2,407 results match your criteria Toxicity Ethylene Glycol


Comparative Toxicity Study of Docetaxel and Nanoxel, a Docetaxel-Loaded Micellar Formulation Using Cultured and Blood Cells.

Toxicol Res 2019 Apr 15;35(2):201-207. Epub 2019 Apr 15.

College of Pharmacy, Dongguk University, Goyang, Korea.

Nanoxel-PM (Nanoxel) is a docetaxel-loaded methoxy-poly(ethylene glycol)--poly(D,L-lactide) (mPEG-PDLLA). This newly developed and marketed nanoformulation exhibits an improved pharmacokinetic profile, efficacy, and safety. Although the safety of Nanoxel to docetaxel as well as its bioequivalence must be clinically confirmed, all biological activities have not been examined in or studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5487/TR.2019.35.2.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467357PMC

Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release.

Pharmaceutics 2019 Apr 11;11(4). Epub 2019 Apr 11.

Advanced Research Institute for Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China.

Stimuli-responsive polymeric micelles (PMs) have shown great potential in drug delivery and controlled release in cancer chemotherapy. Herein, inspired by the features of the tumor microenvironment, we developed dual pH/redox-responsive mixed PMs which are self-assembled from two kinds of amphiphilic diblock copolymers (poly(ethylene glycol) methyl ether-b-poly(β-amino esters) (mPEG-b-PAE) and poly(ethylene glycol) methyl ether-grafted disulfide-poly(β-amino esters) (PAE-ss-mPEG)) for anticancer drug delivery and controlled release. The co-micellization of two copolymers is evaluated by measurement of critical micelle concentration (CMC) values at different ratios of the two copolymers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics11040176DOI Listing

Ultrasmall Oxygen-Deficient Bimetallic Oxide MnWO Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy.

Adv Mater 2019 Apr 12:e1900730. Epub 2019 Apr 12.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.

Sonodynamic therapy (SDT) triggered by ultrasound (US) has attracted increasing attention owing to its abilities to overcome critical limitations including low tissue-penetration depth and phototoxicity in photodynamic therapy. Herein, the design of a new type of sonosensitizer is revealed, namely, ultrasmall oxygen-deficient bimetallic oxide MnWO nanoparticles, for multimodal imaging-guided enhanced SDT against cancer. As-made MnWO nanoparticles with poly(ethylene glycol) (PEG) modification show high physiological stability and biocompatibility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201900730DOI Listing
April 2019
1 Read

Macrophages-Mediated Delivery of Small Gold Nanorods for Tumor Hypoxia Photoacoustic Imaging and Enhanced Photothermal Therapy.

ACS Appl Mater Interfaces 2019 Apr 17. Epub 2019 Apr 17.

The Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors , Shanghai Normal University , Shanghai 200234 , China.

Macrophage-mediated delivery of drugs or nanoparticles has great potential in cancer treatment because it can avoid interception by the immune system and cross the blood-vessel barriers to reach the hypoxic regions of tumors. However, macrophage-based delivery system still faces some great challenges such as low theranostics agent loading capacity and hypoxic regions tendency in vivo. Herein, small gold nanorods (AuNRs) were used as the model theranostics agent to design a macrophage-mediated delivery system with high loading quantity for tumor hypoxia photoacoustic (PA) imaging and enhanced photothermal therapy (PTT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b00495DOI Listing

Effects of Embryonic Development Stage and Cryoprotective Agents on Galleria Mellonella Embryo Cryopreservation.

Authors:
M Abidalla E Cosi

Cryo Letters 2018 Jul/Aug;39(4):255-262

CREA - Agricultural Research Council, Centre for Agrobiological and Pedological Research, Florence, Italy.

Background: The increased research use of the honeycomb pest Galleria mellonella has created the need for cryopreservation. The diverse characteristics of G. mellonella embryos at different stages may affect embryo survival upon cryopreservation due to differential dehydration, cold resistance, cryoprotectant toxicity and permeability. Read More

View Article

Download full-text PDF

Source
April 2019
2 Reads

Design, Synthesis, and Characterization of Schiff Base Bond-Linked pH-Responsive Doxorubicin Prodrug Based on Functionalized mPEG-PCL for Targeted Cancer Therapy.

Polymers (Basel) 2018 Oct 11;10(10). Epub 2018 Oct 11.

Department of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China.

The side effects of doxorubicin (DOX) extremely limit its application in the treatment of malignant tumors. Nano-sized polymeric drugs based on the acidic microenvironment of tissular- or intra- tumor have attracted ample attention because of their potential in reducing side effects. In this research, an amphiphilic diblock copolymer based on poly (ethylene glycol) (PEG) and functionalized polycaprolactone (PCL) was synthesized and utilized as the drug carrier. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym10101127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404085PMC
October 2018

Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles.

Polymers (Basel) 2019 Feb 8;11(2). Epub 2019 Feb 8.

Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Combination therapy is a promising form of treatment. In particular, co-treatment of P3 and QBP1 has been shown to enhance therapeutic effect in vivo in treating polyglutamine diseases. These peptide drugs, however, face challenges in clinical administration due to poor stability, inability to reach intracellular targets, and lack of method to co-deliver both drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym11020288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419018PMC
February 2019
2 Reads

Cytotoxic Effect of Paclitaxel and Lapatinib -Delivered in Polylactide--Poly(ethylene glycol) Micelles on HER-2-Negative Breast Cancer Cells.

Pharmaceutics 2019 Apr 6;11(4). Epub 2019 Apr 6.

School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland, Department of Biopharmacy, Jedności 8, 41-200 Sosnowiec, Poland.

To find better strategies to enhance the cytotoxic effect of paclitaxel (PTX) and lapatinib (LAP) against breast cancer cells, we analyzed the efficacy of a novel delivery system containing polylactide-co-poly(ethylene glycol) (PLA-PEG) filomicelles of over 100 nm in length and spherical micelles of approximately 20 nm in diameter. The ¹H NMR measurements confirmed the incorporation of PTX and LAP into micelles. Analysis of the drug release mechanism revealed the diffusion-controlled release of LAP and anomalous transport of PTX. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics11040169DOI Listing
April 2019
1 Read

HO-responsive nano-prodrug for podophyllotoxin delivery.

Biomater Sci 2019 Apr 8. Epub 2019 Apr 8.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.

The tumor microenvironment is different from that of normal tissue; therefore, the development of a prodrug that retains its efficacy in the tumor microenvironment can be useful in enhancing the anticancer properties of podophyllotoxin. An innovative podophyllotoxin prodrug (POD-PEG) was designed by linking podophyllotoxin to poly(ethylene glycol)(n) monomethacrylate with a H2O2-responsive oxalate ester bond. POD-PEG can self-assemble into stable nanoparticles (POD-PEG NPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9bm00344dDOI Listing

ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer.

ACS Appl Mater Interfaces 2019 Apr 12;11(16):14647-14659. Epub 2019 Apr 12.

Department of Pharmaceutical Sciences , University of Nebraska Medical Center , Omaha , Nebraska 68198 , United States.

Ineffective drug delivery and poor prognosis are two major challenges in the treatment of pancreatic ductal adenocarcinoma (PDAC). While there is significant downregulation of tumor suppressor microRNA-34a (miR-34a), which targets many oncogenes related to proliferation, apoptosis, and invasion, high expression level of Polo-like kinase 1 (PLK1) is closely associated with short survival rates of pancreatic cancer patients. Therefore, the objective is to codeliver miR-34a mimic and small molecule PLK1 inhibitor volasertib (BI6727) using poly(ethylene glycol)-poly[aspartamidoethyl( p-boronobenzyl)diethylammonium bromide] (PEG-B-PAEBEA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b02756DOI Listing
April 2019
2 Reads

A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy.

Adv Mater 2019 Mar 25:e1806444. Epub 2019 Mar 25.

Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201806444DOI Listing
March 2019
3 Reads

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase.

Toxicol Sci 2019 Mar 23. Epub 2019 Mar 23.

Department of Emergency Medicine and Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the US and many western countries. However, the only clinically approved antidote, N-acetylcysteine, has a limited therapeutic window. 4-Methylpyrazole (4MP) is an antidote for methanol and ethylene glycol poisoning, and we have recently shown that co-treatment of 4MP with APAP effectively prevents toxicity by inhibiting Cyp2E1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfz077DOI Listing
March 2019
1 Read

Oligo(Lactic Acid)-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection.

Pharm Res 2019 Mar 19;36(5):70. Epub 2019 Mar 19.

Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin, 53705-2222, USA.

Purpose: To prepare an oligo(lactic acid)-rapamycin prodrug (o(LA)-RAP)-loaded poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) micelle for injection and characterize its compatibility and performance versus a RAP-loaded PEG-b-PLA micelle for injection in vitro and in vivo.

Methods: Monodisperse o(LA) was coupled on RAP at the C-40 via DCC/DMAP chemistry, and conversion of o(LA)-RAP prodrug into RAP was characterized in vitro. Physicochemical properties of o(LA)-RAP- and RAP-loaded PEG-b-PLA micelles and their antitumor efficacies in a syngeneic 4 T1 breast tumor model were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-019-2600-0DOI Listing
March 2019
7 Reads

Novel trastuzumab-DM1 conjugate: Synthesis and bio-evaluation.

J Cell Physiol 2019 Mar 10. Epub 2019 Mar 10.

Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Antibody-drug conjugates are now of considerable interest and are recommended for the treatment of cancers. Linkers are having a crucial role in potency and efficacy of these drugs. Herein, for the first time, we have used a water-soluble poly-ethylene glycol based linker (succinimidyl-[(N-maleimido propionamido)-diethyleneglycol] [SM(PEG)2]) for lysine amide coupling of DM1 drug to trastuzumab considering evaluation of the effect of using a hydrophilic linker on physicochemical and biological properties of the resulting conjugate in comparison to the conjugate containing succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) linker, which has a relative hydrophobic nature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28453DOI Listing
March 2019
1 Read

A Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft.

Pharm Res 2019 Mar 8;36(4):61. Epub 2019 Mar 8.

Department of Chemistry and Chemical Biology Centre, The University of Hong Kong, Pokfulam, Hong Kong.

Purpose: Interpenetrating network system (IPN), consisting of polyethylene glycol (PEG) -diacrylate (PEGdA) and modified gelatin, is a biocompatible and biodegradable hydrogel and has been studied for the local delivery of bioactive molecules and drugs. Gold(III) porphyrin(AuP) is a stable metal compound in the development for anticancer application when administered systemically. The aim of this work is to develop a novel formulation for AuP based on IPN for local delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-019-2581-zDOI Listing
March 2019
1 Read

Cytotoxicity profiling of deep eutectic solvents to human skin cells.

Sci Rep 2019 Mar 8;9(1):3932. Epub 2019 Mar 8.

Department of Biology & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal.

The tailor-made character of deep eutectic solvents (DES) turns them very attractive to be used in several applications, including in health-related areas such as pharmaceutical, nutraceutical, and cosmetic industries. However, although DES has been touted as "green" solvents, several works proved that their potential toxicity should not be neglected. Using the premise of DES applicability in the cosmetic and pharmaceutical sectors, we chose two cell lines to work as a skin model (keratinocytes HaCaT and tumor melanocytes MNT-1), to assess DES cytotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-39910-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408470PMC
March 2019
1 Read

The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome.

Biomater Sci 2019 Apr;7(5):1888-1897

Department of Biomedical Engineering, Vanderbilt University, USA.

Inefficient cytosolic delivery has limited the development of many promising biomacromolecular drugs, a long-standing challenge that has prompted extensive development of drug carriers that facilitate endosomal escape. Although many such carriers have shown considerable promise for cytosolic delivery of a diversity of therapeutics, the rupture or destabilization of endo/lysosomal membranes has also been associated with activation of the inflammasome with attendant risk of inflammation and toxicity. In this study, we investigated relationships between pH-dependent membrane destabilization, cytosolic drug delivery, and inflammasome activation using a series of well-defined poly[(ethylene glycol)-block-[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)] copolymers of variable second block composition and pH-responsive properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8bm01643gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478565PMC
April 2019
2 Reads

Thermosensitive Micelles Encapsulating Phenylalanine Ammonia Lyase Act as a Sustained and Efficacious Therapy Against Colorectal Cancer.

J Biomed Nanotechnol 2019 Apr;15(4):717-727

Colorectal cancer has become the third most commonly diagnosed cancer worldwide, which has posed challenges to current conventional therapies. Hence, we propose an alternative approach to the existing therapeutics for colorectal cancer treatment. In this work, we prepared thermosensitive micelles based on poly(ethylene glycol)-poly(caprolactone)poly(ethylene glycol) (PEG-PCL-PEG, PECE) copolymers (PAL-micelles) that were used to encapsulate phenylalanine ammonia lyase (PAL) as an sustained drug delivery system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1166/jbn.2019.2734DOI Listing
April 2019
1 Read
5.338 Impact Factor

Sub-Acute Toxicity Study of Ethylene Glycol Monomethyl Ether on the Antioxidant Defense System of the Testes and Epididymes of Wistar Rats.

Niger J Physiol Sci 2018 Dec 30;33(2):195-200. Epub 2018 Dec 30.

Department of Biochemistry, University of Ibadan, Ibadan.

Ethylene glycol monomethyl ether is a toxicant with wide industrial applications. This study is aimed atinvestigating its effect on the antioxidant system of the reproductive organs of male rats. Fifty male Wistar rats weredistributed into five groups. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read

Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid.

Drug Deliv Transl Res 2019 Mar 1. Epub 2019 Mar 1.

Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14174, Iran.

Diabetes mellitus is a chronic metabolic disorder characterized by insulin deficiency and impaired glucose metabolism. Overexpression of cAMP response element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) plays an important role in high gluconeogenesis in patients with diabetes type II. Using RNA interference technology for silencing CRTC2 gene expression could be helpful in controlling the level of blood glucose and gluconeogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13346-019-00618-1DOI Listing

Preparation of a star-shaped copolymer with porphyrin core and four PNIPAM-b-POEGMA arms for photodynamic therapy.

Mater Sci Eng C Mater Biol Appl 2019 May 28;98:74-82. Epub 2018 Dec 28.

School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China. Electronic address:

A series of thermosensitive star-shaped copolymers THPP-(PNIPAM-b-POEGMA) with 5, 10, 15,20-tetrakis-(4-hydroxyphenyl)-21H,23H-porphyrin (THPP) core and four poly(N-isopropy-lacrylamide)-b-poly(oligo(ethylene glycol) mono methyl ether methacrylate) (PNIPAM-b-POEGMA) arms were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The low critical solution temperatures (LCSTs) of THPP-(PNIPAM-b-POEGMA) with different molecular weights were 37.5 °C, 39. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2018.12.121DOI Listing
May 2019
2 Reads

Slow-release lubrication effect of graphene oxide/poly(ethylene glycol) wrapped in chitosan/sodium glycerophosphate hydrogel applied on artificial joints.

Mater Sci Eng C Mater Biol Appl 2019 May 30;98:452-460. Epub 2018 Dec 30.

Department of Orthopadics, The Second Affiliated hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China.

The artificial joints would go through serious wear after implantation surgery due to the poor lubrication of the body fluid, and the biomimetic lubricants directly injected in vitro is easy to be absorbed by human tissues, and after a period of time, it will lose its lubrication effect. However, the composite hydrogel with slow-release lubrication effect provides a new way for the lubrication of artificial joints. In this study, Graphene oxide/Poly(ethylene glycol) (GO/PEG) composites were prepared to improve the artificial joint lubrication, and through wrapped in the Chitosan/Sodium glycerophosphate (CS/GP) hydrogel, the GO/PEG lubricant will be released under the squeezing action, thus to prolong the service time of biomimetic lubricants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2018.12.109DOI Listing
May 2019
8 Reads
3.088 Impact Factor

Poly(ethylene glycol)-block-poly(d,l-lactic acid) micelles containing oligo(lactic acid)-paclitaxel prodrug: In Vivo conversion and antitumor efficacy.

J Control Release 2019 Mar 18;298:186-193. Epub 2019 Feb 18.

Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705-2222, USA. Electronic address:

Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles affect drug solubilization, and a paclitaxel (PTX) loaded-PEG-b-PLA micelle (PTX-PM) is approved for cancer treatment due to injection safety and dose escalation (Genexol-PM®) compared to Taxol®. However, PTX-PM is unstable in blood, has rapid clearance, and causes dose-limiting toxicity. We have synthesized a prodrug for PTX (7-OH), using oligo(lactic acid) as a novel pro-moiety (o(LA)-PTX) specifically for PEG-b-PLA micelles, gaining higher loading and slower release of o(LA)-PTX over PTX. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2019.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466635PMC
March 2019
2 Reads
7.705 Impact Factor

Dual micelles-loaded gelatin nanofibers and their application in lipopolysaccharide-induced periodontal disease.

Int J Nanomedicine 2019 4;14:963-976. Epub 2019 Feb 4.

Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China,

Introduction: Combined therapies utilizing inhibitors to remove pathogens are needed to suppress lipopolysaccharide (LPS)-induced periodontal disease. We prepared a novel, multi-agent delivery scaffold for periodontal treatment.

Methods: In this study, we synthesized SP600125 (a JNK inhibitor) and SB203580 (a p38 inhibitor) drug-loaded poly(ethylene glycol)-block-caprolactone copolymer via dialysis method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S182073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368126PMC
March 2019
1 Read

Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether.

Toxicol Sci 2019 Feb 15. Epub 2019 Feb 15.

Brown University, Providence, RI, USA.

Testicular histology and semen parameters are considered the gold standards when determining male reproductive toxicity. Ethylene glycol monomethyl ether (EGME) is a testicular toxicant with well-described effects on histopathology and sperm parameters. To compare the predictivity and sensitivity of molecular biomarkers of testicular toxicity to the traditional endpoints, small RNAs in the sperm were analyzed by next generation RNA-sequencing (RNA-seq). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfz041DOI Listing
February 2019
1 Read

Endoplasmic reticulum-targeted phototherapy using one-step synthesized trace metal-doped carbon-dominated nanoparticles: Laser-triggered nucleolar delivery and increased tumor accumulation.

Acta Biomater 2019 Apr 5;88:462-476. Epub 2019 Feb 5.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, Jiangsu, PR China. Electronic address:

Lysosomal entrapment and liver accumulation are the two main obstacles faced by many anticancer drugs for achieving satisfactory therapeutic outcomes. Here, we develop a facile one-step hydrothermal synthetic route to prepare trace metal (M)-, N-, and O-doped carbon-dominated nanoparticles (termed as MNOCNPs, M = Ni, Pd, or Cu, metal content: <0.1 mol%) with exceptional photothermal properties (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2019.02.005DOI Listing
April 2019
3 Reads

pH-Responsive polymeric nanocarriers for efficient killing of cariogenic bacteria in biofilms.

Biomater Sci 2019 Mar;7(4):1643-1651

College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China.

Traditional antibacterial treatments, such as chlorhexidine (CHX), destroy cariogenic biofilms. However, they exert negative effects in clinical applications, for example, teeth staining, taste disturbance and harm to oral tissue after a long-term exposure. Therefore, biocompatible strategies for efficient antibacterial drug delivery are in high demand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8bm01640bDOI Listing
March 2019
2 Reads

Gold Nanorods-Based Smart Nanoplatforms for Synergic Thermotherapy and Chemotherapy of Tumor Metastasis.

ACS Appl Mater Interfaces 2019 Feb 15;11(8):7800-7811. Epub 2019 Feb 15.

Department of Radiology, Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School , No. 321 Zhongshan Road , Nanjing 210008 , China.

The combination therapy of photothermal therapy and chemotherapy as a promising strategy has drawn extensive attention by overcoming the limitations of conventional treatments in tumor therapy. Gold nanorods-based nanoplatforms were herein designed by integrating doxorubicin (DOX)- and polydopamine-coated gold nanorods (GNRs@PDA) for tumor metastasis inhibition and multifunctional drug delivery. The GNRs@PDA-poly(ethylene glycol) (PEG)-DOX nanocomplex showed robust stability and excellent near-infrared (NIR) photothermal conversion efficiency under laser irradiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.8b21784DOI Listing
February 2019
4 Reads

Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles.

Drug Metab Pers Ther 2019 02 1;34(1). Epub 2019 Feb 1.

Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan, Iran.

Considerable development in the application of injectable drug delivery systems for cancer therapy has occurred in the last few decades. These improvements include liposomes, lipid nanoparticles (LNPs), and other nanoparticles with or without macromolecular conjugates. For example, liposomal doxorubicin modified by poly(ethylene glycol) (Doxil) was the first liposome with anti-cancer effects which was approved by the US Food and Drug Administration, whereas Abraxane (modified albumin nanoparticles loaded by paclitaxel) was recently confirmed for the treatment of breast cancer. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/dmdi.ahead-of-print/dmpt-201
Publisher Site
http://dx.doi.org/10.1515/dmpt-2018-0032DOI Listing
February 2019
4 Reads

Toxicity evaluation of monodisperse PEGylated magnetic nanoparticles for nanomedicine.

Nanotoxicology 2019 Feb 1:1-17. Epub 2019 Feb 1.

a Institute of Macromolecular Chemistry, Czech Academy of Sciences , Prague , Czech Republic.

Innovative nanotechnology aims to develop particles that are small, monodisperse, smart, and do not cause unintentional side effects. Uniform magnetic FeO nanoparticles (12 nm in size) were prepared by thermal decomposition of iron(III) oleate. To make them colloidally stable and dispersible in water and cell culture medium, they were modified with phosphonic acid- (PA) and hydroxamic acid (HA)-terminated poly(ethylene glycol) yielding PA-PEG@FeO and HA-PEG@FeO nanoparticles; conventional γ-FeO particles were prepared as a control. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1
Publisher Site
http://dx.doi.org/10.1080/17435390.2018.1555624DOI Listing
February 2019
16 Reads

Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation.

J Neurotrauma 2019 Mar 13. Epub 2019 Mar 13.

2 Department of Chemistry, Rice University, Houston, Texas.

Hypotension worsens outcome after all severities of traumatic brain injury (TBI), with loss of cerebral autoregulation being a potential contributor. Previously, we demonstrated that intravenous injection of a high capacity catalytic antioxidant, poly(ethylene)glycol conjugated hydrophilic carbon clusters (PEG-HCCs) rapidly restored cerebral perfusion and acutely restored brain oxidative balance in a TBI model complicated by hemorrhagic hypotension without evidence of toxicity. Here, we tested whether these acute effects translated into behavioral and structural benefit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/neu.2018.6027DOI Listing
March 2019
3 Reads

A comparison of poly-ethylene-glycol-coated and uncoated gold nanoparticle-mediated hepatotoxicity and oxidative stress in Sprague Dawley rats.

Int J Nanomedicine 2019 15;14:639-647. Epub 2019 Jan 15.

NIH-RCMI Center for Environmental Health, College of Science Engineering and Technology, Jackson State University, Jackson, MS, 39217, USA,

Background: Gold nanoparticles (GNPs) and their functional derivatives are of great interest because of their many biomedical applications. GNPs are increasingly being incorporated into new diagnostic and therapeutic approaches in medicine. Consequently, there has been a strong push to fully understand their interactions with blood components. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S185574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339646PMC
February 2019
4 Reads

A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy.

Biomaterials 2019 Mar 18;197:284-293. Epub 2019 Jan 18.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; University of Science and Technology of China, Hefei, 230026, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, PR China.

Despite multifunctional nanoparticles using for photothermal therapy can efficiently kill cancer cells, their further application is still hindered by the intrinsic high uptake in the reticuloendothelial system (RES) organs, causing the slow elimination from the body and potential toxicity to the body. Therefore, it is ideal to develop multifunctional nanoparticles which process the ability to effectively accumulate in tumors, while the nanoparticles can be rapidly excreted from the body via renal clearance after effective treatment. Herein, we report the multifunctional nanoparticles (FeTNPs) based on the coordination interaction of phenolic group and metal iron, which are composed of ferric iron, tannic acid (TA) and poly (glutamic acid)-graft-methoxypoly (ethylene glycol) (PLG-g-mPEG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2019.01.025DOI Listing
March 2019
4 Reads

Starburst Diblock Polyprodrugs: Reduction-Responsive Unimolecular Micelles with High Drug Loading and Robust Micellar Stability for Programmed Delivery of Anticancer Drugs.

Biomacromolecules 2019 Mar 1;20(3):1190-1202. Epub 2019 Feb 1.

Institute for Clean Energy and Advanced Materials, School of Materials and Energy , Southwest University , Chongqing , 400715 , People's Republic of China.

Polymeric prodrug based on therapeutic nanomedicine has demonstrated great promise for effective tumor growth inhibition, however, the drawbacks of low drug-loading and weak micellar stability limit its application for clinical cancer therapy. Herein, a reduction-responsive starburst block copolymer prodrug CCP [β-cyclodextrin (β-CD)-PCPT-POEGMA, XX: SS or CC] has been developed for cancer therapy. And CCP is composed of β-CD-Br core with multiple reactive sites, as well as a diblock copolymer containing hydrophobic polymerized camptothecin (PCPT) prodrug chain and hydrophilic poly[(ethylene glycol) methyl ether methacrylate] (OEGMA) chain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biomac.8b01566DOI Listing
March 2019
13 Reads

Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents.

Pharm Dev Technol 2019 Jan 18:1-36. Epub 2019 Jan 18.

a Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran.

Fulfilling the purpose of developing a NP with theragnostic capabilities, the current study describes synthesis of an aptamer-functionalized PEG-coated SPION/mesoporous silica core-shell nanoparticle for concurrent cancer targeted therapy and magnetic resonance imaging. SPIONs were synthesized according to a thermal decomposition method and served as cores for SPION/mesoporous silica core/shell nanoparticles (MMSNs). Doxorubicin was then successfully loaded in MMSNs which were then coated with di-carboxylic acid functionalized poly ethylene glycol (PEG-MMSNs). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1
Publisher Site
http://dx.doi.org/10.1080/10837450.2019.1569678DOI Listing
January 2019
18 Reads
1.335 Impact Factor

Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications.

ACS Appl Mater Interfaces 2019 Feb 1;11(6):6589-6604. Epub 2019 Feb 1.

Tropical Disease Laboratory, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology , University of Campinas (UNICAMP) , Campinas , São Paulo 13083-862 , Brazil.

Because of their antibacterial activity, silver nanoparticles (AgNPs) have been explored in biomedical applications. Similarly, nitric oxide (NO) is an important endogenous free radical with an antimicrobial effect and toxicity toward cancer cells that plays pivotal roles in several processes. In this work, biogenic AgNPs were prepared using green tea extract and the principles of green chemistry, and the NO donor S-nitrosoglutathione (GSNO) was prepared by the nitrosation of glutathione. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.8b19021DOI Listing
February 2019
3 Reads

Long-term cure of soft tissue sarcoma with pegylated-liposomal doxorubicin after doxorubicin and ifosfamide failure.

Clin Sarcoma Res 2019 15;9. Epub 2019 Jan 15.

1Department of Medicine, University of Minnesota Medical School, Office Mayo Mail Code 480, 420 Delaware St. SE, Minneapolis, MN 55455 USA.

Background: Doxorubicin is one of the most active drugs available for the treatment of sarcoma. Pegylated-liposomal doxorubicin (PLD) is a formulation of doxorubicin in which the doxorubicin is encapsulated in liposomes coated with methoxypoly (ethylene glycol); this formulation results in decreased uptake by the reticuloendothelial system, higher concentrations of drug in tumor, and less toxicity, including reduced cardiotoxicity, nausea, alopecia, and myelosuppression. No premedication is necessary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13569-018-0111-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332634PMC
January 2019
4 Reads

Polyethylene glycol 400 significantly enhances the stimulation of 2-phenoxyethanol on Vibrio qinghaiensis sp.-Q67 bioluminescence.

Ecotoxicol Environ Saf 2019 Apr 3;171:240-246. Epub 2019 Jan 3.

Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Previous studies demonstrated long-term stimulation of some commercial personal care products (PCPs) on freshwater luminescent bacteria Vibrio qinghaiensis sp.-Q67 (Q67). However, whether a certain component can affect mixture's hormetic effect is still unknown. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01476513183138
Publisher Site
http://dx.doi.org/10.1016/j.ecoenv.2018.12.087DOI Listing
April 2019
2 Reads

Toxicity tests of cryoprotecting agents for Mytilus galloprovincialis (Lamark, 1819) early developmental stages.

Cryobiology 2019 Feb 3;86:40-46. Epub 2019 Jan 3.

Marine Biological Resources Functional Preservation Service, Estación de Ciencias Mariñas de Toralla, Universidade de Vigo, Illa de Toralla, 36331, Coruxo, Vigo, Spain. Electronic address:

Global aquaculture production of blue mussel has increased over last years. This work reaffirms the great potential of cryopreservation technique on mussel industry and overcome economic barriers a cause of a traditional and rudimentary management and continue growing. The aim of this work is to set some preliminary basis attending to toxicity of cryoprotecting agents (CPAs) on different development stages of Mytilus galloprovincialis as a start point to develop a stable cryopreservation protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cryobiol.2019.01.001DOI Listing
February 2019
3 Reads

Tunable Properties of Poly-DL-Lactide-Monomethoxypolyethylene Glycol Porous Microparticles for Sustained Release of Polyethylenimine-DNA Polyplexes.

AAPS PharmSciTech 2019 Jan 2;20(1):23. Epub 2019 Jan 2.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S. Grand Avenue, S228 PHAR, Iowa City, Iowa, 52242, USA.

Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at therapeutic levels is challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12249-018-1215-9DOI Listing
January 2019
5 Reads

Pulmonary delivery by exploiting doxorubicin and cisplatin co-loaded nanoparticles for metastatic lung cancer therapy.

J Control Release 2019 Feb 23;295:153-163. Epub 2018 Dec 23.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, PR China. Electronic address:

Despite advances in cancer therapy, effective local treatment remains a formidable challenge due to the limit of efficient drug delivery method and the toxicity of chemotherapeutics. In the current study, a combined system was developed for simultaneous delivering doxorubicin (DOX) and cis-platinum (CDDP) to the lungs via pulmonary administration. Methoxy poly(ethylene glycol)-poly(ethylenimine)-poly(l-glutamate) (mPEG-OEI-PLG) copolymers were synthesized as a carrier for the co-delivery of DOX and CDDP. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01683659183070
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2018.12.013DOI Listing
February 2019
14 Reads

Encapsulation of chloroquine and doxorubicin by MPEG-PLA to enhance anticancer effects by lysosomes inhibition in ovarian cancer.

Int J Nanomedicine 2018 3;13:8231-8245. Epub 2018 Dec 3.

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052, China,

Purpose: As the deadliest gynecological malignancy, ovarian cancer ranks as a major cause of disease-related deaths to women worldwide and is treated with transurethral resection or systemic chemotherapy. However, traditional chemotherapeutic drug in antitumor therapy has shown unavoidable limitations, such as poor curative effects, systemic toxicity and development of drug resistance, leading to failure of tumor inhibition and recurrence. This study aims to explore an innovative method to enhance the clinical efficiency of ovarian cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S174300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284531PMC
February 2019
2 Reads

Enhancing the Accumulation of Polymer Micelles by Selectively Dilating Tumor Blood Vessels with NO for Highly Effective Cancer Treatment.

Adv Healthc Mater 2018 Dec 22;7(24):e1801094. Epub 2018 Nov 22.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China.

The accumulation of nanoparticles in tumors by the enhanced permeability and retention (EPR) effect is effective and well known. However, how to maximize accumulation is still a bottleneck in the development of nanomedicine. Herein, a tumor vascular-targeted hybrid polymeric micelle, which has a great capacity to selectively augment the EPR effect of nanoparticles by dilating tumor blood vessels via the activity of nitric oxide (NO), is presented. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/adhm.201801094
Publisher Site
http://dx.doi.org/10.1002/adhm.201801094DOI Listing
December 2018
3 Reads

Methotrexate-loaded biodegradable polymeric micelles for lymphoma therapy.

Int J Pharm 2019 Feb 15;557:74-85. Epub 2018 Dec 15.

Department of Hematology and Research Laboratory of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center, Chengdu 610041, PR China. Electronic address:

Drug resistance and recurrence are the main clinical challenges in chemotherapy of lymphoma. Methotrexate (MTX), especially high dose MTX (HD MTX), is extensively used to treat some aggressive subtypes of lymphoma, such as Burkitt's lymphoma, in order to overcome drug resistance. But poor solubility of the free drug and severe side effects of HD MTX limit its clinical application. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.12.025DOI Listing
February 2019
6 Reads

A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice.

J Biomater Appl 2019 Feb 12;33(7):946-954. Epub 2018 Dec 12.

1 School of Biological Science and Technology, University of Jinan, Jinan, China.

Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0885328218815328DOI Listing
February 2019
9 Reads

Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel.

Int J Nanomedicine 2018 19;13:7623-7631. Epub 2018 Nov 19.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China,

Background: Chemotherapy after transurethral resection is commonly recommended for bladder cancer. However, studies have shown that chemotherapy solely can hardly decrease progression rates of bladder cancer. The combination of chemotherapeutic agents with photo-dynamic therapy (PDT), a new promising localized therapy, may become a workable strategy for combating bladder cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S179226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251462PMC
January 2019
6 Reads

Aromatic Nitrogen Mustard-Based Autofluorescent Amphiphilic Brush Copolymer as pH-Responsive Drug Delivery Vehicle.

Biomacromolecules 2019 Jan 21;20(1):546-557. Epub 2018 Dec 21.

Centre for Healthcare Science and Technology , Indian Institute of Engineering Science and Technology , Shibpur - 711103 , West Bengal , India.

Delivery of clinically approved nonfluorescent drugs is facing challenges because it is difficult to monitor the intracellular drug delivery without incorporating any integrated fluorescence moiety into the drug carrier. The present investigation reports the synthesis of a pH-responsive autofluorescent polymeric nanoscaffold for the administration of nonfluorescent aromatic nitrogen mustard chlorambucil (CBL) drug into the cancer cells. Copolymerization of poly(ethylene glycol) (PEG) appended styrene and CBL conjugated N-substituted maleimide monomers enables the formation of well-defined luminescent alternating copolymer. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.biomac.8b01468
Publisher Site
http://dx.doi.org/10.1021/acs.biomac.8b01468DOI Listing
January 2019
16 Reads

Phase behavior of main-chain liquid crystalline polymer networks synthesized by alkyne-azide cycloaddition chemistry.

Soft Matter 2018 Dec;14(48):9885-9900

Chemical and Biomolecular Engineering, University of Connecticut, 191 Auditorium Road Unit 3222, Storrs, CT 06269-3222, USA.

Liquid crystalline polymer networks (LCNs) couple polymer chain organization to molecular ordering, the switching of which has been shown to impart stimuli-responsive properties, including actuation and one-way shape memory, to the networks. While LCNs have long been proposed as artificial muscles, recent reports have also suggested potential as dynamic biomaterial substrates. In contrast to many existing LCNs synthesized using hydrophobic spacers, this work investigates networks synthesized using more hydrophilic spacers to promote interaction with water. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C8SM01913D
Publisher Site
http://dx.doi.org/10.1039/c8sm01913dDOI Listing
December 2018
22 Reads

New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

Int J Pharm 2019 Jan 27;555:404-419. Epub 2018 Nov 27.

Ludwig Maximilian University Munich, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5, Building B, 81377 München, Germany.

The increasing application of Single-Use Systems (SUSs) in pharmaceutical manufacturing lines poses a potential risk of polymer-related impurities leaching into the process stream and persisting through the manufacturing process. To minimize any potential toxicity and impairment to the product's quality, safety thresholds are strictly regulated and enforced in particular for parenteral solutions. At present, impurities are estimated from extractable profiles, which are generated for each SUS with thermal or static extraction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.11.033DOI Listing
January 2019
16 Reads