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Pestic Biochem Physiol 2020 Jun 23;166:104565. Epub 2020 Mar 23.

College of Plant Science, Jilin University, Changchun 130062, PR China; School of Agricultural Science, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze the conjugation of small lipophilic endogenous and exogenous compounds with sugars to produce water-soluble glycosides, playing an important role in insect endobiotic regulation and xenobiotic detoxification. In this study, two UGT-inhibitors, sulfinpyrazone and 5-nitrouracil, significantly increased spirotetramat toxicity against third instar nymphs of resistant Aphis gossypii, whereas there were no synergistic effects in apterous adult aphids, suggesting UGT involvement in spirotetramat resistance in cotton aphids. Furthermore, the UHPLC-MS/MS was employed to determine the content of spirotetramat and its four metabolites (S-enol, S-glu, S-mono, S-keto) in the honeydew of resistant cotton aphids under spirotetramat treatment. Read More

Pestic Biochem Physiol 2020 Jun 6;166:104562. Epub 2020 Mar 6.

Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, UK. Electronic address:

The buff-tailed bumblebee, Bombus terrestris audax is an important pollinator within both landscape ecosystems and agricultural crops. During their lifetime bumblebees are regularly challenged by various environmental stressors including insecticides. Historically the honey bee (Apis mellifera spp. Read More

Chemosphere 2020 Sep 27;255:126910. Epub 2020 Apr 27.

MGI of Shanghai University, Xiapu Town, Xiangdong District, Pingxiang City, Jiangxi, 337022, PR China; SHU Center of Green Urban Mining & Industry Ecology, School of Environmental and Chemical Engineering, Shanghai University, No. 381 Nanchen Road., Shanghai, 200444, PR China.

In particulate matter, organic precursors generate environmentally persistent free radicals (EPFRs) on metal oxides and attract worldwide attentions in health risk assessment and environmental protection. For the first time, we determined characteristics and formation processes of EPFRs evolved from different organic precursors on PbO particulate. As a result, phenol resulted in phenoxyl radical at 230 °C by releasing one H atom. Read More

Pestic Biochem Physiol 2020 May 5;165:104559. Epub 2020 Mar 5.

Instituto de Investigaciones Bioquímicas de La Plata "Profesor Doctor Rodolfo R. Brenner", 60 y 120 s/n, La Plata, Buenos Aires, Argentina. Electronic address:

Spiders are found among the most important predators of plague insects of numerous agricultural systems. They are the most numerous representatives of the Class Arachnid and are widely distributed in numerous ecosystems. Due to multiple variables, living beings are exposed to quantitative transitions of their energetic reserves, which affect their sensitivity before the different xenobiotics. Read More

Pestic Biochem Physiol 2020 May 30;165:104463. Epub 2019 Oct 30.

University of Carthage, Environmental Biomonitoring Laboratory (LBE), Faculty of Sciences of Bizerte, Zarzouna 7021, Tunisia.

Cypermethrin (Cyp) is a kind of pyrethroids compound that is broadly used against different species of insects and pests. Cyp can also elicit a range of neurotoxic, immunotoxic, genotoxic and reproductive toxic effects on various experimental organisms. The aim of this study was to evaluate the protective effects of Hibiscus sabdariffa against the toxicity damage induced by Cyp exposure. Read More

Pestic Biochem Physiol 2020 May 19;165:104547. Epub 2020 Feb 19.

School of Public Health, Bengbu Medical College, Bengbu, Anhui 233030, China.

Pesticide residue is a common problem worldwide. Cypermethrin is a type II pyrethroid pesticide that has been widely used in recent years. It has become a widespread residual pesticide in the environment and agricultural products. Read More

Ecotoxicology 2020 May 14;29(4):493-502. Epub 2020 Apr 14.

Facultad de Ciencias, Universidad Autónoma de Baja California, Carretera Transpeninsular Tijuana-Ensenada No. 3917, Fraccionamiento Playitas, CP 22860, Ensenada, Baja California, Mexico.

The environmental exposure to As, Se, Hg, Pb, Cr and toxaphene was assessed for 11 freshwater fish species in irrigation channels, agricultural return flow drains, a drain collecting lagoon and sections of the Colorado River at the Mexicali valley in Baja California, México, during August 2015-April 2016. Arsenic (2.90 ng ml) and Se (1. Read More

Pestic Biochem Physiol 2020 Mar 31;164:85-90. Epub 2019 Dec 31.

Department of Molecular Physiology, Agricultural Biotechnology Research Institute of Iran | ABRII, Karaj, Iran.

Pyridalyl is one of the recently discovered insecticides which has shown toxicity against several insect pests with slight- or non-lethal effects against natural enemies. Cytotoxicity and prevention of protein synthesis have been reported as pyridalyl mode of action. In the current study, adults of Bacterocera oleae, as a major pest of olive, were fed on protein hydrolysate diet containing LC concentration of pyridalyl to determine the possible mode of action through gene expression and amino acid profile. Read More

Pestic Biochem Physiol 2020 Mar 1;164:221-227. Epub 2020 Mar 1.

Department of Life Sciences & Convergence Research Center for Insect Vectors, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea. Electronic address:

τ-Fluvalinate (fluvalinate) is a highly selective pyrethroid insecticide compound used for controlling ectoparasitic mites that cause major damages in honey bee colonies. Although honey bees have resistance and low toxicity to this xenobiotic chemical, little is known about the effects of this chemical on sensory modulation and behaviors in honey bees. Here we addressed the effect on olfactory cognition at the behavioral, molecular, and neurophysiological levels. Read More

Pestic Biochem Physiol 2020 Mar 23;164:191-195. Epub 2020 Jan 23.

Academy of Agricultural Sciences, Southwest University, Chongqing 400716, China; College of Plant Protection, Southwest University, Chongqing 400716, China. Electronic address:

The γ-aminobutyric acid receptor (GABAR) has been identified as a target site of some commonly used insecticides. Our pervious study documented an interesting phenomenon, i.e. Read More

Chemosphere 2020 Aug 31;253:126629. Epub 2020 Mar 31.

Center for Health and the Environment, USA; Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA. Electronic address:

Recent reports demonstrate that octopamine receptor (OR) agonists such as formamidine pesticides cause reproductive and developmental toxicity through endocrine disrupting effects in both humans and animals. Herein, we studied the effects of different sublethal concentrations of OR agonists, Amitraz and Chlordimeform, on growth, development, and reproduction of D. melanogaster from a genotype perspective view. Read More

Chemosphere 2020 Aug 1;253:126635. Epub 2020 Apr 1.

College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China. Electronic address:

Carbofuran, a carbamate pesticide, is widely used in developing countries to manage insect pests. Studies have found that carbofuran posed potential risks for the neurotransmitter systems of non-target species, we speculated that these disruptive effects on the neurotransmitter systems could trigger anxiety-like behaviors. In this study, female zebrafish were exposed to environmental levels (5, 50, and 500 μg/L) of carbofuran for 48 h to evaluate the effects of carbofuran on anxiety-like behaviors. Read More

Chemosphere 2020 Jun 17;249:126536. Epub 2020 Mar 17.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academic of Science, Wuhan, 430072, China.

This study investigated the influences of titanium dioxide nanoparticles (n-TiO) on the thyroid endocrine disruption and neurobehavioral defects induced by pentachlorophenol (PCP) in zebrafish (Danio rerio). Embryos (2 h post-fertilization) were exposed to PCP (0, 3, 10, and 30 μg/L) or in combination with n-TiO (0.1 mg/L) until 6 days post-fertilization. Read More

Chemosphere 2020 Jun 16;249:126479. Epub 2020 Mar 16.

Tobacco Research Institute of Chinese Academy of Agricultural Sciences (CAAS), Qingdao, 266101, PR China. Electronic address:

As part of a new generation of diamide insecticides, cyantraniliprole has broad application prospects. In the present study, a QuEChERS-UPLC-MS/MS method was established to determine the residues of cyantraniliprole and its main metabolite J9Z38 in soil and earthworms. Moreover, the accumulation and toxicity of cyantraniliprole and J9Z38 in earthworms were evaluated. Read More

Ecotoxicol Environ Saf 2020 Jun 19;195:110460. Epub 2020 Mar 19.

Centro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, 2060, San José, Costa Rica. Electronic address:

Biopurification systems (BPS) or biobeds have been developed to attenuate point-source contamination due to inappropriate pesticide handling or disposal of agricultural wastewaters. The biomixture used for this strategy should be able to remove different active ingredients but its efficiency can vary due to the constant load of pesticides from crop application programs. For that reason, the performance of biomixtures in conditions that mimic the real pesticide treatment before their implementation in field settings should be assayed. Read More

Ecotoxicol Environ Saf 2020 Jun 1;195:110479. Epub 2020 Apr 1.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Cypermethrin (CYP), a class II synthetic pyrethroid, is used to control household insects. CYP can cross the blood-brain barrier to exert neurotoxicity through changes in sodium ion channels. Selenium is an essential component of glutathione peroxidise enzyme; in addition, it shows a potential anti-inflammatory property. Read More

Ecotoxicology 2020 May 20;29(4):407-416. Epub 2020 Mar 20.

Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.

The chive maggot, Bradysia odoriphaga (Yang and Zhang) is an economically important insect pest, affecting many key vegetables, including Chinese chive, especially in northern China. Chlorfenapyr, a halogenated pyrrole insecticide that interferes with mitochondrial oxidative phosphorylation is widely used against B. odoriphaga. Read More

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Jul;32(1):69-72

Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Jining 272033, China.

Objective: To explore the sensitivity of to common chemical insecticides in the southwestern region of Shandong Province, so as to provide a theoretical basis for the development of reasonable and effective mosquito control measures.

Methods: The resistance of larvae to 5 chemical insecticides, such as cypermethrin, deltamethrin, DDVP, propoxur, and acetofenate were tested by using the WHO biological test method in 2018, and the co-toxicity coefficients after compounding the above-mentioned insecticides were tested by using a drug compounding method.

Results: The resistance indexes of to cypermethrin, deltamethrin, DDVP, propoxur, and acetofenate in 3 cities were 144. Read More

Ecotoxicol Environ Saf 2020 Jun 14;195:110467. Epub 2020 Mar 14.

Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, PR China. Electronic address:

Heavy metals and pesticides can be easily enriched in food chains and accumulated in organisms, thus pose significant threat to human health. However, their combined effects for long-term exposure at low dose has not been thoroughly investigated; especially there was no biofluid biomarker available to noninvasively diagnose the toxicosis of the combined exposure of the two chemicals at their low levels. In this study, we investigated the change of urine metabolites of rats with 90-day exposure to heavy metal cadmium (Cd) and/or organophosphorus pesticide chlorpyrifos (CPF) using gas chromatography-mass spectrometry (GC-MS)-based metabolomics approach. Read More

Chemosphere 2020 Aug 7;252:126433. Epub 2020 Mar 7.

Laboratorio de Ecología Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral) UNL - CONICET, Esperanza, Argentina; Laboratorio de Genética, Departamento de Ciencias Naturales (FHUC - UNL), CONICET, Santa Fe, Argentina. Electronic address:

Different studies have demonstrated effects of pesticides during embryo development in vertebrates and stage-dependent effects, but there is no information concerning this for Salvator merianae. We evaluated the effects of the herbicides Glyphosate Roundup (GLY-RU) and Glyphosate Panzer Gold (GLY-PZ); and the insecticides Chlorpyrifos (CPF) and Cypermethrin (CYP), and their complex mixtures, at different concentrations in hematological parameters of S. merianae embryos at two different development stages. Read More

PLoS Negl Trop Dis 2020 03 16;14(3):e0007753. Epub 2020 Mar 16.

Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Department of Microbiology, Immunology and Pathology, Arthropod Borne and Infectious Diseases Laboratory, Campus Delivery, Fort Collins, Colorado, United States of America.

Background: Resistance to pyrethroid insecticides in Aedes aegypti has become widespread after almost two decades of the frequent use of these pesticides to reduce arbovirus transmission. Despite this resistance, pyrethroids continue to be used because they are relatively inexpensive and have low human toxicity. Resistance management has been proposed as a way to retain the use of pyrethroids in natural populations. Read More

Chemosphere 2020 Jul 6;251:126426. Epub 2020 Mar 6.

Department of Pharmacology and Toxicology, Medicine School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address:

Organophosphate biocide chlorpyrifos (CPF) is involved with breast cancer. However, the mechanisms remain unknown. CPF increases cell division in MCF-7 cells, by estrogen receptor alpha (ERα) activation, although it is a weak ERα agonist, suggesting other mechanisms should be involved. Read More

Chemosphere 2020 Jul 25;250:126321. Epub 2020 Feb 25.

Key Laboratory of Pesticide Toxicology and Application Technique, College of Plant Protection, Shandong Agricultural University, Tai'an, China. Electronic address:

The lacewing, Chrysoperla sinica, is an important predatory insect, which plays an important role in the integrated pest management of agroforestry pests. However, the extensive use of insecticides negatively affects C. sinica. Read More

Ecotoxicology 2020 Apr 2;29(3):286-294. Epub 2020 Mar 2.

Environmental Safety Group, KIST Europe, Korea Institute of Science and Technology, Campus E7.1, 66123, Saarbrücken, Germany.

Pentachlorophenol (PCP) is a widespread and persistent hydrophobic organic pollutant in the environment despite its restricted public use. Risk assessment of such hydrophobic organic compounds (HOCs) is challenging because sorption and volatilization issues during toxicity test often lead to inconsistent exposure concentration. Considering the hydrophobicity of the PCP, in this study, a passive dosing format was applied by adopting a silicone O-ring as a reservoir and evaluated its applicability on the determination of PCP on Daphnia magna. Read More

Aquat Toxicol 2020 May 18;222:105453. Epub 2020 Feb 18.

Burridge Consulting Inc., 61 Emmalee Dr Stratford PE, Canada C1B 0B5, Canada. Electronic address:

Anti-parasitic drugs used in the aquaculture industry are discharged to the sea after treatment of salmon. In this study, the effects of azamethiphos (AZA) in the Salmosan® formulation and deltamethrin (DEL) in the Alpha Max® formulation, have been assessed in Northern shrimp larvae (Pandalus borealis) when administered both separately and in combination. The exposure concentrations were 100 ng/L for AZA and 2 ng/L for DEL, each representing a 1000-fold dilution of the prescribed concentrations for salmon. Read More

Ecotoxicology 2020 Apr 27;29(3):327-339. Epub 2020 Feb 27.

Department of Crop Protection, Federal University of Pelotas (UFPel), Postal Code 354, Capão do Leão, Pelotas, Rio Grande do Sul State, 96010-900, Brazil.

Chrysoperla externa and Coleomegilla quadrifasciata are important biological control agents in peach orchards. However, orchard management with these predatory insects is viable only by using selective agrochemicals. The objective of this study is to evaluate the toxicity of nine agrochemicals used in peach orchards in larval and adult stages of the C. Read More

Ecotoxicol Environ Saf 2020 Apr 24;193:110318. Epub 2020 Feb 24.

Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018, Sfax, Tunisia.

The current study aimed to examine, for the first time, the relationship between exposure to deltamethrin (DLM) and atherogenic lipid profile disorders in adult Wistar rats, as well as, to verify the mechanism of the beneficial role of Zygophyllum album leaves extracts (ZALE). The experimental study was assessed using DLM (4 mg/kg b.w) either alone or co administered with ZALE (400 mg/kg b. Read More

PLoS Negl Trop Dis 2020 02 26;14(2):e0008073. Epub 2020 Feb 26.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America.

The Aedes aegypti mosquito serves as a major vector for viral diseases, such as dengue, chikungunya, and Zika, which are spreading across the globe and threatening public health. In addition to increased vector transmission, the prevalence of insecticide-resistant mosquitoes is also on the rise, thus solidifying the need for new, safe and effective insecticides to control mosquito populations. We recently discovered that cinnamodial, a unique drimane sesquiterpene dialdehyde of the Malagasy medicinal plant Cinnamosma fragrans, exhibited significant larval and adult toxicity to Ae. Read More

Chemosphere 2020 Jul 11;250:126151. Epub 2020 Feb 11.

Université de Lorraine, INRAE, USC 340, UR AFPA, 2 Avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy, France. Electronic address:

The use of chlordecone (CLD), a chlorinated polycyclic pesticide used in the French West Indies banana fields between 1972 and 1993, resulted in a long-term pollution of agricultural areas. It has been observed that this persistent organic pollutant (POP) can transfer from contaminated soils to food chain. Indeed, CLD is considered almost fully absorbed after involuntary ingestion of contaminated soil by outdoor reared animals. Read More

Chemosphere 2020 Jun 7;249:126148. Epub 2020 Feb 7.

Department of Internal Medicine, Texas Tech University of Health Science Centre, Lubbock, 79413, TX, USA. Electronic address:

Cypermethrin is one of the widely used type-II pyrethroid and the indiscriminate use of this pesticide leads to life threatening effects and in particular showed developmental effects in sensitive populations such as children and pregnant woman. However, the molecular mechanisms underlying cypermethrin-induced development toxicity is not well defined. To address this gap, the present study was designed to investigate the phenotypic and transcriptomic (next generation RNA-Seq method) impact of cypermethrin in zebrafish embryos as a model system. Read More

J Agric Food Chem 2020 Mar 26;68(10):3061-3070. Epub 2020 Feb 26.

Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32610, United States.

Pyrethroids are one of the most commonly used classes of insecticides, and their acid and alcohol components are esterase degradation products, usually considered to be biologically inactive. In this study, it was found that several pyrethroid acids had a spatial repellent activity that was greater than DEET, often more active than the parent pyrethroids, and showed little cross resistance in a pyrethroid-resistant Puerto Rico strain of mosquitoes. Further investigation revealed that the acids can synergize not only contact repellent standards but also other pyrethroid components as well as the parent pyrethroids themselves. Read More

Chemosphere 2020 Jun 30;248:126075. Epub 2020 Jan 30.

Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brazil. Electronic address:

The honeybee, Apis mellifera is economically important for its products (honey, wax, and propolis) and for its role in pollination. This insect is threated due to high population losses in both agriculture and beekeeping. Within causes involved in the loss of honeybees is the increased pesticide use on agriculture. Read More

Environ Pollut 2020 Apr 4;259:113715. Epub 2019 Dec 4.

University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Hofackerstrasse 30, CH-4132, Muttenz, Switzerland.

Cypermethrin is a frequently used insecticide in agriculture and households but its chronic and molecular effects are poorly known are . Here we describe effects of sublethal cypermethrin exposure on the global transcriptome in the brain of honey bees determined by RNA-sequencing. Exposure for 48 h to 0. Read More

Ecotoxicol Environ Saf 2020 Mar 29;191:110234. Epub 2020 Jan 29.

State Agriculture Ministry Laboratory of Quality & Safety Risk Assessment for Tobacco, Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, 266101, China.

Imidacloprid is a widely used neonicotinoid insecticide worldwide, and has attracted great concerns due to its potential threat to human and environment. Much effort was thus spent on developing the effective way for removing imidacloprid from water, but might also produce various degradation products with unknown risks. The hypothesis was then proposed that permanganate oxidation was probably the appropriate tool for eliminating imidacloprid and its toxicity through selective oxidation of specific groups. Read More

Environ Sci Pollut Res Int 2020 Apr 1;27(12):13056-13065. Epub 2020 Feb 1.

Department of Phytotechnology and Plant Health, Federal University of Paraná, Curitiba, Parana, Brazil.

The present study aimed to analyze the chemical composition of five species of the genus Piper (P. aduncum L.; P. Read More

Environ Pollut 2020 May 23;260:114059. Epub 2020 Jan 23.

Instituto Español de Oceanografía, IEO, Centro Oceanográfico de Vigo, Subida a Radio Faro 50, 36390, Vigo, Spain.

Ingestion of microplastics by marine organisms has been well documented, but their interaction with chemical pollutants has not been sufficiently addressed. The aim of this study was to determine the individual and combined effects of chlorpyrifos (CPF) and polyethylene microplastics (MP) on the survival, fecundity, feeding and egg viability of Acartia tonsa, a calanoid copepod widely distributed in planktonic communities. The median lethal concentration obtained for CPF was higher (LC = 1. Read More

PLoS One 2020 30;15(1):e0228268. Epub 2020 Jan 30.

Department of Entomology, China Agricultural University, Beijing, China.

Fitness is closely associated with the development of pesticide resistance in insects, which determines the control strategies employed to target species and the risks of toxicity faced by non-target species. After years of selections with beta-cypermethrin in laboratory, a strain of housefly was developed that was 684,521.62-fold resistant (CRR) compared with the susceptible strain (CSS). Read More

Chemosphere 2020 Mar 22;243:125416. Epub 2019 Nov 22.

Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, UF Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, University of Florida, Gainesville, FL, 32611, USA. Electronic address:

Esfenvalerate is a pyrethroid insecticide used widely for agricultural and residential applications. This insecticide has been detected in aquatic environments at concentrations that can induce sub-lethal effects in organisms. In this study, zebrafish embryos were used to examine the effects of environmentally-relevant concentrations of esfenvalerate on development and behavior. Read More

Environ Pollut 2020 Apr 23;259:113870. Epub 2019 Dec 23.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin, 150030, China. Electronic address:

Deltamethrin (DLM) is an important member of the pyrethroid pesticide family, and its widespread use has led to serious environmental and health problems. Exposure to DLM causes pathological changes in the liver of animals and humans and can lead to liver fibrosis. However, the mechanism of DLM-induced liver fibrosis remains unclear. Read More

Malar J 2020 Jan 7;19(1):11. Epub 2020 Jan 7.

London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.

Background: Indoor attractive toxic sugar bait (ATSB) has potential as a supplementary vector-control and resistance-management tool, offering an alternative mode of insecticide delivery to current core vector-control interventions, with potential to deliver novel insecticides. Given the high long-lasting insecticidal bed net (LLIN) coverage across Africa, it is crucial that the efficacy of indoor ATSB in combination with LLINs is established before it is considered for wider use in public health.

Methods: An experimental hut trial to evaluate the efficacy of indoor ATSB traps treated with 4% boric acid (BA ATSB) or 1% chlorfenapyr (CFP ATSB) in combination with untreated nets or LLINs (holed or intact), took place at the M'bé field station in central Côte d'Ivoire against pyrethroid resistant Anopheles gambiae sensu lato. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2020 Apr 31;230:108700. Epub 2019 Dec 31.

Wuxi Fisheries College, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China. Electronic address:

Glutathione S-transferases (GSTs) are a multifunctional protein superfamily that can catalyze the detoxification processes in an organism. In the present study, we determined the structure and function of GSTs in Chinese mitten crab (Eriocheir sinensis) by gene cloning, expression, and enzyme activity in order to investigate the metabolic detoxification of GSTs in the hepatopancreas and muscles under three pesticide (trichlorfon, β-cypermethrin and avermectin) stresses. Multiple sequence alignment analysis showed that all the three Es-GST genes possessed N-terminal, and C-terminal domain as well as G-binding sites, while Es-GST2 and Es-GST3 contained Mu-type GST-specific Mu-loop structures. Read More

Environ Sci Pollut Res Int 2020 Mar 31;27(8):7957-7966. Epub 2019 Dec 31.

University of Monastir, Faculty of Dental Medecine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, 5019, Monastir, Tunisia.

The increased use of pesticides is the origin of multiple damages to the environment and to humans; thus, the search for new strategies to reduce or even protect the toxic effects caused by these synthetic products became a necessity. In this context, our study attempted to evaluate the protective effects of fennel essential oil (FEO), the main essential oil extracted from Faeniculum vulgare Mill., a plant with aromatic, flavorful, and medicinal uses, against toxicity induced by an insecticide-triflumuron (TFM)-in human carcinoma cells (HCT116). Read More

Carbohydr Polym 2020 Mar 9;231:115725. Epub 2019 Dec 9.

School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China; Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China. Electronic address:

In order to further enhance hydrophilicity of zein and achieve nano-scale pesticide system, phosphorylated zein (P-Zein) was incorporated with graft copolymer CMC-g-PDMDAAC by electrostatic interaction, in which carboxymethyl cellulose (CMC) and diallyldimethylammonium chloride (DMDAAC) as monomers. P-Zein/CMC-g-PDMDAAC was applied to encapsulate model pesticide avermectin (AVM) via electrostatic interaction to achieve AVM@P-Zein/CMC-g-PDMDAAC nano-pesticides. The stability, drug loading, anti-ultraviolet, adhesion, sustained-release and toxicity of nano-pesticides presented considerable behavior confirmed via various characteristics. Read More

Chemosphere 2020 May 19;246:125691. Epub 2019 Dec 19.

Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) & GTB Hospital, Dilshad Garden, Delhi, 110095, India. Electronic address:

Although the etiology of ovarian cancer is not clear, certain factors are implicated in this disease, such as ovulation, gonadotropic and steroid hormones, growth factors, cytokines, environmental agents, etc. Epidemiological studies have proven environmental exposure to pesticides with an increased risk of Epithelial Ovarian Cancer (EOC); however, the molecular mechanism underlying the carcinogenic effects of pesticides in human ovary remains poorly understood. The present study aimed to study the pro-inflammatory response of organochlorine pesticides (OCPs) namely β-hexachlorocyclohexane (β-HCH), dichlorodiphenyldichloroethylene (DDE) and Dieldrin following exposure to human ovary surface epithelial cells (HOSE) for risk prediction of epithelial ovarian cancer. Read More

Environ Sci Pollut Res Int 2020 Mar 29;27(7):7618-7627. Epub 2019 Dec 29.

Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.

The essential oil (EO) from leaves of Mentha piperita was extracted by hydrodistillation. Twenty-one chemical components, accounting for 97.5% of the total oil, were determined by GC-MS and GC-FID. Read More

Ecotoxicol Environ Saf 2020 Mar 26;190:110129. Epub 2019 Dec 26.

Department of Environmental Engineering, Faculty of Engineering and Research Center for Environmental and Hazardous Substance Management, Khon Kaen University, Khon Kaen, 40002, Thailand; Center of Excellence on Hazardous Substance Management (HSM), Bangkok, 10330, Thailand. Electronic address:

Profenofos insecticide is one of the most broadly used organophosphorus pesticides causing the contamination of soil and groundwater. Since dissolved oxygen concentration in groundwater is limited, this study aimed to investigate profenofos biodegradation and detoxification under aerobic and anoxic conditions using the profenofos-degrading Pseudomonas plecoglossicida strain PF1 (PF1). Anoxic biodegradation under the presence of nitrate was the focus. Read More

Environ Sci Pollut Res Int 2020 Mar 27;27(7):6971-6980. Epub 2019 Dec 27.

Guizhou Institute of Plant Protection, Guizhou Academy of Agricultural Sciences, Guiyang, 550006, Guizhou, People's Republic of China.

Potential synergistic toxicity of pesticide mixtures has increasingly become a concern to the health of crop pollinators. The toxicities of individual and mixture of chlorpyrifos (CHL), acephate (ACE), or tetraconazole (TET) with nine pyrethroid insecticides to honey bees (Apis mellifera L.) were evaluated to reveal any aggregated interaction between pesticides. Read More

Ecotoxicol Environ Saf 2020 Mar 23;190:110106. Epub 2019 Dec 23.

Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Haidian District, Beijing, 100875, China. Electronic address:

In this work, the essential oil (EO) and supercritical CO fluid extract (SF extract) of four Valerianaceae plants (Valeriana officinalis L., Valeriana officinalis L. var. Read More

Ecotoxicol Environ Saf 2020 Mar 23;190:110101. Epub 2019 Dec 23.

Risk Assessment Laboratory for Bee Products Quality and Safety of the Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, 100093, China. Electronic address:

Varroa mites often inflict heavy losses on the global bee industry and there are few effective control options. Among these methods to control mites, pesticides are extensively used as a cheap, easy to use, and high-efficiency control measure. However, bees are sensitive to many pesticides; thus, a balance between losses induced by drugs and maximum benefits are important for beekeeping and risk assessment. Read More

Environ Sci Pollut Res Int 2020 Feb 23;27(6):6505-6514. Epub 2019 Dec 23.

Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, F-25030, Besançon Cedex, France.

Fipronil (FPN), a phenylpyrazole insecticide, has been receiving increased attention owing to its toxicity, which is largely mediated through its effects on antioxidant systems. The present study was undertaken to assess the effects of resveratrol (RSV) and curcumin (CUR) on oxidative damage induced by FPN. Forty mature male Wistar rats were randomized into five groups (n = 8 per group): the first group was the control; the second was administered FPN (10 mg/kg); and the third, fourth, and fifth were co-treated with RSV (10 mg/kg), CUR (200 mg/kg), and their combination, respectively, 2 h prior to FPN administration. Read More