. Epub 2018 Nov 19.

Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York, United States of America.

Aedes aegypti poses a serious risk to human health due to its wide global distribution, high vector competence for several arboviruses, frequent human biting, and ability to thrive in urban environments. Pyrethroid insecticides remain the primary means of controlling adult A. aegypti populations during disease outbreaks. Read More

Mater Sci Eng C Mater Biol Appl 2019 Jan 13;94:949-964. Epub 2018 Oct 13.

Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.

Linalool is a monoterpene alcohol which occurs naturally in several aromatic plants. The aims of this study are to load Linalool on gold nanoparticles, conjugate the complex with CALNN peptide, and investigate them for in-vitro anticancer activities against breast cancer (MCF-7) cell line. Linalool was obtained with 98% purity while gold nanoparticles and CALNN peptide were chemically synthesized. Read More

Chemosphere 2019 Feb 31;217:383-392. Epub 2018 Oct 31.

Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

To find the adverse effects induced by cypermethrin, the ecotoxicological model copepods Tigriopus japonicus and Paracyclopina nana were exposed under cypermethrin, which is a widely used type-II pyrethroid insecticide in agriculture. Despite its large-scale application as insecticide in agriculture, little information is available on its adverse effects on aquatic invertebrates. In this study, the toxicity of cypermethrin on two copepods was assessed based on life parameters (growth rate and reproduction), oxidative stress and consequent antioxidant enzymatic activities, and gene expression profiles of antioxidants. Read More

Aquat Toxicol 2019 Jan 24;206:1-13. Epub 2018 Oct 24.

Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. Electronic address:

Altered transcription of calcium-dependent signaling cascades involving the ryanodine receptor (RyR) and mechanistic target of rapamycin (mTOR) in response to environmental exposures have been described in model vertebrates, including zebrafish, while the relevance for wild fishes remains unknown. To address this knowledge gap, we exposed the euryhaline model species Menidia beryllina (inland silversides) to the insecticide bifenthrin, a known modulator of calcium signaling. The main objectives of this study were to determine: (1) whether exposure of developing silversides to environmentally relevant concentrations of bifenthrin alters their behavior; and (2) whether behavioral changes correlate with altered expression of genes involved in RyR and mTOR-dependent signaling pathways. Read More

Biomed Res Int 2018 9;2018:6257860. Epub 2018 Oct 9.

Laboratório de Mosquitos Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Brazil.

Background: Chemical control is still a major strategy to constrain vector density and mitigate pathogen transmission. However, insecticide overuse poses a high selective pressure, favouring the spread of resistance alleles in natural populations. In an insecticide-free environment, a fitness cost is expected in resistant insects when compared to susceptible counterparts. Read More

Regul Toxicol Pharmacol 2018 Dec 27;100:127-133. Epub 2018 Oct 27.

Department of Zoology, University of Lucknow, Lucknow, 226007, UP, India. Electronic address:

A comparative toxicity assessment was performed to evaluate the effect of cypermethrin nanoparticles (CypNPs) and cypermethrin (Cyp) on murrel, Channa punctatus. Size variation and shape morphology of nanoparticles were confirmed by scanning electron microscopy, UV-Vis absorption spectroscopy and transmission electron microscopy. CypNPs presented shoulder band at a wavelength of 277 nm and size range between 29. Read More

Parasit Vectors 2018 Nov 3;11(1):573. Epub 2018 Nov 3.

UNIDEF-CITEDEF-CONICET- CIPEIN, Juan B. de La Salle 4397, (1603) Villa Martelli, Buenos Aires, Argentina.

Background: Eugenol is a botanical monoterpene that hyperactivates the blood-sucking bug Triatoma infestans, and permethrin is a pyrethroid with a strong triatomicide effect. In the present work, we tested the hypothesis that eugenol-hyperactivated nymphs of T. infestans pick up more insecticide, and then become intoxicated faster, than non-hyperactivated nymphs when exposed to a permethrin-treated surface. Read More

Toxicol Lett 2019 Feb 30;301:34-41. Epub 2018 Oct 30.

Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR - Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, India. Electronic address:

Some districts of Bihar, especially Muzzaffarpur district, have been known to be affected by annual outbreak, called locally as Acute Encephalitis Syndrome (AES) which became one of the major health concerns in Bihar, due to its high fatality and complications. Several hypotheses like bat virus, heat stroke, pesticide exposure and the presence of a compound - methylenecyclopropyl glycine (MCPG) in Litchi have been proposed by different investigators for AES. When the investigators examined the symptoms, signs and the epidemiological data, bat virus and heat stroke hypothesis were ruled out. Read More

Environ Pollut 2019 Jan 22;244:747-756. Epub 2018 Oct 22.

Department of Biology, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. Electronic address:

The correlation between endocrine active contaminants in the environment and alterations in reproductive development of Sarotherodon melanotheron from Lagos lagoon has been investigated. Sediment and a total of 155 fish (74 males and 81 females) were collected between November 2014-March 2015 from selected contaminated sites (Ikorodu, Oworonshoki, Makoko and Idumota) and a putative control site (Igbore) along the lagoon. Sediment contaminant analysis revealed, significantly higher concentration of lindane, dieldrin, 4-iso-nonylphenol, 4-t-octylphenol and monobutyltin cation at the contaminated sites. Read More

Sci Total Environ 2019 Feb 16;652:780-787. Epub 2018 Oct 16.

Agro-Environmental Research Institute, National Agricultural Research and Innovation Centre, Herman O. u. 15, H-1022 Budapest, Hungary. Electronic address:

Substance losses of linear alkylbenzene sulfonates (LASs) in a neat surfactant mixture, in an insecticide formulation Mospilan 20 SG, and in solutions with different neonicotinoid active ingredients (AIs) was studied in distilled water and in surface water samples originated from River Danube. Analytical measurements were performed both by HPLC-UV and commercial ELISA methods. Loss rates of LASs were found different in these aqueous matrices, with decomposition rates higher for the neat surfactant mixture than for Mospilan 20 SG (nearly 2- and 9-fold in distilled water and in surface water from River Danube, respectively). Read More

Ecotoxicol Environ Saf 2019 Jan 24;167:435-440. Epub 2018 Oct 24.

School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300, China. Electronic address:

Plant allelochemicals effectively inhibit and/ or control algal growth, and have potential to use as algaecide. To uncover the lethal mechanism of 2 anti-algal compounds linalool and α-terpineol identified from Cinnamomum camphora extracts, and promote their development as algaecide, the HO production, photosynthetic abilities, caspase-like activities, nuclear changes and DNA degradation were investigated in Chlamydomonas reinhardtii treated with the 2 compounds. HO content burst in linalool treatment at 0. Read More

Chemosphere 2019 Feb 16;216:69-74. Epub 2018 Oct 16.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China. Electronic address:

Numerous studies suggested that reptiles are sensitive to environmental pollution and the abundance of many species are in decline. Our research is aim to assess the toxic effects of pesticide in reptiles. And we also want to supply some data about nondestructive samples for environmental risk assessment in reptiles. Read More

PLoS Negl Trop Dis 2018 10 24;12(10):e0006544. Epub 2018 Oct 24.

Mosquito and Fly Research Unit, United States Department of Agriculture, Agricultural Research Service, Center for Medical, Agricultural, and Veterinary Entomology, Gainesville, FL, United States of America.

Recent outbreaks of locally transmitted dengue and Zika viruses in Florida have placed more emphasis on integrated vector management plans for Aedes aegypti (L.) and Aedes albopictus Skuse. Adulticiding, primarily with pyrethroids, is often employed for the immediate control of potentially arbovirus-infected mosquitoes during outbreak situations. Read More

Environ Sci Pollut Res Int 2018 Dec 15;25(34):34730-34739. Epub 2018 Oct 15.

School of Environmental Sciences, Ontario Agricultural College, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

In this study, honey bees (Apis mellifera L.) were exposed to LD and LD doses of five commonly used acaricides for controlling the parasitic mite, Varroa destructor. LD values at 48 h post-treatment showed that tau-fluvalinate was the most toxic, followed by amitraz, coumaphos, thymol, and formic acid. Read More

Environ Sci Pollut Res Int 2018 Dec 11;25(34):34510-34518. Epub 2018 Oct 11.

Department of Chemistry, School of Physical Sciences, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.

Production and use of most organochlorine pesticides (OCPs) was banned through the Stockholm Convention on persistent organic pollutants. However, appreciable amounts are still detected in the environment due to their persistence, illegal use, and releases from contaminated soils and obsolete stocks. The present study investigated the levels of OCP residues in Nairobi River. Read More

Cell Mol Biol (Noisy-le-grand) 2018 Sep 30;64(12):11-14. Epub 2018 Sep 30.

Department of Elementary Education, Faculty of Education, Siirt University, Siirt, Turkey.

The worldwide increase in the rate of cancer incidence also leads to a significant increase in the use of chemotherapeutic agents. Unfortunately, the optimal clinical usefulness of these agents is heavy restricted by a high incidence of several organ toxicity and as well reason oxidative stress and bring about changing in antioxidant status. Kidney toxicity is a side effect often encountered with cyclophosphamide (CPM) which is commonly used in most cancer chemotherapy. Read More

Environ Pollut 2018 Dec 25;243(Pt B):1588-1601. Epub 2018 Sep 25.

University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Hofackerstrasse 30, CH-4132, Muttenz, Switzerland; Swiss Federal Institute of Technology Zürich (ETH Zürich), Department of Environmental System Sciences, Institute of Biogeochemistry and Pollution Dynamics, CH-8092, Zürich, Switzerland. Electronic address:

Exposure to plant protection products (PPPs) is one of the causes for the population decline of pollinators. In addition to direct exposure, pollinators are exposed to PPPs by pollen, nectar and honey that often contain residues of multiple PPPs. While in legislation PPPs are regarded mainly for their acute toxicity in bees, other effects such as neurotoxicity, immunotoxicity, behavioural changes, stress responses and chronic effects that may harm different physiologically and ecologically relevant traits are much less or not regarded. Read More

Toxicol Lett 2018 Dec 4;299:124-128. Epub 2018 Oct 4.

Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, Campus Lagoas Marcosende, 36310 Vigo, Spain.

Paraoxon (POX) is an extremely neurotoxic organophosphorous compound (OP) which main toxic mechanism is the irreversible inhibition of cholinesterase. Although the cholinergic system has always been linked as responsible for its acute effects, experimental studies have suggested that the dopaminergic system also may be a potential target for OPs. Based on this, in this study, the acute intrastriatal effects of POX on dopaminergic neurotransmission were characterized in vivo using brain microdialysis in freely moving rats. Read More

Sci Total Environ 2019 Feb 25;650(Pt 2):2063-2073. Epub 2018 Sep 25.

Department of Zoology, Science College, King Saud University, Riyadh 11451, Saudi Arabia.

Fipronil (FPN), a commonly used phenylpyrazole pesticide can induce oxidative tissue damage following hazard usage. Due to the extensive household and commercial usage of FPN, its toxic effects on mammals received considerable attention. Finding the proper antioxidant that can overcome FPN-induced damage is essential. Read More

Toxicol Lett 2018 Dec 1;299:129-136. Epub 2018 Oct 1.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F 35000, Rennes, France. Electronic address:

Chlordecone is an organochlorine used in the 1970's as a pesticide in banana plantations. It has a long half-life in the soil and can potentially contaminate humans and animals through food. Chlordecone targets, and mainly accumulates in, the liver, leading to hepatomegaly and neurological signs in mammals. Read More

Chemosphere 2018 Dec 4;212:1085-1094. Epub 2018 Sep 4.

Institute of Environment and Ecology, Shandong Normal University, Ji'nan, 250014, People's Republic of China. Electronic address:

The electrocardiogram (ECG) has been widely used to objectively address the physical condition as an index of stress. Though a numerous accounts of investigations on aquatic organisms' ECGs have been made, differentiation of ECG parameters in responding to specific toxic chemicals has not been extensively studied. In this research, it is hypothesized that zebrafish (Danio rerio) ECG parameters would differently respond to different types of pollutants, a heavy metal, thallium (Tl, 0. Read More

Environ Sci Pollut Res Int 2018 Nov 3;25(32):31793-31798. Epub 2018 Oct 3.

International HCH and Pesticides Association, Elmevej 14, DK-2840, Holte, Denmark.

Chemosphere 2019 Jan 25;214:519-533. Epub 2018 Sep 25.

Department of Agriculture, University of Swabi, Swabi, 23561, Khyber Pakhtunkhwa, Pakistan. Electronic address:

Deltamethrin (DLM) is α-cyano (type II) synthetic pyrethroid. DLM exposure leads to strong neurotoxic effects and a number of complex toxicological syndromes. The current study assessed DLM mediated oxidative stress, behavioral, hematological, histopathological, and biochemical toxic effects on silver carp (Hypophthalmichthys molitrix). Read More

Bioelectrochemistry 2019 Feb 17;125:71-78. Epub 2018 Sep 17.

Institute of Environmental Biology and Life Support Technology, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing 100191, China.

The relatively poor sensitivity is the main bottleneck restricting the application of microbial fuel cell biosensor (MFC-biosensor) for toxicity monitoring. Previous studies have shown that external resistance (R) had an obvious effect on sensor sensitivity. However, these studies reported different results and the reason of this discrepancy was not clear. Read More

Chem Biol Interact 2018 Dec 27;296:105-116. Epub 2018 Sep 27.

Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

Exposure to pesticide chlorpyrifos (CPF) is associated with neurodevelopmental toxicity both in humans and animals. Diphenyl diselenide (DPDS) is a simple synthetic organoselenium well reported to possess antioxidant, anti-inflammatory and neuroprotective effects. However, there is paucity of information on the beneficial effects of DPDS on CPF-mediated brain injury and neurobehavioural deficits. Read More

Environ Mol Mutagen 2019 01 27;60(1):72-84. Epub 2018 Sep 27.

Unit of Mutagenesis, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Chlorpyrifos, imidacloprid, and α-cypermethrin are some of the most widely used insecticides in contemporary agriculture. However, their low-dose, nontarget genotoxic effects have not been extensively assayed. As one of the most relevant cancer biomarkers, we aimed to assess the aneuploidy due to chromosome missegregation during mitosis. Read More

Food Chem Toxicol 2018 Nov 22;121:573-582. Epub 2018 Sep 22.

UR 1264 MycSA, INRA, Centre INRA de Nouvelle Aquitaine - Bordeaux, 71 av Edouard Bourlaux, 33140, Villenave d'Ornon, France.

We analyzed a comprehensive set of contaminants in MON810 and NK603 genetically modified (GM) maize, and their non-GM counterparts, used in a rat feeding study (the GMO90 + project). Both the maize grains and the manufactured pellets were characterized. Only minor differences in contaminant levels between GM and corresponding non-GM harvests were evidenced. Read More

Toxicol In Vitro 2019 Feb 22;54:98-104. Epub 2018 Sep 22.

Department of Biochemistry, Maulana Azad Medical College, 2 Bahadur Shah Zafar Marg, New Delhi 110002, India.. Electronic address:

Lindane exposure is claimed to be involved in pathogenesis of type 2 diabetes mellitus (T2DM) and insulin resistance state by an as yet unknown mechanism. The redox sensitive kinases (RSKs) and heat shock proteins (HSPs) interfere with insulin signaling and induce insulin resistance. The present study was designed to explore the mechanism of insulin resistance induced by sub-toxic lindane exposure. Read More

Environ Pollut 2018 Dec 14;243(Pt B):809-814. Epub 2018 Sep 14.

Department of Animal Biology, Federal University of Viçosa, Viçosa, MG 36570-000, Brazil. Electronic address:

Leaf-cutting ants are important pests of forests and agricultural crops in the Neotropical region. Atta sexdens colonies can be composed of thousands of individuals, which form a highly complex society with a single reproductive queen. Successful control of this species is achieved only if the queen is affected. Read More

Ecotoxicol Environ Saf 2018 Dec 19;166:26-34. Epub 2018 Sep 19.

Centre for Ecology and Hydrology, Maclean Building, Benson Lane, Wallingford Oxfordshire OX10 8BB, UK; Institute of Environmental Sciences, University of Leiden, P.O. Box 9518, 2300 RA Leiden, the Netherlands.

Daphnia magna were exposed to two pesticides in the presence or absence of microplastics (300 000 particles ml 1 µm polystyrene spheres) and to microplastics alone. The pesticides were dimethoate, an organophosphate insecticide with a low log Kow, and deltamethrin, a pyrethroid insecticide with a high log Kow. Daphnia were exposed to a nominal concentration range of 0. Read More

Environ Sci Pollut Res Int 2018 Nov 21;25(32):32582-32590. Epub 2018 Sep 21.

Parasitology Department, Theodore Bilharz Research Institute, Giza, Egypt.

Several formulated mixtures of pesticides are widely used in modern agriculture. Nevertheless, the agriculture runoff causes a serious damage to the aquatic ecosystem. Therefore, the present study aims to use B. Read More

Toxicol Lett 2018 Dec 18;299:47-55. Epub 2018 Sep 18.

Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, United States. Electronic address:

Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative toxicity in the rat N27 dopaminergic neuronal cells through increased oxidative stress and mitochondrial dysfunction. In this study, we investigated the involvement of NADPH oxidase (NOX) proteins in the combined treatment with dieldrin and lindane-induced dopaminergic neurotoxicity. Read More

Parasit Vectors 2018 Sep 20;11(1):515. Epub 2018 Sep 20.

Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Ratchadewee, Bangkok, 10400, Thailand.

Background: Mosquitoes transmit many vector-borne infectious diseases including malaria, dengue, chikungunya, yellow fever, filariasis, and Japanese encephalitis. The insecticidal δ-endotoxins Cry4, Cry11, and Cyt produced from Bacillus thuringiensis have been used for bio-control of mosquito larvae. Cry δ-endotoxins are synthesised as inactive protoxins in the form of crystalline inclusions in which they are processed to active toxins in larval midgut lumen. Read More

Ecotoxicol Environ Saf 2018 Dec 13;165:476-483. Epub 2018 Sep 13.

Zhejiang Academy of Agricultural Sciences Institute of Agricultural Products Quality Standard, 198 Shiqiao Road, Hangzhou, Zhejiang 310021, PR China.

Systematically evaluation of the metabolism, distribution and effect of imidacloprid in Chinese lizards (Eremias argus) were carried out following oral exposure. Imidacloprid-olefin-guanidine was prone to accumulate in the brain and caused potential neurotoxicity. Percutaneous and excretory excretions were the primary ways for the elimination of imidacloprid and its metabolites. Read More

Nanoscale 2018 Oct;10(38):18205-18216

911 Hergot Avenue, Ruston, LA 71272, USA.

While most hair care formulations are developed on the basis of surfactants or polymers, we introduce self-assembly coating of micro and nanoparticles as the underlying principle for hair modification, protection and enhancement. Halloysite clay nanotubes formed by rolled sheets of aluminosilicate kaolin assemble on the surface of hair forming a robust multilayer coverage. Prior to the application, clay nanotubes were loaded with selected dyes or drug allowing for hair coloring or medical treatment. Read More

Chemosphere 2018 Nov 23;210:958-967. Epub 2018 Jul 23.

Laboratório de Ecofisiologia Animal, Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Paraná, Brazil.

The λ-cyhalothrin (CL) is a globally used pyrethroid insecticide that has been detected in different water bodies worldwide. However, studies on the effects of CL on freshwater fishes are still incipient. In this context, we evaluated the acute effects of a commercial formulation containing CL (Karate Zeon CS 50) in juveniles of the teleost Prochilodus lineatus exposed for 96 h to four concentrations of the active ingredient (5, 50, 250 and 500 ng. Read More

Chem Commun (Camb) 2018 Sep;54(76):10754-10757

School of Chemical Engineering and Technology, Hebei University of Technology, 8 Guangrong Road, Hongqiao District, Tianjin, 300130, P. R. China.

An integrated nanocatalyst (INC), denoted OPH@MIL-100(Fe), was synthesized by immobilizing a biocatalyst onto a metal-organic framework (MOF)-based catalyst, which can cascadingly degrade organophosphate nerve agents to 4-aminophenol (4-AP) and result in a sharp decrease of their toxicity up to 208-fold. Read More

Environ Sci Pollut Res Int 2018 Nov 5;25(31):31165-31174. Epub 2018 Sep 5.

Medicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil.

Zika, dengue, and chikungunya are vector-borne diseases of pronounced concern transmitted by the mosquito Aedes aegypti Linn. (Diptera: Culicidae). The most important method to avoid outbreaks is to control mosquito spreading by the employment of insecticides and larvicides. Read More

Biomed Res Int 2018 8;2018:3895834. Epub 2018 Aug 8.

Laboratory of Biopesticides, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia.

The increasing insect resistance against delta-endotoxins is a serious problem which makes it urgent to look for new eco-friendly strategies. Combining these toxins with other biomolecules is one of the promising strategies against insect pests. In this work, we evaluated the bioinsecticidal potential of extracts and strain BLB250 against (Lepidoptera: Noctuidae) larvae. Read More

Environ Sci Pollut Res Int 2018 Oct 1;25(30):30597-30608. Epub 2018 Sep 1.

Department of Physiology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar despota Stefana 142, Belgrade, 11060, Serbia.

Pesticide-induced oxidative stress, as one of mechanism of toxicity, has been a focus of toxicological research. However, there is a lack of data for certain pesticides-oxidative stress effects especially on terrestrial amphibians. This study evaluates the prooxidative effects of orally administered insecticide deltamethrin (DM) in some tissues of the terrestrial toad Bufotes viridis. Read More

Chemosphere 2018 Dec 27;212:629-637. Epub 2018 Aug 27.

Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brazil. Electronic address:

Insecticides used in the agriculture and forestry have side effects on non-target organisms used as natural enemies. This study evaluated the histopathology and cytotoxicity of permethrin on the midgut of the non-target predatory bug, Podisus nigrispinus (Heteroptera: Pentatomidae) used in the biological control of pest insects. The toxicity and survival of this insect were determined using six concentrations of permethrin via ingestion. Read More