2,384 results match your criteria Toxicity Carbon Monoxide


Lung function changes after chemoradiation therapy in patients with lung cancer treated by three usual platinum combinations.

J Thorac Dis 2018 Sep;10(9):5435-5442

Departments of Respiratory Medicine, Medical School Democritus University of Thrace, Alexandroupolis, Greece.

Background: Reports point out lung toxicity of chemotherapeutic agents and radiation therapy in cancer patients. The aim of our study was to assess lung function after sequential chemoradiation therapy in patients with lung cancer.

Methods: Fifteen lung cancer patients participated the study and underwent lung function assessment before and after sequential treatment of chemotherapy with the 3 most applied platinum-based combinations: of vinorelbine (VN) 6 patients, gemcitabine (GEM) 4 patients and etoposide (EP) 5 patients and radiation therapy. Read More

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http://jtd.amegroups.com/article/view/23954/18345
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http://dx.doi.org/10.21037/jtd.2018.08.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196207PMC
September 2018
13 Reads

Carbon monoxide attenuates amyloidogenesis via down-regulation of NF-κB-mediated BACE1 gene expression.

Aging Cell 2018 Nov 9:e12864. Epub 2018 Nov 9.

Meta-Inflammation Research Institute of Basic Research, School of Biological Sciences, University of Ulsan, Ulsan, South Korea.

Amyloid-β (Aβ) peptides, the major constituent of plaques, are generated by sequential proteolytic cleavage of the amyloid precursor protein (APP) via β-secretase (BACE1) and the γ-secretase complex. It has been proposed that the abnormal secretion and accumulation of Aβ are the initial causative events in the development of Alzheimer's disease (AD). Drugs modulating this pathway could be used for AD treatment. Read More

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http://doi.wiley.com/10.1111/acel.12864
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http://dx.doi.org/10.1111/acel.12864DOI Listing
November 2018
5 Reads

Exhaled carbon monoxide levels correlate with incidence of oral mucosal lesions independent of smoking status.

Int J Environ Health Res 2018 Oct 30:1-11. Epub 2018 Oct 30.

b Department of Angiology , Jagiellonian University Medical College , Krakow , Poland.

Carbon monoxide (CO) is an important component of tobacco smoke, but also environmental toxicity. This study analyzed possible correlation between exhaled CO level and oral health indicators in two geographically distributed populations during health-promoting public events organized for local communities in cities with high and low environmental pollution in Poland (907 patients). Self-reported, instructor-led, oral health questionnaire was developed to monitor current and previous mucosal lesion incidence. Read More

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http://dx.doi.org/10.1080/09603123.2018.1541442DOI Listing
October 2018
1 Read

Total Blood Carbon Monoxide: Alternative to Carboxyhemoglobin as Biological Marker for Carbon Monoxide Poisoning Determination.

Authors:
S Oliverio V Varlet

J Anal Toxicol 2018 Oct 29. Epub 2018 Oct 29.

Forensic Toxicology and Chemistry Unit, University Centre of Legal Medicine Lausanne-Geneva, Chemin de la Vulliette 4, Lausanne, Switzerland.

As one of the most abundant toxic contaminants in the atmosphere, carbon monoxide (CO) plays a significant role in toxicology and public health. Every year, around half of the accidental non-fire-related poisoning deaths are attributed to CO in the USA, UK and many other countries. However, due to the non-specificity of the symptoms and often encountered inconsistency of these with the results obtained from measurements of the biomarker for CO poisonings, carboxyhemoglobin (COHb), there is a high rate of misdiagnoses. Read More

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https://academic.oup.com/jat/advance-article/doi/10.1093/jat
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http://dx.doi.org/10.1093/jat/bky084DOI Listing
October 2018
5 Reads

Biocides Used as Additives to Biodiesels and Their Risks to the Environment and Public Health: A Review.

Molecules 2018 Oct 19;23(10). Epub 2018 Oct 19.

Postgraduate Program in Biomedical Engineering, Campus Gama (FGA), University of Brasília (UnB), Brasília 72.444-240, Brazil.

One of the advantages of using biodiesel and its blends with diesel oil is the lower levels of emissions of particulate matter, sulfur dioxide, carbon monoxide, among others, making it less harmful to the environment and to humans. However, this biofuel is susceptible to microbial contamination and biodeterioration. In this sense, studies on the use of effective low toxicity biocides are being carried out, and this work aims to present the latest information (2008⁻2018) available in the scientific databases, on the use of biocides in biodiesel, mainly concerning their toxicity to the environment and public health. Read More

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http://dx.doi.org/10.3390/molecules23102698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222844PMC
October 2018
1 Read

Synthesis, toxicities and bio-activities of manganese complexes with CO and HS dual donors.

Eur J Med Chem 2018 Nov 4;159:339-356. Epub 2018 Oct 4.

School of Stomatology of Lanzhou University; Lanzhou, 730000, China.

A series of HSCO dual-donors [Mn(CO)CSNRR] was synthesized, and evaluated from toxicity and bioactivity. The COHS measuring test showed all the complexes not only released CO, but released HS. The resulting data of cytotoxicity showed all the complexes had activities against the cell proliferation; among them, complexes 1, 2 and 7 displayed higher activities than the others, and their potencies were close to cis-platinum (DDP); whereas the precursors A-A had almost no activities against all five tumor cell lines and W138 cell line proliferation. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.10.004DOI Listing
November 2018
2 Reads
3.450 Impact Factor

Sodium nitrite food poisoning in one family.

Forensic Sci Med Pathol 2018 Oct 6. Epub 2018 Oct 6.

Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str, Belgrade, 11000, Serbia.

Sodium nitrite is used as a coloring agent or preservative in food, as well as an antimicrobial agent in meat and fish and some cheeses. In high amounts it can be toxic for humans, causing methemoglobinemia. This is an unusual and potentially fatal condition in which hemoglobin is oxidized to methemoglobin (MHb), reducing the amount of oxygen that is released from hemoglobin, similar to carbon monoxide poisoning. Read More

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http://link.springer.com/10.1007/s12024-018-0036-1
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http://dx.doi.org/10.1007/s12024-018-0036-1DOI Listing
October 2018
5 Reads

Association of fine particulate matter on acute exacerbation of chronic obstructive pulmonary disease in Yancheng, China.

Sci Total Environ 2019 Feb 22;650(Pt 2):1665-1670. Epub 2018 Sep 22.

Department of Respiratory Medicine, the First People's Hospital of Yancheng, the Fourth Affiliated Hospital of Nantong University, Jiangsu Province 224006, China. Electronic address:

Background: Epidemiological evidence on the association between short-term exposure to fine particulate matter (PM) air pollution and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is limited in China.

Objectives: To explore the associations between PM and AECOPD in Yancheng, China from 2015 to 2017.

Methods: In this time-series study, we used a generalized linear model with quasi-Poisson regression to investigate the association between PM and AECOPD admitted in two major hospitals in Yancheng. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.278DOI Listing
February 2019
2 Reads

Mechanisms of toxic cardiomyopathy.

Authors:
Philippe Hantson

Clin Toxicol (Phila) 2018 Sep 27:1-9. Epub 2018 Sep 27.

a Department of Intensive Care , Cliniques St-Luc, Université catholique de Louvain , Brussels , Belgium.

Background: Dilated cardiomyopathy is a frequent disease responsible for 40-50% of cases of heart failure. Idiopathic cardiomyopathy is a primary disorder often related to familial/genetic predisposition. Before the diagnosis of idiopathic cardiomyopathy is made, clinicians must not only rule out viral and immune causes, but also toxic causes such as drugs, environmental agents, illicit substances and natural toxins. Read More

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http://dx.doi.org/10.1080/15563650.2018.1497172DOI Listing
September 2018
8 Reads

The porcine odorant-binding protein as molecular probe for benzene detection.

PLoS One 2018 5;13(9):e0202630. Epub 2018 Sep 5.

Institute of Food Science, Consiglio Nazionale delle Ricerche, Avellino, Italy.

In recent years, air pollution has been a subject of great scientific and public interests for the strong impact on human health. Air pollution is due to the presence in the atmosphere of polluting substances, such as carbon monoxide, sulfur and nitrogen oxides, particulates and volatile organic compounds (VOCs), derived predominantly from various combustion processes. Benzene is a VOC belonging to group-I carcinogens with a toxicity widely demonstrated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124761PMC
September 2018
7 Reads

Hydrogen sulphide trapeze: Environmental stress amelioration and phytohormone crosstalk.

Plant Physiol Biochem 2018 Nov 24;132:46-53. Epub 2018 Aug 24.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, 700016, West Bengal, India. Electronic address:

Hydrogen sulphide (HS) is recognized as the third endogenous gasotransmitter in plants after nitric oxide (NO) and carbon monoxide (CO). Though initially visualized as a toxic gaseous molecule, recent studies have illustrated its diverse role in regulating plant growth and developmental physiology. HS is also a potent inducer of osmolytes and cellular antioxidants of enzymatic and non-enzymatic origins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09819428183038
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http://dx.doi.org/10.1016/j.plaphy.2018.08.028DOI Listing
November 2018
9 Reads

Differences in puff topography, toxicant exposure, and subjective response between waterpipe tobacco smoking men and women.

Exp Clin Psychopharmacol 2018 Oct 13;26(5):440-447. Epub 2018 Aug 13.

Department of Psychology.

Waterpipe tobacco smoking (WTS) exposes users to toxicants in much greater amounts than a cigarette. Little is known about how gender affects WTS toxicant exposure and subjective response. Data from three WTS clinical laboratory studies were combined for analysis. Read More

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http://dx.doi.org/10.1037/pha0000207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162145PMC
October 2018

Combustion Behaviors of CIGS Thin-Film Solar Modules from Cone Calorimeter Tests.

Materials (Basel) 2018 Aug 4;11(8). Epub 2018 Aug 4.

State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, China.

As is well known, building integrated photovoltaic (BIPV) technology is becoming more commonly used in residential and commercial buildings. Fire assessment of photovoltaic (PV) modules as a whole is still insufficient. This work focuses on the thermal properties and combustion behavior of CIGS (copper, indium, gallium and selenium) thin-film modules. Read More

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http://dx.doi.org/10.3390/ma11081353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119912PMC
August 2018
1 Read

Regulatory role of heme oxygenase-1 in silica-induced lung injury.

Respir Res 2018 08 1;19(1):144. Epub 2018 Aug 1.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.

Background: Silicosis, a progressive inflammatory lung disease attributed mainly to occupational exposure to silica dust, shows loss of lung function even after cessation of exposure. In addition to conventional evaluation methods such as chest X-ray, computed tomography, and spirometry, we identified heme oxygenase (HO)-1, an inducible antioxidant, as a potential biomarker to identify at-risk patients. We found that HO-1 was critical in attenuating the disease progression of silicosis; however, the key signaling pathway has not yet been elucidated. Read More

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http://dx.doi.org/10.1186/s12931-018-0852-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090697PMC
August 2018
10 Reads

Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control.

Toxicol Lett 2018 Oct 21;295:357-368. Epub 2018 Jul 21.

CONICET- Universidad de Buenos Aires, Instituto de Química Biológica Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina. Buenos Aires, Argentina. Electronic address:

Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways. In Parkinson disease patients, elevated HO-1 expression levels in astrocytes are involved in antioxidant defense. In the present work, employing an in vitro model of Mn-induced Parkinsonism in astroglial C6 cells, we investigated the role of HO-1 in both apoptosis and mitochondrial quality control (MQC). Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.07.045DOI Listing
October 2018
21 Reads

A New Modality for the Diagnosis of Bleomycin-induced Toxicity: Ultrasonography.

Arch Bronconeumol 2018 Dec 19;54(12):619-624. Epub 2018 Jul 19.

Department of Chest Diseases, Dr. Lütfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey.

Objective: To evaluate the role of ultrasonography (USG) in the diagnosis of bleomycin-induced pulmonary toxicity (BT).

Material And Methods: The study included patients with suspected BT during treatment with bleomycin due to various oncologic diseases between June 2015 and May 2017. The patients initially underwent clinical and high-resolution computed tomography (HRCT) examinations and pulmonary function tests (PFT)-diffusing capacity of the lung for carbon monoxide (DLCO), followed by registration of USG findings-number of comet tail artifact (CTA) images by a different pulmonologist. Read More

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http://dx.doi.org/10.1016/j.arbres.2018.06.006DOI Listing
December 2018
4 Reads

Hyperbaric Oxygen Therapy in Liver Diseases.

Int J Med Sci 2018 22;15(8):782-787. Epub 2018 May 22.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning, decompression sickness, arterial gas embolism, problematic wound, and so on. In the liver, most studies positively evaluated HBOT as a potential therapeutic option for liver transplantation, acute liver injury, nonalcoholic steatohepatitis, fibrosis and cancer, especially for hepatic artery thrombosis. This might mainly attribute to the anti-oxidation and anti-inflammation of HBOT. Read More

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http://dx.doi.org/10.7150/ijms.24755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036079PMC
December 2018
7 Reads
2.000 Impact Factor

Cardioprotective effects of insulin on carbon monoxide-induced toxicity in male rats.

Hum Exp Toxicol 2018 Jan 1:960327118788134. Epub 2018 Jan 1.

1 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.

Carbon monoxide (CO) poisoning is a significant cause of death especially in developing countries. The current study investigated cardioprotective effects of insulin in CO-poisoned rats. Male rats were exposed to 3000 ppm CO for 1 h. Read More

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http://dx.doi.org/10.1177/0960327118788134DOI Listing
January 2018

Longitudinal Evaluation of Lung Function in Patients With Advanced Non-Small Cell Lung Cancer Treated With Concurrent Chemoradiation Therapy.

Int J Radiat Oncol Biol Phys 2018 Jul 12;101(4):910-918. Epub 2018 Apr 12.

Instituto Nacional de Cancerología, México City, México. Electronic address:

Purpose: In lung cancer patients, radiation therapy modifies lung architecture, resulting in functional deterioration, which worsens symptoms and reduces quality of life.

Methods And Materials: A multicenter, prospective, longitudinal study was conducted in a cohort of patients with locally advanced and oligometastatic non-small cell lung cancer treated with concurrent chemoradiation therapy (CCRT). A wide array of pulmonary function tests (forced spirometry, body plethysmography, impulse oscillometry, carbon monoxide diffusing capacity, fraction of exhaled nitric oxide, arterial blood gases, and 6-minute walk test) were used to evaluate lung function at baseline; after radiation therapy; and at 6, 12, 24, and 48 weeks after CCRT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.04.014DOI Listing
July 2018
12 Reads

Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids.

Dalton Trans 2018 Oct;47(40):14293-14303

Biophysics Unit/Center for Biophysical Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitat Autònoma de Barcelona, Avda. de Can Domènech, 08193 Cerdanyola, Spain.

New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)5L and M(CO)4L2 {L = Ph2P(CH2)6SO3Na} with the phospholipid phosphatidylcholine. The analysis of the resulting supramolecular structures using dynamic light scattering and cryo-transmission electron microscopy has shown the formation of different aggregates depending on the metallosurfactant/phospholipid ratio, as well as a significantly different behaviour between the two studied metallosurfactants. Mixed vesicles, with properties very similar to liposomes, can be obtained with both compounds, and are called metallosomes. Read More

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http://dx.doi.org/10.1039/c8dt01584hDOI Listing
October 2018
4 Reads

Recent developments in carbonylation chemistry using [ C]CO, [ C]CO, and [ C]CO.

J Labelled Comp Radiopharm 2018 Nov 28;61(13):949-987. Epub 2018 Jun 28.

Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO), Department of Chemistry, Aarhus University, Aarhus C, Denmark.

Carbon monoxide represents the most important C1-building block for the chemical industry, both for the production of bulk and fine chemicals, but also for synthetic fuels. Yet its toxicity and subsequently its cautious handling have limited its applications in medicinal chemistry research and in particular for the synthesis of pharmaceutically relevant molecules. Recent years have nevertheless witnessed a considerable headway on the development of carbon monoxide surrogates and reactor systems, which provide an ideal setting for performing carbonylation chemistry with stoichiometric and substoichiometric carbon monoxide. Read More

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http://dx.doi.org/10.1002/jlcr.3645DOI Listing
November 2018
3 Reads

[Indirect and mixed mechanisms of action in toxic myopathies].

Ann Pharm Fr 2018 Jul 24;76(4):273-285. Epub 2018 May 24.

Service de toxicologie, CHU Bab-El-Oued, rue Mohamed Lamine Debaghine, 16009 Alger, Algérie; Centre national de toxicologie, route du petit Staouali Delly Brahim, 16062 Alger, Algérie.

Toxic myopathies are a group of pathologies characterized by a structural and/or functional disturbance of muscles induced by an exogenous agent. The most frequent are those induced by drugs used in clinical practice. Illegal drugs, pesticides, solvents, metals and even physical and gaseous agents can cause this kind of disease and exert toxicity on muscle tissues. Read More

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http://dx.doi.org/10.1016/j.pharma.2018.03.004DOI Listing
July 2018
4 Reads

Hemin provides protection against lead neurotoxicity through heme oxygenase 1/carbon monoxide activation.

J Appl Toxicol 2018 Oct 23;38(10):1353-1364. Epub 2018 May 23.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

The neurotoxicity of lead (Pb) is well established, and oxidative stress is strongly associated with Pb-induced neurotoxicity. Heme oxygenase 1 (HO-1) is an important antioxidative enzyme for protection against oxidative stress in many disease models. In this study, we applied hemin, the substrate and a well-known inducer of HO-1, to investigate the possible role of HO-1 in protecting against Pb neurotoxicity. Read More

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http://dx.doi.org/10.1002/jat.3646DOI Listing
October 2018
2 Reads

Lethal carbon monoxide toxicity in a concrete shower unit.

Forensic Sci Med Pathol 2018 May 23. Epub 2018 May 23.

Forensic Science SA, GPO Box 2790, Adelaide, 5001, Australia.

A 47-year-old previously-well woman was found dead on the floor of a shower cubicle on a property in rural South Australia. The impression of the attending doctor and police was of collapse due to natural disease. Although there was significant stenosing coronary artery atherosclerosis found at autopsy, cherry pink discoloration of tissues prompted measurement of the blood carboxyhemoglobin level which was found to be 55%. Read More

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http://dx.doi.org/10.1007/s12024-018-9990-xDOI Listing
May 2018
1 Read

Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity.

Dalton Trans 2018 Oct;47(40):14241-14253

School of Chemistry, Main Building, Cardiff University, Cardiff CF10 3AT, UK.

A systematic study of the cellular uptake of emissive complexes as a function of their lipophilicity is presented. Here a series of amphiphilic rhenium fac-tricarbonyl bisimine complexes bearing axial substituted imidazole or thiazole ligands, [Re(bpy)(CO)3(ImCnHm)]+ {n = 1 m = 3 (1+), n = 4 m = 9 (2+), n = 8 m = 17 (3+), n = 12 m = 25 (4+), n = 16 m = 33 (5+), n = 2 m = 3 (6+); bpy = 2,2'-bipyridine, Im = imidazole} and [Re(bpy)(CO)3(L)]+ {L = 1-mesitylimidazole, ImMes (7+), 4,5-dimethylthiazole, dmt (8+) and 4-methyl-5-thiazole-ethanol, mte (9+)} is reported. The X-ray crystal structures of 2+, 8+ and 9+ confirm the geometry and expected distribution of ligands and indicated that the plane of the imidazole/thiazole ring is approximately parallel to the long axis of the bipy ligand. Read More

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http://dx.doi.org/10.1039/c8dt00669eDOI Listing
October 2018

Microbial fuel cell-based biosensor for toxic carbon monoxide monitoring.

Talanta 2018 Aug 27;186:368-371. Epub 2018 Apr 27.

Department of Environmental Engineering, Technical University of Denmark, DK-2800 Lyngby, Denmark. Electronic address:

This study presents an innovative microbial fuel cell-based biosensor for carbon monoxide (CO) monitoring. The hypothesis for the function of the biosensor is that CO inhibits bacterial activity in the anode and thereby reduces electricity production. A mature electrochemically active biofilm on the anode was exposed to CO gas at varied concentrations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183044
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http://dx.doi.org/10.1016/j.talanta.2018.04.084DOI Listing
August 2018
11 Reads

The effect of meteorological conditions and air pollution on the occurrence of type A and B acute aortic dissections.

Int J Biometeorol 2018 Sep 19;62(9):1607-1613. Epub 2018 May 19.

Department of Emergency, West China Hospital, Sichuan University, Number 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.

To explore the association of weather conditions and air pollutants with incidence risk of acute aortic dissection (AAD), we included patients who consecutively admitted to the emergency units of our hospital for AAD between Dec. 1, 2013, and Apr. 30, 2017. Read More

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http://dx.doi.org/10.1007/s00484-018-1560-0DOI Listing
September 2018
2 Reads

Accidental Carbon Monoxide Poisoning While Driving: A Case Report With Review of the Literature.

Am J Forensic Med Pathol 2018 Sep;39(3):270-272

Department of Pathology, University of Michigan, Ann Arbor, MI.

Carbon monoxide (CO) is the cause of a significant percentage of fatal poisonings in many countries. It is known that fatalities resulting from CO poisoning are underreported and/or misclassified. Carbon monoxide exposure while driving can occur due to faulty exhaust systems, defective ventilation systems, emission from other vehicles, and even cigarette smoking. Read More

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http://Insights.ovid.com/crossref?an=00000433-900000000-9921
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http://dx.doi.org/10.1097/PAF.0000000000000400DOI Listing
September 2018
9 Reads

Bubble coalescence suppression driven carbon monoxide (CO)-water mass transfer increase by electrolyte addition in a hollow fiber membrane bioreactor (HFMBR) for microbial CO conversion to ethanol.

Bioresour Technol 2018 Sep 4;263:375-384. Epub 2018 May 4.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea. Electronic address:

This study investigated the effects of electrolytes (CaCl, KHPO, MgSO, NaCl, and NHCl) on CO mass transfer and ethanol production in a HFMBR. The hollow fiber membranes (HFM) were found to generate tiny gas bubbles; the bubble coalescence was significantly suppressed in electrolyte solution. The volumetric gas-liquid mass transfer coefficients (ka) increased up to 414% compared to the control. Read More

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http://dx.doi.org/10.1016/j.biortech.2018.05.012DOI Listing
September 2018
7 Reads

Carboxyhemoglobin: a primer for clinicians.

Authors:
Neil B Hampson

Undersea Hyperb Med 2018 Mar-Apr;45(2):165-171

Center for Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington.

One of carbon monoxide's several mechanisms of toxicity is binding with circulating hemoglobin to form carboxyhemoglobin, resulting in a functional anemia. While patients with carbon monoxide poisoning are often said to be "cherry-red," such discoloration is rarely seen. Carboxyhemoglobin levels cannot be measured with conventional pulse oximetry, can be approximated with pulse CO-oximetry, and are most accurately measured with a laboratory CO-oximeter. Read More

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Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine.

Int J Mol Sci 2018 Apr 29;19(5). Epub 2018 Apr 29.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", School of Medicine, via Luigi de Crecchio 7, 80138 Naples, Italy.

The non-proteinogenic amino acid lanthionine is a byproduct of hydrogen sulfide biosynthesis: the third endogenous vasodilator gas, after nitric oxide and carbon monoxide. While hydrogen sulfide is decreased in uremic patients on hemodialysis, lanthionine is increased and has been proposed as a new uremic toxin, since it is able to impair hydrogen sulfide production in hepatoma cells. To characterize lanthionine as a uremic toxin, we explored its effects during the early development of the zebrafish (), a widely used model to study the organ and tissue alterations induced by xenobiotics. Read More

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http://www.mdpi.com/1422-0067/19/5/1323
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http://dx.doi.org/10.3390/ijms19051323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983689PMC
April 2018
8 Reads

Influence of Air Pollution on Hospital Admissions in Adult Asthma in Northeast China.

Chin Med J (Engl) 2018 May;131(9):1030-1033

Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, Jilin 130021, China.

Background: Asthma is a common chronic respiratory disease and is related to air pollution exposure. However, only a few studies have concentrated on the association between air pollution and adult asthma. Moreover, the results of these studies are controversial. Read More

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http://dx.doi.org/10.4103/0366-6999.230735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937309PMC
May 2018
2 Reads

Overcoming safety challenges in CO therapy - Extracorporeal CO delivery under precise feedback control of systemic carboxyhemoglobin levels.

J Control Release 2018 Jun 12;279:336-344. Epub 2018 Apr 12.

Institute for Pharmacy and Food Chemistry, University of Würzburg, Germany. Electronic address:

Carbon monoxide (CO) has demonstrated therapeutic potential in multiple inflammatory conditions including intensive care applications such as organ transplantation or sepsis. Approaches to translate these findings into future therapies, however, have been challenged by multiple hurdles including handling and toxicity issues associated with systemic CO delivery. Here, we describe a membrane-controlled Extracorporeal Carbon Monoxide Release System (ECCORS) for easy implementation into Extracorporeal Membrane Oxygenation (ECMO) setups, which are being used to treat cardiac and respiratory diseases in various intensive care applications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183019
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http://dx.doi.org/10.1016/j.jconrel.2018.04.017DOI Listing
June 2018
15 Reads

Epidemiological Study of Carbon Monoxide Deaths in Scotland 2007-2016.

J Forensic Sci 2018 Nov 12;63(6):1776-1782. Epub 2018 Apr 12.

Forensic Medicine & Science, School of Medicine, Dentistry & Nursing, University of Glasgow, University Place, Glasgow, G12 8QQ, U.K.

Carbon monoxide (CO) intoxications are quite frequent in forensic toxicology. Using a sample of 209 CO-positive deaths in Scotland from 2007 to 2016, this study provides ranges of percentage CO saturations (%COHb) according to the CO source and examines any correlation with age, gender, alcohol, and preexisting disease. It also reports the full toxicological findings, including drug concentrations, in CO-positive cases. Read More

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http://doi.wiley.com/10.1111/1556-4029.13790
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http://dx.doi.org/10.1111/1556-4029.13790DOI Listing
November 2018
4 Reads

A Fatal Case of Gas Intoxication in Silage Pit.

J Forensic Sci 2018 Nov 10;63(6):1904-1907. Epub 2018 Apr 10.

Department of Forensic Medicine and Medical Law, University Hospital Olomouc, Olomouc, CZ-779 00, Czech Republic.

Fatalities due to gas intoxication are rare in routine forensic casework. The most common gas is carbon monoxide, with other gases (ammonia, methane, propane and butane, carbon dioxide, hydrogen sulfide) encountered only very rarely. In this report, we describe the accidental death of two maintenance workers who were found in the silage pit at a biogas plant. Read More

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http://dx.doi.org/10.1111/1556-4029.13791DOI Listing
November 2018
2 Reads

Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin.

Toxicol In Vitro 2018 Aug 23;50:201-209. Epub 2018 Mar 23.

Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Inhaled carbon monoxide (CO) gas is highly toxic, but the human body produces low levels of CO for vasoregulation and other purposes. Given the established protective roles of low concentrations of CO gas against a panel of pathological insults, CO-releasing molecules (CORMs) have been developed and examined in disease models both in vitro and in vivo. Among CORMs, CORM-3 [Ru(CO)Cl(glycinate)], a ruthenium carbonyl compound, has been extensively studied since it is water-soluble and is suitable for in vivo application. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.03.010DOI Listing
August 2018
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Co-culture-based biological carbon monoxide conversion by Citrobacter amalonaticus Y19 and Sporomusa ovata via a reducing-equivalent transfer mediator.

Bioresour Technol 2018 Jul 2;259:128-135. Epub 2018 Mar 2.

School of Chemical and Biomolecular Engineering, Pusan National University, 63 Busandeahak-ro, Geumjeong-Gu, Busan 46241, Republic of Korea. Electronic address:

The biological conversion of carbon monoxide (CO) has been highlighted for the development of a C1 gas biorefinery process. Despite this, the toxicity and low reducing equivalent of CO uptake make biological conversion difficult. The use of synthetic co-cultures is an alternative way of enhancing the performance of CO bioconversion. Read More

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http://dx.doi.org/10.1016/j.biortech.2018.02.129DOI Listing
July 2018
9 Reads

Acute carbon monoxide toxicity in a paediatric cohort: analysis of 10 boys poisoned during a scuba diving lesson.

Clin Toxicol (Phila) 2018 Sep 8;56(9):856-859. Epub 2018 Mar 8.

a Paediatric Emergency Department , Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust , Manchester , UK.

Background: Recent public health strategies have contributed towards a significant reduction in the incidence of carbon monoxide (CO) poisonings. When events do occur, symptoms can vary dramatically depending on the carboxyhaemoglobin level and individual factors. Most reports to date focus on individual cases or larger retrospective reviews of diverse cohorts. Read More

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http://dx.doi.org/10.1080/15563650.2018.1444175DOI Listing
September 2018
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Effects of volatile organic compounds and carbon monoxide mixtures on learning and memory, oxidative stress, and monoamine neurotransmitters in the brains of mice.

Toxicol Ind Health 2018 Mar 5;34(3):178-187. Epub 2018 Mar 5.

4 College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.

In this study, we investigated the effect of inhaled mixtures of volatile organic compounds (VOCs) and carbon monoxide (CO) on neuroethology. Fifty 6-week-old male Kunming mice were exposed in five similar static chambers; zero (control) and four different doses of VOC and CO mixtures (G1-G4) for 10 consecutive days and 2 h/day. The compounds and concentrations were as follows: formaldehyde, benzene, toluene, xylene, and CO as 0. Read More

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http://dx.doi.org/10.1177/0748233717747504DOI Listing
March 2018
24 Reads

Emergency department management of smoke inhalation injury in adults [digest].

Emerg Med Pract 2018 Mar 1;20(3 Suppl Points & Pearls):1-2. Epub 2018 Mar 1.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Smoke inhalation injury portends increased morbidity and mortality in fire-exposed patients. Upper airway thermal burns, inflammation from lower airway irritants, and systemic effects of carbon monoxide and cyanide can contribute to injury. A standardized diagnostic protocol for inhalation injury is lacking, and management remains mostly supportive. Read More

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March 2018
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Emergency department management of smoke inhalation injury in adults.

Emerg Med Pract 2018 Mar 1;20(3):1-24. Epub 2018 Mar 1.

Clinical Assistant Professor, Residency Assistant Program Director, Department of Emergency Medicine, Stony Brook School of Medicine, Stony Brook, NY.

Smoke inhalation injury portends increased morbidity and mortality in fire-exposed patients. Upper airway thermal burns, inflammation from lower airway irritants, and systemic effects of carbon monoxide and cyanide can contribute to injury. A standardized diagnostic protocol for inhalation injury is lacking, and management remains mostly supportive. Read More

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Highs and lows of hyperoxia: physiological, performance, and clinical aspects.

Am J Physiol Regul Integr Comp Physiol 2018 Jul 28;315(1):R1-R27. Epub 2018 Feb 28.

Centre for Heart, Lung, and Vascular Health, University of British Columbia , Kelowna, British Columbia , Canada.

Molecular oxygen (O) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content ([Formula: see text]), it also causes vasoconstriction and hence reduces O delivery in various vascular beds, including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of hypoxic stress. Read More

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https://www.physiology.org/doi/10.1152/ajpregu.00165.2017
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http://dx.doi.org/10.1152/ajpregu.00165.2017DOI Listing
July 2018
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Carbon Monoxide and Cyanide Poisoning in the Burned Pregnant Patient: An Indication for Hyperbaric Oxygen Therapy.

Ann Plast Surg 2018 Mar;80(3 Suppl 2):S106-S112

Carbon monoxide (CO) is a small molecule poison released as a product of incomplete combustion. Carbon monoxide binds hemoglobin, reducing oxygen delivery. This effect is exacerbated in the burned pregnant patient by fetal hemoglobin that binds CO 2. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825244PMC
March 2018
10 Reads

Carbon monoxide (CO) modulates hydrogen peroxide (HO)-mediated cellular dysfunction by targeting mitochondria in rabbit lens epithelial cells.

Exp Eye Res 2018 04 31;169:68-78. Epub 2018 Jan 31.

Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address:

Mitochondrial components are of great importance for the maintenance of lens transparency. In our previous work, we confirmed that carbon monoxide (CO) can protect human and rabbit lens epithelial cells (LECs) from hydrogen peroxide (HO)-mediated apoptosis, while the mechanism remains undefined. Because CO can bind to mitochondrial cytochrome c oxidase (COX), we evaluated the effect of CO on the regulation of mitochondrial biogenesis and function in HO-treated rabbit LECs. Read More

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http://dx.doi.org/10.1016/j.exer.2018.01.023DOI Listing
April 2018
8 Reads

Implications of Combined Exposure to Household Air Pollution and HIV on Neurocognition in Children.

Int J Environ Res Public Health 2018 01 20;15(1). Epub 2018 Jan 20.

Department of Global Health, University of Washington School of Public Health, Seattle, WA 98104, USA.

Air pollution exposure and HIV infection can each cause neurocognitive insult in children. The purpose of this study was to test whether children with combined high air pollution exposure and perinatal HIV infection have even greater risk of neurocognitive impairment. This was a cross-sectional study of HIV-uninfected unexposed (HUU) and HIV-infected children and their caregivers in Nairobi, Kenya. Read More

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http://dx.doi.org/10.3390/ijerph15010163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800262PMC
January 2018
8 Reads

The partial pressure of carbon monoxide in human tissues calculated using a parallel capillary-tissue cylinder model.

Authors:
Ronald F Coburn

J Appl Physiol (1985) 2018 Mar 4;124(3):761-768. Epub 2018 Jan 4.

Department of Physiology, the Perelman School of Medicine, the University of Pennsylvania , Philadelphia, Pennsylvania.

Tissue P values have not been previously estimated under conditions where the blood carboxyhemoglobin % saturation ([COHb]) is at a normal level or increased. Tissue P values are not known for conditions when [COHb] is increased during CO therapy or during CO poisoning. Using a modified Krogh parallel capillary-tissue model, mean tissue P was calculated for when [COHb] was 1, 5, 10, and 15% saturation, relevant to CO therapy, and 20, 30, and 40% saturation, relevant to CO poisoning. Read More

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http://dx.doi.org/10.1152/japplphysiol.00833.2017DOI Listing
March 2018
2 Reads