2,275 results match your criteria Toxicity Hallucinogen


Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.

Toxicol Lett 2019 Feb 19;301:79-89. Epub 2018 Nov 19.

Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany. Electronic address:

New psychoactive substances (NPS) are still an emerging issue in clinical and forensic toxicology. Information about their cytotoxic potential is limited or even unavailable before distribution and thus their intake can be of high risk for consumers. The aim of the presented study was to develop a strategy to identify cytotoxic potential of NPS based on a high content screening assay (HCSA) using HepG2 cell line and four fluorescent dyes, namely Hoechst33342, TMRM, CAL-520, and TOTO-3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.11.007DOI Listing
February 2019
22 Reads

Long-term systemic administration with low dose of 3,4-methylenedioxymethamphetamine causes photoreceptor cell damage in CD1 mice.

Cutan Ocul Toxicol 2019 Mar 26;38(1):81-87. Epub 2018 Nov 26.

b Department of Ophthalmology , Shenzhen Children's Hospital , Shenzhen , People's Republic of China.

Objective: As a powerful psychostimulant with high potential for abuse, 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting neurotoxicity. This study was to investigate the effects of systemic administration of MDMA on retinal damage in CD1 mice and its underlying mechanisms.

Material And Methods: CD1 mice were randomly divided into two groups (n = 10): group 1 receiving PBS by intraperitoneal injection daily; group 2 receiving 2 mg/kg MDMA by intraperitoneal injection daily for 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2018.1539007DOI Listing
March 2019
2 Reads

Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT receptors.

Biochem Pharmacol 2018 Dec 25;158:27-34. Epub 2018 Sep 25.

Research Service, VA Portland Health Care System, Portland, OR 97239, United States; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States; Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, United States; The Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR 97239, United States.

The use of new psychoactive substituted 2,5-dimethoxy-N-benzylphenethylamines is associated with abuse and toxicity in the United States and elsewhere and their pharmacology is not well known. This study compares the mechanisms of action of 2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe), 2-(4-ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25E-NBOMe), 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25H-NBOMe), 2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol (25I-NBOH); and 2-(2,5-dimethoxy-4-nitrophenyl)-N-(2-methoxybenzyl)ethanamine) (25N-NBOMe) with hallucinogens and stimulants. Mammalian cells heterologously expressing 5-HT, 5-HT, 5-HT or 5-HT receptors, or dopamine, serotonin or norepinephrine transporters (DAT, SERT and NET, respectively) were used to assess drug affinities at radioligand binding sites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2018.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298744PMC
December 2018
13 Reads

Effect of cannabidiolic acid and ∆-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain.

Psychopharmacology (Berl) 2018 Nov 17;235(11):3259-3271. Epub 2018 Sep 17.

Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G2W1, Canada.

Rationale: Cannabidiol (CBD), a non-intoxicating component of cannabis, or the psychoactive Δ-tetrahydrocannabiol (THC), shows anti-hyperalgesia and anti-inflammatory properties.

Objectives: The present study evaluates the anti-inflammatory and anti-hyperalgesia effects of CBD's potent acidic precursor, cannabidiolic acid (CBDA), in a rodent model of carrageenan-induced acute inflammation in the rat hind paw, when administered systemically (intraperitoneal, i.p. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00213-018-5034-1
Publisher Site
http://dx.doi.org/10.1007/s00213-018-5034-1DOI Listing
November 2018
4 Reads

Does getting high hurt? Characterization of cases of LSD and psilocybin-containing mushroom exposures to national poison centers between 2000 and 2016.

J Psychopharmacol 2018 Dec 5;32(12):1286-1294. Epub 2018 Sep 5.

Maryland Poison Center, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD, USA.

Background:: Lysergic acid diethylamide (LSD) and psilocybin are serotonergic hallucinogens that are used primarily for recreational abuse. Small studies evaluated the efficacy of LSD and psilocybin for several psychiatric conditions. There are limited safety or toxicity data for either of these substances, especially in large populations. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0269881118793086
Publisher Site
http://dx.doi.org/10.1177/0269881118793086DOI Listing
December 2018
12 Reads

Effects of Δ-tetrahydrocannabinol on irinotecan-induced clinical effects in rats.

Chem Biol Interact 2018 Oct 18;294:128-134. Epub 2018 Aug 18.

Institute for Medical Research and Occupational Health, Zagreb, Croatia. Electronic address:

Because of the great interest for research on the potential use of cannabis preparations as co-medication for alleviation of toxic effects in cancer management, we investigated the influence of Δ-tetrahydrocannabinol (Δ-THC) to modulate irinotecan (CPT-11)-induced toxicity. Male Wistar rats were treated either with a single irinotecan intraperitoneal dose, 100 mg/kg body-weight (b.w. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2018.08.009DOI Listing
October 2018
8 Reads

TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.

Neuropsychopharmacology 2018 11 23;43(12):2468-2477. Epub 2018 Jul 23.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS), and other neuropsychiatric disorders. Some evidence suggests that TPA-023, (7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b] pyridazine), a GABA α2,3 subtype-selective GABA partial agonist and α antagonist, and the neurosteroid, pregnenolone sulfate, a GABA antagonist, may improve CIAS in pilot clinical trials. The goal of this study was to investigate the effect of TPA-023 in mice after acute or subchronic (sc) treatment with the N-methyl-D-aspartate receptor (NMDAR) antagonist, phencyclidine (PCP), on novel object recognition (NOR), reversal learning (RL), and locomotor activity (LMA) in rodents. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41386-018-0160-3
Publisher Site
http://dx.doi.org/10.1038/s41386-018-0160-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180114PMC
November 2018
14 Reads

5-HT parital agonism and 5-HT antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA.

Psychopharmacology (Berl) 2018 Oct 31;235(10):2795-2808. Epub 2018 Jul 31.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward Building 7-014, Chicago, IL, 60611, USA.

Rationale: The effect of atypical antipsychotic drugs (AAPDs), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (CIAS), has been suggested to be due, in part, to enhancing release of dopamine (DA), acetylcholine (ACh), and glutamate (Glu) in cortex and hippocampus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-018-4972-yDOI Listing
October 2018
13 Reads

Mushroom poisoning epidemiology in the United States.

Mycologia 2018 Jul-Aug;110(4):637-641. Epub 2018 Jul 31.

c Pediatric Intensive Care Unit, Saint Luke's Hospital , 190 E Bannock Street, Boise , Idaho 83712.

Ingestion of wild and potentially toxic mushrooms is common in the United States and many other parts of the world. US poison centers have been logging cases of mushroom exposure in The National Poison Data System (NPDS) annual publications for over 30 years. This study compiles and analyzes US mushroom exposures as reported by the NPDS from 1999 to 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00275514.2018.1479561DOI Listing
January 2019
33 Reads

Psychedelic Fauna for Psychonaut Hunters: A Mini-Review.

Front Psychiatry 2018 22;9:153. Epub 2018 May 22.

Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

Currently different classes of psychoactive substances are available for abuse, including several hundred novel psychoactive substances (NPS). Some of these drugs occur naturally in plants and animals or are chemically modified from plant or animal compounds and have been abused by humans over millennia. Recently, the occurrence of a new "drug culture" (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2018.00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992390PMC
May 2018
10 Reads

The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters.

Neuropharmacology 2018 08 23;138:282-291. Epub 2018 Jun 23.

Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Währingerstraße 13A, 1090, Vienna, Austria; Center for Addiction Research and Science, Medical University Vienna, Waehringerstrasse 13A, 1090 Vienna, Austria. Electronic address:

(±)-cis-4,4'-Dimethylaminorex (4,4'-DMAR) is a new psychoactive substance (NPS) that has been associated with 31 fatalities and other adverse events in Europe between June 2013 and February 2014. We used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-DMAR on human high-affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT). In addition, we assessed its binding affinities to monoamine receptors and transporters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2018.06.018DOI Listing
August 2018
6 Reads

Irinotecan and Δ⁸-Tetrahydrocannabinol Interactions in Rat Liver: A Preliminary Evaluation Using Biochemical and Genotoxicity Markers.

Molecules 2018 Jun 1;23(6). Epub 2018 Jun 1.

Institute for Medical Research and Occupational Health, HR-10001 Zagreb, Croatia.

There is growing interest regarding the use of herbal preparations based on for medicinal purposes, despite the poorly understood interactions of their main constituent Δ⁸-tetrahydrocannabinol (THC) with conventional drugs, especially cytostatics. The objective of this pilot study was to prove whether the concomitant intake of THC impaired liver function in male Wistar rats treated with the anticancer drug irinotecan (IRI), and evaluate the toxic effects associated with this exposure. IRI was administered once intraperitoneally (at 100 mg/kg of the body weight (b. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules23061332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100385PMC
June 2018
23 Reads

Reduced type III neuregulin 1 expression does not modulate the behavioural sensitivity of mice to acute Δ-tetrahydrocannabinol (D-THC).

Pharmacol Biochem Behav 2018 07 8;170:64-70. Epub 2018 May 8.

Neuroscience Research Australia (NeuRA), Randwick, Australia; School of Medicine, Western Sydney University, Campbelltown, Australia. Electronic address:

Mice with a mutation in the transmembrane domain of the schizophrenia risk gene, neuregulin 1 (Nrg1 TM HET), are more susceptible to the neuro-behavioural effects of Δ-tetrahydrocannabinol (D-THC), the principal psychoactive component in cannabis. However, NRG1 is transcriptionally complex with over 30 different isoforms, most of which carry a transmembrane domain, raising the question which NRG1 isoform(s) may contribute to this phenotype. Type III NRG1/Nrg1 is the most brain abundant isoform and brain studies have identified increased levels of type III NRG1 mRNA in humans carrying a NRG1 risk haplotype for schizophrenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbb.2018.05.003DOI Listing
July 2018
8 Reads

Phencyclidine and Scopolamine for Modeling Amnesia in Rodents: Direct Comparison with the Use of Barnes Maze Test and Contextual Fear Conditioning Test in Mice.

Neurotox Res 2018 Oct 21;34(3):431-441. Epub 2018 Apr 21.

Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna St., 30 - 688, Krakow, Poland.

Nowadays cognitive impairments are a growing unresolved medical issue which may accompany many diseases and therapies, furthermore, numerous researchers investigate various neurobiological aspects of human memory to find possible ways to improve it. Until any other method is discovered, in vivo studies remain the only available tool for memory evaluation. At first, researchers need to choose a model of amnesia which may strongly influence observed results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-018-9901-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154175PMC
October 2018
3 Reads

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity.

Psychopharmacology (Berl) 2018 05 11;235(5):1593-1607. Epub 2018 Apr 11.

Allergan, Madison, NJ, USA.

Rationale: Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry.

Objectives: The study aims to compare the effects of cariprazine and aripiprazole on PCP-induced changes in the extracellular levels of glutamate, dopamine, serotonin, noradrenaline, and GABA in the rat medial prefrontal cortex (mPFC), and on locomotor activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-018-4874-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920013PMC
May 2018
10 Reads

Repeated Administration of 3,4-Methylenedioxymethamphetamine (MDMA) Elevates the Levels of Neuronal Nitric Oxide Synthase in the Nigrostriatal System: Possible Relevance to Neurotoxicity.

Neurotox Res 2018 Nov 9;34(4):763-768. Epub 2018 Apr 9.

Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Building A, Monserrato University Campus, SP 8, Km 0.700, 09042, Monserrato, Italy.

Previous studies have consistently demonstrated that the amphetamine-related drug 3,4-methylenedioxymethamphetamine (MDMA) induces dopaminergic damage in the mouse brain, and that this effect is most marked in the nigrostriatal system. Moreover, it has been suggested that the overproduction of nitric oxide (NO) may participate in the dopaminergic damage induced by MDMA. To further elucidate this issue, we evaluated the levels of the enzyme nitric oxide synthase (nNOS), which catalyzes the production of NO, in mice treated with regimens of MDMA that induce progressive and persistent neurotoxicity in the dopaminergic nigrostriatal system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-018-9892-4DOI Listing
November 2018
4 Reads

Rewarding and reinforcing effects of 4-chloro-2,5-dimethoxyamphetamine and AH-7921 in rodents.

Neurosci Lett 2018 05 5;676:66-70. Epub 2018 Apr 5.

Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.

New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2018.04.009DOI Listing
May 2018
6 Reads

Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA).

Neurotoxicology 2018 05 20;66:87-97. Epub 2018 Mar 20.

Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

While the prevalence and the use of new psychoactive substances (NPS) is steadily increasing, data on pharmacological, toxicological and clinical effects is limited. Considering the large number of NPS available, there is a clear need for efficient in vitro screening techniques that capture multiple mechanisms of action. Neuronal cultures grown on multi-well microelectrode arrays (mwMEAs) have previously proven suitable for neurotoxicity screening of chemicals, pharmaceuticals and (illicit) drugs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0161813X183008
Publisher Site
http://dx.doi.org/10.1016/j.neuro.2018.03.007DOI Listing
May 2018
15 Reads

Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens.

J Anal Toxicol 2018 Sep;42(7):437-445

Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, USA.

The number of emerging novel stimulants modified based on beta-keto variations of amphetamine-like substances continues to rise. Dibutylone reports described in the medical and toxicological literature are limited, therefore little information is available in terms of quantitative confirmation or metabolism. During this study, authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver were quantitatively and qualitatively analyzed for the presence of dibutylone and butylone, with paired case history and demographic information. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jat/bky022DOI Listing
September 2018
5 Reads

Cytotoxic and Apoptotic Activity of the Novel Harmine Derivative ZC-14 in Sf9 Cells.

Int J Mol Sci 2018 Mar 11;19(3). Epub 2018 Mar 11.

Key Laboratory of Crop Integrated Pest Management in South China, Ministry of Agriculture, South China Agricultural University, Guangzhou 510642, China.

Harmine, one of the natural β-carboline alkaloids extracted from L., exhibits broad spectrum but limited insecticidal ability against many pests. So there is an urgent need to synthesize novel derivatives with high efficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19030811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877672PMC
March 2018
6 Reads

Maternal and developmental toxicity of the hallucinogenic plant-based beverage ayahuasca in rats.

Reprod Toxicol 2018 04 6;77:143-153. Epub 2018 Mar 6.

Laboratory of Toxicology, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil. Electronic address:

Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. Rats treated with 4X and 8X doses died during the treatment period (44 and 52%), and those that survived showed kidney injury. Rats surviving the 8X dose showed neuronal loss in hippocampal regions and in the raphe nuclei, and those from the 2X dose neuronal loss in CA1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2018.03.002DOI Listing
April 2018
8 Reads

Suppression of Non-Small Cell Lung Cancer Growth and Metastasis by a Novel Small Molecular Activator of RECK.

Cell Physiol Biochem 2018 28;45(5):1807-1817. Epub 2018 Feb 28.

Research Center of Basic Medical Sciences, School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, China.

Background/aims: Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a novel tumor suppressor gene that is critical for regulating tumor cell invasion and metastasis. The expression of RECK is dramatically down-regulated in human cancers. Harmine, a tricyclic compound from Peganum harmala, has been shown to have potential anti-cancer activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487872DOI Listing
May 2018
17 Reads

Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.

Biochem Biophys Res Commun 2018 03 1;498(1):99-104. Epub 2018 Mar 1.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address:

Harmine and its analogs have long been considered as anticancer agents. In vitro analyses suggested that intercalating DNA or inhibiting topoisomerase might contribute to the cytotoxic effect of this class of compound. However, this idea has not been rigorously tested in intact cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2018.02.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857254PMC
March 2018
7 Reads

The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task.

Psychopharmacology (Berl) 2018 05 22;235(5):1403-1414. Epub 2018 Feb 22.

Gedeon Richter Plc, Budapest, Hungary.

Rationale: Attentional processing deficits are a core feature of schizophrenia, likely contributing to the persistent functional and occupational disability observed in patients with schizophrenia. The pathophysiology of schizophrenia is hypothesized to involve dysregulation of NMDA receptor-mediated glutamate transmission, contributing to disruptions in normal dopamine transmission. Preclinical investigations often use NMDA receptor antagonists, such as phencyclidine (PCP), to induce cognitive disruptions relevant to schizophrenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-018-4857-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920008PMC
May 2018
4 Reads

Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test.

Neuroreport 2018 04;29(6):447-452

Anesthesiology and Perioperative Medicine.

Cannabinoids have shown promise for the treatment of intractable pain states and may represent an alternative pharmacotherapy for pain management. A growing body of clinical evidence suggests a role for sex in pain perception and in cannabinoid response. We examined cannabinoid sensitivity and tolerance in male and female mice expressing a desensitization-resistant form (S426A/S430A) of the cannabinoid type 1 receptor (CB1R). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNR.0000000000000993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112616PMC
April 2018
2 Reads

Melatonin attenuates Δ-tetrahydrocannabinol-induced reduction in rat sperm motility and kinematics in-vitro.

Reprod Toxicol 2018 04 14;77:62-69. Epub 2018 Feb 14.

Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Kwara, Nigeria.

The use of Cannabis sativa (CS) has been widely demonstrated to have detrimental effect on male reproductive functions. Despite the well-known existence of endocannabinoid and melatonergic systems in semen, the physiological significance of their interaction is not understood. We recently showed that melatonin exacerbates the CS-induced gonadotoxicity in-vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2018.02.005DOI Listing
April 2018
8 Reads

Encephalopathy after chocolate consumption.

Med J Aust 2018 02;208(3):110

Concord Repatriation General Hospital, Sydney, NSW.

View Article

Download full-text PDF

Source
February 2018
5 Reads

A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects.

Eur J Pharmacol 2018 Apr 9;824:78-88. Epub 2018 Feb 9.

The Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, PR China; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

This study aims to design and synthesize a novel harmine derivative N-(4-(hydroxycarbamoyl) benzyl)-1-(4-methoxyphenyl)-9H-pyrido [3,4-b]indole-3-carboxamide (HBC) as histone deacetylase (HDAC) inhibitor, and evaluate its antitumor activities and anti-metastasis mechanism. HBC not only exerted significant ant-proliferation activity against five human cancer cell lines, especially for HepG2 cell with an IC value of 2.21 μM, which is nearly three-fold lower than SAHA (IC = 6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2018.02.004DOI Listing
April 2018
15 Reads

Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.

Neurotoxicology 2018 03;65:68-84

School of Health Sciences, Purdue University, West Lafayette, IN, 47907, United States; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, United States. Electronic address:

Heterocyclic amines (HCAs) are primarily produced during high temperature meat cooking. These compounds have been intensively investigated as mutagens and carcinogens. However, converging data suggest that HCAs may also be neurotoxic and potentially relevant to neurodegenerative diseases such as Parkinson's disease (PD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2018.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015749PMC
March 2018
3 Reads

Ghrelin Alleviates MDMA-Induced Disturbance of Serum Glucose and Lipids Levels in the Rat.

Acta Med Iran 2017 Dec;55(12):736-743

Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Hepatotoxicity is one of the clinically adverse effects of ecstasy (3, 4-methylenedioxymethamphetamine; MDMA) consumption. The detoxification tissue, liver, plays a central role in maintaining circulating levels of glucose and lipid. Hypoglycemia and hypotriglyceridemia have been reported due to ecstasy abuse. Read More

View Article

Download full-text PDF

Source
December 2017
24 Reads

A sub-set of psychoactive effects may be critical to the behavioral impact of ketamine on cocaine use disorder: Results from a randomized, controlled laboratory study.

Neuropharmacology 2018 11 5;142:270-276. Epub 2018 Jan 5.

New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, USA.

Efforts to translate sub-anesthetic ketamine infusions into widespread clinical use have centered around developing medications with comparable neurobiological activity, but with attenuated psychoactive effects so as to minimize the risk of behavioral toxicity and abuse liability. Converging lines of research, however, suggest that some of the psychoactive effects of sub-anesthetic ketamine may have therapeutic potential. Here, we assess whether a subset of these effects - the so-called mystical-type experience - mediates the effect of ketamine on craving and cocaine use in cocaine dependent research volunteers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033686PMC
November 2018
8 Reads

RhoA/MLC signaling pathway is involved in Δ⁹-tetrahydrocannabinol-impaired placental angiogenesis.

Toxicol Lett 2018 Mar 4;285:148-155. Epub 2018 Jan 4.

Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 200040, PR China. Electronic address:

Cannabis is a widely used illicit drug and its abuse during pregnancy has been related to adverse reproductive outcomes. In addition, placental angiogenesis is considered to be responsible for the transport of nutrients critical for placental development and fetal growth. The purpose of this study is to determine the effects of Δ⁹-tetrahydrocannabinol (THC), the major component of cannabis, on placental angiogenesis, involving endothelial cell (EC) proliferation, migration and tube formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2017.12.031DOI Listing
March 2018
20 Reads

Key interindividual determinants in MDMA pharmacodynamics.

Expert Opin Drug Metab Toxicol 2018 Feb;14(2):183-195

a Departments of Clinical Pharmacology and Internal Medicine , Hospital Universitari Germans Trias I Pujol-IGTP , Badalona , Spain.

Introduction: MDMA, 3,4-methylenedioxymethamphetamine, is a synthetic phenethylamine derivative with structural and pharmacological similarities to both amphetamines and mescaline. MDMA produces characteristic amphetamine-like actions (euphoria, well-being), increases empathy, and induces pro-social effects that seem to motivate its recreational consumption and provide a basis for its potential therapeutic use. Areas covered: The aim of this review is to present the main interindividual determinants in MDMA pharmacodynamics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425255.2018.1424832DOI Listing
February 2018
7 Reads

When good times go bad: managing 'legal high' complications in the emergency department.

Open Access Emerg Med 2018 20;10:9-23. Epub 2017 Dec 20.

Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Patients can use numerous drugs that exist outside of existing regulatory statutes in order to get "legal highs." Legal psychoactive substances represent a challenge to the emergency medicine physician due to the sheer number of available agents, their multiple toxidromes and presentations, their escaping traditional methods of analysis, and the reluctance of patients to divulge their use of these agents. This paper endeavors to cover a wide variety of "legal highs," or uncontrolled psychoactive substances that may have abuse potential and may result in serious toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OAEM.S120120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741979PMC
December 2017
7 Reads

Lysergic acid diethylamide causes photoreceptor cell damage through inducing inflammatory response and oxidative stress.

Cutan Ocul Toxicol 2018 Sep 19;37(3):233-239. Epub 2018 Jan 19.

a Department of Ophthalmology , Ophthalmology Hospital of Ningbo , Ningbo , People's Republic of China.

Lysergic acid diethylamide (LSD), a classical hallucinogen, was used as a popular and notorious substance of abuse in various parts of the world. Its abuse could result in long-lasting abnormalities in retina and little is known about the exact mechanism. This study was to investigate the effect of LSD on macrophage activation state at non-toxic concentration and its resultant toxicity to photoreceptor cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2018.1423620DOI Listing
September 2018
15 Reads

No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.

Eur J Clin Pharmacol 2018 Mar 2;74(3):275-283. Epub 2017 Dec 2.

Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel, University of Basel, Schanzenstrasse 55, 4056, Basel, Switzerland.

Purpose: Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α-adrenergic receptors. Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the NET gene (SLC6A2) may explain interindividual differences in the acute stimulant-type responses to MDMA in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-017-2392-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808057PMC
March 2018
13 Reads

Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication.

Psychopharmacology (Berl) 2018 03 16;235(3):709-717. Epub 2017 Nov 16.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.

Background: Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown that blockade of the 5-HT receptor nulls memory impairment during MDMA intoxication. Interestingly, studies have demonstrated that the eCB and the 5-HT system interact. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-017-4787-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847074PMC
March 2018
2 Reads

Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.

Brain Res Bull 2018 03 7;137:71-78. Epub 2017 Nov 7.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea. Electronic address:

Accumulating evidence suggests that neuroinflammation is one of the important etiologic factors of abusive and neuropsychiatric disorders. Platelet-activating factor (PAF) is potent proinflammatory lipid mediat1or and plays a pivotal role in neuroinflammatory disorders through the specific PAF receptor (PAF-R). Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2017.11.004DOI Listing
March 2018
20 Reads

Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields.

J Neurosci 2017 12 8;37(49):12031-12049. Epub 2017 Nov 8.

Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center,

We used the psychotomimetic phencyclidine (PCP) to investigate the relationships among cognitive behavior, coordinated neural network function, and information processing within the hippocampus place cell system. We report in rats that PCP (5 mg/kg, i.p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0630-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719978PMC
December 2017
11 Reads

Developmental Effects of Cannabidiol and Δ9-Tetrahydrocannabinol in Zebrafish.

Toxicol Sci 2018 03;162(1):137-145

Division of Environmental Toxicology, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677.

Cannabidiol (CBD) has gained much attention in the past several years for its therapeutic potential in the treatment of drug-resistant epilepsy, such as Dravet syndrome. Although CBD has shown anecdotal efficacy in reducing seizure frequency, little is known regarding the potential adverse side effects of CBD on physiology, development, organogenesis, or behavior. The goal of this project was to compare the relative morphological, behavioral, and gene expression phenotypes resulting after a developmental exposure to Δ9-tetrahydrocannabinol (THC) or CBD. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/toxsci/article/162/1/137/4585009
Publisher Site
http://dx.doi.org/10.1093/toxsci/kfx232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257009PMC
March 2018
16 Reads

Effects of MDMA (ecstasy) on apoptosis and heat shock protein (HSP70) expression in adult rat testis.

Toxicol Mech Methods 2018 Mar 5;28(3):219-229. Epub 2017 Nov 5.

a Department of Anatomy and Cell Biology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.

Background: This study was conducted to investigate the effects of MDMA (3,4-methylenedioxymethamphetamine, ecstasy) on apoptosis and heat shock protein expression in adult rat testis.

Methods: Twenty male rats were divided into four groups, two experimental groups (1 and 2), sham control and control. For 16 consecutive days, the experimental groups 1 and 2 were received 5 and 10 mg/kg intraperitoneal (ip) injection of ecstasy, respectively, and in the sham control group, the only saline was injected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15376516.2017.1388461DOI Listing
March 2018
10 Reads
1.550 Impact Factor

From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis elegans.

Toxicol Sci 2018 02;161(2):335-348

School of Health Sciences.

Parkinson's disease (PD) is a debilitating neurodegenerative disease. Although numerous exposures have been linked to PD etiology, causative factors for most cases remain largely unknown. Emerging data on the neurotoxicity of heterocyclic amines suggest that this class of compounds should be examined for relevance to PD. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/toxsci/article/161/2/335/4562801
Publisher Site
http://dx.doi.org/10.1093/toxsci/kfx223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837500PMC
February 2018
97 Reads
1 Citation

Studies on Para-Methoxymethamphetamine (PMMA) Metabolite Pattern and Influence of CYP2D6 Genetics in Human Liver Microsomes and Authentic Samples from Fatal PMMA Intoxications.

Drug Metab Dispos 2017 12 4;45(12):1326-1335. Epub 2017 Oct 4.

Department of Forensic Sciences, Oslo University Hospital (M.V., E.L.Ø., E.N., M.A., I.L.B.), and Institute of Clinical Medicine (M.V.), School of Pharmacy (E.L.Ø.), and Institute of Basic Medical Sciences (I.L.B.), University of Oslo, Oslo, Norway.

Para-methoxymethamphetamine (PMMA) has caused numerous fatal poisonings worldwide and appears to be more toxic than other ring-substituted amphetamines. Systemic metabolism is suggested to be important for PMMA neurotoxicity, possibly through activation of minor catechol metabolites to neurotoxic conjugates. The aim of this study was to examine the metabolism of PMMA in humans; for this purpose, we used human liver microsomes (HLMs) and blood samples from three cases of fatal PMMA intoxication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.117.077263DOI Listing
December 2017
8 Reads

Preventive effects of fructose and N-acetyl-L-cysteine against cytotoxicity induced by the psychoactive compounds N-methyl-5-(2-aminopropyl)benzofuran and 3,4-methylenedioxy-N-methamphetamine in isolated rat hepatocytes.

J Appl Toxicol 2018 Feb 26;38(2):284-291. Epub 2017 Sep 26.

Division of Toxicology, Tokyo Metropolitan Institute of Public Health, 3-24-1, Hyakunin-cho, Shinjuku-ku, Tokyo, 169-0073, Japan.

Psychoactive compounds, N-methyl-5-(2-aminopropyl)benzofuran (5-MAPB) and 3,4-methylenedioxy-N-methamphetamine (MDMA), are known to be hepatotoxic in humans and/or experimental animals. As previous studies suggested that these compounds elicited cytotoxicity via mitochondrial dysfunction and/or oxidative stress in rat hepatocytes, the protective effects of fructose and N-acetyl-l-cysteine (NAC) on 5-MAPB- and MDMA-induced toxicity were studied in rat hepatocytes. These drugs caused not only concentration-dependent (0-4 mm) and time-dependent (0-3 hours) cell death accompanied by the depletion of cellular levels of adenosine triphosphate (ATP) and glutathione (reduced form; GSH) but also an increase in the oxidized form of GSH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3523DOI Listing
February 2018
10 Reads

Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.

Behav Brain Res 2018 Jan 19;337:151-159. Epub 2017 Sep 19.

Department of Pharmacology, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 4R2, Canada; GenCanBio Inc., Canada.

It has been established that both adult and larval zebrafish are capable of showing nociceptive responses to noxious stimuli; however, the use of larvae to test novel analgesics has not been fully explored. Zebrafish larvae represent a low-cost, high-throughput alternative to traditional mammalian models for the assessment of product efficacy during the initial stages of drug development. In the current study, a novel model of nociception using zebrafish larvae is described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbr.2017.09.028DOI Listing
January 2018
4 Reads

Is 2-Hydroxypropyl-β-cyclodextrin a Suitable Carrier for Central Administration of Δ -Tetrahydrocannabinol? Preclinical Evidence.

Drug Dev Res 2017 12 18;78(8):411-419. Epub 2017 Sep 18.

Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.

Preclinical Research Δ -Tetrahydrocannabinol (THC) is a hydrophobic compound that has a potent antinociceptive effect in animals after intrathecal (IT) or intracerebroventricular (ICV) administration. The lack of a suitable solvent precludes its IT administration in humans. 2-Hydroxypropyl-β-cyclodextrin (HPβCD) increases the water solubility of hydrophobic drugs and is approved for IT administration in humans. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ddr.21413
Publisher Site
http://dx.doi.org/10.1002/ddr.21413DOI Listing
December 2017
5 Reads

Role of vasopressin V1a receptor in ∆-tetrahydrocannabinol-induced cataleptic immobilization in mice.

Psychopharmacology (Berl) 2017 Dec 14;234(23-24):3475-3483. Epub 2017 Sep 14.

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

Rationale: Cannabis is a widely used illicit substance. ∆-tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to cause catalepsy in rodents. Recent studies have shown that vasopressin V1a and V1b receptors are widely distributed in the central nervous system and are capable of influencing a wide variety of brain functions such as social behavior, emotionality, and learning and memory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-017-4735-1DOI Listing
December 2017
30 Reads

Death after 25C-NBOMe and 25H-NBOMe consumption.

Forensic Sci Int 2017 Oct 5;279:e1-e6. Epub 2017 Sep 5.

Department of Public Health, Experimental and Forensic Medicine, University of Pavia, via Forlanini, 12, 27100 Pavia, Italy.

A teenager male was found dead in a waterway after he was spotted jumping off into the water stream. The boy looked agitated and confused after a party with friends. At the gathering place, investigators seized packages of blotter papers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.forsciint.2017.08.028DOI Listing
October 2017
23 Reads

Comparing the dopaminergic neurotoxic effects of benzylpiperazine and benzoylpiperazine.

Toxicol Mech Methods 2018 Mar 28;28(3):177-186. Epub 2017 Sep 28.

a Department of Drug Discovery and Development , Harrison School of Pharmacy, Auburn University , Auburn , AL , USA.

Benzylpiperazine has been designated as Schedule I substance under the Controlled Substances Act by Drug Enforcement Administration. Benzylpiperazine is a piperazine derivative, elevates both dopamine and serotonin extracellular levels producing stimulatory and hallucinogenic effects, respectively, similar to methylenedioxymethamphetamine (MDMA). However, the comparative neurotoxic effects of Piperazine derivatives (benzylpiperazine and benzoylpiperazine) have not been elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15376516.2017.1376024DOI Listing
March 2018
14 Reads
1.550 Impact Factor