Nitric Oxide 2021 02 15;107:31-45. Epub 2020 Dec 15.
Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Member of the German Center for Lung Research (DZL), Parkstrasse 1, 60231, Bad Nauheim, Germany; Department of Internal Medicine (Pulmonology), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, Aulweg 123, 35392, Giessen, Germany; CardioPulmonary Institute, Justus Liebig University Giessen, Klinikstrasse 33, Giessen, Germany. Electronic address:
Along with nitric oxide (NO), the gasotransmitters carbon monoxide (CO) and hydrogen sulfide (HS) are emerging as potentially important players in newborn physiology, as mediators of newborn disease, and as new therapeutic modalities. Several recent studies have addressed HS in particular in animal models of bronchopulmonary dysplasia (BPD), a common complication of preterm birth where oxygen toxicity stunts lung development. In those studies, exogenous HS attenuated the impact of oxygen toxicity on lung development, and two HS-generating enzymes were documented to affect pulmonary vascular development. Read More