2,940 results match your criteria Toxicity Cyanide


Investigating the cause of -associated liver disease (BALD) in cattle: Progoitrin-derived nitrile toxicosis in rats.

Toxicon X 2020 Mar 30;5:100021. Epub 2019 Dec 30.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

A large outbreak of liver toxicity in dairy cows that were consuming swede (rutabaga, ssp. ) crops in Southland and Otago, New Zealand in 2014 prompted the search for the toxin(s) responsible for brassica-associated liver disease (BALD). Analysis of swede plant material showed that the ultra-dominant glucosinolate was progoitrin. Read More

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http://dx.doi.org/10.1016/j.toxcx.2019.100021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285968PMC

Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice.

PeerJ 2020 21;8:e9232. Epub 2020 May 21.

Department of Biotechnology, Faculty of Science, Taif University, Taif, Makkah, Kingdom of Saudi Arabia.

Background: Little is known regarding the toxic and therapeutic doses of amygdalin. Treatment regimens and schedules can vary between humans and animal models, and there have been reports of cyanide toxicity due to amygdalin use.

Objective: The aim of this study was to evaluate the effect of different doses of amygdalin on antioxidant gene expression and suppression of oxidative damage in mice. Read More

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http://dx.doi.org/10.7717/peerj.9232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246030PMC

Gadolinium-doped Au@prussian blue nanoparticles as MR/SERS bimodal agents for dendritic cell activating and tracking.

Theranostics 2020 15;10(13):6061-6071. Epub 2020 May 15.

College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, 94 Weijin Road, Tianjin 300071, China.

tracking of dendritic cell (DC) migration to the lymphatic system is essential for evaluating the outcome of DC-based immunotherapies. Novel multimodal imaging strategies with high analytical performance are urgently needed to supply complementary information about the migration and colonization of DCs. In this study, we designed a bimodal imaging agent, namely Au@Prussian blue-Gd@ovalbumin nanoparticles (APG@OVA NPs), for activating DCs and real-time tracking of DC migration process by magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.7150/thno.42114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255006PMC

Assessment of zebrafish embryo photomotor response sensitivity and phase-specific patterns following acute- and long-duration exposure to neurotoxic chemicals and chemical weapon precursors.

J Appl Toxicol 2020 May 6. Epub 2020 May 6.

U.S. Army Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, Maryland.

Zebrafish are an attractive model for chemical screening due to their adaptability to high-throughput platforms and ability to display complex phenotypes in response to chemical exposure. The photomotor response (PMR) is an established and reproducible phenotype of the zebrafish embryo, observed 24 h post-fertilization in response to a predefined sequence of light stimuli. In an effort to evaluate the sensitivity and effectiveness of the zebrafish embryo PMR assay for toxicity screening, we analyzed chemicals known to cause both neurological effects and developmental abnormalities, following both short (1 h) and long (16 h+) duration exposures. Read More

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http://dx.doi.org/10.1002/jat.3984DOI Listing

Antidotal effects of methylene blue against cyanide neurological toxicity: in vivo and in vitro studies.

Ann N Y Acad Sci 2020 May 6. Epub 2020 May 6.

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.

The aim of the present study was to determine whether methylene blue (MB) could directly oppose the neurological toxicity of a lethal cyanide (CN) intoxication. KCN, infused at the rate of 0.375 mg/kg/min intravenously, produced 100% lethality within 15 min in unanaesthetized rats (n = 12). Read More

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http://dx.doi.org/10.1111/nyas.14353DOI Listing

Evaluating the toxicity of polyurethane during marine clay stabilisation.

Environ Sci Pollut Res Int 2020 Jun 8;27(17):21252-21259. Epub 2020 Apr 8.

School of Civil Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.

In civil engineering, many geotechnical and forensic projects employ polyurethane (PU) for ground improvement, and the results have shown to be effective in terms of time and cost savings. However, similar to many other chemical stabilisers, the use of PU for soil stabilisation may have environmental repercussions. Therefore, this paper utilised a toxicity characteristic leaching procedure (TCLP) to investigate the potential for ground contamination resulting from the application of PU for the stabilisation of marine clay. Read More

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http://dx.doi.org/10.1007/s11356-020-08549-yDOI Listing

Persulfate enhanced electrochemical oxidation of highly toxic cyanide-containing organic wastewater using boron-doped diamond anode.

Chemosphere 2020 Aug 16;252:126499. Epub 2020 Mar 16.

State Key Laboratory of Powder Metallurgy, School of Materials Science and Engineering, Central South University, Changsha, 410083, People's Republic of China.

Cyanide-containing organic wastewater is discharged in large quantities by coking, electroplating and pharmaceutical industries, which seriously endangers environmental safety and human health. In this paper, Electrochemical Oxidation-Persulfate (EO-PS) Advanced Oxidation Process (AOP) was firstly used to treat high concentration cyanide-containing organic wastewater obtained from a chemical enterprise. The potential application of this process in the treatment of high concentration cyanide-containing organic wastewater was explored for the first time, and the effects of current density, initial pH, temperature and initial concentration on chemical oxygen demand (COD), total organic carbon (TOC) and total cyanide (CN) removal in wastewater were systematically investigated. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126499DOI Listing

Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation.

Biomol Concepts 2020 Mar 17;11(1):32-56. Epub 2020 Mar 17.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India-781039.

The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition constants. The acute onset of toxicity and CN's mg/Kg LD50 (μM lethal concentration) suggests that the classical hemeFe binding-based inhibition rationale is untenable to account for the toxicity of CN. In vitro mechanistic probing of CN-mediated inhibition of hemeFe reductionist systems was explored as a murburn model for mitochondrial oxidative phosphorylation (mOxPhos). Read More

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http://dx.doi.org/10.1515/bmc-2020-0004DOI Listing

Mitophagy is involved in chromium (VI)-induced mitochondria damage in DF-1 cells.

Ecotoxicol Environ Saf 2020 May 6;194:110414. Epub 2020 Mar 6.

College of Veterinary Medicine, Shandong Agricultural University, Taìan, Shandong, 271018, China. Electronic address:

Cr (VI), which is a common heavy metal pollutant with strong oxidizing property, exists widely in nature. Organisms can be exposed to Cr (VI) through various means. Cr (VI) causes mitochondrial dysfunction after being absorbed by cells. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110414DOI Listing

Types and clinical outcomes of chemical ingestion in emergency departments in South Korea (2011-2016).

PLoS One 2020 4;15(3):e0229939. Epub 2020 Mar 4.

Department of Emergency Medicine, Ewha Womans University, Seoul, South Korea.

Objective: This study aims to provide basic data on the types and frequency of chemical ingestions and the clinical outcomes of chemical ingestion injury.

Methods: This study retrospectively analyzed the data obtained from the Emergency Department-Based Injury In-depth Surveillance of the Korea Centers for Disease Control and Prevention (South Korea) from 2011 to 2016. Patients ingesting chemicals aged ≥ 18 years were included, but those ingesting unknown chemical substances or with unknown clinical outcomes were excluded. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055891PMC

Amygdalin - A pharmacological and toxicological review.

J Ethnopharmacol 2020 May 27;254:112717. Epub 2020 Feb 27.

College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610036, PR China. Electronic address:

Ethnopharmacological Relevance: Amygdalin is commonly distributed in plants of the Rosaceae, such as peach, plum, loquat, apple and bayberry, but most notably in the seeds (kernels) of apricot almonds. As a naturally aromatic cyanogenic compound, it has long been used in Asia, Europe and other regions for the treatment of various diseases including cough, asthma, nausea, leprosy and leukoderma. Importantly, in recent years, an increasing attention has been paid to its antitumor effect. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112717DOI Listing

In vitro metabolites characterization of ponatinib in human liver microsomes using ultra-high performance liquid chromatography combined with Q-Exactive-Orbitrap tandem mass spectrometry.

Biomed Chromatogr 2020 Jun 12;34(6):e4819. Epub 2020 Mar 12.

Department of Pharmacy, Weifang People's Hospital, Weifang, Shandong Province, China.

Ponatinib is an oral drug for the treatment of chronic myeloid leukemia and acute lymphoblastic leukemia, which has been reported to increase the risk of hepatotoxicity. The aim of this study was to characterize the metabolites of ponatinib in human liver microsomes as well as its reactive metabolites. Ponatinib was incubated with human liver microsomes in the presence of NADPH and trapping agents (glutathione or potassium cyanide). Read More

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http://dx.doi.org/10.1002/bmc.4819DOI Listing

Assembling PVP-Au NPs as portable chip for sensitive detection of cyanide with surface-enhanced Raman spectroscopy.

Anal Bioanal Chem 2020 May 29;412(12):2863-2871. Epub 2020 Feb 29.

Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui, China.

Cyanide (C≡N) can lead to blood, cardiovascular system, and nervous system disorders owing to the acute and chronic toxicity; thus, aiming at the group or individual poisoning incidents, it is necessary to develop the sensitive and credible method for rapid on-site detection of poisons cyanide. Surface-enhanced Raman spectroscopy (SERS) with the advantages of providing fingerprint information of target molecules and single-molecules sensitivity has been widely used in on-site analysis; however, the SERS measurements always suffer from the problem of the stability of substrates. Here, the polyvinylpyrrolidone (PVP)-stabilized Au NPs (PVP-Au NPs) have been assembled through the simple, convenient evaporation-induced strategy with the large-scale hotspots substrates. Read More

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http://dx.doi.org/10.1007/s00216-020-02517-8DOI Listing

The role of cyanide-resistant respiration in Solanum tuberosum L. against high light stress.

Plant Biol (Stuttg) 2020 May 6;22(3):425-432. Epub 2020 Mar 6.

School of Life Sciences, Lanzhou University, Lanzhou, China.

Cyanide-resistant respiration in potato mitochondria is an important pathway for energy dissipation. It can be activated by high light; however, it is unclear what roles cyanide-resistant respiration plays in the response to high light stress in potato. We designed a CRISPR vector for the functional gene StAOX of the potato cyanide-resistant respiratory pathway. Read More

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http://dx.doi.org/10.1111/plb.13098DOI Listing

Role of the Dihydrodipicolinate Synthase DapA1 on Iron Homeostasis During Cyanide Assimilation by the Alkaliphilic Bacterium CECT5344.

Front Microbiol 2020 23;11:28. Epub 2020 Jan 23.

Departamento de Bioquímica y Biología Molecular, Universidad de Córdoba, Córdoba, Spain.

Cyanide is a toxic compound widely used in mining and jewelry industries, as well as in the synthesis of many different chemicals. Cyanide toxicity derives from its high affinity for metals, which causes inhibition of relevant metalloenzymes. However, some cyanide-degrading microorganisms like the alkaliphilic bacterium CECT5344 may detoxify hazardous industrial wastewaters that contain elevated cyanide and metal concentrations. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989483PMC
January 2020

Antidotes in Poisoning.

Indian J Crit Care Med 2019 Dec;23(Suppl 4):S241-S249

Medical Intensive Care Unit, Division of Critical Care, Christian Medical College, Vellore, Tamil Nadu, India.

Introduction: Antidotes are agents that negate the effect of a poison or toxin. Antidotes mediate its effect either by preventing the absorption of the toxin, by binding and neutralizing the poison, antagonizing its end-organ effect, or by inhibition of conversion of the toxin to more toxic metabolites. Antidote administration may not only result in the reduction of free or active toxin level, but also in the mitigation of end-organ effects of the toxin by mechanisms that include competitive inhibition, receptor blockade or direct antagonism of the toxin. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996653PMC
December 2019

Classical and murburn explanations for acute toxicity of cyanide in aerobic respiration: A personal perspective.

Toxicology 2020 Feb 30;432:152369. Epub 2020 Jan 30.

Satyamjayatu: The Science & Ethics Foundation, Snehatheeram, Kulappully, Shoranur-2 (PO), Kerala, 679122, India.

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http://dx.doi.org/10.1016/j.tox.2020.152369DOI Listing
February 2020

Acute and subchronic oral toxicity assessments of (Combretaceae) in Wistar rats.

Toxicol Rep 2020 18;7:162-168. Epub 2020 Jan 18.

Faculty of Sciences, University of Lomé, Togo.

Background: (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inflammation, malaria and liver ailments. In our recent research we demonstrated that CM has nephroprotective potentials in diabetes mellitus, hypertension and renal disorders. However, to the best of our knowledge, no systematic study concerning its toxicity profile has been reported. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976914PMC
January 2020

Challenging the current paradigm of the chemiosmotic theory for cyanide toxicity.

Authors:
Kendall Wallace

Toxicology 2020 Feb 21;432:152377. Epub 2020 Jan 21.

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http://dx.doi.org/10.1016/j.tox.2020.152377DOI Listing
February 2020

A Near-Infrared Fluorescence Chemosensor Based on Isothiocyanate-Aza-BODIPY for Cyanide Detection at the Parts per Billion Level: Applications in Buffer Media and Living Cell Imaging.

Chempluschem 2019 03 5;84(3):252-259. Epub 2019 Feb 5.

Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000, Thailand.

A near-infrared chemodosimeter based on an aza-BODIPY dye was designed and synthesized. The sensor contains isothiocyanate groups for cyanide ion sensing. The sensing function was illustrated via the fluorescence changes in near-infrared frequencies as well as chromogenic changes which could be easily visualized with a detection limit of 19 ppb. Read More

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http://dx.doi.org/10.1002/cplu.201800574DOI Listing

Is there enough evidence to classify cycloalkyl amine substituents as structural alerts?

Biochem Pharmacol 2020 Apr 10;174:113796. Epub 2020 Jan 10.

Drug Metabolism and Pharmacokinetics, Myokardia, Inc., South San Francisco CA 94080, United States.

Basic amine substituents provide several pharmacokinetic benefits relative to acidic and neutral functional groups, and have been extensively utilized as substituents of choice in drug design. On occasions, basic amines have been associated with off-target pharmacology via interactions with aminergic G-protein coupled receptors, ion-channels, kinases, etc. Structural features associated with the promiscuous nature of basic amines have been well-studied, and can be mitigated in a preclinical drug discovery environment. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.113796DOI Listing

A Comparison of Potential Azide Antidotes in a Mouse Model.

Chem Res Toxicol 2020 Feb 23;33(2):594-603. Epub 2020 Jan 23.

Department of Environmental and Occupational Health, Graduate School of Public Health , The University of Pittsburgh , 130 DeSoto Street , Pittsburgh , Pennsylvania 15219 , United States.

Three cobalt-containing macrocyclic compounds previously shown to antagonize cyanide toxicity have been comparatively evaluated for the amelioration of sublethal azide toxicity in juvenile (7-8 weeks) Swiss-Webster mice. The lowest effective doses were determined for hydroxocobalamin, a cobalt porphyrin, and a cobalt-Schiff base macrocycle by giving the antidotes 5 min prior to the toxicant, 27 mg (415 μmol) /kg sodium azide. Both male and female mice were evaluated for their response to the toxicant as well as the antidotes, and no significant differences were noted once weight differences were taken into account. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.9b00422DOI Listing
February 2020

Types of pesticides involved in domestic and wild animal poisoning in Italy.

Sci Total Environ 2020 Mar 15;707:136129. Epub 2019 Dec 15.

Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy.

Data obtained from samples of poisoned domestic and wild animals sent for toxicological evaluation during the period between 2005 and 2014 have been analyzed. Among the 4606 tested samples, the majority of which were collected in the northern regions of Italy, 2006 (43.55%) were found positive for pesticides. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.136129DOI Listing

Understanding the delayed expression of Al resistance in signal grass (Urochloa decumbens).

Ann Bot 2020 Apr;125(5):841-850

The University of Queensland, School of Agriculture and Food Sciences, St. Lucia, Queensland, Australia.

Background And Aims: Signal grass (Urochloa decumbens) is a widely used pasture grass in tropical and sub-tropical areas due to its high aluminiun (Al) resistance. However, the underlying mechanisms conferring this resistance are not clearly understood.

Methods: The Al concentrations of bulk root tissues and the intracellular compartment were examined, including the impact of a metabolic inhibitor, carbonyl cyanide m-chlorophenyl hydrazone (CCCP). Read More

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http://dx.doi.org/10.1093/aob/mcz206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182589PMC

Water-soluble fluorescent probe for simultaneous detection of cyanide, hypochlorite and bisulfite at different emission wavelengths.

Anal Biochem 2020 02 16;591:113539. Epub 2019 Dec 16.

Institute of Theoretical Chemistry, Laboratory of Theoretical and Computational Chemistry, Jilin University, Changchun, 130023, PR China. Electronic address:

A fluorescent probe that responds at distinct wavelengths upon exposure to cyanide, hypochlorite, and bisulfite was synthesized. As a result, an easy to apply analytical methodology was developed for the detection of these ions. The feasibility of this method was evaluated by theoretical calculations. Read More

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http://dx.doi.org/10.1016/j.ab.2019.113539DOI Listing
February 2020
2.219 Impact Factor

Sodium nitroprusside (SNP) improves tolerance to arsenic (As) toxicity in Vicia faba through the modifications of biochemical attributes, antioxidants, ascorbate-glutathione cycle and glyoxalase cycle.

Chemosphere 2020 Apr 26;244:125480. Epub 2019 Nov 26.

University of Agriculture Faisalabad, Pakistan.

The present study was conducted to evaluate the effect of arsenic (As) toxicity and the mitigating role of nitric oxide (NO) donor sodium nitroprusside (SNP) on Vicia faba. Arsenics stress decreased the growth and biomass yield, and photosynthetic pigments, but it enhanced As accumulation. Supplementation of NO enhanced the afore-mentioned parameters except As accumulation which decreased in both shoot and root. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125480DOI Listing
April 2020
3.340 Impact Factor

A respiration substrate-less isolation method for acute toxicity assessment.

Chemosphere 2020 Apr 29;244:125511. Epub 2019 Nov 29.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China. Electronic address:

Respiration substrate (RS)-less isolation method was developed for enhancing the sensitivity of acute toxicity assessment of heavy metal ions. RS was removed from the first step of previous isolation method, which was an effective strategy for improving acute toxicity assessment. 50% inhibiting concentration (IC) values of Cu, Cd, Zn, Hg and Ni were 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125511DOI Listing

Interactive Effects of Salicylic Acid and Nitric Oxide in Enhancing Rice Tolerance to Cadmium Stress.

Int J Mol Sci 2019 Nov 18;20(22). Epub 2019 Nov 18.

Plant Stress Research Group, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.

Cadmium (Cd) is one of the prominent environmental hazards, affecting plant productivity and posing human health risks worldwide. Although salicylic acid (SA) and nitric oxide (NO) are known to have stress mitigating roles, little was explored on how they work together against Cd-toxicity in rice. This study evaluated the individual and combined effects of SA and sodium nitroprusside (SNP), a precursor of NO, on Cd-stress tolerance in rice. Read More

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http://dx.doi.org/10.3390/ijms20225798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888396PMC
November 2019
2.862 Impact Factor

Identifying degradation products responsible for increased toxicity of UV-Degraded insensitive munitions.

Chemosphere 2020 Feb 24;240:124958. Epub 2019 Sep 24.

U.S. Army Engineer Research and Development Center, Environmental Laboratory, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.

Degradation of insensitive munitions (IMs) by ultraviolet (UV) light has become a topic of concern following observations that some UV-degradation products have increased toxicity relative to parent compounds in aquatic organisms. The present investigation focused on the Army's IM formulation, IMX-101, which is composed of three IM constituents: 2,4-dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and nitroguanidine (NQ). The IM constituents and IMX-101 were irradiated in a UV photo-reactor and then administered to Daphnia pulex in acute (48 h) exposures comparing toxicities relative to the parent materials. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.124958DOI Listing
February 2020

Long-term peroral administration of bitter apricot seeds influences cortical bone microstructure of rabbits.

J Anim Physiol Anim Nutr (Berl) 2020 Jan 14;104(1):362-370. Epub 2019 Nov 14.

Department of Zoology and Anthropology, Constantine the Philosopher University, Nitra, Slovak Republic.

Apricot seeds due to the presence of cyanogenic glycoside amygdalin belong to the popular "alternative cancer cures", although anticancer effect of amygdalin remains controversial. This in vivo study points to the effect of long-term peroral administration of bitter apricot seeds on bone microstructure of rabbits since chronic amygdalin toxicity in relation to bone parameters has not been investigated yet. Rabbits (n = 16) were randomly divided into four experimental groups of 4 animals each. Read More

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http://dx.doi.org/10.1111/jpn.13229DOI Listing
January 2020

Cyanide concentrations in blood and tissues of fire victims.

Leg Med (Tokyo) 2019 Nov 25;41:101628. Epub 2019 Oct 25.

Department of Legal Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata-cho 2-5-1, Kita-ku, Okayama 700-8558, Japan. Electronic address:

Cyanide poisoning has been regarded to contribute the fatal outcome in fire victims. The toxicity of inhaled hydrogen cyanide (HCN) at the cellular level was evaluated considering the impact of methemoglobin (MetHb) produced by fire gases. Cyanide (CN) concentrations and total hemoglobin contents were measured in right heart blood (RHB) and seven organs/tissues (basal ganglia, brain stem, heart, lung, liver, kidney and psoas muscle) collected from 20 fire fatalities. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.101628DOI Listing
November 2019

Nitric oxide alleviates selenium toxicity in rice by regulating antioxidation, selenium uptake, speciation and gene expression.

Environ Pollut 2020 Feb 1;257:113540. Epub 2019 Nov 1.

College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China; Microelement Research Center, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

In plants, excess selenium (Se) causes toxicity, while the beneficial effects of nitric oxide (NO) have verified in plants under various abiotic conditions. In order to ensure safely Se-enriched rice production, the objective of the research was to clarify how exogenous NO alleviated high Se toxicity in rice. Under high Se (25 μM) stress, the effects of exogenous NO (by applying sodium nitroprusside, an exogenous NO donor) on growth parameters, Se content, Se speciation, photosynthesis, antioxidant system, expressions of Se transport and metabolism-related genes (phosphate transporter, OsPT2; S-adenosylmethionine synthase 1, OsSAMS1; cysteine synthase, OsCS; Se-binding protein gene, OsSBP1) in rice seedlings were investigated by a hydroponic experiment. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113540DOI Listing
February 2020
4.143 Impact Factor

The dynamics of cyanide defences in the life cycle of an aposematic butterfly: Biosynthesis versus sequestration.

Insect Biochem Mol Biol 2020 01 4;116:103259. Epub 2019 Nov 4.

Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871, Frederiksberg, Denmark. Electronic address:

Heliconius butterflies are highly specialized in Passiflora plants, laying eggs and feeding as larvae only on them. Interestingly, both Heliconius butterflies and Passiflora plants contain cyanogenic glucosides (CNglcs). While feeding on specific Passiflora species, Heliconius melpomene larvae are able to sequester simple cyclopentenyl CNglcs, the most common CNglcs in this plant genus. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.103259DOI Listing
January 2020

Conditional quorum-sensing induction of a cyanide-insensitive terminal oxidase stabilizes cooperating populations of Pseudomonas aeruginosa.

Nat Commun 2019 11 1;10(1):4999. Epub 2019 Nov 1.

School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, China.

Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by which cooperators selectively protect themselves from the toxicity of cyanide remained unresolved. Read More

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http://dx.doi.org/10.1038/s41467-019-13013-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825135PMC
November 2019

Can Amygdalin Provide any Benefit in Integrative Anticancer Treatment?

Klin Onkol 2019 ;32(5):360-366

Background: Amygdalin is a natural compound primarily found in seeds of fruit trees. In the human body, it is hydrolyzed to benzaldehyde, glucose, and cyanide, which is considered the active component of amygdalin. The semi-synthetic form of amygdalin is known under the commercial name Laetrile® or as vitamin B17. Read More

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http://dx.doi.org/10.14735/amko2019360DOI Listing
March 2020
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Liquid chromatography-tandem mass spectrometry metabolic profiling of nazartinib reveals the formation of unexpected reactive metabolites.

R Soc Open Sci 2019 Aug 14;6(8):190852. Epub 2019 Aug 14.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Kingdom of Saudi Arabia.

Nazartinib (EGF816, NZB) is a promising third-generation human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This novel irreversible mutant-selective EGFR inhibitor targets EGFR containing both the resistance mutation (T790M) and the activating mutations (L858R and Del19), while it does not affect wild-type EGFR. However, the metabolic pathway and bioactivation mechanisms of NZB are still unexplored. Read More

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http://dx.doi.org/10.1098/rsos.190852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731747PMC
August 2019
1 Read

Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds.

Nat Commun 2019 10 3;10(1):4490. Epub 2019 Oct 3.

School of Materials Science and Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, 300072, Tianjin, China.

The application of photothermal therapy to treat bacterial infections remains a challenge, as the high temperatures required for bacterial elimination can damage healthy tissues. Here, we develop an exogenous antibacterial agent consisting of zinc-doped Prussian blue (ZnPB) that kills methicillin-resistant Staphylococcus aureus in vitro and in a rat model of cutaneous wound infection. Local heat triggered by the photothermal effect accelerates the release and penetration of ions into the bacteria, resulting in alteration of intracellular metabolic pathways and bacterial killing without systemic toxicity. Read More

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http://dx.doi.org/10.1038/s41467-019-12429-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776522PMC
October 2019
1 Read
10.742 Impact Factor

Littered cigarette butt as a well-known hazardous waste: A comprehensive systematic review.

J Hazard Mater 2020 02 19;383:121242. Epub 2019 Sep 19.

Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Most of cigarettes used in the world have filters. Following smoking, the cigarette butts (CBs) are often littered as wastes in the environment. CBs generally contain several toxic substances that are trapped in the cigarette filter. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.121242DOI Listing
February 2020
3 Reads

Antigenotoxic and antioxidant potential of medicinal mushrooms (Immune Assist) against DNA damage induced by free radicals-an in vitro study.

Mutat Res 2019 09 1;845:403078. Epub 2019 Aug 1.

Center for Biological Research, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia.

Immune Assist (IA) is produced from extract of six species of medical mushrooms: Agaricus blazei - Cordyceps sinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The genoprotective potential of IA was evaluated for the first time. Significant antigenotoxic effects were detected in human peripheral blood cells against HO induced DNA damage, in the pretreatment and in the posttreatment. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2019.06.008DOI Listing
September 2019

Prussian blue analogue nanoenzymes mitigate oxidative stress and boost bio-fermentation.

Nanoscale 2019 Nov 25;11(41):19497-19505. Epub 2019 Sep 25.

Institute of Health and Biomedical Innovation, School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane QLD 4000, Australia. and Translational Research Institute, Brisbane, QLD 4102, Australia.

Oxidative stress in cells caused by the accumulation of reactive oxygen species (ROS) is a common cause of cell function degeneration, cell death and various diseases. Efficient, robust and inexpensive nanoparticles (nanoenzymes) capable of scavenging/detoxifying ROS even in harsh environments are attracting strong interest. Prussian blue analogues (PBAs), a prominent group of metalorganic nanoparticles (NPs) with the same cyanometalate structure as the traditional and commonly used Prussian blue (PB), have long been envisaged to mimic enzyme activities for ROS scavenging. Read More

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http://dx.doi.org/10.1039/c9nr04951gDOI Listing
November 2019
1 Read

Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells.

Int J Biol Macromol 2019 Dec 12;141:1220-1227. Epub 2019 Sep 12.

Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong 271018, China. Electronic address:

This study aimed to investigate the potential protective effects of Platycodon grandiflorus polysaccharide (PGPS) on carbonyl cyanide 3-chlorophenylhydrazone (CCCP)-induced mitochondrial apoptosis in 3D4/21 cells. Apoptosis-related indicators such as cell viability, apoptosis rate, mitochondrial membrane potential (MMP), and apoptosis-related protein were examined. Results indicated that PGPS can inhibit CCCP-induced cell damage, with cell-survival rate reaching 81% and apoptotic rate decreasing to 23%. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.09.086DOI Listing
December 2019
1 Read

Fast fabrication of reusable polyethersulfone microbial biosensors through biocompatible phase separation.

Talanta 2020 Jan 29;206:120192. Epub 2019 Jul 29.

Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain.

In biosensors fabrication, entrapment in polymeric matrices allows efficient immobilization of the biorecognition elements without compromising their structure and activity. When considering living cells, the biocompatibility of both the matrix and the polymerization procedure are additional critical factors. Bio-polymeric gels (e. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.120192DOI Listing
January 2020

Nitric oxide improves tolerance to arsenic stress in Isatis cappadocica desv. Shoots by enhancing antioxidant defenses.

Chemosphere 2020 Jan 12;239:124523. Epub 2019 Aug 12.

Laboratory for Reactive Oxygen and Nitrogen Species Signaling Under Plant Stress Conditions, Department of Biochemistry and Cellular and Molecular Biology of Plants, Estación Experimental del Zaidín (CSIC), Profesor Albareda 1, 18008, Granada, Spain. Electronic address:

Arsenic (As) is a toxic metalloid that severely hampers plant growth and also poses health risks for humans through the food chain. Although nitric oxide (NO) is known to improve plant resistance to multiple stresses including metal toxicity, little is known about its role in the As tolerance of hyperaccumulator plants. This study investigates the role of the exogenously applied NO donor, sodium nitroprusside (SNP), in improving the As tolerance of Isatis cappadocica, which has been reported to hyperaccumulate As. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.124523DOI Listing
January 2020
3 Reads
3.340 Impact Factor

[2]Pseudorotaxane-Based Supramolecular Optical Indicator for the Visual Detection of Cellular Cyanide Excretion.

Chemistry 2019 Nov 16;25(63):14447-14453. Epub 2019 Oct 16.

State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China.

Cyanide is extremely hazardous to living organisms and the environment. Owing to its wide range of applications and high toxicity, the development of functional materials for cyanide detection and sensing is highly desirable. Host-guest complexation between bis(p-phenylene)-34-crown-10 H and N-methylacridinium salt G remarkably decreases the detection limit for cyanide anions compared with that of the guest itself. Read More

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http://dx.doi.org/10.1002/chem.201903577DOI Listing
November 2019
4 Reads
5.731 Impact Factor

Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish.

Dis Model Mech 2019 09 25;12(9). Epub 2019 Sep 25.

Neuroimaging in Cardiovascular Disease (NICAD) Network, University of Sheffield, Sheffield, S10 2TN, UK

Diabetes is associated with dysfunction of the neurovascular unit, although the mechanisms of this are incompletely understood and currently no treatment exists to prevent these negative effects. We previously found that the nitric oxide (NO) donor sodium nitroprusside (SNP) prevents the detrimental effect of glucose on neurovascular coupling in zebrafish. We therefore sought to establish the wider effects of glucose exposure on both the neurovascular unit and on behaviour in zebrafish, and the ability of SNP to prevent these. Read More

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http://dx.doi.org/10.1242/dmm.039867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765192PMC
September 2019

Synthesis and Application of Ruthenium(II) Alkenyl Complexes with Perylene Fluorophores for the Detection of Toxic Vapours and Gases.

Chemistry 2019 Nov 8;25(62):14214-14222. Epub 2019 Oct 8.

Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London, W12 0BZ, UK.

A series of new ruthenium(II) vinyl complexes has been prepared incorporating perylenemonoimide (PMI) units. This fluorogenic moiety was functionalised with terminal alkyne or pyridyl groups, allowing attachment to the metal either as a vinyl ligand or through the pyridyl nitrogen. The inherent low solubility of the perylene compounds was improved through the design of poly-PEGylated (PEG=polyethylene glycol) units bearing a terminal alkyne or a pyridyl group. Read More

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http://dx.doi.org/10.1002/chem.201903303DOI Listing
November 2019

Kinetic data of extraction of cyanide during the soaking process of cassava leaves.

Data Brief 2019 Aug 17;25:104279. Epub 2019 Jul 17.

Department of Chemical Engineering, Institut Teknologi Sepuluh Nopember (ITS), Surabaya 60111, Indonesia.

With the toxicity problems arising from the consumption of hydrogen cyanide (HCN), an acceptable method of processing edible leaves with low HCN level while maintaining maximum nutritional content remain a challenge. This data focuses on the extraction kinetics of cyanide in cassava leaves during the soaking process. Various process parameters conducted at 26 ± 2 °C were evaluated, such as contact times (1-20 h) between the leaves and solvent, as well as the water-to-leaves ratios (spanning a range of 10-50 mL/g). Read More

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http://dx.doi.org/10.1016/j.dib.2019.104279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685679PMC
August 2019
3 Reads

A Novel Mechanism To Prevent HS Toxicity in .

Genetics 2019 10 1;213(2):481-490. Epub 2019 Aug 1.

Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195

Hydrogen sulfide (HS) is an endogenously produced signaling molecule that can be cytoprotective, especially in conditions of ischemia/reperfusion injury. However, HS is also toxic, and unregulated accumulation or exposure to environmental HS can be lethal. In , the hypoxia inducible factor () coordinates the initial transcriptional response to HS, and is essential to survive exposure to low concentrations of HS. Read More

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http://dx.doi.org/10.1534/genetics.119.302326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781907PMC
October 2019
2 Reads