205 results match your criteria Toxicity Ciguatera


A radioligand receptor binding assay for ciguatoxin monitoring in environmental samples: Method development and determination of quality control criteria.

J Environ Radioact 2018 Dec 9;192:289-294. Epub 2018 Jul 9.

Environment Laboratories, Department of Nuclear Science and Application, International Atomic Energy Agency, 98000, Monaco. Electronic address:

Ciguatoxins are algal toxins responsible for tens of thousands of human intoxications yearly, both in tropical and subtropical endemic regions as well as worldwide through fish exportation. Previously developed methods for biotoxin surveillance in the environment and seafood include analytical methods and in vivo and in vitro bioassays. The radioligand receptor binding assay (r-RBA) is among the in vitro methodologies currently used for the detection and quantification of marine biotoxins. Read More

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http://dx.doi.org/10.1016/j.jenvrad.2018.06.019DOI Listing
December 2018
6 Reads

Growth and Toxin Production of spp. Can Be Regulated by Quorum-Sensing Bacteria.

Toxins (Basel) 2018 Jun 22;10(7). Epub 2018 Jun 22.

Shenzhen Public Platform of Screening & Application of Marine Microbial Resources, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

spp. are the major culprit responsible for global ciguatera fish poisoning (CFP). At present, the effects of microbiological factors on algal proliferation and toxin production are poorly understood. Read More

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http://dx.doi.org/10.3390/toxins10070257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071102PMC
June 2018
5 Reads
2.480 Impact Factor

Investigation of ciguatoxins in invasive lionfish from the greater caribbean region: Implications for fishery development.

PLoS One 2018 20;13(6):e0198358. Epub 2018 Jun 20.

National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America.

Lionfish, native to reef ecosystems of the tropical and sub-tropical Indo-Pacific, were introduced to Florida waters in the 1980s, and have spread rapidly throughout the northwestern Atlantic, Caribbean Sea and the Gulf of Mexico. These invasive, carnivorous fish significantly reduce other fish and benthic invertebrate biomass, fish recruitment, and species richness in reef ecosystems. Fisheries resource managers have proposed the establishment of a commercial fishery to reduce lionfish populations and mitigate adverse effects on reef communities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198358PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010213PMC
December 2018
24 Reads

Seasonal distribution of Gambierdiscus spp. in Wakasa Bay, the Sea of Japan, and antagonistic relationships with epiphytic pennate diatoms.

Harmful Algae 2018 Jun 19;76:58-65. Epub 2018 May 19.

Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.

The occurrence of the ciguatera fish poisoning (CFP) causative Gambierdiscus spp. was confirmed in the Sea of Japan for the first time in 2009. This paper reports seasonal distribution of Gambierdiscus spp. Read More

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http://dx.doi.org/10.1016/j.hal.2018.05.002DOI Listing
June 2018
8 Reads

Experimental evidence of dietary ciguatoxin accumulation in an herbivorous coral reef fish.

Aquat Toxicol 2018 Jul 26;200:257-265. Epub 2018 May 26.

International Atomic Energy Agency, IAEA Environment Laboratories, 4 Quai Antoine 1er, 98000, Monaco, Monaco. Electronic address:

Ciguatoxins (CTXs) are potent algal toxins that cause widespread ciguatera poisoning and are found ubiquitously in coral reef food webs. Here we developed an environmentally-relevant, experimental model of CTX trophic transfer involving dietary exposure of herbivorous fish to the CTX-producing microalgae Gambierdiscus polynesiensis. Juvenile Naso brevirostris were fed a gel-food embedded with microalgae for 16 weeks (89 cells g fish daily, 0. Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.05.007DOI Listing
July 2018
7 Reads
3.451 Impact Factor

Differential toxin profiles of ciguatoxins in marine organisms: Chemistry, fate and global distribution.

Toxicon 2018 Aug 17;150:124-143. Epub 2018 May 17.

IPMA - Instituto Português do Mar e da Atmosfera, Rua Alfredo Magalhães Ramalho, 6, 1495-006, Lisbon, Portugal; CCMAR - Centre of Marine Sciences, University of Algarve, Campus of Gambelas, 8005-139, Faro, Portugal. Electronic address:

Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affect up to 500,000 people annually due to fish consumption. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.05.005DOI Listing
August 2018
2 Reads

Highly Sensitive and Practical Fluorescent Sandwich ELISA for Ciguatoxins.

Anal Chem 2018 Jun 29;90(12):7318-7324. Epub 2018 May 29.

Department of Biological Science, Graduate School of Science , Osaka Prefecture University , Osaka 599-8570 , Japan.

Ciguatera fish poisoning (CFP) caused by the consumption of fish that have accumulated ciguatoxins (CTXs) affects more than 50000 people annually. The spread of CFP causes enormous damage to public health, fishery resources, and the economies of tropical and subtropical endemic regions. The difficulty in avoiding CFP arises from the lack of sensitive and reliable analytical methods for the detection and quantification of CTXs in contaminated fish, along with the normal appearance, smell, and taste of fish contaminated with the causative toxins. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b00519DOI Listing
June 2018
3 Reads

Tissue Distribution and Elimination of Ciguatoxins in (, Bivalvia) Fed .

Toxins (Basel) 2018 May 10;10(5). Epub 2018 May 10.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, PO Box 30, 98713 Papeete, Tahiti, French Polynesia.

Ciguatera is a foodborne disease caused by the consumption of seafood contaminated with ciguatoxins (CTXs). Ciguatera-like poisoning events involving giant clams () are reported occasionally from Pacific islands communities. The present study aimed at providing insights into CTXs tissue distribution and detoxification rate in giant clams exposed to toxic cells of , in the framework of seafood safety assessment. Read More

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http://dx.doi.org/10.3390/toxins10050189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983245PMC
May 2018
6 Reads
2.480 Impact Factor

Phylogeny, morphology and toxicity of benthic dinoflagellates of the genus Fukuyoa (Goniodomataceae, Dinophyceae) from a subtropical reef ecosystem in the South China Sea.

Harmful Algae 2018 Apr 17;74:78-97. Epub 2018 Apr 17.

State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China. Electronic address:

Species of Fukuyoa, recently revised from the globular Gambierdiscus, are toxic benthic dinoflagellates associated with ciguatera. In this study, a total of ten strains of Fukuyoa collected from Hong Kong waters were characterized using morphological and phylogenetic analyses. Results from both analyses showed that one of the strains is a putative new species, namely Fukuyoa sp. Read More

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http://dx.doi.org/10.1016/j.hal.2018.03.003DOI Listing
April 2018
42 Reads

Toxicological Investigations on the Sea Urchin Tripneustes gratilla (Toxopneustidae, Echinoid) from Anaho Bay (Nuku Hiva, French Polynesia): Evidence for the Presence of Pacific Ciguatoxins.

Mar Drugs 2018 Apr 6;16(4). Epub 2018 Apr 6.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, PO Box 30, 98713 Papeete, Tahiti, French Polynesia.

The sea urchin (, Echinoids) is a source of protein for many islanders in the Indo-West Pacific. It was previously reported to occasionally cause ciguatera-like poisoning; however, the exact nature of the causative agent was not confirmed. In April and July 2015, ciguatera poisonings were reported following the consumption of in Anaho Bay (Nuku Hiva Island, Marquesas archipelago, French Polynesia). Read More

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http://dx.doi.org/10.3390/md16040122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923409PMC
April 2018
4 Reads
2.853 Impact Factor

Immune effects of the neurotoxins ciguatoxins and brevetoxins.

Toxicon 2018 Jul 31;149:6-19. Epub 2018 Jan 31.

Laboratory of Interactions Keratinocytes-Neurons, University of Western Brittany, 22 Avenue Camille Desmoulins, 29200 Brest, France. Electronic address:

Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain, pruritus and cold dysaesthesia), which can persist several weeks and, in some cases, several months or years. NSP is considered a mild form of CFP with similar but less severe symptoms. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.01.002DOI Listing
July 2018
6 Reads

Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters.

Mar Drugs 2018 Jan 1;16(1). Epub 2018 Jan 1.

Climate Change Cluster, University of Technology Sydney, P.O. Box 123 Broadway, Sydney, NSW 2007, Australia.

Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus . Here, we describe the identity and toxicology of spp. isolated from the tropical and temperate waters of eastern Australia. Read More

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http://www.mdpi.com/1660-3397/16/1/7
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http://dx.doi.org/10.3390/md16010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793055PMC
January 2018
11 Reads

Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia).

Toxins (Basel) 2017 12 21;10(1). Epub 2017 Dec 21.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae-UMR 241-EIO, P.O. Box 30, 98713 Papeete, Tahiti, French Polynesia.

Ciguatera fish poisoning (CFP) is a foodborne disease caused by the consumption of seafood (fish and marine invertebrates) contaminated with ciguatoxins (CTXs) produced by dinoflagellates in the genus . The report of a CFP-like mass-poisoning outbreak following the consumption of (Tegulidae, Gastropod) from Anaho Bay on Nuku Hiva Island (Marquesas archipelago, French Polynesia) prompted field investigations to assess the presence of CTXs in . Samples were collected from Anaho Bay, 1, 6 and 28 months after this poisoning outbreak, as well as in Taiohae and Taipivai bays. Read More

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http://dx.doi.org/10.3390/toxins10010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793089PMC
December 2017
6 Reads

Management of Ciguatoxin Risk in Eastern Australia.

Toxins (Basel) 2017 11 14;9(11). Epub 2017 Nov 14.

NSW Food Authority, 6 Avenue of the Americas, Newington, NSW 2127, Australia.

Between 2014 and 2016, five cases of ciguatera fish poisoning (CFP), involving twenty four individuals, were linked to Spanish Mackerel () caught in the coastal waters of the state of New South Wales (NSW) on the east coast of Australia. Previously, documented cases of CFP in NSW were few, and primarily linked to fish imported from other regions. Since 2015, thirteen individuals were affected across four additional CFP cases in NSW, linked to fish imported from tropical locations. Read More

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http://dx.doi.org/10.3390/toxins9110367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705982PMC
November 2017
6 Reads

Ciguatoxicity of Gambierdiscus and Fukuyoa species from the Caribbean and Gulf of Mexico.

PLoS One 2017 18;12(10):e0185776. Epub 2017 Oct 18.

Ocean Tester, LLC, Beaufort, North Carolina, United States of America.

Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646788PMC
October 2017
5 Reads

The prevalence of benthic dinoflagellates associated with ciguatera fish poisoning in the central Red Sea.

Harmful Algae 2017 09 9;68:206-216. Epub 2017 Sep 9.

Red Sea Research Center, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Jeddah, 23955, Kingdom of Saudi Arabia.

This study confirms the presence of the toxigenic benthic dinoflagellates Gambierdiscus belizeanus and Ostreopsis spp. in the central Red Sea. To our knowledge, this is also the first report of these taxa in coastal waters of Saudi Arabia, indicating the potential occurrence of ciguatera fish poisoning (CFP) in that region. Read More

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http://dx.doi.org/10.1016/j.hal.2017.08.005DOI Listing
September 2017
57 Reads

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.

Bioorg Med Chem Lett 2017 10 9;27(20):4630-4634. Epub 2017 Sep 9.

Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, HI 96720, United States; Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address:

Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. The structures of compounds 1 and 2 were characterized based on MS spectroscopic and NMR analysis, and DP4+ calculations. The absolute configuration (AC) of compound 1 was determined by comparison of its optical rotation with those reported in literature. Read More

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http://dx.doi.org/10.1016/j.bmcl.2017.09.021DOI Listing
October 2017
13 Reads

Taxonomic assignment of the benthic toxigenic dinoflagellate Gambierdiscus sp. type 6 as Gambierdiscus balechii (Dinophyceae), including its distribution and ciguatoxicity.

Harmful Algae 2017 07 12;67:107-118. Epub 2017 Jul 12.

Key Laboratory of Marine Ecosystem and Biogeochemistry, The Second Institute of Oceanography, SOA, Hangzhou 310012, China; Shenzhen Key Laboratory in Sustainable Use of Marine Biodiversity, Research Centre for the Oceans and Human Health, City University of Hong Kong, Shenzhen, China. Electronic address:

Recent molecular phylogenetic studies of Gambierdiscus species flagged several new species and genotypes, thus leading to revitalizing its systematics. The inter-relationships of clades revealed by the primary sequence information of nuclear ribosomal genes (rDNA), however, can sometimes be equivocal, and therefore, in this study, the taxonomic status of a ribotype, Gambierdiscus sp. type 6, was evaluated using specimens collected from the original locality, Marakei Island, Republic of Kiribati; and specimens found in Rawa Island, Peninsular Malaysia, were further used for comparison. Read More

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http://dx.doi.org/10.1016/j.hal.2017.07.002DOI Listing
July 2017
13 Reads

The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

Mar Drugs 2017 Jul 11;15(7). Epub 2017 Jul 11.

AgResearch, Ruakura Research Centre, 10 Bisley Road, Private Bag 3240, Hamilton 3214, New Zealand.

Species in the genus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kermadec Islands), and the opportunity was taken to sample for at the more southerly Macauley Island during an expedition in 2016. cells were isolated, cultured, and DNA extracted and sequenced to determine the species present. Read More

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http://dx.doi.org/10.3390/md15070219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532661PMC
July 2017
10 Reads

Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus.

Mar Drugs 2017 Jul 11;15(7). Epub 2017 Jul 11.

Ifremer, Phycotoxins Laboratory, rue de l'Ile d'Yeu, BP 21105, F-44311 Nantes, France.

Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera and and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, the newly described species from the Canary Islands, , is one of the most maitotoxic. Read More

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http://dx.doi.org/10.3390/md15070220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532662PMC
July 2017
37 Reads
2.853 Impact Factor

Regional Variations in the Risk and Severity of Ciguatera Caused by Eating Moray Eels.

Authors:
Thomas Y K Chan

Toxins (Basel) 2017 06 26;9(7). Epub 2017 Jun 26.

Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Moray eels ( species) from tropical waters have long been known to be high-risk species, and the consumption of particularly the viscera or ungutted eels can result in severe ciguatera (known as or moray eel poisoning), characterized by prominent neurological features. In this review, the main objective was to describe the risk and severity of ciguatera caused by eating moray eels in different parts of the world. Moray eels can accumulate very high ciguatoxin (CTX) levels in the flesh and particularly the liver. Read More

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http://dx.doi.org/10.3390/toxins9070201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535148PMC
June 2017
1 Read

Ciguatoxins and Maitotoxins in Extracts of Sixteen Gambierdiscus Isolates and One Fukuyoa Isolate from the South Pacific and Their Toxicity to Mice by Intraperitoneal and Oral Administration.

Mar Drugs 2017 Jun 30;15(7). Epub 2017 Jun 30.

Cawthron Institute, Halifax Street Campus, Private Bag 2, Nelson 7042, New Zealand.

Ciguatoxins (CTXs), and possibly maitotoxins (MTXs), are responsible for Ciguatera Fish Poisoning, an important health problem for consumers of reef fish (such as inhabitants of islands in the South Pacific Ocean). The habitational range of the species is expanding, and new species are being discovered. In order to provide information on the potential health risk of the species, and one species (found in the Cook Islands, the Kermadec Islands, mainland New Zealand, and New South Wales, Australia), 17 microalgae isolates were collected from these areas. Read More

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http://dx.doi.org/10.3390/md15070208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532650PMC
June 2017
17 Reads

LSU rDNA based RFLP assays for the routine identification of Gambierdiscus species.

Harmful Algae 2017 06 18;66:20-28. Epub 2017 May 18.

Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.

The Gambierdiscus genus is a group of benthic dinoflagellates commonly associated with ciguatera fish poisoning (CFP), which is generally found in tropical or sub-tropical regions around the world. Morphologically similar species within the genus can vary in toxicity; however, species identifications are difficult or sometimes impossible using light microscopy. DNA sequencing of ribosomal RNA genes (rDNA) is thus often used to identify and describe Gambierdiscus species and ribotypes, but the expense and time can be prohibitive for routine culture screening and/or large-scale monitoring programs. Read More

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http://dx.doi.org/10.1016/j.hal.2017.04.009DOI Listing
June 2017
18 Reads

How the marine biotoxins affect human health.

Nat Prod Res 2018 Mar 22;32(6):621-631. Epub 2017 May 22.

a Department of Chemical, Biological, Pharmaceutical and Environmental Sciences , University of Messina , Messina , Italy.

Several marine microalgae produce dangerous toxins very damaging to human health, aquatic ecosystems and coastal resources. These Harmful Algal Blooms (HABs) in recent decades seem greatly increased regarding frequency, severity and biogeographical level, causing serious health risks as a consequence of the consumption of contaminated seafood. Toxins can cause various clinically described syndromes, characterised by a wide range of symptoms: amnesic (ASP), diarrhoetic (DSP), azaspirazid (AZP), neurotoxic (NSP) and paralytic (PSP) shellfish poisonings and ciguatera fish poisoning. Read More

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http://dx.doi.org/10.1080/14786419.2017.1329734DOI Listing
March 2018
7 Reads

Human neuronal cell based assay: A new in vitro model for toxicity evaluation of ciguatoxin.

Environ Toxicol Pharmacol 2017 Jun 14;52:200-213. Epub 2017 Apr 14.

Laboratory of Clinical and Experimental Toxicology, Poison Control Centre, Toxicology Unit, Maugeri Clinical Scientific Institutes S.p.A.-BS, IRCCS Pavia, Pavia Italy.

Ciguatoxins (CTXs) are emerging marine neurotoxins representing the main cause of ciguatera fish poisoning, an intoxication syndrome which configures a health emergency and constitutes an evolving issue constantly changing due to new vectors and derivatives of CTXs, as well as their presence in new non-endemic areas. The study applied the neuroblastoma cell model of human origin (SH-SY5Y) to evaluate species-specific mechanistic information on CTX toxicity. Metabolic functionality, cell morphology, cytosolic Ca responses, neuronal cell growth and proliferation were assessed after short- (4-24h) and long-term exposure (10days) to P-CTX-3C. Read More

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http://dx.doi.org/10.1016/j.etap.2017.04.003DOI Listing
June 2017
2 Reads

Toxicity screening of 13 Gambierdiscus strains using neuro-2a and erythrocyte lysis bioassays.

Harmful Algae 2017 03 9;63:173-183. Epub 2017 Mar 9.

Ifremer, Phycotoxins Laboratory, rue de l'Ile d'Yeu, BP 21105, F-44311 Nantes, France.

Species in the epi-benthic dinoflagellate genus Gambierdiscus produce ciguatoxins (CTXs) and maitotoxins (MTXs), which are among the most potent marine toxins known. Consumption of fish contaminated with sufficient quantities of CTXs causes Ciguatera Fish Poisoning (CFP), the largest cause of non-bacterial food poisoning worldwide. Maitotoxins, which can be found in the digestive system of fish, could also contribute to CFP if such tissues are consumed. Read More

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http://dx.doi.org/10.1016/j.hal.2017.02.005DOI Listing
March 2017
30 Reads
3.874 Impact Factor

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management.

Mar Drugs 2017 Mar 14;15(3). Epub 2017 Mar 14.

European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall Tr1 3HD, UK.

Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. Read More

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http://dx.doi.org/10.3390/md15030072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367029PMC
March 2017
11 Reads

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Sci Rep 2017 02 22;7:42810. Epub 2017 Feb 22.

Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd, St Lucia, Queensland 4072, Australia.

Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (Na), causes ciguatera, a disease characterised by gastrointestinal and neurological disturbances. We assessed the activity of the most potent congener, Pacific ciguatoxin-1 (P-CTX-1), on Na1.1-1. Read More

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http://dx.doi.org/10.1038/srep42810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320492PMC
February 2017
9 Reads

Developmental toxicity and molecular responses of marine medaka (Oryzias melastigma) embryos to ciguatoxin P-CTX-1 exposure.

Aquat Toxicol 2017 Apr 10;185:149-159. Epub 2017 Feb 10.

State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong, China; Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity, Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China. Electronic address:

Ciguatoxins are produced by toxic benthic dinoflagellates and cause ciguatera fish poisoning worldwide, but the toxic effects on developing marine fish have not been well investigated. The Pacific ciguatoxin (P-CTX-1), is a potent sodium channel agonist, which is one of the most toxic members among all CTXs. This study evaluated the toxic effects of microinjecting purified Pacific ciguatoxin-1 (P-CTX-1) on embryonic development of marine medaka Oryzias melastigma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X173003
Publisher Site
http://dx.doi.org/10.1016/j.aquatox.2017.02.006DOI Listing
April 2017
20 Reads

A new Gambierdiscus species (Dinophyceae) from Rarotonga, Cook Islands: Gambierdiscus cheloniae sp. nov.

Harmful Algae 2016 12 2;60:45-56. Epub 2016 Nov 2.

Plant Functional Biology and Climate Change Cluster, University of Technology Sydney, PO Box 123, Broadway, New South Wales 2007, Australia; Sydney Institute of Marine Sciences, Chowder Bay Rd, Mosman 2088, New South Wales Australia.

Ciguatera fish poisoning (CFP) has been reported for many years in Rarotonga, Cook Islands, and has had the world's highest reported incidence of this illness for the last 20 years. Following intensive sampling to understand the distribution of the causative organisms of CFP, an undescribed Gambierdiscus species was isolated from the Rarotongan lagoon. Gambierdiscus cheloniae sp. Read More

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http://dx.doi.org/10.1016/j.hal.2016.10.006DOI Listing
December 2016
6 Reads

Quantitative PCR assay for detection and enumeration of ciguatera-causing dinoflagellate Gambierdiscus spp. (Gonyaulacales) in coastal areas of Japan.

Harmful Algae 2016 02 28;52:11-22. Epub 2015 Dec 28.

LAQUES (Laboratory of Aquatic Environmental Science), Faculty of Agriculture, Kochi University, 200 Otsu, Monobe, Nankoku, Kochi, 783-8502, Japan. Electronic address:

In Japan, ciguatera fish poisoning (CFP) has been increasingly reported not only in subtropical areas but also in temperate areas in recent years, causing a serious threat to human health. Ciguatera fish poisoning is caused by the consumption of fish that have accumulated toxins produced by an epiphytic/benthic dinoflagellate, genus Gambierdiscus. Previous studies revealed the existence of five Gambierdiscus species/phylotypes in Japan: Gambierdiscus australes, Gambierdiscus scabrosus, Gambierdiscus sp. Read More

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http://dx.doi.org/10.1016/j.hal.2015.11.018DOI Listing
February 2016
12 Reads

Gambierdiscus balechii sp. nov (Dinophyceae), a new benthic toxic dinoflagellate from the Celebes Sea (SW Pacific Ocean).

Harmful Algae 2016 09 28;58:93-105. Epub 2016 Jun 28.

Centro Oceanográfico de Vigo, Instituto Español de Oceanografía, Subida a Radio Faro 50, 36390 Vigo, Spain. Electronic address:

A new benthic toxic dinoflagellate is described from the Celebes Sea. Gambierdiscus balechii sp. nov. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15689883163017
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http://dx.doi.org/10.1016/j.hal.2016.06.004DOI Listing
September 2016
3 Reads

Characterization of Gambierdiscus lapillus sp. nov. (Gonyaulacales, Dinophyceae): a new toxic dinoflagellate from the Great Barrier Reef (Australia).

J Phycol 2017 04 30;53(2):283-297. Epub 2017 Jan 30.

Climate Change Cluster (C3), University of Technology Sydney, Ultimo, New South Wales, 2007, Australia.

Gambierdiscus is a genus of benthic dinoflagellates found worldwide. Some species produce neurotoxins (maitotoxins and ciguatoxins) that bioaccumulate and cause ciguatera fish poisoning (CFP), a potentially fatal food-borne illness that is common worldwide in tropical regions. The investigation of toxigenic species of Gambierdiscus in CFP endemic regions in Australia is necessary as a first step to determine which species of Gambierdiscus are related to CFP cases occurring in this region. Read More

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http://doi.wiley.com/10.1111/jpy.12496
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http://dx.doi.org/10.1111/jpy.12496DOI Listing
April 2017
25 Reads

Acute Exposure to Pacific Ciguatoxin Reduces Electroencephalogram Activity and Disrupts Neurotransmitter Metabolic Pathways in Motor Cortex.

Mol Neurobiol 2017 09 10;54(7):5590-5603. Epub 2016 Sep 10.

Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong.

Ciguatera fish poisoning (CFP) is a common human food poisoning caused by consumption of ciguatoxin (CTX)-contaminated fish affecting over 50,000 people worldwide each year. CTXs are classified depending on their origin from the Pacific (P-CTXs), Indian Ocean (I-CTXs), and Caribbean (C-CTXs). P-CTX-1 is the most toxic CTX known and the major source of CFP causing an array of neurological symptoms. Read More

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http://dx.doi.org/10.1007/s12035-016-0093-yDOI Listing
September 2017
5 Reads

Evidence of the bioaccumulation of ciguatoxins in giant clams (Tridacna maxima) exposed to Gambierdiscus spp. cells.

Harmful Algae 2016 Jul 23;57(Pt A):78-87. Epub 2016 Jun 23.

Institut Louis Malardé (ILM), Laboratory of Toxic Microalgae - UMR 241-EIO, PO Box 30, 98713 Papeete, Tahiti, French Polynesia.

Ciguatera Fish Poisoning (CFP) is a foodborne disease classically related to the consumption of tropical coral reef fishes contaminated with ciguatoxins (CTXs), neurotoxins produced by dinoflagellates of the Gambierdiscus genus. Severe atypical ciguatera-like incidents involving giant clams, a marine resource highly consumed in the South Pacific, are also frequently reported in many Pacific Islands Countries and Territories. The present study was designed to assess the ability of giant clams to accumulate CTXs in their tissues and highlight the potential health risks associated with their consumption. Read More

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http://dx.doi.org/10.1016/j.hal.2016.05.007DOI Listing
July 2016
2 Reads

Communities advancing the studies of Tribal nations across their lifespan: Design, methods, and baseline of the CoASTAL cohort.

Harmful Algae 2016 07 30;57(Pt B):9-19. Epub 2016 Aug 30.

Department of Neurology: Division of Neuropsychology, University of Maryland School of Medicine, 110 S. Paca St. 3rd Floor, Baltimore, MD 21201, USA. Electronic address:

The CoASTAL cohort represents the first community cohort assembled to study a HAB-related illness. It is comprised of three Native American tribes in the Pacific NW for the purpose of studying the health impacts of chronic, low level domoic acid (DA) exposure through razor clam consumption. This cohort is at risk of DA toxicity by virtue of their geographic location (access to beaches with a history of elevated DA levels in razor clams) and the cultural and traditional significance of razor clams in their diet. Read More

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http://dx.doi.org/10.1016/j.hal.2016.03.010DOI Listing
July 2016
3 Reads

Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury.

Sci Rep 2016 05 27;6:26809. Epub 2016 May 27.

Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Hong Kong.

Ciguatera fish poisoning (CFP) results from consumption of tropical reef fish containing ciguatoxins (CTXs). Pacific (P)-CTX-1 is among the most potent known CTXs and the predominant source of CFP in the endemic region responsible for the majority of neurological symptoms in patients. Chronic and persistent neurological symptoms occur in some CFP patients, which often result in incomplete functional recovery for years. Read More

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http://dx.doi.org/10.1038/srep26809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882531PMC
May 2016
8 Reads

Invasive Lionfish (Pterosis volitans) Pose Public Health Threats.

Authors:
James H Diaz

J La State Med Soc 2015 Jul-Aug;167(4):166-71. Epub 2015 Aug 15.

Louisiana State University Health Sciences Center in New Orleans.

The lionfish, Pterosis volitans, a native of Indo-Pacific oceans, is a popular saltwater aquarium fish despite venomous spines on its fins. Lionfish were inadvertently introduced into the western Atlantic from Florida in the early 1990s and have overpopulated and dispersed widely into the Caribbean Sea and Gulf of Mexico. Initiatives to control lionfish populations were launched, including the National Oceanographic and Atmospheric Administration (NOAA)-sponsored "Lionfish as Food Campaign". Read More

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September 2017
4 Reads

Clinical diagnosis and chemical confirmation of ciguatera fish poisoning in New South Wales, Australia.

Commun Dis Intell Q Rep 2016 Mar 31;40(1):E1-6. Epub 2016 Mar 31.

, North Coast Public Health Unit, Lismore, New South Wales.

Ciguatera fish poisoning is common in tropical and sub-tropical areas and larger fish (> 10 kg) are more susceptible to toxin accumulation with age. Although the coastal climate of northern New South Wales is considered sub-tropical, prior to 2014 there has only been 1 documented outbreak of ciguatera fish poisoning from fish caught in the region. During February and March 2014, 2 outbreaks of ciguatera fish poisoning involved 4 and 9 individuals, respectively, both following consumption of Spanish mackerel from northern New South Wales coastal waters (Evans Head and Scotts Head). Read More

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March 2016
8 Reads

Influence of Environmental Variables on Gambierdiscus spp. (Dinophyceae) Growth and Distribution.

PLoS One 2016 13;11(4):e0153197. Epub 2016 Apr 13.

Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America.

Benthic dinoflagellates in the genus Gambierdiscus produce the ciguatoxin precursors responsible for the occurrence of ciguatera toxicity. The prevalence of ciguatera toxins in fish has been linked to the presence and distribution of toxin-producing species in coral reef ecosystems, which is largely determined by the presence of suitable benthic habitat and environmental conditions favorable for growth. Here using single factor experiments, we examined the effects of salinity, irradiance, and temperature on growth of 17 strains of Gambierdiscus representing eight species/phylotypes (G. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830584PMC
August 2016
10 Reads

Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish.

PLoS One 2016 13;11(4):e0153348. Epub 2016 Apr 13.

National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America.

Ciguatera fish poisoning is an illness suffered by > 50,000 people yearly after consumption of fish containing ciguatoxins (CTXs). One of the current methodologies to detect ciguatoxins in fish is a radiolabeled receptor binding assay (RBA(R)). However, the license requirements and regulations pertaining to radioisotope utilization can limit the applicability of the RBA(R) in certain labs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830512PMC
September 2016
25 Reads

Characteristic Features and Contributory Factors in Fatal Ciguatera Fish Poisoning--Implications for Prevention and Public Education.

Authors:
Thomas Y K Chan

Am J Trop Med Hyg 2016 Apr 19;94(4):704-9. Epub 2016 Jan 19.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Centre for Food and Drug Safety, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

In this review, the main objective was to describe the characteristic features of fatal ciguatera fish poisoning and identify contributory factors, with a view to promote prevention and public education. Ciguatera-related deaths, although rare, have been reported from the Pacific, Caribbean, and Indian Ocean regions. The clinical features were generally dominated by convulsions and coma, with various focal neurological signs. Read More

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http://dx.doi.org/10.4269/ajtmh.15-0686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824207PMC
April 2016
27 Reads

An updated ciguatoxin extraction method and silica cleanup for use with HPLC-MS/MS for the analysis of P-CTX-1, PCTX-2 and P-CTX-3.

Toxicon 2015 Dec 2;108:249-56. Epub 2015 Nov 2.

James Cook University, Centre for Sustainable Tropical Fisheries and Aquaculture, James Cook University, James Cook Drive, Townsville, QLD 4811, Australia.

Ciguatera fish poisoning is a debilitating human neuro-intoxication caused by consumption of tropical marine organisms, contaminated with bioaccumulated ciguatoxins (CTXs). The growing number of cases coupled with the high toxicity of CTXs makes their reliable detection and quantification of paramount importance. Three commonly occurring ciguatoxins, P-CTX-1, 2 and 3 from five different ciguatoxic Spanish mackerel (Scomberomorus commerson), were used to assess the effectiveness of different extraction techniques: homogenization (high powered blending vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101153012
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http://dx.doi.org/10.1016/j.toxicon.2015.10.021DOI Listing
December 2015
9 Reads

Use of Surveillance Systems in Detection of a Ciguatera Fish Poisoning Outbreak - Orange County, Florida, 2014.

MMWR Morb Mortal Wkly Rep 2015 Oct 16;64(40):1142-4. Epub 2015 Oct 16.

What is already known on this topic? Ciguatera fish poisoning (CFP), caused by the ingestion of predatory reef-dwelling fish harboring ciguatoxins is one of the most commonly reported fish-associated marine intoxications. Ciguatoxin retains toxicity regardless of freezing or cooking. Prompt treatment can reduce debilitating neurologic symptoms that are associated with CFP. Read More

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http://dx.doi.org/10.15585/mmwr.mm6440a3DOI Listing
October 2015
16 Reads

Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera.

Eur J Neurosci 2015 Dec 13;42(11):3004-11. Epub 2015 Nov 13.

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.

Cold hypersensitivity is evident in a range of neuropathies and can evoke sensations of paradoxical burning cold pain. Ciguatoxin poisoning is known to induce a pain syndrome caused by consumption of contaminated tropical fish that can persist for months and include pruritus and cold allodynia; at present no suitable treatment is available. This study examined, for the first time, the neural substrates and molecular components of Pacific ciguatoxin-2-induced cold hypersensitivity. Read More

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http://doi.wiley.com/10.1111/ejn.13098
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http://dx.doi.org/10.1111/ejn.13098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744673PMC
December 2015
9 Reads

Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).

Environ Res 2015 Nov 26;143(Pt B):100-8. Epub 2015 Sep 26.

Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou km 5.5, Sant Carles de la Rapita, Spain.

From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the presence of ciguatoxins (CTXs) was indicated in meal remnants and in uncooked fish by the mouse bioassay (MBA). Caribbean ciguatoxins (C-CTXs) were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351153008
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http://dx.doi.org/10.1016/j.envres.2015.09.014DOI Listing
November 2015
32 Reads

First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis.

Toxins (Basel) 2015 Sep 21;7(9):3740-57. Epub 2015 Sep 21.

Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto 4619-007, Portugal.

Ciguatera fish poisoning (CFP) is a syndrome caused by the ingestion of fish contaminated with Ciguatoxins (CTXs). These phycotoxins are produced mainly by dinoflagellates that belong to the genus Gambierdiscus that are transformed in more toxic forms in predatory fish guts, and are more present in the Indo-Pacific and Caribbean areas. It is estimated that CFP causes per year more than 10,000 intoxications worldwide. Read More

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http://dx.doi.org/10.3390/toxins7093740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591666PMC
September 2015
31 Reads