1,136 results match your criteria Toxicity Carbamazepine


Embryotoxicity of ozonated diclofenac, carbamazepine, and oxazepam in zebrafish (Danio rerio).

Chemosphere 2019 Mar 7;225:191-199. Epub 2019 Mar 7.

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Pharmaceutical residues are polluting the surface water environments worldwide. Sewage and wastewater treatment, therefore, needs to be improved in order to remove pharmaceutical residues from the effluent. One such treatment improvement is effluent ozonation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.03.034DOI Listing

Ecotoxicological characterization of the antiepileptic drug carbamazepine using eight aquatic species: baseline study for future higher tier tests.

J Environ Sci Health A Tox Hazard Subst Environ Eng 2019 Feb 21:1-11. Epub 2019 Feb 21.

a Department Aquatic Ecotoxicology, Faculty of Biological Sciences , Goethe University Frankfurt am Main , Frankfurt am Main , Germany.

Ecotoxicological effects of the antiepileptic drug carbamazepine (CBZ) were investigated in one primary producer (Desmodesmus subspicatus) and seven invertebrate species (Daphnia magna, Daphnia pulex, Ceriodaphnia dubia, Gammarus fossarum, Potamopyrgus antipodarum, Lumbriculus variegatus and Chironomus riparius) using OECD and US EPA guidelines for chronic toxicity testing. The present data set was used to conduct a hazard assessment for CBZ including confirmatory data. While most of our results were in accordance with previous studies, published effect data for C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10934529.2018.1562819DOI Listing
February 2019

Effect of psychiatric drugs on Daphnia magna oxylipin profiles.

Sci Total Environ 2018 Dec 11;644:1101-1109. Epub 2018 Jul 11.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, Barcelona 08034, Catalonia, Spain. Electronic address:

Neuro-active pharmaceuticals have been reported to act as endocrine disruptors enhancing reproduction in the model crustacean Daphnia manga at environmental concentrations of ng/L. Oxylipins and more specifically eicosanoids, which are lipid mediators formed from polyunsaturated fatty acids (PUFAs), are known to regulate reproduction together with other physiological processes in insects. In D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.06.333DOI Listing
December 2018

Behavioral profile alterations in zebrafish larvae exposed to environmentally relevant concentrations of eight priority pharmaceuticals.

Sci Total Environ 2019 May 24;664:89-98. Epub 2019 Jan 24.

Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany. Electronic address:

Although the effects of pharmaceuticals on aquatic organisms have been widely investigated during the last decades, toxic effects, especially delayed toxicity, during the developmental stage at environmental relevant concentrations were rarely known. In this study, a sensitive assay based on behavioral alterations was used for studying the delayed toxicity during the developmental stage on zebrafish embryos. Eight pharmaceuticals that were frequently detected with concentrations ranging from ng/l to μg/l were screened for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.01.300DOI Listing
May 2019
1 Read

Oxidative removal of carbamazepine by peroxymonosulfate (PMS) combined to ionizing radiation: Degradation, mineralization and biological toxicity.

Sci Total Environ 2019 Mar 21;658:1367-1374. Epub 2018 Dec 21.

Collaborative Innovation Center for Advanced Nuclear Energy Technology, INET, Tsinghua University, Beijing 100084, PR China; State Key Joint Laboratory of Environment Simulation and Pollution Control, Tsinghua University, Beijing 100084, PR China; Beijing Key Laboratory of Radioactive Wastes Treatment, Tsinghua University, Beijing 100084, PR China. Electronic address:

Carbamazepine is one of pharmaceutical and personal care products (PPCPs) and has been widely used to treat depression and seizures, and it cannot be effectively removed during the conventional wastewater treatment processes. In this study, three processes were used for the carbamazepine degradation, including single radiation, radiation in the presence of peroxymonosulfate (PMS) and radiation followed by PMS oxidation. The results show that radiation in the presence of PMS could enhance the degradation and mineralization of carbamazepine, decreasing the absorbed dose required for completely degrading carbamazepine from 800 Gy to 300 Gy, no matter what the molar ratio of PMS to carbamazepine was. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697183518
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2018.12.304DOI Listing
March 2019
5 Reads

Transformation of endocrine disrupting chemicals, pharmaceutical and personal care products during drinking water disinfection.

Sci Total Environ 2019 Mar 11;657:1480-1490. Epub 2018 Dec 11.

Australian Rivers Institute, School of Environment and Science, Griffith University, Southport, Qld 4222, Australia; The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), Woolloongabba, Qld 4102, Australia; UFZ - Helmholtz Centre for Environmental Research, Cell Toxicology, 04318 Leipzig, Germany.

Pharmaceuticals and personal care products (PPCPs) and endocrine disrupting compounds (EDCs) are frequently detected in drinking water sources. This raises concerns about the formation of potentially more toxic transformation products (TPs) after drinking water disinfection. This study applied a combination of computational and experimental methods to investigate the biological activity of eight EDCs and PPCPs commonly detected in source waters (acetaminophen, bisphenol A, carbamazepine, estrone, 17α-ethinylestradiol, gemfibrozil, naproxen and triclosan) before and after disinfection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.12.106DOI Listing
March 2019
4.099 Impact Factor

Degradation of carbamazepine by vacuum-UV oxidation process: Kinetics modeling and energy efficiency.

J Hazard Mater 2019 Apr 15;368:178-185. Epub 2019 Jan 15.

Department of Water Engineering and Science, College of Civil Engineering, Hunan University, Changsha, Hunan, 410082, China.

Vaccum-ultraviolet (VUV) is effective for elimination of organic contaminants in aqueous environment and degradation of carbamazepine (CBZ) by VUV irradiation was systematically investigated in this study. A dynamic kinetic model was developed to simulate the destruction of CBZ that is mainly initiated by hydroxyl radicals (HO). The second-order rate constant of the reaction between CBZ and HO was determined to be 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2019.01.043DOI Listing
April 2019
1 Read

Carbamazepine disrupts molting hormone signaling and inhibits molting and growth of Eriocheir sinensis at environmentally relevant concentrations.

Aquat Toxicol 2019 Mar 14;208:138-145. Epub 2019 Jan 14.

Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32611, USA.

Carbamazepine (CBZ), one of the most frequently detected pharmaceutical compounds in aquatic environments, has recently been shown to cause chronic toxicity and endocrine disruption in a variety of non-target aquatic organisms. However, neither the effects nor the specific mechanism of CBZ action on the molting of crustaceans is well understood. The aim of this study was to investigate the effects of CBZ on the molting and growth of the Chinese mitten crab Eriocheir sinensis, a native and economically important species in China, and to elucidate the specific mechanisms through which molt inhibition occurs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.01.010DOI Listing
March 2019
1 Read

Occurence and Prioritization of Pharmaceutical Active Compounds in Domestic/Municipal Wastewater Treatment Plants.

Bull Environ Contam Toxicol 2019 Feb 21;102(2):252-258. Epub 2019 Jan 21.

Institut für Energie-und Umwelttechnik e.V. (IUTA, Institute of Energy and Environmental Technology), Bliersheimer Str. 58-60, 47229, Duisburg, Germany.

In this study, pharmaceutically active compounds (PhACs) were analyzed in the influent and effluent of a domestic wastewater treatment plant in Turkey and a municipal wastewater treatment plant in Germany and the toxicity of these wastewaters were estimated using a toxic unit (TU) approach. A total of 21 and 32 PhACs were detected in the domestic wastewater and the municipal wastewater, respectively. The TUs estimated for PhACs in municipal wastewater were higher than the TUs estimated for PhACs present in domestic wastewater. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00128-019-02550-zDOI Listing
February 2019
2 Reads

Acute and Chronic Toxicity of Carbamazepine on the Release of Chitobiase, Molting, and Reproduction in .

Int J Environ Res Public Health 2019 Jan 13;16(2). Epub 2019 Jan 13.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China.

As one of the most frequently detected pharmaceutical compounds in aquatic environments, carbamazepine (CBZ) has recently been shown to cause acute and chronic toxicity in a variety of non-target aquatic organisms. However, little is known about the ecotoxicological effects it has on the molting and reproduction of crustaceans. The aim of the present work was to evaluate the acute and chronic toxic responses to CBZ in the crustacean . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16020209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351914PMC
January 2019
1 Read

Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio).

Environ Toxicol Pharmacol 2019 Feb 21;66:96-103. Epub 2018 Dec 21.

Laboratory of Environmental Toxicology, Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón intersección Paseo Tollocan s/n. Col. Residencial Colón, 50120, Toluca, Estado de México, Mexico.

The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.etap.2018.12.017DOI Listing
February 2019
2 Reads

Effect of electrolytes on the simultaneous electrochemical oxidation of sulfamethoxazole, propranolol and carbamazepine: behaviors, by-products and acute toxicity.

Environ Sci Pollut Res Int 2019 Jan 11. Epub 2019 Jan 11.

Mexican Institute of Water Technology (IMTA), Paseo Cuauhnahuac 8532, Progreso, 62550, Jiutepec, Morelos, Mexico.

In this work, the effect of supporting electrolytes on the simultaneous electrochemical oxidation of the pharmaceuticals sulfamethoxazole (SMX), propranolol (PRO), and carbamazepine (CBZ) in aqueous solutions has been studied. Based on the identified by-products, the degradation mechanisms were proposed and the acute toxicity was evaluated for each electrolyte. Assays were carried out in batch mode in a 2 L undivided reactor using a niobium coated with boron-doped diamond (Nb/BDD) mesh anode and Ti cathode at 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-018-4020-9DOI Listing
January 2019
2 Reads

First aid interventions by laypeople for acute oral poisoning.

Cochrane Database Syst Rev 2018 12 19;12:CD013230. Epub 2018 Dec 19.

Centre for Evidence-Based Practice (CEBaP), Belgian Red Cross, Motstraat 42, Mechelen, Belgium, 2800.

Background: Oral poisoning is a major cause of mortality and disability worldwide, with estimates of over 100,000 deaths due to unintentional poisoning each year and an overrepresentation of children below five years of age. Any effective intervention that laypeople can apply to limit or delay uptake or to evacuate, dilute or neutralize the poison before professional help arrives may limit toxicity and save lives.

Objectives: To assess the effects of pre-hospital interventions (alone or in combination) for treating acute oral poisoning, available to and feasible for laypeople before the arrival of professional help. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD013230
Publisher Site
http://dx.doi.org/10.1002/14651858.CD013230DOI Listing
December 2018
8 Reads

Pharmaceuticals as chemical markers of wastewater contamination in the vulnerable area of the Ebro Delta (Spain).

Sci Total Environ 2019 Feb 22;652:952-963. Epub 2018 Oct 22.

Catalan Institute for Water Research (ICRA), C/Emili Grahit 101, 17003 Girona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluis Company 23, 08010 Barcelona, Spain.

This study evaluated the occurrence and distribution of 81 pharmaceutically active compounds (PhACs) in the vulnerable area of the Ebro Delta region (Catalonia, Spain), to assess the environmental impact of wastewater treatment plants discharge to coastal environments. The occurrence of PhACs was followed along the wastewater-recipient water-sediment chain until they reach estuaries and the Mediterranean Sea. Water and sediment samples were collected in an integrated way at different sampling points covering three different seasons in reaches of the Ebro River located upstream and downstream from wastewater treatment plants (WWTPs), surrounding channels, estuaries, and the associated receiving seawater. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697183418
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2018.10.290DOI Listing
February 2019
4 Reads

Environmentally-relevant mixture of pharmaceutical drugs stimulates sex-steroid hormone production and modulates the expression of candidate genes in the ovary of juvenile female rainbow trout.

Aquat Toxicol 2018 Dec 13;205:89-99. Epub 2018 Oct 13.

University of Namur, Institute of Life, Earth & Environment, Research Unit in Environmental and Evolutionary Biology, 61 rue de Bruxelles, B-5000 Namur, Belgium. Electronic address:

Because of their intrinsic biological activity and ubiquitous environmental occurrence, human pharmaceutical compounds have received increasing attention from health and environmental agencies. In the present study, all-female juvenile rainbow trout (Oncorhynchus mykiss) were exposed to environmentally-realistic concentrations of a mixture of nonsteroidal pharmaceuticals for 42 days, and the effects on plasma levels of sex-steroids and the expression of genes encoding key proteins involved in ovarian development were assessed. Paracetamol, carbamazepine, diclofenac, irbesartan and naproxen were selected, as these have been detected in the Meuse River in Belgium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2018.10.006DOI Listing
December 2018
3 Reads

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals.

Free Radic Biol Med 2018 Dec 17;129:559-568. Epub 2018 Oct 17.

Centro de Química Estrutural, Instituto Superior Técnico, ULisboa, 1049-001 Lisboa, Portugal. Electronic address:

Carbamazepine (CBZ) is one of the most widely used antiepileptic drugs by both adults and children. Despite its widespread use, CBZ is associated with central nervous system toxicity and severe hypersensitivity reactions, which raise concerns about its chronic use. While the precise mechanisms of CBZ-induced adverse events are still unclear, metabolic activation to the epoxide (CBZ-EP) has been thought to play a significant role. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.408DOI Listing
December 2018
2 Reads

Monitoring transformation product formation in the drinking water treatments rapid sand filtration and ozonation.

Chemosphere 2019 Jan 26;214:801-811. Epub 2018 Sep 26.

KWR Watercycle Research Institute, P.O. Box 1072, 3430 BB Nieuwegein, the Netherlands.

Transformation products (TPs) can be formed from organic micropollutants in the water cycle through both biological and technological processes. Despite the TPs' potentially altered toxicity compared to their parent compounds, transformation processes are not routinely monitored, and in particular those induced by drinking water treatment remain elusive. This lack of information is mainly due to the technical challenges in analyzing TPs, which are often unknown compounds occurring in low concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.09.140DOI Listing
January 2019
2 Reads

In situ growth of Ag-SnO quantum dots on silver phosphate for photocatalytic degradation of carbamazepine: Performance, mechanism and intermediates toxicity assessment.

J Colloid Interface Sci 2019 Jan 12;534:270-278. Epub 2018 Sep 12.

Brook Byers Institute for Sustainable Systems and School of Civil and Environmental Engineering, Georgia Institute of Technology, 828 West Peachtree Street, Atlanta, GA 30332, United States.

The occurrence of carbamazepine (CBZ) in environments poses a potential risk to aquatic life and exhibits growth inhibition of human embryonic cells. In this work, for the first time a series of Ag-SnO quantum dots (QDs)/silver phosphate (AgSn/AgP) composites were synthesized and used as photocatalysts for CBZ degradation. The obtained AgSn/AgP composites showed superior photodegradation efficiency for CBZ removal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2018.09.039DOI Listing
January 2019
14 Reads

Environmentally relevant concentrations of carbamazepine induce liver histopathological changes and a gender-specific response in hepatic proteome of Chinese rare minnows (Gobiocypris rarus).

Environ Pollut 2018 Dec 5;243(Pt A):480-491. Epub 2018 Sep 5.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

To assess hepatotoxicity and to determine the underlying mechanisms of carbamazepine (CBZ) toxicity in fish, histopathology and the liver proteome were examined after Chinese rare minnow (Gobiocypris rarus) were exposed to 1, 10, and 100 μg/L CBZ for 28 days. Histopathological changes included disruption of spatial structure, pyknotic nuclei, cellular vacuolization and deformation of cell nuclei, in addition to marked swelling of hepatocytes in all treatment groups. Protein analysis revealed that there were gender-specific responses in rare minnow following exposure, and there were 47 proteins in females and 22 proteins in males identified as differentially abundant following CBZ treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2018.09.009DOI Listing
December 2018
2 Reads

Multifunctional carbamazepine loaded nanostructured lipid carrier (NLC) formulation.

Int J Pharm 2018 Oct 1;550(1-2):359-371. Epub 2018 Sep 1.

Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, P.O. Box 2014, Skaka, Saudi Arabia.

Carbamazepine is a valuable pharmacological agent prescribed in treatment of epilepsy and trigeminal neuralgia. Poor bioavailability, successive dose adjustments and reported long term toxic effects are the main hurdles associated with carbamazepine oral administration. Bees wax containing NLC formulations were developed using high shear homogenization/sonication technique to overcome drug limitations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.08.062DOI Listing
October 2018
5 Reads
3.650 Impact Factor

Evaluation of Daphnia magna metabolic responses to organic contaminant exposure with and without dissolved organic matter using H nuclear magnetic resonance (NMR)-based metabolomics.

Ecotoxicol Environ Saf 2018 Nov 14;164:189-200. Epub 2018 Aug 14.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada M5S 3H6; Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada M1C 1A4. Electronic address:

Previous studies have shown that contaminant toxicity to target organisms is altered by the presence of dissolved organic matter (DOM). Contaminants can bind to DOM and this may alter the bioavailability and subsequent toxicity of the contaminants. However, molecular-level techniques are needed to more closely evaluate the impact of DOM on the sub-lethal biochemical responses to emerging contaminants. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01476513183073
Publisher Site
http://dx.doi.org/10.1016/j.ecoenv.2018.08.006DOI Listing
November 2018
8 Reads

Influence of Inflammation on the Pharmacokinetics of Perampanel.

Ther Drug Monit 2018 12;40(6):725-729

Department of Clinical Research, National Epilepsy Center, NHO, Shizuoka Institute of Epilepsy and Neurological Disorders.

Background: It is well-known that the pharmacokinetics of various drugs are influenced by inflammation. This study evaluated the relationship between C-reactive protein (CRP; an inflammation marker) and the pharmacokinetics of perampanel.

Methods: Among 111 patients who underwent measurement of both CRP and perampanel, 23 patients had a serum CRP level exceeding 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000556DOI Listing
December 2018
16 Reads

Sublethal and chronic effects of reclaimed water on aquatic organisms. Looking for relationships between physico-chemical characterisation and toxic effects.

Sci Total Environ 2018 Nov 18;640-641:1537-1547. Epub 2018 Jun 18.

Laboratory for Ecotoxicology, Department of Environment, INIA, Crta. La Coruña km 7, 28040 Madrid, Spain.

The use of reclaimed water for irrigation and aquaculture purposes is generally considered a reliable alternative for sustainable water management in regions with water scarcity. Many organic compounds, generally called compounds of emerging concern (CECs), have been detected in reclaimed water, which implies continuous exposure for aquatic organisms. To date no quality criteria have been proposed for this group of compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.05.349DOI Listing
November 2018
4 Reads

Toxic effects of human pharmaceuticals to Folsomia candida - A multigeneration approach.

Sci Total Environ 2018 Jun 12;625:1225-1233. Epub 2018 Jan 12.

Department of Biology, CESAM - Centre for Environmental and Marine Studies, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2017.12.319DOI Listing
June 2018
2 Reads

Attenuation of pharmaceuticals, nutrients and toxicity in a rural sewage lagoon system integrated with a subsurface filtration technology.

Chemosphere 2018 Oct 19;209:767-775. Epub 2018 Jun 19.

Department of Environment and Geography, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; Escuela de Química, Instituto Tecnológico de Costa Rica, Cartago, 159-7050, Costa Rica; Richardson College for the Environment, Department of Environmental Studies and Sciences and Department of Chemistry, The University of Winnipeg, Winnipeg, MB, R3B 2E9, Canada. Electronic address:

Although many studies have addressed the ability of subsurface filtration systems to remove emerging contaminants from wastewater at micro- and mesocosm-scale, little is known about their performance on full-scale wastewater treatment facilities. To understand better how effective these systems can be for municipal wastewater polishing, we assessed the ability of a full-scale lagoon-subsurface filter system located in Dunnottar, Manitoba, Canada, to attenuate regulatory wastewater parameters, nutrients, pharmaceuticals, and toxicity over the course of the discharge periods in 2015 and 2016 (June-October). Pharmaceuticals included β-blockers, anticonvulsant drugs, and macrolide and sulfonamide antibiotics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.06.119DOI Listing
October 2018
3 Reads

Effects of nanoplastics on Mytilus galloprovincialis after individual and combined exposure with carbamazepine.

Sci Total Environ 2018 Dec 27;643:775-784. Epub 2018 Jun 27.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Plastic pollution is a worldwide problem, highlighted by the fact that plastic materials degrade into nano-size particles (<100 nm), potentially becoming more bioavailable as well as a source of entry of other contaminants into organisms. The present study aimed to assess the effects of polystyrene nanoplastics (PS), individually or combined with carbamazepine (Cbz), on the Mediterranean mussel, Mytilus galloprovincialis. For this purpose, mussels were exposed for 96 h to a concentration range of PS (from 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.06.257DOI Listing
December 2018
7 Reads

A synoptic survey of select wastewater-tracer compounds and the pesticide imidacloprid in Florida's ambient freshwaters.

Environ Monit Assess 2018 Jun 27;190(7):435. Epub 2018 Jun 27.

Florida Department of Environmental Protection, Division of Environmental Assessment and Restoration, 2600 Blair Stone Rd., Tallahassee, FL, 32399-2400, USA.

Current wastewater treatment technologies do not remove many unregulated hydrophilic compounds, and there is growing interest that low levels of these compounds, referred to as emerging contaminants, may impact human health and the environment. A probabilistic-designed monitoring network was employed to infer the extent of Florida's ambient freshwaters containing the wastewater (Includes reuse water, septic systems leachate, and wastewater treatment effluent.) indicators sucralose, acetaminophen, carbamazepine, and primidone and those containing the widely used pesticide imidacloprid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10661-018-6782-4DOI Listing
June 2018
4 Reads

Sublethal metabolic responses to contaminant mixture toxicity in Daphnia magna.

Environ Toxicol Chem 2018 09 30;37(9):2448-2457. Epub 2018 Jul 30.

Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto, Toronto, Ontario, Canada.

Anthropogenic activity is increasing the presence of contaminants that enter waterways through wastewater effluent and urban and/or agricultural runoff, generally in complex mixtures. Depending on the mode of action of the individual contaminant within the mixture, toxicity can occur due to contaminants having similar or dissimilar modes of action. However, it is unknown how the metabolome responds to sublethal contaminant mixtures in the keystone genus Daphnia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/etc.4208DOI Listing
September 2018

Brivaracetam-induced elevation of carbamazepine epoxide levels: A post-hoc analysis from the clinical development program.

Epilepsy Res 2018 09 4;145:55-62. Epub 2018 Jun 4.

UCB Pharma, Raleigh, NC, USA.

To assess the association, if any, between brivaracetam (BRV)-induced elevated carbamazepine-10,11-epoxide (CBZ-E) and toxicity and efficacy in patients with epilepsy. Data were pooled from three double-blind, placebo-controlled, Phase III studies of adjunctive BRV in adults with uncontrolled focal seizures (N01252/NCT00490035, N01253/NCT00464269, N01358/NCT01261325). Treatment-emergent adverse events (TEAEs) of interest (ataxia, diplopia, dizziness, nystagmus, somnolence, accidental overdose or poisoning, and toxicity), discontinuations due to TEAEs, and serious TEAEs (SAEs) were assessed in subgroups who did/did not receive carbamazepine (CBZ) at study entry (CBZ+ and CBZ-). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2018.06.002DOI Listing
September 2018
22 Reads
2.015 Impact Factor

Place-based screening of mixtures of dominant emerging contaminants measured in Lake Michigan using zebrafish embryo gene expression assay.

Chemosphere 2018 Feb 10;193:1226-1234. Epub 2017 Nov 10.

School of Freshwater Sciences, University of Wisconsin, Milwaukee, Milwaukee, WI 53204, USA. Electronic address:

Determining impacts of emerging contaminants is difficult due to the different concentrations of mixtures of these chemicals over a landscape. Assessment approaches need to account for absorption, distribution, metabolism and excretion of the chemicals in an organism, and potential crosstalk between molecular pathways. The goal of this study was to assess the utility of employing a modified zebrafish embryo toxicity (ZFET) assay that assesses morphological alterations and measurements of estrogen-associated mRNA transcripts, to exposure of a mixtures of chemicals at concentrations measured in several locations in Lake Michigan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2017.11.043DOI Listing
February 2018
5 Reads

Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee.

Genet Med 2019 02 1;21(2):382-390. Epub 2018 Jun 1.

Pharmacogenomics Analysis Laboratory, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

Purpose: The Veterans Health Administration (VHA) Clinical Pharmacogenetics Subcommittee is charged with making recommendations about whether specific pharmacogenetic tests should be used in healthcare at VHA facilities. We describe a process to inform VHA pharmacogenetic testing policy.

Methods: After developing consensus definitions of clinical validity and utility, the Subcommittee identified salient drug-gene pairs with potential clinical application in VHA. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41436-018-0057-x
Publisher Site
http://dx.doi.org/10.1038/s41436-018-0057-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274593PMC
February 2019
23 Reads

Nystagmus Associated with Carbamazepine Toxicity.

Clin Pract Cases Emerg Med 2017 Nov 18;1(4):441-442. Epub 2017 Oct 18.

Lakeland Health, Department of Emergency Medicine, Saint Joseph, Michigan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5811/cpcem.2017.6.34772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965243PMC
November 2017
2 Reads

Chronic exposure to cannabidiol induces reproductive toxicity in male Swiss mice.

J Appl Toxicol 2018 Sep 16;38(9):1215-1223. Epub 2018 May 16.

Department of Pharmacology, Laboratory of Physiology and Pharmacology of Reproduction, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Children and adults with frequent and severe episodes of epilepsy that do not respond to standard treatments (such as carbamazepine, phenytoin and valproate) have long been prescribed cannabidiol (CBD) as an anticonvulsant drug. However, the safety of its chronic use in relation to reproduction has not been fully examined. This study aimed to assess the effects of chronic CBD exposure on the male reproductive system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3631DOI Listing
September 2018
7 Reads

A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents.

Biomed Res Int 2018 22;2018:3201203. Epub 2018 Mar 22.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/3201203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885346PMC
October 2018
7 Reads

Opiate-Free Pain Therapy Using Carbamazepine-Loaded Microparticles Provides Up to 2 Weeks of Pain Relief in a Neuropathic Pain Model.

Pain Pract 2018 11 14;18(8):1024-1035. Epub 2018 Jun 14.

PixarBio Corporation, Salem, New Hampshire, U.S.A.

Introduction: Opioids remain a mainstay in the treatment of acute and chronic pain, despite numerous and potentially dangerous side effects. There is a great unmet medical need for alternative treatments for patients suffering from pain that do not result in addiction or adverse side effects. Anticonvulsants have been shown to be effective in managing pain, though high systemic levels and subsequent side effects limit their widespread usage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/papr.12705DOI Listing
November 2018
4 Reads
2.361 Impact Factor

Endocrine disruptors in breeding ponds and reproductive health of toads in agricultural, urban and natural landscapes.

Sci Total Environ 2018 Sep 18;634:1335-1345. Epub 2018 Apr 18.

Lendület Evolutionary Ecology Research Group, Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, 1022 Budapest, Hungary.

Many chemical pollutants have endocrine disrupting effects which can cause lifelong reproductive abnormalities in animals. Amphibians are the most threatened group of vertebrates, but there is little information on the nature and quantity of pollutants occurring in typical amphibian breeding habitats and on the reproductive capacities of amphibian populations inhabiting polluted areas. In this study we investigated the occurrence and concentrations of endocrine disrupting chemicals in the water and sediment of under-studied amphibian breeding habitats in natural, agricultural and urbanized landscapes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.03.363DOI Listing
September 2018
7 Reads

Detection of Bisphenol A in aqueous medium by screen printed carbon electrodes incorporating electrochemical molecularly imprinted polymers.

Biosens Bioelectron 2018 Jul 21;112:156-161. Epub 2018 Apr 21.

Laboratoire MAPIEM, EA 4323, Université de Toulon, 83041 Toulon Cedex 9, France. Electronic address:

Electrochemical molecularly imprinted polymers (e-MIPs) were for the first time introduced in screen-printed carbon electrodes (SPCE) as the sensing element for the detection of an organic pollutant. To play this sensing role, a redox tracer was incorporated inside the binding cavities of a cross-linked MIP, as a functional monomer during the synthesis step. Ferrocenylmethyl methacrylate was used for this purpose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bios.2018.04.022DOI Listing
July 2018
9 Reads

PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization.

Int J Pharm 2018 Jun 17;544(1):191-202. Epub 2018 Apr 17.

Laboratorio de Biomembranas, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Grupo de Biología Estructural y Biotecnología, IMBICE, CONICET, CICPBA, Roque Sáenz Peña 352, Bernal, Buenos Aires, Argentina. Electronic address:

Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient pharmacokinetic profiles, and multiple side effects. PAMAM dendrimers, ethylenediamine core, generation 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.04.032DOI Listing
June 2018
10 Reads

Comparison of different advanced degradation processes for the removal of the pharmaceutical compounds diclofenac and carbamazepine from liquid solutions.

Environ Sci Pollut Res Int 2018 Oct 18;25(28):27704-27723. Epub 2018 Apr 18.

Department of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.

Carbamazepine and diclofenac are two examples of drugs with widespread geographical and environmental media proliferation that are poorly removed by traditional wastewater treatment processes. Advanced oxidation processes (AOPs) have been proposed as alternative methods to remove these compounds in solution. AOPs are based on a wide class of powerful technologies, including UV radiation, ozone, hydrogen peroxide, Fenton process, catalytic wet peroxide oxidation, heterogeneous photocatalysis, electrochemical oxidation and their combinations, sonolysis, and microwaves applicable to both water and wastewater. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-018-1913-6DOI Listing
October 2018
8 Reads

Transformation Products of Carbamazepine (CBZ) After Ozonation and their Toxicity Evaluation Using sp. Strain KSH-1 in Aqueous Matrices.

Indian J Microbiol 2018 Jun 8;58(2):193-200. Epub 2018 Mar 8.

1CSIR-National Environmental Engineering Research Institute (NEERI), Nehru Marg, Nagpur, 440020 India.

Carbamazepine (CBZ) is an anti-epileptic and anti-convulsant drug widely used for the treatment of epilepsy and other bipolar disorders. Ozone as an advanced oxidation process has been widely used for the degradation of CBZ resulting in the formation of transformation products (ozonides). The present research aims to isolate and identify potential microorganism, capable of degradation of CBZ and its transformation products. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12088-018-0715-3
Publisher Site
http://dx.doi.org/10.1007/s12088-018-0715-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891479PMC
June 2018
4 Reads

Enhanced pharmaceutical removal from water in a three step bio-ozone-bio process.

Water Res 2018 07 12;138:97-105. Epub 2018 Mar 12.

Sub-department of Environmental Technology, Wageningen University & Research, 6700 AA Wageningen, The Netherlands. Electronic address:

Individual treatment processes like biological treatment or ozonation have their limitations for the removal of pharmaceuticals from secondary clarified effluents with high organic matter concentrations (i.e. 17 mg TOC/L). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2018.03.028DOI Listing
July 2018
4 Reads

Insights into influencing factor, degradation mechanism and potential toxicity involved in aqueous ozonation of oxcarbazepine (CHEM46939R1).

Chemosphere 2018 Jun 9;201:189-196. Epub 2018 Feb 9.

School of Environment and Civil Engineering, Jiangnan University, Wuxi 214122, China; Jiangsu Key Laboratory of Anaerobic Biotechnology, Jiangnan University, Wuxi 214122, China.

Oxcarbazepine (OXC), as a potent antiepileptic drug, is widely used in recent years, but its residue is potentially harmful to the environment. Although ozonation is a high-efficient technology for chemical oxidation during water treatment, it cannot completely mineralize organic matters, but partially transforms them into some unidentified by-products. In order to provide more insight into OXC ozonation process, the influencing factor, transformation mechanism and potential toxicity were comprehensively investigated in this study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535183026
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2018.02.062DOI Listing
June 2018
10 Reads

Toxicity assessment of pharmaceutical compounds on mixed culture from activated sludge using respirometric technique: The role of microbial community structure.

Sci Total Environ 2018 Jul 27;630:809-819. Epub 2018 Feb 27.

Department of Environmental and Natural Resources Management, University of Patras, Agrinio, Greece.

Micropollutants of emerging concern such as pharmaceuticals can significantly affect the performance of secondary biological processes in wastewater treatment plants. The present study is aimed to evaluate the toxicity and inhibition of three pharmaceutical compounds (caffeine, sulfamethoxazole and carbamazepine) on two cultures of microbial consortia enriched from wastewater aerobic activated sludge. One of them was acclimated to pharmaceuticals and the other was non-acclimated as control bioassay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.02.095DOI Listing
July 2018
7 Reads

Effects of single and combined exposure of pharmaceutical drugs (carbamazepine and cetirizine) and a metal (cadmium) on the biochemical responses of R. philippinarum.

Aquat Toxicol 2018 May 19;198:10-19. Epub 2018 Feb 19.

Biology Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In the aquatic environment, organisms are exposed to complex mixtures of contaminants which may alter the toxicity profile of each compound, compared to its toxicity alone. Pharmaceutical drugs (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2018.02.011DOI Listing
May 2018
6 Reads

Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio).

Aquat Toxicol 2018 May 10;198:1-9. Epub 2018 Feb 10.

Department of Biology, McMaster University, 1280 Main Street West, Hamilton, L8S 4K1, ON, Canada. Electronic address:

Gemfibrozil (GEM) and carbamazepine (CBZ) are two environmentally relevant pharmaceuticals and chronic exposure of fish to these compounds has decreased androgen levels and fish reproduction in laboratory studies. The main focus of this study was to examine the effects of GEM and CBZ on testicular steroid production, using zebrafish as a model species. Chronic water borne exposures of adult zebrafish to 10 μg/L of GEM and CBZ were conducted and the dosing was confirmed by chemical analysis of water as 17. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2018.02.006DOI Listing
May 2018
6 Reads

Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries.

J Toxicol Sci 2018 ;43(2):75-87

Department of Drug Safety Sciences, Nagoya University Graduate School of Medicine.

Several drugs have been withdrawn from the market or restricted to avoid unexpected adverse outcomes. Drug-induced liver injury (DILI) is a serious issue for drug development. Among DILIs, idiosyncratic DILIs have been a serious problem in drug development and clinical uses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2131/jts.43.75DOI Listing
April 2018
5 Reads

Investigation of pharmaceutically active compounds in an urban receiving water: Occurrence, fate and environmental risk assessment.

Ecotoxicol Environ Saf 2018 Jun 22;154:214-220. Epub 2018 Feb 22.

Key Laboratory of Integrated Regulation and Resources Development, College of Environment, Hohai University, Nanjing 210098, China.

Pharmaceutically active compounds (PhACs) recently have been recognized to constitute a health risk for aquatic ecosystems. The major pathways of PhACs to enter the aquatic environment are excretion and discharge of effluents through sewage treatment plants (STPs). The occurrence, bioaccumulation and risk assessment of lipophilic PhACs, including erythromycin, ketoconazole, indomethacin, diclofenac, gemfibrozil, bezafibrate, propranolol, carbamazepine, sertraline and 17α-ethinylestradiol were investigated in a river that receives effluents from STP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2018.02.052DOI Listing
June 2018
13 Reads