1,340 results match your criteria Toxicity Carbamazepine

Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications.

Curr Neuropharmacol 2022 May 24. Epub 2022 May 24.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia and IRCCS Mondino Foundation, Pavia, Italy.

Antiseizure medications and drugs for psychiatric diseases are frequently used in combination. In this context pharmacokinetic interactions between these drugs may occur. The vast majority of these interactions are primarily observed at a metabolic level and result from changes in the activity of the cytochrome P450 (CYP). Read More

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Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/β-Catenin Signaling Pathway.

ACS Chem Neurosci 2022 May 2;13(10):1594-1603. Epub 2022 May 2.

School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.

Several plant compounds have been found to possess neuroactive properties. The aim of this study was to investigate the anticonvulsant effect of eupafolin, a major active component extracted from , a herb used in traditional medicine for its anti-inflammatory properties. To this end, we assessed the anticonvulsant effects of eupafolin in rats intraperitoneally (i. Read More

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Efficient Oxidation of Paracetamol Triggered by Molecular-Oxygen Activation at β-Cyclodextrin-Modified Titanate Nanotubes.

Chem Asian J 2022 Apr 25:e202200352. Epub 2022 Apr 25.

State Environmental Protection Key Lab of Environmental Risk Assessment and Control on Chemical Processes, School of Resources & Environmental Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P.R. China.

Titanate nanotubes (TNTs) were coated with a cyclic oligosaccharide (carboxymethyl-β-cyclodextrin, CM-β-CD) to obtain a photocatalyst (CM-β-CD-TNT) for efficiently activating molecular oxygen and removing the target contaminant. The hydrophobic cavity and the large specific surface area of the photocatalyst provide abundant active sites for activating molecular oxygen. The free radical capture experiment and quenching experiment showed that cyclodextrin could facilitate adsorption and activation of molecular oxygen to produce O . Read More

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Severe Carbamazepine Toxicity Treated with Continuous Venovenous Hemofiltration at Palestine Medical Complex: Two Case Reports.

Int Med Case Rep J 2022 17;15:205-208. Epub 2022 Apr 17.

Intensive Care Unit, Palestine Medical Complex, Ramallah, Palestine.

Carbamazepine intoxication is not uncommon and accounts for many cases of poisoning among anticonvulsive medications users. Since there is no specific antidote for carbamazepine overdose, management is limited to gastric decontamination and supportive therapy. With its high protein binding, the role of extracorporeal elimination in carbamazepine intoxication is still questionable. Read More

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Evolution of Pharmacogenomics and the Importance of PGx Data Integration in Health Care System: A 10 Years Retrospective Study in Thailand.

Front Pharmacol 2022 5;13:866903. Epub 2022 Apr 5.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

The is the most polymorphic gene, play a crucial role in drug-induced hypersensitivity reactions. There is a lot of evidence associating several risk alleles to life-threatening adverse drug reactions, and a few of them have been approved as valid biomarkers for predicting life-threatening hypersensitivity reactions. The objective of this present study is to present the progression of pharmacogenomics (PGx) testing in the Thai population during a 10-year period, from 2011 to 2020. Read More

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Integrative Analysis of Pharmacokinetic and Metabolomic Profiles for Predicting Metabolic Phenotype and Drug Exposure Caused by Sotorasib in Rats.

Front Oncol 2022 5;12:778035. Epub 2022 Apr 5.

Department of Pharmacy, Research Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Sotorasib is a novel targeted inhibitor of Kirsten rat sarcoma (KRAS) (G12C) that has shown exciting tumor-suppressing effects not only for single targeted agents but also for combination with immune checkpoint inhibitors. However, no integrative analysis of the pharmacokinetics (PK) and pharmacometabolomics (PM) of sotorasib has been reported to date. In the present study, a sensitive and robust high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was firstly developed and fully validated for the quantitation of sotorasib in rat plasma. Read More

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Degradation of Carbamazepine from Aqueous Solutions via TiO-Assisted Photo Catalyze.

Toxics 2022 Mar 31;10(4). Epub 2022 Mar 31.

National Research and Development Institute for Industrial Ecology-ECOIND, 57-73 Drumul Podu Dambovitei, Sector 6, 060652 Bucharest, Romania.

Photocatalytic degradation of carbamazepine (CBZ) from spiked aqueous solutions, via a UV/TiO system, was investigated, and the optimum photocatalyst type (P25 Degussa) and dose (500 mg/L), as well as irradiation time (45 min), were established. The degradation process kinetics was studied, and a degradation rate constant of 3.14 × 10 M min was calculated for CBZ, using the Langmuir-Hinshelwood equation. Read More

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Glucose-PEG2000-DSPE modified carbamazepine nano system alleviated cell apoptosis and oxidative stress in epilepsy.

Nucleosides Nucleotides Nucleic Acids 2022 Apr 15:1-13. Epub 2022 Apr 15.

Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Investigations on the effects of newly constructed glucose-PEG2000-DSPE modified carbamazepine nano system on oxidative stress damage and cell apoptosis in epilepsy. The nano system was constructed by egg yolk lecithin, cholesterol, GLUPEG2000-DSPE, and carbamazepine as per the molar ratio of 95:20:5:6.35. Read More

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Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects.

J Pharm Biomed Anal 2022 May 5;214:114751. Epub 2022 Apr 5.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, PR China; The First Hospital of Jilin University, Jilin University, Xinmin Street, Changchun 130061, PR China. Electronic address:

Therapeutic drug monitoring of carbamazepine is necessary for its clinical application with the purpose to reach therapeutic concentration and reduce the risk of concentration-dependent toxicity. An ultrafast analytical assay for quantification of carbamazepine in human plasma was developed and validated based on direct analysis in real time tandem mass spectrometry (DART-MS/MS). After reversed phase solid phase extraction with Waters Oasis HLB, carbamazepine and internal standard carbamazepine-DN were monitored by positive ion mode followed by multiple reaction monitoring (MRM) of the transitions at m/z 237. Read More

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Chronic toxicity of diclofenac, carbamazepine and their mixture to Daphnia magna: a comparative two-generational study.

Environ Sci Pollut Res Int 2022 Apr 4. Epub 2022 Apr 4.

Key Laboratory of Integrated Regulation and Resources, Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, People's Republic of China.

The chronic toxicity of diclofenac (DCF) and carbamazepine (CBZ) as separate substances and in conjunction with their mixture on Daphnia magna was assessed in the parental (F0) and first filial (F1) generations. The second (F1-B2) and fifth (F1-B5) broods of F1 offspring were investigated and compared. Both drugs and their mixture were exposed to each generation of Daphnia magna for 21 days with life history, behavioural and gene expressions as measured endpoints. Read More

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Highly efficient activation of peracetic acid by nano-CuO for carbamazepine degradation in wastewater: The significant role of HO and evidence of acetylperoxy radical contribution.

Water Res 2022 Jun 19;216:118322. Epub 2022 Mar 19.

State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Key Laboratory of Yangtze Water Environment for Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, China. Electronic address:

Peracetic acid (PAA)-based advanced oxidation processes (AOPs) has attracted increasing attentions towards contaminant degradation in the wastewater treatment. Herein, we report the efficient activation of PAA by nano-CuO (nCuO/PAA) to degrade carbamazepine (CBZ) for the first time. Rapid degradation of CBZ was observed in the nCuO/PAA system at neutral initial pH. Read More

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The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.

Acta Neurol Belg 2022 Mar 24. Epub 2022 Mar 24.

Service de Neurologie, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria.

Despite a dramatic increase in treatment options over the past 30 years, Carbamazepine (CBZ) is still considered the standard of care and the most prescribed initial treatment for focal epilepsy. Hence, the identification of genetic biomarkers that influence the response, resistance and toxicity to CBZ remains a challenge. Several research studies have looked into this to highlight the polymorphisms responsible for the variability in the response to CBZ in patients with epilepsy. Read More

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Elimination of recalcitrant micropollutants by medium pressure UV-catalyzed bioelectrochemical advanced oxidation process: Influencing factors, transformation pathway and toxicity assessment.

Sci Total Environ 2022 Jul 15;828:154543. Epub 2022 Mar 15.

Department of Environmental Engineering, Technical University of Denmark, DK-2800 Lyngby, Denmark. Electronic address:

Bio-electro-Fenton (BEF) processes have been widely studied in recent years to remove recalcitrant micropollutants from wastewater. Though promising, it still faces the critical challenge of residual iron and iron sludge in the treated effluent. Thus, an innovative medium-pressure ultraviolet-catalyzed bio-electrochemical system (MUBEC), in which medium-pressure ultraviolet was employed as an alternative to iron for in-situ HO activation, was developed for the removal of recalcitrant micropollutants. Read More

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Simultaneous Quantification of 11 Antiseizure Medications and Metabolites in Serum for Therapeutic Drug Monitoring Using High-Performance Liquid Chromatography with Ultraviolet Detection: A Short Communication.

Ther Drug Monit 2022 04;44(2):345-350

Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany; and.

Background: Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) is widely used to guide therapy, avoid toxicity, and assess patient compliance. Commercial immunologic quantification methods are common practice; however, as they are only applicable to one specific drug and prone to cross-reacting metabolites, their practical applicability is limited. In this article, the authors proposed a high-performance liquid chromatography method using ultraviolet detection (HPLC-UV) for simultaneous quantification of 11 ASMs and active metabolites (carbamazepine, felbamate, lacosamide, lamotrigine, levetiracetam, phenobarbital, phenytoin, primidone, zonisamide, carbamazepine-10,11-epoxide, and licarbazepine) in serum. Read More

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Comprehensive assessment of chemical residues in surface and wastewater using passive sampling, chemical, biological, and fish behavioral assays.

Sci Total Environ 2022 Jul 1;828:154176. Epub 2022 Mar 1.

Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, NY 14260, USA. Electronic address:

Effluents from ten full-scale municipal wastewater treatment plants (WWTPs) that discharge into the Hudson River, surface waters, and wild-caught fish samples were analyzed using liquid chromatography with tandem mass spectrometry (LC/MS/MS) to examine the influence of wastewater discharge on the concentrations of contaminants of emerging concern (CECs) and their ecological impacts on fish. Analysis was based on targeted detection of 41 pharmaceuticals, and non-targeted analysis (suspect screening) of CECs. Biological effects of treated WWTP effluents were assessed using a larval zebrafish (Danio rerio) swimming behavior assay. Read More

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Exposure to anti-seizure medications impact growth of gut bacterial species and subsequent host response.

Neurobiol Dis 2022 06 17;167:105664. Epub 2022 Feb 17.

Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Domaine de Vilvert, Jouy-en-Josas 78350, France. Electronic address:

Anti-seizure medications (ASMs) are the first line of treatment for seizure control in children with epilepsy. Cumulative evidence suggests an imbalanced gut microbiota in refractory epilepsy patients. We systematically investigated the differential antimicrobial impacts of nine ASM active ingredients, seven common excipients of ASMs, and four syrup formulations on core early-life gut microbiota strains. Read More

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Oxidative stress and metal homeostasis alterations in Danio rerio (zebrafish) under single and combined carbamazepine, acetamiprid and cadmium exposures.

Aquat Toxicol 2022 Apr 13;245:106122. Epub 2022 Feb 13.

Programa de Pós-Graduação em Saúde Pública e Meio Ambiente, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, Av. Leopoldo Bulhões 1480, 21041-210 Rio de Janeiro, RJ, Brazil; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz. Av. Brasil, 4.365, Manguinhos. 21040-360, Rio de Janeiro, Brasil. Electronic address:

Contaminants of emerging concern (CEC) are routinely detected in aquatic environments, especially pharmaceuticals, such as carbamazepine (CBZ), and neonicotinoid pesticides, like acetamiprid (ACT). CECs can interact with each other and with other legislated contaminants like Cd, resulting in unknown effects. Most studies evaluate only the effects of single contaminant exposures on aquatic biota. Read More

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Toxicometabolomics and Biotransformation Product Elucidation in Single Zebrafish Embryos Exposed to Carbamazepine from Environmentally-Relevant to Morphologically Altering Doses.

Chem Res Toxicol 2022 03 15;35(3):431-439. Epub 2022 Feb 15.

Department of Environmental Science, Stockholm University, 114 18 Stockholm, Sweden.

Toxicometabolomics and biotransformation product (bioTP) elucidation were carried out in single zebrafish (ZF) embryos exposed to carbamazepine (CBZ). Exposures were conducted in 96-well plates containing six CBZ concentrations ranging from 0.5 μg/L to 50 mg/L ( = 12 embryos per dose). Read More

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Marine heatwaves hamper neuro-immune and oxidative tolerance toward carbamazepine in Mytilus galloprovincialis.

Environ Pollut 2022 May 7;300:118970. Epub 2022 Feb 7.

Dipartimento di Scienze Della Vita e Dell'Ambiente, Università Politecnica Delle Marche, Via Brecce Bianche, Ancona, Italy. Electronic address:

The increased frequency and intensity of short-term extreme warming phenomena have been associated to harsh biological and ecosystem outcomes (i.e., mass mortalities in marine organisms). Read More

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Metabolic, cellular and defense responses to single and co-exposure to carbamazepine and methylmercury in Dreissena polymorpha.

Environ Pollut 2022 May 2;300:118933. Epub 2022 Feb 2.

Université de Reims Champagne-Ardenne, UMR-I 02 INERIS-URCA-ULH SEBIO, Unité Stress Environnementaux et BIOsurveillance des Milieux Aquatiques (SEBIO), BP 1039 F, 51687, Reims, Cedex, France. Electronic address:

Carbamazepine (CBZ) and Hg are widespread and persistent micropollutants in aquatic environments. Both pollutants are known to trigger similar toxicity mechanisms, e.g. Read More

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Responses of Ruditapes philippinarum to contamination by pharmaceutical drugs under ocean acidification scenario.

Sci Total Environ 2022 Jun 2;824:153591. Epub 2022 Feb 2.

Biology Department & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

In coastal systems, organisms are exposed to a multitude of stressors whose interactions and effects are poorly studied. Pharmaceutical drugs and Climate Change consequences, such as lowered pH, are examples of stressors affecting marine organisms, as bivalves. Although a vast literature is available for the effects of these stressors when acting individually, very limited information exists on the impacts that the combination of both can have on marine bivalves. Read More

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Neurologic toxicity of carbamazepine in treatment of trigeminal neuralgia.

Am J Emerg Med 2022 05 21;55:231.e3-231.e5. Epub 2022 Jan 21.

Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX 78234, United States.

Carbamazepine is a medication used to treat a variety of neurological and psychiatric conditions including seizure disorders, neuropathic pain syndromes, and bipolar disorder. Unfortunately, its pharmacokinetics and side effect profile may lead to significant toxicities due to its sodium channel blockade. In 2019, there were over 1500 cases of isolated carbamazepine toxicity reported to poison centers across the United States. Read More

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Metal-oxide coated Graphene oxide nano-composite for the treatment of pharmaceutical compound in photocatalytic reactor: Batch, Kinetics and Mathematical Modeling using Response Surface Methodology and Artificial Neural Network.

Environ Sci Pollut Res Int 2022 Jan 23. Epub 2022 Jan 23.

Department of Chemical Engineering, Indian Institute of Technology, Guwahati, India.

Titanium dioxide (TiO) photocatalyst has gained constant interest in the treatment of wastewater because of its greater stability, lower cost, low-toxicity, high efficiency, and more reactivity under UV radiation. On the other hand, Graphene oxide (GO) possesses high electron mobility, and therefore when GO is combined with TiO the photocatalytic activity of TiO is increased. In this study, nano-composite was synthesized in a hydrothermal reactor using two types of TiO nanoparticles (TiO consisting of a mixture of rutile and anatase phase (Type 1) and bioreduced TiO (Type 2)) and the efficiency of both the TiO-GO nanocomposite to remove the drug Carbamazepine (CBZ) was investigated. Read More

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January 2022

Effect of Carbamazepine, Ibuprofen, Triclosan and Sulfamethoxazole on Anaerobic Bioreactor Performance: Combining Cell Damage, Ecotoxicity and Chemical Information.

Toxics 2022 Jan 17;10(1). Epub 2022 Jan 17.

Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33,600, 28871 Alcala de Henares, Spain.

Pharmaceuticals and personal care products (PPCPs) are partially degraded in wastewater treatment plants (WWTPs), thereby leading to the formation of more toxic metabolites. Bacterial populations in bioreactors operated in WWTPs are sensitive to different toxics such as heavy metals and aromatic compounds, but there is still little information on the effect that pharmaceuticals exert on their metabolism, especially under anaerobic conditions. This work evaluated the effect of selected pharmaceuticals that remain in solution and attached to biosolids on the metabolism of anaerobic biomass. Read More

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January 2022

Effects of carbamazepine in aquatic biota.

Environ Sci Process Impacts 2022 Feb 23;24(2):209-220. Epub 2022 Feb 23.

Université Reims Champagne Ardenne, UMR-I 02 SEBIO, 51100 Reims, France.

Carbamazepine (CBZ) is one of the most common pharmaceuticals found in the aquatic environment. Here, we reviewed studies in aquatic animals highlighting that CBZ affected ROS homeostasis but also the neuroendocrine system, cell viability, immunity, reproduction, feeding behavior and growth. Notably, the acetylcholinesterase activity was modified by concentrations of the order of ng L CBZ. Read More

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February 2022

Bioconcentration of neuroactive pharmaceuticals in fish: Relation to lipophilicity, experimental design and toxicity in the aquatic environment.

Sci Total Environ 2022 Mar 23;812:152543. Epub 2021 Dec 23.

MARE - Marine and Environmental Sciences Centre, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal; Departamento de Biologia Animal, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Uptake of contaminants is linked to their toxicity and is usually estimated through their lipophilicity (logK). Here, we review current literature regarding bioconcentration, i.e. Read More

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Influence of nanoparticle size on blood-brain barrier penetration and the accumulation of anti-seizure medicines in the brain.

J Mater Chem B 2022 01 5;10(2):271-281. Epub 2022 Jan 5.

Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.

Anti-seizure medicines constitute a common yet important modality to treat epilepsy. However, some of them are associated with serious side effects including hepatotoxicity and hypersensitivity. Furthermore, the blood-brain barrier (BBB) is an insurmountable obstacle for brain drug delivery. Read More

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January 2022

Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae.

Int J Mol Sci 2021 Nov 24;22(23). Epub 2021 Nov 24.

Comparative Perinatal Development, Department of Veterinary Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.

The zebrafish () embryo is gaining interest as a bridging tool between in-vitro and in-vivo developmental toxicity studies. However, cytochrome P450 (CYP)-mediated drug metabolism in this model is still under debate. Therefore, we investigated the potential of zebrafish embryos and larvae to bioactivate two known anti-epileptics, carbamazepine (CBZ) and phenytoin (PHE), to carbamazepine-10,11-epoxide (E-CBZ) and 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), respectively. Read More

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November 2021

Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat.

Drug Chem Toxicol 2021 Dec 8:1-8. Epub 2021 Dec 8.

Department of Medical Biology, Faculty of Medicine, Firat University, Elazig, Turkey.

Carbamazepine (CBZ) is the antiepileptic drug used in epilepsy and some psychiatric disorders. Besides its widely used, many adverse effects have been reported including hematotoxicity, hepatotoxicity, endocrine disorders, and testicular damages due to oxidative stress. However, the role of CBZ on renal toxicity is not fully known. Read More

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December 2021

Ba substituted SrTiO induced lattice deformation for enhanced piezocatalytic removal of carbamazepine from water.

J Hazard Mater 2022 02 8;424(Pt B):127440. Epub 2021 Oct 8.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Jinan University, Guangzhou 511443, China.

Removal of pharmaceuticals and personal care products (PPCPs) from water by mechanical energy-driven piezocatalysis is a promising technology for environmental remediation that highly depends on the design of efficient piezocatalyst. In this study, Ba-substituted SrTiO piezoelectric materials were constructed and used for piezocatalytic degradation of carbamazepine (CBZ) from water. The BaSrTiO (BSTO-2) achieved the optimal performance, exhibiting 94. Read More

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February 2022