2,413 results match your criteria Toxicity Carbon Monoxide


The interrelationship between gasotransmitters and lead-induced renal toxicity in rats.

Toxicol Lett 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.

This study explored the role of gasotransmitters in lead-induced nephrotoxicity. Long-term exposure of rats to lead resulted in its accumulation in kidney. The accumulated metal impaired kidney function and structure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274193009
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http://dx.doi.org/10.1016/j.toxlet.2019.04.012DOI Listing
April 2019
2 Reads

User-oriented independent analysis of the toxic load model's ability to predict the effects of time-varying toxic inhalation exposures.

Regul Toxicol Pharmacol 2019 Apr 9. Epub 2019 Apr 9.

Institute for Defense Analyses, 4850 Mark Center Drive, Alexandria, VA, 22311-1882, USA.

Toxic industrial chemicals and chemical warfare agents present an acute inhalation hazard to exposed populations. The hazardous materials consequence assessment modeling community requires toxicity models to estimate these hazards. One popular phenomenological toxicity model is the toxic load model. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.04.003DOI Listing

Concurrent Paclitaxel and Radiotherapy for Node Positive Breast Cancer.

Gulf J Oncolog 2019 Jan;1(29):14-21

Clinical Oncology Department (NEMROCK), Kasr Al-Ainy School of Medicine, Cairo University, Egypt.

Background: Concurrent chemo-radiotherapy in breast cancer (BC) may yield better local control with minimal toxicity in node positive patients. The feasibility of paclitaxel with radiotherapy was assessed for tolerability, cosmetic outcome as well as local control.

Methods: A prospective feasibility study on forty-three female breast cancer with stage II-III was conducted after definite surgery (modified radical mastectomy and breast conservative surgery). Read More

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January 2019
3 Reads

A case of delayed neurological manifestation following carbon monoxide poisoning in Sri Lanka: epidemiology of exposure and literature review.

BMC Pharmacol Toxicol 2019 Apr 5;20(1):17. Epub 2019 Apr 5.

Associate Professor, Department of Pathology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Carbon monoxide poisoning is a common emergency worldwide, which carries high morbidity and mortality. Some patients who recover from the insult of acute carbon monoxide toxicity may later develop delayed neuropsychiatric sequelae (DNS) after a lucid period in the form of cognitive impairments, a broad spectrum of neurological deficits and affective disorders. Here, we present the first case of DNS following carbon monoxide poisoning in Sri Lanka and epidemiology of the exposure of nine (9) more victims. Read More

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http://dx.doi.org/10.1186/s40360-019-0295-9DOI Listing
April 2019
1 Read

Ambient carbon monoxide and increased risk of daily hospital outpatient visits for respiratory diseases in Dongguan, China.

Sci Total Environ 2019 Jun 22;668:254-260. Epub 2019 Feb 22.

School of Public Health, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. Electronic address:

Background: The toxicity of high-concentration carbon monoxide (CO) on human health has previously been documented. However, the epidemiological evidence on the association between acute exposure to ambient CO and respiratory diseases is relatively lacking and controversial.

Objectives: To examine the short-term association between ambient CO and hospital outpatient visits for respiratory diseases in Dongguan, China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.333DOI Listing
June 2019
2 Reads
4.099 Impact Factor

Biogeochemical behavior of nickel under different abiotic stresses: toxicity and detoxification mechanisms in plants.

Environ Sci Pollut Res Int 2019 Apr 5;26(11):10496-10514. Epub 2019 Mar 5.

Institute of Soil and Environmental Sciences, University of Agriculture Faisalabad, Faisalabad, 38040, Pakistan.

Nickel (Ni) is a ubiquitous and highly important heavy metal. At low levels, Ni plays an essential role in plants such as its role in urease, superoxide dismutase, methyl-coenzyme M reductase, hydrogenase, acetyl-coenzyme A synthase, and carbon monoxide dehydrogenase enzyme. Although its deficiency in crops is very uncommon, but in the past few years, many studies have demonstrated Ni deficiency symptoms in plants. Read More

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http://dx.doi.org/10.1007/s11356-019-04540-4DOI Listing
April 2019
6 Reads
2.828 Impact Factor

Pulmonary function abnormalities are common in patients with multiple myeloma and are independently associated with worse outcome.

Ann Hematol 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 80 Vasilissis Sofias, 11258, Athens, Greece.

Pre-existing pulmonary disease may affect treatment choices, toxicity, and survival of patients with multiple myeloma (MM). However, data on the prognostic value of pulmonary function tests (PFTs) in myeloma patients' outcome, at the time of initial assessment of newly diagnosed patients, are scarce. Here, we prospectively performed PFTs in 121 newly diagnosed MM patients, before initiation of treatment, and we evaluated possible associations of lung function with their outcomes. Read More

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http://dx.doi.org/10.1007/s00277-019-03641-xDOI Listing
March 2019
10 Reads

A retrospective study of poisoning deaths from forensic autopsy cases in northeast China (Liaoning).

J Forensic Leg Med 2019 Apr 21;63:7-10. Epub 2019 Feb 21.

School of Forensic Medicine, China Medical University, Shenyang 110122, China. Electronic address:

Acute poisoning is a public health threat that leads to morbidity and mortality worldwide. In this retrospective study, we evaluated autopsies from deaths caused by acute poisoning from 2008 to 2017 at the School of Forensic Medicine, China Medical University (SFMCMU) in the Liaoning Province, northeast China. A total of 140 poisoning deaths were investigated and the demographic characteristics, causes and manner of death, toxics category were analyzed. Read More

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http://dx.doi.org/10.1016/j.jflm.2019.02.008DOI Listing
April 2019
3 Reads
0.989 Impact Factor

Determination of carboxyhemoglobin half-life in patients with carbon monoxide toxicity treated with high flow nasal cannula oxygen therapy.

Clin Toxicol (Phila) 2019 Jan 28:1-7. Epub 2019 Jan 28.

b Department of Emergency Medicine , Faculty of Medicine, Kocaeli University , Kocaeli , Turkey.

Background: Acute carbon monoxide poisoning is a common environmental emergency worldwide. Treatment options are limited to normobaric oxygen therapy with a nonrebreather face mask or endotracheal tube and hyperbaric oxygen. The aim of this study is to determine the half-life of carboxyhemoglobin (COHb) in adult patients admitted to the emergency department with acute carbon monoxide poisoning receiving high flow nasal cannula (HFNC) oxygen. Read More

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http://dx.doi.org/10.1080/15563650.2018.1540046DOI Listing
January 2019
2 Reads

Exposure to Secondhand Smoke and Arrhythmogenic Cardiac Alternans in a Mouse Model.

Environ Health Perspect 2018 12;126(12):127001

Department of Pharmacology, University of California, Davis, Davis, California, USA.

Background: Epidemiological evidence suggests that a majority of deaths attributed to secondhand smoke (SHS) exposure are cardiovascular related. However, to our knowledge, the impact of SHS on cardiac electrophysiology, [Formula: see text] handling, and arrhythmia risk has not been studied.

Objectives: The purpose of this study was to investigate the impact of an environmentally relevant concentration of SHS on cardiac electrophysiology and indicators of arrhythmia. Read More

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http://dx.doi.org/10.1289/EHP3664DOI Listing
December 2018
22 Reads
7.977 Impact Factor

The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity.

Part Fibre Toxicol 2019 01 8;16(1). Epub 2019 Jan 8.

Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment & Health, School of Population Health and Environmental Sciences, Franklin-Wilkins Building, King's College London, London, SE1 9NH, UK.

Background: Combustion of biodiesels in place of fossil diesel (FD) has been proposed as a method of reducing transport-related toxic emissions in Europe. While biodiesel exhaust (BDE) contains fewer hydrocarbons, total particulates and carbon monoxide than FD exhaust (FDE), its high nitrogen oxide and ultrafine particle content may still promote pulmonary pathophysiologies.

Main Body: Using a complement of in vitro and in vivo studies, this review documents progress in our understanding of pulmonary responses to BDE exposure. Read More

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http://dx.doi.org/10.1186/s12989-018-0284-yDOI Listing
January 2019
6 Reads

The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy.

Med Chem 2018 Dec 18. Epub 2018 Dec 18.

Department of Respiratory Medicine, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021. China.

Hyperbaric Oxygenation Therapy (HBOT) is used as adjunctive method for multiple diseases. The method meets the routine treating and is non-invasive, as well as provides 100% pure oxygen (O2) which is at above-normal atmospheric pressure in a specialized chamber. It is well known that in the condition of O2 deficiency, it will induce a series of adverse events. Read More

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http://dx.doi.org/10.2174/1573406415666181219101328DOI Listing
December 2018
3 Reads

Understanding the effect of indoor air pollution on pneumonia in children under 5 in low- and middle-income countries: a systematic review of evidence.

Environ Sci Pollut Res Int 2019 Feb 19;26(4):3208-3225. Epub 2018 Dec 19.

Division of Epidemiology and Public Health, University of Nottingham, Nottingham City Hospital, Clinical Sciences Building, Hucknall Road, Nottingham, NG5 1PB, UK.

Exposure to indoor air pollution increases the risk of pneumonia in children, accounting for about a million deaths globally. This study investigates the individual effect of solid fuel, carbon monoxide (CO), black carbon (BC) and particulate matter (PM) on pneumonia in children under 5 in low- and middle-income countries. A systematic review was conducted to identify peer-reviewed and grey full-text documents without restrictions to study design, language or year of publication using nine databases (Embase, PubMed, EBSCO/CINAHL, Scopus, Web of Knowledge, WHO Library Database (WHOLIS), Integrated Regional Information Networks (IRIN), the World Meteorological Organization (WMO)-WHO and Intergovernmental Panel on Climate Change (IPCC). Read More

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http://dx.doi.org/10.1007/s11356-018-3769-1DOI Listing
February 2019
5 Reads

Short-term Effect of Ambient Air Pollution on Emergency Department Visits for Diabetic Coma in Seoul, Korea.

J Prev Med Public Health 2018 Nov 29;51(6):265-274. Epub 2018 Oct 29.

Institute of Human Complexity and Systems Science, Yonsei University, Incheon, Korea.

Objectives: A positive association between air pollution and both the incidence and prevalence of diabetes mellitus (DM) has been reported in some epidemiologic and animal studies, but little research has evaluated the relationship between air pollution and diabetic coma. Diabetic coma is an acute complication of DM caused by diabetic ketoacidosis or hyperosmolar hyperglycemic state, which is characterized by extreme hyperglycemia accompanied by coma. We conducted a time-series study with a generalized additive model using a distributed-lag non-linear model to assess the association between ambient air pollution (particulate matter less than 10 μm in aerodynamic diameter, nitrogen dioxide [NO2], sulfur dioxide, carbon monoxide, and ozone) and emergency department (ED) visits for DM with coma in Seoul, Korea from 2005 to 2009. Read More

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http://dx.doi.org/10.3961/jpmph.18.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283743PMC
November 2018
3 Reads

Lung function changes after chemoradiation therapy in patients with lung cancer treated by three usual platinum combinations.

J Thorac Dis 2018 Sep;10(9):5435-5442

Departments of Respiratory Medicine, Medical School Democritus University of Thrace, Alexandroupolis, Greece.

Background: Reports point out lung toxicity of chemotherapeutic agents and radiation therapy in cancer patients. The aim of our study was to assess lung function after sequential chemoradiation therapy in patients with lung cancer.

Methods: Fifteen lung cancer patients participated the study and underwent lung function assessment before and after sequential treatment of chemotherapy with the 3 most applied platinum-based combinations: of vinorelbine (VN) 6 patients, gemcitabine (GEM) 4 patients and etoposide (EP) 5 patients and radiation therapy. Read More

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http://jtd.amegroups.com/article/view/23954/18345
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http://dx.doi.org/10.21037/jtd.2018.08.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196207PMC
September 2018
22 Reads

Carbon monoxide attenuates amyloidogenesis via down-regulation of NF-κB-mediated BACE1 gene expression.

Aging Cell 2019 Feb 9;18(1):e12864. Epub 2018 Nov 9.

Meta-Inflammation Research Institute of Basic Research, School of Biological Sciences, University of Ulsan, Ulsan, South Korea.

Amyloid-β (Aβ) peptides, the major constituent of plaques, are generated by sequential proteolytic cleavage of the amyloid precursor protein (APP) via β-secretase (BACE1) and the γ-secretase complex. It has been proposed that the abnormal secretion and accumulation of Aβ are the initial causative events in the development of Alzheimer's disease (AD). Drugs modulating this pathway could be used for AD treatment. Read More

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http://doi.wiley.com/10.1111/acel.12864
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http://dx.doi.org/10.1111/acel.12864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351829PMC
February 2019
10 Reads

Exhaled carbon monoxide levels correlate with incidence of oral mucosal lesions independent of smoking status.

Int J Environ Health Res 2019 Jun 30;29(3):290-300. Epub 2018 Oct 30.

b Department of Angiology , Jagiellonian University Medical College , Krakow , Poland.

Carbon monoxide (CO) is an important component of tobacco smoke, but also environmental toxicity. This study analyzed possible correlation between exhaled CO level and oral health indicators in two geographically distributed populations during health-promoting public events organized for local communities in cities with high and low environmental pollution in Poland (907 patients). Self-reported, instructor-led, oral health questionnaire was developed to monitor current and previous mucosal lesion incidence. Read More

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http://dx.doi.org/10.1080/09603123.2018.1541442DOI Listing
June 2019
3 Reads

Carbon monoxide inhibits the anticoagulant activity of phospholipase A purified from Crotalus adamanteus venom.

Authors:
Vance G Nielsen

J Thromb Thrombolysis 2019 Jan;47(1):73-79

Department of Anesthesiology, The University of Arizona College of Medicine, 1501 North Campbell Avenue, P.O. Box 245114, Tucson, AZ, 85724-5114, USA.

Snake venom contains a myriad of classes of enzyme which have been investigated for medicinal and toxinological purposes, including phospholipase A (PLA), which is responsible for anticoagulant, myotoxic and neurotoxic effects. Given the importance of PLA, the purposes of the present investigation were to characterize the coagulation kinetic behavior of a PLA purified from Crotalus adamanteus venom (Ca-PLA) in human plasma with thrombelastography and determine if carbon monoxide could inhibit its activity. Coagulation kinetics were determined in human plasma with a range of Ca-PLA activity (0-2 U/ml) via thrombelastography. Read More

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http://dx.doi.org/10.1007/s11239-018-1763-6DOI Listing
January 2019
1 Read

Total Blood Carbon Monoxide: Alternative to Carboxyhemoglobin as Biological Marker for Carbon Monoxide Poisoning Determination.

Authors:
S Oliverio V Varlet

J Anal Toxicol 2018 Oct 29. Epub 2018 Oct 29.

Forensic Toxicology and Chemistry Unit, University Centre of Legal Medicine Lausanne-Geneva, Chemin de la Vulliette 4, Lausanne, Switzerland.

As one of the most abundant toxic contaminants in the atmosphere, carbon monoxide (CO) plays a significant role in toxicology and public health. Every year, around half of the accidental non-fire-related poisoning deaths are attributed to CO in the USA, UK and many other countries. However, due to the non-specificity of the symptoms and often encountered inconsistency of these with the results obtained from measurements of the biomarker for CO poisonings, carboxyhemoglobin (COHb), there is a high rate of misdiagnoses. Read More

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https://academic.oup.com/jat/advance-article/doi/10.1093/jat
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http://dx.doi.org/10.1093/jat/bky084DOI Listing
October 2018
7 Reads

Biocides Used as Additives to Biodiesels and Their Risks to the Environment and Public Health: A Review.

Molecules 2018 Oct 19;23(10). Epub 2018 Oct 19.

Postgraduate Program in Biomedical Engineering, Campus Gama (FGA), University of Brasília (UnB), Brasília 72.444-240, Brazil.

One of the advantages of using biodiesel and its blends with diesel oil is the lower levels of emissions of particulate matter, sulfur dioxide, carbon monoxide, among others, making it less harmful to the environment and to humans. However, this biofuel is susceptible to microbial contamination and biodeterioration. In this sense, studies on the use of effective low toxicity biocides are being carried out, and this work aims to present the latest information (2008⁻2018) available in the scientific databases, on the use of biocides in biodiesel, mainly concerning their toxicity to the environment and public health. Read More

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http://dx.doi.org/10.3390/molecules23102698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222844PMC
October 2018
3 Reads

Increasing risk of congenital anomalies associated with seasonal pattern of air pollution: Differences by maternal comorbidities.

Ecotoxicol Environ Saf 2019 Jan 18;167:317-323. Epub 2018 Oct 18.

Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau & Inner Mongolia Key Laboratory of Grassland Ecology, School of Ecology and Environment, Inner Mongolia University, Hohhot 010021, China; Institute of Environmental Geology, Inner Mongolia University, Hohhot 010021, China. Electronic address:

To interpret the relationship of the seasonal pattern of air pollution exposure associated with increased risk of congenital anomalies (CA) and the trimester-specific effects. In this work, 55,428 hospital records with 847 doctor-diagnosed CA from July 2013 to December 2016 were collected in Hohhot, China. Maternal exposure to critical air pollutants (SO, CO, PM, O, NO and PM) were estimated using an inverse distance weighted (IDW) method on the basis of the ambient air quality monitoring stations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183104
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http://dx.doi.org/10.1016/j.ecoenv.2018.10.037DOI Listing
January 2019
7 Reads

Synthesis, toxicities and bio-activities of manganese complexes with CO and HS dual donors.

Eur J Med Chem 2018 Nov 4;159:339-356. Epub 2018 Oct 4.

School of Stomatology of Lanzhou University; Lanzhou, 730000, China.

A series of HSCO dual-donors [Mn(CO)CSNRR] was synthesized, and evaluated from toxicity and bioactivity. The COHS measuring test showed all the complexes not only released CO, but released HS. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A-A had almost no activities against all five tumor cell lines and W138 cell line proliferation. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.10.004DOI Listing
November 2018
4 Reads
3.450 Impact Factor

Sodium nitrite food poisoning in one family.

Forensic Sci Med Pathol 2019 03 6;15(1):102-105. Epub 2018 Oct 6.

Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str, Belgrade, 11000, Serbia.

Sodium nitrite is used as a coloring agent or preservative in food, as well as an antimicrobial agent in meat and fish and some cheeses. In high amounts it can be toxic for humans, causing methemoglobinemia. This is an unusual and potentially fatal condition in which hemoglobin is oxidized to methemoglobin (MHb), reducing the amount of oxygen that is released from hemoglobin, similar to carbon monoxide poisoning. Read More

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http://link.springer.com/10.1007/s12024-018-0036-1
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http://dx.doi.org/10.1007/s12024-018-0036-1DOI Listing
March 2019
10 Reads

Association between ambient air pollution and daily hospital admissions for ischemic stroke: A nationwide time-series analysis.

PLoS Med 2018 10 4;15(10):e1002668. Epub 2018 Oct 4.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: Evidence of the short-term effects of ambient air pollution on the risk of ischemic stroke in low- and middle-income countries is limited and inconsistent. We aimed to examine the associations between air pollution and daily hospital admissions for ischemic stroke in China.

Methods And Findings: We identified hospital admissions for ischemic stroke in 2014-2016 from the national database covering up to 0. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171821PMC
October 2018
4 Reads

Association of fine particulate matter on acute exacerbation of chronic obstructive pulmonary disease in Yancheng, China.

Sci Total Environ 2019 Feb 22;650(Pt 2):1665-1670. Epub 2018 Sep 22.

Department of Respiratory Medicine, the First People's Hospital of Yancheng, the Fourth Affiliated Hospital of Nantong University, Jiangsu Province 224006, China. Electronic address:

Background: Epidemiological evidence on the association between short-term exposure to fine particulate matter (PM) air pollution and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is limited in China.

Objectives: To explore the associations between PM and AECOPD in Yancheng, China from 2015 to 2017.

Methods: In this time-series study, we used a generalized linear model with quasi-Poisson regression to investigate the association between PM and AECOPD admitted in two major hospitals in Yancheng. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.278DOI Listing
February 2019
12 Reads

Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods.

PLoS One 2018 27;13(9):e0204624. Epub 2018 Sep 27.

ITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.

Therapy with inhaled carbon monoxide (CO) is being tested in human clinical trials, yet the alternative use of prodrugs, CO-Releasing Molecules (CORMs), is conceptually advantageous. These molecules are designed to release carbon monoxide in specific tissues, in response to some locally expressed stimulus, where CO can trigger a cytoprotective response. The design of such prodrugs, mostly metal carbonyl complexes, must consider their ADMET profiles, including their interaction with transport plasma proteins. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204624PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160121PMC
March 2019
2 Reads

Mechanisms of toxic cardiomyopathy.

Authors:
Philippe Hantson

Clin Toxicol (Phila) 2019 Jan 27;57(1):1-9. Epub 2018 Sep 27.

a Department of Intensive Care , Cliniques St-Luc, Université catholique de Louvain , Brussels , Belgium.

Background: Dilated cardiomyopathy is a frequent disease responsible for 40-50% of cases of heart failure. Idiopathic cardiomyopathy is a primary disorder often related to familial/genetic predisposition. Before the diagnosis of idiopathic cardiomyopathy is made, clinicians must not only rule out viral and immune causes, but also toxic causes such as drugs, environmental agents, illicit substances and natural toxins. Read More

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http://dx.doi.org/10.1080/15563650.2018.1497172DOI Listing
January 2019
17 Reads

The porcine odorant-binding protein as molecular probe for benzene detection.

PLoS One 2018 5;13(9):e0202630. Epub 2018 Sep 5.

Institute of Food Science, Consiglio Nazionale delle Ricerche, Avellino, Italy.

In recent years, air pollution has been a subject of great scientific and public interests for the strong impact on human health. Air pollution is due to the presence in the atmosphere of polluting substances, such as carbon monoxide, sulfur and nitrogen oxides, particulates and volatile organic compounds (VOCs), derived predominantly from various combustion processes. Benzene is a VOC belonging to group-I carcinogens with a toxicity widely demonstrated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124761PMC
February 2019
11 Reads

Hydrogen sulphide trapeze: Environmental stress amelioration and phytohormone crosstalk.

Plant Physiol Biochem 2018 Nov 24;132:46-53. Epub 2018 Aug 24.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, 700016, West Bengal, India. Electronic address:

Hydrogen sulphide (HS) is recognized as the third endogenous gasotransmitter in plants after nitric oxide (NO) and carbon monoxide (CO). Though initially visualized as a toxic gaseous molecule, recent studies have illustrated its diverse role in regulating plant growth and developmental physiology. HS is also a potent inducer of osmolytes and cellular antioxidants of enzymatic and non-enzymatic origins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09819428183038
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http://dx.doi.org/10.1016/j.plaphy.2018.08.028DOI Listing
November 2018
20 Reads

Differences in puff topography, toxicant exposure, and subjective response between waterpipe tobacco smoking men and women.

Exp Clin Psychopharmacol 2018 Oct 13;26(5):440-447. Epub 2018 Aug 13.

Department of Psychology.

Waterpipe tobacco smoking (WTS) exposes users to toxicants in much greater amounts than a cigarette. Little is known about how gender affects WTS toxicant exposure and subjective response. Data from three WTS clinical laboratory studies were combined for analysis. Read More

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http://dx.doi.org/10.1037/pha0000207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162145PMC
October 2018
4 Reads

Role of heme modulation in inhibition of Atheris, Atractaspis, Causus, Cerastes, Echis, and Macrovipera hemotoxic venom activity.

Authors:
V G Nielsen N Frank

Hum Exp Toxicol 2019 Feb 8;38(2):216-226. Epub 2018 Aug 8.

2 Mtoxins, Oshkosh, WI, USA.

Venomous snake bite and subsequent coagulopathy is a significant source of morbidity and mortality worldwide. The gold standard to treat coagulopathy caused by these venoms is the administration of antivenom; however, despite this therapy, coagulopathy still occurs and recurs. Of interest, our laboratory has demonstrated in vitro and in vivo that coagulopathy-inducing venom exposed to carbon monoxide (CO) is inhibited, potentially by an attached heme. Read More

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http://dx.doi.org/10.1177/0960327118793186DOI Listing
February 2019
2 Reads

Combustion Behaviors of CIGS Thin-Film Solar Modules from Cone Calorimeter Tests.

Materials (Basel) 2018 Aug 4;11(8). Epub 2018 Aug 4.

State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, China.

As is well known, building integrated photovoltaic (BIPV) technology is becoming more commonly used in residential and commercial buildings. Fire assessment of photovoltaic (PV) modules as a whole is still insufficient. This work focuses on the thermal properties and combustion behavior of CIGS (copper, indium, gallium and selenium) thin-film modules. Read More

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http://dx.doi.org/10.3390/ma11081353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119912PMC
August 2018
3 Reads

Regulatory role of heme oxygenase-1 in silica-induced lung injury.

Respir Res 2018 08 1;19(1):144. Epub 2018 Aug 1.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.

Background: Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluation methods such as chest X-ray, computed tomography, and spirometry, we identified heme oxygenase (HO)-1, an inducible antioxidant, as a potential biomarker to identify at-risk patients. We found that HO-1 was critical in attenuating the disease progression of silicosis; however, the key signaling pathway has not yet been elucidated. Read More

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http://dx.doi.org/10.1186/s12931-018-0852-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090697PMC
August 2018
28 Reads

Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control.

Toxicol Lett 2018 Oct 21;295:357-368. Epub 2018 Jul 21.

CONICET- Universidad de Buenos Aires, Instituto de Química Biológica Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina. Buenos Aires, Argentina. Electronic address:

Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways. In Parkinson disease patients, elevated HO-1 expression levels in astrocytes are involved in antioxidant defense. In the present work, employing an in vitro model of Mn-induced Parkinsonism in astroglial C6 cells, we investigated the role of HO-1 in both apoptosis and mitochondrial quality control (MQC). Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.07.045DOI Listing
October 2018
23 Reads

A New Modality for the Diagnosis of Bleomycin-induced Toxicity: Ultrasonography.

Arch Bronconeumol 2018 Dec 19;54(12):619-624. Epub 2018 Jul 19.

Department of Chest Diseases, Dr. Lütfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey.

Objective: To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary toxicity (BT).

Material And Methods: The study included patients with suspected BT during treatment with bleomycin due to various oncologic diseases between June 2015 and May 2017. The patients initially underwent clinical and high-resolution computed tomography (HRCT) examinations and pulmonary function tests (PFT)-diffusing capacity of the lung for carbon monoxide (DLCO), followed by registration of USG findings-number of comet tail artifact (CTA) images by a different pulmonologist. Read More

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http://dx.doi.org/10.1016/j.arbres.2018.06.006DOI Listing
December 2018
11 Reads

Hyperbaric Oxygen Therapy in Liver Diseases.

Int J Med Sci 2018 22;15(8):782-787. Epub 2018 May 22.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning, decompression sickness, arterial gas embolism, problematic wound, and so on. In the liver, most studies positively evaluated HBOT as a potential therapeutic option for liver transplantation, acute liver injury, nonalcoholic steatohepatitis, fibrosis and cancer, especially for hepatic artery thrombosis. This might mainly attribute to the anti-oxidation and anti-inflammation of HBOT. Read More

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http://dx.doi.org/10.7150/ijms.24755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036079PMC
December 2018
8 Reads
2.000 Impact Factor

Cardioprotective effects of insulin on carbon monoxide-induced toxicity in male rats.

Hum Exp Toxicol 2019 Jan 12;38(1):148-154. Epub 2018 Jul 12.

1 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.

Carbon monoxide (CO) poisoning is a significant cause of death especially in developing countries. The current study investigated cardioprotective effects of insulin in CO-poisoned rats. Male rats were exposed to 3000 ppm CO for 1 h. Read More

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http://dx.doi.org/10.1177/0960327118788134DOI Listing
January 2019
2 Reads

Longitudinal Evaluation of Lung Function in Patients With Advanced Non-Small Cell Lung Cancer Treated With Concurrent Chemoradiation Therapy.

Int J Radiat Oncol Biol Phys 2018 07 12;101(4):910-918. Epub 2018 Apr 12.

Instituto Nacional de Cancerología, México City, México. Electronic address:

Purpose: In lung cancer patients, radiation therapy modifies lung architecture, resulting in functional deterioration, which worsens symptoms and reduces quality of life.

Methods And Materials: A multicenter, prospective, longitudinal study was conducted in a cohort of patients with locally advanced and oligometastatic non-small cell lung cancer treated with concurrent chemoradiation therapy (CCRT). A wide array of pulmonary function tests (forced spirometry, body plethysmography, impulse oscillometry, carbon monoxide diffusing capacity, fraction of exhaled nitric oxide, arterial blood gases, and 6-minute walk test) were used to evaluate lung function at baseline; after radiation therapy; and at 6, 12, 24, and 48 weeks after CCRT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.04.014DOI Listing
July 2018
26 Reads

Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids.

Dalton Trans 2018 Oct;47(40):14293-14303

Biophysics Unit/Center for Biophysical Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitat Autònoma de Barcelona, Avda. de Can Domènech, 08193 Cerdanyola, Spain.

New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)5L and M(CO)4L2 {L = Ph2P(CH2)6SO3Na} with the phospholipid phosphatidylcholine. The analysis of the resulting supramolecular structures using dynamic light scattering and cryo-transmission electron microscopy has shown the formation of different aggregates depending on the metallosurfactant/phospholipid ratio, as well as a significantly different behaviour between the two studied metallosurfactants. Mixed vesicles, with properties very similar to liposomes, can be obtained with both compounds, and are called metallosomes. Read More

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http://dx.doi.org/10.1039/c8dt01584hDOI Listing
October 2018
7 Reads

Recent developments in carbonylation chemistry using [ C]CO, [ C]CO, and [ C]CO.

J Labelled Comp Radiopharm 2018 Nov 28;61(13):949-987. Epub 2018 Jun 28.

Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO), Department of Chemistry, Aarhus University, Aarhus C, Denmark.

Carbon monoxide represents the most important C1-building block for the chemical industry, both for the production of bulk and fine chemicals, but also for synthetic fuels. Yet its toxicity and subsequently its cautious handling have limited its applications in medicinal chemistry research and in particular for the synthesis of pharmaceutically relevant molecules. Recent years have nevertheless witnessed a considerable headway on the development of carbon monoxide surrogates and reactor systems, which provide an ideal setting for performing carbonylation chemistry with stoichiometric and substoichiometric carbon monoxide. Read More

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http://dx.doi.org/10.1002/jlcr.3645DOI Listing
November 2018
8 Reads

[Indirect and mixed mechanisms of action in toxic myopathies].

Ann Pharm Fr 2018 Jul 24;76(4):273-285. Epub 2018 May 24.

Service de toxicologie, CHU Bab-El-Oued, rue Mohamed Lamine Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du petit Staouali Delly Brahim, 16062 Alger, Algérie.

Toxic myopathies are a group of pathologies characterized by a structural and/or functional disturbance of muscles induced by an exogenous agent. The most frequent are those induced by drugs used in clinical practice. Illegal drugs, pesticides, solvents, metals and even physical and gaseous agents can cause this kind of disease and exert toxicity on muscle tissues. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.004DOI Listing
July 2018
6 Reads

Hemin provides protection against lead neurotoxicity through heme oxygenase 1/carbon monoxide activation.

J Appl Toxicol 2018 Oct 23;38(10):1353-1364. Epub 2018 May 23.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

The neurotoxicity of lead (Pb) is well established, and oxidative stress is strongly associated with Pb-induced neurotoxicity. Heme oxygenase 1 (HO-1) is an important antioxidative enzyme for protection against oxidative stress in many disease models. In this study, we applied hemin, the substrate and a well-known inducer of HO-1, to investigate the possible role of HO-1 in protecting against Pb neurotoxicity. Read More

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http://dx.doi.org/10.1002/jat.3646DOI Listing
October 2018
3 Reads

Lethal carbon monoxide toxicity in a concrete shower unit.

Forensic Sci Med Pathol 2019 03 23;15(1):133-135. Epub 2018 May 23.

Forensic Science SA, GPO Box 2790, Adelaide, 5001, Australia.

A 47-year-old previously-well woman was found dead on the floor of a shower cubicle on a property in rural South Australia. The impression of the attending doctor and police was of collapse due to natural disease. Although there was significant stenosing coronary artery atherosclerosis found at autopsy, cherry pink discoloration of tissues prompted measurement of the blood carboxyhemoglobin level which was found to be 55%. Read More

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http://dx.doi.org/10.1007/s12024-018-9990-xDOI Listing
March 2019
5 Reads

Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity.

Dalton Trans 2018 Oct;47(40):14241-14253

School of Chemistry, Main Building, Cardiff University, Cardiff CF10 3AT, UK.

A systematic study of the cellular uptake of emissive complexes as a function of their lipophilicity is presented. Here a series of amphiphilic rhenium fac-tricarbonyl bisimine complexes bearing axial substituted imidazole or thiazole ligands, [Re(bpy)(CO)3(ImCnHm)]+ {n = 1 m = 3 (1+), n = 4 m = 9 (2+), n = 8 m = 17 (3+), n = 12 m = 25 (4+), n = 16 m = 33 (5+), n = 2 m = 3 (6+); bpy = 2,2'-bipyridine, Im = imidazole} and [Re(bpy)(CO)3(L)]+ {L = 1-mesitylimidazole, ImMes (7+), 4,5-dimethylthiazole, dmt (8+) and 4-methyl-5-thiazole-ethanol, mte (9+)} is reported. The X-ray crystal structures of 2+, 8+ and 9+ confirm the geometry and expected distribution of ligands and indicated that the plane of the imidazole/thiazole ring is approximately parallel to the long axis of the bipy ligand. Read More

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http://dx.doi.org/10.1039/c8dt00669eDOI Listing
October 2018
4 Reads

Microbial fuel cell-based biosensor for toxic carbon monoxide monitoring.

Talanta 2018 Aug 27;186:368-371. Epub 2018 Apr 27.

Department of Environmental Engineering, Technical University of Denmark, DK-2800 Lyngby, Denmark. Electronic address:

This study presents an innovative microbial fuel cell-based biosensor for carbon monoxide (CO) monitoring. The hypothesis for the function of the biosensor is that CO inhibits bacterial activity in the anode and thereby reduces electricity production. A mature electrochemically active biofilm on the anode was exposed to CO gas at varied concentrations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183044
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http://dx.doi.org/10.1016/j.talanta.2018.04.084DOI Listing
August 2018
22 Reads
3.545 Impact Factor

Genotoxicity evaluation of carbon monoxide and 1,3-butadiene using a new joint technology: the in vitro γH2AX HCS assay combined with air-liquid interface system.

Toxicol Mech Methods 2019 Jan 29;29(1):1-7. Epub 2018 Nov 29.

a China National Tobacco Quality Supervision and Test Center , Zhengzhou , P.R. China.

To investigate the genotoxicity of gaseous toxicants carbon monoxide (CO) and 1,3-butadiene in vitro, a novel combination technology-the in vitro γH2AX high content screening assay combined with air-liquid interface system (ALIS) was established. The results showed that this new technology was available and effective. Based on the joint technology, genotoxicity of CO and 1,3-butadiene was evaluated further in this study. Read More

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http://dx.doi.org/10.1080/15376516.2018.1477897DOI Listing
January 2019
16 Reads