1,256 results match your criteria Toxicity Carbamazepine

The graceful art, significant function and wide application behavior of ultrasound research and understanding in carbamazepine (CBZ) enhanced removal and degradation by Fe/PDS/US.

Chemosphere 2021 Apr 2;278:130368. Epub 2021 Apr 2.

School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou, 510006, Guangdong, China.

Carbamazepine (CBZ) antibiotic organic contamination wastewater poses a huge threat to environmental safety. An advanced oxidation technology (Fe/PDS/US) of using ultrasound (US) enhanced zero-valent iron/potassium persulfate (Fe/PDS) can remove CBZ effectively. The optimal reaction conditions were determined by exploring the effect of single-factor experimental conditions such as ultrasonic power, ultrasonic frequency, CBZ concentration, solution pH, PDS dosage, and Fe dosage on the removal of CBZ. Read More

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FeS/carbon felt as an efficient electro-Fenton cathode for carbamazepine degradation and detoxification: In-depth discussion of reaction contribution and empirical kinetic model.

Environ Pollut 2021 Mar 27;282:117023. Epub 2021 Mar 27.

Institute of Environment Engineering and Research, University of Engineering and Technology, GT Road, 54890, Lahore, Punjab, Pakistan.

Carbamazepine (CBZ) decay by electro-Fenton (EF) oxidation using a novel FeS/carbon felt (CF) cathode, instead of a soluble iron salt, was studied with the aim to accelerate the reaction between HO and ferrous ions, which helps to produce more hydroxyl radicals (OH) and eliminate iron sludge. First, fabricated FeS and its derived cathode were characterized by scanning electron microscopy, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy. Anodes were then screened, with DSA (Ti/IrO-RuO) showing the best performance under EF oxidation regarding CBZ degradation and electrochemical characterization. Read More

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A review of pharmacokinetic drug interactions between antimicrobial and antiseizure medications in children.

Epileptic Disord 2021 Apr 2. Epub 2021 Apr 2.

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.

Comorbidity between epilepsy and infectious diseases in children is frequent. Pharmacokinetic drug-drug interactions (DDIs) between antiseizure medications (ASMs) and anti-infectives can occur and influence their efficacy or cause toxicity. All potential DDIs between ASMs and antimicrobial agents used in children were identified through consultation of drug compendia. Read More

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Systems Medicine Design for Triple-Negative Breast Cancer and Non-Triple-Negative Breast Cancer Based on Systems Identification and Carcinogenic Mechanisms.

Int J Mol Sci 2021 Mar 17;22(6). Epub 2021 Mar 17.

Laboratory of Automatic Control, Signaling Processing and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancers with poor prognosis. The etiology of triple-negative breast cancer (TNBC) is involved in various biological signal cascades and multifactorial aberrations of genetic, epigenetic and microenvironment. New therapeutic for TNBC is urgently needed because surgery and chemotherapy are the only available modalities nowadays. Read More

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Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of : its interaction with anxiolytic-hypnotics.

Drug Metab Pers Ther 2020 Dec 29. Epub 2020 Dec 29.

Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria.

Objectives: Concurrent use of herbs with drugs have become a major healthcare problem. Herb-drug interactions could lead to therapeutic failure or toxicity. Hence, this study seeks to evaluate the impact of combining rhizome (CL) with selected anxiolytic and hypnotic drugs. Read More

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December 2020

Occurrence of carbamazepine, diclofenac, and their related metabolites and transformation products in a French aquatic environment and preliminary risk assessment.

Water Res 2021 May 15;196:117052. Epub 2021 Mar 15.

Institut de Chimie des Milieux et Matériaux de Poitiers, UMR CNRS 7285, University of Poitiers, France. Electronic address:

With questions emerging on the presence and risks associated with metabolites and transformation products (TPs) of organic contaminants in the aquatic environment, progress has been made in terms of monitoring and regulation of pesticide metabolites. However, less interest is shown for pharmaceutical residues, although their pseudo-persistence and adverse effects on non-target organisms are proven. This study provides original knowledge about the contamination of ten sites located along three French rivers (water, sediments, biofilms, clams) by pharmaceutical metabolites and TPs, as well as a preliminary environmental risk assessment. Read More

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Drug level monitoring in palliative patients.

BMJ Support Palliat Care 2021 Mar 16. Epub 2021 Mar 16.

Medical, John Taylor Hospice, Birmingham, UK

Palliative medicine is always patient centred and promotes the principle that no unnecessary investigations are performed. The case is reported of a patient with suspected carbamazepine toxicity presenting as progression of symptoms of primary brain tumour. A comparison is made of the symptoms and signs of toxicity versus tumour, and an aid for deciding when to perform therapeutic drug level monitoring for some common drugs. Read More

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Gene alteration in zebrafish exposed to a mixture of substances of abuse.

Environ Pollut 2021 Jun 24;278:116777. Epub 2021 Feb 24.

Department of Biology, Murray State University, Murray, KY, United States.

A recent surge in the use and abuse of diverse prescribed psychotic and illicit drugs necessitates the surveillance of drug residues in source water and the associated ecological impacts of chronic exposure to the aquatic organism. Thirty-six psychotic and illicit drug residues were determined in discharged wastewater from two centralized municipal wastewater treatment facilities and two wastewater receiving creeks for seven consecutive days in Kentucky. Zebrafish (Danio rerio) larvae were exposed to the environmental relevant mixtures of all drug residues, all illicit drugs, and all prescribed psychotic drugs. Read More

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Efficient photoactivation of peroxymonosulfate by Z-scheme nitrogen-defect-rich NiCoO/g-CN for rapid emerging pollutants degradation.

J Hazard Mater 2021 Feb 27;414:125528. Epub 2021 Feb 27.

Key Laboratory of Groundwater Resources and Environment, Ministry of Education, Jilin University, Changchun 130021, Jilin, China; Jilin Provincial Key Laboratory of Water Resources and Environment, Jilin University, Changchun 130021, Jilin, China. Electronic address:

Limited peroxymonosulfate (PMS, HSO) activation efficiency resulted from slow metal reduction has been a challenge in visible-light (vis) assisted sulfate radical-based oxidation. Herein, a Z-scheme photocatalyst composed of nitrogen-defect-rich graphitic carbon nitride nanosheets embedded with nickel cobaltate nanoparticles (NiCoO/g-CN-N) was elaborately designed to accelerate Ni(III)/Ni(II) and Co(III)/Co(II) cycles for PMS activation in PMS/vis system. The NiCoO/g-CN-N exhibited remarkable enhancement with a tetracycline hydrochloride (TCH) degradation rate constant (0. Read More

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February 2021

Application of (V)UV/O technology for post-treatment of biologically treated wastewater: A pilot-scale study.

Chemosphere 2021 Jul 23;275:130080. Epub 2021 Feb 23.

Laboratory for Environmental Chemistry and Bioanalytics, Institute of Chemistry, ELTE - Eötvös Loránd University, H-1117, Budapest, Pázmány Péter Sétány 1/A, Hungary; Cooperative Research Center for Environmental Sciences, ELTE - Eötvös Loránd University, H-1117, Budapest, Pázmány Péter Sétány 1/A, Hungary; Centre for Ecological Research, Danube Research Institute, H-1113, Budapest, Karolina út 29-31, Hungary. Electronic address:

For the first time, high energy VUV photons and generation of O by (V)UV lamps were applied together for removal of active pharmaceutical ingredients (APIs) from biologically treated wastewater (BTWW) in pilot-scale. The core of the pilot container unit was a photoreactor assembly consisting of six photoreactors, each containing a low-pressure Hg lamp (UV dose of 1.2 J/cm and 6. Read More

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Knowledge of epilepsy among German pharmacists.

Epilepsy Res 2021 May 17;172:106587. Epub 2021 Feb 17.

Neuropaediatrics, University Hospital for Children and Adolescents, Ernst-Heydemann-Straße 8, 18057 Rostock, Germany. Electronic address:

Problem: Pharmacists can have a large impact on attitude, acceptance and adherence in patients with long-term conditions. They should be able to give appropriate advice.

Methods: We invited pharmacists in Mecklenburg-Vorpommern and Saxony, Germany, to complete a questionnaire mainly containing multiple-choice-questions. Read More

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Carbamazepine induces hepatotoxicity in zebrafish by inhibition of the Wnt/β-catenin signaling pathway.

Environ Pollut 2021 May 6;276:116688. Epub 2021 Feb 6.

Center for Developmental Biology of Jinggangshan University, College of Life Sciences, Jinggangshan University, Ji'an, 343009, Jiangxi, China; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Ji'an, 343009, Jiangxi, China; Center for Drug Screening and Research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.

As drug abuse has become increasingly serious, carbamazepine (CBZ) is discharged into the aquatic environment with municipal sewage, causing potential harm to aquatic organisms. Here, we utilized zebrafish, an aquatic vertebrate model, to comprehensively evaluate the hepatotoxicity of CBZ. The larvae were exposed to 0. Read More

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Prospects on coupling UV/HO with activated sludge or a fungal treatment for the removal of pharmaceutically active compounds in real hospital wastewater.

Sci Total Environ 2021 Jun 2;773:145374. Epub 2021 Feb 2.

Departament d'Enginyeria Química Biològica i Ambiental, Escola d'Enginyeria, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address:

Conventional active sludge (AS) process at municipal centralized wastewater treatment facilities may exhibit little pharmaceuticals (PhACs) removal efficiencies when treating hospital wastewater (HWW). Therefore, a dedicated efficient wastewater treatment at the source point is recommended. In this sense, advanced oxidation processes (AOPs) and fungal treatment (FG) have evidenced promising results in degrading PhACs. Read More

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Advancing the treatment of primary influent and effluent wastewater during wet weather flow by single versus powdered activated carbon-catalyzed ozonation for the removal of trace organic compounds.

Sci Total Environ 2021 May 17;770:144679. Epub 2021 Jan 17.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada. Electronic address:

For the first time, single and PAC-catalyzed ozonation were explored for the wastewater treatment during wet weather flow in a prompt and efficient process. The effect of varying the ozone (O) specific dose on the removal of micropollutants (MPs) was first investigated with a mixture of pharmaceuticals, herbicides and perfluorinated compounds in clean water. Most MPs showed higher affinity towards catalytic ozonation. Read More

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Pharmaceuticals in farms and surrounding surface water bodies: Hazard and ecotoxicity in a swine production area in Costa Rica.

Chemosphere 2021 Jun 8;272:129574. Epub 2021 Jan 8.

Centro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, 2060, San José, Costa Rica. Electronic address:

The presence of pharmaceuticals in the environment is known to have multiple origins; livestock activities comprise one scarcely studied source, both globally and specially in Latin-America. This work aims to study the occurrence of pharmaceuticals in wastewater from swine farms and their surrounding surface waters, in a highland livestock production area of Costa Rica. The monitoring of 70 pharmaceutical active compounds resulted in the detection of 10 molecules in farm wastewater (influents and effluents of the on-farm treatment system), including compounds of animal and human use. Read More

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Complex effects of eslicarbazepine on inhibitory micro networks in chronic experimental epilepsy.

Epilepsia 2021 02 16;62(2):542-556. Epub 2021 Jan 16.

Medical Faculty, Institute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.

Objective: Many antiseizure drugs (ASDs) act on voltage-dependent sodium channels, and the molecular basis of these effects is well established. In contrast, how ASDs act on the level of neuronal networks is much less understood.

Methods: In the present study, we determined the effects of eslicarbazepine (S-Lic) on different types of inhibitory neurons, as well as inhibitory motifs. Read More

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February 2021

Electrochemical degradation of psychotropic pharmaceutical compounds from municipal wastewater and neurotoxicity evaluations.

Environ Sci Pollut Res Int 2021 Jan 4. Epub 2021 Jan 4.

CIEPQPF - Research Centre of Chemical Process Engineering and Forest Products, Department of Chemical Engineering, University of Coimbra, P-3030-790, Coimbra, Portugal.

Contaminants of emerging concern (CECs) are released daily into surface water, and their recalcitrant properties often require tertiary treatment. Electrochemical oxidation (EO) is often used as an alternative way to eliminate these compounds from water, although the literature barely addresses the neurotoxic effects of residual by-products. Therefore, this study investigated the performance of EO in the removal of five CECs (alprazolam, clonazepam, diazepam, lorazepam, and carbamazepine) and performed neurotoxicity evaluations of residual EO by-products in Wistar rat brain hippocampal slices. Read More

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January 2021

Carbamazepine at environmentally relevant concentrations caused DNA damage and apoptosis in the liver of Chinese rare minnows (Gobiocypris rarus) by the Ras/Raf/ERK/p53 signaling pathway.

Environ Pollut 2021 Feb 16;270:116245. Epub 2020 Dec 16.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Beijing Key Laboratory of Industrial Wastewater Treatment and Reuse, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100085, China. Electronic address:

To assess genetoxicity and the underlying mechanisms of carbamazepine (CBZ) toxicity in fish, adult Chinese rare minnows (Gobiocypris rarus) were exposed to 1, 10, and 100 μg/L CBZ for 28 d. Comet assays indicated that hepatic DNA damage was significantly increased in groups of minnows exposed to CBZ at all concentrations in a dose-dependent manner compared to those of the control groups (p < 0.05). Read More

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February 2021

Immunity and inflammatory responses in gilthead sea bream (Sparus aurata L.) exposed to sub-lethal mixture of carbamazepine, cadmium chloride and polybrominated diphenyl ether.

Fish Shellfish Immunol 2021 Apr 23;111:25-35. Epub 2020 Dec 23.

University of Palermo, Dept. of Earth and Marine Science DISTEM, Laboratory of Marine Biochemistry and Ecotoxicology, Via Barlotta 4, 91100, Trapani, Italy; Istituto per lo studio degli impatti Antropici e Sostenibilità in ambiente marino (IAS), Consiglio Nazionale delle Ricerche, Capo Granitola, Trapani, Italy; Consorzio Universitario della Provincia di Trapani, Marine Biology Institute, Via Barlotta 4, 91100, Trapani, Italy.

Chemical contaminants such as industrial and urban by-products, pharmaceuticals, drugs metabolites and, plastics, are continuously found in the oceans, affecting its quality and organism's welfare. Although these compounds are found at concentrations ranged ng L, there is an increasing concern about the potential adverse effects of the interactions among those substances present, simultaneously, in a mixture. In the present study, specimens of sea bream (Sparus aurata) were exposed, by food, to rising concentrations of a mixture of carbamazepine, polybrominated diphenyl ether-47 and cadmium chloride, for 15 days and then, maintained, with the same control diet, without contaminants, for other 15 days. Read More

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Removal of pharmaceutical metabolites in wastewater ozonation including their fate in different post-treatments.

Sci Total Environ 2021 Mar 30;759:143989. Epub 2020 Nov 30.

Aarhus University, Department of Environmental Science, Frederiksborgvej 399, 4000 Roskilde, Denmark. Electronic address:

Advanced treatment technologies for the removal of pharmaceuticals and other organic micropollutants in WWTPs primarily target the removal of parent compounds. Nevertheless, the removal of metabolites originating from human- or microbial metabolism during biological treatment needs comparable consideration, as some of them might be present in high concentrations and contribute to toxicity. This study was conducted to elucidate the removal of human and microbial metabolites of pharmaceuticals as a function of the specific ozone dose. Read More

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Graded doses of grape seed methanol extract attenuated hepato-toxicity following chronic carbamazepine treatment in male Wistar rats.

Toxicol Rep 2020 24;7:1592-1596. Epub 2020 Nov 24.

Department of Physiology, Faculty of Basic Medical Sciences, Osun State University Osogbo, Nigeria.

Aim: This study investigated the effects of co-administration of carbamazepine (CBZ) with grape () seed methanolic extract (GSME) on liver toxicity.

Method: Thirty-five male rats (145-155 g) were randomized into 5 groups (n = 7) and administered with propylene glycol (PG 0.1 mL/day), CBZ (25 mg/kg), CBZ (25 mg/kg) + GSME (200 mg/kg), CBZ (25 mg/kg) + GSME (100 mg/kg), or CBZ (25 mg/kg) + GSME (50 mg/kg) orally for 28 days. Read More

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November 2020

Emerging pharmaceuticals and industrial chemicals in Nakdong River, Korea: Identification, quantitative monitoring, and prioritization.

Chemosphere 2021 Jan 18;263:128014. Epub 2020 Aug 18.

Graduate School of FEED of Eco-Friendly Offshore Structure, Changwon National University, Changwon, Gyeongsangnamdo, 51140, South Korea; School of Civil, Environmental and Chemical Engineering, Changwon National University, Changwon, Gyeongsangnamdo, 51140, South Korea; Department of Smart Ocean Environmental Energy, Changwon National University, Changwon, Gyeongsangnamdo, 51140, South Korea. Electronic address:

The extensive development and use of new anthropogenic chemicals have inevitably led to their presence in aquatic environments. Surface waters affected by sewage effluents have been exposed to these new substances. In the present study, the occurrence of anthropogenic substances, including pharmaceuticals and industrial chemicals, was investigated in one of the major rivers in Korea, the Nakdong River. Read More

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January 2021

Emerging organic compounds in European groundwater.

Environ Pollut 2021 Jan 3;269:115945. Epub 2020 Nov 3.

BRGM, (French Geological Survey) BP 6009, 45060, Orléans Cedex 2, France.

In Europe, emerging organic compounds (EOCs) in groundwater is a growing research area. Prioritisation for monitoring EOCs in Europe was formalised in 2019 through the development of the first voluntary groundwater watch list (GWWL). Despite this, groundwater occurrence data in the peer reviewed literature for Europe has not been reviewed to date. Read More

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January 2021

Environmentally relevant concentrations of carbamazepine induced lipid metabolism disorder of Chinese rare minnow (Gobiocypris rarus) in a gender-specific pattern.

Chemosphere 2021 Feb 25;265:129080. Epub 2020 Nov 25.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Beijing Key Laboratory of Industrial Wastewater Treatment and Reuse, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100085, China. Electronic address:

Carbamazepine (CBZ), an anticonvulsant and mood stabilizer, is ubiquitous distributed in aquatic environment. Though the toxicity and endocrine disrupting effect of CBZ on non-target organisms have been studied, its lipotoxity are scarcely known. To assess the lipotoxicity of CBZ, 2-month-old Chinese rare minnow were exposed to 0, 1, 10, and 100 μg/L CBZ for 90 d. Read More

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February 2021

Development and Molecular Investigation into the Effects of Carbamazepine Exposure in the Zebrafish ().

Int J Environ Res Public Health 2020 11 29;17(23). Epub 2020 Nov 29.

Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.

Concerns regarding environmental exposures and the impacts of pharmaceuticals on non-target aquatic organisms continue to increase. The antiepileptic drug carbamazepine (CBZ) is often detected as an aquatic contaminant and can disrupt various behaviors of fishes. However, there are few reports which investigate the mechanism of CBZ action in fish. Read More

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November 2020

In vivo γ-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach.

Epilepsia 2021 01 1;62(1):163-175. Epub 2020 Dec 1.

Grenoble Institut Neurosciences (GIN), Grenoble Alpes University, Inserm, U1216, Grenoble, France.

Objective: Following surgery, focal seizures relapse in 20% to 50% of cases due to the difficulty of delimiting the epileptogenic zone (EZ) by current imaging or electrophysiological techniques. Here, we evaluate an unbiased metabolomics approach based on ex vivo and in vivo nuclear magnetic resonance spectroscopy (MRS) methods to discriminate the EZ in a mouse model of mesiotemporal lobe epilepsy (MTLE).

Methods: Four weeks after unilateral injection of kainic acid (KA) into the dorsal hippocampus of mice (KA-MTLE model), we analyzed hippocampal and cortical samples with high-resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS). Read More

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January 2021

Graded doses of grape seed methanol extract attenuated ataxic movement, cerebellocortical toxicity, and impairment following chronic carbamazepine treatment in male Wistar rats.

Epilepsy Behav 2021 01 27;114(Pt A):107484. Epub 2020 Nov 27.

Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University Osogbo, Nigeria.

This study investigated the effects of chronic cotreatment of carbamazepine (CBZ) with grape seed methanolic extract (GSME) on the markers of neurotoxicity and motor coordination in male rats. Thirty male Wistar rats were randomized into 5 groups (n = 6) and treated orally with propylene glycol (PG 0.1 ml/day), CBZ (25 mg/kg), CBZ (25 mg/kg) + GSME (200 mg/kg), CBZ (25 mg/kg) + GSME (100 mg/kg), or CBZ (25 mg/kg) + GSME (50 mg/kg) for 28 days. Read More

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January 2021

Insights into catalytic activation of peroxymonosulfate for carbamazepine degradation by MnO nanoparticles in-situ anchored titanate nanotubes: Mechanism, ecotoxicity and DFT study.

J Hazard Mater 2021 01 30;402:123779. Epub 2020 Aug 30.

College of Environmental Sciences and Engineering, Peking University, The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing, 100871, PR China; The Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT), Peking University, Beijing, 100871, PR China; Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University, Tianjin, 300350, PR China. Electronic address:

Developing efficient pharmaceuticals and personal care products (PPCPs) degradation technologies is of scientifical and practical importance to restrain their discharge into natural water environment. This study fabricated and applied a composite material of amorphous MnO nanoparticles in-situ anchored titanate nanotubes (AMnTi) to activate peroxymonosulfate (PMS) for efficient degradation and mineralization of carbamazepine (CBZ). The degradation pathway and toxicity evolution of CBZ during elimination were deeply evaluated through produced intermediates identification and theoretical calculations. Read More

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January 2021

Environmental pharmaceuticals and climate change: The case study of carbamazepine in M. galloprovincialis under ocean acidification scenario.

Environ Int 2021 01 25;146:106269. Epub 2020 Nov 25.

Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche (60131), Ancona, Italy. Electronic address:

Contaminants of emerging concern and ocean changes are key environmental stressors for marine species with possibly synergistic, but still unexplored, deleterious effects. In the present study the influence of a simulated ocean acidification scenario (pH = 7.6) was investigated on metabolism and sub-lethal effects of carbamazepine, CBZ (1 µg/L), chosen as one of the most widely diffused pharmaceuticals in marine organisms. Read More

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January 2021

Can ocean warming alter sub-lethal effects of antiepileptic and antihistaminic pharmaceuticals in marine bivalves?

Aquat Toxicol 2021 Jan 2;230:105673. Epub 2020 Nov 2.

Biology Department & CESAM, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address:

The negative effects induced in marine organisms by Climate Change related abiotic factors consequences, namely ocean warming, are well-known. However, few works studied the combined impacts of ocean warming and contaminants, as pharmaceutical drugs. Carbamazepine (CBZ) and cetirizine (CTZ) occur in the marine environment, showing negative effects in marine organisms. Read More

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January 2021