225 results match your criteria Toxicity Ciguatera


Diversity and Toxicity of the Genus Meunier in Brazil, and Detection of 44-Methyl Gambierone in .

Toxins (Basel) 2020 May 15;12(5). Epub 2020 May 15.

Universidade Federal do Paraná, Centro de Estudos do Mar, Cx, Postal 61, Pontal do Paraná PR 83255-976, Brazil.

is a genus of marine benthic dinoflagellates which is widely distributed in tropical and temperate zones. Toxicity has been reported in selected species, although the identity of causative compounds is still controversial. In this study, we investigated the taxonomical and toxicological aspects of species from Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins12050327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290302PMC
May 2020
2.480 Impact Factor

Assessment of Ciguatera and Other Phycotoxin-Related Risks in Anaho Bay (Nuku Hiva Island, French Polynesia): Molecular, Toxicological, and Chemical Analyses of Passive Samplers.

Toxins (Basel) 2020 May 13;12(5). Epub 2020 May 13.

Institut Louis Malardé, UMR 241 EIO, 98713 Papeete, Tahiti, French Polynesia.

Ciguatera poisoning is a foodborne illness caused by the consumption of seafood contaminated with ciguatoxins (CTXs) produced by dinoflagellates from the genera and . The suitability of Solid Phase Adsorption Toxin Tracking (SPATT) technology for the monitoring of dissolved CTXs in the marine environment has recently been demonstrated. To refine the use of this passive monitoring tool in ciguateric areas, the effects of deployment time and sampler format on the adsorption of CTXs by HP20 resin were assessed in Anaho Bay (Nuku Hiva Island, French Polynesia), a well-known ciguatera hotspot. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins12050321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291316PMC
May 2020
2.480 Impact Factor

High sensitivity of rat cardiomyoblast H9c2(2-1) cells to Gambierdiscus toxic compounds.

Aquat Toxicol 2020 Jun 7;223:105475. Epub 2020 Apr 7.

CFE-Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal. Electronic address:

Ciguatera fish poisoning is a frequently reported non-bacterial food-borne illness related to the consumption of seafood contaminated with ciguatoxins, and possibly maitotoxins. These toxins are synthesized by marine dinoflagellate species of Gambierdiscus and Fukuyoa genera, and their abundance is a matter of great concern due to their adverse effects to aquatic life and human health. The present study aims to assess the sensitivity of rat cardiomyoblast H9c2(2-1) cells to Gambierdiscus toxic compounds using concentration- and time-dependent sulforhodamine B (SRB) colorimetric assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2020.105475DOI Listing

Transcriptomic analysis of polyketide synthases in a highly ciguatoxic dinoflagellate, Gambierdiscus polynesiensis and low toxicity Gambierdiscus pacificus, from French Polynesia.

PLoS One 2020 15;15(4):e0231400. Epub 2020 Apr 15.

Laboratoire des Biotoxines Marines, Institut Louis Malardé-UMR 241 EIO, Papeete, Tahiti, French Polynesia.

Marine dinoflagellates produce a diversity of polyketide toxins that are accumulated in marine food webs and are responsible for a variety of seafood poisonings. Reef-associated dinoflagellates of the genus Gambierdiscus produce toxins responsible for ciguatera poisoning (CP), which causes over 50,000 cases of illness annually worldwide. The biosynthetic machinery for dinoflagellate polyketides remains poorly understood. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231400PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159223PMC

Toxicity Characterisation of Species from the Canary Islands.

Toxins (Basel) 2020 Feb 21;12(2). Epub 2020 Feb 21.

Department of Photobiology and Toxinology of Phytoplankton, Instituto de Investigaciones Marinas, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain.

In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region. Five species, , , , and , have been detected in macrophytes from this area and are known to produce the ciguatoxins (CTXs) that cause CFP. A characterization of the toxicity of these species is the first step in identifying locations in the Canary Islands at risk of CFP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins12020134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076799PMC
February 2020

Distribution and potential toxicity of benthic harmful dinoflagellates in waters of Florida Bay and the Florida Keys.

Mar Environ Res 2020 Mar 23;155:104891. Epub 2020 Jan 23.

University of Maryland Center for Environmental Science, Horn Point Laboratory, P.O. Box 775, Cambridge, MD, 21613, USA.

Few studies have been carried out on benthic dinoflagellates along the Florida Keys, and little is known about their distribution or toxicity in Florida Bay. Here, the distribution and abundance of benthic dinoflagellates was explored in northern and eastern Florida Bay and along the bay and ocean sides of the Florida Keys. Isolates were brought into culture and their toxicity was tested with oyster larvae bioassays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.marenvres.2020.104891DOI Listing

Presence of CTXs in moray eels and dusky groupers in the marine environment of the Canary Islands.

Aquat Toxicol 2020 Apr 31;221:105427. Epub 2020 Jan 31.

Division of Fish Health and Pathology, University Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416 Arucas, Las Palmas, Spain.

Local population frequently consumes moray eels and dusky groupers from the Canary Islands. These species are top predators and the interactions between them include predation but also, in some cases, collaborative hunting. These fish are well known to cause ciguatera (CFP) outbreaks in several marine areas such as Japan, Hawaii, French Polynesia and Caribe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2020.105427DOI Listing

Ciguatera Fish Poisoning: The Risk from an Aotearoa/New Zealand Perspective.

Toxins (Basel) 2020 01 15;12(1). Epub 2020 Jan 15.

AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand.

Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins12010050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020403PMC
January 2020

Global impact of ciguatoxins and ciguatera fish poisoning on fish, fisheries and consumers.

Environ Res 2020 Mar 7;182:109111. Epub 2020 Jan 7.

IPMA - Instituto Português do Mar da Atmosfera, Rua Alfredo Magalhães Ramalho, 6, 1495-006, Lisbon, Portugal; CCMAR - Centre of Marine Sciences, University of Algarve, Campus of Gambelas, 8005-139, Faro, Portugal.

Ciguatera fish poisoning (CFP) is one of the most devastating food-borne illnesses caused by fish consumption. Ciguatoxins (CTXs) are potent neurotoxins synthesized by the benthic microalgae Gambierdiscus spp. and Fukuyoa spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2020.109111DOI Listing

A Curious Case of Ciguatera Fish Poisoning in the Midwest and a Review for Clinicians.

J Emerg Med 2020 Mar 20;58(3):e109-e111. Epub 2019 Dec 20.

Department of Emergency Medicine, Henry Ford Macomb Hospital, Clinton Township, Michigan.

Background: Ciguatera poisoning is one of the most prevalent types of fish poisoning, but it is often underreported, leading many health practitioners to be unfamiliar in correctly identifying and treating this toxicity.

Case Report: We present a case of ciguatera toxicity encountered in an emergency department in a Midwest community hospital setting. A 56-year-old woman presented to the ED with symptoms of perioral numbness, generalized pruritis, and hot/cold temperature reversal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2019.10.017DOI Listing

Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae).

PLoS One 2019 15;14(11):e0224664. Epub 2019 Nov 15.

Climate Change Cluster (C3), University of Technology Sydney, Ultimo, New South Wales, Australia.

Ciguatera fish poisoning (CFP) is an illness contracted through the ingestion of seafood containing ciguatoxins. It is prevalent in tropical regions worldwide, including in Australia. Ciguatoxins are produced by some species of Gambierdiscus. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857910PMC

Development and Validation of PCR-RFLP Assay for Identification of species in the Greater Caribbean region.

J Appl Phycol 2018 Dec 7;30(6):3529-3540. Epub 2018 May 7.

Marine Science Institute - University of Texas at Austin, Port Aransas, USA.

The genus is a recognized group of marine epiphytic-benthic dinoflagellates that produce the toxins that cause ciguatera fish poisoning (CFP). To date, thirteen species and six ribotypes of have been identified, and multiple species commonly co-occur within a single site or epiphyte community. Toxicity can vary by species, thus it is important to be able to differentiate among species for research and monitoring purposes. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759227PMC
December 2018
3 Reads

Morphology, toxicity and molecular characterization of Gambierdiscus spp. towards risk assessment of ciguatera in south central Cuba.

Harmful Algae 2019 06 31;86:119-127. Epub 2019 May 31.

Environment Laboratories, Department of Nuclear Science and Application, International Atomic Energy Agency, 98000, Monaco. Electronic address:

Ciguatera poisoning is caused by the consumption of reef fish or shellfish that have accumulated ciguatoxins, neurotoxins produced by benthic dinoflagellates of the genera Gambierdiscus or Fukuyoa. Although ciguatera constitutes the primary cause of seafood intoxication in Cuba, very little information is available on the occurrence of ciguatoxins in the marine food web and the causative benthic dinoflagellate species. This study conducted on the south-central coast of Cuba reports the occurrence of Gambierdiscus and Fukuyoa genera and the associated benthic genera Ostreopsis and Prorocentrum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2019.05.007DOI Listing
June 2019
5 Reads

An Attempt to Characterize the Ciguatoxin Profile in Causing Ciguatera Fish Poisoning in Macaronesia.

Toxins (Basel) 2019 04 13;11(4). Epub 2019 Apr 13.

University of Vigo, Department of Analytical and Food Chemistry, Campus Universitario de Vigo, 36310 Vigo, Spain.

Ciguatera Fish Poisoning is a worldwide concern caused by the consumption of fish contaminated with ciguatoxins not only in endemic regions in the Pacific Ocean or the Caribbean Sea but also in emerging areas of Macaronesia on the eastern Atlantic. The recent emergence of these toxins in other coastal areas worldwide, prompted the need for the characterization of the risk in these areas. This Ciguatera Fish Poisoning risk has been recently identified as a potential threat in subtropical areas of the Atlantic coast and scientific efforts are being focused in the identification and confirmation of the toxins involved in this potential risk. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/2072-6651/11/4/221
Publisher Site
http://dx.doi.org/10.3390/toxins11040221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521267PMC
April 2019
30 Reads

Predictive score and probability of CTX-like toxicity in fish samples from the official control of ciguatera in the Canary Islands.

Sci Total Environ 2019 Jul 30;673:576-584. Epub 2019 Mar 30.

Division of Fish Health and Pathology, Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, 35416 Arucas, Las Palmas, Spain.

This research identifies factors associated with the contamination by ciguatoxins (CTXs) in a population of fish and proposes a predictive score of the presence of CTX-like toxicity in amberjack samples from the official control program of ciguatera in the Canary Islands of the Directorate-General (DG) Fisheries (Canary Government). Out of the 970 samples of fish studied, 177 (18.2%) samples showed CTX-like toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.03.445DOI Listing
July 2019
32 Reads

Species-specific PCR assays for Gambierdiscus excentricus and Gambierdiscus silvae (Gonyaulacales, Dinophyceae).

J Phycol 2019 06;55(3):730-732

National Oceanic and Atmospheric Administration, National Ocean Service, National Centers for Coastal Ocean Science, Beaufort Laboratory, 101 Pivers Island Rd., Beaufort, North Carolina, 28516, USA.

The two most toxic Gambierdiscus species identified from the Caribbean are G. excentricus and G. silvae. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jpy.12852DOI Listing
June 2019
8 Reads

A radioligand receptor binding assay for ciguatoxin monitoring in environmental samples: Method development and determination of quality control criteria.

J Environ Radioact 2018 Dec 9;192:289-294. Epub 2018 Jul 9.

Environment Laboratories, Department of Nuclear Science and Application, International Atomic Energy Agency, 98000, Monaco. Electronic address:

Ciguatoxins are algal toxins responsible for tens of thousands of human intoxications yearly, both in tropical and subtropical endemic regions as well as worldwide through fish exportation. Previously developed methods for biotoxin surveillance in the environment and seafood include analytical methods and in vivo and in vitro bioassays. The radioligand receptor binding assay (r-RBA) is among the in vitro methodologies currently used for the detection and quantification of marine biotoxins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvrad.2018.06.019DOI Listing
December 2018
15 Reads

Growth and Toxin Production of spp. Can Be Regulated by Quorum-Sensing Bacteria.

Toxins (Basel) 2018 06 22;10(7). Epub 2018 Jun 22.

Shenzhen Public Platform of Screening & Application of Marine Microbial Resources, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

spp. are the major culprit responsible for global ciguatera fish poisoning (CFP). At present, the effects of microbiological factors on algal proliferation and toxin production are poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins10070257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071102PMC
June 2018
13 Reads
2.480 Impact Factor

Investigation of ciguatoxins in invasive lionfish from the greater caribbean region: Implications for fishery development.

PLoS One 2018 20;13(6):e0198358. Epub 2018 Jun 20.

National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America.

Lionfish, native to reef ecosystems of the tropical and sub-tropical Indo-Pacific, were introduced to Florida waters in the 1980s, and have spread rapidly throughout the northwestern Atlantic, Caribbean Sea and the Gulf of Mexico. These invasive, carnivorous fish significantly reduce other fish and benthic invertebrate biomass, fish recruitment, and species richness in reef ecosystems. Fisheries resource managers have proposed the establishment of a commercial fishery to reduce lionfish populations and mitigate adverse effects on reef communities. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198358PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010213PMC
December 2018
83 Reads

Seasonal distribution of Gambierdiscus spp. in Wakasa Bay, the Sea of Japan, and antagonistic relationships with epiphytic pennate diatoms.

Harmful Algae 2018 06 19;76:58-65. Epub 2018 May 19.

Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.

The occurrence of the ciguatera fish poisoning (CFP) causative Gambierdiscus spp. was confirmed in the Sea of Japan for the first time in 2009. This paper reports seasonal distribution of Gambierdiscus spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2018.05.002DOI Listing
June 2018
21 Reads

Experimental evidence of dietary ciguatoxin accumulation in an herbivorous coral reef fish.

Aquat Toxicol 2018 Jul 26;200:257-265. Epub 2018 May 26.

International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco. Electronic address:

Ciguatoxins (CTXs) are potent algal toxins that cause widespread ciguatera poisoning and are found ubiquitously in coral reef food webs. Here we developed an environmentally-relevant, experimental model of CTX trophic transfer involving dietary exposure of herbivorous fish to the CTX-producing microalgae Gambierdiscus polynesiensis. Juvenile Naso brevirostris were fed a gel-food embedded with microalgae for 16 weeks (89 cells g fish daily, 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2018.05.007DOI Listing
July 2018
31 Reads
3.451 Impact Factor

Differential toxin profiles of ciguatoxins in marine organisms: Chemistry, fate and global distribution.

Toxicon 2018 Aug 17;150:124-143. Epub 2018 May 17.

IPMA - Instituto Português do Mar e da Atmosfera, Rua Alfredo Magalhães Ramalho, 6, 1495-006, Lisbon, Portugal; CCMAR - Centre of Marine Sciences, University of Algarve, Campus of Gambelas, 8005-139, Faro, Portugal. Electronic address:

Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affect up to 500,000 people annually due to fish consumption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2018.05.005DOI Listing
August 2018
12 Reads

Highly Sensitive and Practical Fluorescent Sandwich ELISA for Ciguatoxins.

Anal Chem 2018 06 29;90(12):7318-7324. Epub 2018 May 29.

Department of Biological Science, Graduate School of Science , Osaka Prefecture University , Osaka 599-8570 , Japan.

Ciguatera fish poisoning (CFP) caused by the consumption of fish that have accumulated ciguatoxins (CTXs) affects more than 50000 people annually. The spread of CFP causes enormous damage to public health, fishery resources, and the economies of tropical and subtropical endemic regions. The difficulty in avoiding CFP arises from the lack of sensitive and reliable analytical methods for the detection and quantification of CTXs in contaminated fish, along with the normal appearance, smell, and taste of fish contaminated with the causative toxins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.8b00519DOI Listing
June 2018
10 Reads

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons.

Toxins (Basel) 2018 05 10;10(5). Epub 2018 May 10.

Departamento de Farmacología, Farmacia e Tecnoloxía Farmacéutica, Facultade de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, Spain.

Ciguatoxins are polyether marine toxins that act as sodium channel activators. These toxins cause ciguatera, one of the most widespread nonbacterial forms of food poisoning, which presents several symptoms in humans including long-term neurological alterations. Earlier work has shown that both acute and chronic exposure of primary cortical neurons to synthetic ciguatoxin CTX3C have profound impacts on neuronal function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins10050192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983248PMC
May 2018
9 Reads

Tissue Distribution and Elimination of Ciguatoxins in (, Bivalvia) Fed .

Toxins (Basel) 2018 05 10;10(5). Epub 2018 May 10.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, PO Box 30, 98713 Papeete, Tahiti, French Polynesia.

Ciguatera is a foodborne disease caused by the consumption of seafood contaminated with ciguatoxins (CTXs). Ciguatera-like poisoning events involving giant clams () are reported occasionally from Pacific islands communities. The present study aimed at providing insights into CTXs tissue distribution and detoxification rate in giant clams exposed to toxic cells of , in the framework of seafood safety assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins10050189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983245PMC
May 2018
13 Reads
2.480 Impact Factor

Phylogeny, morphology and toxicity of benthic dinoflagellates of the genus Fukuyoa (Goniodomataceae, Dinophyceae) from a subtropical reef ecosystem in the South China Sea.

Harmful Algae 2018 04 17;74:78-97. Epub 2018 Apr 17.

State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China. Electronic address:

Species of Fukuyoa, recently revised from the globular Gambierdiscus, are toxic benthic dinoflagellates associated with ciguatera. In this study, a total of ten strains of Fukuyoa collected from Hong Kong waters were characterized using morphological and phylogenetic analyses. Results from both analyses showed that one of the strains is a putative new species, namely Fukuyoa sp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2018.03.003DOI Listing
April 2018
116 Reads

Toxicological Investigations on the Sea Urchin Tripneustes gratilla (Toxopneustidae, Echinoid) from Anaho Bay (Nuku Hiva, French Polynesia): Evidence for the Presence of Pacific Ciguatoxins.

Mar Drugs 2018 Apr 6;16(4). Epub 2018 Apr 6.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, PO Box 30, 98713 Papeete, Tahiti, French Polynesia.

The sea urchin (, Echinoids) is a source of protein for many islanders in the Indo-West Pacific. It was previously reported to occasionally cause ciguatera-like poisoning; however, the exact nature of the causative agent was not confirmed. In April and July 2015, ciguatera poisonings were reported following the consumption of in Anaho Bay (Nuku Hiva Island, Marquesas archipelago, French Polynesia). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/md16040122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923409PMC
April 2018
12 Reads
2.853 Impact Factor

Immune effects of the neurotoxins ciguatoxins and brevetoxins.

Toxicon 2018 Jul 31;149:6-19. Epub 2018 Jan 31.

Laboratory of Interactions Keratinocytes-Neurons, University of Western Brittany, 22 Avenue Camille Desmoulins, 29200 Brest, France. Electronic address:

Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain, pruritus and cold dysaesthesia), which can persist several weeks and, in some cases, several months or years. NSP is considered a mild form of CFP with similar but less severe symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2018.01.002DOI Listing
July 2018
15 Reads

Pacific Ciguatoxin Induces Excitotoxicity and Neurodegeneration in the Motor Cortex Via Caspase 3 Activation: Implication for Irreversible Motor Deficit.

Mol Neurobiol 2018 Aug 18;55(8):6769-6787. Epub 2018 Jan 18.

Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Hong Kong, Hong Kong.

Consumption of fish containing ciguatera toxins or ciguatoxins (CTXs) causes ciguatera fish poisoning (CFP). In some patients, CFP recurrence occurs even years after exposure related to CTXs accumulation. Pacific CTX-1 (P-CTX-1) is one of the most potent natural substances known that causes predominantly neurological symptoms in patients; however, the underlying pathogenies of CFP remain unknown. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12035-018-0875-5
Publisher Site
http://dx.doi.org/10.1007/s12035-018-0875-5DOI Listing
August 2018
22 Reads

Ciguatoxins activate the Calcineurin signalling pathway in Yeasts: Potential for development of an alternative detection tool?

Environ Res 2018 04 4;162:144-151. Epub 2018 Jan 4.

Laboratoire des Micro-Algues Toxiques, Institut Louis Malardé, UMR 241-EIO, BP 30 98713 Papeete, Tahiti, Polynésie Française.

Ciguatoxins (CTXs) are lipid-soluble polyether compounds produced by dinoflagellates from the genus Gambierdiscus spp. typically found in tropical and subtropical zones. This endemic area is however rapidly expanding due to environmental perturbations, and both toxic Gambierdiscus spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2017.12.022DOI Listing
April 2018
10 Reads
4.373 Impact Factor

Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters.

Mar Drugs 2018 Jan 1;16(1). Epub 2018 Jan 1.

Climate Change Cluster, University of Technology Sydney, P.O. Box 123 Broadway, Sydney, NSW 2007, Australia.

Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus . Here, we describe the identity and toxicology of spp. isolated from the tropical and temperate waters of eastern Australia. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1660-3397/16/1/7
Publisher Site
http://dx.doi.org/10.3390/md16010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793055PMC
January 2018
20 Reads

Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia).

Toxins (Basel) 2017 12 21;10(1). Epub 2017 Dec 21.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia.

Ciguatera fish poisoning (CFP) is a foodborne disease caused by the consumption of seafood (fish and marine invertebrates) contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the genus . The report of a CFP-like mass-poisoning outbreak following the consumption of (Tegulidae, Gastropod) from Anaho Bay on Nuku Hiva Island (Marquesas archipelago, French Polynesia) prompted field investigations to assess the presence of CTXs in . Samples were collected from Anaho Bay, 1, 6 and 28 months after this poisoning outbreak, as well as in Taiohae and Taipivai bays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins10010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793089PMC
December 2017
14 Reads

Management of Ciguatoxin Risk in Eastern Australia.

Toxins (Basel) 2017 11 14;9(11). Epub 2017 Nov 14.

NSW Food Authority, 6 Avenue of the Americas, Newington, NSW 2127, Australia.

Between 2014 and 2016, five cases of ciguatera fish poisoning (CFP), involving twenty four individuals, were linked to Spanish Mackerel () caught in the coastal waters of the state of New South Wales (NSW) on the east coast of Australia. Previously, documented cases of CFP in NSW were few, and primarily linked to fish imported from other regions. Since 2015, thirteen individuals were affected across four additional CFP cases in NSW, linked to fish imported from tropical locations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins9110367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705982PMC
November 2017
12 Reads

Ciguatoxicity of Gambierdiscus and Fukuyoa species from the Caribbean and Gulf of Mexico.

PLoS One 2017 18;12(10):e0185776. Epub 2017 Oct 18.

Ocean Tester, LLC, Beaufort, North Carolina, United States of America.

Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646788PMC
October 2017
13 Reads

The prevalence of benthic dinoflagellates associated with ciguatera fish poisoning in the central Red Sea.

Harmful Algae 2017 09 9;68:206-216. Epub 2017 Sep 9.

Red Sea Research Center, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah, 23955, Kingdom of Saudi Arabia.

This study confirms the presence of the toxigenic benthic dinoflagellates Gambierdiscus belizeanus and Ostreopsis spp. in the central Red Sea. To our knowledge, this is also the first report of these taxa in coastal waters of Saudi Arabia, indicating the potential occurrence of ciguatera fish poisoning (CFP) in that region. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2017.08.005DOI Listing
September 2017
90 Reads

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.

Bioorg Med Chem Lett 2017 10 9;27(20):4630-4634. Epub 2017 Sep 9.

Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, HI 96720, United States; Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address:

Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. The structures of compounds 1 and 2 were characterized based on MS spectroscopic and NMR analysis, and DP4+ calculations. The absolute configuration (AC) of compound 1 was determined by comparison of its optical rotation with those reported in literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2017.09.021DOI Listing
October 2017
26 Reads

Identification of ciguatoxins in a shark involved in a fatal food poisoning in the Indian Ocean.

Sci Rep 2017 08 15;7(1):8240. Epub 2017 Aug 15.

HYDROREUNION, CBEM, C/O CYROI, 2, Rue Maxime Rivière, 97490, Sainte Clotilde, La Réunion, France.

Severe food poisoning events after the consumption of sharks have been reported since the 1940s; however, there has been no clear understanding of their cause. Herein, we report for the first time the presence of ciguatoxins (CTXs) in sharks. The identification by mass spectrometry of CTXs, including two new analogues, in a bull shark (Carcharhinus leucas) that was consumed by humans, causing the poisoning and death of 11 people in Madagascar in 2013 is described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-08682-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557899PMC
August 2017
14 Reads

Taxonomic assignment of the benthic toxigenic dinoflagellate Gambierdiscus sp. type 6 as Gambierdiscus balechii (Dinophyceae), including its distribution and ciguatoxicity.

Harmful Algae 2017 07 12;67:107-118. Epub 2017 Jul 12.

Key Laboratory of Marine Ecosystem and Biogeochemistry, The Second Institute of Oceanography, SOA, Hangzhou 310012, China; Shenzhen Key Laboratory in Sustainable Use of Marine Biodiversity, Research Centre for the Oceans and Human Health, City University of Hong Kong, Shenzhen, China. Electronic address:

Recent molecular phylogenetic studies of Gambierdiscus species flagged several new species and genotypes, thus leading to revitalizing its systematics. The inter-relationships of clades revealed by the primary sequence information of nuclear ribosomal genes (rDNA), however, can sometimes be equivocal, and therefore, in this study, the taxonomic status of a ribotype, Gambierdiscus sp. type 6, was evaluated using specimens collected from the original locality, Marakei Island, Republic of Kiribati; and specimens found in Rawa Island, Peninsular Malaysia, were further used for comparison. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2017.07.002DOI Listing
July 2017
24 Reads

The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

Mar Drugs 2017 Jul 11;15(7). Epub 2017 Jul 11.

AgResearch, Ruakura Research Centre, 10 Bisley Road, Private Bag 3240, Hamilton 3214, New Zealand.

Species in the genus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kermadec Islands), and the opportunity was taken to sample for at the more southerly Macauley Island during an expedition in 2016. cells were isolated, cultured, and DNA extracted and sequenced to determine the species present. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/md15070219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532661PMC
July 2017
21 Reads

Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus.

Mar Drugs 2017 Jul 11;15(7). Epub 2017 Jul 11.

Ifremer, Phycotoxins Laboratory, rue de l'Ile d'Yeu, BP 21105, F-44311 Nantes, France.

Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera and and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, the newly described species from the Canary Islands, , is one of the most maitotoxic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/md15070220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532662PMC
July 2017
75 Reads
2.853 Impact Factor

Regional Variations in the Risk and Severity of Ciguatera Caused by Eating Moray Eels.

Authors:
Thomas Y K Chan

Toxins (Basel) 2017 06 26;9(7). Epub 2017 Jun 26.

Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Moray eels ( species) from tropical waters have long been known to be high-risk species, and the consumption of particularly the viscera or ungutted eels can result in severe ciguatera (known as or moray eel poisoning), characterized by prominent neurological features. In this review, the main objective was to describe the risk and severity of ciguatera caused by eating moray eels in different parts of the world. Moray eels can accumulate very high ciguatoxin (CTX) levels in the flesh and particularly the liver. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins9070201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535148PMC
June 2017
8 Reads

Ciguatoxins and Maitotoxins in Extracts of Sixteen Gambierdiscus Isolates and One Fukuyoa Isolate from the South Pacific and Their Toxicity to Mice by Intraperitoneal and Oral Administration.

Mar Drugs 2017 Jun 30;15(7). Epub 2017 Jun 30.

Cawthron Institute, Halifax Street Campus, Private Bag 2, Nelson 7042, New Zealand.

Ciguatoxins (CTXs), and possibly maitotoxins (MTXs), are responsible for Ciguatera Fish Poisoning, an important health problem for consumers of reef fish (such as inhabitants of islands in the South Pacific Ocean). The habitational range of the species is expanding, and new species are being discovered. In order to provide information on the potential health risk of the species, and one species (found in the Cook Islands, the Kermadec Islands, mainland New Zealand, and New South Wales, Australia), 17 microalgae isolates were collected from these areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/md15070208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532650PMC
June 2017
41 Reads

LSU rDNA based RFLP assays for the routine identification of Gambierdiscus species.

Harmful Algae 2017 06 18;66:20-28. Epub 2017 May 18.

Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.

The Gambierdiscus genus is a group of benthic dinoflagellates commonly associated with ciguatera fish poisoning (CFP), which is generally found in tropical or sub-tropical regions around the world. Morphologically similar species within the genus can vary in toxicity; however, species identifications are difficult or sometimes impossible using light microscopy. DNA sequencing of ribosomal RNA genes (rDNA) is thus often used to identify and describe Gambierdiscus species and ribotypes, but the expense and time can be prohibitive for routine culture screening and/or large-scale monitoring programs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2017.04.009DOI Listing
June 2017
51 Reads

How the marine biotoxins affect human health.

Nat Prod Res 2018 Mar 22;32(6):621-631. Epub 2017 May 22.

a Department of Chemical, Biological, Pharmaceutical and Environmental Sciences , University of Messina , Messina , Italy.

Several marine microalgae produce dangerous toxins very damaging to human health, aquatic ecosystems and coastal resources. These Harmful Algal Blooms (HABs) in recent decades seem greatly increased regarding frequency, severity and biogeographical level, causing serious health risks as a consequence of the consumption of contaminated seafood. Toxins can cause various clinically described syndromes, characterised by a wide range of symptoms: amnesic (ASP), diarrhoetic (DSP), azaspirazid (AZP), neurotoxic (NSP) and paralytic (PSP) shellfish poisonings and ciguatera fish poisoning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2017.1329734DOI Listing
March 2018
23 Reads

Human neuronal cell based assay: A new in vitro model for toxicity evaluation of ciguatoxin.

Environ Toxicol Pharmacol 2017 Jun 14;52:200-213. Epub 2017 Apr 14.

Laboratory of Clinical and Experimental Toxicology, Poison Control Centre, Toxicology Unit, Maugeri Clinical Scientific Institutes S.p.A.-BS, IRCCS Pavia, Pavia Italy.

Ciguatoxins (CTXs) are emerging marine neurotoxins representing the main cause of ciguatera fish poisoning, an intoxication syndrome which configures a health emergency and constitutes an evolving issue constantly changing due to new vectors and derivatives of CTXs, as well as their presence in new non-endemic areas. The study applied the neuroblastoma cell model of human origin (SH-SY5Y) to evaluate species-specific mechanistic information on CTX toxicity. Metabolic functionality, cell morphology, cytosolic Ca responses, neuronal cell growth and proliferation were assessed after short- (4-24h) and long-term exposure (10days) to P-CTX-3C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.etap.2017.04.003DOI Listing
June 2017
9 Reads

Toxicity screening of 13 Gambierdiscus strains using neuro-2a and erythrocyte lysis bioassays.

Harmful Algae 2017 03 9;63:173-183. Epub 2017 Mar 9.

Ifremer, Phycotoxins Laboratory, rue de l'Ile d'Yeu, BP 21105, F-44311 Nantes, France.

Species in the epi-benthic dinoflagellate genus Gambierdiscus produce ciguatoxins (CTXs) and maitotoxins (MTXs), which are among the most potent marine toxins known. Consumption of fish contaminated with sufficient quantities of CTXs causes Ciguatera Fish Poisoning (CFP), the largest cause of non-bacterial food poisoning worldwide. Maitotoxins, which can be found in the digestive system of fish, could also contribute to CFP if such tissues are consumed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hal.2017.02.005DOI Listing
March 2017
59 Reads
3.874 Impact Factor

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management.

Mar Drugs 2017 Mar 14;15(3). Epub 2017 Mar 14.

European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall Tr1 3HD, UK.

Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/md15030072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367029PMC
March 2017
23 Reads