1,754 results match your criteria Toxicity Caffeine


Flubendiamide, the first phthalic acid diamide insecticide, impairs neuronal calcium signalling in the honey bee's antennae.

J Insect Physiol 2020 Jul 3:104086. Epub 2020 Jul 3.

INRAE, UR406 Abeilles et Environnement, 84914, Avignon, France; UMT PRADE, Protection des Abeilles dans l'Environnement, 84914, Avignon, France.

Calcium is an important intracellular second messenger involved in several processes such as the transduction of odour signals and neuronal excitability. Despite this critical role, relatively little information is available with respect to the impact of insecticides on the dynamics of intracellular calcium homeostasis in olfactory neurons. For the first time here, physiological stimuli (depolarizing current or pheromone) were shown to elicit calcium transients in peripheral neurons from the honey bee antenna. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2020.104086DOI Listing

[Occurrence and Ecological Risk of Eight Typical PhACs in Surface Water and Its Impact on ].

Huan Jing Ke Xue 2020 May;41(5):2239-2246

Key Laboratory for Integrated Regulation and Resources Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.

The occurrence and risk assessment of eight typical pharmaceutical active compounds (PhACs) in a receiving water body of wastewater treatment plant effluent were investigated. The results showed that the total concentrations of eight PhACs in summer and winter ranged from 27.6 to 226. Read More

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http://dx.doi.org/10.13227/j.hjkx.201910089DOI Listing

Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product -2-butene-1,4-dial on human and rat hepatocytes.

Toxicol Mech Methods 2020 Jun 24:1-10. Epub 2020 Jun 24.

Department of Life Sciences of Faculty of Sciences and Technology, of the University of Coimbra, Coimbra, Portugal.

Coffee is the most popular hot beverage and caffeine is the most used psychoactive drug in the world. Roasting of coffee beans leads to the generation of minute quantities of undesirable compounds, such as furan. It is now thought that the toxicity of furan derives from its processing by CYP450 family of detoxifying enzymes, leading to the formation of -2-butene-1,4-dial (BDA). Read More

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http://dx.doi.org/10.1080/15376516.2020.1780361DOI Listing

Can taste be ergogenic?

Eur J Nutr 2020 May 16. Epub 2020 May 16.

Institute of Coaching and Performance, School of Sport and Wellbeing, University of Central Lancashire, Preston, PR1 2HE, UK.

Taste is a homeostatic function that conveys valuable information, such as energy density, readiness to eat, or toxicity of foodstuffs. Taste is not limited to the oral cavity but affects multiple physiological systems. In this review, we outline the ergogenic potential of substances that impart bitter, sweet, hot and cold tastes administered prior to and during exercise performance and whether the ergogenic benefits of taste are attributable to the placebo effect. Read More

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http://dx.doi.org/10.1007/s00394-020-02274-5DOI Listing

Peracetic Acid vs. Sodium Hypochlorite: Degradation and Transformation of Drugs in Wastewater.

Molecules 2020 May 13;25(10). Epub 2020 May 13.

Department of Chemical Sciences, University of Napoli Federico II, Via Cintia 4, I-80126 Naples, Italy.

Numerous substances from different chemical sectors, from the pharmaceutical industry to the many consumer products available for everyday usage, can find their way into water intended for human consumption and wastewater, and can have adverse effects on the environment and human health. Thus, the disinfection process is an essential stage in water and wastewater treatment plants to destroy pathogenic microorganisms but it can form degradation byproducts. Sodium hypochlorite is the most common disinfectant, but the most important drawback associated with this kind of compound is the generation of toxic disinfection byproducts. Read More

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http://dx.doi.org/10.3390/molecules25102294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287761PMC

High-Dose Insulin Euglycemic Therapy in the Treatment of a Massive Caffeine Overdose.

Chest 2020 May;157(5):e145-e149

Intensive Care Department, Ealing Hospital, London North West University Healthcare NHS Foundation Trust, Southall, United Kingdom.

A 33-year-old woman experienced 90 min of in-hospital cardiac arrest following an intentional overdose of anhydrous caffeine powder. In the face of prolonged and apparently futile resuscitation attempts, high-dose insulin euglycemic therapy was initiated. A loading dose of 1 IU/kg/h of IV insulin resulted in a dramatic improvement in perfusion. Read More

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http://dx.doi.org/10.1016/j.chest.2019.11.030DOI Listing
May 2020
7.483 Impact Factor

Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment.

Toxicol Sci 2020 Jul;176(1):11-33

Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.

Many substances for which consumer safety risk assessments need to be conducted are not associated with specific toxicity modes of action, but rather exhibit nonspecific toxicity leading to cell stress. In this work, a cellular stress panel is described, consisting of 36 biomarkers representing mitochondrial toxicity, cell stress, and cell health, measured predominantly using high content imaging. To evaluate the panel, data were generated for 13 substances at exposures consistent with typical use-case scenarios. Read More

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http://dx.doi.org/10.1093/toxsci/kfaa054DOI Listing

Experimental Exposure Assessment of Ionizable Organic Chemicals in Cell-Based Bioassays.

Chem Res Toxicol 2020 May 19. Epub 2020 May 19.

Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.

Exposure assessment in cell-based bioassays is challenging for ionizable organic chemicals (IOCs), because they are present as more than one chemical species in the bioassay medium. Furthermore, compared to neutral organic chemicals, their binding to medium proteins and lipids is driven by more complex molecular interactions. Total medium concentrations () and/or freely dissolved medium concentrations () were determined for one neutral chemical and 14 IOCs (acids, bases, multifunctional) at concentrations relevant for determination of cytotoxicity and effect. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.0c00067DOI Listing

Electro-Fenton treatment of a complex pharmaceutical mixture: Mineralization efficiency and biodegradability enhancement.

Chemosphere 2020 Aug 3;253:126659. Epub 2020 Apr 3.

Université Paris-Est, Laboratoire Géomatériaux et Environnement, EA 4508, UPEM, 77454, Marne-la-Vallée, France. Electronic address:

Combination of the electro-Fenton process with a post-biological treatment could represent a cost-effective solution for application of electrochemical advanced oxidation processes. The objective of this study was to assess this treatment strategy in the case of a complex pharmaceutical mixture. First, main operating parameters ([Fe] and current) of the electro-Fenton process were optimized. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126659DOI Listing

Case Report Stimulant-Induced Atrial Flutter in a Remote Setting.

J Spec Oper Med 2020 ;20(1):37-39

Atrial flutter and atrial fibrillation are among the most commonly encountered cardiac arrhythmias; however, there is a dearth of clinical trials or case studies regarding its occurrence in the setting of stimulants such as caffeine and nicotine in otherwise healthy young patients. Described here is a case of a 29-year-old physically fit white man without significant past medical history who presented in stable condition complaining only of palpitations. He was found to have atrial flutter without rapid ventricular response on cardiac monitoring, most likely due to concomitant presence of high levels of nicotine and caffeine via chewing tobacco and energy drinks. Read More

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GR/HDAC2/TGFβR1 pathway contributes to prenatal caffeine induced-osteoarthritis susceptibility in male adult offspring rats.

Food Chem Toxicol 2020 Jun 19;140:111279. Epub 2020 Mar 19.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

Prenatal caffeine exposure (PCE) induces developmental toxicity of multi-organ and susceptibility to multi-disease in offspring. However, the effects of PCE on osteoarthritis susceptibility in adult offspring and its intrauterine programming mechanism remain to be further investigated. Here, we found that PCE induced susceptibility to osteoarthritis in male adult offspring rats, which was related to the inhibited function of cartilage matrix synthesis from fetuses to adults. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111279DOI Listing

Alcoholic fermentation as a potential tool for coffee pulp detoxification and reuse: Analysis of phenolic composition and caffeine content by HPLC-DAD-MS/MS.

Food Chem 2020 Jul 15;319:126600. Epub 2020 Mar 15.

QualiSud, Univ Montpellier, CIRAD, Montpellier SupAgro, Univ Avignon, Univ Réunion, Montpellier, France. Electronic address:

High-performance liquid chromatography with diode array (HPLC-DAD) and liquid chromatograph triple quadrupole mass spectrometry (HPLC-MS/MS) were used to characterize raw and fermented coffee pulps in terms of their phenolic composition and caffeine content. The qualitative analysis showed no significant differences between the raw and the fermented pulps. Free hydroxycinnamic acids (HAs) were mainly chlorogenic acids, with 5-caffeoylquinic acid as the major compound. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.126600DOI Listing

Removal of 17α-ethinylestradiol and caffeine from wastewater by UASB-Fenton coupled system.

Environ Technol 2020 Mar 18:1-12. Epub 2020 Mar 18.

El Colegio de la Frontera Sur, Tapachula, Chiapas, México.

In aquatic systems, some substances considered as endocrine disruptors have been detected, which can be due to their incomplete elimination in wastewater treatment plants (WWTPs) and inadequate disposal of pharmaceuticals. Among these contaminants are 17α-ethinylestradiol (EE2) and caffeine (CAF). Moreover, it has been reported that this kind of contaminants may provoke different adverse effects in many aquatic organisms. Read More

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http://dx.doi.org/10.1080/09593330.2020.1740799DOI Listing

Treatment of ibuprofen intoxication with charcoal haemoperfusion in two dogs.

N Z Vet J 2020 Jul 8;68(4):255-260. Epub 2020 Apr 8.

Small Animal Teaching Hospital, University of Florida, Gainesville, FL, USA.

Two dogs presented separately to the Small Animal Hospital, University of Florida (Gainsville, FL, USA) for ingestion of ibuprofen. The first dog ingested 561.8 mg/kg ibuprofen in addition to paracetamol and caffeine and vomited prior to admission. Read More

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http://dx.doi.org/10.1080/00480169.2020.1740111DOI Listing

Physiological and biochemical responses of tea seedlings (Camellia sinensis) to simulated acid rain conditions.

Ecotoxicol Environ Saf 2020 Apr 10;192:110315. Epub 2020 Feb 10.

Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan, 410128, China; National Research Center of Engineering & Technology for Utilization of Functional Ingredients from Botanicals, Collaborative Innovation Center of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, Hunan, 410128, China. Electronic address:

Tea (Camellia sinensis), widely planted in the south of China, and often exposed to acid rain. However, research concerning the impacts of acid rain on physiology and biochemistry of tea plants is still scarce. In this study, we investigated the influence of simulated acid rain (SAR) on plant height, root length, photosynthetic pigment, Fv/Fm, proline, malondialdehyde, antioxidant enzyme activity, total nitrogen, caffeine, catechins, and free amino acids. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110315DOI Listing

Caffeine Intoxication in Pregnancy; a case Report.

Arch Acad Emerg Med 2019 16;7(1):e67. Epub 2019 Nov 16.

Emergency Department, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Although fatalities due to caffeine intoxication are uncommon, a caffeine overdose may cause profound toxicity, resulting in tachycardia, arrhythmia, convulsions, vomiting, coma, and possibly death. In particular, high caffeine consumption while pregnant can cause increased fetal catecholamine levels, which could lead to increased fetal heart rate and placental vasoconstriction and impair fetal oxygenation. Therefore, caffeine intoxication in pregnant women should be treated immediately. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942917PMC
November 2019

Critical study of crop-derived biochars for soil amendment and pharmaceutical ecotoxicity reduction.

Chemosphere 2020 Jun 22;248:125976. Epub 2020 Jan 22.

Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Ul. Wita Stwosza 63, 80-308, Gdańsk, Poland.

In this study, biochars (BCs) produced from crops (straw and seeds) were tested for the applicability as additive to soils. The effect on pH, water capacity and cation exchange capacity of soil were tested. The ability for the sorption of pharmaceuticals (beta-blockers, anti-inflammatory drugs, sulfonamides, 17α-ethinylestradiol, carbamazepine, caffeine) using the batch sorption test was performed, and the effect of water pH was investigated. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.125976DOI Listing

Phytochemical Analysis and Toxicity Assessment of Artichoke By-product Extract.

Pak J Biol Sci 2020 Jan;23(1):81-91

Background And Objective: Egypt produced 236,314 t of artichoke in 2016, which produce a huge amount of useless by-product, which can be used as cheaper source for many active compounds can be applied for some medical application. The objective of this study was to assess the toxicity of the artichoke by-product extract through its effect on rats' kidney, brain and liver biomarkers.

Materials And Methods: Chemical composition of artichoke by-product (crude protein, crude fiber, crude fat and minerals) was determined. Read More

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http://dx.doi.org/10.3923/pjbs.2020.81.91DOI Listing
January 2020

Ecotoxicological study of six drugs in Aliivibrio fischeri, Daphnia magna and Raphidocelis subcapitata.

Environ Sci Pollut Res Int 2020 Mar 11;27(9):9891-9900. Epub 2020 Jan 11.

Universidad San Jorge, Campus Universitario, Autovia A23 km 299, 50830, Villanueva de Gállego, Zaragoza, Spain.

The presence of drugs in the environment is an emerging issue in the scientific community. It has been shown that these substances are active chemicals that consequently affect aquatic organisms and, finally, humans as end users. To evaluate the toxicity of these compounds and how they affect the environment, it is important to perform systematic ecotoxicological and physicochemical studies. Read More

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http://dx.doi.org/10.1007/s11356-019-07592-8DOI Listing

A Toxicological Evaluation of Methylliberine (Dynamine®).

J Toxicol 2019 27;2019:4981420. Epub 2019 Oct 27.

Toxi-Coop Zrt., Magyar Jakobinusok tere 4/B, H-1122 Budapest, Hungary.

Methylliberine (CAS 51168-26-4), a methoxiuric acid, is a caffeine metabolite present at low levels in various plants; however, very little has been published regarding this compound and we could find no toxicological data in the public domain. Therefore, we undertook the toxicological investigation of a pure, synthetic form of methylliberine in order to evaluate its potential health hazards as a food ingredient. A (1) bacterial reverse mutation test, (2) in vitro mammalian chromosomal aberration test, (3) in vivo mammalian micronucleus test, and (4) 90-day repeated-dose oral toxicity study in rats with a 28-day recovery period were conducted. Read More

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http://dx.doi.org/10.1155/2019/4981420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930730PMC
October 2019

Effect of and leaf extracts on selected biochemical indices in model of neurotoxicity.

Drug Chem Toxicol 2020 Jan 3:1-10. Epub 2020 Jan 3.

Functional Foods and Nutraceuticals Unit of Biochemistry Department, Federal University of Technology, Akure, Nigeria.

Aluminum (Al)-induced toxicity in fruit fly ( is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extracts of and leaves on Al-induced toxicity in wild type The flies were exposed to diets containing 40 mM AlCl, and the alkaloid extracts (0. Read More

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http://dx.doi.org/10.1080/01480545.2019.1708377DOI Listing
January 2020

Ny-Ålesund-oriented organic pollutants in sewage effluent and receiving seawater in the Arctic region of Kongsfjorden.

Environ Pollut 2020 Mar 13;258:113792. Epub 2019 Dec 13.

Graduate School of FEED of Eco-Friendly Offshore Structure, Changwon National University, Changwon, Gyeongsangnamdo, 51140, South Korea; School of Civil, Environmental and Chemical Engineering, Changwon National University, Changwon, Gyeongsangnamdo, 51140, South Korea. Electronic address:

Ny-Ålesund, one of four permanent settlements on Spitsbergen in Svalbard, is a research town that includes scientific institutes from many countries. Because of daily-used chemicals (e.g. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113792DOI Listing

Exogenous indole acetic acid alleviates Cd toxicity in tea (Camellia sinensis).

Ecotoxicol Environ Saf 2020 Mar 23;190:110090. Epub 2019 Dec 23.

Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan, 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Collaborative Innovation Centre of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, Hunan, 410128, China. Electronic address:

Cadmium (Cd), a toxic heavy metal, restrains the growth and development of plants and threatens global food safety. Many studies on the alleviation of heavy metal toxicity by exogenous phytohormones have emerged, but reports on tea (Camellia sinensis) are still scarce. In this study, the effects of indole acetic acid (IAA) (2 μM and 10 μM) on Cd uptake and on the physiological and biochemical characteristics of the 'Xiangfeicui' tea cultivar were investigated for the first time. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.110090DOI Listing

Subchondral bone dysplasia mediates susceptibility to osteoarthritis in female adult offspring rats induced by prenatal caffeine exposure.

Toxicol Lett 2020 Mar 23;321:122-130. Epub 2019 Dec 23.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Our previous studies confirmed that prenatal caffeine exposure (PCE) could induce susceptibility to osteoarthritis in adult offspring rats due to poor chondrocyte differentiation, but its mechanism remains to be further investigated. This study aimed to explore whether subchondral bone dysplasia mediates susceptibility to osteoarthritis in adult offspring rats induced by PCE. Pregnant Wistar rats were treated with caffeine (120 mg/kg. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.12.026DOI Listing

Occurrence, fate, persistence and remediation of caffeine: a review.

Environ Sci Pollut Res Int 2019 Dec 7. Epub 2019 Dec 7.

Department of Botany, Indira Mahavidyalaya Kalamb, Dist. Yavatmal, Maharashtra, 445401, India.

Pharmaceutical and personal care products (PPCPs) have gained attention in recent years due to their continuous discharge in natural waters. Their persistence in the environment has impacted flora, fauna and human being worldwide. One of the most common PPCPs is caffeine (1, 3, 7-trimethylxanthine) which acts as a stimulant to the central nervous system in humans and is found in nature in about 60 plant species, especially in coffee, tea and cacao plants. Read More

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http://dx.doi.org/10.1007/s11356-019-06998-8DOI Listing
December 2019
4 Reads

Acute intentional caffeine overdose treated preemptively with hemodialysis.

Am J Emerg Med 2020 03 15;38(3):692.e1-692.e3. Epub 2019 Nov 15.

Department of Emergency Medicine, Jefferson Northeast Hospital, United States.

Caffeine is the most commonly used central nervous system stimulant. While it has a high LD (150-200 mg/kg), when ingested in significant quantity, caffeine can lead to severe and even lethal side effects. Manifestation of toxicity include tachyarrhythmias, seizures, and metabolic derangements which can eventually lead to cardiovascular collapse and death. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.09.018DOI Listing

Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination.

Environ Sci Pollut Res Int 2020 Jan 25;27(2):1941-1955. Epub 2019 Nov 25.

Research Unit of Analysis and Process Applied to the Environment-APAE UR17ES32, Higher Institute of Applied Sciences and Technology Mahdia "ISSAT", University of Monastir, 5100, Mahdia, Tunisia.

In the present study, the occurrence of 40 pharmaceuticals belonging to several therapeutic groups was investigated for the first time in hospital effluent, wastewater treatment plant influent and effluent, and seawater in Mahdia, Tunisia. Forty-six samples were collected within a 6-month sampling period. Pharmaceuticals were analyzed using solid-phase extraction followed by ultra-performance liquid chromatography-triple quadrupole mass spectrometry. Read More

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http://dx.doi.org/10.1007/s11356-019-06866-5DOI Listing
January 2020
2.828 Impact Factor

Characterization of the Nairobi River catchment impact zone and occurrence of pharmaceuticals: Implications for an impact zone inclusive environmental risk assessment.

Sci Total Environ 2020 Feb 2;703:134925. Epub 2019 Nov 2.

School of Geography, Earth and Environmental Sciences, Plymouth University, Plymouth PL4 8AA, UK. Electronic address:

The largely uncontrolled release of active pharmaceuticals ingredients (APIs) within untreated wastewater discharged to waterbodies, associated with many rapidly urbanising centres is of growing concern owing to potential antimicrobial resistance, endocrine disruption and potential toxicity. A sampling campaign has been undertaken to assess the source, occurrence, magnitude and risk associated with APIs and other chemicals within the Nairobi/Athi river basin, in Kenya, East Africa. The catchment showed an extensive downstream impact zone estimated to extend 75 km, mostly, but not exclusively, derived from the direct discharge of untreated wastewater from the urban centre of Nairobi city. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.134925DOI Listing
February 2020

Caffeine Therapy in Preterm Infants: The Dose (and Timing) Make the Medicine.

Neonatal Netw 2019 Nov;38(6):365-374

Caffeine is one of the most commonly utilized medications in the NICU. In preterm infants, short-term and long-term pulmonary and neurodevelopmental benefits of therapy are well documented in the literature. While robust evidence supports the use of standard doses of caffeine for apnea of prematurity or to facilitate successful extubation, much remains unknown regarding the boundaries of efficacy and safety for this common therapeutic agent. Read More

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http://dx.doi.org/10.1891/0730-0832.38.6.365DOI Listing
November 2019

Comparison of the metabolism of 10 cosmetics-relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants.

J Appl Toxicol 2020 Feb 7;40(2):313-326. Epub 2019 Nov 7.

L'Oreal, Aulnay-Sous-Bois, France.

An understanding of the bioavailability of topically applied cosmetics ingredients is key to predicting their local skin and systemic toxicity and making a safety assessment. We investigated whether short-term incubations with S9 from the reconstructed epidermal skin model, EpiSkin™, would give an indication of the rate of chemical metabolism and produce similar metabolites to those formed in incubations with human skin explants. Both have advantages: EpiSkin™ S9 is a higher-throughput assay, while the human skin explant model represents a longer incubation duration (24 hours) model integrating cutaneous distribution with metabolite formation. Read More

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http://dx.doi.org/10.1002/jat.3905DOI Listing
February 2020
1 Read

Construction of DOX/APC co-loaded BiOI@CuS NPs for safe and highly effective CT imaging and chemo-photothermal therapy of lung cancer.

J Mater Chem B 2019 12 25;7(45):7176-7183. Epub 2019 Oct 25.

School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

Recently, a variety of nanoparticles have been widely used as imaging agents or carriers for the diagnosis and therapy of lung cancer. However, their poor imaging effect, high toxicity, pro-inflammatory effect and ineffective treatment are still a great challenge. In this work, we reported a novel kind of BiOI@CuS nanoparticle to achieve safe and effective therapy of lung cancer by co-loading hydrochloric acid doxorubicin (DOX) and aspirin phenacetin and caffeine (APC). Read More

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http://dx.doi.org/10.1039/c9tb01874cDOI Listing
December 2019

extract provides increased resistance against oxidative stress and protection against Amyloid beta-induced toxicity compared to caffeine in .

Nutr Neurosci 2019 Oct 9:1-13. Epub 2019 Oct 9.

Departamento de Biologia Celular e Genética, Universidade Federal do Rio Grande do Norte , Natal , Brazil.

is a plant from South America, used to prepare a tea-like beverage rich in caffeine and polyphenols with antioxidant proprieties. Caffeine consumption is associated with a lower risk of age-associated neuropathologies, besides several extracts that have antioxidant proprieties are known to be neuroprotective, and oxidative stress strongly correlates with Aβ-toxicity. This study aims to investigate the neuroprotective effects of the hydroalcoholic extract (IPHE) and to evaluate if caffeine agent present in IPHE exerts neuroprotective effects in an amyloid beta-peptide (Aβ)-induced toxicity in The wild-type and CL2006 worms were treated with IPHE (2 and 4 mg/mL) or caffeine (200 and 400 μM) since larval stage 1 (L1) until they achieved the required age for each assay. Read More

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http://dx.doi.org/10.1080/1028415X.2019.1671694DOI Listing
October 2019
2 Reads
2.114 Impact Factor

Detrimental Effects of an Inhaled Phosphodiesterase-4 Inhibitor on Lung Inflammation in Ventilated Preterm Lambs Exposed to Chorioamnionitis Are Dose Dependent.

J Aerosol Med Pulm Drug Deliv 2019 12 1;32(6):396-404. Epub 2019 Oct 1.

University Children's Hospital Würzburg, University of Würzburg, Würzburg, Germany.

Treatment of bronchopulmonary dysplasia in preterm infants is challenging due to its multifactorial origin. In rodent models of neonatal lung injury, selective inhibition of phosphodiesterase 4 (PDE4) has been shown to exert anti-inflammatory properties in the lung. We hypothesized that GSK256066, a highly selective, inhalable PDE4 inhibitor, would have beneficial effects on lung injury and inflammation in a triple hit lamb model of Ureaplasma parvum (UP)-induced chorioamnionitis, prematurity, and mechanical ventilation. Read More

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http://dx.doi.org/10.1089/jamp.2019.1528DOI Listing
December 2019
1 Read

Serum metabolic profile characteristics of offspring rats before and after birth caused by prenatal caffeine exposure.

Toxicology 2019 11 27;427:152302. Epub 2019 Sep 27.

Department of Pharmacology, Wuhan University School of Basic Medical Science, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:

Epidemiological investigations have confirmed that prenatal caffeine intake could increase the incidence rate of intrauterine growth retardation (IUGR) and multiple diseases after birth. Based on liquid chromatography-mass spectrometry, we analyzed serum metabolic profiles of offspring rats before and after birth in IUGR model induced by prenatal caffeine exposure (PCE). We discovered that differential metabolites in PCE fetuses mainly manifested as amino acids and lipid metabolism. Read More

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http://dx.doi.org/10.1016/j.tox.2019.152302DOI Listing
November 2019
3 Reads
3.621 Impact Factor

Beware Energy Drinks: A Case of a Toxic Triad Syndrome in a Diabetic Patient With Nonalcoholic Fatty Liver Disease.

Authors:
Gabriel I Uwaifo

Am J Med Sci 2019 10 2;358(4):304-311. Epub 2019 Aug 2.

Department of Endocrinology, Diabetes, Metabolism, and Weight Management, Ochsner Medical Center, New Orleans, Louisiana. Electronic address:

Energy drinks are widely used and very popular. They are touted as "harmless" energy boosters for use in professional, recreational and domestic settings. They are typically high in monosaccharides, and caffeine with other assorted products like ginseng. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.07.015DOI Listing
October 2019
2 Reads

Interaction of cigarette smoke condensate and some of its components with chlorpromazine toxicity on .

Drug Chem Toxicol 2019 Sep 13:1-11. Epub 2019 Sep 13.

EDST-AZM-center-LBA3B - Tripoli and Faculty of Sciences, Lebanese University , Beirut , Lebanon.

Chlorpromazine (CPZ) is an antipsychotic phenothiazine which is still commonly prescribed though it causes idiosyncratic toxicity such as cholestasis. CPZ toxicity mechanisms involve oxidative stress among others. Cigarette smoke (CS) causes deleterious effects through diverse mechanisms such as oxidative stress. Read More

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http://dx.doi.org/10.1080/01480545.2019.1659809DOI Listing
September 2019
1 Read
1.098 Impact Factor

Anthropogenic contaminants of high concern: Existence in water resources and their adverse effects.

Sci Total Environ 2019 Nov 6;690:1068-1088. Epub 2019 Jul 6.

Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, CP 64849 Monterrey, N.L., Mexico. Electronic address:

Existence of anthropogenic contaminants (ACs) in different environmental matrices is a serious and unresolved concern. For instance, ACs from different sectors, such as industrial, agricultural, and pharmaceutical, are found in water bodies with considerable endocrine disruptors potency and can damage the biotic components of the environment. The continuous ACs exposure can cause cellular toxicity, apoptosis, genotoxicity, and alterations in sex ratios in human beings. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.07.052DOI Listing
November 2019
4 Reads

Antinociceptive Activity of Petroleum Ether Fraction of Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels.

Biomed Res Int 2019 5;2019:6593125. Epub 2019 Aug 5.

Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.

Methanolic extract of Lindau leaves (MECN) has been reported to exert antinociceptive activity. The present study aimed to elucidate the possible antinociceptive mechanisms of a lipid-soluble fraction of MECN, which was obtained after sequential extraction in petroleum ether. The petroleum ether fraction of (PECN), administered orally to mice, was (i) subjected to capsaicin-, glutamate-, phorbol 12-myristate 13-acetate-, bradykinin-induced nociception model; (ii) prechallenged (intraperitoneal (i. Read More

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http://dx.doi.org/10.1155/2019/6593125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699298PMC
January 2020

Distribution and Chemical Analysis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environmental Systems: A Review.

Int J Environ Res Public Health 2019 08 21;16(17). Epub 2019 Aug 21.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice 5700, South Africa.

PPCPs are found almost everywhere in the environment especially at an alarming rate and at very low concentration in the aquatic systems. Many methods-including pressurized hot water extraction (PHWE), pressurized liquid extraction (PLE), ultrasound-assisted extraction (UAE), and micro-assisted extraction (MAE)-have been employed for their extraction from both surface waters and biota. Solid-phase extraction (SPE) proved to be the best extraction method for these polar, non-volatile, and thermally unstable compounds in water. Read More

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http://dx.doi.org/10.3390/ijerph16173026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747491PMC
August 2019
1 Read

The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson's Disease (PD).

Cells 2019 08 16;8(8). Epub 2019 Aug 16.

Department of Research, National Neuroscience Institute, Singapore 308433, Singapore.

Accumulative evidence indicated that the pathologically accumulated metal ions (iron species and Mn) and abnormally up-regulated monoamine oxidase B (MAOB) activity induced oxidation of endogenous dopamine (DA) can lead to mitochondria impairment, lysosome dysfunction, proteasome inhibition, and selective DA neuron vulnerability, which is implicated in the pathogenesis of Parkinson's disease (PD). The DA oxidation can generate deleterious reactive oxygen species (ROS) and highly reactive DA quinones (DAQ) to induce DA-related toxicity, which can be alleviated by DA oxidation suppressors, ROS scavengers, DAQ quenchers, and MAOB inhibitors. On the other hand, the nuclear factor erythroid 2-related factor 2 (Nrf2)-Keap1 and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) anti-oxidative and proliferative signaling pathways play roles in anti-oxidative cell defense and mitochondria biogenesis, which is implicated in DA neuron protections. Read More

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http://dx.doi.org/10.3390/cells8080911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721683PMC
August 2019
4 Reads

Prioritizing chemicals of ecological concern in Great Lakes tributaries using high-throughput screening data and adverse outcome pathways.

Sci Total Environ 2019 Oct 5;686:995-1009. Epub 2019 Jun 5.

U.S. Geological Survey, Boise, ID 83702, United States.

Chemical monitoring data were collected in surface waters from 57 Great Lakes tributaries from 2010 to 13 to identify chemicals of potential biological relevance and sites at which these chemicals occur. Traditional water-quality benchmarks for aquatic life based on in vivo toxicity data were available for 34 of 67 evaluated chemicals. To expand evaluation of potential biological effects, measured chemical concentrations were compared to chemical-specific biological activities determined in high-throughput (ToxCast) in vitro assays. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.05.457DOI Listing
October 2019
2 Reads

Nutraceutical Potential of Diet Drinks: A Critical Review on Components, Health Effects, and Consumer Safety.

J Am Coll Nutr 2020 Mar-Apr;39(3):272-286. Epub 2019 Jul 25.

Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara, Punjab, India.

The purpose of this review paper was to explore the components and their respective health effects and safety aspects regarding the consumption of diet drinks (DDs). A wide variety of the relevant publications (published before 2018) were identified through searching electronic databases (ScienceDirect, PubMed, SciELO, Google Scholar, Springer Link, and ResearchGate) on the basis of different keywords such as diet drink, market status, consumption pattern, composition, health effects, and regulations related to DDs. After the search of suitable literature, 139 papers were screened and reviewed. Read More

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http://dx.doi.org/10.1080/07315724.2019.1642811DOI Listing
July 2019
4 Reads
1.676 Impact Factor

Prenatal caffeine exposure induces liver developmental dysfunction in offspring rats.

J Endocrinol 2019 07 26;242(3):211-226. Epub 2019 Jul 26.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, China.

We previously showed that prenatal caffeine exposure (PCE) induces intrauterine growth retardation (IUGR) and high susceptibility to nonalcoholic fatty liver disease in offspring rats, and the underlying mechanisms are associated with fetal overexposure to maternal glucocorticoids. Herein, we aimed to verify whether PCE disrupts liver development before and after birth and explore its possible programming mechanism. In vivo, reduced fetal weights and increased IUGR rates were accompanied by fetal liver developmental dysfunction in PCE rats. Read More

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http://dx.doi.org/10.1530/JOE-19-0066DOI Listing
July 2019
3 Reads

Response of the Green Alga to the DNA Damaging Agent Zeocin.

Cells 2019 07 17;8(7). Epub 2019 Jul 17.

Laboratory of Cell Cycles of Algae, Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, 37981 Třeboň, Czech Republic.

DNA damage is a ubiquitous threat endangering DNA integrity in all living organisms. Responses to DNA damage include, among others, induction of DNA repair and blocking of cell cycle progression in order to prevent transmission of damaged DNA to daughter cells. Here, we tested the effect of the antibiotic zeocin, inducing double stranded DNA breaks, on the cell cycle of synchronized cultures of the green alga . Read More

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http://dx.doi.org/10.3390/cells8070735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678277PMC

Decreased H3K9ac level of KLF4 mediates podocyte developmental toxicity induced by prenatal caffeine exposure in male offspring rats.

Toxicol Lett 2019 Oct 12;314:63-74. Epub 2019 Jul 12.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:

This study aimed to verify the toxic effects of prenatal caffeine exposure (PCE) on the podocyte development in male offspring, and to explore the underlying intrauterine programming mechanisms. The pregnant rats were administered with caffeine (30 to 120 mg/kg⋅d) during gestational day (GD) 9 to 20. The male fetus on GD20 and the offspring at postnatal week (PW) 6 and PW28 were sacrificed. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.07.011DOI Listing
October 2019
3 Reads

Pre-clinical and cellular toxicity evaluation of 7-methylxanthine: an investigational drug for the treatment of myopia.

Drug Chem Toxicol 2019 Jul 12:1-10. Epub 2019 Jul 12.

a Department of Pharmaceutical Sciences , Guru Nanak Dev University , Amritsar , India.

The present study entails the toxicity evaluation of 7-methyl xanthine (7-MX), first of its kind molecule found effective in phase II clinical trials for the treatment of myopia, in comparison to other clinically used xanthines i.e., caffeine and theobromine. Read More

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http://dx.doi.org/10.1080/01480545.2019.1635615DOI Listing
July 2019
10 Reads

A health risk for consumers: the presence of adulterated food supplements in the Netherlands.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Sep 11;36(9):1273-1288. Epub 2019 Jul 11.

Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research , Wageningen , The Netherlands.

The use of food supplements is increasing. They are marketed as beneficial for health, well-being, physical or mental condition and performance, or to prevent diseases. Producers add synthetic compounds or illicit herbal material to food supplements to claim desired effects. Read More

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http://dx.doi.org/10.1080/19440049.2019.1633020DOI Listing
September 2019
5 Reads

Chironomus sancticaroli (Diptera, Chironomidae) as a Sensitive Test Species: Can We Rely on Its Use After Repeated Generations, Under Laboratory Conditions?

Bull Environ Contam Toxicol 2019 Aug 17;103(2):213-217. Epub 2019 Jun 17.

Departamento de Hidráulica E Saneamento, Escola de Engenharia de São Carlos (EESC), Universidade de São Paulo - USP, C.P. 359, São Carlos, SP, CEP 13566-590, Brazil.

In ecotoxicological assays, previously selected and standardized organism tests are exposed to an environmental sample. Some species of the Chironomus genus have been extensively used in ecotoxicological assays. Among these, Chironomus tentans is usually utilized in the USA and Chironomus sancticaroli in Brazil. Read More

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http://dx.doi.org/10.1007/s00128-019-02644-8DOI Listing
August 2019
3 Reads

Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells.

J Toxicol Sci 2019 ;44(6):415-424

School of Pharmacy, Sungkyunkwan University, Korea.

Polyhexamethylene guanidine phosphate (PHMG-p) is an active ingredient of humidifier disinfectants and causes severe lung injury resulting in pulmonary fibrosis. Current evidence indicates that pulmonary fibrosis is initiated as a result of epithelial damage, which can lead to an inflammatory response and fibrotic cell infiltration; however, the toxic mechanism of PHMG-p on the epithelium is still unknown. In this study, the toxic response of PHMG-p on human lung epithelial cells was evaluated, and its mechanisms associated with reactive oxygen species (ROS), DNA damage, and its relationship with p53 activation were investigated. Read More

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http://dx.doi.org/10.2131/jts.44.415DOI Listing
July 2019
5 Reads

The GC-IGF1 axis-mediated testicular dysplasia caused by prenatal caffeine exposure.

J Endocrinol 2019 07;242(1):M17-M32

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, China.

Prenatal caffeine exposure (PCE) can induce testicular developmental toxicity. Here, we aimed to explore the underlying mechanism of this process in reference to its intrauterine origin. Pregnant rats were intragastrically administrated caffeine (30 and 120 mg/kg/day) from gestational days 9 to 20. Read More

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http://dx.doi.org/10.1530/JOE-18-0684DOI Listing
July 2019
25 Reads
3.718 Impact Factor