3,146 results match your criteria Toxicity Fluoride


Characterization of False or Misleading Fluoride Content on Instagram: Infodemiology Study.

J Med Internet Res 2022 May 19;24(5):e37519. Epub 2022 May 19.

Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.

Background: Online false or misleading oral health-related content has been propagated on social media to deceive people against fluoride's economic and health benefits to prevent dental caries.

Objective: The aim of this study was to characterize the false or misleading fluoride-related content on Instagram.

Methods: A total of 3863 posts ranked by users' total interaction and published between August 2016 and August 2021 were retrieved by CrowdTangle, of which 641 were screened to obtain 500 final posts. Read More

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An Study to Compare the Release of Fluoride from Glass Ionomer Cement (Fuji IX) and Zirconomer.

Int J Clin Pediatr Dent 2022 Jan-Feb;15(1):35-37

Department of pedodontics and preventive dentistry, Rungta college of Dental Science and Research Center, Bhilai, Chhattisgarh, India.

Mercury toxicity from amalgam dental fillings and their potential for creating problems in the environment and for human health have prompted the development of new restorative materials. The leading alternatives among these are glass ionomer cements. According to current understanding, restorative materials that slowly release fluoride exert a local cariostatic effect. Read More

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Fluoride Induced Neurobehavioral Impairments in Experimental Animals: a Brief Review.

Biol Trace Elem Res 2022 Apr 30. Epub 2022 Apr 30.

Bharathiar University, Coimbatore, Tamilnadu, India.

Fluoride is one of the major toxicants in the environment and is often found in drinking water at higher concentrations. Living organisms including humans exposed to high fluoride levels are found to develop mild-to-severe detrimental pathological conditions called fluorosis. Fluoride can cross the hematoencephalic barrier and settle in various brain regions. Read More

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Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children.

Pediatr Dent 2022 Mar;44(2):114-121

University of Washington, Seattle, Wash., USA.

Purpose: The purpose of this study was to measure serum levels and characterize the pharmacokinetics of silver and fluoride in healthy children receiving silver diamine fluoride (SDF) treatment for dental caries lesions.

Methods: Children (three to 13 years old with at least one caries lesion) were recruited at the University of California, San Francisco Pediatric Dental Clinic from August 2019 through March 2020. Blood was obtained at one randomly selected timepoint up to 168 hours after SDF application. Read More

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Preliminary screening of microplastic contamination in different marine fish species of Taif market, Saudi Arabia.

Open Life Sci 2022 6;17(1):333-343. Epub 2022 Apr 6.

Research and Development Sector, EGYVAC, VACSERA, Giza 12311, Egypt.

Microplastics (MPs), as a physical anthropogenic contaminant, represent a serious, human health concern due to their toxicity and ability to act as vectors for other pollutants and pathogens. This study aimed to screen for MP contamination in marine fish in Taif market, Saudi Arabia. A total of 22 fish species were used according to their different marine habitats and feedings. Read More

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Exposure to Fluoride From in Utero to Puberty Alters Gonadal Structure and Steroid Hormone Expression in Offspring Rats.

Biol Trace Elem Res 2022 Apr 21. Epub 2022 Apr 21.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.

The reproductive toxicity of fluoride has been proven by a large number of studies. While the underlying mechanism of reproductive toxicity during pregnancy is still unclear. Hence, in this study, we investigated the effects of fluoride exposure on ovarian and testicular steroid hormone synthesis in young and adult rat offspring. Read More

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Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.

Ecotoxicol Environ Saf 2022 May 11;236:113500. Epub 2022 Apr 11.

Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China; NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases (First Affiliated Hospital, School of Medicine, Shihezi University), People's Republic of China. Electronic address:

Fluoride is capable of inducing developmental neurotoxicity, yet its mechanisms remain elusive. We aimed to explore the possible role and mechanism of autophagic flux blockage caused by abnormal lysosomal pH in fluoride-induced developmental neurotoxicity, focusing on the role of V-ATPase in regulating the neuronal lysosomal pH. Using Sprague-Dawley rats exposed to sodium fluoride (NaF) from gestation through delivery until the neonatal offspring reached six months of age as an in vivo model. Read More

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Poly(4-Styrenesulfonic Acid--maleic Anhydride)-Coated NaGdF:Yb,Tb,Nd Nanoparticles with Luminescence and Magnetic Properties for Imaging of Pancreatic Islets and β-Cells.

ACS Appl Mater Interfaces 2022 Apr 13;14(16):18233-18247. Epub 2022 Apr 13.

Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovského nám. 2, Prague 6 162 06, Czech Republic.

Novel Yb,Tb,Nd-doped GdF and NaGdF nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesulfonic acid--maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb, Tb, and Nd ions in the NaGdF host nanoparticles induced luminescence under ultraviolet and near-infrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). Read More

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Forchlorfenuron and Novel Analogs Cause Cytotoxic Effects in Untreated and Cisplatin-Resistant Malignant Mesothelioma-Derived Cells.

Int J Mol Sci 2022 Apr 2;23(7). Epub 2022 Apr 2.

Anatomy, Section of Medicine, Faculty of Science and Medicine, University of Fribourg, Route Albert-Gockel 1, CH-1700 Fribourg, Switzerland.

Malignant mesothelioma (MM) is a currently incurable, aggressive cancer derived from mesothelial cells, most often resulting from asbestos exposure. The current first-line treatment in unresectable MM is cisplatin/pemetrexed, which shows very little long-term effectiveness, necessitating research for novel therapeutic interventions. The existing chemotherapies often act on the cytoskeleton, including actin filaments and microtubules, but recent advances indicate the 'fourth' form consisting of the family of septins, representing a novel target. Read More

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Fluoride toxicity in cropping systems: Mitigation, adaptation strategies and related mechanisms. A review.

Sci Total Environ 2022 Apr 9;833:155129. Epub 2022 Apr 9.

Department of Soil Science, University of Eldoret, P. O. BOX 1125-30100 Eldoret, Kenya.

Environmental fluoride (F) contamination, mainly due to natural geogenic processes, and in spot cases also of anthropogenic origin, is a widespread global issue, which has been recognized to affect all living organisms. From the contaminated soil and water, F is absorbed by plants which can manifest symptoms of abiotic stress including oxidative stress and interference with essential physiological and biochemical processes involved in seed germination and plant growth and development. Depending on the diet of the population living in the high F-polluted areas, F-contaminated crops can be key contributors to excessive F intake along food chains which can lead to human and animal health issues. Read More

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A smartphone integrated ratiometric fluorescent sensor for point-of-care testing of fluoride ions.

Anal Bioanal Chem 2022 May 9;414(13):3999-4009. Epub 2022 Apr 9.

State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China.

In view of the high toxicity and widespread availability, it is of great importance to develop accurate, sensitive, and convenient assays for fluoride ion (F) detection. Herein, a ratiometric fluorescent system is established for point-of-care testing (POCT) of F with a smartphone as analyzer. The sensing system of calcein-QDs-Eu contains two fluorescent probes of calcein (green emission) and ZnCdSe/ZnS QDs (red emission). Read More

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Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity - A review.

Environ Pollut 2022 Jul 1;304:119241. Epub 2022 Apr 1.

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Fluoride is an important trace element in the living body. A suitable amount of fluoride has a beneficial effect on the body, but disproportionate fluoride entering the body will affect various organs and systems, especially the liver, kidneys, nervous system, endocrine system, reproductive system, bone, and intestinal system. In recent years, with the rapid development of agriculture and industry, fluoride pollution has become one of the important factors of environmental pollution, and fluoride pollution in any form is becoming a serious problem. Read More

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ESPEN micronutrient guideline.

Clin Nutr 2022 Feb 26. Epub 2022 Feb 26.

Departamento de Medicina, Universidad Complutense de Madrid, Nutrition Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address:

Background: Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. Recent research has shown the importance of MNs in common pathologies, with significant deficiencies impacting the outcome.

Objective: This guideline aims to provide information for daily clinical nutrition practice regarding assessment of MN status, monitoring, and prescription. Read More

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February 2022

Skeletal Fluorosis: A Case of Inhalant Abuse Leading to a Diagnosis of Colon Cancer.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221084919

Medical College of Wisconsin, Milwaukee, USA.

Skeletal fluorosis is a long-term bone disease that develops when prolonged fluoride toxicity leads to osteosclerosis and bone deformities that result in crippling pain and debility. The disease is endemic to many countries due to environmental or industrial exposures. However, rare cases in the United States have been reported from various causes including heavy toothpaste ingestion, excessive tea consumption, voriconazole use, and inhalant abuse. Read More

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Harnessing the Antibacterial Properties of Fluoridated Chitosan Polymers against Oral Biofilms.

Pharmaceutics 2022 Feb 23;14(3). Epub 2022 Feb 23.

School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.

Dental caries are a worldwide endemic chronic disease affecting people of all ages. Due to the limitations of daily used oral hygiene products, there is an unmet need for new, effective, safe, and economic oral products. We have recently demonstrated that -(2(2,6-diaminohexanamide)-chitosan (CS3H Lys) has enhanced antibacterial properties against the main cariogenic bacterium, and here we investigated the effect of fluoridation of this polymer (CS3H Lys F) on its antibacterial properties and the ability to protect teeth from acid demineralization. Read More

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February 2022

Fluorescence Sensors Based on Hydroxycarbazole for the Determination of Neurodegeneration-Related Halide Anions.

Biosensors (Basel) 2022 Mar 14;12(3). Epub 2022 Mar 14.

Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

The environmental presence of anions of natural origin or anthropogenic origin is gradually increasing. As a tool to tackle this problem, carbazole derivatives are an attractive gateway to the development of luminescent chemosensors. Considering the different mechanisms proposed for anion recognition, the fluorescence properties and anion-binding response of several newly synthesised carbazole derivatives were studied. Read More

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Quinoline based thiosemicarbazones as colorimetric chemosensors for fluoride and cyanide ions and DFT studies.

Sci Rep 2022 03 23;12(1):4927. Epub 2022 Mar 23.

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.

High toxicity and extensive accessibility of fluoride and cyanide ions in diverse environmental media encouraged attention for scheming well-organized probes for their detection. Keeping in mind we have designed and synthesized thiosemicarbazone-based chemosensors RB-1, RB-2 and RB-3 for the detection of fluoride and cyanide ions. The structural elucidation of the synthesized chemosensors is done by employing different analytical techniques including nuclear magnetic resonance and electronic absorption specrtoscopies. Read More

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miR-296-5p promotes autophagy in mouse LS8 cells under excessive fluoride via AMPK/ULK1 pathways.

Ecotoxicol Environ Saf 2022 Apr 17;235:113362. Epub 2022 Mar 17.

Department of Preventive Dentistry, Shanghai Stomatological Hospital, Fudan University, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, China. Electronic address:

Numerous microRNAs participate in regulating the pathological process of autophagy. We have found miR-296-5p is one of the most significantly down-regulated microRNAs in a high concentration of sodium fluoride. However, it is not clear whether miR-296-5p augments autophagy in dental fluorosis. Read More

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Sodium Fluoride and Sulfur Dioxide Derivatives Induce TGF-β1-Mediated NBCe1 Downregulation Causing Acid-Base Disorder of LS8 Cells.

Biol Trace Elem Res 2022 Mar 19. Epub 2022 Mar 19.

School of Public Health, the key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guizhou, China.

The aim of the present work was to assess whether the combination of sodium fluoride (NaF) and sulfur dioxide derivatives (SO derivatives) affects the expression of the electrogenic sodium bicarbonate cotransporter NBCe1 (SLC4A4), triggering an acid-base imbalance during enamel development, leading to enamel damage. LS8 cells was taken as the research objects and fluorescent probes, quantitative real-time polymerase chain reaction (qRT-PCR), western blot, and factorial analysis were used to clarify the nature of the fluoro-sulfur interaction and the potential signaling pathway involved in the regulation of NBCe1. The results showed that exposure to fluoride or SO derivatives resulted in an acid-base imbalance, and these changes were accompanied by inhibited expression of NBCe1 and TGF-β1; these effects were more significant after fluoride exposure as compared to exposure to SO derivatives. Read More

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A review of molecular mechanisms linked to potential renal injury agents in tropical rural farming communities.

Environ Toxicol Pharmacol 2022 May 15;92:103850. Epub 2022 Mar 15.

Nicholas School of the Environment, Duke University, NC 27708, United States. Electronic address:

The chronic kidney disease of unknown etiology (CKDu) is a global health concern primarily impacting tropical farming communities. Although the precise etiology is debated, CKDu is associated with environmental exposures including heat stress and chemical contaminants such as fluoride, heavy metals, and herbicide glyphosate. However, a comprehensive synthesis is lacking on molecular networks underpinning renal damage induced by these factors. Read More

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Rhizofiltration of combined arsenic-fluoride or lead-fluoride polluted water using common aquatic plants and use of the 'clean' water for alleviating combined xenobiotic toxicity in a sensitive rice variety.

Environ Pollut 2022 Jul 14;304:119128. Epub 2022 Mar 14.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, 700016, West Bengal, India. Electronic address:

Groundwater co-contamination with toxic pollutants like arsenic-fluoride or lead-fluoride is a serious threat for safe rice cultivation, since major stretches of land, involved in cultivation of this staple food crop are presently experiencing severe endemic pollution from these xenobiotic combinations. Preliminary investigations established that the combined pollutants together exerted more phytotoxicity in the widely cultivated indica rice variety Khitish, compared with that exerted by the individual contaminants. Thus, an ecologically sustainable and economically viable phytoremediative strategy was designed where three aquatic plants, viz. Read More

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Fluoride increases the susceptibility of developmental dysplasia of the hip via increasing capsular laxity triggered by cell apoptosis and oxidative stress in vivo and in vitro.

Ecotoxicol Environ Saf 2022 Mar 14;234:113408. Epub 2022 Mar 14.

Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning 110004, China.

The etiology of developmental dysplasia of the hip (DDH) is multifactorial, including breech presentation and hip capsular laxity. In particular, hip laxity is the main contributor to DDH by changing the ratio and distribution of collagens. Also, fluoride (F) affects collagens from various tissue besides bone and tooth. Read More

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Gene expression and alterations of antioxidant enzymes in spleen of rats exposed to fluoride.

J Trace Elem Med Biol 2022 Mar 9;72:126966. Epub 2022 Mar 9.

Department of Zoology and Environmental Sciences, Punjabi University, Patiala 147002, India. Electronic address:

Background: Fluorosis is a slow and progressive process causing metabolic, functional and structural damages affecting many tissues particularly musculoskeletal, dental systems, kidney, liver and brain. It can be rapidly absorbed by passive diffusion through the stomach, small intestine, mouth and skin. Endemic fluorosis is connected to the high concentration of fluoride in drinking water. Read More

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High concentration of sodium fluoride in drinking water induce hypertrophy versus atrophy in mouse skeletal muscle via modulation of sarcomeric proteins.

J Hazard Mater 2022 06 9;432:128654. Epub 2022 Mar 9.

Stem cells and Regenerative medicine centre, Yenepoya research centre, Yenepoya Deemed to be University, University Road, Derlakatte, Mangalore 575018, Karnataka, India. Electronic address:

Fluoride at high doses is a well-known toxic agent for the musculoskeletal system, primarily in bone and cartilage cells. Research on fluoride toxicity concerning particularly on the skeletal muscle is scanty. We hypothesized that during skeletal fluorosis, along with bone, muscle is also affected, so we have evaluated the effects of Sodium fluoride (NaF) on mouse skeletal muscles. Read More

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Cytotoxicity effect of orthodontic miniscrew-implant in different types of mouthwash: An in-vitro study.

J Orthod Sci 2022 28;11. Epub 2022 Jan 28.

Department of Orthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Context: Orthodontic miniscrew implants (OMIs) are widely used as anchorage alternatives, but recent studies revealed the corrosion behavior of OMIs when they come in contact with mouthwashes. The corrosion materials that are released can cause toxicity, allergy, and mutagenicity.

Aims: This study aims to analyze the cytotoxicity effects of OMIs exposed to different types of mouthwash using human gingival fibroblast (HGFs). Read More

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January 2022

In Vitro Biocompatibility of Several Children's Toothpastes on Human Gingival Fibroblasts.

Int J Environ Res Public Health 2022 03 3;19(5). Epub 2022 Mar 3.

Cellular Therapy and Hematopoietic Transplant Group, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca, University of Murcia, 30120 Murcia, Spain.

The European Academy of Paediatric Dentistry has recommended fluoride toothpastes from the eruption of the first teeth in children. Toothpastes stay in the mouth in contact with human gingival fibroblasts (hGFs) for a long time. Thus, the objective of this study was to compare the cytotoxicity of five different commonly used children's toothpastes: Oral B Kids +3 (Procter & Gamble, Alicante, Spain), Fluor Kin Calcium (Kin, Madrid, Spain), PHB Junior (PHB, Barcelona, Spain), Colgate +3 (Colgate Palmolive, Madrid, Spain) and Vitis Kids (Dentaid, Valencia, Spain) on hGFs. Read More

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The Effects of Vitamin D Application on NaF-Induced Cytotoxicity in Osteoblast Cells (hFOB 1.19).

Biol Trace Elem Res 2022 Mar 10. Epub 2022 Mar 10.

Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Turkey.

This study was planned to evaluate the effect of vitamin D administration on cytotoxicity due to fluoride exposure in vitro. NaF (IC50) and vitamin D (proliferative) were applied to human osteoblast (hFOB 1.19) cells. Read More

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Cytotoxic effects of different detergent containing children's toothpastes on human gingival epithelial cells.

BMC Oral Health 2022 03 9;22(1):66. Epub 2022 Mar 9.

Department of Pediatric Dentistry, Faculty of Dentistry, Altinbas University, Istanbul, Turkey.

Background: This study aimed to evaluate possible cytotoxic effects to gingival epithelial cells exposed to children toothpastes containing different detergent.

Methods: Tissues required for the isolation of human gingival epithelial cells were obtained by biopsy during the extraction of the impacted third molar tooth. Toothpaste solutions of different concentrations were prepared from five different children's toothpastes with different detergent contents. Read More

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Stability, dissolution, and cytotoxicity of NaYF-upconversion nanoparticles with different coatings.

Sci Rep 2022 03 8;12(1):3770. Epub 2022 Mar 8.

Department of Biology and CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

Upconversion nanoparticles (UCNPs) have attracted considerable attention owing to their unique photophysical properties. Their utilization in biomedical applications depends on the understanding of their transformations under physiological conditions and their potential toxicity. In this study, NaYF:Yb,Er UCNPs, widely used for luminescence and photophysical studies, were modified with a set of four different coordinatively bound surface ligands, i. Read More

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Stretchable, Breathable, and Stable Lead-Free Perovskite/Polymer Nanofiber Composite for Hybrid Triboelectric and Piezoelectric Energy Harvesting.

Adv Mater 2022 Apr 20;34(17):e2200042. Epub 2022 Mar 20.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Halide-perovskite-based mechanical energy harvesters display excellent electrical output due to their unique ferroelectricity and dielectricity. However, their high toxicity and moisture sensitivity impede their practical applications. Herein, a stretchable, breathable, and stable nanofiber composite (LPPS-NFC) is fabricated through electrospinning of lead-free perovskite/poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and styrene-ethylene-butylene-styrene (SEBS). Read More

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