1,823 results match your criteria Toxicity Caffeine


Caffeine, a natural methylxanthine nutraceutical, exerts dopaminergic neuroprotection.

Neurochem Int 2021 May 15;148:105066. Epub 2021 May 15.

Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA. Electronic address:

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects more than 10 million people worldwide. Oxidative stress and mitochondrial dysfunction play a significant role in altering the homeostasis of energy production and free radical generation. Current PD therapies are focused on reducing the cardinal symptoms rather than preventing disease progression in the patients. Read More

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Assessing the distributions and fate of household and personal care chemicals (HPCCs) in the Songhua Catchment, Northeast China.

Sci Total Environ 2021 Sep 3;786:147484. Epub 2021 May 3.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.

Many household and personal care chemicals (HPCCs) are of environmental concern due to their potential toxicity to humans and wildlife. However, few studies investigate the spatiotemporal variations and fate of HPCCs in large-scale river systems. Here, river water and sediment samples from the Songhua River in Northeast China were analyzed for seven classes of HPCCs. Read More

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September 2021

Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.

Toxicology 2021 May 7;457:152811. Epub 2021 May 7.

Department of Medicine, USA; Marion Bessin Liver Research Center, USA; Department of Pathology, USA; Diabetes Center, USA; Fleischer Institute for Diabetes and Metabolism, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:

Preterm infants are at greater risk for adverse drug effects due to hepatic immaturity. Multiple interventions during intensive care increases potential for drug interactions. In this setting, high-dose caffeine used for apnea in premature infants may increase acetaminophen toxicity by inhibiting ataxia telangiectasia mutated (ATM) gene activity during DNA damage response. Read More

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The recent advance of organic fluorescent probe rapid detection for common substances in beverages.

Food Chem 2021 Oct 20;358:129839. Epub 2021 Apr 20.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Key laboratory of Flavor Chemistry, Beijing Technology and Business University, Beijing 100048, PR China.

The beverage industry is confronted with tremendous challenges in terms of quality assurance. The allowed contents of common ingredients such as copper ions, hydrogen sulfide, cysteine and caffeine are stipulated by various governing bodies, and the beverage industry must ensure that it meets these requirements. Due to its unique advantages of high sensitivity, low cost and relatively low toxicity over high-performance liquid chromatography, atomic absorption spectrometry and nanomaterials, the use of organic fluorescent probes for the rapid detection of beverage contents has become a hot research topic. Read More

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October 2021

Caffeine-Cyclodextrin Complexes as Solids: Synthesis, Biological and Physicochemical Characterization.

Int J Mol Sci 2021 Apr 18;22(8). Epub 2021 Apr 18.

International Institute of Molecular and Cell Biology in Warsaw, Księcia Trojdena 4, 02-109 Warsaw, Poland.

Mechanochemical and in-solution synthesis of caffeine complexes with α-, β-, and γ-cyclodextrins was optimized. It was found that short-duration, low-energy cogrinding, and evaporation (instead of freeze-drying) are effective methods for the formation and isolation of these complexes. The products obtained, their pure components, and their mixtures were examined by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), FT-IR and Raman spectroscopy. Read More

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New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.

Regul Toxicol Pharmacol 2021 Apr 24;123:104931. Epub 2021 Apr 24.

Beiersdorf, Unnastrasse 48, 20253, Hamburg, Germany.

This case study on the model substance caffeine demonstrates the viability of a 10-step read-across (RAX) framework in practice. New approach methodologies (NAM), including RAX and physiologically-based kinetic (PBK) modelling were used to assess the consumer safety of caffeine. Appropriate animal systemic toxicity data were used from the most relevant RAX analogue while assuming that no suitable animal toxicity data were available for caffeine. Read More

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Severe Caffeine Intoxication Treated With Hemodialysis: A Case Report.

Kidney Med 2021 Mar-Apr;3(2):299-302. Epub 2021 Feb 6.

Division of Nephrology, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada.

Caffeine is well known for its central nervous system-stimulating effect. Toxicity may occur following high-dose caffeine ingestions. We describe a case of caffeine intoxication secondary to reported ingestion of a large dose of caffeine (60,000 mg in tablet form) with an initial serum caffeine level of 608 μmol/L (known lethal serum level starting from 412 μmol/L). Read More

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February 2021

Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report.

BMC Psychiatry 2021 04 13;21(1):192. Epub 2021 Apr 13.

Westmead Hospital Intensive Care Unit, Sydney, Australia.

Background: Caffeine is a known inhibitor of Clozapine metabolism mediated by inhibition of CYP1A2. Hitherto, the effects of caffeine on Clozapine levels have always been modest, as have the clinical manifestations of toxicity resulting from their interaction. We present a case of severe toxicity associated with the co-consumption of caffeine and Clozapine culminating in life-threatening complications requiring management in Intensive Care. Read More

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TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder.

Food Chem 2021 Sep 13;355:129563. Epub 2021 Mar 13.

Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos 6627, Belo Horizonte, 31270-901 Minas Gerais, Brazil. Electronic address:

Paullinia cupana Kunth., commonly named Guaraná, is a plant from Brazil used as stimulant. The aim of this study was to evaluate the potential of extracts and tannins-rich and methylxanthines-free fraction from guaraná in the anti-inflammatory and antioxidant effect in vitro. Read More

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September 2021

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors.

Front Cell Dev Biol 2021 9;9:586767. Epub 2021 Mar 9.

Division of Histology and Embryology, International Joint Laboratory for Embryonic Development and Prenatal Medicine, Medical College, Jinan University, Guangzhou, China.

Whether or not the process of somitogenesis and myogenesis is affected by excessive caffeine intake still remains ambiguous. In this study, we first showed that caffeine treatment results in chest wall deformities and simultaneously reduced mRNA expressions of genes involved in myogenesis in the developing chicken embryos. We then used embryo cultures to assess in further detail how caffeine exposure affects the earliest steps of myogenesis, and we demonstrated that the caffeine treatment suppressed somitogenesis of chicken embryos by interfering with the expressions of crucial genes modulating apoptosis, proliferation, and differentiation of myogenic progenitors in differentiating somites. Read More

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The roles of HO, ClO and BrO radicals in caffeine degradation: A theoretical study.

Sci Total Environ 2021 May 23;768:144733. Epub 2021 Jan 23.

Environment Research Institute, Shandong University, Qingdao 266237, PR China. Electronic address:

ClO and BrO are newly discovered reactive radicals that contribute to the degradation of micropollutants. However, the research on pollutant degradation by ClO and BrO is still lacking. Thus, the mechanism, kinetics, and toxicity of caffeine degradation by HO, ClO, and BrO were computationally studied and compared. Read More

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Effects of temperature on caffeine and carbon nanotubes co-exposure in Ruditapes philippinarum.

Chemosphere 2021 May 27;271:129775. Epub 2021 Jan 27.

Department of Biology & CESAM, University of Aveiro, 3810-193, Portugal. Electronic address:

In the marine environment, organisms are exposed to a high and increasing number of different contaminants that can interact among them. In addition, abiotic factors can change the dynamics between contaminants and organisms, thus increasing or even decreasing the toxic effect of a particular compound. In this study, the effects of caffeine (CAF) and functionalized multi-walled carbon nanotubes (f-MWCNTs) induced in the clam Ruditapes philippinarum were evaluated, acting alone and in combination (MIX), under two temperature levels (18 and 21 °C). Read More

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Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling.

FASEB J 2021 Feb;35(2):e21370

Department of Joint Surgery and Sports Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

Caffeine has developmental toxicity. Prenatal caffeine exposure (PCE) caused intrauterine growth retardation (IUGR) and multiple organ dysplasia. This study intended to explore the effect and mechanism of PCE on long bone development in female fetal rats. Read More

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February 2021

Caffeine as a contaminant of periphyton: ecological changes and impacts on primary producers.

Ecotoxicology 2021 May 17;30(4):599-609. Epub 2021 Mar 17.

Laboratory of Limnology, Department of Ecology, Institute of Bioscience, University of São Paulo, Rua do Matão 321, CEP 05508-090, São Paulo, SP, Brazil.

Every day, tons of caffeine is consumed by humans in beverages, medications or supplements, and a significant amount of this stimulant is released in domestic sewage. Once in aquatic environments caffeine interacts directly with the periphytic community, which is responsible for a significant part of primary production in aquatic ecosystems. However, the effects of exposure to caffeine are mostly unknown for both the periphyton and their predators. Read More

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Long-term ecotoxicological effects of ciprofloxacin in combination with caffeine on the microalga .

Toxicol Rep 2021 23;8:429-435. Epub 2021 Feb 23.

Department of Hydraulics and Sanitation, São Carlos School of Engineering, University of São Paulo, São Carlos, Brazil.

Ciprofloxacin (CIP) is an antimicrobial "pseudo-persistent" in aquatic ecosystems. Once dispersed in the water compartments, it can also affect the microalgae. Thus, the evaluation of its long-term ecotoxicological effects is necessary. Read More

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February 2021

Vitamin D Status of Very Low Birth Weight Neonates at Baseline and Follow-up after Daily Intake of 800 IU Vitamin D.

J Trop Pediatr 2021 01;67(1)

Community Medicine and Public Health King George's Medical University, Uttar Pradesh, Lucknow 226003, India.

Introduction: Vitamin D deficiency (VDD) is rampant in neonates. Recommendations for supplementation are variable.

Methods: An observational study was done on less than 32 weeks of very low birth weight neonates to find prevalence of VDD (<20 ng/ml) at baseline; at 38 ± 2 weeks post-menstrual age (PMA) after daily intake of 800 IU vitamin D (vit D). Read More

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January 2021

Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science.

Br J Anaesth 2021 May 26;126(5):996-1008. Epub 2021 Feb 26.

Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Background: Novel preventive therapies are needed for postoperative delirium, which especially affects older patients. A mouse model is presented that captures inflammation-associated cortical slow wave activity (SWA) observed in patients, allowing exploration of the mechanistic role of prostaglandin-adenosine signalling.

Methods: EEG and cortical cytokine measurements (interleukin 6, monocyte chemoattractant protein-1) were obtained from adult and aged mice. Read More

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The impact of acute energy drink consumption on electrical heart disease: A systematic review and meta-analysis.

J Electrocardiol 2021 Mar-Apr;65:128-135. Epub 2021 Feb 9.

Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.

Aims: Energy Drink (ED)-associated cardiovascular emergency visits have increased in recent years. Although a toxicity threshold has been established for caffeine, the safety profile of whole ED consumption has not yet been defined.

Methods: This systematic review was conducted following the PRISMA guidelines. Read More

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February 2021

Sublethal and lethal effects of the imidacloprid on the metabolic characteristics based on high-throughput non-targeted metabolomics in Aphis gossypii Glover.

Ecotoxicol Environ Saf 2021 Apr 6;212:111969. Epub 2021 Feb 6.

Department of Entomology, China Agricultural University, Beijing 100193, China. Electronic address:

Sublethal effect considered as an emerging factor to assess the environmental risk of insecticides, which can impact the insects on both physiology and behavior. Lethal exposure can be causing near immediate mortality. Pests are inevitably exposed to sublethal and lethal dose in the agroecosystem following application of pesticides. Read More

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How temperature can alter the combined effects of carbon nanotubes and caffeine in the clam Ruditapes decussatus?

Environ Res 2021 04 5;195:110755. Epub 2021 Feb 5.

Department of Biology, University of Aveiro, 3810-193, Portugal; Department of Biology & CESAM, University of Aveiro, 3810-193, Portugal. Electronic address:

Nowadays, multi-walled carbon nanotubes are considered to be emerging contaminants and their impact in ecosystem has drawn special research attention, while other contaminants, such as caffeine, have more coverage in literature. Despite this, the effects of a combination of the two has yet to be evaluated, especially considering predicted temperature rise. In the present study a typical bioindicator species for marine environment, the clam Ruditapes decussatus, and classical tools, such as biomarkers and histopathological indices, were used to shed light on the species' response to these contaminants, under actual and predicted warming scenarios. Read More

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Clozapine intoxication with severe adverse effects induced by an inflammatory and infectious process: a case report.

J Med Case Rep 2021 Feb 8;15(1):47. Epub 2021 Feb 8.

Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, 5400, Boulevard Gouin Ouest, Montreal, QC, H4J1C5, Canada.

Background: Clozapine intoxication can be life-threatening. Outside of the common drug-drug interactions, tobacco smoking, and caffeine consumption, infectious and inflammatory processes are important contributors to clozapine intoxication. Although this relationship has been reported previously, the literature is scant of proper research articles describing the presentation and management of this unpredictable interaction. Read More

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February 2021

Evaluation of chemical compounds that inhibit neurite outgrowth using GFP-labeled iPSC-derived human neurons.

Neurotoxicology 2021 03 27;83:137-145. Epub 2021 Jan 27.

Division for Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Due to the increasing number of drugs and untested environmental compounds introduced into commercial use, there is recognition for a need to develop reliable and efficient screening methods to identify compounds that may adversely impact the nervous system. One process that has been implicated in neurodevelopment is neurite outgrowth; the disruption of which can result in adverse outcomes that persist later in life. Here, we developed a green fluorescent protein (GFP) labeled neurite outgrowth assay in a high-content, high-throughput format using induced pluripotent stem cell (iPSC) derived human spinal motor neurons and cortical glutamatergic neurons. Read More

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Pharmaceuticals in farms and surrounding surface water bodies: Hazard and ecotoxicity in a swine production area in Costa Rica.

Chemosphere 2021 Jun 8;272:129574. Epub 2021 Jan 8.

Centro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, 2060, San José, Costa Rica. Electronic address:

The presence of pharmaceuticals in the environment is known to have multiple origins; livestock activities comprise one scarcely studied source, both globally and specially in Latin-America. This work aims to study the occurrence of pharmaceuticals in wastewater from swine farms and their surrounding surface waters, in a highland livestock production area of Costa Rica. The monitoring of 70 pharmaceutical active compounds resulted in the detection of 10 molecules in farm wastewater (influents and effluents of the on-farm treatment system), including compounds of animal and human use. Read More

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Association between self-reported caffeine intake during pregnancy and social responsiveness scores in childhood: The EARLI and HOME studies.

PLoS One 2021 15;16(1):e0245079. Epub 2021 Jan 15.

Department of Epidemiology, Brown University, Providence, Rhode Island, United States of America.

Maternal nutrition during gestation has been investigated for its role in child neurodevelopment. However, little is known about the potential impact of gestational caffeine exposure on child autistic behaviors. Here, we assess the relation between maternal caffeine intake during pregnancy and children's behavioral traits related to Autism Spectrum Disorder (ASD). Read More

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Emerging contaminant occurrence and toxic effects on zebrafish embryos to assess the adverse effects caused by mixtures of substances in the environment.

Environ Sci Pollut Res Int 2021 Apr 6;28(16):20313-20329. Epub 2021 Jan 6.

Centro de Química e Meio Ambiente, Instituto de Pesquisas Energéticas e Nucleares, São Paulo, Brazil.

The contaminants of emerging concern (CECs) have been receiving global attention due to their worldwide presence in water bodies. The CECs could be originated from synthetic or natural sources, and they are not commonly monitored, although these substances are continuously reaching the aquatic environment. The main goal of this study was to determine the occurrence of some target CECs in São Paulo state surface water, once there is practically no information on the presence and concentration range of these substances at the studied sites. Read More

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Persulfate mediated solar photo-Fenton aiming at wastewater treatment plant effluent improvement at neutral PH: emerging contaminant removal, disinfection, and elimination of antibiotic-resistant bacteria.

Environ Sci Pollut Res Int 2021 Apr 4;28(14):17355-17368. Epub 2021 Jan 4.

Department of Sanitary and Environmental Engineering, Research Group on Environmental Applications of Advanced Oxidative Processes, Universidade Federal de Minas Gerais, UFMG, Presidente Antônio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil.

This work investigated an innovative alternative to improve municipal wastewater treatment plant effluent (MWWTP effluent) quality aiming at the removal of contaminants of emerging concern (caffeine, carbendazim, and losartan potassium), and antibiotic-resistant bacteria (ARB), as well as disinfection (E. coli). Persulfate was used as an alternative oxidant in the solar photo-Fenton process (solar/Fe/SO) due to its greater stability in the presence of matrix components. Read More

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Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity.

Cardiovasc Toxicol 2021 Apr 3;21(4):322-335. Epub 2021 Jan 3.

Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Yunus Emre Campus, 26470, Eskisehir, Turkey.

Consumption of illicit pharmaceutical products containing sibutramine has been reported to cause cardiovascular toxicity problems. This study aimed to demonstrate the toxicity profile of sibutramine, and thereby provide important implications for the development of more effective strategies in both clinical approaches and drug design studies. Action potentials (APs) were determined from freshly isolated ventricular cardiomyocytes with whole-cell configuration of current clamp as online. Read More

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Occurrence, distribution, and potential health risks of psychoactive substances in Chinese surface waters.

J Hazard Mater 2021 04 14;407:124851. Epub 2020 Dec 14.

Department of Environmental Science & Engineering, Fudan University, Shanghai 200433 PR China. Electronic address:

Ten psychoactive substances (PSs) and metabolites were identified and quantified in 217 surface water samples collected across China to reveal the occurrence, distribution, and potential health risks in Chinese surface waters. The results showed the ubiquitous occurrence of caffeine (CFI), paraxanthine (PXT) and cotinine (CTN) at all the monitored sites, the concentrations of which ranged from not detected to 3460 ng L, while the remaining PSs were detected at trace levels (<50 ng L). High concentrations of diet-related PSs (CTN, CFI, and PXT) typically occurred in areas with high population densities. Read More

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Biological, histological and immunohistochemical studies on the toxicity of spent coffee grounds and caffeine on the larvae of Aedes aegypti (Diptera: Culicidae).

Environ Pollut 2021 Feb 17;271:116307. Epub 2020 Dec 17.

Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil; Departamento de Entomologia, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address:

The mosquito Aedes aegypti is a primary vector for major arboviruses, and its control is mainly based on the use of insecticides. Caffeine and spent coffee grounds (CG) are potential agents in controlling Ae. aegypti by reducing survival and blocking larval development. Read More

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February 2021

Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS).

Toxicology 2021 01 8;448:152651. Epub 2020 Dec 8.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. Electronic address:

A human microfluidic four-cell liver acinus microphysiology system (LAMPS), was evaluated for reproducibility and robustness as a model for drug pharmacokinetics and toxicology. The model was constructed using primary human hepatocytes or human induced pluripotent stem cell (iPSC)-derived hepatocytes and 3 human cell lines for the endothelial, Kupffer and stellate cells. The model was tested in two laboratories and demonstrated to be reproducible in terms of basal function of hepatocytes, Terfenadine metabolism, and effects of Tolcapone (88 μM), Troglitazone (150 μM), and caffeine (600 μM) over 9 days in culture. Read More

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January 2021