2,464 results match your criteria Toxicity Chlorine Gas


Determination of adsorbable organically bound fluorine (AOF) and adsorbable organically bound halogens as sum parameters in aqueous environmental samples using combustion ion chromatography (CIC).

Sci Total Environ 2019 Apr 6;673:384-391. Epub 2019 Apr 6.

Hessian State Laboratory, Glarusstrasse 6, D-65203 Wiesbaden, Germany.

Because of their toxicity and biomagnification potential individual perfluoroalkyl and polyfluoroalkyl substances (PFAS) are regularly examined in food and environmental matrices by LC-MS/MS. The combustion ion chromatography (CIC) can be used to determine adsorbable organic fluorine (AOF) in aqueous samples. This report describes the optimization and validation of an automated, robust, cost-efficient and rapid CIC method for the determination of AOF. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.068DOI Listing

Nanobubble Technologies Offer Opportunities To Improve Water Treatment.

Acc Chem Res 2019 Apr 8. Epub 2019 Apr 8.

Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment, School of Sustainable Engineering and the Built Environment , Arizona State University , Tempe , Arizona 85287-5306 , United States.

Since first hypothesizing the existence of nanobubbles (NBs) in 1994, the empirical study of NB properties and commercialization of NB generators have rapidly evolved. NBs are stable spherical packages of gas within liquid and are operationally defined as having diameters less than 1000 nm, though they are typically in the range of 100 nm in one dimension. While theories still lack the ability to explain empirical evidence for formation of stable NBs in water, numerous NB applications have emerged in different fields, including water and wastewater purification where NBs offer the potential to replace or improve efficiency of current treatment processes. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00606DOI Listing
April 2019
3 Reads

Feasibility of the solar/chlorine treatment for lipid regulator degradation in simulated and real waters: The oxidation chemistry and affecting factors.

Chemosphere 2019 Mar 22;226:123-131. Epub 2019 Mar 22.

Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.

This work investigated the feasibility and mechanisms of solar/chlorine process in the removal of a kind of emerging contaminants, lipid regulators (gemfibrozil (GFRZ), benzafibrate (BZF), and clofibric acid (CA)), in simulated and real waters. These lipid regulators could be effectively removed by solar/chlorine treatment, and their corresponding pseudo-first-order rate constants (k') increased with increasing chlorine dosage. The degradation of GFRZ and BZF was primarily ascribed to reactive chlorine species (RCS) and ozone, while that of CA was mainly attributable to hydroxyl radical (HO) and ozone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193054
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http://dx.doi.org/10.1016/j.chemosphere.2019.03.102DOI Listing
March 2019
4 Reads

Synergic degradation of 2,4,6-trichlorophenol in microbial fuel cells with intimately coupled photocatalytic-electrogenic anode.

Water Res 2019 Jun 12;156:125-135. Epub 2019 Mar 12.

School of Environmental Science & Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, PR China; Hubei Provincial Engineering Laboratory for Solid Waste Treatment Disposal and Recycling, Wuhan, Hubei, 430074, PR China; State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, PR China.

A microbial fuel cell system with intimately coupled photocatalytic-electrogenic anode (photocatalytic-MFC) was proposed for the synergetic degradation of 2,4,6-trichlorophenol (2,4,6-TCP) which has a structure of three chlorine groups connecting to a phenol ring and is well recognized as a recalcitrant pollutant for its high toxicity, bioaccumulation and persistence. The photocatalytic-electrogenic anode was prepared by coating mpg-CN on a carbon felt anode, followed by inoculating with municipal sewage and acclimating with 2,4,6-TCP at gradient concentrations. Improved TCP degradation was achieved, showing 79. Read More

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http://dx.doi.org/10.1016/j.watres.2019.03.001DOI Listing
June 2019
3 Reads

The effect of chlorination degree and substitution pattern on the interactions of polychlorinated biphenyls with model bacterial membranes.

Biochim Biophys Acta Biomembr 2019 Mar 16;1861(6):1057-1068. Epub 2019 Mar 16.

Department of Environmental Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland. Electronic address:

Polychlorinated biphenyls (PCB) are persistent organic pollutants that due to their chemical resistivity and inflammability found multiple applications. In spite of the global ban for PCB production, due to their long half-lives periods, PCB accumulate in the soils, so effective bioremediation of the polluted lands is of crucial importance. Some of the 209 PCB congeners exhibit increased toxicity to soil bacteria and their presence impoverish the soil decomposer community and slows down the degradation of environmental pollutants in the soils. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.03.009DOI Listing
March 2019
1 Read

Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice.

J Agric Food Chem 2019 Apr 20;67(13):3789-3795. Epub 2019 Mar 20.

Department of Nutrition and Food Science , University of Maryland , 0112 Skinner Building , College Park , Maryland 20742 , United States.

A novel synthetic route was designed, developed, and utilized to synthesize six high-purity 2-monochloropropanediol fatty acid esters (2-MCPD esters), a group of potential processing-induced food contaminants. A chlorine atom was introduced to C-2 of a diethyl malonate molecule, which was reduced by NaBH and followed by esterification using fatty acids. The reaction products were isolated and purified using silica gel columns to obtain three 2-MCPD monoesters and three diesters at about 50-54% and 56-59% yields, respectively. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b01083
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http://dx.doi.org/10.1021/acs.jafc.9b01083DOI Listing
April 2019
7 Reads

Shoot chloride translocation as a determinant for NaCl tolerance in Vicia faba L.

J Plant Physiol 2019 Feb 26;236:23-33. Epub 2019 Feb 26.

University of Hohenheim, Institute of Crop Science, 340e, Schloss Westflügel, 70593, Stuttgart, Germany. Electronic address:

Faba bean (Vicia faba L.) is sensitive to salinity. While toxic effects of sodium (Na) are well studied, toxicity aspects of chloride (Cl) and the underlying tolerance mechanisms to Cl are not well understood. Read More

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http://dx.doi.org/10.1016/j.jplph.2019.02.012DOI Listing
February 2019

Facile synthesis and cytotoxicity of phenazine-chromene hybrid molecules derived from phenazine natural product.

Comb Chem High Throughput Screen 2019 Mar 7. Epub 2019 Mar 7.

School of Engineering, China Pharmaceutical University, Nanjing 210009. China.

Aim And Objective: Small molecule targeted drugs can effectively reduce the toxicity and side effects of drugs, and improve the efficacy of drugs by their specific antitumor activity. Hence, the development of small molecular targeted drugs for cancer has important significance. This study was undertaken to design and synthesize novel phenazine-chromene hybrid molecules in order to optimize the structure and improve the efficacy of this kind of hybrids. Read More

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http://dx.doi.org/10.2174/1386207322666190307125015DOI Listing

Effects of chlorination and combined UV/Cl treatment on endotoxin activity and inhalation toxicity of lipopolysaccharide, gram-negative bacteria and reclaimed water.

Water Res 2019 May 22;155:124-130. Epub 2019 Feb 22.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, China. Electronic address:

Disinfection processes were applied in reclaimed water plant to eliminate pathogens and control the related health risk during water reuse. However, extra problems might emerge such as the released free endotoxins from the ruptured cell wall of gram-negative bacteria. Endotoxins can induce lung inflammatory responses after inhalation, which has been neglected in the water quality regulation, and the removal of endotoxin was not under consideration in the process of reclamation. Read More

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http://dx.doi.org/10.1016/j.watres.2019.02.021DOI Listing
May 2019
4 Reads

Tripolyphosphate-assisted electro-Fenton process for coking wastewater treatment at neutral pH.

Environ Sci Pollut Res Int 2019 Mar 1. Epub 2019 Mar 1.

State Key Laboratory of Urban Water Resources Centre, School of Environment, Harbin Institute of Technology, Harbin, 150090, People's Republic of China.

The first application of a novel electro-Fenton (EF) for coking wastewater (CW) treatment at the original pH (6.80) by using tripolyphosphate (TPP) ligand was proposed. Total organic carbon (TOC) decay of CW followed a pseudo-first kinetic rate constant with an apparent rate constant (k) of 1. Read More

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http://dx.doi.org/10.1007/s11356-019-04548-wDOI Listing
March 2019
2 Reads

Comparison of Toxicity-Weighted Disinfection Byproduct Concentrations in Potable Reuse Waters and Conventional Drinking Waters as a New Approach to Assessing the Quality of Advanced Treatment Train Waters.

Environ Sci Technol 2019 Apr 12;53(7):3729-3738. Epub 2019 Mar 12.

Department of Civil and Environmental Engineering , Stanford University , 473 Via Ortega , Stanford , California 94305 , United States.

Advanced treatment trains based on oxidation, biofiltration, and/or granular activated carbon (Ox/BAF/GAC) are an attractive alternative to those based on microfiltration, reverse osmosis, and advanced oxidation (MF/RO/AOP) for the potable reuse of municipal wastewater effluents, but their effluent quality is difficult to validate with respect to chemical contaminants. This study evaluated the sum of the concentrations of 46 disinfection byproducts (DBPs) after treatment by chlorine or chloramines weighted by metrics of toxic potency in 10 full- or pilot-scale reuse trains to estimate the DBP-associated toxicity of their effluents. These total toxicity-weighted DBP concentrations were compared to those measured in their local, conventional drinking waters as a benchmark for water quality receiving regulatory and widespread public acceptance. Read More

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http://dx.doi.org/10.1021/acs.est.8b06711DOI Listing
April 2019
4 Reads

Effect of UV wavelength on humic acid degradation and disinfection by-product formation during the UV/chlorine process.

Water Res 2019 Feb 12;154:199-209. Epub 2019 Feb 12.

State Key Laboratory of Pollution Control and Resource Reuse, Key Laboratory of Yangtze Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China.

The efficiency of the ultraviolet (UV)/chlorine process strongly depends on UV wavelength because chlorine photolysis and its subsequent radical formation are highly wavelength-dependent. This study compared the degradation of humic acid (HA) during the UV/chlorine process by low pressure mercury lamp (LPUV, 254 nm) and ultraviolet light-emitting diode (UV-LED, 275 and 310 nm). The results indicated that HA degradation followed the pseudo-first-order kinetics, and the fluence-based degradation rate constants (k) were significantly affected by UV wavelength and solution pH. Read More

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http://dx.doi.org/10.1016/j.watres.2019.02.004DOI Listing
February 2019

Disinfection by-Products and Ecotoxic Risk Associated with Hypochlorite Treatment of Tramadol.

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Department of Chemical Sciences, University of Napoli Federico II, Via Cintia 4 (ed. 5), I-80126 Naples, Italy.

In recent years, many studies have highlighted the consistent finding of tramadol (TRA) in the effluents from wastewater treatment plants (WTPs) and also in some rivers and lakes in both Europe and North America, suggesting that TRA is removed by no more than 36% by specific disinfection treatments. The extensive use of this drug has led to environmental pollution of both water and soil, up to its detection in growing plants. In order to expand the knowledge about TRA toxicity as well as the nature of its disinfection by-products (DBPs), a simulation of the waste treatment chlorination step has been reported herein. Read More

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http://dx.doi.org/10.3390/molecules24040693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412430PMC
February 2019

Emission characteristics for co-combustion of leather wastes, sewage sludge, and coal in a laboratory-scale entrained flow tube furnace.

Environ Sci Pollut Res Int 2019 Apr 7;26(10):9707-9716. Epub 2019 Feb 7.

State Key Laboratory of Clean Energy Utilization, Institute for Thermal Power Engineering, Zhejiang University, Hangzhou, 310027, China.

Four different mixed fuels consisted of leather waste, coal, and sewage sludge were combusted in a lab-scale entrained flow fluidized bed furnace. The influence of blending ratio on emission characteristics of SO, NO, HCl, particulate matter (PM), heavy metals, and polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) was studied. Results showed that the mixing of coal with sewage sludge had a complex effect on the emission characteristics. Read More

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http://dx.doi.org/10.1007/s11356-019-04347-3DOI Listing
April 2019
3 Reads

Degradation of benzophenone-4 in a UV/chlorine disinfection process: Mechanism and toxicity evaluation.

Chemosphere 2019 May 31;222:494-502. Epub 2019 Jan 31.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, No. 163 Xianlin Avenue, Nanjing 210023, PR China.

This study investigated the degradation of benzophenone-4 (BP-4) in a UV/chlorine disinfection process, with chlorination and UV disinfection as comparisons. With a degradation efficiency of 80% after 10 s, the UV/chlorine process significantly enhanced the degradation of BP-4. However, a rebound of 36% of the initial concentration was observed in the UV/chlorine process ([free active chlorine (FAC)]:[BP-4] = 1:1, pH = 7). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.186DOI Listing
May 2019
4 Reads

Comprehension of heavy metal stability in municipal solid waste incineration fly ash with its compositional variety: A quick prediction case of leaching potential.

Waste Manag 2019 Feb 11;84:329-339. Epub 2018 Dec 11.

School of Environmental and Chemical Engineering, Shanghai University, No. 99 Shangda Road, Baoshan District, Shanghai 200444, PR China.

In the current work, a quick prediction of the heavy metal (HM) leaching potential in municipal solid waste incineration fly ash (MSWI FA) was developed based on the statistical data between the HM leaching behaviors and the compositional variety in FA from China. In the comparison of the surveyed (508 data points) leaching concentrations, Pb and Cd leaching amounts in FA exceeded the Toxicity Characteristic Leaching Procedure (TCLP) limits most frequently. Moreover, the chemical compositions (pH and soluble chlorine (S-Cl)) of FA were proposed to have significant linear correlations with the Pb and Cd leaching. Read More

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http://dx.doi.org/10.1016/j.wasman.2018.11.049DOI Listing
February 2019
2 Reads

The clinical toxicology of sodium hypochlorite.

Clin Toxicol (Phila) 2019 Jan 28:1-9. Epub 2019 Jan 28.

a National Poisons Centre , University of Otago , Dunedin , New Zealand.

Introduction: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach.

Objective: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning.

Methods: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication". Read More

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http://dx.doi.org/10.1080/15563650.2018.1543889DOI Listing
January 2019
3 Reads

Transformation of endocrine disrupting chemicals, pharmaceutical and personal care products during drinking water disinfection.

Sci Total Environ 2019 Mar 11;657:1480-1490. Epub 2018 Dec 11.

Australian Rivers Institute, School of Environment and Science, Griffith University, Southport, Qld 4222, Australia; The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), Woolloongabba, Qld 4102, Australia; UFZ - Helmholtz Centre for Environmental Research, Cell Toxicology, 04318 Leipzig, Germany.

Pharmaceuticals and personal care products (PPCPs) and endocrine disrupting compounds (EDCs) are frequently detected in drinking water sources. This raises concerns about the formation of potentially more toxic transformation products (TPs) after drinking water disinfection. This study applied a combination of computational and experimental methods to investigate the biological activity of eight EDCs and PPCPs commonly detected in source waters (acetaminophen, bisphenol A, carbamazepine, estrone, 17α-ethinylestradiol, gemfibrozil, naproxen and triclosan) before and after disinfection. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.12.106DOI Listing
March 2019
1 Read
4.099 Impact Factor

Pilot-scale comparison of microfiltration/reverse osmosis and ozone/biological activated carbon with UV/hydrogen peroxide or UV/free chlorine AOP treatment for controlling disinfection byproducts during wastewater reuse.

Water Res 2019 Apr 11;152:215-225. Epub 2019 Jan 11.

Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA. Electronic address:

Ozone and biological activated carbon (O/BAC) is being considered as an alternative advanced treatment process to microfiltration and reverse osmosis (MF/RO) for the potable reuse of municipal wastewater. Similarly, the UV/free chlorine (UV/HOCl) advanced oxidation process (AOP) is being considered as an alternative to the UV/hydrogen peroxide (UV/HO) AOP. This study compared the performance of these alternative treatment processes for controlling N-nitrosamines and chloramine-reactive N-nitrosamine and halogenated disinfection byproduct (DBP) precursors during parallel, pilot-scale treatment of tertiary municipal wastewater effluent. Read More

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http://dx.doi.org/10.1016/j.watres.2018.12.062DOI Listing
April 2019
3 Reads

Distribution of polychlorinated biphenyls in effluent from a large municipal wastewater treatment plant: Potential for bioremediation?

J Environ Sci (China) 2019 Apr 21;78:42-52. Epub 2018 Jun 21.

University of Maryland at College Park, Department of Civil and Environmental Engineering, 1147 Glenn L. Martin Hall, College Park, MD 20742, USA. Electronic address:

This study involved an evaluation of the potential for bioremediation of polychlorinated biphenyls (PCBs) in the effluent from a large municipal wastewater treatment plant. It was focused on the presence of PCBs in two types of effluents: the continuous effluent present during dry weather conditions and the intermittently present effluent that was present during wet weather due to incoming stormwater. The annual discharge of PCBs for both types of effluent was calculated based on a five-year dataset (2011-2015). Read More

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http://dx.doi.org/10.1016/j.jes.2018.06.007DOI Listing
April 2019
7 Reads

Impact of chlorine exposure time on disinfection byproduct formation in the presence of iopamidol and natural organic matter during chloramination.

J Environ Sci (China) 2019 Apr 29;78:204-214. Epub 2018 Sep 29.

Department of Civil Engineering, University of Akron, Akron, OH 44325, USA. Electronic address:

Chloramines, in practice, are formed onsite by adding ammonia to chlorinated drinking water to achieve the required disinfection. While regulated disinfection byproducts (DBPs) are reduced during chloramine disinfection, other DBPs such as iodinated (iodo-) DBPs, that elicit greater toxicity are formed. The objective of this study was to investigate the impact of prechlorination time on the formation of both halogen-specific total organic halogen (TOX) and iodo/chlorinated (chloro-) DBPs during prechlorination/chloramination in source waters (SWs) containing iopamidol, an X-ray contrast medium. Read More

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http://dx.doi.org/10.1016/j.jes.2018.09.022DOI Listing
April 2019
3 Reads
2.002 Impact Factor

Empirical Modeling of Zn/ZnO Nanoparticles Decorated/Conjugated with Fotolon (Chlorine e6) Based Photodynamic Therapy towards Liver Cancer Treatment.

Micromachines (Basel) 2019 Jan 17;10(1). Epub 2019 Jan 17.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11543, Saudi Arabia.

The current study is based on Zn/ZnO nanoparticles photodynamic therapy (PDT) mediated effects on healthy liver cells and cancerous cells. The synthesis of Zn/ZnO nanoparticles was accomplished using chemical and hydrothermal methods. The characterization of the synthesized nanoparticles was carried out using manifold techniques (e. Read More

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http://dx.doi.org/10.3390/mi10010060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357181PMC
January 2019
2 Reads

Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study.

Cell Mol Biol Lett 2019 10;24. Epub 2019 Jan 10.

2School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Cancer Hospital of Yunnan Province, Kunming Medical University, NO.1168, West Chunrong Road, Chenggong Developing Area, Kunming, 650031 China.

Objective: To investigate the anti-tumor effects and the mechanism of the compound 13-chlorine-3, 15-dioxy-gibberellic acid methyl ester (GA-13315) in lung adenocarcinoma in vitro and in vivo.

Methods: The antiproliferative effect of GA-13313 on the A549 cell line was determined by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide) assay. A xenograft model of A549 was established to evaluate the anti-tumor effect and histopathological examination was performed to assess the toxicity of GA-13315. Read More

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http://dx.doi.org/10.1186/s11658-018-0126-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327519PMC
April 2019
3 Reads

Toxicological aspects of trihalomethanes: a systematic review.

Environ Sci Pollut Res Int 2019 Feb 3;26(6):5316-5332. Epub 2019 Jan 3.

Development and Environment, Bioscience Center, Federal University of Rio Grande do Norte (UFRN), University Campus, Lagoa Nova, Natal, RN, 59072-970, Brazil.

Chlorine is considered the most used chemical agent for water disinfection worldwide. However, water chlorination can lead to by-product generation which can be toxic to humans. The present study aimed to perform a systematic review on the toxicity of trihalomethanes (THMs) through bioindicators of cytotoxicity, genotoxicity, and mutagenicity. Read More

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http://link.springer.com/10.1007/s11356-018-3949-z
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http://dx.doi.org/10.1007/s11356-018-3949-zDOI Listing
February 2019
11 Reads

Formation of dioxins from triclosan with active chlorine: A potential risk assessment.

J Hazard Mater 2019 Apr 23;367:128-136. Epub 2018 Dec 23.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Electronic address:

Triclosan, a widely used antimicrobial agent, can increase colitis-associated colon tumorigenesis, and induce liver fibrosis and cancer in mice through mechanisms which may be relevant in humans. In this study, an analytical method using gas chromatography-mass spectrometry (GC-MS) and high resolution gas chromatography-high resolution mass spectrometry (HRGC-HRMS) was developed to measure dioxins and chlorinated derivatives from triclosan in the presence of active chlorine in seawater matrix. Formation yields of dioxins and chlorinated triclosans were assessed at different initial precursor concentrations under dark and UV light irradiation conditions. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2018.12.088DOI Listing
April 2019
9 Reads

Degradation of climbazole by UV/chlorine process: Kinetics, transformation pathway and toxicity evaluation.

Chemosphere 2019 Mar 5;219:243-249. Epub 2018 Dec 5.

The Environmental Research Institute, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, 510006, China. Electronic address:

Climbazole is an antifungal agent widely used in household personal care products, and it was found persistent in chlorination disinfection process. Here we investigated the kinetics and mechanism of climbazole degradation by UV/chlorine process. The results showed that the UV/chlorine process dramatically enhanced degradation of climbazole when compared to the UV photolysis and chlorination alone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183234
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http://dx.doi.org/10.1016/j.chemosphere.2018.12.023DOI Listing
March 2019
4 Reads

Transformation of sulfamethazine during the chlorination disinfection process: Transformation, kinetics, and toxicology assessment.

J Environ Sci (China) 2019 Feb 3;76:48-56. Epub 2018 Apr 3.

Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China; Beijing Research Center for Preventive Medicine, Beijing 100013, China. Electronic address:

Various disinfection byproducts (DBPs) form during the process of chlorination disinfection, posing potential threats to drinking water safety and human health. Sulfamethazine (SMT), the most commonly used and frequently detected veterinary antibiotic, was investigated in detail with regard to its transformation and kinetics in reactions with free available chlorine (FAC). Using liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry, several DBPs were identified based on different confidence levels, and a variety of reaction types, including desulfonation, S-N cleavage, hydroxylation, and chlorine substitution, were proposed. Read More

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http://dx.doi.org/10.1016/j.jes.2018.03.024DOI Listing
February 2019
2 Reads

Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation.

Med Chem 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid (PR 445), Km 380, Campus Universitário, Londrina - PR, 86057-970. Brazil.

Background: New drugs and strategies to treat tuberculosis (TB) are urgently needed. In this context, thiourea derivatives have a wide range of biological activities, including anti-TB. This fact can be illustrated with the structure of isoxyl, an old anti-TB drug, which have a thiourea as pharmacophore group. Read More

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http://dx.doi.org/10.2174/1573406415666181208110753DOI Listing
December 2018
8 Reads

Phototransformation of halophenolic disinfection byproducts in receiving seawater: Kinetics, products, and toxicity.

Water Res 2019 Mar 23;150:68-76. Epub 2018 Nov 23.

Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX, USA.

Flushing toilet with seawater is an effective method for preserving freshwater resources, but it introduces iodide and bromide ions into domestic wastewater. During chlorine disinfection, iodide and bromide ions in the saline wastewater effluent lead to the formation of iodinated and brominated aromatic disinfection byproducts (DBPs). Examples of aromatic DBPs include iodophenolic, bromophenolic and chlorophenolic compounds, which generally display substantially higher toxicity than haloaliphatic DBPs. Read More

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http://dx.doi.org/10.1016/j.watres.2018.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390291PMC
March 2019
3 Reads

Sulfadiazine destruction by chlorination in a pilot-scale water distribution system: Kinetics, pathway, and bacterial community structure.

J Hazard Mater 2019 Mar 24;366:88-97. Epub 2018 Nov 24.

School of Civil and Environmental Engineering, Georgia Institute of Technology, USA.

Sulfadiazine (SDZ) has been frequently detected in surface waters in recent years. We evaluated the kinetics, mechanisms, intermediate products and bacterial community structure that result from the reaction of SDZ with free chlorine (HOCl/OCl). We examined this in a pilot-scale water distribution system. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2018.11.096DOI Listing
March 2019
2 Reads

Synthesis and biological evaluation of new quinoline derivatives as antileishmanial and antitrypanosomal agents.

Bioorg Chem 2019 Mar 31;83:526-534. Epub 2018 Oct 31.

Laboratorio de Biocatálisis. Departamento de Química Orgánica y UMYMFOR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, piso 3, C1428EGA Buenos Aires, Argentina. Electronic address:

As a part of our project aimed at developing new safe chemotherapeutic agents against tropical diseases, a series of aryl derivatives of 2- and 3-aminoquinoline, some of them new compounds, was designed, synthesized, and evaluated as antiproliferative agents against Trypanosoma cruzi, the parasite responsible for American trypanosomiasis (Chagas' disease), and Leishmania mexicana, the etiological agent of Leishmaniasis. Some of them showed a remarkable activity as parasite growth inhibitors. Fluorine-containing derivatives 11b and 11c were more than twice more potent than geneticin against intracellular promastigote form of Leishmania mexicana exhibiting both IC values of 41. Read More

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http://dx.doi.org/10.1016/j.bioorg.2018.10.053DOI Listing
March 2019
9 Reads

Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases.

Dalton Trans 2018 Dec;47(47):17032-17045

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.

The anticancer activity of 8-hydroxyquinolines relies on complex formation with redox active copper and iron ions. Here we employ UV-visible spectrophotometry and EPR spectroscopy to compare proton dissociation and complex formation processes of the reference compound 8-hydroxyquinoline (Q-1) and three related Mannich bases to reveal possible correlations with biological activity. The studied derivatives harbor a CH2-N moiety at position 7 linked to morpholine (Q-2), piperidine (Q-3), and chlorine and fluorobenzylamino (Q-4) substituents. Read More

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http://dx.doi.org/10.1039/c8dt03088jDOI Listing
December 2018
8 Reads

Disinfection byproduct formation and toxicity of graphene oxide in water treatment system.

Chemosphere 2019 Feb 1;217:68-75. Epub 2018 Nov 1.

College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, Tong Yan Road 38, Tianjin 300350, China. Electronic address:

Graphene oxide (GO) is a structural analog of graphene and contains numerous O-containing functional groups. As rapidly increasing production and usage of GO, it is inevitable to flow into the water and wastewater treatment system and finally oxidized by disinfectants to form DBPs. Meanwhile, as GO is a nano sized carbon material, it may also break the human digestion system when it was absorbed by human body. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183203
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http://dx.doi.org/10.1016/j.chemosphere.2018.10.165DOI Listing
February 2019
17 Reads
3.340 Impact Factor

Removal of disinfection byproduct precursors and reduction in additive toxicity of chlorinated and chloraminated waters by ozonation and up-flow biological activated carbon process.

Chemosphere 2019 Feb 16;216:624-632. Epub 2018 Oct 16.

Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China.

The variations of disinfection byproduct (DBP) precursors and DBPs-associated toxic potencies were evaluated by ozonation, followed by a up-flow biological activated carbon (O/UBAC) filter treating two reconstituted water samples, featuring either high bromide (105.3 μg/L) or dissolved organic nitrogen (0.73 mg N/L) concentration, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183190
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http://dx.doi.org/10.1016/j.chemosphere.2018.10.052DOI Listing
February 2019
13 Reads
3.340 Impact Factor

Mutagenic Activity of N-Nitrosodiethylamine in Cell Lines Expressing Human CYP2E1-Adequacy of Dimethylsulfoxide as Solvent.

Environ Mol Mutagen 2019 04 29;60(3):214-226. Epub 2018 Nov 29.

Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, People's Republic of China.

Human CYP2E1 metabolizes many xenobiotics of low-molecular weight, thereby activating various promutagens/procarcinogens. In toxicological studies in vitro, dimethylsulfoxide (DMSO) is a common vehicle for organic compounds. However, it was observed to potently inhibit CYP2E1 activity. Read More

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http://doi.wiley.com/10.1002/em.22264
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http://dx.doi.org/10.1002/em.22264DOI Listing
April 2019
13 Reads

Theoretical Investigations on the Reactivity of Hydrogen Peroxide toward 2,3,7,8-Tetrachlorodibenzo--dioxin.

Molecules 2018 Oct 31;23(11). Epub 2018 Oct 31.

Key Laboratory of Life-Organic Analysis, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

Acquiring full knowledge of the reactivity of 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) is crucial for the better understanding of the transformation and degradation of TCDD-like dioxins in the environment. To clarify the reactivity of the organic hydroperoxides toward TCDD, in this study, the reactions between the neutral/anion of the hydrogen peroxide (H₂O₂) and TCDD have been systematically investigated theoretically. It was found that the neutral H₂O₂ is relatively difficult to react with TCDD compared with its anion, exhibiting the pH dependence of the title reaction. Read More

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http://www.mdpi.com/1420-3049/23/11/2826
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http://dx.doi.org/10.3390/molecules23112826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278397PMC
October 2018
3 Reads

Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls.

Regul Toxicol Pharmacol 2019 Feb 22;101:12-23. Epub 2018 Oct 22.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address:

The application of toxic equivalency factors (TEFs) or toxic units to estimate toxic potencies for mixtures of chemicals which contribute to a biological effect through a common mechanism is one approach for filling data gaps. Toxic Equivalents (TEQ) have been used to express the toxicity of dioxin-like compounds (i.e. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.10.013DOI Listing
February 2019
3 Reads

User and environment friendly direct agglutination test for the sero-diagnosis of visceral leishmaniasis: exclusion of formaldehyde and β-mercaptoethanol in test execution.

J Med Microbiol 2018 Dec 16;67(12):1731-1736. Epub 2018 Oct 16.

1​Laboratory of Biomedical Research, Ahfad University for Women, P.O. Box 167, Omdurman, Sudan.

Purpose: Based on world-wide evaluation, the direct agglutination test (DAT) is now generally acknowledged as one of the leading diagnostics for visceral leishmaniasis (VL). To enhance more routine and mass application, but simultaneously ensure safety to both user and environment, further improvements need to be introduced.

Methodology: In the current format, a two-sixfold titre decrease was observed due to using formaldehyde as an antigen preservative in DAT. Read More

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http://dx.doi.org/10.1099/jmm.0.000858DOI Listing
December 2018
3 Reads

Formation of iodinated trihalomethanes and haloacetic acids from aromatic iodinated disinfection byproducts during chloramination.

Water Res 2018 12 2;147:254-263. Epub 2018 Oct 2.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China.

Iodinated disinfection byproducts (DBPs) are widely present in disinfected drinking waters and wastewater effluents, and they have drawn increasing concern owing to their high toxicity. To date, the reported iodinated DBPs mainly include aliphatic and aromatic ones, and iodinated trihalomethanes (THMs) and haloacetic acids (HAAs) are the most commonly detected aliphatic iodinated DBPs in disinfected waters. In this study, the formation of iodinated THMs and HAAs from aromatic iodinated DBPs during chloramination was investigated. Read More

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http://dx.doi.org/10.1016/j.watres.2018.09.058DOI Listing
December 2018
8 Reads

Improved DBP elimination from swimming pool water by continuous combined UV and ozone treatment.

Water Res 2018 12 29;147:214-222. Epub 2018 Sep 29.

Department of Environmental Engineering, Technical University of Denmark, 2800, Lyngby, Denmark.

Chlorine is the most frequently used disinfectant and oxidant for maintaining swimming pool water quality; however, it reacts continuously with dissolved organic matter to produce disinfection by-products (DBPs), which are a health risk for pool users. UV treatment is used widely to remove chloramines, which are the most prevalent group of DBPs, albeit chloro-organic DBP concentrations often increase during post-UV chlorination. In this work, UV and ozone treatments were investigated as additional technologies to eliminate DBP formation and their precursors. Read More

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http://dx.doi.org/10.1016/j.watres.2018.09.030DOI Listing
December 2018
7 Reads

Elimination kinetics and detoxification mechanisms of microcystin-LR during UV/Chlorine process.

Chemosphere 2019 Jan 29;214:702-709. Epub 2018 Sep 29.

School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

Microcystin-LR (MC-LR), a toxin produced by cyanobacteria, is very toxic and poses a threat to public health when entering water treatment works. In this study, UV/chlorine process, as an advanced oxidation process (AOP), has been demonstrated for effective elimination of MC-LR levels and associated toxicity. At a chlorine dose of 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183182
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http://dx.doi.org/10.1016/j.chemosphere.2018.09.162DOI Listing
January 2019
21 Reads

The downside of antimicrobial agents for wound healing.

Eur J Clin Microbiol Infect Dis 2019 Jan 5;38(1):39-54. Epub 2018 Oct 5.

Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

The use of topical antimicrobials is beneficial for infection control in wound care because wound infection is the major cause of delayed healing. The advantages of topical over systemic antimicrobials include a higher concentration at the target site, fewer systemic adverse effects, and a lower incidence of antimicrobial resistance. Nowadays, topical antimicrobials are divided into three groups: disinfectants, antiseptics, and antibiotics. Read More

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http://dx.doi.org/10.1007/s10096-018-3393-5DOI Listing
January 2019
22 Reads

Degradation of sulfonamides and formation of trihalomethanes by chlorination after pre-oxidation with Fe(VI).

J Environ Sci (China) 2018 Nov 2;73:89-95. Epub 2018 Feb 2.

College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310027, China. Electronic address:

Sulfonamides are used in human therapy, animal husbandry and agriculture but are not easily biodegradable, and are often detected in surface water. Sulfamethazine (SMZ) and sulfadiazine (SDZ) are two widely used sulfonamide antibiotics that are used heavily in agriculture. In this study, they were degraded in an aqueous system by chlorination after pre-oxidation with ferrate(VI) (FeO, Fe(VI)), an environmentally friendly oxidation technique that has been shown to be effective in degrading various organics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10010742173320
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http://dx.doi.org/10.1016/j.jes.2018.01.016DOI Listing
November 2018
5 Reads

Photodynamic therapy using ultradeformable liposomes loaded with chlorine aluminum phthalocyanine against L. (V.) braziliensis experimental models.

Exp Parasitol 2018 Nov 23;194:45-52. Epub 2018 Sep 23.

Centro de Investigación en Enfermedades Tropicales (CINTROP-UIS), Departamento de Ciencias Básicas, Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia.

Ultradeformable liposomes (UDLs) containing sodium cholate as edge activator could be an appropriate skin drug-delivery system for chloroaluminum phthalocyanine (ClAlPc) during photodynamic therapy (PDT) against cutaneous leishmaniasis (CL). The aim of this work was to study cell internalization, reactive oxygen species (ROS) production, and toxicity/genotoxicity and transdermal delivery of UDL-ClAlPc, and to determine whether PDT was able to induce anti-leishmanial activity in Leishmania (Viannia) braziliensis experimental models. Prepared liposomes had an average size of 118. Read More

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http://dx.doi.org/10.1016/j.exppara.2018.09.016DOI Listing
November 2018
7 Reads

Formation of disinfection byproducts from sulfamethoxazole during sodium hypochlorite disinfection of marine culture water.

Environ Sci Pollut Res Int 2018 Nov 25;25(33):33196-33206. Epub 2018 Sep 25.

School of Marine Sciences, Guangxi University, Nanning, 530004, China.

The fates of the antibiotic sulfamethoxazole (SMX) in the chlorination of fresh water, simulated brackish marine culture water, and marine water were investigated. SMX was oxidized by sodium hypochlorite (NaClO) at different reaction rates in the different samples. The oxidation of SMX followed pseudo-first-order kinetics, and the rate constant was the largest in marine water (3. Read More

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http://link.springer.com/10.1007/s11356-018-3278-2
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http://dx.doi.org/10.1007/s11356-018-3278-2DOI Listing
November 2018
4 Reads

Identification of a mutagenic chlorination by-product produced from (E)-1, 3-dichloropropene (a component of nematocide DD) by using high resolution LC/MS and multivariate analysis.

Water Res 2018 12 14;146:187-196. Epub 2018 Sep 14.

Division of Natural Environment and Information, Faculty of Environment and Information Sciences, Yokohama National University, Yokohama, 240-8501, Japan. Electronic address:

The estimated domestic usage of DD (a typical nematocide) has been the greatest among all the agricultural chemicals in Japan. DD is involved in a document which is used to establish tap water quality standard in Japan. The document indicates that DD is potentially detectable in raw water for tap waters. Read More

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http://dx.doi.org/10.1016/j.watres.2018.09.024DOI Listing
December 2018
7 Reads

Fast degradation of diclofenac by catalytic hydrodechlorination.

Chemosphere 2018 Dec 7;213:141-148. Epub 2018 Sep 7.

Seccion Departamental Ingenieria Quimica, Universidad Autonoma de Madrid, Ctra. Colmenar km 15, 28049 Madrid, Spain.

Aqueous-phase catalytic hydrodechlorination (HDC) has been scarcely explored in the literature for the removal of chlorinated micropollutants. The aim of this work is to prove the feasibility of this technology for the fast and environmentally-friendly degradation of such kind of compounds. Diclofenac (DCF), a highly consumed anti-inflammatory drug, has been selected as the target pollutant given its toxicity and low biodegradability. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.09.024DOI Listing
December 2018
3 Reads

Disinfection by-products formation and ecotoxicological effects of effluents treated with peracetic acid: A review.

Chemosphere 2018 Dec 3;213:25-40. Epub 2018 Sep 3.

Politecnico di Milano, Department of Civil and Environmental Engineering (DICA) - Environmental Section, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. Electronic address:

Peracetic acid (PAA) has gained increasing attention over the last decades as a suitable and environmentally-friendly alternative to chlorine-based compounds for wastewater disinfection, claiming limited disinfection by-products (DBPs) formed and no persistent residues in the environment. The present work aims at presenting a comprehensive and updated review of the ecotoxicological effects of effluents treated with PAA, to be ascribed to residual PAA and hydrogen peroxide (HO) and DBP formation. Modest concentrations of DBPs have been observed after PAA treatment, mainly carboxylic acids, which are not recognized as genotoxic. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.09.005DOI Listing
December 2018
4 Reads

[Exposure to disinfection by-products during gestation and newborns' small for gestational age].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Sep;52(9):885-891

Department of Occupational and Environmental Health and Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To explore the associations between exposure to chlorination disinfection by-products (CDBPs) during gestation and newborns' small for gestational age (SGA). During April 2010 to July 2012, a total of 3 903 pregnant women who lived in a district with the same water treatment plant in Wuhan, China were recruited to this perspective study. Information about demographic characteristics of pregnant women and their newborns was collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.09.004DOI Listing
September 2018
18 Reads