2,609 results match your criteria Toxicity Ethylene Glycol


Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells.

Biomater Sci 2013 Apr 30;1(4):361-367. Epub 2013 Jan 30.

Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan.

A pH-sensitive nanoparticle was prepared using our original amphiphilic block copolymer, poly(ethylene glycol)-b-poly(4-vinylbenzylphosphonate) (PEG-b-PVBP), which possesses phosphate groups as a side chain of its hydrophobic segment (termed here, phosphate nanoparticle (PNP)). The cationic anticancer drug, doxorubicin (DOX) was incorporated into a PNP (DOX@PNP), and its loading capacity was 320 mg g-PNP. Electrostatic and hydrophobic interactions in the core of the PNP might act synergistically to significantly improve its loading capacity. Read More

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http://dx.doi.org/10.1039/c2bm00156jDOI Listing

Structure effect of carbon nanovectors in regulation of cellular responses.

Biomater Sci 2014 Jan 21;2(1):57-66. Epub 2013 Aug 21.

NCE-Polymer Chemistry Group, Piramal Life Science Ltd., Goregaon, Mumbai-400063, India.

Carbon nanostructures such as multiwalled carbon nanotubes (CNT) and graphene (G) are potential candidates in a large number of biomedical applications. However, there is limited understanding and connection between the physicochemical properties of diverse carbon nanostructures and biological systems, particularly with regard to cellular responses. It is also crucial to understand how the structure and surface composition of carbon nanostructures affect the cellular internalization process. Read More

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http://dx.doi.org/10.1039/c3bm60082cDOI Listing
January 2014

Improvement in mechanical properties and biodegradability of PLA using poly(ethylene glycol) and triacetin for antibacterial wound dressing applications.

Prog Biomater 2020 May 30. Epub 2020 May 30.

Pharmaceutical Science Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran.

Wound is among the most common injuries. A suitable wound dressing has a significant effect on the healing process. In this study, a porous wound dressing was prepared using poly (lactic acid) (PLA) and two plasticizers, polyethylene glycol (PEG) and triacetin (TA), through solvent casting method. Read More

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http://dx.doi.org/10.1007/s40204-020-00131-6DOI Listing

Light-enhanced hypoxia-responsive and azobenzene cleavage-triggered size-shrinkable micelles for synergistic photodynamic therapy and chemotherapy.

Biomater Sci 2020 May 27. Epub 2020 May 27.

Department of Interventional and Vascular surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai 201804, People's Republic of China.

Hypoxia is an important pathological phenomenon due to uncontrolled cancer cell proliferation and insufficient blood flow, which can be used to design hypoxia-responsive nanocarriers for the intelligent treatment of tumor. However, it is difficult to obtain the response of hypoxia-responsive polymers corresponding to the degree of hypoxia in the tumor sites. Therefore, hypoxia-responsive azobenzene-centered copolymers polyoligo (ethylene glycol) methacrylate-block-poly(ε-caprolactone)-azobenzene-poly(ε-caprolactone)-block-poly oligo (ethylene glycol) (POEGMA-b-PCL-Azo-PCL-b-POEGMA) were synthesized and further self-assembled into spherical micelles. Read More

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http://dx.doi.org/10.1039/d0bm00328jDOI Listing

Single versus continued dosing of fomepizole during hemodialysis in ethylene glycol toxicity.

Clin Toxicol (Phila) 2020 May 26:1-5. Epub 2020 May 26.

Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

In cases of ethylene glycol (EG) toxicity requiring hemodialysis (HD), fomepizole is dosed every four hours. HD efficiently clears EG and its toxic metabolites, and it's unclear if multiple doses (MD) of fomepizole improve patient outcomes or whether a single dose (SD) prior to initiation of HD is sufficient. We reviewed cases of EG toxicity at a toxicology referral center from 2008 to 2018. Read More

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http://dx.doi.org/10.1080/15563650.2020.1770780DOI Listing

Exploration of small RNA biomarkers for testicular injury in the serum exosomes of rats.

Toxicology 2020 May 8;440:152490. Epub 2020 May 8.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address:

Testicular injury is often observed in drug development. Serum hormones are usually used as noninvasive biomarkers for testicular injury; however, their sensitivities are low. Therefore, it is difficult to monitor testicular injury in drug development. Read More

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http://dx.doi.org/10.1016/j.tox.2020.152490DOI Listing

Systematic evaluation of design features enables efficient selection of Π electron-stabilized polymeric micelles.

Int J Pharm 2020 May 7;584:119409. Epub 2020 May 7.

Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany; Department of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands. Electronic address:

Polymeric micelles (PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) loaded with paclitaxel (PTX-PM) have shown promising results in overcoming the suboptimal efficacy/toxicity profile of paclitaxel. To get insight into the stability of PTX-PM formulations upon storage and to optimize their in vivo tumor-targeted drug delivery properties, we set out to identify a lead PTX-PM formulation with the optimal polymer composition. To this end, PM based on four different mPEG-b-p(HPMA-Bz) block copolymers with varying molecular weight of the hydrophobic block (17-3 kDa) were loaded with different amounts of PTX. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119409DOI Listing

Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH Responsive Hepatocellular Carcinoma-Targeted Drug Delivery.

Curr Med Chem 2020 May 4. Epub 2020 May 4.

Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin 541004. China.

Background: Hepatocellular carcinoma (HCC) seriously affects human health, especially, it easily develop multi-drug resistance (MDR) result in treatment failure. There is an urgent need to develop highly effective and low-toxicity therapeutic agents to treat HCC and overcome its MDR. Targeted drug delivery systems (DDS) for cancer therapy, including nanoparticles, lipids, micelles and liposomes, have been studied for decades. Read More

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http://dx.doi.org/10.2174/0929867327666200505085756DOI Listing

SP94 Peptide-Functionalized PEG-PLGA Nanoparticle Loading with Cryptotanshinone for Targeting Therapy of Hepatocellular Carcinoma.

AAPS PharmSciTech 2020 Apr 27;21(4):124. Epub 2020 Apr 27.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.

To achieve improved drug delivery efficiency to hepatocellular carcinoma (HCC), biodegradable poly (ethylene glycol)-poly (lactic-co-glycolic acid) (PEG-PLGA) nanoparticles (NP), surface-modified with SP94 peptide, were designed for the efficient delivery of cryptotanshinone to the tumor for the treatment of HCC. Cryptotanshinone NP and SP94-NP were prepared by using nanoprecipitation. The physicochemical and pharmaceutical properties of the NP and SP94-NP were characterized, and the release kinetics suggested that both NP and SP94-NP provided continuous, slow release of cryptotanshinone for 48 h. Read More

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http://dx.doi.org/10.1208/s12249-020-01655-7DOI Listing

Molecular crowding electrolytes for high-voltage aqueous batteries.

Nat Mater 2020 Apr 20. Epub 2020 Apr 20.

Electrochemical Energy and Interfaces Laboratory, Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

Developing low-cost and eco-friendly aqueous electrolytes with a wide voltage window is critical to achieve safe, high-energy and sustainable Li-ion batteries. Emerging approaches using highly concentrated salts (21-55 m (mol kg)) create artificial solid-electrode interfaces and improve water stability; however, these approaches raise concerns about cost and toxicity. Molecular crowding is a common phenomenon in living cells where water activity is substantially suppressed by molecular crowding agents through altering the hydrogen-bonding structure. Read More

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http://dx.doi.org/10.1038/s41563-020-0667-yDOI Listing
April 2020
36.425 Impact Factor

Sustained-release voriconazole-thermogel for subconjunctival injection in horses: ocular toxicity and in-vivo studies.

BMC Vet Res 2020 Apr 16;16(1):115. Epub 2020 Apr 16.

J. T. Vaughan Large Animal Teaching Hospital, Auburn University, Auburn, AL, USA.

Background: Keratomycosis is a relatively common, sight threatening condition in horses, where treatment is often prolonged and costly. Subconjunctival (SCo) injections offer less resistance to drug diffusion than the topical route, resulting in better penetration to the ocular anterior segment. Voriconazole, a second generation triazole antifungal, is effective against common fungal organisms causing keratomycosis. Read More

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http://dx.doi.org/10.1186/s12917-020-02331-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160932PMC

Neurovascular Organotypic Culture Models Using Induced Pluripotent Stem Cells to Assess Adverse Chemical Exposure Outcomes.

Appl In Vitro Toxicol 2019 Jun 17;5(2):92-110. Epub 2019 Jun 17.

Human Models for Analysis of Pathways Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Human-induced pluripotent stem cells (iPSCs) represent a promising cell source for the construction of organotypic culture models for chemical toxicity screening and characterization. To characterize the effects of chemical exposure on the human neurovasculature, we constructed neurovascular unit (NVU) models consisting of endothelial cells (ECs) and astrocytes (ACs) derived from human-iPSCs, as well as human brain-derived pericytes (PCs). The cells were cocultured on synthetic poly(ethylene glycol) (PEG) hydrogels that guided the self-assembly of capillary-like vascular networks. Read More

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http://dx.doi.org/10.1089/aivt.2018.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594538PMC

Injectable Click Polypeptide Hydrogels via Tetrazine-Norbornene Chemistry for Localized Cisplatin Release.

Polymers (Basel) 2020 Apr 10;12(4). Epub 2020 Apr 10.

CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Injectable, covalently cross-linked hydrogels have been widely investigated in drug delivery systems due to their superior mechanical properties and long-term stability. Conventional covalently cross-linked hydrogels are formed by chemical reactions that may interfere with natural biochemical processes. In this work, we developed an injectable polypeptide hydrogel via an inverse electron demand Diels-Alder reaction between norbornene modified poly(L-glutamic acid) (PLG-Norb) and tetrazine functionalized four-arm poly(ethylene glycol) (4aPEG-T) for localized release of cisplatin (CDDP). Read More

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http://dx.doi.org/10.3390/polym12040884DOI Listing

Nanoformulated Bioactive Compounds Derived from Different Natural Products Combat Pancreatic Cancer Cell Proliferation.

Int J Nanomedicine 2020 31;15:2259-2268. Epub 2020 Mar 31.

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.

Purpose: This study was designed to determine the potential effect of nanoencapsulated bioactive compounds from different natural sources on human pancreatic cancer.

Background: Pancreatic cancer carries the highest fatality rate among all human cancers because of its high metastatic potential and late presentation at the time of diagnosis. Hence there is a need for improved methods to prevent and treat it. Read More

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http://dx.doi.org/10.2147/IJN.S238256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127850PMC

Study on the optical and biological properties in vitro of IR808-PEG-FA.

J Biomed Mater Res A 2020 Apr 10. Epub 2020 Apr 10.

Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, China.

IR808, an IR780 derivative, is capable of fluorescently imaging and photodynamic therapy in vitro and in vivo. However, its application is greatly hampered by hydrophobicity, toxicity and nonspecific delivery to the targeting tissue and that causes accumulation in the liver and kidney. In order to overcome these limitations, we prepared IR808-PEG-FA from IR808, amino-terminated poly(ethylene glycol) (NH -PEG-NH , denoted as PEG) and folate (FA). Read More

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http://dx.doi.org/10.1002/jbm.a.36946DOI Listing

Anti-PD-L1-modified and ATRA-loaded nanoparticles for immuno-treatment of oral dysplasia and oral squamous cell carcinoma.

Nanomedicine (Lond) 2020 Apr 7;15(10):951-968. Epub 2020 Apr 7.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China.

To develop nanomedicines for immuno-therapy of oral dysplasia and oral squamous cell carcinoma. All-trans retinoic acid (ATRA)-poly(lactide-co-glycolide acid) (PLGA)-poly(ethylene glycol) (PEG)-programmed death-ligand 1 (PD-L1) nanomedicines were fabricated by loading ATRA into PLGA-PEG nanocarriers and modification using an anti-PD-L1 antibody. ATRA-PLGA-PEG-PD-L1 nanoparticles showed fast cellular uptake, significantly inhibited proliferation and induced apoptosis in DOK and CAL27 cells. Read More

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http://dx.doi.org/10.2217/nnm-2019-0397DOI Listing

Microcapsule-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium.

J Mater Chem B 2019 04 7;7(14):2330-2337. Epub 2019 Mar 7.

Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.

Transdermal delivery of diclofenac sodium (DS) has drawn much attention for the advantages of avoiding first-pass metabolism, reduced systemic toxicity and better patient compliance, but the successful translation of reported transdermal drug delivery systems (TDDSs) is still limited by poor skin permeability and uncontrollable drug release. Herein, we designed and fabricated a novel ultrasound responsive TDDS by embedding DS-loaded polyester microcapsules into a hydrogel patch based on four-armed poly(ethylene glycol). The rational design endows the microcapsule-embedded hydrogel patch with good biocompatibility, excellent skin-adhesion properties and well-controlled ultrasound responsive release behavior. Read More

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http://dx.doi.org/10.1039/c8tb02928hDOI Listing

Efficacy of Herbmed Plus in urolithic rats: An experimental study.

J Ayurveda Integr Med 2020 Mar 30. Epub 2020 Mar 30.

Department of Urology, AMAI Trust's Ace Hospital and Research Centre, Pune, India.

Background: In Ayurveda, several herbs and formulations are available for the treatment of Urolithiasis. However, they are not systematically evaluated for their safety, efficacy, indication and limitations. Herbmed Plus is one such herbal formulation that has been known for the management of urinary tract disorders. Read More

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http://dx.doi.org/10.1016/j.jaim.2019.09.007DOI Listing

Trastuzumab targeted micellar delivery of docetaxel using dendron-polymer conjugates.

Biomater Sci 2020 May;8(9):2600-2610

Department of Chemistry, Bogazici University, Istanbul, 34342, Turkey. and Center for Life Sciences and Technologies, Bogazici University, Istanbul, 34342, Turkey.

Incorporation of a therapeutic antibody into nanosized drug delivery systems can improve their target specificity. This work reports an antibody-conjugated targeted delivery system composed of polymer-dendron conjugates. Trastuzumab is chosen as the targeting moiety, since it is clinically used against tumor cells expressing HER2 receptors. Read More

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http://dx.doi.org/10.1039/c9bm01764jDOI Listing

The combination of Diels-Alder reaction and redox polymerization for preparation of functionalized CNTs for intracellular controlled drug delivery.

Mater Sci Eng C Mater Biol Appl 2020 Apr 18;109:110442. Epub 2019 Nov 18.

Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, China; Department of Chemistry and Center for Nanotechnology and Institute of Biomedical Technology, Chung-Yuan Christian University, Chung-Li 32023, Taiwan. Electronic address:

Carbon nanotubes (CNTs) are a novel type of one-dimensional carbon nanomaterials that have been widely utilized for biomedical applications such as drug delivery, cancer photothermal treatment owing to their high surface area and unique interaction with cell membranes. However, their biomedical applications are still impeded by some drawbacks, including poor water dispersibility, lack of functional groups and toxicity. Therefore, surface modification of CNTs to overcome these issues should be importance and of great interest. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110442DOI Listing

The critical role of the dispersant agents in the preparation and ecotoxicity of nanomaterial suspensions.

Environ Sci Pollut Res Int 2020 Jun 29;27(16):19845-19857. Epub 2020 Mar 29.

Research Center in Chemistry (CIQ), Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.

This work reports the role of different dispersants, namely, polyethylene glycol (PEG 200 2%), ethylene glycol 5%, ethanol 2%, dimethyl sulfoxide (DMSO 5%), and polyvinyl alcohol (PVA 5%) in the toxicity profile of several commercial nanomaterials (NM), such as hydrophilic and hydrophobic TiO, hydrophilic SiO, SiO in aqueous suspension (aq), and ZnO towards the bioluminescent bacterium Aliivibrio fischeri. The majority of NM showed tendency to form agglomerates in the different dispersants. Although some particle agglomeration could be detected, DMSO at 5% was the best dispersant for hydrophobic TiO NM while PVA at 5% was the most effective dispersant for the other types of NM. Read More

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http://dx.doi.org/10.1007/s11356-020-08323-0DOI Listing

HS-Donating trisulfide linkers confer unexpected biological behaviour to poly(ethylene glycol)-cholesteryl conjugates.

J Mater Chem B 2020 May 30;8(17):3896-3907. Epub 2020 Mar 30.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.

Inspired by the properties of the naturally occurring HS donor, diallyl trisulfide (DATS, extracted from garlic), the biological behaviour of trisulfide-bearing PEG-conjugates was explored. Specifically, three conjugates comprising an mPEG tail and a cholesteryl head were investigated: conjugates bridged by a trisulfide linker (T), a disulfide linker (D) or a carbamate linker (C), and a fourth comprising two mPEG tails bridged by a trisulfide linker (P). HS testing using both a fluorescent chemical probe in HEK293 cells and an amperometric sensor to monitor release in suspended cells, demonstrated the ability of the trisulfide conjugates, T and P, to release HS in the presence of cellular thiols. Read More

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http://dx.doi.org/10.1039/c9tb02614bDOI Listing

Well-Defined Diblock Poly(ethylene glycol)--Poly(ε-caprolactone)-Based Polymer-Drug Conjugate Micelles for pH-Responsive Delivery of Doxorubicin.

Materials (Basel) 2020 Mar 26;13(7). Epub 2020 Mar 26.

Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

Nanoparticles have emerged as versatile carriers for various therapeutics and can potentially treat a wide range of diseases in an accurate and disease-specific manner. Polymeric biomaterials have gained tremendous attention over the past decades, owing to their tunable structure and properties. Aliphatic polyesters have appealing attributes, including biodegradability, non-toxicity, and the ability to incorporate functional groups within the polymer backbone. Read More

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http://dx.doi.org/10.3390/ma13071510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177263PMC
March 2020
2.651 Impact Factor

Effect of L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice.

Iran J Med Sci 2020 Mar;45(2):134-139

Department of Pharmacognosy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Kidney stone disease can be quite painful, recurrent, and affects many people. Despite advances in drug therapy, there is still a need to find effective drugs with fewer complications for long-term treatment of kidney stones and to prevent its recurrence. The present study aimed to evaluate the effect of L. Read More

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http://dx.doi.org/10.30476/IJMS.2019.45774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071555PMC

Preparation and characterization of Keratin-PEG conjugate-based micelles as a tumor microenvironment-responsive drug delivery system.

J Biomater Sci Polym Ed 2020 Jun 5;31(9):1163-1178. Epub 2020 Apr 5.

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.

Keratin-based drug carriers have attracted great interest due to their intrinsic biocompatibility and tumor micro-environmental responsiveness. In the study, keratin was first extracted from human hair with reduction method. The reduced keratin was successively conjugated with poly(ethylene glycol) (PEG) thiol Michael addition reaction and iodoacetic acid (IAA) substitution reaction to impart both physical stability and acidity responsiveness. Read More

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http://dx.doi.org/10.1080/09205063.2020.1747044DOI Listing
June 2020
1.648 Impact Factor

Preparation of polyethylene glycol-polyacrylic acid block copolymer micelles with pH/hypoxic dual-responsive for tumor chemoradiotherapy.

Colloids Surf B Biointerfaces 2020 Jul 4;191:110943. Epub 2020 Mar 4.

Department of Radiology, West China Hospital of Sichuan University, No. 37, Guangxue Lane, Chengdu 610093, China. Electronic address:

Block copolymers of poly(ethylene glycol)-poly(acrylic acid) linked with metronidazole (MN-PAA-PEG) were prepared via carbodiimide and esterification methods, and self-assembled into core-shell micelles as nano radiosensitizers and carriers of doxorubicin (DOX) delivery. These DOX/MN-PAA-PEG micelles exhibited good pH value and hypoxia dual-responsive properties via analyzing the change of micelle size and drug‒release behavior under hypoxia humor condition. The results of the cell test indicated that DOX was efficiently delivered by DOX/MN-PAA-PEG micelles into the cell nuclei. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.110943DOI Listing

Bioresorbable hydrogels prepared by photo-initiated crosslinking of diacrylated PTMC-PEG-PTMC triblock copolymers as potential carrier of antitumor drugs.

Saudi Pharm J 2020 Mar 31;28(3):290-299. Epub 2020 Jan 31.

Institut Europeen des Membranes, UMR CNRS 5635, Universite de Montpellier, 34095 Montpellier, France.

PTMC-PEG-PTMC triblock copolymers were prepared by ring-opening polymerization of trimethylene carbonate (TMC) in the presence of dihydroxylated poly(ethylene glycol) (PEG) with Mn of 6000 and 10,000 as macro-initiator. The copolymers with different PTMC block Lengths and the two PEGs were end functionalized with acryloyl chloride. The resulting diacrylated PEG-PTMC-DA and PEG-DA were characterized by using NMR, GPC and DSC. Read More

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http://dx.doi.org/10.1016/j.jsps.2020.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078571PMC

Traditional Medications Mixed with Ethylene Glycol in a Nigerian Patient on Hemodialysis.

Cureus 2020 Feb 11;12(2):e6950. Epub 2020 Feb 11.

Nephrology, Baylor College of Medicine, Houston, USA.

Unregulated traditional medications and their solvents are nephrotoxic. We present a case of a 49-year-old Nigerian male with a 10-year history of diabetes mellitus and hypertension who was ingesting a traditional, herbal medication as an aphrodisiac for erectile dysfunction. He had a rapid decline in kidney function over a period of one year and the patient commenced thrice weekly hemodialysis. Read More

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http://dx.doi.org/10.7759/cureus.6950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067357PMC
February 2020

Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles.

Mol Pharm 2020 Apr 20;17(4):1415-1427. Epub 2020 Mar 20.

Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

The therapeutic efficacy of chemotherapy in many types of hematological malignancies and solid tumors is dramatically hindered by multidrug resistance (MDR). This work presents a combination strategy of pretreatment of MDA-MB-231/MDR1 cells with quercetin (QU) followed by doxorubicin (DOX) to overcome MDR, which can be delivered by mixed micelles composed of the reduction-sensitive hyaluronic acid-based conjugate and d-α-tocopheryl poly(ethylene glycol) 1000 succinate. The combination strategy can enhance the cytotoxicity of DOX on MDA-MB-231/MDR1 cells by increasing intracellular DOX accumulation and facilitating DOX-induced apoptosis. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00138DOI Listing

A polymeric nanocarrier with a tumor acidity-activatable arginine-rich (R) peptide for enhanced drug delivery.

Biomater Sci 2020 Apr;8(8):2255-2263

Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, P. R. China. and School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 510006, P. R. China and Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, P.R. China.

Cell-penetrating peptides (CPPs) have been considered as a powerful tool to improve the intracellular and nuclear delivery efficiency of nanocarriers. However, their clinical application is limited because of their nonspecific targeting function, short half-life, and severe system toxicity. Herein, we have developed a polymeric nanocarrier with a tumor acidity-activatable arginine-rich (R9) peptide for targeted drug delivery. Read More

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http://dx.doi.org/10.1039/d0bm00069hDOI Listing

[Ethylene glycol intoxication requires a multidisciplinary approach].

Rev Med Suisse 2020 Feb;16(683):404-408

Service de néphrologie, Département de médecine, HUG, 1211 Genève 14.

Cheap and easy to access, ethylene glycol is used in the synthesis of antifreezes. Intoxication has potentially irreversible morbid consequences. Ingestion of a small amount can lead to death. Read More

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February 2020

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy.

Int J Mol Sci 2020 Feb 27;21(5). Epub 2020 Feb 27.

Institut des Sciences Moléculaires d'Orsay, CNRS, Université Paris-Saclay, 91405 Orsay, France.

Nanomedicine has stepped into the spotlight of radiation therapy over the last two decades. Nanoparticles (NPs), especially metallic NPs, can potentiate radiotherapy by specific accumulation into tumors, thus enhancing the efficacy while alleviating the toxicity of radiotherapy. Water radiolysis is a simple, fast and environmentally-friendly method to prepare highly controllable metallic nanoparticles in large scale. Read More

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http://dx.doi.org/10.3390/ijms21051619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084439PMC
February 2020

Polymer Nanoformulation of Sorafenib and All-Trans Retinoic Acid for Synergistic Inhibition of Thyroid Cancer.

Front Pharmacol 2019 3;10:1676. Epub 2020 Feb 3.

Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Part of differentiated thyroid cancer will relapse or develop into dedifferentiated thyroid cancer after standard therapy, such as surgery or radionuclide therapy. Sorafenib (SOR) is recommended for the treatment of advanced or radioiodine-refractory thyroid cancer. The monotherapy using SOR is often hampered by its modest efficacy, serve systemic toxicity, and high occurrence of drug resistance. Read More

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http://dx.doi.org/10.3389/fphar.2019.01676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008594PMC
February 2020

Development of Amphotericin B Micellar Formulations Based on Copolymers of Poly(ethylene glycol) and Poly(ε-caprolactone) Conjugated with Retinol.

Pharmaceutics 2020 Feb 25;12(3). Epub 2020 Feb 25.

Grupo de Investigación en Macromoléculas, Facultad de Ciencias, Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 N° 26-85, edificio 451 of. 449 Bogotá, Colombia.

Amphotericin B (AmB) is a broad spectrum of antifungal drug used to treat antifungal diseases. However, due to the high toxicity of AmB, treated patients may suffer the risk of side effects, such as renal failure. Nanoencapsulation strategies have been reported to elicit low toxicity, albeit most of them possess low encapsulation efficiency. Read More

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http://dx.doi.org/10.3390/pharmaceutics12030196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150995PMC
February 2020

Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity.

Nanoscale 2020 Mar;12(9):5332-5340

Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA. and Interdepartmental Biological Sciences Program, Northwestern University, Evanston, Illinois 60208, USA and Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, USA and Simpson Querrey Institute, Northwestern University, Chicago, Illinois 60611, USA.

Bicontinuous nanospheres (BCNs) are underutilized self-assembled nanostructures capable of simultaneous delivery of both hydrophilic and hydrophobic payloads. Here, we demonstrate that BCNs assembled from poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS), an oxidation-sensitive copolymer, are stably retained within cell lysosomes following endocytosis, resisting degradation and payload release for days until externally triggered. The oxygen scavenging properties and enhanced stability of the bicontinuous PEG-b-PPS nanoarchitecture significantly protected cells from typically cytotoxic application of pro-apoptotic photo-oxidizer pheophorbide A and chemotherapeutic camptothecin. Read More

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http://dx.doi.org/10.1039/c9nr10921hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197099PMC

Anaerobic bioconversion of petrochemical wastewater to biomethane in a semi-continuous bioreactor: Biodegradability, mineralization behaviors and methane productivity.

Bioresour Technol 2020 May 12;304:123005. Epub 2020 Feb 12.

The State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 200092 Shanghai, PR China.

Petrochemical wastewaters treatment represents a serious challenge due to the high toxicity and complex chemical components. In this study, the biodegradability, mineralization behaviors and methane productivity of eight different types of petrochemical wastewaters were evaluated in series of semi-continuous bioreactors. Methane production strongly depended on the characteristics of wastewaters and chemical constituents. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123005DOI Listing

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle.

ACS Nano 2020 03 21;14(3):2827-2846. Epub 2020 Feb 21.

Department of Radiation Oncology, Houston Methodist Research Institute, Houston, Texas 77030, United States.

Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of the hemorrhage itself as well as multiple deleterious effects of blood and its breakdown products such as hemin and free iron. While oxidative injury and genomic damage have been seen following ICH, the details of this injury and implications remain unclear. Here, we discovered that, while free iron produced mostly reactive oxygen species (ROS)-related single-strand DNA breaks, hemin unexpectedly induced rapid and persistent nuclear and mitochondrial double-strand breaks (DSBs) in neuronal and endothelial cell genomes and in mouse brains following experimental ICH comparable to that seen with γ radiation and DNA-complexing chemotherapies. Read More

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http://dx.doi.org/10.1021/acsnano.9b05821DOI Listing

SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo.

ACS Appl Mater Interfaces 2020 Mar 2;12(10):11307-11319. Epub 2020 Mar 2.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, California 94305, United States.

Gene-directed enzyme-prodrug therapy (GDEPT) is a promising approach for cancer therapy, but it suffers from poor targeted delivery in vivo. Polyethylenimine (PEI) is a cationic polymer efficient in delivering negatively charged nucleic acids across cell membranes; however, it is highly toxic in vivo. Hence, we efficiently reduced PEI toxicity without compromising its transfection efficiency by conjugating it with poly(d,l-lactic--glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) as triblock copolymers through a multistep synthetic process. Read More

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http://dx.doi.org/10.1021/acsami.9b20071DOI Listing

Dynamic Covalent C═C Bond, Cross-Linked, Injectable, and Self-Healable Hydrogels via Knoevenagel Condensation.

Biomacromolecules 2020 Mar 25;21(3):1234-1242. Epub 2020 Feb 25.

School of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

Hydrogels have a wide range of applications in the fields of biomedicine, flexible electronics, and bionics. In this study, injectable and self-healable hydrogels were first prepared based on a dynamic covalent C═C bond formed via the Knoevenagel condensation reaction between poly(ethylene glycol) dicyanoacetate and water-soluble poly(vanillin acrylate). Three kinds of catalysts (phosphate buffer, zeolitic imidazolate framework-8, and tertiary amine) were used in Knoevenagel condensation for preparing hydrogels. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01689DOI Listing

A method for the permeabilization of live larvae to small molecules and cryoprotectants.

Fly (Austin) 2020 Feb 9:1-5. Epub 2020 Feb 9.

Institute of Ageing & Chronic Disease, University of Liverpool, Liverpool, UK.

The larvae of is a model organism widely used to study the muscular and nervous systems. larvae are surrounded by a waxy cuticle that prevents permeation by most substances. Here we develop a method to remove this layer, rendering the larvae permeable to small molecules without causing death, allowing the larvae to develop to adulthood and reproduce. Read More

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http://dx.doi.org/10.1080/19336934.2020.1724051DOI Listing
February 2020

Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers.

Nat Commun 2020 02 5;11(1):721. Epub 2020 Feb 5.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors, among which 4,6-di-O-(methoxy-diethyleneglycol)-myo-inositol-1,2,3,5-tetrakis(phosphate), (OEG)-IP4, displays increased in vitro activity, as well as more favorable pharmacokinetic and safety profiles than IP6 after subcutaneous injection. (OEG)-IP4 potently stabilizes calciprotein particle (CPP) growth, consistently demonstrates low micromolar activity in different in vitro models of VC (i. Read More

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http://dx.doi.org/10.1038/s41467-019-14091-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002685PMC
February 2020
10.742 Impact Factor

Biocompatibility and paclitaxel/cisplatin dual-loading of nanotubes prepared from poly(ethylene glycol)-polylactide-poly(ethylene glycol) triblock copolymers for combination cancer therapy.

Saudi Pharm J 2019 Nov 30;27(7):1025-1035. Epub 2019 Aug 30.

Institut Européen des Membranes, UMR CNRS 5635, Universitéde Montpellier, 34095 Montpellier, France.

Nanotubes were prepared by self-assembly of the copolymer using co-solvent evaporation method. The biocompatibility of the nanotubes was assessed in comparison with spherical micelles and filomicelles prepared from poly(ethylene glycol)-poly(L-lactide-co-glycolide) (PEG-PLGA) and poly(ethylene glycol)-poly(L-lactide) (PEG-PLA), respectively. Several aspects of biocompatibility of the aggregates were considered, including agar diffusion and MTT assay, release of cytokines, hemolysis, protein adsorption, dynamic clotting , and Zebrafish embryonic compatibility . Read More

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http://dx.doi.org/10.1016/j.jsps.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978636PMC
November 2019

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics.

J Nanobiotechnology 2020 Jan 15;18(1):14. Epub 2020 Jan 15.

Clinic for Orthopedic Surgery, NIFE-Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, Hannover Medical School, Stadtfelddamm 34, 30625, Hannover, Germany.

Background: In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibiotics, and still often fail. Drug-loaded magnetic nanoparticles are very promising for local selective therapy, enabling lower systemic antibiotic doses and reducing adverse side effects. Read More

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http://dx.doi.org/10.1186/s12951-020-0578-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964035PMC
January 2020

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy.

ACS Nano 2020 02 21;14(2):1468-1481. Epub 2020 Jan 21.

Department of Chemistry , University of Georgia , Athens , Georgia 30602 , United States.

Radiotherapy remains a major treatment modality for cancer types such as non-small cell lung carcinoma (or NSCLC). To enhance treatment efficacy at a given radiation dose, radiosensitizers are often used during radiotherapy. Herein, we report a nanoparticle agent that can selectively sensitize cancer cells to radiotherapy. Read More

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http://dx.doi.org/10.1021/acsnano.9b05976DOI Listing
February 2020
12.881 Impact Factor

Biguanide-Derived Polymeric Nanoparticles Kill MRSA Biofilm and Suppress Infection .

ACS Appl Mater Interfaces 2020 May 14;12(19):21231-21241. Epub 2020 Jan 14.

Centre for Antimicrobial Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore.

Methicillin-resistant (MRSA) is a significant cause of drug-resistant infections. Its propensity to develop biofilms makes it especially resistant to conventional antibiotics. We present a novel nanoparticle (NP) system made from biocompatible -127 surfactant, annic acid (TA), and biguanide-based olymetformin (MET) (termed FTP NPs), which can kill MRSA biofilm bacteria effectively and and which has excellent biocompatibility. Read More

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http://dx.doi.org/10.1021/acsami.9b17747DOI Listing

An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction.

J Mater Chem B 2020 Feb 13;8(5):980-992. Epub 2020 Jan 13.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China. and Zhuhai Fudan Innovation Institute, Zhuhai, Guangdong 51900, China.

Localized administration of anti-inflammatory agents benefits patients after myocardial infarction (MI) by repressing/modulating inflammatory response of the MI region and thus accelerating repair of the impaired tissues. Colchicine (Col), an ancient natural drug, has excellent anti-inflammatory effects; however, its utilization is strictly limited due to its severe systemic toxicity and narrow therapeutic window. In this study, we developed an intramyocardial delivery system of Col using an injectable, thermosensitive poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) polymer hydrogel as the vehicle for the treatment of MI while minimizing its systemic toxicity. Read More

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http://dx.doi.org/10.1039/c9tb02523eDOI Listing
February 2020

Nanotoxicology at the particle/micelle frontier: influence of core-polymerization on the intracellular distribution, cytotoxicity and genotoxicity of polydiacetylene micelles.

Nanoscale 2020 Jan 9;12(4):2452-2463. Epub 2020 Jan 9.

Institut Galien Paris-Sud, Univ. Paris-Sud, Cnrs, Université Paris-Saclay, Chatenay-Malabry, France.

The understanding of the cellular uptake and the intracellular fate of nanoparticles and their subsequent influence on cell viability is challenging as far as micelles are concerned. Such systems are dynamic by nature, existing as unimers under their critical micelle concentration (CMC), and as micelles in equilibrium with unimers above the CMC, making canonical dose-response relationships difficult to establish. The purpose of this study was to investigate the in vitro cytotoxicity and uptake of two micellar sytems that are relevant for drug delivery. Read More

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http://dx.doi.org/10.1039/c9nr08714aDOI Listing
January 2020

Celastrol-Loaded Galactosylated Liposomes Effectively Inhibit AKT/c-Met-Triggered Rapid Hepatocarcinogenesis in Mice.

Mol Pharm 2020 Mar 3;17(3):738-747. Epub 2020 Feb 3.

Key Laboratory of Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine, Wuhan 430065, China.

Our previous study proved that celastrol was a potential candidate for hepatocellular carcinoma (HCC) therapy. However, poor water solubility and toxic side effects may restrict its clinical application. To overcome these shortcomings and optimize its antitumor efficacy, we developed galactosylated liposomes using galactose-modified 1,2-distearoyl--glycero-3-phosphoethanolamine-poly(ethylene glycol) to deliver celastrol (C-GPL). Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00428DOI Listing

Reduction-sensitive poly(ethylene glycol)-polypeptide conjugate micelles for highly efficient intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin.

Nanotechnology 2020 Apr 3;31(16):165102. Epub 2020 Jan 3.

The non-specific biodistribution of traditional chemotherapeutic drugs against tumors is the key factor that causes systemic toxicity and hinders their clinical application. In this study, a reduction-sensitive polymer conjugate micelle was manufactured to achieve tumor-specific targeting, reduce toxic side-effects and improve anti-tumor activity of a natural anti-cancer drug, hydroxycamptothecin (HCPT). Therefore, HCPT was conjugated with methoxy-poly(ethylene glycol)-poly(β-benzyl-L-aspartate) (mPEG-PBLA) by a disulfide bond or succinate bond for the first time to obtain the mPEG-PBLA-SS-HCPT (PPSH) and mPEG-PBLA-CC-HCPT (PPCH) that would form micelles after high-speed agitation and dialysis. Read More

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http://dx.doi.org/10.1088/1361-6528/ab6749DOI Listing

Chlorin e6 Conjugated Methoxy-Poly(Ethylene Glycol)-Poly(D,L-Lactide) Glutathione Sensitive Micelles for Photodynamic Therapy.

Pharm Res 2020 Jan 2;37(2):18. Epub 2020 Jan 2.

Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Medchal, Hyderabad, Telangana, 500078, India.

Purpose: In this study, we developed a polymeric micellar system for glutathione-mediated intracellular delivery of a photosensitizer, chlorin e6 (Ce6) by synthesizing an amphiphilic polymer, methoxy-poly(ethylene glycol)-poly(D,L-lactide)-disulfide-Ce6 (mPEG-PLA-S-S-Ce6), which self-assembled in aqueous environment to form micelles.

Methods: The polymer-drug conjugate was characterized by NMR. The singlet oxygen (O) generation and in vitro release of Ce6 micelles were evaluated. Read More

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http://dx.doi.org/10.1007/s11095-019-2750-0DOI Listing
January 2020
3.420 Impact Factor