J Addict Med 2022 Feb 14. Epub 2022 Feb 14.
Psychiatry Residency Spokane, Providence Sacred Heart Medical Center, Spokane, WA, USA (HDB, AGB); College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, Yakima, WA, USA (MMM); Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University Spokane, WA, USA (MFP); Providence Medical Research Center, Providence Health Care, Spokane, WA, USA (EJC).
The botanical product kratom produces opioid-like effects at high doses and is sometimes used for opioid replacement by individuals with opioid use disorder. Mitragynine, a major alkaloid contained in kratom leaves, has been shown to inhibit multiple cytochromes P450 (CYPs) in vitro, including CYP2D6 and CYP3A. As such, kratom may precipitate pharmacokinetic drug interactions when co-consumed with certain medications. Read More