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Front Immunol 2022 3;13:916100. Epub 2022 Jun 3.

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.

Deltamethrin (Del) is a widely used pyrethroid insecticide and a dangerous material that has brought serious problems to the healthy breeding of aquatic animals. However, the toxicological mechanisms of Del on channel catfish remain unclear. In the present study, we exposed channel catfish to 0, 0. Read More

Molecules 2022 Jun 15;27(12). Epub 2022 Jun 15.

"Coriolan Dragulescu" Institute of Chemistry, 24 M. Viteazu Ave, 300223 Timisoara, Romania.

Vector-borne infectious diseases are responsible for the deaths of over 700,000 people annually, than 400,000 of them resulting from malaria. The mosquito is one of the dominant vector species of human malaria transmission. A significant issue of the conventional insecticides which target the arthropod borne infectious diseases is their induced resistance. Read More

Int J Mol Sci 2022 Jun 7;23(12). Epub 2022 Jun 7.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The increased concern regarding the reduction in female fertility and the impressive numbers of women undergoing fertility treatment support the existence of environmental factors beyond inappropriate programming of developing ovaries. Among these factors are pyrethroids, which are currently some of the most commonly used pesticides worldwide. The present study was performed to investigate the developmental effects of the pyrethroid-based insecticide allethrin on ovarian function in rat offspring in adulthood. Read More

J Hazard Mater 2022 Aug 3;436:129292. Epub 2022 Jun 3.

School of Environment and Guangdong Provincial Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 511443, China.

Pesticides from agricultural activities transfer to surrounding waterways, jeopardizing aquatic ecosystem. To better characterize transfer of pesticide residues and toxicity, a batch of pesticides were analyzed in 22 sediment samples collected from the ditches (< 5 m away from field) and receiving streams nearby a vegetable planting area, South China. Sum concentrations of pesticides in ditch sediments (152 ± 121 ng/g dry wt. Read More

Pestic Biochem Physiol 2022 Jun 25;184:105132. Epub 2022 May 25.

Department of Entomology, Kansas State University, Manhattan, KS 6506, USA. Electronic address:

Deltamethrin is one of the most effective pyrethroid compounds used in stored product protection to control a wide range of pests. However, the development of resistance to deltamethrin in many pest species has been reported and useful research to overcome this problem is required. The present study investigated the possible synergistic effect of a commercial formulation of a mixture of the short chain fatty acids, octanoic, nonanoic and decanoic acid, in a formulation called "C8910" on the lethal activity of deltamethrin against susceptible (Lab-S) and relatively pyrethroid-resistant (Pyr-R) strains of T. Read More

Pestic Biochem Physiol 2022 Jun 6;184:105115. Epub 2022 May 6.

Laboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium. Electronic address:

Essential oils (EOs) can provide important alternatives to chemical insecticides in the control of pests. In this study, 12 EOs of native plant species from Iran were evaluated for their adulticidal activity against the house fly. In addition, we examined the insecticidal activity of Zataria multiflora and Rosmarinus officinalis EOs on adult female house flies from pyrethroid and organophosphate resistant and susceptible populations, using both fumigant and topical bioassays. Read More

Pestic Biochem Physiol 2022 Jun 6;184:105114. Epub 2022 May 6.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China. Electronic address:

Previously, deltamethrin (a Type-II pyrethroid) has been reported to increase triglyceride (fat) accumulation in adipocytes, while its underlying molecular mechanism is not fully determined. The aim of this study was to further investigate the molecular mechanisms of deltamethrin induced fat accumulation in murine 3T3-L1 adipocytes. Consistent to previous reports, deltamethrin (10 μM) significantly promoted adipogenesis in 3T3-L1 adipocytes. Read More

Pestic Biochem Physiol 2022 Jun 20;184:105104. Epub 2022 Apr 20.

College of Plant Science, Jilin University, Changchun 130062, PR China. Electronic address:

Cyantraniliprole, a second-generation anthranilic diamide insecticide, is widely used to control chewing and sucking pests. ATP-binding cassette transporters (ABCs) are a ubiquitous family of membrane proteins that play important roles in insect detoxification mechanisms. However, the potential effects of ABCs on cyantraniliprole-resistance remain unclear. Read More

Pestic Biochem Physiol 2022 Jun 24;184:105059. Epub 2022 Feb 24.

Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:

Hibernation is a short-term survival strategy for ectotherms to cope with cold weather and food shortages. The energy sources stored before hibernation are used not only in the winter, but also in preparation for reproduction. Reproductive physiology and behavior are primarily regulated by the hypothalamus-pituitary-gonad (HPG) axis. Read More

Sci Rep 2022 Jun 16;12(1):10108. Epub 2022 Jun 16.

Postdoctoral Mobile Station of Crop Science, Henan Agricultural University, Wenhua Road, Jinshui District, Zhengzhou, Henan, China.

Glutathione S-transferase (GSTs) are members of multifunction enzymes in organisms and mostly known for their roles in insecticide resistance by conjugation. Spodoptera litura (Fabricius) is a voracious agricultural pest widely distributed in the world with high resistance to various insecticides. The function of GSTs in the delta group of S. Read More

Sci Rep 2022 Jun 9;12(1):9498. Epub 2022 Jun 9.

The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, 75270, Pakistan.

Different pesticide chemicals are used to enhance crop yield by protecting from pests. Organophosphate (OPs) and Pyrethroid (PYR) are used in fields of Sanghar, Sindh Pakistan. PON1 an antioxidant enzyme implicated in OPs detoxification may predispose by OPs chronic exposure. Read More

Sci Total Environ 2022 Sep 4;838(Pt 3):156347. Epub 2022 Jun 4.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Beijing Key Laboratory of Industrial Wastewater Treatment and Reuse, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Fenvalerate is a broadly used type II pyrethroid with a potential toxic effect in fish. However, information on the immunotoxicity of fenvalerate in fish is scarce. Here, to discover the immunotoxicity of fenvalerate and its underlying mechanism in fish, adult Chinese rare minnow was exposed to fenvalerate at 0, 0. Read More

Chem Biol Interact 2022 Aug 30;362:110002. Epub 2022 May 30.

Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

Empagliflozin, a selective sodium-glucose co-transporter-2 inhibitor, has been demonstrated to provide additional non-glycemic benefits, including neuroprotection. Endoplasmic reticulum (ER) stress is a key player in neurodegeneration and occurs at the crossroads of other pathologic mechanisms; however, its role in the pathogenesis of Parkinson's disease (PD) is still elusive. miR-211-5p regulates neuronal differentiation and viability and was predicted to target CHOP, a downstream effector in the ER stress pathway. Read More

Microb Cell Fact 2022 May 28;21(1):97. Epub 2022 May 28.

Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education, Yunnan Normal University, Kunming, 650500, Yunnan, China.

Background: Carbamate pesticides have been widely used in agricultural and forestry pest control. The large-scale use of carbamates has caused severe toxicity in various systems because of their toxic environmental residues. Carbaryl is a representative carbamate pesticide and hydrolase/carboxylesterase is the initial and critical enzyme for its degradation. Read More

BMC Nephrol 2022 May 28;23(1):198. Epub 2022 May 28.

Military Medical Institute, Szaserów 128 Street, 04-141, Warszawa, Poland.

Background: Pyrethroids are used for insect control. They act on voltage-gated sodium channels in neurons. Lambdacyhalothrin (LCH) is a type II pyrethroid producing choreoatetosis and salivation in rodents. Read More

Int J Hyg Environ Health 2022 Jun 28;243:113988. Epub 2022 May 28.

BK21 FOUR R & E Center for Learning Health System, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South Korea; Department of Health and Environmental Science, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:

Pyrethroid insecticides have been broadly used as pest control in agriculture and residential spaces, exerting high effectiveness of insecticidal property and relatively low toxicity to humans. Several animal studies suggested that exposure to pyrethroids may induce hematological abnormalities, thereby altering the number of blood cells and resulting in blood disorders. However, no epidemiologic study has reported on the effect of pyrethroid insecticide exposure on hematological changes, except for occupational exposure. Read More

Aquat Toxicol 2022 Jul 18;248:106194. Epub 2022 May 18.

Beijing Advanced Innovation Centre for Food Nutrition and Human Health, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, PR China.

Pesticides are widely used and frequently detected in the environment. The evaluation on the toxic effects of the co-exposure of two or more pesticides or related metabolites could reflect the real situation of the exposing risks. In this study, zebrafish was used as a model to investigate the potential toxic interactions of chlorpyrifos and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on the survival rate, oxidative stress response and neurotoxicity, as well as their bioaccumulation and distribution in tissues. Read More

Toxins (Basel) 2022 05 4;14(5). Epub 2022 May 4.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

were evaluated in order to investigate the insecticidal activity towards adults. The LC values were promising and reflected the bio-efficacy of the tested extracts (39 and 42 mg/L), respectively, and reduced the fecundity markedly. Using GC/MS analysis, the major components were n-hexadecanoic, linolenic, hexadecenoic, myristic, stearic acids, linolelaidic acid, methyl ester and some terpenoids, alkaloids, and hydrocarbons. Read More

Toxicol Ind Health 2022 Jul 24;38(7):399-407. Epub 2022 May 24.

Key Lab of Environment and Health, Key Laboratory of Human Genetics and Environmental Medicine, School of Public Health, 38044Xuzhou Medical University, Xuzhou, China.

Cypermethrin, an extensively used pyrethroid pesticide, is regarded as one of many endocrine-disrupting chemicals (EDCs) with anti-androgenic activity to damage male reproductive systems. We previously found cypermethrin-induced apoptosis in mouse Sertoli cells TM4. We hypothesized cypermethrin-induced TM4 apoptosis by the endoplasmic reticulum (ER) pathway. Read More

Environ Res 2022 Sep 21;212(Pt D):113496. Epub 2022 May 21.

School of Biotechnology, KIIT University, Bhubaneswar, 751024, India; School of Law, KIIT University, Bhubaneswar, 751024, India. Electronic address:

Hexachlorocyclohexane (HCH) has been recognized as an effective insecticide to protect crops against grasshoppers, cohort insects, rice insects, wireworms, and other agricultural pests and; for the control of vector-borne diseases such as malaria. It is a cyclic, saturated hydrocarbon, which primarily exists as five different stable isomers in the environment. Though the use of HCH is banned in most countries owing to its adverse effects on the environment, its metabolites still exist in soil and groundwater, because of its indiscriminate applications. Read More

Chem Res Toxicol 2022 Jun 24;35(6):1045-1058. Epub 2022 May 24.

Département des sciences biologiques, Groupe TOXEN, Université du Québec à Montréal, C.P. 8888, Succursale Centre-Ville, Montréal, Quebec H3C 3P8, Canada.

The population of yellow perch () in lake Saint-Pierre (QC, Canada) has been dramatically declining since 1995 without any sign of recovery. Previous studies have shown disrupted retinoid (vitamin A) metabolic pathways in these fish, possibly due to the influence of pesticides. Our study aimed to evaluate the impact of some herbicides and neonicotinoids on retinoic acid catabolism in the fish hepatic cell lines PLHC-1 and ZFL. Read More

Sci Total Environ 2022 Sep 20;838(Pt 2):156027. Epub 2022 May 20.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Exposure to pyrethroids, a significant class of the most widely used agricultural chemicals, has been associated with an increased risk of Parkinson's disease (PD). However, although many different pyrethroids induce roughly the same symptoms of Parkinsonism, the underlying mechanisms remain unknown. To find the shared key features among these mechanisms, we focused on 3-phenoxybenzoic acid (3-PBA), a common and prominent metabolite of most pyrethroids produced via hydrolysis by CEs in mammals. Read More

Environ Pollut 2022 Aug 19;307:119414. Epub 2022 May 19.

Department of General Microbiology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Red Sea Research Center (RSRC), Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. Electronic address:

Micropollutants (MPs) include a wide range of biological disruptors that can be toxic to wildlife and humans at very low concentrations (<1 μg/L). These mainly anthropogenic pollutants have been widely detected in different areas of the planet, including the deep sea, and have impacts on marine life. Because of this potential toxicity, the global distribution, quantity, incidence, and potential impacts of deep-sea MPs were investigated in a systematic review of the literature. Read More

Sci Total Environ 2022 Sep 19;838(Pt 3):155666. Epub 2022 May 19.

U.S. Environmental Protection Agency, ORD/CCTE, Research Triangle Park, NC 27709, USA. Electronic address:

One of the biggest challenges in ecological risk assessment is determining the impact of multiple stressors on individual organisms and populations in real world scenarios. Frequently, data derived from laboratory studies of single stressors are used to estimate risk parameters and do not adequately address scenarios where other stressors exist. Emerging 'omic technologies, notably metabolomics, provide an opportunity to address the uncertainties surrounding ecological risk assessment of multiple stressors. Read More

Colloids Surf B Biointerfaces 2022 Aug 13;216:112565. Epub 2022 May 13.

Department of Chemistry, College of Science, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:

Pyrethroid insecticides are a group of widely used bio-mimetic synthetic pesticides. However, recent studies reported that they could have an accumulation effect in human which may cause series of health problems. Estrogen receptors (ER) are a class of nuclear receptors that are vital in proper physiological behavior of estrogens. Read More

Environ Pollut 2022 Aug 16;306:119473. Epub 2022 May 16.

IMDEA Water Institute, Science and Technology Campus of the University of Alcalá, Avda. Punto Com 2, 28805, Alcalá de Henares, Madrid, Spain.

Microplastics (MPs) have been shown to act as sorbent phases and thus carriers of organic chemicals in the aquatic environment. Therefore, concerns exist that MP ingestion increases the uptake and accumulation of organic chemicals by aquatic organisms. However, it is unclear if this pathway is relevant compared to other exposure pathways. Read More

Pharmacol Res Perspect 2022 06;10(3):e00954

Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Advanced hepatocellular carcinoma (HCC) results in generally poor clinical outcomes and necessitates better therapeutic strategies. Ivermectin, which is an existing anti-parasitic drug, has been recently identified as a novel anti-cancer drug. In line with previous efforts, this work demonstrates the translational potential of ivermectin to treat advanced HCC. Read More

Int J Environ Res Public Health 2022 05 5;19(9). Epub 2022 May 5.

Department of Chemical Safety, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland.

Endometriosis is a disease characterized by the presence of the uterine endometrium outside of its normal location. As the etiology of endometriosis is not well known and hormonal imbalance is central to disease pathogenesis, the potential contribution of exposure to endocrine-disrupting chemicals (EDCs) has been hypothesized in endometriosis. A systematic search of the literature was carried out to identify relevant studies using: PubMed, Scopus, Elsevier, Springer; EBSCO, and Web of Science. Read More

Environ Res 2022 Sep 10;212(Pt C):113461. Epub 2022 May 10.

Center for Environmental Research and Community Health, School of Public Health, University of California, Berkeley, CA, 94720, USA. Electronic address:

Background: Epidemiological studies suggest that exposure to p,p'-dichloro-diphenyl-trichloroethane (p,p'-DDT) is associated with poorer cognitive function in children and adolescents, but the neural mechanisms underlying this association remain unclear.

Objective: We investigated associations of prenatal and childhood exposure to p,p'-DDT and its metabolite p,p'-dichloro-diphenyl-dichloroethylene (p,p'-DDE) with cortical activation in adolescents using functional near-infrared spectroscopy (fNIRS).

Methods: We administered fNIRS to 95 adolescents from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) aged 15-17 years. Read More

Mol Med Rep 2022 06 11;25(6). Epub 2022 May 11.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, P.R. China.

The aim of the present study was to examine the neuroprotective effects of a panel of active components of ginseng and to explore their molecular mechanisms of action in two rotenone (Rot)‑induced models of Parkinson's disease: An model using the human neuroblastoma cell line SH‑SY5Y and an model using . Ginsenoside Re (Re) was identified as the most potent inhibitor of Rot‑induced cytotoxicity in SH‑SY5Y cells by Cell Counting kit‑8 assay and lactate dehydrogenase release assay. Flow cytometry, Hoechst staining, Rhodamine 123 staining, ATP and cytochrome c release revealed that Re rescue of Rot‑induced mitochondrial dysfunction and inhibition of the mitochondrial apoptotic pathway. Read More