2,358 results match your criteria Toxicity Hallucinogen


E-cigarette, or Vaping, Product Use-Associated Lung Injury Among Clusters of Patients Reporting Shared Product Use - Wisconsin, 2019.

MMWR Morb Mortal Wkly Rep 2020 Mar 6;69(9):236-240. Epub 2020 Mar 6.

On July 10, 2019, Wisconsin Department of Health Services (WDHS) was notified of five previously healthy adolescents with severe lung injuries who reported use of e-cigarette, or vaping, products before symptom onset. As of December 31, 2019, 105 confirmed or probable cases of e-cigarette, or vaping, product use-associated lung injury (EVALI)* had been reported to WDHS . Three social clusters (A, B, and C), comprising eight EVALI patients (cluster A = two patients, cluster B = three, and cluster C = three) were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6909a4DOI Listing

Self-reported negative outcomes of psilocybin users: A quantitative textual analysis.

PLoS One 2020 21;15(2):e0229067. Epub 2020 Feb 21.

Department of Psychology, Pontifícia Universidade Católica, São Paulo, Brazil.

Psilocybin, a substance mainly found in mushrooms of the genus psilocybe, has been historically used for ritualistic, recreational and, more recently, medicinal purposes. The scientific literature suggests low toxicity, low risk of addiction, overdose, or other causes of injury commonly caused by substances of abuse, with growing interest in the use of this substance for conditions such as treatment-resistant depression. However, the presence of negative outcomes linked to psilocybin use is not clear yet. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229067PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034876PMC

Lysergic acid diethylamide causes mouse retinal damage by up-regulating p-JAK1/p-STAT1.

Cutan Ocul Toxicol 2020 Jun 9;39(2):106-110. Epub 2020 Mar 9.

Department of Ophthalmology, 958 Army Hospital, ChongQin, People's Republic of China.

Lysergic acid diethylamide (LSD) is a powerful hallucinogen with high potential for abuse. There is far less known about its effects on the retina, especially the underlying mechanisms. This study was to investigate the acute toxicity of LSD on the retina of C57 mice and its mechanisms of action. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2020.1730883DOI Listing

Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, August 2019-January 2020.

MMWR Morb Mortal Wkly Rep 2020 Jan 24;69(3):90-94. Epub 2020 Jan 24.

Since August 2019, CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical stakeholders have been investigating a nationwide outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) (1). This report updates patient demographic characteristics, self-reported substance use, and hospitalization dates for EVALI patients reported to CDC by states, as well as the distribution of emergency department (ED) visits related to e-cigarette, or vaping, products analyzed through the National Syndromic Surveillance Program (NSSP). As of January 14, 2020, a total of 2,668 hospitalized EVALI cases had been reported to CDC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6903e2DOI Listing
January 2020

Intoxication with 3-MeO-PCP alone: A case report and literature review.

Medicine (Baltimore) 2019 Dec;98(52):e18295

CHU Rennes, Department of Forensic Toxicology.

Rationale: 3-Methoxyphencyclidine (3-MeO-PCP) is a new psychoactive substance derived from phencyclidine. Although it can lead to severe intoxications, the main manifestations and optimal management have not been well characterized. Here, we report 2 cases of 3-MeO-PCP intoxication in the same patient, and summarize the manifestations of this intoxication reported in literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000018295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946333PMC
December 2019

Patient Characteristics and Product Use Behaviors Among Persons with E-cigarette, or Vaping, Product Use-Associated Lung Injury - Indiana, June ̶ October 2019.

MMWR Morb Mortal Wkly Rep 2019 Dec 13;68(49):1139-1141. Epub 2019 Dec 13.

As of December 4, 2019, a total of 2,291 cases of hospitalized e-cigarette, or vaping, product use-associated lung injury (EVALI) have been reported from 50 states, the District of Columbia, and two U.S. territories (Puerto Rico and the U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6849a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919291PMC
December 2019

[Neurotrophic mechanisms of psychedelic therapy].

Biol Aujourdhui 2019 12;213(3-4):121-129. Epub 2019 Dec 12.

CNRS ERL 3649 « Neuroplasticité et thérapies des addictions », UMR-S 1124, Université Paris Descartes, 4, avenue de l'Observatoire, 75006 Paris, France.

Psychedelic drugs, often referred to as hallucinogens, are quite distinct from other classes of psychotropic drugs. Although the subjective and behavioral effects they induce are quite dramatic, they possess little addictive potential when compared to nicotine, alcohol or opiates. Since the discovery of ketamine antidepressant effects, there has been growing interest for these molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019015DOI Listing
May 2020
5 Reads

Designer drugs – still a threat?

Przegl Epidemiol 2019 ;73(3):337-347

Medical University of Bialystok, Department of Psychiatry

Introduction: In Poland, an increasing number of psychoactive substances are becoming prohibited by law as psychotropic or narcotic substances, or as new psychoactive substances (NPSs). Owing to the enormous technological possibilities offered by today’s science, synthesis of new derivatives of prohibited compounds is no longer a problem. The moment a dangerous substance is outlawed, new designer drugs (in Poland known as ‘dopalacze’) appear on the market. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.32394/pe.73.23DOI Listing

Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.

Toxicol Lett 2020 Feb 12;319:129-137. Epub 2019 Nov 12.

UCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no 228, Porto, Portugal. Electronic address:

The increasing use of synthetic cannabinoids (SCBs) in recreational settings is becoming a new paradigm of drug abuse. Although SCBs effects mimic those of the Cannabis sativa plant, these drugs are frequently more potent and hazardous. It is known that endocannabinoid signalling plays a crucial role in diverse reproductive events such as placental development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.11.004DOI Listing
February 2020
4 Reads

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.

Neural Regen Res 2020 May;15(5):802-816

Department of Biomedical Sciences; National Institute of Neuroscience (INN), University of Cagliari, Cagliari, Italy.

Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the rise among young and adult people. The present review summarizes recent findings on the peripheral and central toxicity elicited by "old" and "new" synthetic psychoactive substances in humans and experimental animals, focusing on amphetamine derivatives, hallucinogen and dissociative drugs and synthetic cannabinoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.268895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990793PMC

Cytologic features of vaping-induced lung injury: A case report.

Diagn Cytopathol 2020 Feb 12;48(2):174-176. Epub 2019 Nov 12.

Department of Pathology, Rush University Medical Center, Chicago, Illinois.

Vaping-induced lung injury is a recently recognized phenomenon owing to the rising popularity of e-cigarette use. A cluster of cases of varying severity, including six deaths, was recently reported in the United States by the Centers for Disease Control. The objective of this report is to highlight the cytologic features suggestive of vaping-induced lung injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dc.24343DOI Listing
February 2020

Cardiotoxic effects of [3-[2-(diethylamino)ethyl]-1H-indol-4-yl] acetate and 3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-ol.

Toxicol Lett 2020 Feb 6;319:40-48. Epub 2019 Nov 6.

National Institute of Drug and Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju, Republic of Korea. Electronic address:

Two synthetic tryptamines, namely [3-[2-(diethylamino)ethyl]-1H-indol-4-yl] acetate (4-AcO-DET) and 3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-ol (4-HO-MET), are abused by individuals seeking recreational hallucinogens. These new psychoactive substances (NPSs) can cause serious health problems because their adverse effects are mostly unknown. In the present study, we evaluated the cardiotoxicity of 4-AcO-DET and 4-HO-MET using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, electrocardiography (ECG), and the human ether-a-go-go-related gene (hERG) assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.10.022DOI Listing
February 2020

Focus on Adolescent Use of Club Drugs and "Other" Substances.

Pediatr Clin North Am 2019 12;66(6):1121-1134

Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Suite 2A, Detroit, MI 48201, USA.

Club drugs and "other" abusable substances are briefly overviewed as a reminder about the wide variety of known and unknown substances used by adolescents, the high potential for direct and interactive substance use effects to manifest acutely and chronically, and the vigilance needed to anticipate and recognize the new effects and drug-drug interactions arising as novel substances continue to be custom "designed," manufactured, and marketed to meet substance use trends. This article discusses dextromethorphan, flunitrazepam (Rohypnol), gamma-hydroxybutyrate, inhalants, ketamine, lysergic acid diethylamide, methylenedioxymethamphetamine, phencyclidine, Salvia divinorum (salvia), synthetic cannabinoids, and synthetic cathinones (bath salts). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pcl.2019.08.013DOI Listing
December 2019

Update: Characteristics of Patients in a National Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injuries - United States, October 2019.

MMWR Morb Mortal Wkly Rep 2019 Nov 1;68(43):985-989. Epub 2019 Nov 1.

CDC, the Food and Drug Administration, state and local health departments, and other public health and clinical stakeholders are investigating a national outbreak of electronic-cigarette (e-cigarette), or vaping, product use-associated lung injury (EVALI) (1). As of October 22, 2019, 49 states, the District of Columbia (DC), and the U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6843e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822806PMC
November 2019
5 Reads

Repeated Vaginal Exposures to the Common Cosmetic and Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain in ND4 Mice.

Int J Mol Sci 2019 Oct 28;20(21). Epub 2019 Oct 28.

Biology Department, Macalester College, Saint Paul, MN 55105, USA.

A history of allergies doubles the risk of vulvodynia-a chronic pain condition of unknown etiology often accompanied by increases in numbers of vulvar mast cells. We previously established the biological plausibility of this relationship in mouse models where repeated exposures to the allergens oxazolone or dinitrofluorobenzene on the labiar skin or inside the vaginal canal of ND4 Swiss Webster outbred mice led to persistent tactile sensitivity and local increases in mast cells. In these models, depletion of mast cells alleviated pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20215361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862067PMC
October 2019

A latent class analysis of drug and substance use patterns among patients treated in emergency departments for suspected drug overdose.

Addict Behav 2020 02 15;101:106142. Epub 2019 Oct 15.

Division of Overdose Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, USA.

Introduction: Polysubstance use and misuse can increase risks for nonfatal and fatal drug overdose. To categorize drugs used in combination in nonfatal overdoses, we analyzed data from emergency department (ED) overdose-related visits in 18 states funded by CDC's Enhanced State Opioid Overdose Surveillance (ESOOS) program.

Methods: From 2017 to 2018, 120,706 ED visits included at least one hospital discharge code indicating acute drug poisoning for opioids, stimulants, hallucinogens, cannabis, anti-depressants, sedatives, alcohol, benzodiazepines, or other psychotropic drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addbeh.2019.106142DOI Listing
February 2020

5-HT receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model.

Life Sci 2019 Nov 15;236:116790. Epub 2019 Oct 15.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA. Electronic address:

Aims: Although the bulk of research into the biology of serotonin 5-HT receptors has focused on its role in the CNS, selective activation of these receptors in peripheral tissues can produce profound anti-inflammatory effects. We previously demonstrated that the small molecule 5-HT receptor agonist (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI] inhibits TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT receptor activation and prevents the development of, and inflammation associated with, acute allergic asthma in a mouse ovalbumin (OVA) model. Here, we investigated the ability of (R)-DOI to reverse inflammation and symptoms associated with established asthma in a newly developed model of chronic asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.116790DOI Listing
November 2019

Characteristics and circumstances of death related to new psychoactive stimulants and hallucinogens in Australia.

Drug Alcohol Depend 2019 Nov 13;204:107556. Epub 2019 Sep 13.

National Drug and Alcohol Research Centre, University of New South Wales, NSW, 2052, Australia; School of Psychiatry, University of New South Wales, NSW, 2052, Australia; School of Psychology, University of Wollongong, Northfields Ave Wollongong, NSW, 2522, Australia.

Background: New psychoactive stimulants and hallucinogens comprise a range of "designer drugs" that have risen to prominence in the 21 century. The study aimed to: 1. Determine the characteristics, and circumstances of death, of all recorded cases of new psychoactive stimulant and hallucinogen-related death in Australia; 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2019.107556DOI Listing
November 2019
4 Reads

MDMA-Associated Liver Toxicity: Pathophysiology, Management, and Current State of Knowledge.

AACN Adv Crit Care 2019 ;30(3):232-248

Ruff Joseph Macale Cajanding is Charge Nurse, Adult Critical Care Unit, 6th Floor, King George V Building, St. Bartholomew's Hospital, Barts Health NHS Trust, 2 King Edward Street, London EC1A 1HQ, United Kingdom

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) has become a popular recreational drug of abuse among young adults, partly because of the belief that it is relatively safe compared with other drugs with the same stimulant and hallucinogenic effects. However, MDMA use has been associated with a wide spectrum of organ toxicities, with the liver being severely affected by its deleterious effects. This article discusses the essential pharmacology of MDMA and describes the effects MDMA has on various organ systems of the body, with particular focus on the liver. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4037/aacnacc2019852DOI Listing
February 2020
3 Reads

False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology.

J Anal Toxicol 2020 Mar;44(2):200-205

Service de Toxicologie, Hôpital Lariboisière, AP-HP, 2 Rue Ambroise Paré, Paris 75010, France.

Amphetamines, frequently used recreational drugs with high risk of toxicity, are commonly included in urine drug screens. This screening is based on enzyme immunoassay, which is a quick and easy-to-perform technique, but may lack specificity resulting from cross-reactivity with other compounds, causing false positive results. We present two cases of presumed false positive MULTIGENT® amphetamine/methamphetamine and MULTIGENT® ecstasy (Abbott®) immunoassays with the beta-blocker metoprolol. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jat/advance-article/doi/10.1093/jat
Publisher Site
http://dx.doi.org/10.1093/jat/bkz051DOI Listing
March 2020
3 Reads

Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats.

BMC Pharmacol Toxicol 2019 08 5;20(1):47. Epub 2019 Aug 5.

Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.

Background: MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of present study was to determine causes for two adverse events and further test that dose and environment have a differential role in initiating and intensifying MDMA neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40360-019-0326-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683525PMC
August 2019
4 Reads

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D Receptor Mechanism of Action.

J Pharmacol Exp Ther 2019 10 1;371(1):1-14. Epub 2019 Aug 1.

Sunovion Pharmaceuticals, Marlborough, Massachusetts (N.D., P.G.J., S.C.H., R.L., L.S., J.E.C., K.L.S., T.H.L., U.C.C., K.S.K.); and PsychoGenics, Paramus, New Jersey (T.H., E.L.)

For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D receptors. Drug development of non-D compounds, seeking to avoid the limiting side effects of dopamine receptor blockade, has failed to date to yield new medicines for patients. In this work, we report the discovery of SEP-363856 (SEP-856), a novel psychotropic agent with a unique mechanism of action. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.119.260281DOI Listing
October 2019
3 Reads

Metabolism of lysergic acid diethylamide (LSD): an update.

Drug Metab Rev 2019 08 16;51(3):378-387. Epub 2019 Jul 16.

Department of Sciences, INFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL , Gandra , Portugal.

Lysergic acid diethylamide (LSD) is the most potent hallucinogen known and its pharmacological effect results from stimulation of central serotonin receptors (5-HT). Since LSD is seen as physiologically safe compound with low toxicity, its use in therapeutics has been renewed during the last few years. This review aims to discuss LSD metabolism, by presenting all metabolites as well as clinical and toxicological relevance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03602532.2019.1638931DOI Listing
August 2019
8 Reads

A case of fatal 2,4-dinitrophenol (2,4-DNP) intoxication with delayed onset methaemoglobinaemia.

Authors:
Johan Duflou

Pathology 2019 Aug 18;51(5):548-549. Epub 2019 Jun 18.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, NSW, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pathol.2019.03.006DOI Listing
August 2019
6 Reads

Long-term treatment with 3,4-methylenedioxymethamphetamine caused retina damage in C57BL/6 mice.

Arq Bras Oftalmol 2019 06 3;82(5):363-371. Epub 2019 Jun 3.

Department of Ophthalmology, Beijing Changping Hospital of Integrated Chinese and Western Medicine, Beijing 102208, People's Republic of China.

Purpose: As a class of psychostimulant drugs, amphetamines are widely abused for their stimulant, euphoric, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Following the onset of these effects, 3,4 methylenedioxymethamphetamine produces persistent damage to dopamine and serotonin nerve terminals, resulting in long-lasting neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5935/0004-2749.20190070DOI Listing
June 2019
11 Reads

Rhynchophylline Attenuates Neurotoxicity in Tourette Syndrome Rats.

Neurotox Res 2019 Nov 21;36(4):679-687. Epub 2019 May 21.

Nanjing University of Chinese Medicine, Nanjing, 210046, China.

Tourette syndrome (TS) is a chronic neuropsychiatric disorder with clinical manifestations of involuntary and repeated muscle twitching and vocal twitching. The drugs used to treat TS are relatively limited. The aim of this study was to investigate the effects of rhynchophylline (RH) and the underlying mechanism in 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced neurotoxicity in a TS rat model. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12640-019-00059-1
Publisher Site
http://dx.doi.org/10.1007/s12640-019-00059-1DOI Listing
November 2019
5 Reads

Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenarios.

Neurotoxicology 2019 09 9;74:28-39. Epub 2019 May 9.

Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

The use of new psychoactive substances (NPS) is increasing despite associated health risks and limited pharmacological and toxicological knowledge. Information is available mainly for acute effects on specific targets like monoamine transporters and receptors. Recently, we have shown the ability of several NPS and illicit drugs to modulate neuronal activity during acute exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2019.05.004DOI Listing
September 2019
3 Reads

MDMA Induced Cardio-toxicity and Pathological Myocardial Effects: A Systematic Review of Experimental Data and Autopsy Findings.

Cardiovasc Toxicol 2019 12;19(6):493-499

Department of Legal and Forensic Medicine, University of Genova, Via Antonio De Toni 12, 16132, Genoa, Italy.

3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of being a "safe" drug, the actual scientific data denote that it actually leaves a trail of cardio-toxicity, above and beyond its neurotoxicity and other somatic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12012-019-09526-9DOI Listing
December 2019
12 Reads

Δ9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts.

Reprod Toxicol 2019 08 1;87:21-31. Epub 2019 May 1.

Department of Physiology and Pharmacology, Western University, London, Ontario, Canada; Departments of Obstetrics and Gynecology, Children's Health Research Institute, Lawson, Health Research Institute, Western University, London, Ontario, Canada. Electronic address:

While studies have demonstrated that the main psychoactive component of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC) alone induces placental insufficiency and fetal growth restriction, the underlying mechanisms remain elusive. Given that both (i) endoplasmic reticulum (ER) stress in pregnancy and (ii) gestational exposure to Δ9-THC leads to placental deficiency, we hypothesized that Δ9-THC may directly induce placental ER stress, influencing trophoblast gene expression and mitochondrial function. BeWo human trophoblast cells treated with Δ9-THC (3-30 μM) led to a dose-dependent increase in all ER stress markers and CHOP; these effects could be blocked with CB1R/CB2R antagonists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2019.04.008DOI Listing
August 2019
3 Reads

Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia.

Int J Mol Sci 2019 May 1;20(9). Epub 2019 May 1.

Biology Department, Macalester College, Saint Paul, MN 55105, USA.

Vulvodynia is a remarkably prevalent chronic pain condition of unknown etiology. An increase in numbers of vulvar mast cells often accompanies a clinical diagnosis of vulvodynia and a history of allergies amplifies the risk of developing this condition. We previously showed that repeated exposures to oxazolone dissolved in ethanol on the labiar skin of mice led to persistent genital sensitivity to pressure and a sustained increase in labiar mast cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20092163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539044PMC
May 2019
2 Reads

Harmine shows therapeutic activity on nicotine-induced liver failure in mice.

Histol Histopathol 2019 Oct 3;34(10):1185-1193. Epub 2019 May 3.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

This experiment evaluated the effects of harmine against nicotine-induced damage to the liver of mice. Nicotine is a major toxic component of cigarette smoke and a major risk factor for functional disorders in the liver, because it induces oxidative stress. Harmine is a harmal-derived alkaloid with therapeutic and antioxidant properties. Read More

View Article

Download full-text PDF

Source
http://www.hh.um.es/Abstracts/Vol_/_/__18122.htm
Publisher Site
http://dx.doi.org/10.14670/HH-18-122DOI Listing
October 2019
173 Reads
2.096 Impact Factor

Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.

Neurotoxicol Teratol 2019 Jul - Aug;74:106806. Epub 2019 Apr 24.

Department of Obstetrics and Gynecology, Duke University Medical Center, USA.

Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure during gestation is very well established. In contrast, the impacts of paternal toxicant exposure on offspring neurobehavioral function are much less well studied. A vector for paternal toxicant exposure on development of his offspring has been identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ntt.2019.04.003DOI Listing
May 2020
2 Reads

DNA Damaging Effects, Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ-Tetrahydrocannabinol.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Institute for Medical Research and Occupational Health, Zagreb HR-10001, Croatia.

Currently we are faced with an ever-growing use of Δ-tetrahydrocannabinol (THC) preparations, often used as supportive therapies for various malignancies and neurological disorders. As some of illegally distributed forms of such preparations, like cannabis oils and butane hash oil, might contain over 80% of THC, their consumers can become intoxicated or experience various detrimental effects. This fact motivated us for the assessments of THC toxicity in vivo on a Wistar rat model, at a daily oral dose of 7 mg/kg which is comparable to those found in illicit preparations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24081560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515386PMC
April 2019
5 Reads

Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018 - A potential risk to users?

Drug Test Anal 2019 Aug 15;11(8):1172-1182. Epub 2019 May 15.

Analytical Services International, St. George's University of London, Cranmer Terrace, London, UK.

3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) tablets are widely used recreationally, and not only vary in appearance, but also in MDMA content. Recently, the prevalence of high-content tablets is of concern to public health authorities. To compare UK data with other countries, we evaluated MDMA content of 412 tablets collected from the UK, 2001-2018, and investigated within-batch content variability for a sub-set of these samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dta.2605DOI Listing
August 2019
6 Reads

Blonanserin ameliorates social deficit through dopamine-D receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.

Neurochem Int 2019 09 16;128:127-134. Epub 2019 Apr 16.

Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy, Meijo University, Nagoya, 468-8503, Japan; Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Nagoya, 468-8503, Japan; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8560, Japan. Electronic address:

Blonanserin differs from other antipsychotic drugs, such as risperidone and olanzapine, and exhibits a higher affinity for dopamine-D receptors than for serotonin 5-HT receptors. We investigated the involvement of dopamine-D receptors in the effect of blonanserin on the social deficit observed in an animal model of schizophrenia and sought to elucidate the molecular mechanism underlying its action. Mice received phencyclidine (PCP: 10 mg/kg/day, s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.04.008DOI Listing
September 2019
1 Read

Potential Pharmacokinetic Drug⁻Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive -Methyl-d-Aspartate Receptor Antagonist.

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rood, Shanghai 201203, China.

Harmine (HAR) is a beta-carboline alkaloid widely distributed in nature. It exhibits psychopharmacological effects of improving learning and memory. However, excessive dose of HAR can cause central tremor toxicity, which may be related to the glutamate system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24071430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479946PMC
April 2019
6 Reads

Enhancement of organic pollutants bio-decontamination from aqueous solution using newly-designed Pseudomonas putida-GA/MIL-100(Fe) bio-nanocomposites.

Environ Res 2019 06 23;173:237-245. Epub 2019 Mar 23.

Collaborative Innovation Center of Suzhou Nano Science and Technology, College of Chemistry Chemical Engineering and Materials Science Soochow University, 199 Ren'ai Road, Suzhou, 215123, PR China. Electronic address:

As a natural adsorption material, graphene has become a hot research topic in water treatment due to its unique framework, large surface area, low cost, and simple preparation. Here, a series of composite material aerogels (GA/MIL-100(Fe)) consisting of Fe metal-organic frameworks (MIL-100 (Fe)) and graphene-based aerogel (GA) were prepared through a hydrothermal and step-by-step strategy and used for the adsorption of an azo dye in wastewater, scilicet acid orange 10 (AO10). The adsorption equilibrium of AO10 solutions with concentrations of 50 and 100 mg/L was reached within 45 min but the dye could not be fully removed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2019.03.052DOI Listing
June 2019
4 Reads

Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys.

Psychopharmacology (Berl) 2019 Jul 25;236(7):2223-2232. Epub 2019 Mar 25.

Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Rationale: Phencyclidine (PCP) could induce schizophrenia (Sz) like behavior in both humans and animals, therefore, has been widely utilized to establish Sz animal models. It induced cognitive deficits, the core symptom of Sz, mainly through influencing frontal dopaminergic function. Nonhuman primate (NHP) studies demonstrated impaired object retrieval detour (ORD) and spatial delayed response (SDR) task performance by acute or chronic PCP treatment. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00213-019-05214-2
Publisher Site
http://dx.doi.org/10.1007/s00213-019-05214-2DOI Listing
July 2019
31 Reads

Promoting cannabis products to pharmaceutical drugs.

Eur J Pharm Sci 2019 Apr 7;132:118-120. Epub 2019 Mar 7.

Institute of Plant Science, Agriculture Research Organization, Volcani Center, Rishon LeZion 7528809, Israel.

Cannabis sativa is widely used for medical purposes. However, to date, aroma, popular strain name or the content of two phytocannabinoids-Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD) are mostly considered for therapeutic activity. This is despite the hundreds of compounds in this plant and their potential synergistic interactions in mixtures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2019.02.027DOI Listing
April 2019
35 Reads

Serotonin syndrome unmasking thyrotoxicosis.

BMJ Case Rep 2019 Mar 7;12(3). Epub 2019 Mar 7.

Renal/General Medicine, Mercy University Hospital, Cork, Ireland.

A 26-year-old cachectic man presented with an altered mental status. He was agitated, tremulous, hyperthermic and diaphoretic with largely dilated pupils. Collateral history revealed acute ingestion of 3,4-methylenedioxymethamphetamine on a background of chronic drug abuse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228404DOI Listing
March 2019
12 Reads

Syrian rue seeds interacted with acacia tree bark in an herbal stew resulted in N,N-dimethyltryptamine poisoning.

Clin Toxicol (Phila) 2019 Oct 4;57(10):867-869. Epub 2019 Mar 4.

d Department of Emergency Medicine, Chang Gung Memorial Hospital , Keelung , Taiwan.

Illicit substance use is an increasing problem all over the world, especially in adolescents and young adults. It is a challenge to make a definitive diagnosis of a specific substance in a poisoning case without toxicology laboratory confirmation. We confirmed the presence of N,N-dimethyltryptamine (DMT) by liquid chromatograph tandem mass spectrometer (LC/MS/MS) in biologic samples from two patients who presented with signs and symptoms consistent with sympathomimetic toxicity following the consumption of an herbal stew. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2019.1576877DOI Listing
October 2019
27 Reads

Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis.

Biochem Pharmacol 2019 05 27;163:321-334. Epub 2019 Feb 27.

Maimonides Biomedical Research Institute of Córdoba, Spain; Departament of Cellular Biology, Physiology and Immunology, University of Córdoba, Spain; Universitary Hospital Reina Sofía, Córdoba, Spain. Electronic address:

The endocannabinoid system (ECS) may play a role in the pathophysiology of systemic sclerosis (SSc). Cannabinoids acting as dual PPARγ/CB agonists, such as VCE-004.8 and Ajulemic acid (AjA), have been shown to alleviate skin fibrosis and inflammation in SSc models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2019.02.029DOI Listing
May 2019
2 Reads

The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.

Mol Nutr Food Res 2019 05 27;63(10):e1801177. Epub 2019 Mar 27.

Department of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut (MRI), Federal Research Institute of Nutrition and Food, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany.

Scope: Heterocyclic aromatic amines (HAAs) are process-induced food contaminants with high mutagenic and/or carcinogenic potential. Although the human gut microbiota is known to affect the metabolism of dietary constituents, its impact on HAA metabolism and toxicity has been little studied. Here, the glycerol-dependent metabolism of seven foodborne HAAs (AαC, Trp-P-1, harman, norharman, PhIP, MeIQx, and MeIQ) by the human fecal microbiota is investigated. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.2018011
Publisher Site
http://dx.doi.org/10.1002/mnfr.201801177DOI Listing
May 2019
5 Reads

25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In Vitro.

Neurotox Res 2019 May 26;35(4):993-998. Epub 2019 Feb 26.

Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.

25C-NBOMe is a designer substituted phenethylamine and a high-potency psychedelic that acts on the 5-HT receptor. Although 25C-NBOMe overdoses have been related to several deaths in the USA and Europe, very limited data exists on the in vitro neurotoxicity of 25C-NBOMe. In this study, we found that 25C-NBOMe potently reduced cell viability of SH-SY5Y, PC12, and SN4741 cells, with IC values of 89, 78, and 62 μM, respectively. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12640-019-0012-x
Publisher Site
http://dx.doi.org/10.1007/s12640-019-0012-xDOI Listing
May 2019
51 Reads

Gastrodin attenuates neuroinflammation in DOI-induce Tourette syndrome in rats.

J Biochem Mol Toxicol 2019 May 20;33(5):e22302. Epub 2019 Feb 20.

Nanjing University of Chinese Medicine, Nanjing, China.

Objective: Tourette syndrome (TS) is a chronic neuropsychiatric disorder. Its clinical manifestations are involuntary and recurrent muscle twitch, resulting in motor twitch and occurrence twitch. Traditional Chinese medicine has obvious advantages in treating TS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbt.22302DOI Listing
May 2019
8 Reads

Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia.

Neurochem Int 2019 05 5;125:1-6. Epub 2019 Feb 5.

Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Japanese Drug Organization of Appropriate Use and Research, 3-1509 Omoteyama, Tenpaku-ku, Nagoya, Aichi 468-0069, Japan; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Phencyclidine (PCP) is a dissociative anesthetic that induces psychotic symptoms and neurocognitive deficits in rodents similar to those observed in schizophrenia patients. PCP administration in healthy human subjects induces schizophrenia-like symptoms such as positive and negative symptoms, and a range of cognitive deficits. It has been reported that PCP, ketamine, and related drugs such as N-methyl-D-aspartate-type (NMDA) glutamate receptor antagonists, induce behavioral effects by blocking neurotransmission at NMDA receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.001DOI Listing
May 2019
18 Reads

Continuation of structure-activity relationship study of novel benzamide derivatives as potential antipsychotics.

Arch Pharm (Weinheim) 2019 Apr 31;352(4):e1800306. Epub 2019 Jan 31.

University of Chinese Academy of Sciences, Beijing, China.

A series of benzamide derivatives possessing potent dopamine D , serotonin 5-HT , and 5-HT receptor properties were synthesized and evaluated as potential antipsychotics. Among them, 5-(4-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)butoxy)-N-cyclopropyl-2-fluorobenzamide (4k) held the best pharmacological profile. It not only exhibited potent and balanced activities for the D , 5-HT , and 5-HT receptors, but was also endowed with low to moderate activities for the 5-HT , H , and M receptors, suggesting a low propensity for inducing weight gain or diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ardp.201800306DOI Listing
April 2019
7 Reads
1.396 Impact Factor

Cannabinoid toxicity in pediatrics.

Curr Opin Pediatr 2019 04;31(2):256-261

Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Purpose Of Review: The advent of legalized cannabis in multiple regions of the United States has rendered the drug more accessible to pediatric patients. Pediatricians and Pediatric Emergency Medicine Providers face new challenges in counseling both patients and their parents, diagnosing exploratory ingestions of cannabinoids in toddlers, and managing complications of prolonged, heavy cannabis use in adolescents. The purpose of this review article is to provide clinicians a succinct summary of recent literature regarding tetrahydrocannabinol (THC) pharmacokinetics, pharmacodynamics, impacts on development, as well as presentations of acute and chronic toxicity. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00008480-900000000-9889
Publisher Site
http://dx.doi.org/10.1097/MOP.0000000000000739DOI Listing
April 2019
62 Reads