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Cell Mol Biol (Noisy-le-grand) 2018 Sep 30;64(12):11-14. Epub 2018 Sep 30.

Department of Elementary Education, Faculty of Education, Siirt University, Siirt, Turkey.

The worldwide increase in the rate of cancer incidence also leads to a significant increase in the use of chemotherapeutic agents. Unfortunately, the optimal clinical usefulness of these agents is heavy restricted by a high incidence of several organ toxicity and as well reason oxidative stress and bring about changing in antioxidant status. Kidney toxicity is a side effect often encountered with cyclophosphamide (CPM) which is commonly used in most cancer chemotherapy. Read More

Toxicol Lett 2018 Dec 4;299:124-128. Epub 2018 Oct 4.

Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, Campus Lagoas Marcosende, 36310 Vigo, Spain.

Paraoxon (POX) is an extremely neurotoxic organophosphorous compound (OP) which main toxic mechanism is the irreversible inhibition of cholinesterase. Although the cholinergic system has always been linked as responsible for its acute effects, experimental studies have suggested that the dopaminergic system also may be a potential target for OPs. Based on this, in this study, the acute intrastriatal effects of POX on dopaminergic neurotransmission were characterized in vivo using brain microdialysis in freely moving rats. Read More

Sci Total Environ 2019 Feb 25;650(Pt 2):2063-2073. Epub 2018 Sep 25.

Department of Zoology, Science College, King Saud University, Riyadh 11451, Saudi Arabia.

Fipronil (FPN), a commonly used phenylpyrazole pesticide can induce oxidative tissue damage following hazard usage. Due to the extensive household and commercial usage of FPN, its toxic effects on mammals received considerable attention. Finding the proper antioxidant that can overcome FPN-induced damage is essential. Read More

Toxicol Lett 2018 Dec 1;299:129-136. Epub 2018 Oct 1.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F 35000, Rennes, France. Electronic address:

Chlordecone is an organochlorine used in the 1970's as a pesticide in banana plantations. It has a long half-life in the soil and can potentially contaminate humans and animals through food. Chlordecone targets, and mainly accumulates in, the liver, leading to hepatomegaly and neurological signs in mammals. Read More

Chemosphere 2018 Dec 4;212:1085-1094. Epub 2018 Sep 4.

Institute of Environment and Ecology, Shandong Normal University, Ji'nan, 250014, People's Republic of China. Electronic address:

The electrocardiogram (ECG) has been widely used to objectively address the physical condition as an index of stress. Though a numerous accounts of investigations on aquatic organisms' ECGs have been made, differentiation of ECG parameters in responding to specific toxic chemicals has not been extensively studied. In this research, it is hypothesized that zebrafish (Danio rerio) ECG parameters would differently respond to different types of pollutants, a heavy metal, thallium (Tl, 0. Read More

Food Chem Toxicol 2018 Nov 22;121:573-582. Epub 2018 Sep 22.

UR 1264 MycSA, INRA, Centre INRA de Nouvelle Aquitaine - Bordeaux, 71 av Edouard Bourlaux, 33140, Villenave d'Ornon, France.

We analyzed a comprehensive set of contaminants in MON810 and NK603 genetically modified (GM) maize, and their non-GM counterparts, used in a rat feeding study (the GMO90 + project). Both the maize grains and the manufactured pellets were characterized. Only minor differences in contaminant levels between GM and corresponding non-GM harvests were evidenced. Read More

Environ Pollut 2018 Dec 14;243(Pt B):809-814. Epub 2018 Sep 14.

Department of Animal Biology, Federal University of Viçosa, Viçosa, MG 36570-000, Brazil. Electronic address:

Leaf-cutting ants are important pests of forests and agricultural crops in the Neotropical region. Atta sexdens colonies can be composed of thousands of individuals, which form a highly complex society with a single reproductive queen. Successful control of this species is achieved only if the queen is affected. Read More

Toxicol Lett 2018 Dec 18;299:47-55. Epub 2018 Sep 18.

Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, United States. Electronic address:

Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative toxicity in the rat N27 dopaminergic neuronal cells through increased oxidative stress and mitochondrial dysfunction. In this study, we investigated the involvement of NADPH oxidase (NOX) proteins in the combined treatment with dieldrin and lindane-induced dopaminergic neurotoxicity. Read More

Parasit Vectors 2018 Sep 20;11(1):515. Epub 2018 Sep 20.

Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Ratchadewee, Bangkok, 10400, Thailand.

Background: Mosquitoes transmit many vector-borne infectious diseases including malaria, dengue, chikungunya, yellow fever, filariasis, and Japanese encephalitis. The insecticidal δ-endotoxins Cry4, Cry11, and Cyt produced from Bacillus thuringiensis have been used for bio-control of mosquito larvae. Cry δ-endotoxins are synthesised as inactive protoxins in the form of crystalline inclusions in which they are processed to active toxins in larval midgut lumen. Read More

Nanoscale 2018 Oct;10(38):18205-18216

911 Hergot Avenue, Ruston, LA 71272, USA.

While most hair care formulations are developed on the basis of surfactants or polymers, we introduce self-assembly coating of micro and nanoparticles as the underlying principle for hair modification, protection and enhancement. Halloysite clay nanotubes formed by rolled sheets of aluminosilicate kaolin assemble on the surface of hair forming a robust multilayer coverage. Prior to the application, clay nanotubes were loaded with selected dyes or drug allowing for hair coloring or medical treatment. Read More

Chemosphere 2018 Nov 23;210:958-967. Epub 2018 Jul 23.

Laboratório de Ecofisiologia Animal, Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Paraná, Brazil.

The λ-cyhalothrin (CL) is a globally used pyrethroid insecticide that has been detected in different water bodies worldwide. However, studies on the effects of CL on freshwater fishes are still incipient. In this context, we evaluated the acute effects of a commercial formulation containing CL (Karate Zeon CS 50) in juveniles of the teleost Prochilodus lineatus exposed for 96 h to four concentrations of the active ingredient (5, 50, 250 and 500 ng. Read More

Chem Commun (Camb) 2018 Sep;54(76):10754-10757

School of Chemical Engineering and Technology, Hebei University of Technology, 8 Guangrong Road, Hongqiao District, Tianjin, 300130, P. R. China.

An integrated nanocatalyst (INC), denoted OPH@MIL-100(Fe), was synthesized by immobilizing a biocatalyst onto a metal-organic framework (MOF)-based catalyst, which can cascadingly degrade organophosphate nerve agents to 4-aminophenol (4-AP) and result in a sharp decrease of their toxicity up to 208-fold. Read More

Biomed Res Int 2018 8;2018:3895834. Epub 2018 Aug 8.

Laboratory of Biopesticides, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia.

The increasing insect resistance against delta-endotoxins is a serious problem which makes it urgent to look for new eco-friendly strategies. Combining these toxins with other biomolecules is one of the promising strategies against insect pests. In this work, we evaluated the bioinsecticidal potential of extracts and strain BLB250 against (Lepidoptera: Noctuidae) larvae. Read More

Chemosphere 2018 Dec 27;212:629-637. Epub 2018 Aug 27.

Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brazil. Electronic address:

Insecticides used in the agriculture and forestry have side effects on non-target organisms used as natural enemies. This study evaluated the histopathology and cytotoxicity of permethrin on the midgut of the non-target predatory bug, Podisus nigrispinus (Heteroptera: Pentatomidae) used in the biological control of pest insects. The toxicity and survival of this insect were determined using six concentrations of permethrin via ingestion. Read More

Ecotoxicol Environ Saf 2018 Nov 28;164:665-674. Epub 2018 Aug 28.

Key Laboratory of Pesticide Toxicology and Application Technique, College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 271018, China; Research Center of Pesticide Environmental Toxicology, Shandong Agricultural University, Tai'an, Shandong 271018, China. Electronic address:

Harmonia axyridis is an important biological control predator in greenhouses and agricultural fields, and it plays a significant role in the integrated pest management (IPM) of several arthropod pests. We studied the effects of eight insect growth-regulator insecticides (IGRs) on immature stages of H. axyridis by residual toxicity (eggs and pupae) and contact toxicity (larvae) to evaluate the risk of using these IGRs in IPM systems. Read More

Toxicol Lett 2018 Nov 25;297:34-41. Epub 2018 Aug 25.

Medical college, Hangzhou Normal University, No. 16 Xuelin Road, Xiasha Higher Education Park, Hangzhou 310036, Zhejiang, PR China. Electronic address:

The hypothesis of fetal origins unraveled that environmental exposures in early life could alter epigenetic modifications in the male germ-line, increasing the susceptibility to adult-onset diseases for generations. In our previous study, p,p'-dichlorodiphenoxydichloroethylene (p,p'-DDE), a representative endocrine disruptor, was found to induce transgenerational impaired male fertility with sperm Igf2 hypomethylation. However, whether other imprinted genes involved remains uncovered. Read More

Ecotoxicol Environ Saf 2018 Nov 24;164:548-553. Epub 2018 Aug 24.

Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados, Avenida Dourados-Itahum, km 12, Dourados 79804-970, Mato Grosso do Sul, Brazil; Postgraduate Program in Entomology and Biodiversity Conservation, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.

Throughout evolutionary history bees have developed complex communication systems. For social bees, communication is important for both the individual and the development of the colony. Successful communication helps bees to recognize relatives, defend the colony, and promote recruitment to optimize foraging of floral resources. Read More

Environ Pollut 2018 Nov 18;242(Pt B):1527-1534. Epub 2018 Aug 18.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

The levels and spatial distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in freshwater products from Northeast China were investigated by gas chromatography coupled to isotope dilution high-resolution mass spectrometry. All samples were on-spot sampled from main production regions of freshwater products in Northeast China, and these samples were used to systematically assess the potential health risks of OCPs and PCBs associated with consumption of these fishery products. Dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexane (HCHs), hexachlorobenzene (HCB) and PCBs were the major pollutants with 100% detection rates, and their levels ranged from 0. Read More

Se Pu 2018 Jun;36(6):523-530

Technical Center of Inspection and Quarantine, Shandong Entry-Exit Inspection and Quarantine Bureau, Qingdao 266002, China.

A method was developed for the determination of biomarkers related to toxicity of deltamethrin in rabbit urine by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The target analytes in this method are as follows:deltamethrin and its two metabolites (1-)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid (dibromochrysanthemic acid) and 3-phenoxybenzoic acid (3-PBA), and five toxic biomarkers, viz. serotonin hydrochloride (5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA), 3-nitropropionic acid (3-NPA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 6-methoxyguanine. Read More

Toxicol Lett 2018 Oct 16;296:132-138. Epub 2018 Aug 16.

Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Institute of Research in Public Health of the University of Montreal (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, H3C 3J7, Canada. Electronic address:

A controlled kinetic study was conducted in volunteers dermally exposed to the widely used lambda-cyhalothrin pyrethroid pesticide to document the time courses of relevant biomarkers of exposure, in order to better assess biomonitoring data in workers. Matador EC120 formulation (120 g/l) was applied on 40 cm of the forearm at a 0.25 mg/kg dose of lambda-cyhalothrin and left without occlusion or washing for 6 h. Read More

Ecotoxicol Environ Saf 2018 Nov 11;164:149-154. Epub 2018 Aug 11.

School of Agriculture and Food Science, Zhejiang A& F University, Lin'an, HangZhou 311300, China. Electronic address:

As a new tetronic acid derivative insecticide, spirotetramat has been reported to be toxic to an array of aquatic organisms. However, the toxic effects of spirotetramat on zebrafish especially at ovary are still obscure. Hereby, the acute toxicity of spirotetramat towards zebrafish（Danio rerio），as well as the changes on biochemical and histological traits of ovary were investigated. Read More

Environ Pollut 2018 Nov 26;242(Pt B):2078-2087. Epub 2018 Jun 26.

Center for Fisheries, Aquaculture and Aquatic Sciences and Department of Zoology, Southern Illinois University, Carbondale, IL 62901, United States. Electronic address:

The ecotoxicological effects of hydrophobic organic compound (HOC) contamination in sediment are often assessed using laboratory exposures of cultured invertebrates to field-collected sediment. The use of a sediment holding time (storage at 4 °C) between field sampling and the beginning of the bioassay is common practice, yet the effect of holding time on the reliability of bioassay results is largely unknown, especially for current-use HOCs, such as pyrethroid insecticides. Single-point Tenax extraction can be used to estimate HOC concentrations in the rapidly desorbing phase of the organic carbon fraction of sediment (i. Read More

Ecotoxicol Environ Saf 2018 Nov 1;163:594-603. Epub 2018 Aug 1.

School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300, China. Electronic address:

Plant allelochemicals are considered as the source of effective, economic and friendly-environmental algaecides. To uncover the anti-algal activities of Cinnamomum camphora fresh leaves and their main algicidal agents, we investigated the inhibitory effects of water and methanol extracts from C. camphora fresh leaves on Microcystis aeruginosa and Chlamydomonas reinhardtii cell growth, analyzed the composition of the water and methanol extracts, and determined the main compounds in extracts on the growth of the two algae and their anti-algal mechanism from photosynthetic abilities. Read More

Environ Pollut 2018 Nov 28;242(Pt B):1684-1692. Epub 2018 Jul 28.

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Residues of pyrethroid insecticides tend to accumulate in bed sediments due to their strong hydrophobicity. Rather than the total or bulk sediment concentration, it is the freely dissolved concentration (C) that drives toxicity to benthic invertebrates. In this study we developed thin film-based samplers for in situ ambient monitoring of pyrethroids at trace levels in sediment. Read More

Curr Microbiol 2018 Nov 31;75(11):1468-1476. Epub 2018 Jul 31.

College of Plant Science and Technology, Beijing Key Laboratory of New Technology in Agricultural Application, Beijing University of Agriculture, No. 7 Beinong Road, Changping District, Beijing, 102206, China.

Deltamethrin is a pyrethroid insecticide with high insecticidal activity and a wide range of applications. However, with the increased amount and scope of its application, the accumulated toxicity of deltamethrin has gradually raised concerns. In this study, a bacterium strain, which used deltamethrin as its sole carbon source and was named ZJ6 (Lysinibacillus sp. Read More

Parasit Vectors 2018 Jul 31;11(1):437. Epub 2018 Jul 31.

Department of Veterinary Sciences, University of Parma, 43126, Parma, Italy.

Background: Over-expression of ATP-binding cassette (ABC) transporter proteins has been implicated in resistance of ticks to acaricides. Tick cell lines are useful for investigating resistance mechanisms, as development of an in vitro model for the study of acaricide resistance would contribute to improving knowledge of the molecular basis behind drug processing and exclusion in ticks. In the present study, cultures of the Ixodes ricinus-derived cell line IRE/CTVM19 were treated with the acaricides amitraz, permethrin or fipronil to determine modulation of ABC transporter gene expression. Read More

Ecotoxicol Environ Saf 2018 Nov 27;163:349-355. Epub 2018 Jul 27.

Key Laboratory of Pesticide Toxicology & Application Technique, Shandong Agricultural University, Tai'an, Shandong 271018, PR China; College of Plant Protection, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. Electronic address:

The conventional emulsifiable concentrate (EC) formulation contains a large amount of aromatic solvents, which causes adverse effects to both the environment and human health due to the toxicity of the solvents. Here, we developed a 2.5% lambda-cyhalothrin EC formulation with ethylene glycol diacetate (EGDA) as the solvent, and the developed formulation serves as an environmental-friendly alternative to overcome the adverse effects of aromatic solvents. Read More

Aquat Toxicol 2018 Sep 19;202:181-187. Epub 2018 Jul 19.

Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

Chlordecone and fipronil are used as an insecticide and have been widely detected in the aquatic environments. However, their toxicity is still poorly investigated in aquatic invertebrates. In this study, we examined effects of chlordecone and fipronil on population growth and transcriptional regulation of the entire cytochrome P450 (CYP) genes in the freshwater rotifer Brachionus calyciflorus and the marine rotifer B. Read More

Int J Mol Sci 2018 Jul 20;19(7). Epub 2018 Jul 20.

Department of Biochemical Sciences, A. Rossi Fanelli, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy.

Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption. Among OCPs, particular attention was focused on the effects of β-hexaclorocyclohexane (β-HCH), a widely common pollutant. A detailed epidemiological study carried out on exposed population in the "Valle del Sacco" found correlations between the incidence of a wide range of diseases and the occurrence of β-HCH contamination. Read More

J Chem Ecol 2018 Nov 23;44(11):1022-1029. Epub 2018 Jul 23.

Core Facility Management Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-806, Republic of Korea.

Because juvenile hormone (JH) controls insect development and its analogs are used as insecticides, juvenile hormone disruptors (JHDs) represent potential sources from which novel pesticides can be developed. Many plant species harbor JHD activity, which has previously been attributed plant secondary metabolites (i.e. Read More

Ecotoxicol Environ Saf 2018 Nov 19;163:28-36. Epub 2018 Jul 19.

Programa de Pós-Graduação em Agricultura e Biodiversidade, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil; Departamento de Engenharia Agronômica, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil. Electronic address:

The recent decline of Apis mellifera populations around the world has been subject of intense research due to ecological and economic damages resulting from the loss of pollination services. The intensive use of insecticides from the neonicotinoids group is among the possible causal factors of this decline, including also sub-lethal effects. However, the use of synthetic insecticides has been increased on a global scale in the recent decades. Read More

Environ Pollut 2018 Oct 18;241:1091-1097. Epub 2018 Jun 18.

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:

Natural pyrethrins, one kind of insects' neural toxin, have been used worldwide for the control of pests of crops, livestock, and human beings. However, their specific mechanisms of action are incompletely understood and hence further investigation is required. Here we used a series of experiments including colony formation, fluorescent staining, western blotting, enzyme activity detection, immunofluorescence analysis, and real-time quantitative PCR (QPCR) to investigate whether natural pyrethrins (0-40 μg/mL) are able to modulate autophagy process through AMPK/mTOR signaling pathway, in order to reveal their cytotoxic mechanisms. Read More

J Agric Food Chem 2018 Aug 27;66(31):8246-8252. Epub 2018 Jul 27.

State Key Laboratory of Chemical Engineering , East China University of Science and Technology , Shanghai 200237 , PR China.

Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of λ-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. Read More

J Biochem Mol Toxicol 2018 Sep 17;32(9):e22196. Epub 2018 Jul 17.

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.

Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition effects of 2,4-dichlorophenoxyacetic acid dimethylamine salt (2,4-D DMA), haloxyfop-P-methyl, glyphosate isopropylamine, dichlorvos, and λ-cyhalothrin on purified GST. Read More

Ecotoxicol Environ Saf 2018 Oct 14;162:499-504. Epub 2018 Jul 14.

State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

The standard Folsomia candida test (ISO 11267), in which only the survival and reproduction of the parental generation (F0) were determined, is insufficient to assess the toxicity of chemicals, like endocrine disrupting chemicals (EDCs), since the effects of EDCs could last for several generations and sometimes can be transgenerational. It's necessary to assess the effects on subsequent generations to address the long-term consequences of these chemicals exposure. In this study, the effects of pentachlorophenol (PCP) and 2,2',4,4'-tetrabromodiphenyl (BDE47) were assessed on F0 and the first filial generation (F1) of F. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2018 Oct 18;212:47-55. Epub 2018 Jul 18.

Laboratorio de Ecotoxicología Acuática, INIBIOMA- CONICET- CEAN, Ruta provincial 61, km 3, 8371 Junín de los Andes, Neuquén, Argentina. Electronic address:

Fish can be simultaneously or sequentially exposed to various kinds of pollutants, resulting in combined effects. Polycyclic aromatic hydrocarbons induce cytochrome P450 monooxygenase 1A (CYP1A) expression, which catalyzes the conversion of the organophosphorus insecticide chlorpyrifos (CPF) into its most active derivative, CPF-oxon. CPF-oxon inhibits CYP1A and other enzymes, including carboxylesterases (CEs) and acetylcholinesterase (AChE). Read More

Parasit Vectors 2018 Jul 13;11(1):417. Epub 2018 Jul 13.

Center of Insect Vector Study, Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Background: In a previous screening program for mosquitocides from local edible plants in Thailand, essential oils (EOs) of Cyperus rotundus, Alpinia galanga and Cinnamomum verum, were found to possess promising adulticidal activity against Aedes aegypti. With the aim of reducing usage of conventional insecticides and improving the management of resistant mosquito populations, this study was designed to determine the potential synergism in the adulticidal efficacy of EOs on permethrin toxicity against Ae. aegypti, both pyrethroid-resistant and -susceptible strains. Read More

Food Chem Toxicol 2018 Oct 6;120:89-97. Epub 2018 Jul 6.

Departamento de Bioquímica, Biología Molecular y Celular. Universidad de Zaragoza, Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain; Centro de Investigaciones Biomédicas En Red de Enfermedades Raras (CIBERER), Zaragoza, Spain; Fundación ARAID, Zaragoza, Spain. Electronic address:

Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. Read More

Environ Pollut 2018 Nov 27;242(Pt A):329-337. Epub 2018 Jun 27.

Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Electronic address:

Persistent organic pollutants (POPs) have the potential to impair the endocrine regulation of organisms and alter their ability to respond to environmental changes. We studied whether polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) affected the endocrine regulation of free-living and captive red kites (Milvus milvus) through studying the dynamics of corticosterone (CORT) and dehydroepiandrosterone (DHEA). We sampled migratory free-living kites coming from northern Europe and captive kites born in a rehabilitation center in Spain. Read More

Arh Hig Rada Toksikol 2018 Jun;69(2):86-102

Mutagenesis Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Humans have used insecticides since ancient times. The spectrum and potency of available insecticidal substances has greatly expanded since the industrial revolution, resulting in widespread use and unforeseen levels of synthetic chemicals in the environment. Concerns about the toxic effects of these new chemicals on non-target species became public soon after their appearance, which eventually led to the restrictions of use. Read More

Chemosphere 2018 Nov 5;210:129-138. Epub 2018 Jul 5.

School of Physics and Electronic Science, Shandong Normal University, Ji'nan 250014, Shandong, China.

As behavior shows a distinct circadian rhythm, it is hypothesized that circadian rhythms based on zebrafish (Danio rerio) behavior responses could be affected by contaminants in this study, and then the behavior strength of zebrafish exposed to 0.005 mg/L Cadmium chloride (CdCl), 0.01 mg/L Dibasic Sodium Phosphate (NaHPO), 0. Read More

Ecotoxicol Environ Saf 2018 Jan 10;147:1023-1034. Epub 2017 Oct 10.

Research & Development Center of Biorational Pesticide, Northwest A & F University, Yangling 712100, China; Research Center of Biopesticide Technology and Engineering, Yangling, Shaanxi Province 712100, China.

We attempted to elucidate the comparative effects between wilforgine and chlorantraniliprole on the microstructure/ultrastructure of muscle tissue in Mythimna separate larvae. The typical toxicity symptoms of M. separata larvae upon wilforgine treatment was feeding cessation and flaccid paralysis, whereas feeding cessation and contraction paralysis were the main poisoning symptoms wrought by chlorantraniliprole. Read More

Ecotoxicol Environ Saf 2018 Jan 9;147:1017-1022. Epub 2017 Oct 9.

Zoology Department, Faculty of Science, Cairo University, Egypt.

Freshwater snails are used as brilliant biomarkers of aquatic ecosystem pollution by chemical compounds. The objective of this study is to highlight the ecotoxicological impacts of the insecticide Match 5%EC (its active ingredient is lufenuron 5% EC) on Biomphalaria alexandrina snails the intermediate host of Schistosoma mansoni in Egypt. The present investigation recorded a remarkable molluscicidal effect of lufenuron 5% EC on these snails and there was a decrease in total number of their hemocytes after exposure. Read More

J Biochem Mol Toxicol 2018 Aug 5;32(8):e22174. Epub 2018 Jul 5.

Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra, 136 119, India.

Toxicological studies have demonstrated the relation between use of agrochemicals and fertility issues within males. Thus, the present study aimed to elucidate the propensity of cypermethrin (CYP) in bringing testicular germ cell apoptosis and effective attenuation by vitamins C and E in caprines. Reproductive toxicity of CYP was evaluated using histomorphological, cytological, and biochemical changes in the testicular germ cells in dose-dependent (1, 5, 10 μg/mL) and time-dependent (4, 6, 8 h) manner. Read More

Environ Monit Assess 2018 Jul 4;190(8):449. Epub 2018 Jul 4.

Pesticide Chemistry and Toxicology, The Islamic University, Gaza, Palestine.

Pesticide residues threaten fish that live in rivers. This study investigated the effects of Nemacur, malathion, and diuron on freshwater fish behavior, mortality, acetylcholinesterase (ACHE) activity, liver biomarkers, and residue accumulation. Fish were exposed to individual concentration of Nemacur, malathion, and diuron at 1 mg/L and to binary mixtures in glass aquarium 16 L capacity. Read More

J Immunotoxicol 2018 12;15(1):104-118

b Department of Biology , University of La Verne , La Verne , CA , USA.

Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pesticides, such as methoxychlor (MXC), have adverse effects on immune cells, but no studies have addressed the impact of HPTE, the primary metabolite of MXC. Read More

Comp Biochem Physiol C Toxicol Pharmacol 2018 Oct 30;212:25-33. Epub 2018 Jun 30.

Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Engineering Research Center of Agriculture, Shanghai Ocean University, 999 Huchenghuan Road, Lingang New District, Shanghai 201306, China. Electronic address:

The oxidative stress and genotoxic effect of deltamethrin on the Chinese mitten crab Eriocheir sinensis were assessed using several commonly used biomarkers in this study. The results showed that the 48 h and 96 h LC values of deltamethrin to E. sinensis were 2. Read More

Environ Toxicol 2018 Sep 2;33(9):962-971. Epub 2018 Jul 2.

Department of Basic Sciences, Mississippi State University College of Veterinary Medicine, Mississippi State, Mississippi.

Recent epidemiological studies have revealed significant positive associations between exposure to organochlorine (OC) pesticides and occurrence of the metabolic syndrome and there are a growing number of animal-based studies to support causality. However, the cellular mechanisms linking OC compound exposure and metabolic dysfunction remain elusive. Therefore, the present study was designed to determine if direct exposure to three highly implicated OC compounds promoted hepatic steatosis, the hepatic ramification of the metabolic syndrome. Read More

J Environ Sci (China) 2018 Jul 5;69:239-250. Epub 2017 Nov 5.

State Key Laboratory of Lake Science and Environment, Nanjing 210008, China.

The influence of tetracycline (TC) antibiotics on phosphine (PH) production in the anaerobic wastewater treatment was studied. A lab-scale anaerobic baffled reactor with three compartments was employed to simulate this process. The reactor was operated in a TC-absence wastewater and 250μg/L TC-presence wastewater for three months after a start-up period, respectively. Read More

Parasit Vectors 2018 Jun 25;11(1):361. Epub 2018 Jun 25.

Merck Animal Health, 2 Giralda Farms, Madison, NJ, 07940, USA.

Background: The poultry red mite Dermanyssus gallinae negatively impacts bird welfare and health, and interferes with egg production and quality, while emerging acaricide resistance limits control options. Fluralaner, a novel miticide for administration in drinking water, is approved for control of D. gallinae infestations. Read More