2,949 results match your criteria Toxicity Ethylene Glycol


Nanodiamonds with Surface Grafted Polymer Chains as Vehicles for Cell Imaging and Cisplatin Delivery: Enhancement of Cell Toxicity by POEGMEMA Coating.

ACS Macro Lett 2013 Mar 27;2(3):246-250. Epub 2013 Feb 27.

Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South Wales, Sydney NSW 2052, Australia.

Nanodiamonds (NDs) are highly promising drug carriers due to their biocompatibility, manipulable surface chemistry, and nonbleaching flourescence. In this communication, we compare the cytotoxicity of three ND-cisplatin systems in which cisplatin was incorporated via direct attachment to the ND surface, physical adsorption within a poly(oligo(ethylene glycol) methyl ether methacrylate) POEGMEMA surface coating, or complexation to 1,1-di--butyl 3-(2-methacryloyloxy)ethyl)butane-1,1,3-tricarboxylate (MAETC) groups of a POEGMEMA--PMAETC surface layer. The polymer layers were introduced by grafting from RAFT-functionalized ND particles. Read More

View Article and Full-Text PDF

Physical Evidence of Oil Uptake and Toxicity Assessment of Amphiphilic Grafted Nanoparticles Used as Oil Dispersants.

Environ Sci Technol 2022 May 17. Epub 2022 May 17.

Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida 32611, United States.

Herein, we report the toxicity evaluation of a new prototype dispersant system, silicon dioxide nanoparticles (NPs) functionalized with (3-glycidoxypropyl)triethoxysilane (GPS) and grafted poly(ε-caprolactone)--poly[oligo(ethylene glycol)methyl methacrylate mono-methyl ether] (NP-PCL-POEGMA). This serves as a follow up of our previous study where grafted silicon dioxide NPs functionalized with GPS and grafted hyperbranched poly(glycidol) (NP-HPG) were evaluated for reducing the toxicity in embryo, juvenile, and adult fish populations. In this study, the NP-HPG sample is used as a baseline to compare against the new NP-PCL-POEGMA samples. Read More

View Article and Full-Text PDF

Osteogenesis of Iron Oxide Nanoparticles-Labeled Human Precartilaginous Stem Cells in Interpenetrating Network Printable Hydrogel.

Front Bioeng Biotechnol 2022 29;10:872149. Epub 2022 Apr 29.

School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.

Smart biomaterials combined with stem cell-based therapeutic strategies have brought innovation in the field of bone tissue regeneration. However, little is known about precartilaginous stem cells (PCSCs), which can be used as seed cells and incorporated with bioactive scaffolds for reconstructive tissue therapy of bone defects. Herein, iron oxide nanoparticles (IONPs) were employed to modulate the fate of PCSCs, resulting in the enhanced osteogenic differentiation potential both and . Read More

View Article and Full-Text PDF

Pegylation of phenothiazine - A synthetic route towards potent anticancer drugs.

J Adv Res 2022 03 9;37:279-290. Epub 2021 Jul 9.

Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.

Introduction: Cancer is a big challenge of the 21 century, whose defeat requires efficient antitumor drugs.

Objectives: The paper aims to investigate the synergistic effect of two structural building blocks, phenothiazine and poly(ethylene glycol), towards efficient antitumor drugs.

Methods: Two PEGylated phenothiazine derivatives were synthetized by attaching poly(ethylene glycol) of 550 Da to the nitrogen atom of phenothiazine by ether or ester linkage. Read More

View Article and Full-Text PDF

Hypoxia-Responsive Stereocomplex Polymeric Micelles with Improved Drug Loading Inhibit Breast Cancer Metastasis in an Orthotopic Murine Model.

ACS Appl Mater Interfaces 2022 May 27;14(18):20551-20565. Epub 2022 Apr 27.

Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226019, People's Republic of China.

Tumor metastasis is a leading cause of breast cancer-related death. Taxane-loaded polymeric formulations, such as Genexol PM and Nanoxel M using poly(ethylene glycol)-poly(d,l-lactide) (PEG-PLA) micelles as drug carriers, have been approved for the treatment of metastatic breast cancer. Unfortunately, the physical instability of PEG-PLA micelles, leading to poor drug loading, premature drug leakage, and consequently limited drug delivery to tumors, largely hinders their therapeutic outcome. Read More

View Article and Full-Text PDF

mPEG-PDLLA Micelles Potentiate Docetaxel for Intraperitoneal Chemotherapy in Ovarian Cancer Peritoneal Metastasis.

Front Pharmacol 2022 6;13:861938. Epub 2022 Apr 6.

Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Ovarian cancer is the second most common cause of gynecological cancer death in women. It is usually diagnosed late and accompanied by peritoneal metastasis. For ovarian cancer with peritoneal metastasis, intraperitoneal (IP) chemotherapy can maintain a high drug concentration in the abdominal cavity and reduce local and systemic toxicity. Read More

View Article and Full-Text PDF

Injectable Hydrogel Based on Protein-Polyester Microporous Network as an Implantable Niche for Active Cell Recruitment.

Pharmaceutics 2022 Mar 26;14(4). Epub 2022 Mar 26.

School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Gyeonggi-do, Korea.

Despite the potential of hydrogel-based localized cancer therapies, their efficacy can be limited by cancer recurrence. Therefore, it is of great significance to develop a hydrogel system that can provoke robust and durable immune response in the human body. This study has developed an injectable protein-polymer-based porous hydrogel network composed of lysozyme and poly(ε-caprolactone-co-lactide)--poly(ethylene glycol)--poly(ε-caprolactone-co-lactide (PCLA) (Lys-PCLA) bioconjugate for the active recruitment dendritic cells (DCs). Read More

View Article and Full-Text PDF

Investigating a Curcumin-Loaded PLGA-PEG-PLGA Thermo-Sensitive Hydrogel for the Prevention of Alzheimer's Disease.

Antioxidants (Basel) 2022 Apr 7;11(4). Epub 2022 Apr 7.

Institute of Biomedical Engineering, National Taiwan University, No.1, Sec. 1, Jen-Ai Road, Taipei 10617, Taiwan.

In Alzheimer's disease (AD), the most common cause of dementia, patients generally forget to take pills or skip medication due to side effects, affecting the treatment efficacy. In this study, we combined a poly(lactic-co-glycolic acid), (PLGA)-poly(ethylene glycol), and (PEG)-PLGA thermo-sensitive hydrogel with curcumin (PGC) to deliver an intramuscular injection that could continuously release curcumin and maintain it at a constant level in blood to prevent AD development or progression. We evaluated the drug release profile and cytotoxicity of PGC and its effects on AD pathology through in vitro and in vivo studies and on cognitive function through an aluminum-chloride-induced AD rat model. Read More

View Article and Full-Text PDF

Poly(4-Styrenesulfonic Acid--maleic Anhydride)-Coated NaGdF:Yb,Tb,Nd Nanoparticles with Luminescence and Magnetic Properties for Imaging of Pancreatic Islets and β-Cells.

ACS Appl Mater Interfaces 2022 Apr 13;14(16):18233-18247. Epub 2022 Apr 13.

Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovského nám. 2, Prague 6 162 06, Czech Republic.

Novel Yb,Tb,Nd-doped GdF and NaGdF nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesulfonic acid--maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb, Tb, and Nd ions in the NaGdF host nanoparticles induced luminescence under ultraviolet and near-infrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). Read More

View Article and Full-Text PDF

Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells.

Cancers (Basel) 2022 Apr 1;14(7). Epub 2022 Apr 1.

Faculty of Science, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

An efficient and selective drug delivery vehicle for cancer cells can remarkably improve therapeutic approaches. In this study, we focused on the synthesis and characterization of magnetic NiCoFeO nanoparticles (NPs) coated with two layers of methionine and polyethylene glycol to increase the loading capacity and lower toxicity to serve as an efficient drug carrier. [email protected]@PEG NPs were synthesized by a reflux method then characterized by FTIR, XRD, FESEM, TEM, and VSM. Read More

View Article and Full-Text PDF

Caging Cationic Polymer Brush-Coated Plasmonic Nanostructures for Traceable Selective Antimicrobial Activities.

Macromol Rapid Commun 2022 May 21;43(10):e2100812. Epub 2022 Apr 21.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637457, Singapore.

Cationic polymers are under intense research to achieve prominent antimicrobial activity. However, the cellular and in vivo toxicity caused by nonspecific electrostatic interaction has become a major challenge for their practical applications. Here, the development of a "caging" strategy based on the use of a block copolymer consisting of a stealth block and an anionic block that undergoes degradation in presence of enzymes secreted by selective bacterial pathogens of interest is reported. Read More

View Article and Full-Text PDF

Ibuprofen-Loaded Electrospun PCL/PEG Nanofibrous Membranes for Preventing Postoperative Abdominal Adhesion.

ACS Appl Bio Mater 2022 Apr 7;5(4):1766-1778. Epub 2022 Apr 7.

Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran 15875-4413, Iran.

Electrospun nanofibrous membranes are a widely used physical barrier for reducing postoperative adhesion. However, these physical barriers could not prevent adhesion formation completely. Because a high-intensity inflammation occurs in the surgical area, the presence of relevant drugs to control such an inflammation is desperately needed. Read More

View Article and Full-Text PDF

Nanogap-containing thermo-plasmonic nano-heaters for amplified photo-triggered tumor ablation at low laser power density.

Biomater Sci 2022 May 4;10(9):2394-2408. Epub 2022 May 4.

Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea.

Herein, nanogap amplified plasmonic heat-generators are fabricated by decorating Pt nanodots on gold nanospheres ([email protected]@mPEG) by maintaining strategic nano-gaps (1-2 nm) and studied precisely for plasmonic photothermal therapy (PPTT) of colon cancer by passive tumor targeting. The surface modification of [email protected] with poly(ethylene glycol) methyl ether thiol (mPEG) increases their accumulation in tumor cells and hence the [email protected]@mPEG stay at the tumor site for a longer time. The nanogap amplified [email protected]@mPEG (O. Read More

View Article and Full-Text PDF

Functional Ability of Dental Materials After Inclusion of Nanocarriers Containing Functional Substances: A Systematic Review.

Mini Rev Med Chem 2022 Mar 30. Epub 2022 Mar 30.

Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal - RN, Brazil.

Background: Nanocarriers are nanoparticles used to transport functional substances.

Objective: This study aimed to perform a systematic review analyzing the functional ability of dental materials after inclusion of nanocarriers containing functional substances.

Materials And Methods: We searched PubMed, Web of Science, EMBASE, SciELO, and Science Direct from (02/03/21) to (02/06/21) without restriction on the year of publication. Read More

View Article and Full-Text PDF

Development, Characterization, and Investigation of In Vivo Targeted Delivery Efficacy of Luteolin-Loaded, Eudragit S100-Coated mPEG-PLGA Nanoparticles.

AAPS PharmSciTech 2022 Mar 29;23(4):100. Epub 2022 Mar 29.

Qingdao Women and Children's Hospital, Qingdao, Shandong, China.

Luteolin (Lu) is a kind of flavonoid that has been proved to treat non-alcoholic fatty liver disease by alleviating intestinal microbiota disorder. In this study, luteolin was coated with methoxy poly(ethylene glycol)-poly(dl-lactide-co-glycolic acid) (mPEG-PLGA) using an emulsion solvent evaporation method, and the optimum preparation process was determined by a single-factor experiment combined with response surface methodology (RSM). Methacrylic acid-methyl methacrylate (1:2) copolymer (Eudragit S100) was then used to coat the surface of Lu/mPEG-PLGA nanoparticles. Read More

View Article and Full-Text PDF

In situ Co-Delivery of Doxorubicin and Cisplatin by Injectable Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment.

Int J Nanomedicine 2022 22;17:1309-1322. Epub 2022 Mar 22.

Department of Orthopedic Surgery, Qilu Hospital of Shandong University, Jinan, 250012, People's Republic of China.

Purpose: Osteosarcoma is considered as the most common primary malignant bone tumor in children and adolescents, and the treatments including chemotherapy and surgery were far from satisfactory. Localized tumor treatments by hydrogels incorporating combined chemotherapeutic drugs have recently emerged as superior approaches for enhanced anti-tumor effects and reduced systemic toxicity.

Methods: A novel injectable thermosensitive poly (lactide-co- glycolide)-poly (ethylene glycol)-poly(lactide-co-glycolide) triblock copolymer hydrogel containing doxorubicin and cisplatin for the localized chemotherapy of osteosarcoma were synthesized and characterized. Read More

View Article and Full-Text PDF

Polyaspartic acid, 2-acrylamido-2-Methyl propane sulfonic acid and sodium alginate based biocompatible stimuli responsive polymer gel for controlled release of GHK-Cu peptide for wound healing.

J Biomater Appl 2022 Mar 26:8853282221076708. Epub 2022 Mar 26.

Department of Chemistry, 28782Dyal Singh College, New Delhi, India.

Stimuli responsive polymer based on Polyaspartic acid, 2-Acrylamido-2-methylpropane sulfonic acid and sodium alginate (NaAlg) were synthesized using two cross-linkers Ethylene glycol dimethacrylate (EGDMA) and TMPTA (Trimethylolpropane triacrylate). The polymers were standardized and optimized to obtain a polymer with maximum swelling in distilled water, saline, glucose and solutions of varying pH. The synthesized polymer swelled well in distilled water, glucose solution and acidic- alkaline medium. Read More

View Article and Full-Text PDF

A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery.

Pharmaceutics 2022 Mar 9;14(3). Epub 2022 Mar 9.

Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro Seongdong-gu, Seoul 04763, Korea.

Adenoviruses (Ads) are attractive nonviral vectors and show great potential in cancer gene therapy. However, inherent properties of Ads, including immunogenicity, nonspecific toxicity, and coxsackie and adenovirus receptor (CAR)-dependent cell uptake, limit their clinical use. To surmount these issues, we developed a pH- and glutathione-responsive poly(ethylene glycol)-poly(ꞵ-aminoester)-polyethyleneimine (PPA) for conjugation with Ad. Read More

View Article and Full-Text PDF

A transistor-like pH-sensitive nanodetergent for selective cancer therapy.

Nat Nanotechnol 2022 May 24;17(5):541-551. Epub 2022 Mar 24.

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China.

Plasma membrane rupture is a promising strategy for drug-resistant cancer treatment, but its application is limited by the low tumour selectivity of membranolytic molecules. Here we report the design of 'proton transistor' nanodetergents that can convert the subtle pH perturbation signals of tumour tissues into sharp transition signals of membranolytic activity for selective cancer therapy. Our top-performing 'proton transistor' nanodetergent, P(C6-Bn), can achieve a >32-fold change in cytotoxicity with a 0. Read More

View Article and Full-Text PDF

Drug-free neutrally charged polypeptide nanoparticles as anticancer agents.

J Control Release 2022 Mar 22;345:464-474. Epub 2022 Mar 22.

Institute of Bioengineering and Bioimaging, 31 Biopolis Way, Singapore 138669, Singapore; Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119288, Singapore. Electronic address:

Cationic synthetic anticancer polymers and peptides have attracted increasing attention for advancing cancer treatment without causing drug resistance development. To circumvent in vivo instability and toxicity caused by cationic charges of the anticancer polymers/peptides, we report, for the first time, a nanoparticulate delivery system self-assembled from a negatively charged pH-sensitive polypeptide poly(ethylene glycol)-b-poly(ʟ-lysine)-graft-cyclohexene-1,2-dicarboxylic anhydride and a cationic anticancer polypeptide guanidinium-functionalized poly(ʟ-lysine) (PLL-Gua) via electrostatic interaction. The formation of nanoparticles (Gua-NPs) neutralized the positive charges of PLL-Gua. Read More

View Article and Full-Text PDF

Ethylene glycol toxicosis in milk-fed dairy calves.

Acta Vet Scand 2022 Mar 24;64(1). Epub 2022 Mar 24.

Department of Veterinary Clinical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark.

Background: Ethylene glycol (EG) (antifreeze) toxicosis has mostly been reported in dogs and cats, while reports on EG toxicosis in cattle are sparse. We report EG toxicosis in 25 milk-fed calves associated with a leak in the cooling pipes in a milk taxi. The milk taxi was connected to a geothermal heating system in which EG was used as antifreeze. Read More

View Article and Full-Text PDF

Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy.

Carbohydr Polym 2022 May 29;284:119183. Epub 2022 Jan 29.

Hubei Engineering Center of Natural Polymers-based Medical Materials, Wuhan University, Wuhan 430072, China; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China. Electronic address:

The linear β-(1, 3)-glucans from yeast (BYGs) with good biocompatibility and targetability to macrophages were used for fabricating BYG-based nanoparticles to deliver methotrexate with systemic toxicity for treatment of rheumatoid arthritis. Methoxy poly (ethylene glycol) (mPEG) was successfully grafted onto BYGs chains, followed by chemical crosslinking to get the crosslinked copolymer (cBP) with amphiphilicity, which could self-assemble into spherical nanoparticles (ca.52. Read More

View Article and Full-Text PDF

Antifreeze Proteins: Novel Applications and Navigation towards Their Clinical Application in Cryobanking.

Int J Mol Sci 2022 Feb 27;23(5). Epub 2022 Feb 27.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.

Antifreeze proteins (AFPs) or thermal hysteresis (TH) proteins are biomolecular gifts of nature to sustain life in extremely cold environments. This family of peptides, glycopeptides and proteins produced by diverse organisms including bacteria, yeast, insects and fish act by non-colligatively depressing the freezing temperature of the water below its melting point in a process termed thermal hysteresis which is then responsible for ice crystal equilibrium and inhibition of ice recrystallisation; the major cause of cell dehydration, membrane rupture and subsequent cryodamage. Scientists on the other hand have been exploring various substances as cryoprotectants. Read More

View Article and Full-Text PDF
February 2022

EGDMA- and TRIM-Based Microparticles Imprinted with 5-Fluorouracil for Prolonged Drug Delivery.

Polymers (Basel) 2022 Mar 4;14(5). Epub 2022 Mar 4.

Department of Pharmacology, Poznan University of Medical Sciences, 61-614 Poznan, Poland.

Imprinted materials possess designed cavities capable of forming selective interactions with molecules used in the imprinting process. In this work, we report the synthesis of 5-fluorouracil (5-FU)-imprinted microparticles and their application in prolonged drug delivery. The materials were synthesized using either ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) cross-linkers. Read More

View Article and Full-Text PDF

Delivery of acetogenin-enriched Annona muricata Linn leaf extract by folic acid-conjugated and triphenylphosphonium-conjugated poly(glycerol adipate) nanoparticles to enhance toxicity against ovarian cancer cells.

Int J Pharm 2022 Apr 6;618:121636. Epub 2022 Mar 6.

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. Electronic address:

The study demonstrated the fabrication of new poly(glycerol adipate) (PGA) nanoparticles decorated with folic acid (FOL-PGA) and triphenylphosphonium (TPP-PGA) and the potential on the delivery of acetogenin-enriched Annona muricata Linn leaf extract to ovarian cancer cells. FOL-PGA and TPP-PGA were successfully synthesized and used to fabricate FOL-decorated nanoparticles (FOL-NPs) and FOL-/TPP- decorated nanoparticles (FOL/TPP-NPs) by blending two polymers at a mass ratio of 1:1. All nanoparticles had small size of around 100 nm, narrow size distribution and high negative surface charge about -30 mV. Read More

View Article and Full-Text PDF

Synthesis and characterization of self-assembling chitosan-based nanoparticles.

Pak J Pharm Sci 2022 Jan;35(1(Supplementary)):227-231

Department of Pharmacy, University of Lahore, Gujrat Campus, Pakistan.

Chitosan (CHT) based biodegradable nanovectors were synthesized and modified with poly ethylene glycol 4000 (PEG-4000). CHT having medium molecular weight with 75% to 85% deacetylation was phthaloylated with phthalic anhydride, followed by PEGylation using PEG-4000. After confirmation of successful PEGylation by fourier transforminfra red spectroscopy (FTIR), the modified polymer was further processed to develop the nanocarrier using ionic gelation method by the addition of sodium tripolyphosphate (NaTPP). Read More

View Article and Full-Text PDF
January 2022

Mechanisms Affecting Physical Aging and Swelling by Blending an Amphiphilic Component.

Int J Mol Sci 2022 Feb 16;23(4). Epub 2022 Feb 16.

Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.

Polymer blending is a promising method to overcome stability obstacles induced by physical aging and swelling of implant scaffolds prepared from amorphous polymers in biomedical application, since it will not bring potential toxicity compared with chemical modification. However, the mechanism of polymer blending still remains unclearly explained in existing studies that fail to provide theoretical references in material R&D processes for stability improvement of the scaffold during ethylene oxide (EtO) sterilization, long-term storage, and clinical application. In this study, amphiphilic poly(ethylene glycol)-co-poly(lactic acid) (PELA) was blended with amorphous poly(lactic-co-glycolic acid) (PLGA) because of its good miscibility so as to adjust the glass transition temperature (Tg) and hydrophilicity of electrospun PLGA membranes. Read More

View Article and Full-Text PDF
February 2022

Shell-Sheddable Micelles Based on Poly(ethylene glycol)-hydrazone-poly[R,S]-3-hydroxybutyrate Copolymer Loaded with 8-Hydroxyquinoline Glycoconjugates as a Dual Tumor-Targeting Drug Delivery System.

Pharmaceutics 2022 Jan 26;14(2). Epub 2022 Jan 26.

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34, M. Curie-Skłodowskiej St., 41-819 Zabrze, Poland.

The development of selective delivery of anticancer drugs into tumor tissues to avoid systemic toxicity is a crucial challenge in cancer therapy. In this context, we evaluated the efficacy of a combination of nanocarrier pH-sensitivity and glycoconjugation of encapsulated drugs, since both vectors take advantage of the tumor-specific Warburg effect. Herein, we synthesized biodegradable diblock copolymer, a poly(ethylene glycol)-hydrazone linkage-poly[R,S]-3-hydroxybutyrate, which could further self-assemble into micelles with a diameter of ~55 nm. Read More

View Article and Full-Text PDF
January 2022

Endothelial cell-targeting, ROS-ultrasensitive drug/siRNA co-delivery nanocomplexes mitigate early-stage neutrophil recruitment for the anti-inflammatory treatment of myocardial ischemia reperfusion injury.

Acta Biomater 2022 04 19;143:344-355. Epub 2022 Feb 19.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China. Electronic address:

Neutrophils serve as a key contributor to the pathophysiology of myocardial ischemia reperfusion injury (MIRI), because the unregulated activation and infiltration of neutrophils lead to overwhelming inflammation in the myocardium to cause tissue damage. Herein, endothelial cell-targeting and  reactive oxygen species (ROS)-ultrasensitive nanocomplexes (NCs) were developed to mediate efficient co-delivery of VCAM-1 siRNA (siVCAM-1) and dexamethasone (DXM), which cooperatively inhibited neutrophil recruitment by impeding neutrophil migration and adhesion. RPPT was first synthesized via crosslinking of PEI 600 with ditellurium followed by modification with PEG and the endothelial cell-targeting peptide cRGD. Read More

View Article and Full-Text PDF

Construction of multifunctional micro-patterned PALNMA/PDADMAC/PEGDA hydrogel and intelligently responsive antibacterial coating HA/BBR on Mg alloy surface for orthopedic application.

Mater Sci Eng C Mater Biol Appl 2022 Jan 29;132:112636. Epub 2021 Dec 29.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China. Electronic address:

In recent years, magnesium alloys (MgA) have been reckoned as the most promising material of biomedical importance on account of its excellent degradable properties and mechanical properties mimicking natural bone tissues. However, MgA are prone to rapid corrosion under physiological conditions, causing toxicity around the neighboring tissues. In addition, they are susceptible to bacterial colonization, a detrimental factor for medical causes. Read More

View Article and Full-Text PDF
January 2022