1,673 results match your criteria Toxicity Caffeine


Energy drinks in children and adolescents: demographic data and immediate effects.

Eur J Pediatr 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Department, Saint Vincent De Paul Hospital, Faculty of Medicine, Bar-Ilan University, PO box 50294, 16102, Nazareth, Israel.

Energy drinks consumption has become increasingly common in the last few years, despite evidence associating these products with vast adverse health effects. This led us to explore the phenomenon of energy drinks consumption in adolescents in the Israeli Arab population of the Nazareth area (Northern Israel), examining their awareness of risks associated with consumption of energy drinks, investigating their immediate effects on the body. Our study revealed that the consumption of energy drinks is very common in adolescents of both sexes, though more common in boys. Read More

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http://dx.doi.org/10.1007/s00431-019-03342-7DOI Listing
February 2019

Caffeine and oocyte vitrification: Sheep as an animal model.

Int J Vet Sci Med 2018 13;6(Suppl):S41-S48. Epub 2018 Feb 13.

Animal Development and Biotechnology Group, School of Biosciences, The University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK.

Oocyte cryopreservation is valuable way of preserving the female germ line. Vitrification of immature ovine oocytes decreased the levels of both maturation promoting factor (MPF) and mitogen-activated protein kinase (MAPK) in metaphase II (MII) oocytes after IVM. Our aims were 1) to evaluate the effects of vitrification of ovine GV-oocytes on spindle assembly, MPF/MAP kinases activities, and preimplantation development following IVM and IVF, 2) to elucidate the impact of caffeine supplementation during IVM on the quality and development of vitrified/warmed ovine GV-oocytes. Read More

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http://dx.doi.org/10.1016/j.ijvsm.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161861PMC
February 2018

Caffeine Toxicity Following Ingestion of an Exercise Supplement by a Patient with Type 1 Diabetes.

Authors:
Ehab Hamed

Eur J Case Rep Intern Med 2018 24;5(10):000957. Epub 2018 Oct 24.

Family Medicine Consultant, Primary Health Care Corporation, Doha, Qatar.

We report the case of a patient with type 1 diabetes who developed acute severe diabetic ketoacidosis following ingestion of an energy supplement containing caffeine. Some 95% of the US adult population consume caffeine, and the general perception is that there are no negative consequences for health. The upper limit of safe consumption is less than 400 mg per day. Read More

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http://dx.doi.org/10.12890/2018_000957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346890PMC
October 2018

UV radiation on scalp skin surface induces scalp hair follicle damage ex vivo and is alleviated by the topical treatment with caffeine.

Int J Cosmet Sci 2019 Feb 11. Epub 2019 Feb 11.

Monasterium Laboratory GmbH, Muenster, Germany.

Objectives: While the effect of ultraviolet radiation (UVR) on human skin has been extensively studied, very little is known on how UVR impacts on hair follicle (HF) homeostasis. Here, we investigated how solar spectrum UVR that hits the human skin surface impacts on HF biology, and whether any detrimental effects can be mitigated by a widely used cosmetic and nutraceutical ingredient, caffeine.

Methods: Human scalp skin with terminal HFs was irradiated transepidermally ex vivo using either 10 J/cm UVA (340-440 nm) + 20 mJ/cm UVB (290-320 nm) (low dose) or 50 J/cm UVA + 50 mJ/cm UVB (high dose) and organ-cultured under serum-free conditions for 1 or 3 days. Read More

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http://dx.doi.org/10.1111/ics.12521DOI Listing
February 2019
2 Reads

Co-digestion of microalgae and primary sludge: Effect on biogas production and microcontaminants removal.

Sci Total Environ 2019 Apr 3;660:974-981. Epub 2019 Jan 3.

GEMMA - Environmental Engineering and Microbiology Research Group, Department of Civil and Environmental Engineering, Universitat Politècnica de Catalunya·BarcelonaTech, c/ Jordi Girona 1-3, Building D1, E-08034 Barcelona, Spain. Electronic address:

Microalgal-based wastewater treatment plants are conceived as low cost and low energy consuming systems. The operation of these plants involves the management of primary sludge and microalgal biomass. The aim of this study is to analyse the anaerobic co-digestion of both by-products in terms of biogas production and contaminants of emerging concern removal. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.011DOI Listing
April 2019
1 Read

Behavioral profile alterations in zebrafish larvae exposed to environmentally relevant concentrations of eight priority pharmaceuticals.

Sci Total Environ 2019 Jan 24;664:89-98. Epub 2019 Jan 24.

Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany. Electronic address:

Although the effects of pharmaceuticals on aquatic organisms have been widely investigated during the last decades, toxic effects, especially delayed toxicity, during the developmental stage at environmental relevant concentrations were rarely known. In this study, a sensitive assay based on behavioral alterations was used for studying the delayed toxicity during the developmental stage on zebrafish embryos. Eight pharmaceuticals that were frequently detected with concentrations ranging from ng/l to μg/l were screened for this study. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.300DOI Listing
January 2019
1 Read

Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling.

Ecotoxicol Environ Saf 2019 Jan 31;172:232-239. Epub 2019 Jan 31.

Universidad San Jorge, Campus Universitario, Autov A23 km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The final fate of many drugs is release into the natural aquatic environment. It is necessary to assess the toxicity caused by this situation and the associated concerns for human beings. Zebrafish (Danio rerio) is a common biomodel used to assess toxicity in aquatic environments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.081DOI Listing
January 2019
1 Read

Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Br J Clin Pharmacol 2019 Feb 1. Epub 2019 Feb 1.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, USA.

Aims: CYP2A6 is a genetically polymorphic enzyme resulting in differential substrate metabolism and health behaviors. Current phenotyping probes for CYP2A6 exhibit limitations related to procurement (deuterated cotinine), toxicity (coumarin), specificity (caffeine), and age-appropriate administration (nicotine, NIC). In vitro, CYP2A6 selectively forms 2-hydroxymetronidazole (2HM) from metronidazole (MTZ). Read More

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http://dx.doi.org/10.1111/bcp.13884DOI Listing
February 2019
2 Reads

Cardiotoxicity of environmental contaminant tributyltin involves myocyte oxidative stress and abnormal Ca handling.

Environ Pollut 2019 Jan 16;247:371-382. Epub 2019 Jan 16.

Department of Physiology, Federal University of Espírito Santo- UFES, Espírito Santo, Brazil; Department of Pharmacology, University of California, Davis, USA. Electronic address:

Tributyltin (TBT) is an organotin environmental pollutant widely used as an agricultural and wood biocide and in antifouling paints. Countries began restricting TBT use in the 2000s, but their use continues in some agroindustrial processes. We studied the acute effect of TBT on cardiac function by analyzing myocardial contractility and Ca handling. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.053DOI Listing
January 2019

Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance.

Authors:
David O Kennedy

Sports Med 2019 Feb;49(Suppl 1):39-58

Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK.

Subjective alertness and optimal cognitive function, including in terms of attention, spatial/working memory and executive function, are intrinsic to peak performance in many sports. Consumption of a number of plant-derived 'secondary metabolite' phytochemicals can modulate these psychological parameters, although there is a paucity of evidence collected in a sporting context. The structural groups into which these phytochemicals fall-phenolics, terpenes and alkaloids-vary in terms of the ecological roles they play for the plant, their toxicity and the extent to which they exert direct effects on brain function. Read More

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http://dx.doi.org/10.1007/s40279-018-1007-0DOI Listing
February 2019
3 Reads

Drug-Drug Interaction of Ergotamine with a Combination of Darunavir, Abacavir, and Lamivudine Causing a Fatal Vasospastic Ischemia.

Case Rep Emerg Med 2018 19;2018:4107450. Epub 2018 Dec 19.

Université Catholique de Louvain, Place de l'Université 1, 1348 Louvain-la-Neuve, Belgium.

Ergotamine toxicity has become a rare condition which can be caused by, among others, drug-drug interaction. In this work we report a case with vasospastic ischemia induced by the wrongful combination of ergotamine with recently started Antiretroviral Therapy. Clinicians were not aware that patient was self-medicating for years with medication containing ergotamine and caffeine for migraines. Read More

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http://dx.doi.org/10.1155/2018/4107450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313968PMC
December 2018
1 Read

The role of freshwater copepods in the environmental risk assessment of caffeine and propranolol mixtures in the surface water bodies of Spain.

Chemosphere 2019 Apr 18;220:227-236. Epub 2018 Dec 18.

Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, José Beltrán Martínez, 2, 46980, Paterna, Valencia, Spain; University of Gdańsk, Faculty of Biology, Department of Genetics and Biosystematics, Wita Stwosza 59, 80-308, Gdańsk, Poland.

In this study we aimed at assessing: (i) the environmental risk posed by mixtures of caffeine and propranolol to the freshwater ecosystems of Spain; (ii) the sensitivity of freshwater copepod species to the two compounds; (iii) if the toxicity of caffeine and propranolol to freshwater copepods contributes to the environmental risk posed by the two compounds in the freshwater bodies of Spain. The environmental risk was computed as the ratio of MECs (i.e. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.117DOI Listing
April 2019
2 Reads

Review: Trends, Safety, and Recommendations for Caffeine Use in Children and Adolescents.

J Am Acad Child Adolesc Psychiatry 2019 Jan 22;58(1):36-45. Epub 2018 Oct 22.

School of Public Health and Health Professions, University at Buffalo, NY. Electronic address:

Objective: Caffeine use is common in children and adolescents, but the recommendations for safe consumption are based on decades-old data collected exclusively in adults. Increased availability of caffeine-containing products and a concerted marketing effort aimed at children and adolescents, has increased interest in understanding the physiological, behavioral, and psychological effects of caffeine within this population. This manuscript provides a review of the literature concerning trends and safety of ingested caffeine in children and adolescents. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.06.030DOI Listing
January 2019

Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.

Toxicol Lett 2019 Mar 6;302:7-17. Epub 2018 Dec 6.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:

Glucocorticoids play a major factor in fetal maturation and fate decision after birth. We have previously demonstrated that prenatal caffeine exposure (PCE) resulted in adrenal dysplasia. However, its molecular mechanism has not been clarified. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.12.001DOI Listing
March 2019
3 Reads

Experimental data on the degradation of caffeine by photo-electro-fenton using BDD electrodes at pilot plant.

Data Brief 2018 Dec 3;21:1709-1715. Epub 2018 Nov 3.

Escuela de Ingeniería Química, Universidad del Valle, A.A. 23360 Cali, Colombia.

Emerging contaminants (EC) are an imminent risk due to potential toxicity to aquatic ecosystems and human beings. This type of contaminants is found in low concentrations and usually present incomplete or inefficient removal by conventional treatments, which entail its permanence and constant increase. Advanced Oxidation Processes (AOP) are an alternative for the elimination of dangerous and resistant substances in wastewater. Read More

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http://dx.doi.org/10.1016/j.dib.2018.10.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249512PMC
December 2018
1 Read

The clinical toxicology of caffeine: A review and case study.

Authors:
Cyril Willson

Toxicol Rep 2018 3;5:1140-1152. Epub 2018 Nov 3.

EuSci LLC, Gretna, NE, USA.

Caffeine is a widely recognized psychostimulant compound with a long history of consumption by humans. While it has received a significant amount of attention there is still much to be learned with respect to its toxicology in humans, especially in cases of overdose. A review of the history of consumption and the clinical toxicology of caffeine including clinical features, pharmacokinetics, toxicokinetics, a thorough examination of mechanism of action and management/treatment strategies are undertaken. Read More

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http://dx.doi.org/10.1016/j.toxrep.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247400PMC
November 2018
1 Read

Treatment of caffeine toxicity with metoprolol.

Am J Emerg Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Emergency Medicine, Jacobi Medical Center, Bronx, NY, United States of America.

A 27-year-old man presented with an intentional overdose of concentrated caffeine powder that he bought over the internet. The patient received benzodiazepines and ondansetron for symptomatic treatment when he arrived in the Emergency Department (ED). Subsequently, he developed recurrent supraventricular tachycardia in the ED. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757183095
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http://dx.doi.org/10.1016/j.ajem.2018.11.038DOI Listing
November 2018
7 Reads

Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.

Proc Natl Acad Sci U S A 2018 12 3;115(51):E12053-E12062. Epub 2018 Dec 3.

Robert Wood Johnson Medical School Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854;

Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these brains, thereby impeding the assembly of the active trimeric holoenzyme and reducing phosphatase activity. This phosphatase deficiency contributes to the accumulation of hyperphosphorylated α-synuclein, which tends to fibrillize more than unmodified α-synuclein. Read More

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http://dx.doi.org/10.1073/pnas.1813365115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304960PMC
December 2018
2 Reads

Detection of Cutting Agents in Drug-Positive Seized Exhibits within the United States.

J Forensic Sci 2018 Nov 28. Epub 2018 Nov 28.

The Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, 19090.

The following report summarizes a study performed on seized drug exhibits collected in two U.S. states to evaluate the presence and identification of cutting agents. Read More

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http://doi.wiley.com/10.1111/1556-4029.13968
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http://dx.doi.org/10.1111/1556-4029.13968DOI Listing
November 2018
8 Reads

LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses.

J Pharm Biomed Anal 2019 Feb 28;164:430-441. Epub 2018 Oct 28.

School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical Analysis, Toxicology and Food Science, University of São Paulo, Brazil; Ribeirão Preto Medical School, Department of Internal Medicine, University of São Paulo, Brazil. Electronic address:

Drug transporters and CYP enzymes are important sources of pharmacokinetics (PK) variability in drug responses and can cause various pharmacological and toxicological consequences, leading to either toxicity or an insufficient pharmacological effect. In recent years, the cocktail approach was developed to determine in vivo CYP and transporters activities, but these approaches are somewhat limited. We described the development and validation of three sensitive and specific LC-MS/MS assays for the determination of P-gp and major human CYP isoenzyme activities following oral administration of a drug cocktail of subtherapeutic doses (lower than 10 times) of caffeine (CAF), omeprazole (OME), losartan (LOS), midazolam (MDZ), metoprolol (METO) and fexofenadine (FEX) in healthy volunteers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183106
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http://dx.doi.org/10.1016/j.jpba.2018.10.029DOI Listing
February 2019
7 Reads

Comparison of the metabolism of 10 chemicals in human and pig skin explants.

J Appl Toxicol 2019 Feb 21;39(2):385-397. Epub 2018 Oct 21.

Pierre Fabre Dermo-Cosmétique, Toulouse, France.

Skin metabolism is important to consider when assessing local toxicity and/or penetration of chemicals and their metabolites. If human skin supply is limited, pig skin can be used as an alternative. To identify any species differences, we have investigated the metabolism of 10 chemicals in a pig and human skin explant model. Read More

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http://doi.wiley.com/10.1002/jat.3730
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http://dx.doi.org/10.1002/jat.3730DOI Listing
February 2019
67 Reads

Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children.

Nutrients 2018 Oct 18;10(10). Epub 2018 Oct 18.

ToxStrategies, Asheville, NC 28804, USA.

In 2016⁻2017, we conducted and published a systematic review on caffeine safety that set out to determine whether conclusions that were presented in the heavily cited Health Canada assessment, remain supported by more recent data. To that end, we reviewed data from 380 studies published between June 2001 and June 2015, which were identified from an initial batch of over 5000 articles through a stringent search and evaluation process. In the current paper, we use plain language to summarize our process and findings, with the intent of sharing additional context for broader reach to the general public. Read More

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http://www.mdpi.com/2072-6643/10/10/1536
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http://dx.doi.org/10.3390/nu10101536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212940PMC
October 2018
8 Reads

Occurrence of emerging pollutants in estuaries of the Basque Country: Analysis of sources and distribution, and assessment of the environmental risk.

Water Res 2018 12 29;147:152-163. Epub 2018 Sep 29.

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080, Bilbao, Basque Country, Spain; Research Centre for Experimental Marine Biology and Biotechnology (PIE), University of the Basque Country (UPV/EHU), Areatza z/g, 48620, Plentzia, Basque Country, Spain.

In this study, the spatial and temporal-distribution of 41-multiclass organic compounds were assessed in three estuaries of the Basque Country, from winter 2016 to winter 2017 by grab (active) sampling methods and an extra campaign combining both, grab and passive sampling methods. Wastewater treatment plant (WWTP) effluents were also evaluated to assess their impact on the estuaries. Moreover, the physicochemical features (phosphate and nitrate concentrations, pH, etc. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354183074
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http://dx.doi.org/10.1016/j.watres.2018.09.033DOI Listing
December 2018
4 Reads

Identification of putative effectors of the Type IV secretion system from the Wolbachia endosymbiont of Brugia malayi.

PLoS One 2018 27;13(9):e0204736. Epub 2018 Sep 27.

Department of Microbiology, University of Georgia, Athens, GA, United States of America.

Wolbachia is an unculturable, intracellular bacterium that persists within an extremely broad range of arthropod and parasitic nematode hosts, where it is transmitted maternally to offspring via vertical transmission. In the filarial nematode Brugia malayi, a causative agent of human lymphatic filariasis, Wolbachia is an endosymbiont, and its presence is essential for proper nematode development, survival, and pathogenesis. While the elucidation of Wolbachia:nematode interactions that promote the bacterium's intracellular persistence is of great importance, research has been hampered due to the fact that Wolbachia cannot be cultured in the absence of host cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204736PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160203PMC
September 2018
5 Reads

Prenatal caffeine damaged learning and memory in rat offspring mediated by ARs/PKA/CREB/BDNF pathway.

Physiol Res 2018 Dec 11;67(6):975-983. Epub 2018 Sep 11.

Institute for Fetology, First Hospital of Soochow University, Suzhou, China. or

Prenatal exposure to caffeine can cause developmental problems. This study determined chronic influence of prenatal caffeine at relatively higher doses on cognitive functions in the rat offspring. Pregnant Sprague-Dawley rats (4-month-old) were exposed to caffeine (20 mg/kg, twice a day) for whole pregnancy from gestational day 4. Read More

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December 2018
6 Reads

Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes.

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

Department of Anesthesiology, St. Vincentius Clinics, Karlsruhe, Germany.

Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca concentration ([Ca]) after CAS treatment. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01114-18
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http://dx.doi.org/10.1128/AAC.01114-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201063PMC
November 2018
7 Reads

Caffeine Prevents Memory Impairment Induced by Hyperhomocysteinemia.

J Mol Neurosci 2018 Oct 23;66(2):222-228. Epub 2018 Aug 23.

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.

L-Methionine chronic administration leads to impairment of memory. This impairment is due to the increase in the body oxidative stress, which damages neurons and prevents their firing. On the other hand, caffeine has antioxidant and neuroprotective effects that could prevent impairment of memory induced by L-methionine chronic administration. Read More

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http://dx.doi.org/10.1007/s12031-018-1158-3DOI Listing
October 2018
2 Reads

Xanthine derivatives as agents affecting non-dopaminergic neuroprotection in Parkinson`s disease.

Curr Med Chem 2018 Aug 21. Epub 2018 Aug 21.

Laboratory "Drug metabolism and drug toxicity", Department "Pharmacology, Pharmacotherapy and Toxicology", Faculty of Pharmacy, Medical University-Sofia. Bulgaria.

Parkinson's disease (PD) is a neurodegenerative and debilitating disease that affects 1% of elderly population. Patient's motor disability results in an extreme difficulty to deal with daily activities. Conventional treatment is limited to dopamine replacement therapy, which fails to delay disease's progression and is often associated with a number of adverse reactions. Read More

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http://www.eurekaselect.com/164856/article
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http://dx.doi.org/10.2174/0929867325666180821153316DOI Listing
August 2018
10 Reads

Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mRNA and activity and increases caffeine toxicity.

Toxicology 2018 Nov 15;409:129-136. Epub 2018 Aug 15.

EDST-AZM-Center-LBA3B and Faculty of Sciences, Rafic Hariri Campus, Lebanese University, Lebanon. Electronic address:

In animals, cigarette smoke may alter pharmacokinetics by altering activity and expression of ABC drug transporters. We previously demonstrated that cigarette smoke condensate (CSC) impairs activity and expression of several hepatic ABC drug transporters which mediate toxicant efflux. However, CSC effects on efflux transporters are still unknown in Saccharomyces cerevisiae which resists diverse chemical stresses, by inducing pleiotropic drug resistance (PDR) genes among others. Read More

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http://dx.doi.org/10.1016/j.tox.2018.08.005DOI Listing
November 2018
14 Reads

8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity.

Toxicol In Vitro 2018 Dec 9;53:114-120. Epub 2018 Aug 9.

University of Beira Interior, Rua Marquês d'Ávila e Bolama, 6201-001 Covilhã, Portugal. Electronic address:

Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine (PTX) is a novel adenosine antagonist with higher receptor affinity than caffeine. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.08.002DOI Listing
December 2018
3 Reads

Alterations in the Gut Microbiota of Rats Chronically Exposed to Volatilized Cocaine and Its Active Adulterants Caffeine and Phenacetin.

Neurotox Res 2019 Jan 31;35(1):111-121. Epub 2018 Jul 31.

Departamento de Microbiología, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

A role of the gut microbiota in influencing brain function and emotional disorders has been suggested. However, only a few studies have investigated the gut microbiota in the context of drug addiction.Cocaine can be smoked (i. Read More

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http://dx.doi.org/10.1007/s12640-018-9936-9DOI Listing
January 2019
6 Reads

Solid Dispersion of Hesperetin Co-crystals Synergistically Attenuates Hepatic Toxicity of Carbon Tetrachloride Oxidative Stress in Rats.

Curr Drug Deliv 2018 ;15(10):1426-1438

Department of Pharmacology & Toxicology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability.

Objectives: This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP.

Methods: Co-crystals were prepared using citric acid, tartaric acid, caffeine and isonicotinamide (INM) using two methods of solvent evaporation and co-grinding. Read More

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http://dx.doi.org/10.2174/1567201815666180730141556DOI Listing
January 2018
5 Reads

Caffeine: an evidence-based success story in VLBW pharmacotherapy.

Pediatr Res 2018 Sep 9;84(3):333-340. Epub 2018 Jul 9.

Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Apnea of prematurity (AOP) is a common and pervasive problem in very low birth weight infants. Methylxanthines were reported >40 years ago to be an effective therapy and, by the early 2000s, caffeine had become the preferred methylxanthine because of its wide therapeutic index, excellent bioavailability, and longer half-life. A clinical trial to address unresolved questions and toxicity concerns, completed in 2004, confirmed significant benefits of caffeine therapy, including shorter duration of intubation and respiratory support, reduced incidence of chronic lung disease, decreased need for treatment of patent ductus arteriosus, reduced severity of retinopathy of prematurity, and improved motor and visual function. Read More

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http://dx.doi.org/10.1038/s41390-018-0089-6DOI Listing
September 2018
13 Reads

Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation.

Toxicol Lett 2018 Oct 30;295:229-236. Epub 2018 Jun 30.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Our previous in vivo studies showed that prenatal caffeine exposure (PCE) could restrain the development of chondrogenesis, which may delay fetal articular cartilage development and increase susceptibility to osteoarthritis in adults. So, the goal of the current study is to clarify theincreasing susceptibility to adult osteoarthritis in caffeine-exposed female offspring and its'mechanism. Pregnant rats were treated with 120 mg/kg·d caffeine or equal volumes of saline from gestational day (GD) 9 to 20. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.06.1221DOI Listing
October 2018
18 Reads

Emerging contaminants in Brazilian rivers: Occurrence and effects on gene expression in zebrafish (Danio rerio) embryos.

Chemosphere 2018 Oct 7;209:696-704. Epub 2018 Jun 7.

Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados/UFGD, Dourados, MS, Brazil. Electronic address:

Emerging contaminants (ECs) are synthetic or naturally occurring chemicals that are not commonly monitored despite having the potential of entering the environment and causing adverse ecological and/or human health effects. This study aimed to determine whether ECs are present in the surface waters of two rivers in Mato Grosso do Sul State, Brazil, and evaluate the effects of ECs mixtures at environmentally relevant concentrations on zebrafish (Danio rerio) gene expression. ECs concentrations were determined using solid-phase extraction and liquid chromatography-mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.06.046DOI Listing
October 2018
4 Reads

Energy drink and alcohol combination leads to kidney and liver alterations in rats.

Toxicol Appl Pharmacol 2018 09 27;355:138-146. Epub 2018 Jun 27.

Laboratório de Toxicologia (LATOX), Departamento de Análises, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga 2752/605B, 90610-000 Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga 2752/1° andar, 90610-000 Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

The aim of this study was to evaluate the acute toxicity of the association of energy drink and alcohol in male Wistar rats. Animals were treated by oral gavage with 10 ml/kg distilled water (control); 10 ml/kg energy drink (ED10); 3.2 mg/kg caffeine + 40 mg/kg taurine; 2 g/kg alcohol 20%; 2 g/kg alcohol 20% + ED10; and 2 g/kg alcohol 20% + 3. Read More

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http://dx.doi.org/10.1016/j.taap.2018.06.024DOI Listing
September 2018
17 Reads

Prenatal caffeine ingestion induces long-term alterations in scavenger receptor class B type I expression and glucocorticoid synthesis in adult male offspring rat adrenals.

Food Chem Toxicol 2018 Oct 26;120:24-31. Epub 2018 Jun 26.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, Huibei, China. Electronic address:

Caffeine is contained within many drinks and food that are consumed daily. Prenatal caffeine ingestion (PCI) is a risk factor for intrauterine growth retardation (IUGR). We previously observed that PCI inhibits scavenger receptor class B type I (SR-BI)-mediated cholesterol uptake in fetal adrenals, subsequently decreasing glucocorticoid synthesis and inducing IUGR. Read More

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http://dx.doi.org/10.1016/j.fct.2018.06.056DOI Listing
October 2018
5 Reads

Nutritional, chemical and antioxidant/pro-oxidant profiles of silverskin, a coffee roasting by-product.

Food Chem 2018 Nov 21;267:28-35. Epub 2017 Mar 21.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy of University of Porto, R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Coffee silverskin (a coffee roasting by-product) contains high amounts of dietary fibre (49% insoluble and 7% soluble) and protein (19%). Potassium (∼5g/100g), magnesium (2g/100g) and calcium (0.6g/100g) are the major macrominerals. Read More

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http://dx.doi.org/10.1016/j.foodchem.2017.03.106DOI Listing
November 2018
3 Reads

Carcinogenic and neurotoxic risks of acrylamide consumed through caffeinated beverages among the lebanese population.

Chemosphere 2018 Oct 6;208:352-357. Epub 2018 Jun 6.

School of Arts and Sciences, Department of Natural Sciences, Lebanese American University, Byblos, Lebanon. Electronic address:

The present study aims to quantify acrylamide in caffeinated beverages including American coffee, Lebanese coffee, espresso, instant coffee and hot chocolate, and to determine their carcinogenic and neurotoxic risks. A survey was carried for this purpose whereby 78% of the Lebanese population was found to consume at least one type of caffeinated beverages. Gas Chromatography Mass Spectrometry analysis revealed that the average acrylamide level in caffeinated beverages is 29,176 μg/kg sample. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.05.185DOI Listing
October 2018
3 Reads
3.340 Impact Factor

Dose-dependent effects of adenosine antagonists on tacrine-induced tremulous jaw movements.

Eur J Pharmacol 2018 Aug 6;833:364-369. Epub 2018 Jun 6.

California State University, Fullerton Department of Psychology, 800 N. State College Blvd., Fullerton, CA 92831, United States. Electronic address:

The present study examines the effect of three adenosine receptor antagonists on tremulous jaw movements (TJMs), an animal model of tremor. Forty-five rats were pre-treated with one adenosine antagonist: caffeine (0.0, 5. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.06.004DOI Listing
August 2018
2 Reads

Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques.

J Hazard Mater 2018 Sep 17;358:494-502. Epub 2018 May 17.

Masaryk University, Faculty of Science, RECETOX, Kamenice 753/5, 625 00 Brno, Czech Republic. Electronic address:

Growth inhibition of freshwater microalga Pseudokirchneriella subcapitata caused by a waste water treatment plant (WWTP) effluent extract was investigated using an effect directed analysis (EDA) approach. The objective was to identify compounds responsible for the toxicity by combining state-of-the-art sampling, bioanalytical, fractionation and non-target screening techniques. Three fractionation steps of the whole extract were performed and bioactive fractions were analysed with GC (xGC)-MS and LC-HRMS. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2018.05.031DOI Listing
September 2018
15 Reads

Novel insights into TOR signalling in Saccharomyces cerevisiae through Torin2.

Gene 2018 Aug 22;669:15-27. Epub 2018 May 22.

School of Biotechnology, Gautam Buddha University, Greater NOIDA, Gautam Budh Nagar 201312, India. Electronic address:

Target of rapamycin (TOR) regulates cellular homeostasis by coordinating cellular growth pathways in response to different environmental signals. Rapamycin, an allosteric TOR complex 1 (TORC1) inhibitor, has proven to be invaluable for elucidating various aspects of the TOR signalling pathway; however, its applications are limited due to its inability to completely suppress TORC2. In the present study, we examined the effects of a newly discovered potent TOR inhibitor, Torin2, which inhibits both TORC1 and TORC2, on Saccharomyces cerevisiae growth. Read More

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http://dx.doi.org/10.1016/j.gene.2018.05.081DOI Listing
August 2018
8 Reads

Influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy.

Reprod Toxicol 2018 08 22;79:47-56. Epub 2018 May 22.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Epidemiological surveys suggest that adult hypercholesterolemia has an intrauterine origin and exhibits gender differences. Our previous study demonstrated that adult rats with intrauterine growth retardation (IUGR) offspring rats induced by prenatal caffeine exposure (PCE) had a higher serum total cholesterol (TCH) level. In this study, we aimed to analyze the influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.05.005DOI Listing
August 2018
1 Read

Caffeine induces metformin anticancer effect on fibrosarcoma in hamsters.

Eur Rev Med Pharmacol Sci 2018 Apr;22(8):2461-2467

Department of Histology and Embryology, Faculty of Medicine, University of Novi Sad, Novi Sad, Republic of Serbia.

Objective: We investigated the effect of metformin and caffeine on fibrosarcoma in hamsters.

Materials And Methods: 32 Syrian golden hamsters of both sexes, weighing approximately 100 g, were randomly allocated to 3 experimental and 2 control groups, with a minimum of 6 animals per group. 2 x 106 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' back in 4 groups. Read More

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http://dx.doi.org/10.26355/eurrev_201804_14840DOI Listing
April 2018
2 Reads

Caffeine-Related Deaths: Manner of Deaths and Categories at Risk.

Nutrients 2018 May 14;10(5). Epub 2018 May 14.

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Caffeine is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet markets. Read More

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http://dx.doi.org/10.3390/nu10050611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986491PMC
May 2018
2 Reads

Antinociceptive Activity of Methanolic Extract of Leaves: Possible Mechanisms of Action Involved.

Pain Res Manag 2018 4;2018:9536406. Epub 2018 Mar 4.

Department of Veterinary Pre-Clinical Sciences, Faculty of Veterinary Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Methanolic extract of Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using various nociceptive assays. The antinociceptive activity of MECN was (i) tested against capsaicin-, glutamate-, phorbol 12-myristate 13-acetate-, bradykinin-induced nociception model; (ii) prechallenged against selective antagonist of opioid receptor subtypes (-funaltrexamine, naltrindole, and nor-binaltorphimine); (iii) prechallenged against antagonist of nonopioid systems, namely, -noradrenergic (yohimbine), -adrenergic (pindolol), adenosinergic (caffeine), dopaminergic (haloperidol), and cholinergic (atropine) receptors; (iv) prechallenged with inhibitors of various potassium channels (glibenclamide, apamin, charybdotoxin, and tetraethylammonium chloride). Read More

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https://www.hindawi.com/journals/prm/2018/9536406/
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http://dx.doi.org/10.1155/2018/9536406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857305PMC
September 2018
13 Reads

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations.

Crit Rev Food Sci Nutr 2018 Apr 6:1-29. Epub 2018 Apr 6.

d University of Beira Interior (UBI) , Covilhã , Portugal.

Methylated xanthines (methylxanthines) are available from a significant number of different botanical species. They are ordinarily included in daily diet, in many extremely common beverages and foods. Caffeine, theophylline and theobromine are the main methylxanthines available from natural sources. Read More

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http://dx.doi.org/10.1080/10408398.2018.1461607DOI Listing
April 2018
17 Reads

Comparing time-series of chemical concentrations in zebrafish (Danio rerio) embryos/larvae exposed to teratogens with different hydrophobicity; caffeine, sodium valproate, and diethylstilbestrol.

J Toxicol Sci 2018 ;43(4):267-273

School of Veterinary Medicine, Rakuno Gakuen University.

Developmental toxicity is an adverse developmental outcome, i.e., death, malformation, growth retardation, or functional deficiency. Read More

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http://dx.doi.org/10.2131/jts.43.267DOI Listing
August 2018
10 Reads

Occurrence of Functional Molecules in the Flowers of Tea (Camellia sinensis) Plants: Evidence for a Second Resource.

Molecules 2018 Mar 29;23(4). Epub 2018 Mar 29.

Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China.

Tea () is an important crop, and its leaves are used to make the most widely consumed beverage, aside from water. People have been using leaves from tea plants to make teas for a long time. However, less attention has been paid to the flowers of tea plants, which is a waste of an abundant resource. Read More

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http://dx.doi.org/10.3390/molecules23040790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017242PMC
March 2018
13 Reads