2,371 results match your criteria Toxicity Ethylene Glycol


Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether.

Toxicol Sci 2019 Feb 15. Epub 2019 Feb 15.

Brown University, Providence, RI, USA.

Testicular histology and semen parameters are considered the gold standards when determining male reproductive toxicity. Ethylene glycol monomethyl ether (EGME) is a testicular toxicant with well-described effects on histopathology and sperm parameters. To compare the predictivity and sensitivity of molecular biomarkers of testicular toxicity to the traditional endpoints, small RNAs in the sperm were analyzed by next generation RNA-sequencing (RNA-seq). Read More

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http://dx.doi.org/10.1093/toxsci/kfz041DOI Listing
February 2019

Endoplasmic reticulum-targeted phototherapy using one-step synthesized trace metal-doped carbon-dominated nanoparticles: Laser-triggered nucleolar delivery and increased tumor accumulation.

Acta Biomater 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, Jiangsu, PR China. Electronic address:

Lysosomal entrapment and liver accumulation are the two main obstacles faced by many anticancer drugs for achieving satisfactory therapeutic outcomes. Here, we develop a facile one-step hydrothermal synthetic route to prepare trace metal (M)-, N-, and O-doped carbon-dominated nanoparticles (termed as MNOCNPs, M = Ni, Pd, or Cu, metal content: < 0.1 mol %) with exceptional photothermal properties (e. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.005DOI Listing
February 2019
2 Reads

pH-Responsive polymeric nanocarriers for efficient killing of cariogenic bacteria in biofilms.

Biomater Sci 2019 Feb 6. Epub 2019 Feb 6.

College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China. and State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.

Traditional antibacterial treatments, such as chlorhexidine (CHX), destroy cariogenic biofilms. However, they exert negative effects in clinical applications, for example, teeth staining, taste disturbance and harm to oral tissue after a long-term exposure. Therefore, biocompatible strategies for efficient antibacterial drug delivery are in high demand. Read More

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http://dx.doi.org/10.1039/c8bm01640bDOI Listing
February 2019
1 Read

Gold Nanorods-Based Smart Nanoplatforms for Synergic Thermotherapy and Chemotherapy of Tumor Metastasis.

ACS Appl Mater Interfaces 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School , No. 321 Zhongshan Road , Nanjing 210008 , China.

The combination therapy of photothermal therapy and chemotherapy as a promising strategy has drawn extensive attention by overcoming the limitations of conventional treatments in tumor therapy. Gold nanorods-based nanoplatforms were herein designed by integrating doxorubicin (DOX)- and polydopamine-coated gold nanorods (GNRs@PDA) for tumor metastasis inhibition and multifunctional drug delivery. The GNRs@PDA-poly(ethylene glycol) (PEG)-DOX nanocomplex showed robust stability and excellent near-infrared (NIR) photothermal conversion efficiency under laser irradiation. Read More

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http://dx.doi.org/10.1021/acsami.8b21784DOI Listing
February 2019
1 Read

Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles.

Drug Metab Pers Ther 2019 Feb 1. Epub 2019 Feb 1.

Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan, Iran.

Considerable development in the application of injectable drug delivery systems for cancer therapy has occurred in the last few decades. These improvements include liposomes, lipid nanoparticles (LNPs), and other nanoparticles with or without macromolecular conjugates. For example, liposomal doxorubicin modified by poly(ethylene glycol) (Doxil) was the first liposome with anti-cancer effects which was approved by the US Food and Drug Administration, whereas Abraxane (modified albumin nanoparticles loaded by paclitaxel) was recently confirmed for the treatment of breast cancer. Read More

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http://www.degruyter.com/view/j/dmdi.ahead-of-print/dmpt-201
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http://dx.doi.org/10.1515/dmpt-2018-0032DOI Listing
February 2019
3 Reads

Toxicity evaluation of monodisperse PEGylated magnetic nanoparticles for nanomedicine.

Nanotoxicology 2019 Feb 1:1-17. Epub 2019 Feb 1.

a Institute of Macromolecular Chemistry, Czech Academy of Sciences , Prague , Czech Republic.

Innovative nanotechnology aims to develop particles that are small, monodisperse, smart, and do not cause unintentional side effects. Uniform magnetic FeO nanoparticles (12 nm in size) were prepared by thermal decomposition of iron(III) oleate. To make them colloidally stable and dispersible in water and cell culture medium, they were modified with phosphonic acid- (PA) and hydroxamic acid (HA)-terminated poly(ethylene glycol) yielding PA-PEG@FeO and HA-PEG@FeO nanoparticles; conventional γ-FeO particles were prepared as a control. Read More

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https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1
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http://dx.doi.org/10.1080/17435390.2018.1555624DOI Listing
February 2019
3 Reads

Improved Outcome with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension.

J Neurotrauma 2019 Feb 1. Epub 2019 Feb 1.

Texas A&M University College of Medicine, 12332, Engineering Medicine, Houston, Texas, United States.

Hypotension worsens outcome after all severities of traumatic brain injury (TBI), with loss of cerebral autoregulation a potential contributor. Previously, we demonstrated that intravenous injection of a high capacity catalytic antioxidant, poly(ethylene)glycol conjugated hydrophilic carbon clusters (PEG-HCCs) rapidly restored cerebral perfusion and acutely restored brain oxidative balance in a TBI model complicated by hemorrhagic hypotension without evidence of toxicity. Here, we tested whether these acute effects translated into behavioral and structural benefit. Read More

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http://dx.doi.org/10.1089/neu.2018.6027DOI Listing
February 2019
1 Read

A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy.

Biomaterials 2019 Mar 18;197:284-293. Epub 2019 Jan 18.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; University of Science and Technology of China, Hefei, 230026, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, PR China.

Despite multifunctional nanoparticles using for photothermal therapy can efficiently kill cancer cells, their further application is still hindered by the intrinsic high uptake in the reticuloendothelial system (RES) organs, causing the slow elimination from the body and potential toxicity to the body. Therefore, it is ideal to develop multifunctional nanoparticles which process the ability to effectively accumulate in tumors, while the nanoparticles can be rapidly excreted from the body via renal clearance after effective treatment. Herein, we report the multifunctional nanoparticles (FeTNPs) based on the coordination interaction of phenolic group and metal iron, which are composed of ferric iron, tannic acid (TA) and poly (glutamic acid)-graft-methoxypoly (ethylene glycol) (PLG-g-mPEG). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.025DOI Listing
March 2019
2 Reads

Starburst Diblock Polyprodrugs: Reduction-Responsive Unimolecular Micelles with High Drug Loading and Robust Micellar Stability for Programmed Delivery of Anticancer Drugs.

Biomacromolecules 2019 Feb 1. Epub 2019 Feb 1.

Institute for Clean Energy and Advanced Materials, School of Materials and Energy , Southwest University , Chongqing , 400715 , People's Republic of China.

Polymeric prodrug based on therapeutic nanomedicine has demonstrated great promise for effective tumor growth inhibition, however, the drawbacks of low drug-loading and weak micellar stability limit its application for clinical cancer therapy. Herein, a reduction-responsive starburst block copolymer prodrug CCP [β-cyclodextrin (β-CD)-PCPT-POEGMA, XX: SS or CC] has been developed for cancer therapy. And CCP is composed of β-CD-Br core with multiple reactive sites, as well as a diblock copolymer containing hydrophobic polymerized camptothecin (PCPT) prodrug chain and hydrophilic poly[(ethylene glycol) methyl ether methacrylate] (OEGMA) chain. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01566DOI Listing
February 2019
5 Reads

Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents.

Pharm Dev Technol 2019 Jan 18:1-36. Epub 2019 Jan 18.

a Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran.

Fulfilling the purpose of developing a NP with theragnostic capabilities, the current study describes synthesis of an aptamer-functionalized PEG-coated SPION/mesoporous silica core-shell nanoparticle for concurrent cancer targeted therapy and magnetic resonance imaging. SPIONs were synthesized according to a thermal decomposition method and served as cores for SPION/mesoporous silica core/shell nanoparticles (MMSNs). Doxorubicin was then successfully loaded in MMSNs which were then coated with di-carboxylic acid functionalized poly ethylene glycol (PEG-MMSNs). Read More

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https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
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http://dx.doi.org/10.1080/10837450.2019.1569678DOI Listing
January 2019
9 Reads
1.335 Impact Factor

Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications.

ACS Appl Mater Interfaces 2019 Feb 1;11(6):6589-6604. Epub 2019 Feb 1.

Tropical Disease Laboratory, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology , University of Campinas (UNICAMP) , Campinas , São Paulo 13083-862 , Brazil.

Because of their antibacterial activity, silver nanoparticles (AgNPs) have been explored in biomedical applications. Similarly, nitric oxide (NO) is an important endogenous free radical with an antimicrobial effect and toxicity toward cancer cells that plays pivotal roles in several processes. In this work, biogenic AgNPs were prepared using green tea extract and the principles of green chemistry, and the NO donor S-nitrosoglutathione (GSNO) was prepared by the nitrosation of glutathione. Read More

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http://dx.doi.org/10.1021/acsami.8b19021DOI Listing
February 2019
2 Reads

Long-term cure of soft tissue sarcoma with pegylated-liposomal doxorubicin after doxorubicin and ifosfamide failure.

Clin Sarcoma Res 2019 15;9. Epub 2019 Jan 15.

1Department of Medicine, University of Minnesota Medical School, Office Mayo Mail Code 480, 420 Delaware St. SE, Minneapolis, MN 55455 USA.

Background: Doxorubicin is one of the most active drugs available for the treatment of sarcoma. Pegylated-liposomal doxorubicin (PLD) is a formulation of doxorubicin in which the doxorubicin is encapsulated in liposomes coated with methoxypoly (ethylene glycol); this formulation results in decreased uptake by the reticuloendothelial system, higher concentrations of drug in tumor, and less toxicity, including reduced cardiotoxicity, nausea, alopecia, and myelosuppression. No premedication is necessary. Read More

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http://dx.doi.org/10.1186/s13569-018-0111-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332634PMC
January 2019
3 Reads

Toxicity tests of cryoprotecting agents for Mytilus galloprovincialis (Lamark, 1819) early developmental stages.

Cryobiology 2019 Feb 3;86:40-46. Epub 2019 Jan 3.

Marine Biological Resources Functional Preservation Service, Estación de Ciencias Mariñas de Toralla, Universidade de Vigo, Illa de Toralla, 36331, Coruxo, Vigo, Spain. Electronic address:

Global aquaculture production of blue mussel has increased over last years. This work reaffirms the great potential of cryopreservation technique on mussel industry and overcome economic barriers a cause of a traditional and rudimentary management and continue growing. The aim of this work is to set some preliminary basis attending to toxicity of cryoprotecting agents (CPAs) on different development stages of Mytilus galloprovincialis as a start point to develop a stable cryopreservation protocol. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2019.01.001DOI Listing
February 2019
2 Reads

Tunable Properties of Poly-DL-Lactide-Monomethoxypolyethylene Glycol Porous Microparticles for Sustained Release of Polyethylenimine-DNA Polyplexes.

AAPS PharmSciTech 2019 Jan 2;20(1):23. Epub 2019 Jan 2.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S. Grand Avenue, S228 PHAR, Iowa City, Iowa, 52242, USA.

Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at therapeutic levels is challenging. Read More

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http://dx.doi.org/10.1208/s12249-018-1215-9DOI Listing
January 2019
2 Reads

Pulmonary delivery by exploiting doxorubicin and cisplatin co-loaded nanoparticles for metastatic lung cancer therapy.

J Control Release 2019 Feb 23;295:153-163. Epub 2018 Dec 23.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, PR China. Electronic address:

Despite advances in cancer therapy, effective local treatment remains a formidable challenge due to the limit of efficient drug delivery method and the toxicity of chemotherapeutics. In the current study, a combined system was developed for simultaneous delivering doxorubicin (DOX) and cis-platinum (CDDP) to the lungs via pulmonary administration. Methoxy poly(ethylene glycol)-poly(ethylenimine)-poly(l-glutamate) (mPEG-OEI-PLG) copolymers were synthesized as a carrier for the co-delivery of DOX and CDDP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183070
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http://dx.doi.org/10.1016/j.jconrel.2018.12.013DOI Listing
February 2019
7 Reads

Encapsulation of chloroquine and doxorubicin by MPEG-PLA to enhance anticancer effects by lysosomes inhibition in ovarian cancer.

Int J Nanomedicine 2018 3;13:8231-8245. Epub 2018 Dec 3.

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052, China,

Purpose: As the deadliest gynecological malignancy, ovarian cancer ranks as a major cause of disease-related deaths to women worldwide and is treated with transurethral resection or systemic chemotherapy. However, traditional chemotherapeutic drug in antitumor therapy has shown unavoidable limitations, such as poor curative effects, systemic toxicity and development of drug resistance, leading to failure of tumor inhibition and recurrence. This study aims to explore an innovative method to enhance the clinical efficiency of ovarian cancer. Read More

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http://dx.doi.org/10.2147/IJN.S174300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284531PMC
February 2019
1 Read

Enhancing the Accumulation of Polymer Micelles by Selectively Dilating Tumor Blood Vessels with NO for Highly Effective Cancer Treatment.

Adv Healthc Mater 2018 Dec 22;7(24):e1801094. Epub 2018 Nov 22.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.

The accumulation of nanoparticles in tumors by the enhanced permeability and retention (EPR) effect is effective and well known. However, how to maximize accumulation is still a bottleneck in the development of nanomedicine. Herein, a tumor vascular-targeted hybrid polymeric micelle, which has a great capacity to selectively augment the EPR effect of nanoparticles by dilating tumor blood vessels via the activity of nitric oxide (NO), is presented. Read More

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http://doi.wiley.com/10.1002/adhm.201801094
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http://dx.doi.org/10.1002/adhm.201801094DOI Listing
December 2018
2 Reads

Methotrexate-loaded biodegradable polymeric micelles for lymphoma therapy.

Int J Pharm 2019 Feb 15;557:74-85. Epub 2018 Dec 15.

Department of Hematology and Research Laboratory of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center, Chengdu 610041, PR China. Electronic address:

Drug resistance and recurrence are the main clinical challenges in chemotherapy of lymphoma. Methotrexate (MTX), especially high dose MTX (HD MTX), is extensively used to treat some aggressive subtypes of lymphoma, such as Burkitt's lymphoma, in order to overcome drug resistance. But poor solubility of the free drug and severe side effects of HD MTX limit its clinical application. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.025DOI Listing
February 2019
2 Reads

A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice.

J Biomater Appl 2019 Feb 12;33(7):946-954. Epub 2018 Dec 12.

1 School of Biological Science and Technology, University of Jinan, Jinan, China.

Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E mice. Read More

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http://dx.doi.org/10.1177/0885328218815328DOI Listing
February 2019
6 Reads

Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel.

Int J Nanomedicine 2018 19;13:7623-7631. Epub 2018 Nov 19.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China,

Background: Chemotherapy after transurethral resection is commonly recommended for bladder cancer. However, studies have shown that chemotherapy solely can hardly decrease progression rates of bladder cancer. The combination of chemotherapeutic agents with photo-dynamic therapy (PDT), a new promising localized therapy, may become a workable strategy for combating bladder cancer. Read More

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http://dx.doi.org/10.2147/IJN.S179226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251462PMC
January 2019
2 Reads

Aromatic Nitrogen Mustard-Based Autofluorescent Amphiphilic Brush Copolymer as pH-Responsive Drug Delivery Vehicle.

Biomacromolecules 2018 Dec 6. Epub 2018 Dec 6.

Delivery of clinically approved nonfluorescent drugs is facing challenges because it is difficult to monitor the intracellular drug delivery without incorporating any integrated fluorescence moiety into the drug carrier. The present investigation reports the synthesis of a pH-responsive autofluorescent polymeric nano-scaffold for the administration of nonfluorescent aromatic nitrogen mustard chlorambucil (CBL) drug into the cancer cells. Copolymerization of poly(ethylene glycol) (PEG) appended styrene and CBL conjugated N-substituted maleimide monomers enables the formation of well-defined luminescent alternating copolymer. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01468
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http://dx.doi.org/10.1021/acs.biomac.8b01468DOI Listing
December 2018
10 Reads

Phase behavior of main-chain liquid crystalline polymer networks synthesized by alkyne-azide cycloaddition chemistry.

Soft Matter 2018 Dec;14(48):9885-9900

Chemical and Biomolecular Engineering, University of Connecticut, 191 Auditorium Road Unit 3222, Storrs, CT 06269-3222, USA.

Liquid crystalline polymer networks (LCNs) couple polymer chain organization to molecular ordering, the switching of which has been shown to impart stimuli-responsive properties, including actuation and one-way shape memory, to the networks. While LCNs have long been proposed as artificial muscles, recent reports have also suggested potential as dynamic biomaterial substrates. In contrast to many existing LCNs synthesized using hydrophobic spacers, this work investigates networks synthesized using more hydrophilic spacers to promote interaction with water. Read More

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http://xlink.rsc.org/?DOI=C8SM01913D
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http://dx.doi.org/10.1039/c8sm01913dDOI Listing
December 2018
14 Reads

New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

Int J Pharm 2019 Jan 27;555:404-419. Epub 2018 Nov 27.

Ludwig Maximilian University Munich, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5, Building B, 81377 München, Germany.

The increasing application of Single-Use Systems (SUSs) in pharmaceutical manufacturing lines poses a potential risk of polymer-related impurities leaching into the process stream and persisting through the manufacturing process. To minimize any potential toxicity and impairment to the product's quality, safety thresholds are strictly regulated and enforced in particular for parenteral solutions. At present, impurities are estimated from extractable profiles, which are generated for each SUS with thermal or static extraction. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.11.033DOI Listing
January 2019
13 Reads

Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer.

Int J Nanomedicine 2018 31;13:6961-6986. Epub 2018 Oct 31.

Materials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, TX,

Introduction: Despite significant progress in the field of oncology, cancer remains one of the leading causes of death. Chemotherapy is one of the most common treatment options for cancer patients but is well known to result in off-target toxicity. Theranostic nanomedicines that integrate diagnostic and therapeutic functions within an all-in-one platform can increase tumor selectivity for more effective chemotherapy and aid in diagnosis and monitoring of therapeutic responses. Read More

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http://dx.doi.org/10.2147/IJN.S174068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217908PMC
December 2018
16 Reads

Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B.

Carbohydr Polym 2019 Feb 29;205:571-580. Epub 2018 Oct 29.

School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China. Electronic address:

Introduction of linolenic acid (LNA) and methoxy poly (ethylene glycol) (MPEG) to the backbone of oligochitosan (CS) afforded LNA-modified MPEG-CS conjugate (MPEG-CS-LNA). Amphotericin B-loaded MPEG-CS-LNA micelles (AmB-M) were prepared via dialysis method with 82.27 ± 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183128
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http://dx.doi.org/10.1016/j.carbpol.2018.10.086DOI Listing
February 2019
6 Reads

Evaluation of intraductal delivery of poly(ethylene glycol)-doxorubicin conjugate nanocarriers for the treatment of ductal carcinoma in situ (DCIS)-like lesions in rats.

J Interdiscip Nanomed 2018 Sep 15;3(3):146-159. Epub 2018 Oct 15.

Department of Pharmaceutics, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey 160 Frelinghuysen Rd. Piscataway New Jersey 08854 USA.

Ductal carcinoma in situ is the most commonly diagnosed early stage breast cancer. The efficacy of intraductally delivered poly(ethylene glycol)-doxorubicin (PEG-DOX) nanocarriers, composed of one or more DOX conjugated to various PEG polymers, was investigated in an orthotopic ductal carcinoma in situ-like rat model. In vitro cytotoxicity was evaluated against 13762 Mat B III cells using MTT assay. Read More

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http://doi.wiley.com/10.1002/jin2.51
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http://dx.doi.org/10.1002/jin2.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220801PMC
September 2018
19 Reads

Polyion complexes of a cationic antimicrobial peptide as a potential systemically administered antibiotic.

Int J Pharm 2019 Jan 13;554:284-291. Epub 2018 Nov 13.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China. Electronic address:

Antimicrobial peptides (AMPs) are regarded as next-generation antibiotics to replace conventional antibiotics due to their rapid and broad-spectrum antimicrobial properties and far less sensitivity to the development of pathogen resistance. However, they are susceptible to proteolysis in vivo by endogenous or bacterial proteases as well as induce the lysis of red blood cells, which prevent their intravenous applications. In this work, polyion complex (PIC) micelles of the cationic AMP MSI-78 and the anionic copolymer methoxy poly(ethylene glycol)-b-poly(α-glutamic acid) (mPEG-b-PGlu) were prepared to develop novel antimicrobial agents for potential application in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183084
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http://dx.doi.org/10.1016/j.ijpharm.2018.11.029DOI Listing
January 2019
9 Reads
3.650 Impact Factor

Polypeptides Micelles Composed of Methoxy-Poly(Ethylene Glycol)-Poly(l-Glutamic Acid)-Poly(l-Phenylalanine) Triblock Polymer for Sustained Drug Delivery.

Pharmaceutics 2018 Nov 13;10(4). Epub 2018 Nov 13.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing 100029, China.

Methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine) triblock polymers with different architecture were synthesized as drug carrier to obtain sustained and controlled release by tuning the composition. These triblock polymers were prepared by ring opening polymerization and poly(ethylene glycol) was used as an initiator. Polymerization was confirmed by ¹H NMR, FT-IR and gel penetration chromatography. Read More

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http://dx.doi.org/10.3390/pharmaceutics10040230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321009PMC
November 2018
1 Read

Fabrication and biological imaging of hydrazine hydrate cross-linked AIE-active fluorescent polymeric nanoparticles.

Mater Sci Eng C Mater Biol Appl 2019 Jan 12;94:310-317. Epub 2018 Sep 12.

Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, China; Department of Chemistry, Center for Nanotechnology, Institute of Biomedical Technology, Chung-Yuan Christian University, Chung-Li 32023, Taiwan. Electronic address:

Amphiphilic copolymers play a paramount role in the fabrication of fluorescent polymeric nanoparticles (FPNs) through the self-assembly procedure. In this work, novel hydrazine hydrate cross-linked amphiphilic poly(PEG‑co‑FHMA) copolymers were constructed via reversible addition-fragmentation chain transfer (RAFT) polymerization, containing an aggregation-induced emission (AIE) active hydrophobic moiety and a hydrophilic poly(ethylene glycol) (PEG) group. Different characterization techniques have been employed to confirm their successful synthesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173469
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http://dx.doi.org/10.1016/j.msec.2018.09.035DOI Listing
January 2019
12 Reads

Reversing multi-drug tumor resistance to Paclitaxel by well-defined pH-sensitive amphiphilic polypeptide block copolymers via induction of lysosomal membrane permeabilization.

Colloids Surf B Biointerfaces 2019 Feb 26;174:17-27. Epub 2018 Oct 26.

Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

A series of hybrid di-block copolymers of poly(l- glutamic acid-b-l- leucine) (PGA-PLeu), methoxy poly (ethylene glycol)-b-poly(l-leucine) (PEG-PLeu), methoxy poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamic acid) (PEG-PBLG) and tri-block copolymers of poly(ethylene glycol)-b-poly(l-glutamic acid-co-nullleucine) (PEG-PGA-PLeu) were synthesized through sequential HMDS-mediated ring-opening polymerization (ROP). Chemical structure of copolymers was studied by FTIR and H-NMR and their molecular weight was determined by H-NMR and gel permeation chromatography (GPC). Copolymers self-assembled into nanomicelles with particle size (PS) of 65 to 139 nm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765183076
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http://dx.doi.org/10.1016/j.colsurfb.2018.10.072DOI Listing
February 2019
9 Reads

Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation.

Toxicol Pathol 2018 Nov 8:192623318810199. Epub 2018 Nov 8.

1 Faculty of Biotechnology and Food Engineering, Technion, Haifa, Israel.

Thermoresponsive materials have the ability to respond to a small change in temperature-a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Read More

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http://dx.doi.org/10.1177/0192623318810199DOI Listing
November 2018
12 Reads

Extending the Scope of "Living" Crystallization-Driven Self Assembly: Well-Defined 1D Micelles and Block Comicelles from Crystallizable Polycarbonate Block Copolymers.

J Am Chem Soc 2018 Nov 4. Epub 2018 Nov 4.

Fiber-like block copolymer (BCP) micelles offer considerable potential for a variety of applications, however, uniform sam-ples of controlled length and with spatially tailored chemistry have not been accessible. Recently, a seeded growth method, termed 'living' crystallization-driven self-assembly (CDSA), has been developed to allow the formation of 1D micelles and block comicelles of precisely controlled dimensions from BCPs with a crystallizable segment. An expansion of the range of core forming blocks that participate in living CDSA is necessary for this technique to be compatible with a broad range of applications. Read More

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http://dx.doi.org/10.1021/jacs.8b09861DOI Listing
November 2018
2 Reads

Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy.

ACS Appl Mater Interfaces 2018 Nov 9;10(46):39455-39467. Epub 2018 Nov 9.

Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, School of Pharmacy , Fudan University , Shanghai 200032 , China.

Efficient drug accumulation in tumor cells is essential for cancer therapy. Herein, we developed dimeric prodrug self-delivery nanoparticles (NPs) with enhanced drug loading and bioreduction responsiveness for triple negative breast cancer (TNBC) therapy. Specially designed camptothecin dimeric prodrug (CPTD) containing a disulfide bond was constructed to realize intracellular redox potential controlled drug release. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b09730
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http://dx.doi.org/10.1021/acsami.8b09730DOI Listing
November 2018
20 Reads

Acid-active supramolecular anticancer nanoparticles based on cyclodextrin polyrotaxanes damaging both mitochondria and nuclei of tumor cells.

Biomater Sci 2018 Nov;6(12):3126-3138

Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P. R. China.

As a supramolecular macrocyclic polymer, cyclodextrin (CD) polyrotaxanes (PRs) have many advantages for developing nanomedicines, such as stable chemical composition, abundant functionalized hydroxyl groups, moving across biological barriers, adjustable nanoparticle size and good biocompatibility. Herein, we synthesized a class of acid-active therapeutic nanoparticles comprising a α-CD-based PR polymeric prodrug of PRs-poly(doxorubicin)-co-poly[(ethylene glycol) methyl ether methacrylate] (PR-PDOX-co-POEGMA, denoted as PRMO@DOX) to reduce drug leakage and selectively deliver drugs into tumor cells, aiming to achieve maximal treatment efficacy of supramolecular therapeutics. The obtained PRMO@DOX showed desirable features of high drug loading rates (>25 wt%), fast cellular uptake, acid-active controlled release, effective anti-tumor activity and low systemic toxicity. Read More

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http://xlink.rsc.org/?DOI=C8BM01020J
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http://dx.doi.org/10.1039/c8bm01020jDOI Listing
November 2018
12 Reads

Poly(ethylene glycol) induces cell toxicity in melanoma cells by producing a hyperosmotic extracellular medium.

J Biomater Appl 2018 Nov 25;33(5):693-706. Epub 2018 Oct 25.

McMaster University, Hamilton, Ontario, Canada.

Poly(ethylene glycol) is a polymer that is widely used as a biomaterial and has been approved in a host of applications. While generally viewed as inert, recent studies with poly(ethylene glycol) suggest that it may have some effects on cells and tissues, making it potentially attractive as a therapeutic agent. In this study, the effect of poly(ethylene glycol) on the cell viability, membrane transport and apoptotic markers of metastatic melanoma cells was examined. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218807675
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http://dx.doi.org/10.1177/0885328218807675DOI Listing
November 2018
15 Reads

Metalloporphyrin-indomethacin conjugates as new photosensitizers for photodynamic therapy.

J Biol Inorg Chem 2018 Oct 22. Epub 2018 Oct 22.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, People's Republic of China.

Photodynamic therapy (PDT) is a promising cancer treatment approach with the advantages of low toxicity and noninvasive characteristics. In this study, a series of metalloporphyrin-indomethacin conjugates tethered with poly(ethylene glycol) (PEG) chains were prepared and characterized. The singlet oxygen production of the conjugates was evaluated through 2', 7'-dichlorofluorescin (DCFH) method. Read More

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http://link.springer.com/10.1007/s00775-018-1626-9
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http://dx.doi.org/10.1007/s00775-018-1626-9DOI Listing
October 2018
17 Reads

Treatment of aqueous solutions of 1,4-dioxane by ozonation and catalytic ozonation with copper oxide (CuO).

Environ Technol 2018 Oct 19:1-13. Epub 2018 Oct 19.

a Department of Chemical and Food Engineering , Federal University of Santa Catarina , Florianópolis , SC , Brazil.

In this study, treatment for the removal of 1,4-dioxane by ozone and by catalytic ozonation using CuO as the catalyst was investigated. While the removal of 1,4-dioxane was small (20%) and mineralization negligible after 6 h of ozonation treatment, the removals of 1,4-dioxane and total organic carbon increased by factors of 10.35 and 81. Read More

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https://www.tandfonline.com/doi/full/10.1080/09593330.2018.1
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http://dx.doi.org/10.1080/09593330.2018.1538259DOI Listing
October 2018
6 Reads

PEGylated hydrazided gold nanorods for pH-triggered chemo/photodynamic/photothermal triple therapy of breast cancer.

Acta Biomater 2018 Dec 15;82:171-183. Epub 2018 Oct 15.

Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Integration of multimodal therapies into one nanoplatform holds great promise to overcome the drawbacks of conventional single-modal therapy and pursues enhanced anticancer efficacy. Herein, we developed a PEGylated gold nanorods (GNRs)-based nanoplatform (GNRs-MPH-PEG) with pH-responsive drug release property for triple-combined chemotherapy (CT), photodynamic therapy (PDT) and photothermal therapy (PTT) of breast cancer. GNRs were first decorated with mercaptopropionylhydrazide (MPH) and thiol-terminated monomethoxyl poly(ethylene glycol) (mPEG-SH) via Au-thiol linkage, and subsequently conjugated with chemotherapeutant doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (ALA) through acid-liable hydrazone bonds between drugs and MPH molecules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183061
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http://dx.doi.org/10.1016/j.actbio.2018.10.019DOI Listing
December 2018
10 Reads

Polylactide-Cholesterol Stereocomplex Micelle Encapsulating Chemotherapeutic Agent for Improved Antitumor Efficacy and Safety.

J Biomed Nanotechnol 2018 Dec;14(12):2102-2113

For efficient therapy, optimized polymer micelle drug delivery systems require stability during circulation, appropriate diameters for targeting, and controlled drug release at the lesion site. To enhance the stability, adjust the sizes, and improve the selectivity of drug release of micelles from polylactides and polypeptides, stereocomplex interaction has been introduced. Herein, the cholesterol (CHOL)-enhanced doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (CDM/DOX), poly(L-lactide)-based micelle (CLM/DOX), and stereocomplex micelle (SCM/DOX) from the equimolar mixture of the enantiomeric 4-armed poly(ethylene glycol)-polylactide copolymers were reported to enhance tumor cell uptake and control drug release for treatment of cervical carcinoma. Read More

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http://www.ingentaconnect.com/content/10.1166/jbn.2018.2624
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http://dx.doi.org/10.1166/jbn.2018.2624DOI Listing
December 2018
6 Reads
5.340 Impact Factor

Antibacterial Micelles with Vancomycin-Mediated Targeting and pH/Lipase-Triggered Release of Antibiotics.

ACS Appl Mater Interfaces 2018 Oct 19;10(43):36814-36823. Epub 2018 Oct 19.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering , Southwest Jiaotong University , Chengdu 610031 , P. R. China.

Antibiotic delivery systems play an important role in increasing the efficacy while reducing the off-target toxicity and antibiotic resistance. Though bacterial infections share pathophysiological pathways similar to tumor tissues, few delivery systems have achieved bacterial targeting and on-demand release of antibiotics. In the current study, amphiphilic poly(ethylene glycol)-poly(ε-caprolactone) (PECL) copolymers are conjugated with vancomycin (VAN) as targeting ligands via pH-cleavable hydrazone bonds to obtain micelle carriers (Van-hyd-PECL). Read More

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http://dx.doi.org/10.1021/acsami.8b16092DOI Listing
October 2018
3 Reads

Smart pH responsive drug delivery system based on poly(HEMA-co-DMAEMA) nanohydrogel.

Int J Pharm 2018 Dec 3;552(1-2):301-311. Epub 2018 Oct 3.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

The advent of smart nanohydrogel has revealed new opportunities for scientists to develop the most efficient anti-cancer vehicles with safe and biocompatible profile. In this experiment, using reversible addition-fragmentation chain transfer polymerization method as a novel, safe and smart pH responsive formulation of poly (hydroxyethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) and poly (ethylene glycol)-diacrylate as cross-linker were synthesized. The synthesized structure was confirmed by Fourier-transform infrared spectroscopy and proton nuclear magnetic resonance methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183073
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http://dx.doi.org/10.1016/j.ijpharm.2018.10.001DOI Listing
December 2018
8 Reads

Poly(ethylene glycol)-poly-l-glutamate complexed with polyethyleneimine-polyglycine for highly efficient gene delivery in vitro and in vivo.

Biomater Sci 2018 Nov 5;6(11):3053-3062. Epub 2018 Oct 5.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, China.

To improve gene transfection efficiency in vitro and in vivo, we first grafted polyglycine (PGly) onto branched polyethyleneimine (PEI) (molecular weight M 25 kDa) to obtain a novel gene vector PGly-PEI (PPG), before complexing it with poly(ethylene glycol)-poly-l-glutamate (PEG-PLG) for adjusting the charge density of PEI. We named the resulting nano-polyplex PG/PPG. The PPGs demonstrated improved gene transfection efficiency after grafting with polyglycine, and the efficiency could be further increased with the introduction of PEG-PLG. Read More

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http://xlink.rsc.org/?DOI=C8BM00503F
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http://dx.doi.org/10.1039/c8bm00503fDOI Listing
November 2018
3 Reads

Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices.

Int J Pharm 2018 Dec 27;552(1-2):217-224. Epub 2018 Sep 27.

Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, United States; Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, United States; Department of Biomedical Engineering, College of Engineering, The University of Iowa, United States. Electronic address:

Controlled drug delivery systems have been utilized to enhance the therapeutic effects of many drugs by delivering drugs in a time-dependent and sustained manner. Here, with the aid of 3D printing technology, drug delivery devices were fabricated and tested using a model drug (fluorophore: rhodamine B). Poly(ethylene glycol) dimethacrylate (PEGDMA) devices were fabricated using a two-photon polymerization (TPP) system and rhodamine B was homogenously entrapped inside the polymer matrix during photopolymerization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183072
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http://dx.doi.org/10.1016/j.ijpharm.2018.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204107PMC
December 2018
10 Reads

Preparation and in vivo biocompatibility studies of different mesoporous bioactive glasses.

J Mech Behav Biomed Mater 2019 Jan 17;89:89-98. Epub 2018 Sep 17.

Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India. Electronic address:

A new generation of nanostructured glasses called mesoporous bioactive glasses (MBGs) exhibit superior surface texture, porosity and bioactive characteristics. The present study is carried out to develop and detailed characterize of ternary SiO-CaO-PO MBG structure, fabricated by three different variations using different surfactants, e.g. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.09.024DOI Listing
January 2019
11 Reads

Amphiphilic block copolymers in drug delivery: advances in formulation structure and performance.

Expert Opin Drug Deliv 2018 Nov 8;15(11):1085-1104. Epub 2018 Oct 8.

a Department of Chemical and Biological Engineering , University at Buffalo, The State University of New York (SUNY) , Buffalo , NY , USA.

Introduction: Nanostructured delivery vehicles can address key challenges facing drug delivery, including the lipophilic nature of therapeutic compounds and their effective transport through the body. Amphiphilic block copolymers that self-assemble offer advantages compared with homopolymer-, lipid-, and protein-based delivery vehicles. Poly(ethylene oxide)-poly(propylene oxide) amphiphilic block copolymers (Poloxamers) serve well as pharmaceutical excipients because of their highly tunable association properties, low toxicity, and ability to functionalize. Read More

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http://dx.doi.org/10.1080/17425247.2018.1529756DOI Listing
November 2018
11 Reads

Encapsulation of verapamil and doxorubicin by MPEG-PLA to reverse drug resistance in ovarian cancer.

Biomed Pharmacother 2018 Dec 20;108:565-573. Epub 2018 Sep 20.

Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, China. Electronic address:

Purpose: Ovarian cancer is usually treated with transurethral resection or systemic chemotherapy in clinic. However, the development of drug resistance in ovarian cancer is frequently observed in ovarian cancer patients, leading to failure of tumor inhibition and recurrence. In this study, we aimed to efficiently reverse the drug resistance and enhance the anticancer effects by co-delivery of chemotherapeutic agents and multi-drugs resistant proteins inhibitor in ovarian cancer treatment. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.09.039DOI Listing
December 2018
9 Reads

The antagonist and synergist potential of cholinium-based deep eutectic solvents.

Ecotoxicol Environ Saf 2018 Dec 17;165:597-602. Epub 2018 Sep 17.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

The design of environmentally friendlier solvents has gained increasing relevance in the last decade. Deep eutectic solvents (DES) have recently emerged, with advantages like low-cost and putative lower environmental impact. However, information about DES toxicity is still scarce. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.09.027DOI Listing
December 2018
8 Reads

Combined Adsorption and Covalent Linking of Paclitaxel on Functionalized Nano-Graphene Oxide for Inhibiting Cancer Cells.

ACS Omega 2018 Feb 27;3(2):2396-2405. Epub 2018 Feb 27.

State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, No. 5 Xinmofan Road, Nanjing 210009, China.

Developing targeted delivery nanosystems for delivering chemotherapeutic anticancer drugs specifically to cancerous tissues with improvement in the specificity of drugs for different cancer cells can result in high therapeutic efficacy and low toxicity in healthy tissues. Herein, we proposed the synthesis of a multifunctional nanodelivery system, folic acid (FA) decorating nanographene oxide (nGO) functionalized with poly(ethylene glycol) (PEG), called pGO-FA, with good biocompatibility and good delivering performance of a hydrophobic water-insoluble anticancer drug of paclitaxel (PTX). 4-br-PEG-NH, FA, and PTX were attached to PEG-functionalized nGO (pGO) through a combined chemical and physical force to form a nanosized complex, pGO-FA-PTX, defined as the nanodrug system. Read More

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http://dx.doi.org/10.1021/acsomega.7b02022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130789PMC
February 2018
2 Reads

Synthesis And In Vitro/In Vivo Characterization Of Raloxifene Grafted Poly(Styrene Maleic Acid)-Poly (Amide-Ether-Ester-Imide¬¬) Micelles For Targeted Delivery Of Docetaxel In G Protein-Coupled Estrogen Receptor Breast Cancer.

Anticancer Agents Med Chem 2018 Sep 5. Epub 2018 Sep 5.

Department of Pharmaceutical Chemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan. Iran.

Background: To reduce the nonspecifically distribution of chemotherapeutic agents throughout the whole body, which causes severe toxicity in normal tissues, targeting them towards a receptor overexpressed on tumor tissue, is a promising method for cancer therapy.

Objective: The aim of the present study was development of novel copolymeric micelles of raloxifene targeted styrene maleic acid-poly amide ether ester imide-poly ethylene glycol (SMA-PAEEI-PEG-RA) and loading them with docetaxel (DTX).

Methods: Successful synthesis of the targeted copolymer was confirmed by FTIR and C-NMR spectroscopy. Read More

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http://dx.doi.org/10.2174/1871520618666180905155901DOI Listing
September 2018
12 Reads