2,716 results match your criteria Toxicity Carbon Monoxide

Gas Expansion Three Days after Pars Plana Vitrectomy with Sulfur Hexafluoride 20% Tamponade following Carbon Monoxide Toxicity and Oxygen Therapy.

Case Rep Ophthalmol Med 2022 9;2022:5035361. Epub 2022 May 9.

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To report an unusual case of gas expansion following oxygen therapy in a patient with sulfur hexafluoride (SF) 20% tamponade after pars plana vitrectomy. . A 40-year-old man came to the clinic with severe ocular pain and redness and also vision decrease in his left eye three days after uncomplicated 23-gauge pars plana vitrectomy, internal limiting membrane peeling combined with phacoemulsification, and using 20% SF injection as a tamponade agent due to significant cataract and a full-thickness macular hole. Read More

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Exposure to lead-free frangible firing emissions containing copper and ultrafine particulates leads to increased oxidative stress in firing range instructors.

Part Fibre Toxicol 2022 May 15;19(1):36. Epub 2022 May 15.

711th Human Performance Wing, Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, OH, USA.

Background: Since the introduction of copper based, lead-free frangible (LFF) ammunition to Air Force small arms firing ranges, instructors have reported symptoms including chest tightness, respiratory irritation, and metallic taste. These symptoms have been reported despite measurements determining that instructor exposure does not exceed established occupational exposure limits (OELs). The disconnect between reported symptoms and exposure limits may be due to a limited understanding of LFF firing byproducts and subsequent health effects. Read More

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Carbon Monoxide Toxicity.

Emerg Med Clin North Am 2022 May 5;40(2):283-312. Epub 2022 Apr 5.

Department of Emergency Medicine, Medical Toxicology, Indiana University School of Medicine, Indiana Poison Center, 1701 North Senate Boulevard, B412a, Indianapolis, IN 46202, USA.

Carbon monoxide accounts for thousands of deaths worldwide each year. Clinical effects can be diverse and include headache, dizziness, nausea, vomiting, syncope, seizures, coma, dysrhythmias, and cardiac ischemia, and severe toxicity generally affects the nervous and cardiovascular systems. Because of its complex pathophysiology, effects of toxicity can be acute or delayed. Read More

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Hydrogen sulfide and metal interaction: the pathophysiological implications.

Mol Cell Biochem 2022 Apr 24. Epub 2022 Apr 24.

School of Natural Sciences, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada.

Hydrogen sulfide (HS), previously recognized as a toxic gas, has emerged as an important gaseous signaling molecule along with nitric oxide, carbon monoxide and also hydrogen. HS can be endogenously produced in the mammalian body at a very low level for various pathophysiological processes. Notably, HS can interact with several essential metals in the body such as iron, copper, nickel, and zinc to carry out specific functions. Read More

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TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment.

Antioxidants (Basel) 2022 Apr 12;11(4). Epub 2022 Apr 12.

Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.

Relapse in multiple myeloma (MM) decreases therapy efficiency through unclear mechanisms of chemoresistance. Since our group previously demonstrated that heme oxygenase-1 (HO-1) and Toll-like receptor 4 (TLR4) are two signaling pathways protecting MM cells from the proteasome inhibitor bortezomib (BTZ), we here evaluated their cross-regulation by a pharmacological approach. We found that cell toxicity and mitochondrial depolarization by BTZ were increased upon inhibition of HO-1 and TLR4 by using tin protoporphyrin IX (SnPP) and TAK-242, respectively. Read More

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Pooled analysis on image-guided moderately hypofractionated thoracic irradiation in inoperable node-positive/recurrent patients with non-small cell lung cancer with poor prognostic factors and severely limited pulmonary function and reserve.

Cancer 2022 Jun 13;128(12):2358-2366. Epub 2022 Apr 13.

Department of Radiation Oncology, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Background: The objective of this study was to investigate the feasibility and efficacy of image-guided moderately hypofractionated thoracic radiotherapy (hypo-IGRT) in patients with non-small cell lung cancer (NSCLC) with poor performance status and severely limited pulmonary function and reserve.

Methods: Consecutive inoperable patients who had node-positive, stage IIB-IIIC (TNM, 8th edition) or recurrent NSCLC, had an Eastern Cooperative Oncology Group performance status ≥1, and had a forced expiratory volume in 1 second (FEV ) ≤1.0 L, had a single-breath diffusing capacity of the lung for carbon monoxide (DLCO-SB) ≤40% and/or on long-term oxygen therapy were analyzed. Read More

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A PEGylated water-soluble fluorescent and colorimetric probe for carbon monoxide detection.

Analyst 2022 May 3;147(9):1798-1802. Epub 2022 May 3.

College of Medical Laboratory, Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.

A CO probe with PEGylation is synthesized, achieving the detection of CO in pure water solution with high intensity color change and fluorescence enhancement. Importantly, this probe with high affinity to paper strips and low toxicity to living cells is successfully used for sensing CO in air and in living cells. Read More

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Prospective Study of Proton Therapy for Lung Cancer Patients with Poor Lung Function or Pulmonary Fibrosis.

Cancers (Basel) 2022 Mar 11;14(6). Epub 2022 Mar 11.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

PBT has a unique depth-dose curve with a Bragg peak that enables one to reduce the dose to normal lung tissue. We prospectively enrolled 54 patients with non-small cell lung cancer treated with definitive PBT. The inclusion criteria were forced expiratory volume in 1 s (FEV1) ≤ 1. Read More

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A novel precipitating-fluorochrome-based fluorescent probe for monitoring carbon monoxide during drug-induced liver injury.

Talanta 2022 Jun 18;243:123398. Epub 2022 Mar 18.

Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China. Electronic address:

Carbon monoxide (CO), as one of significant gas transmitter, is closely associated with a variety of physiological and pathological processes. Although plenty of fluorescent probes have been prepared for detecting CO, most of them suffer from water-soluble fluorophores and short emission wavelength, which tends to diffuse and is limited to apply in vivo. Herein, a novel water-soluble fluorescent probe (HPQ-MQ-CO) is prepared to detect CO by releasing a precipitating fluorochrome (HPQ-MQ-OH), which is developed by introducing the 1-ethyl-2-methylquinoline group into HPQ to obtain long emission wavelength and good diffusion resistant ability. Read More

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Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning.

Metabolites 2022 Feb 24;12(3). Epub 2022 Feb 24.

Mitohormesis Research Center, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea.

Mitochondrial and oxidative stress play critical roles in the pathogenic mechanisms of carbon monoxide (CO)-induced toxicity. This study was designed to evaluate whether the serum levels of specific stress biomarkers might reflect brain injury and act as prognostic markers for the development of neurocognitive sequelae following CO poisoning. We analyzed the data from 51 adult patients admitted with acute CO poisoning and measured the serum level expression of growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21), indicators of mitochondrial stress, and 8-Oxo-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), indicators of oxidative stress. Read More

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February 2022

Influence of Dexamethasone Premedication on Acute Lung Toxicity in Lung SBRT.

Front Oncol 2022 28;12:837577. Epub 2022 Feb 28.

Department of Radiation Oncology, Geisinger Cancer Institute, Danville, PA, United States.

Introduction: The cooperative group experience of thoracic sterotactic body radiation therapy (SBRT) in medically inoperable patients with early stage non-small cell lung cancer (NSCLC) historically utilized corticosteroid premedication. Patterns of care have been mixed as to whether premedication adds benefit in terms of improved lung toxicity and treatment tolerance.

Methods: Patients treated for NSCLC from 2014 to 2017 with definitive thoracic SBRT (BED≥100) at a single institution, in a prospectively collected database were evaluated. Read More

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February 2022

Structure-Photoreactivity Relationship of 3-Hydroxyflavone-Based CO-Releasing Molecules.

J Org Chem 2022 Apr 13;87(7):4750-4763. Epub 2022 Mar 13.

Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.

Carbon monoxide (CO) is an endogenous signaling molecule that regulates diverse physiological processes. The therapeutic potential of CO is hampered by its intrinsic toxicity, and its administration poses a significant challenge. Photoactivatable CO-releasing molecules (photoCORMs) are an excellent tool to overcome the side effects of untargeted CO administration and provide precise spatial and temporal control over its release. Read More

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Acute carbon monoxide poisoning in Shandong, China: an observational study.

Chin Med J (Engl) 2022 Feb 15. Epub 2022 Feb 15.

Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, China.

Background: Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.

Methods: We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases. Read More

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February 2022

Prenatal and early life exposure to air pollution and the incidence of Kawasaki disease.

Sci Rep 2022 03 1;12(1):3415. Epub 2022 Mar 1.

Children's Medical Center, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sec. 4, Taichung, 40705, Taiwan, ROC.

Kawasaki disease (KD) is the most common form of acquired pediatric cardiac disease in the developed world. However, its etiology is still unclear. Epidemiological studies have shown that air pollution is a plausible risk factor in stimulating oxidative stress, inducing inflammation and causing autoimmune diseases. Read More

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Controlled human exposure to diesel exhaust: a method for understanding health effects of traffic-related air pollution.

Part Fibre Toxicol 2022 02 25;19(1):15. Epub 2022 Feb 25.

Department of Medicine, Division of Respiratory Medicine, University of British Columbia, 2775 Laurel Street 7th Floor, Vancouver, BC, V5Z 1M9, Canada.

Diesel exhaust (DE) is a major component of air pollution in urban centers. Controlled human exposure (CHE) experiments are commonly used to investigate the acute effects of DE inhalation specifically and also as a paradigm for investigating responses to traffic-related air pollution (TRAP) more generally. Given the critical role this model plays in our understanding of TRAP's health effects mechanistically and in support of associated policy and regulation, we review the methodology of CHE to DE (CHE-DE) in detail to distill critical elements so that the results of these studies can be understood in context. Read More

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February 2022

Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea.

Int J Environ Res Public Health 2022 02 19;19(4). Epub 2022 Feb 19.

School of the Environment, Yale University, New Haven, CT 06511, USA.

Bone health is a major concern for aging populations globally. Osteoporosis and bone mineral density are associated with air pollution, but less is known about the impacts of air pollution on osteoporotic fracture. We aimed to assess the associations between long-term air pollution exposure and risk of osteoporotic fracture in seven large Korean cities. Read More

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February 2022

The association between short-term exposure to ambient carbon monoxide and hospitalization costs for bronchitis patients: A hospital-based study.

Environ Res 2022 Jul 21;210:112945. Epub 2022 Feb 21.

Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, China. Electronic address:

Ambient carbon monoxide (CO) is associated with bronchitis morbidity, but there is no evidence concerning its correlation with hospitalization costs for bronchitis patients. This study aimed to investigate the relationship between short-term ambient CO exposure and hospitalization costs for bronchitis patients in Chongqing, China. Baseline data for 3162 hospitalized bronchitis patients from November 2013 to December 2019 were collected. Read More

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A NIR-emissive probe with a remarkable Stokes shift for CO-releasing molecule-3 detection in cells and .

Analyst 2022 Mar 14;147(6):1169-1174. Epub 2022 Mar 14.

Cancer Research Institute, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, China.

Carbon monoxide (CO) is regarded as one of the most important gaseous transmitters, playing a vital role in biological systems; meanwhile, abnormal levels of CO can be correlated with conditions such as lung disease, Alzheimer's disease, and cardiovascular disease. CO-releasing molecules (CORMs) are chemical agents used to release CO as an endogenous, biologically active molecule in order to treat diseases. CO-releasing molecule-3 (CORM-3), as a convenient and safe CO donor and therapeutic drug molecule, has been widely used to release exogenous CO in living cells to study the physiological and pathological roles of CO in living systems. Read More

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Does air pollution modify temperature-related mortality? A systematic review and meta-analysis.

Environ Res 2022 Jul 16;210:112898. Epub 2022 Feb 16.

Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, 38 Xueyuan Road, Haidian District, Beijing, 100191, China. Electronic address:

Introduction: There is an increasing interest in understanding whether air pollutants modify the quantitative relationships between temperature and health outcomes. The results of available studies were, however, inconsistent. This study aims to sum up the current evidence and provide a comprehensive understanding of this topic. Read More

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Endogenous carbon monoxide due to hemolytic anemia: A forensic red herring.

J Forensic Sci 2022 May 18;67(3):1294-1299. Epub 2022 Feb 18.

North Carolina Office of the Chief Medical Examiner, Raleigh, North Carolina, USA.

Carbon monoxide (CO) toxicity associated with exposure to an environmental, exogenous source, is routinely investigated in the field of forensics. Paramedics responded to the home of a 60-year-old woman who complained of persistent nausea, dizziness, and fatigue. Her initial carboxyhemoglobin (COHb) saturation was 25% as measured by paramedics in the field via pulse CO-oximetry (SpCO) and was, 2 hours later, confirmed by hospital laboratory spectrophotometric analysis to be 16% after initial treatment in the emergency department. Read More

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Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization.

ACS Med Chem Lett 2022 Feb 1;13(2):236-242. Epub 2022 Feb 1.

Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322-0300, United States.

Light-triggered carbon monoxide (CO) delivery molecules are of significant current interest for evaluating the role of CO in biology and as potential therapeutics. Herein we report the first example of a metal free CO delivery molecule that can be tracked via confocal microscopy at low micromolar concentrations in cells prior to CO release. The NEt-appended extended flavonol () localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Read More

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February 2022

Scalable manufacturing platform for the production of methemoglobin as a non-oxygen carrying control material in studies of cell-free hemoglobin solutions.

PLoS One 2022 16;17(2):e0263782. Epub 2022 Feb 16.

William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, United States of America.

Methemoglobin (metHb) arises from the oxidation of ferrous hemoglobin (HbFe2+, Hb) to ferric hemoglobin (HbFe3+, metHb), which is unable to bind gaseous ligands such as oxygen (O2) and carbon monoxide (CO), and binds to nitric oxide (NO) significantly slower compared to Hb. Therefore, metHb does not elicit vasoconstriction and systemic hypertension in vivo due to its extremely slow NO scavenging rate in comparison to cell-free Hb, but will induce oxidative tissue injury, demonstrating the potential of using metHb as a control material when studying the toxicity of cell-free Hb. Hence, the goal of this work was to develop a novel manufacturing strategy for production of metHb that is amenable to scale-up. Read More

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February 2022

Antiproliferative and Cytotoxic Activities of Fluorescein-A Diagnostic Angiography Dye.

Int J Mol Sci 2022 Jan 28;23(3). Epub 2022 Jan 28.

Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and 1st Faculty of Medicine, Charles University, Na Bojišti 3, 121 08 Praha, Czech Republic.

Fluorescein is a fluorescent dye used as a diagnostic tool in various fields of medicine. Although fluorescein itself possesses low toxicity, after photoactivation, it releases potentially toxic molecules, such as singlet oxygen (O) and, as we demonstrate in this work, also carbon monoxide (CO). As both of these molecules can affect physiological processes, the main aim of this study was to explore the potential biological impacts of fluorescein photochemistry. Read More

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January 2022

Cold Climate Impact on Air-Pollution-Related Health Outcomes: A Scoping Review.

Int J Environ Res Public Health 2022 01 28;19(3). Epub 2022 Jan 28.

Department of Mechanical Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada.

In cold temperatures, vehicles idle more, have high cold-start emissions including greenhouse gases, and have less effective exhaust filtration systems, which can cause up to ten-fold more harmful vehicular emissions. Only a few vehicle technologies have been tested for emissions below -7 °C (20 °F). Four-hundred-million people living in cities with sub-zero temperatures may be impacted. Read More

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January 2022

Proteomic Analysis of Swertiamarin-treated BV-2 Cells and Possible Implications in Neuroinflammation.

J Oleo Sci 2022 Mar 11;71(3):395-400. Epub 2022 Feb 11.

Department of Geriatrics, Affiliated Hospital of Inner Mongolia University for Nationalities.

The purpose of this study was to explore the neuroprotective role of swertiamarin on neuro-inflammation, and analyzed its potential mechanism by proteomics. We used LPS to induce a inflammatory model on BV-2 cells, then 10, 25, 50 μg/mL swertiamarin was used to treat the LPS pretreated BV-2 cells. We used ELISA to detect the effect of swertiamarin on the expression of inflammation related indicators such as IL-1β, il-6, IL-18 and TNF-α. Read More

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Platelet-to-Lymphocyte Ratio as an Indicator to Predict Decreased Carbon Monoxide Diffusion of the Lung in Patients with Testicular Cancer.

J Coll Physicians Surg Pak 2022 Mar;32(3):369-372

Department of Medical Oncology, Oncology Education and Research Hospital, Ankara, Turkey.

Objective: To investigate whether the use of diffusing capacity of the lungs for carbon monoxide (DLCO) and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) could be used to predict bleomycin-induced pulmonary toxicity in patients with testicular cancer (TCa).

Study Design: Descriptive study.

Place And Duration Of Study: Ankara Oncology Training and Research Hospital, Turkey, between 2017 and 2020. Read More

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Cadmium induces the expression of Interleukin-6 through Heme Oxygenase-1 in HK-2 cells and Sprague-Dawley rats.

Food Chem Toxicol 2022 Mar 2;161:112846. Epub 2022 Feb 2.

Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City, Taiwan. Electronic address:

Cadmium is toxic to the kidney through mechanisms involving oxidative stress and inflammation. We studied reciprocal crosstalk among the oxidative stress, inflammation, and the nuclear Nrf2 pathway in cadmium-induced nephrotoxicity on HK-2 human renal proximal tubular epithelial cells. Cadmium chloride (CdCl) caused cell viability loss, Reactive Oxygen Species (ROS) generation, glutathione reduction, and Interleukin-6 (IL-6) expression, accompanied by Nrf2 activation and Heme Oxygenase-1 (HO-1) expression. Read More

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Smoke inhalation injury: a narrative review.

Rita Galeiras

Mediastinum 2021 25;5:16. Epub 2021 Jun 25.

Complexo Hospitalario Universitario, A Coruna, Spain; Burn Unit, Instituto de Investigacion Biomedica de A Coruna, A Coruna, Spain.

Burn Units frequently provide care to patients who have burn injuries and concomitant smoke inhalation injury. Inhalation damage is a complex multifaceted lung and systemic disease process, and the leading cause of mortality and morbidity in victims of fire tragedies. The degree of airway injury depends on the composition of smoke and the duration of smoke exposure. Read More

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X-ray-Triggered CO Release Based on GdW/MnBr(CO) Nanomicelles for Synergistic Radiotherapy and Gas Therapy.

ACS Appl Mater Interfaces 2022 Feb 2;14(6):7636-7645. Epub 2022 Feb 2.

School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, China.

Carbon monoxide (CO) therapy has become a hot topic in the field of gas therapy because of its application prospect in the treatment of various diseases. Due to the high affinity for human hemoglobin, the main challenge of CO-loaded nanomedicine is the lack of selectivity and toxicity in the delivery process. Although many commercial CO-releasing molecules (CORMs) have been widely developed because of their ability to deliver CO, CORMs still have some disadvantages, including difficult on-demand controlled CO release, poor solubility, and potential toxicity, which are limiting their further application. Read More

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February 2022

Association between traffic-related air pollution and anxiety hospitalizations in a coastal Chinese city: are there potentially susceptible groups?

Environ Res 2022 Jun 29;209:112832. Epub 2022 Jan 29.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China. Electronic address:

Motor vehicle exhaust emissions have become the main source of urban air pollution in China, but few studies have explored the association of short-term exposure to traffic-related air pollutants (TRAPs) with anxiety disorders. Thus, we used an overdispersed, generalized additive model (GAM) to investigate the association between TRAPs and hospital admissions (HAs) for anxiety in Qingdao, a coastal Chinese city with high vehicle ownership. In addition, stratified analyses were performed by gender, age, season and hospitalization frequency (first admission and readmission). Read More

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