2,814 results match your criteria Toxicity Fluoride


Ambient temperature synthesis of citrate stabilized and biofunctionalized, fluorescent calcium fluoride nanocrystals for targeted labeling of cancer cells.

Biomater Sci 2013 Mar 7;1(3):294-305. Epub 2012 Nov 7.

Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi-682 041, Kerala, India.

Targeted biological contrast agents are emerging as promising candidates in the field of cancer theragnostics. Herein, we report an ambient temperature synthesis of a nanosized, antibody functionalized lanthanide doped CaF biolabel and demonstrate in vitro its potential for cancer cell targeting efficacy and specificity. Monodispersed citrate stabilized lanthanide (Eu) doped CaF nanoparticles with size ∼25 nm, exhibiting strong fluorescent emission at 612 nm, were prepared using an aqueous wet chemical route at room temperature. Read More

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http://dx.doi.org/10.1039/c2bm00127fDOI Listing

Exposures to Dental Products, Stomatological Preparations, and in Dental Care and Toothache reported to the PIC Erfurt (1997 to 2017).

Sci Rep 2020 May 15;10(1):8057. Epub 2020 May 15.

Poisons Information Centre (PIC), Erfurt, Germany.

We examined human exposures to dental products (EDP), stomatological preparations (ESP), and in the context of dental care (EDC) or toothache (ETA) registered by the Poisons Information Centre (PIC) Erfurt from 1997 to 2017. Dental products like dental technical and filling materials belong to medical devices. Stomatological preparations were classified according to the ATC code and symptom severity to the Poisoning Severity Score (PSS). Read More

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http://dx.doi.org/10.1038/s41598-020-65079-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228954PMC

Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Are Irreversible Inhibitors the Future?

Authors:
Donald E Moss

Int J Mol Sci 2020 May 13;21(10). Epub 2020 May 13.

Department of Psychology, University of Texas at El Paso, El Paso, TX 79968, USA.

Decades of research have produced no effective method to prevent, delay the onset, or slow the progression of Alzheimer's disease (AD). In contrast to these failures, acetylcholinesterase (AChE, EC 3.1. Read More

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http://dx.doi.org/10.3390/ijms21103438DOI Listing

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.

Arch Toxicol 2020 May 8;94(5):1375-1415. Epub 2020 May 8.

Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany.

Recently, epidemiological studies have suggested that fluoride is a human developmental neurotoxicant that reduces measures of intelligence in children, placing it into the same category as toxic metals (lead, methylmercury, arsenic) and polychlorinated biphenyls. If true, this assessment would be highly relevant considering the widespread fluoridation of drinking water and the worldwide use of fluoride in oral hygiene products such as toothpaste. To gain a deeper understanding of these assertions, we reviewed the levels of human exposure, as well as results from animal experiments, particularly focusing on developmental toxicity, and the molecular mechanisms by which fluoride can cause adverse effects. Read More

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http://dx.doi.org/10.1007/s00204-020-02725-2DOI Listing

Silver Diamine Fluoride in Children Using Physiologically Based PK Modeling.

J Dent Res 2020 May 6:22034520917368. Epub 2020 May 6.

Department of Pharmaceutics, University of Washington, Seattle, WA, USA.

Silver diamine fluoride (SDF) is used topically to prevent or arrest dental caries and has been tested clinically in toddlers to elderly adults. Following SDF application, small quantities of silver can be swallowed and absorbed. To monitor silver concentrations, pharmacokinetic studies can be performed. Read More

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http://dx.doi.org/10.1177/0022034520917368DOI Listing

-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells.

Int J Mol Sci 2020 Apr 18;21(8). Epub 2020 Apr 18.

Division of Clinical Pharmacology & Toxicology, University Hospital Basel, 4031 Basel, Switzerland.

Halogenation of amphetamines and methcathinones has become a common method to obtain novel psychoactive substances (NPS) also called "legal highs". The -halogenated derivatives of amphetamine and methcathinone are available over the internet and have entered the illicit drug market but studies on their potential neurotoxic effects are rare. The primary aim of this study was to explore the neurotoxicity of amphetamine, methcathinone and their -halogenated derivatives 4-fluoroamphetamine (4-FA), 4-chloroamphetamine (PCA), 4-fluoromethcathinone (4-FMC), and 4-chloromethcathinone (4-CMC) in undifferentiated and differentiated SH-SY5Y cells. Read More

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http://dx.doi.org/10.3390/ijms21082841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215714PMC

Identification of a novel PAK1 inhibitor to treat pancreatic cancer.

Acta Pharm Sin B 2020 Apr 16;10(4):603-614. Epub 2019 Dec 16.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.

Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate. The family of P21-activated kinases (PAKs) appears to modulate many signaling pathways that contribute to pancreatic carcinogenesis. In this work, we demonstrated that PAK1 is a critical regulator in pancreatic cancer cell growth. Read More

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http://dx.doi.org/10.1016/j.apsb.2019.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161699PMC

ITRAQ-based proteomics reveals the potential mechanism of fluoride-induced myocardial contraction function damage.

Ecotoxicol Environ Saf 2020 Jul 17;197:110605. Epub 2020 Apr 17.

School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, 030001, China. Electronic address:

Fluorosis is a worldwide public health problem, and its adverse effects on the heart have been confirmed by many studies. Abnormal myocardial contractions are often associated with impairment of cardiac function as a cause or consequence. We designed two-part experiments to search for biomarkers and clarify the underlying molecular mechanism of fluoride on myocardial contraction. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110605DOI Listing

Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways.

Environ Sci Pollut Res Int 2020 Apr 17. Epub 2020 Apr 17.

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Fluoride (F) and cadmium (Cd) are two common water pollutants. There is low information about their co-exposure in low doses. So, in this study, we evaluated the combination effects of non-toxic doses of F and Cd and the possible mechanism of their combined interaction. Read More

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http://dx.doi.org/10.1007/s11356-020-08791-4DOI Listing
April 2020
2.828 Impact Factor

Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice.

Biol Reprod 2020 Apr 18. Epub 2020 Apr 18.

School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

Inhibition of the sperm transport process in the female reproductive tract could lead to infertility. We previously showed that a pan-serine protease inhibitor, 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF), blocked semen liquefaction in vivo and resulted in a drastic decrease in the number of sperm in the oviduct of female mice. In this study, we used a mouse model to test the efficacy of AEBSF as a reversible contraceptive, a sperm motility inhibitor, and a spermicide. Read More

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http://dx.doi.org/10.1093/biolre/ioaa049DOI Listing

The use of a single ammonium acidic salt towards simple green co-precipitation synthesis for Mn-activated fluorides.

Dalton Trans 2020 May 16;49(18):5823-5831. Epub 2020 Apr 16.

School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China.

Herein, a simple green co-precipitation route for Mn-activated fluorides has been realized via individually using the aqueous acidic salt NHHF as a solvent. The systematic explorations of ionization, erosion, solvent concentration, solvency on reactants, and reaction with an extra weak acid disclosed that the near-saturated aqueous NHHF, ionizing into abundant HF, H, and F ions, exhibited large dissolving capacity and good stabilization on Mn without obvious toxicity. The green synthesized example of CsGeF:Mn emitted a typical narrow band red light at 633 nm with normal optimal doping at ∼8 at%. Read More

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http://dx.doi.org/10.1039/d0dt00986eDOI Listing

Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway.

Environ Toxicol 2020 Apr 15. Epub 2020 Apr 15.

Clinical Research Center, The First Affliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Excessive fluoride exposure contributes to neurotoxic effects. Emodin exhibits antioxidative functions in the central nervous system (CNS); however, its neuroprotective mechanism against fluoride remains to be elucidated. Our aim was to explore the neuroprotective efficacy and the possible mechanisms of emodin. Read More

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http://dx.doi.org/10.1002/tox.22928DOI Listing

Assessment of phytotoxicity of leachates from landfilled waste and dust from foundry.

Authors:
Marta Bożym

Ecotoxicology 2020 May 14;29(4):429-443. Epub 2020 Apr 14.

Opole University of Technology, Prószkowska 76 Street, Opole, 45-758, Poland.

The study assesses the contamination, classification and phytotoxicity of foundry waste. The presented results are a part of the research on the agrotechnical use of foundry waste. Landfilled foundry waste (LFW) and dust samples were taken from one of the Polish foundries. Read More

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http://dx.doi.org/10.1007/s10646-020-02197-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182548PMC

Physicochemical and Toxicological Assay of Leachate from Malt Spent Rootlets Biochar.

Bull Environ Contam Toxicol 2020 May 31;104(5):634-641. Epub 2020 Mar 31.

Environmental Engineering Laboratory, Department of Civil Engineering, University of Patras, 26504, Patras, Greece.

The aim of this study was to characterize the leachate derived from biochar produced from malt spent rootlets (MSR) and to evaluate the required washing level in order to provide water free from inorganic substances. MSR biochar was placed in a column and subjected to six serial washes with distilled water, and the leachate was analysed for main anions and heavy metals. The 1st wash aliquot contained increased levels of mainly phosphates (980 mg/L) and chlorides (760 mg/L), and lower levels of nitrates, sulfates, fluoride and bromide, which were decreased over washes. Read More

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http://dx.doi.org/10.1007/s00128-020-02839-4DOI Listing
May 2020
1.255 Impact Factor

Fluoride in Drinking Water and Skeletal Fluorosis: a Review of the Global Impact.

Curr Environ Health Rep 2020 Jun;7(2):140-146

National Institute of Pharmaceutical Education and Research, Near CRPF Base Camp, Bijnor-Sisendi Road, Post Office Mati, Lucknow, U.P., 226 002, India.

When safe and adequate exposure of an essential trace element is exceeded it becomes potentially toxic. Fluoride is one classic example of such a double edged sword which both plays a fundamental role in the normal growth and development of the body for example the consumption of levels between 0.5-1. Read More

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http://dx.doi.org/10.1007/s40572-020-00270-9DOI Listing

Principles of fluoride toxicity and the cellular response: a review.

Arch Toxicol 2020 Apr 9;94(4):1051-1069. Epub 2020 Mar 9.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.

Fluoride is ubiquitously present throughout the world. It is released from minerals, magmatic gas, and industrial processing, and travels in the atmosphere and water. Exposure to low concentrations of fluoride increases overall oral health. Read More

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http://dx.doi.org/10.1007/s00204-020-02687-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230026PMC

Protections against toxicity in the brains of rat with chronic fluorosis and primary neurons exposed to fluoride by resveratrol involves nicotinic acetylcholine receptors.

J Trace Elem Med Biol 2020 Jul 27;60:126475. Epub 2020 Feb 27.

Departments of Pathology at Guizhou Medical University and the Affiliated Hospital of Guizhou Medical University, PR China; Key Laboratory of Endemic and Ethnic Diseases, (Guizhou Medical University) of the Ministry of Education, PR China; Provincial Key Laboratory of Medical Molecular Biology, Guiyang, 550004, Guizhou, PR China. Electronic address:

Protection of Resveratrol (RSV) against the neurotoxicity induced by high level of fluoride was investigated. Sprague-Dawley (SD) rats and their offspring, as well as cultures of primary neurons were divided randomly into four groups: untreated (control); treated with 50 mg RSV/kg/ (once daily by gavage) or (20 M in the cultured medium); exposed to 50 ppm F in drinking water or 4 mmol/l in the cultured medium; and exposed to fluoride then RSV as above. The adult rats were treated for 7 months and the offspring sacrificed at 28 days of age; the cultured neurons for 48 h. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126475DOI Listing

Chemical Speciation of Aluminum in Wine by LC-ICP-MS.

Molecules 2020 Feb 27;25(5). Epub 2020 Feb 27.

Department of Analytical and Environmental Chemistry, Adam Mickiewicz University Poznań, Faculty of Chemistry, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.

Aluminum is very common in the natural environment and in everyday human life. We are living in the "aluminum age." Its average daily intake should not exceed a few mg/day. Read More

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http://dx.doi.org/10.3390/molecules25051069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179188PMC
February 2020

Alterations in cecal microbiota and intestinal barrier function of laying hens fed on fluoride supplemented diets.

Ecotoxicol Environ Saf 2020 Apr 27;193:110372. Epub 2020 Feb 27.

Key Laboratory of Animal Nutrition and Feed Science in East China, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China. Electronic address:

The objective of this study was to investigate the effects of fluorine at levels of 31, 431, 1237 mg/kg feed on cecum microbe, short-chain fatty acids (SCFAs) and intestinal barrier function of laying hens. The results showed that the intestinal morphology and ultrastructure were damaged by dietary high F intake. The mRNA expression levels of zonula occludens-1, zonula occludens-2, claudin-1, and claudin-4 were decreased in jejunum and ileum. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110372DOI Listing

Innovative Poly (Vinylidene Fluoride) (PVDF) Electrospun Nanofiber Membrane Preparation Using DMSO as a Low Toxicity Solvent.

Membranes (Basel) 2020 Feb 26;10(3). Epub 2020 Feb 26.

Institute on Membrane Technology (ITM-CNR), Via Pietro Bucci, Cubo 17/C, 87036 Rende (CS), Italy.

Electrospinning is an emerging technique for the preparation of electrospun fiber membranes (ENMs), and a very promising one on the basis of the high-yield and the scalability of the process according to a process intensification strategy. Most of the research reported in the literature has been focused on the preparation of poly (vinylidene fluoride) (PVDF) ENMs by using N,N- dimethylformamide (DMF) as a solvent, which is considered a mutagenic and cancerogenic substance. Hence, the possibility of using alternative solvents represents an interesting approach to investigate. Read More

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http://dx.doi.org/10.3390/membranes10030036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142737PMC
February 2020

Thermal behaviors of fluorine during (co-)incinerations of spent potlining and red mud: Transformation, retention, leaching and thermodynamic modeling analyses.

Chemosphere 2020 Jun 14;249:126204. Epub 2020 Feb 14.

School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, 510006, China.

Spent potlining (SPL) as a hazardous solid waste has a high content of inorganic fluorine. This study aimed at characterizing its transformation, retention and leaching behaviors with(out) the addition of red mud (RM) during the SPL incineration. The RM addition positively affected its retention and leaching rates. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126204DOI Listing
June 2020
3.340 Impact Factor

Induced Hydrophilicity and In Vitro Preliminary Osteoblast Response of Polyvinylidene Fluoride (PVDF) Coatings Obtained via MAPLE Deposition and Subsequent Thermal Treatment.

Molecules 2020 Jan 29;25(3). Epub 2020 Jan 29.

INFLPR-National Institute for Laser, Plasma and Radiation Physics, Bvd. Atomistilor, Nr. 409, Magurele (Ilfov), 077125 Bucharest, Romania.

Recent advancements in biomedicine have focused on designing novel and stable interfaces that can drive a specific cellular response toward the requirements of medical devices or implants. Among these, in recent years, electroactive polymers (i.e. Read More

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http://dx.doi.org/10.3390/molecules25030582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036970PMC
January 2020

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells.

Biol Trace Elem Res 2020 Jan 25. Epub 2020 Jan 25.

Henan Key Laboratory of Environmental and Animal Product Safety, Henan University of Science and Technology, Kaiyuan Avenue 263, Luoyang, 471003, Henan, People's Republic of China.

The role of pro-inflammatory cytokines in the toxicity of fluoride to tumor cells was investigated by culturing Hepa1-6 cells in medium containing gradient concentrations of fluoride (0, 0.5, 1, 1.5, 2, 3, 4, and 5 mmol/L). Read More

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http://dx.doi.org/10.1007/s12011-019-01967-1DOI Listing
January 2020

Synergistically Chemical and Thermal Coupling between Graphene Oxide and Graphene Fluoride for Enhancing Aluminum Combustion.

ACS Appl Mater Interfaces 2020 Feb 28;12(6):7451-7458. Epub 2020 Jan 28.

Department of Mechanical Engineering , Stanford University , Stanford , California 94305 , United States.

Metal combustion reaction is highly exothermic and is used in energetic applications, such as propulsion, pyrotechnics, powering micro- and nano-devices, and nanomaterials synthesis. Aluminum (Al) is attracting great interest in those applications because of its high energy density, earth abundance, and low toxicity. Nevertheless, Al combustion is hard to initiate and progresses slowly and incompletely. Read More

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http://dx.doi.org/10.1021/acsami.9b20397DOI Listing
February 2020

In vivo biocompatibility study of degradable homo- versus multiblock copolymers and their (micro)structure compared to an established biomaterial.

Clin Hemorheol Microcirc 2020 Jan 4. Epub 2020 Jan 4.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany.

Copolyetheresterurethane (PDC) is a biodegradable, shape-memory biomaterial, which has been shown to be of low toxicity and pro-angiogenic in vitro. In the present study we examined the in vivo compatibility of PDC as a compression molded film and as electrospun scaffolds and its well established constituent, the homopolymer poly(p-dioxanone) (PPDO), which were compared with the clinically used poly[(vinylidene fluoride)-co-hexafluoropropene] (PVDF) as reference material. The materials were implanted in the subcutaneous tissue of mice and the host responses were analyzed histologically 7 and 28 days after implantation. Read More

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http://dx.doi.org/10.3233/CH-190748DOI Listing
January 2020

Histone acetyltransferase promotes fluoride toxicity in LS8 cells.

Chemosphere 2020 May 3;247:125825. Epub 2020 Jan 3.

Department of Oral Biology and Diagnostic Sciences, The Dental College of Georgia, Augusta University, Augusta, GA, 30912, USA. Electronic address:

Previously we demonstrated that fluoride increased acetylated-p53 (Ac-p53) in LS8 cells that are derived from mouse enamel organ epithelia and in rodent ameloblasts. However, how p53 is acetylated by fluoride and how the p53 upstream molecular pathway responds to fluoride is not well characterized. Here we demonstrate that fluoride activates histone acetyltransferases (HATs) including CBP, p300, PCAF and Tip60 to acetylate p53. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.125825DOI Listing

Deciphering the molecular mechanism behind stimulated co-uptake of arsenic and fluoride from soil, associated toxicity, defence and glyoxalase machineries in arsenic-tolerant rice.

J Hazard Mater 2020 05 25;390:121978. Epub 2019 Dec 25.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, 700016, West Bengal, India. Electronic address:

The current study elucidates the uncharacterized biohazard associated with rice growth in arsenic and fluoride co-contaminated sites. Analysis of the arsenic-tolerant rice cultivar, Muktashri (known to restrict arsenic uptake) revealed that fluoride largely stimulated arsenic bioaccumulation in the stressed tissues and vice versa. Gene expression studies revealed that high arsenic uptake was facilitated by the fluoride-dependent up regulation of phosphate transporter2 (PT2), PT8 and low silicon rice1 (Lsi1), and elevated fluoride accumulation was stimulated by the arsenic-mediated induction of chloride channels (CLCs). Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.121978DOI Listing

Fluoride exposure alters the ultra-structure of sperm flagellum via reducing key protein expressions in testis.

Chemosphere 2020 May 30;246:125772. Epub 2019 Dec 30.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, China. Electronic address:

Excessive fluoride (F) ingestion via drinking water interfered with spermatogenesis and lowered sperm quality of human and animals. However, it is still unclear why the effects of fluoride on sperm quality focus on mostly sperm motility rather than sperm count. The objective of this study is to investigate the potential relationship between alteration in the structure and function of sperm flagellum and fluoride exposure in the environment. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125772DOI Listing

Polymer-Based Membranes for Oily Wastewater Remediation.

Polymers (Basel) 2019 Dec 26;12(1). Epub 2019 Dec 26.

Centre/Departament of Physics, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

The compounds found in industrial wastewater typically show high toxicity, and in this way, they have become a primary environmental concern. Several techniques have been applied in industrial effluent remediation. In spite of the efforts, these techniques are yet to be ineffective to treat oily wastewater before it can be discharged safely to the environment. Read More

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http://dx.doi.org/10.3390/polym12010042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023582PMC
December 2019

Fluoride-induced rectal barrier damage and microflora disorder in mice.

Environ Sci Pollut Res Int 2020 Mar 29;27(7):7596-7607. Epub 2019 Dec 29.

Henan Key Laboratory of Environmental and Animal Product Safety, Henan University of Science and Technology, Kaiyuan Avenue 263, Luoyang, 471000, Henan, People's Republic of China.

Intestinal microflora plays a key role in maintaining the homeostasis between immune and host health. Here, we reported the fluoride-induced changes of rectal structure and microflora in mice. The morphology of rectal tissue was observed by hematoxylin and eosin staining. Read More

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http://dx.doi.org/10.1007/s11356-019-07201-8DOI Listing

Environmental exposure of arsenic and fluoride and their combined toxicity: A recent update.

J Appl Toxicol 2020 May 22;40(5):552-566. Epub 2019 Dec 22.

Department of Zoology, Visva-Bharati University, Santiniketan, West Bengal, India.

Environmental exposure to arsenic (As) and fluoride (F) in the recent year has been increased because of excessive use of naturally contaminated ground water. Surface water is also regularly contaminated with these elements in various industrial areas. Arsenicosis and fluorosis upon individual exposure of As and F are reported in many studies. Read More

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http://dx.doi.org/10.1002/jat.3931DOI Listing

Fluorosis and cognitive development among children (6-14 years of age) in the endemic areas of the world: a review and critical analysis.

Environ Sci Pollut Res Int 2020 Jan 23;27(3):2566-2579. Epub 2019 Dec 23.

Environmental Biology, Ecotoxicology, Environmental Health Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

The fluoride contamination in water is still a live discussion among the scientific community, because of its beneficial and injurious health effects inflicted on the human population. The magnitude of groundwater fluoride contamination is aggravated by increasing anthropogenic activities. Groundwater is supposedly the main source through which people are highly exposed to fluoride, compared with other sources of exposure. Read More

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http://dx.doi.org/10.1007/s11356-019-06938-6DOI Listing
January 2020
2.828 Impact Factor

Developmental fluoride neurotoxicity: an updated review.

Environ Health 2019 12 19;18(1):110. Epub 2019 Dec 19.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Background: After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health. However, this practice results in elevated fluoride intake and has become controversial for two reasons. First, topical fluoride application in the oral cavity appears to be a more direct and appropriate means of preventing caries. Read More

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http://dx.doi.org/10.1186/s12940-019-0551-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923889PMC
December 2019

Intestinal fungal dysbiosis in mice induced by fluoride.

Chemosphere 2020 Apr 10;245:125617. Epub 2019 Dec 10.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, China. Electronic address:

To explore the effects of fluoride on intestinal fungi in mice, the internal transcriptional spacer (ITS) region in colon feces of mice exposed to 100 mg sodium fluoride (NaF)/L of distilled water for 60 days were sequenced. Results showed that, there were 305 operational taxonomic units (OTUs) unique to the control group, 154 OTUs to the fluoride group, and 295 OTUs were detected in both groups. There was no significant difference in relative species abundance between the two groups at phylum levels. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125617DOI Listing

Seed priming with calcium compounds abrogate fluoride-induced oxidative stress by upregulating defence pathways in an indica rice variety.

Protoplasma 2020 May 18;257(3):767-782. Epub 2019 Dec 18.

Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, West Bengal, 700016, India.

The aim of this manuscript was to investigate the role of calcium compounds, viz., Ca(OH), Ca(NO), and CaCl (each used at 0.3 mM and 0. Read More

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http://dx.doi.org/10.1007/s00709-019-01460-5DOI Listing

Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring.

Arch Toxicol 2020 Mar 16;94(3):749-760. Epub 2019 Dec 16.

School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Exposure to fluoride (F) or arsenite (As) through contaminated drinking water has been associated with chronic nephrotoxicity in humans. Autophagy is a regulated mechanism ubiquitous for the body in a toxic environment with F and As, but the underlying mechanisms of autophagy in the single or combined nephrotoxicity of F and As are unclear. In the present study, we established a rat model of prenatal and postnatal exposure to F and As with the aim of investigating the mechanism underlying nephrotoxicity of these pollutants in offspring. Read More

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http://dx.doi.org/10.1007/s00204-019-02651-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085982PMC

AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride.

Chemosphere 2020 Apr 27;244:125495. Epub 2019 Nov 27.

Zhengzhou Key Laboratory of Animal Nutrition Metabolic and Poisoning Diseases, College of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou, Henan, 450000, People's Republic of China. Electronic address:

Dysregulated activation of inflammation plays an important role in the development and progression of neuronal damage, and limiting the production of reactive oxygen species (ROS) can suppress the inflammatory signals. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensing transcription factor that drives an adaptive cellular defense in response to oxidative stress. However, the implications of Nrf2 in sodium fluoride (NaF)-stimulated microglia and the underlying mechanisms remain obscure. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125495DOI Listing
April 2020
3.340 Impact Factor

Selective synthesis of spirobiindanes, alkenyl chlorides, and monofluoroalkenes from unactivated gem-difluoroalkanes controlled by aluminum-based Lewis acids.

Sci Rep 2019 12 13;9(1):19113. Epub 2019 Dec 13.

Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, 466-5888, Japan.

The highly selective synthesis of spirobiindanes, alkenyl chlorides, and monofluoroalkenes via the cleavage of inert C(sp)-F bonds in unactivated gem-difluoroalkanes using readily available and inexpensive aluminum-based Lewis acids of low toxicity is reported. The selectivity of this reaction can be controlled by modifying the substituents on the central aluminum atom of the promoter. An intramolecular cascade Friedel-Crafts alkylation of unactivated gem-difluorocarbons can be achieved using a stoichiometric amount of AlCl. Read More

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http://dx.doi.org/10.1038/s41598-019-55206-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911048PMC
December 2019

A Comparative Analysis of Fluoride-Contaminated Groundwater and Sodium Fluoride-Induced Reproductive Toxicity and Its Reversibility in Male Rats.

Biol Trace Elem Res 2019 Dec 13. Epub 2019 Dec 13.

Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, 570006, India.

The present study was undertaken to investigate the toxic effect of sodium fluoride (NaF)- and fluoride (F)-contaminated groundwater on male reproduction and it's reversibility in male rats. Adult male rats were orally treated with different concentrations of NaF- (1 mg, 5 mg, and 10 mg/kg/bw/rat) and F-contaminated groundwater for 52 days and after the confirmation of F-induced damage, the rats were allowed for recovery studies for 52 days. Exposure of NaF- and F-contaminated groundwater caused significant decline in total sperm count, sperm motility, serum concentration of testosterone, activities of testicular 3β-HSDH, counts of type A spermatogonia, preleptotene spermatocytes, midpachytene spermatocytes, elongated spermatids and round spermatids, activities of testicular and spermatozoa SOD and CAT, and increase in sperm abnormality and concentration of MDA of testis and spermatozoa compared to controls. Read More

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http://dx.doi.org/10.1007/s12011-019-01994-yDOI Listing
December 2019

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.

J Neuroinflammation 2019 Dec 3;16(1):252. Epub 2019 Dec 3.

Turku PET Centre, University of Turku, Turku, Finland.

Background: Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based therapeutic and diagnostic agents. FR-β expression in central nervous system inflammation remains relatively unexplored. Therefore, we used focally induced acute and chronic phases of experimental autoimmune encephalomyelitis (EAE) to study patterns of FR-β expression and evaluated its potential as an in vivo imaging target. Read More

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http://dx.doi.org/10.1186/s12974-019-1612-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892159PMC
December 2019

Estimation of hazardous materials in water and their toxicity levels in Mahayel Aseer, Kingdom of Saudi Arabia (KSA).

Environ Monit Assess 2019 Nov 29;191(12):779. Epub 2019 Nov 29.

Physics Dept., King Khaled Univ., Tohama Branch, Abha, Saudi Arabia.

This work aims to evaluate the different water sources available in Mahayel Aseer, KSA, chemically, toxicology and microbiologically. Several water samples, such as tap water, differentially desalinated water and bottled water, were analysed. Moreover, different metal ions and anions, including sodium, potassium, calcium, lead, cadmium, manganese, bicarbonate, fluoride, chloride, sulphate, nitrate and nitrite, were evaluated and assessed for human health. Read More

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http://dx.doi.org/10.1007/s10661-019-7820-6DOI Listing
November 2019

Rapid photochemical decomposition of perfluorooctanoic acid mediated by a comprehensive effect of nitrogen dioxide radicals and Fe/Fe redox cycle.

J Hazard Mater 2020 04 20;388:121730. Epub 2019 Nov 20.

Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China. Electronic address:

Developing efficient methods to degrade perfluorochemicals (PFCs), an emerging class of highly recalcitrant contaminants, are urgently needed in recent years, due to their persistence, high toxicity, and resistance to most regular treatment procedures. Here, a UV-photolysis system is reported for efficient mineralization of perfluorooctanoic acid (PFOA) via irradiation of ferric nitrate aqueous solution, where in-situ generating •NO and the effective Fe/Fe redox cycle synergistically play great roles on rapidly mediating the mineralization of PFOA. A fast PFOA removal kinetics with first-order kinetic constants of 2. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.121730DOI Listing

Sodium fluoride exposure triggered the formation of neutrophil extracellular traps.

Environ Pollut 2020 Feb 15;257:113583. Epub 2019 Nov 15.

College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, People's Republic of China. Electronic address:

In recent years, numerous studies paid more attention to the molecular mechanisms associated with fluoride toxicity. However, the detailed mechanisms of fluoride immunotoxicity in bovine neutrophils remain unclear. Neutrophil extracellular traps (NETs) is a novel immune mechanism of neutrophils. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113583DOI Listing
February 2020

Geochemical modeling, source apportionment, health risk exposure and control of higher fluoride in groundwater of sub-district Dargai, Pakistan.

Chemosphere 2020 Mar 19;243:125409. Epub 2019 Nov 19.

Hydrogeochemistry Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, PO 45320, Pakistan.

The present study examined the hydrogeochemical profile of higher fluoride (F) in groundwater of mixed industrial and mining areas of Dargai, northern Pakistan. Groundwater samples (n = 75) were collected from three hydrogeochemical environments. The mean concentrations of pH, EC, TDS, Depth and Temperature were (7. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125409DOI Listing
March 2020
4 Reads

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity in .

Exp Biol Med (Maywood) 2019 12 25;244(18):1688-1694. Epub 2019 Nov 25.

Department of Biochemistry, Molecular Drug Metabolism and Toxicology Unit, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan 20028, Nigeria.

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http://dx.doi.org/10.1177/1535370219890334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963375PMC
December 2019

Spermidine application reduces fluoride uptake and ameliorates physiological injuries in a susceptible rice cultivar by activating diverse regulators of the defense machinery.

Environ Sci Pollut Res Int 2019 Dec 16;26(36):36598-36614. Epub 2019 Nov 16.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, West Bengal, 700016, India.

The manuscript illustrates the ameliorative effects of exogenously applied higher polyamine (PA), spermidine (Spd) in the susceptible indica rice cultivar IR-64 subjected to prolonged fluoride stress. The Spd treatment drastically reduced fluoride bioaccumulation by restricting entry of the anions through chloride channels and enabled better maintenance of the proton gradient via accumulation of P-H/ATPase, thereby improving the root and shoot lengths, fresh and dry weights, RWC, chlorophyll content and activities of pyruvate dehydrogenase (PyrDH), α-amylase, and nitrate reductase (NR) in the Spd-treated, stressed plants. Expression of RuBisCo, PyrDH, α-amylase, and NR was stimulated. Read More

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http://dx.doi.org/10.1007/s11356-019-06711-9DOI Listing
December 2019
3 Reads

Stereotactic ablative body radiotherapy (SABR) for bone only oligometastatic breast cancer: A prospective clinical trial.

Breast 2020 Feb 6;49:55-62. Epub 2019 Nov 6.

Peter MacCallum Cancer Centre, Australia.

Background: Stereotactic ablative body radiotherapy (SABR) is an emerging noninvasive approach for the treatment of oligometastases. Limited prospective evidence is available in breast cancer.

Objectives: To determine the safety and feasibility of single fraction SABR for patients with bone only oligometastatic breast cancer. Read More

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http://dx.doi.org/10.1016/j.breast.2019.10.016DOI Listing
February 2020

Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

Environ Toxicol Pharmacol 2020 Jan 17;73:103275. Epub 2019 Oct 17.

Department of Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China. Electronic address:

Skeletal fluorosis causes growth plate impairment and growth retardation during bone development. Longitudinal bone development is accomplished by endochondral ossification in growth plate. However, the mechanism of fluoride impairs growth plate is unclear. Read More

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http://dx.doi.org/10.1016/j.etap.2019.103275DOI Listing
January 2020

Clofibrate, a PPAR-α agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba-1/anti-calbindin signaling pathways.

Environ Toxicol 2020 Feb 11;35(2):242-253. Epub 2019 Nov 11.

Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Texas Southern University, Houston, Texas.

Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water, toothpaste, and mouth rinses to prevent tooth decay. Epidemiological findings have demonstrated that exposure to fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, and motor disorders. Read More

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http://dx.doi.org/10.1002/tox.22861DOI Listing
February 2020
3.197 Impact Factor

Fluoride Induces Autoimmune Orchitis Involved with Enhanced IL-17A Secretion in Mice Testis.

J Agric Food Chem 2019 Dec 18;67(48):13333-13343. Epub 2019 Nov 18.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine , Shanxi Agricultural University , Taigu , Shanxi 030801 , China.

Fluoride (F) widely exists in the water and food. Recent studies reported that F induced testicular toxicity via inflammation reaction. This study was aimed to explore the mechanism of F-induced inflammation in testis. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b05789DOI Listing
December 2019
2.912 Impact Factor