2,132 results match your criteria Toxicity Beta-blocker


In Vitro Toxicological Profile of Labetalol-Folic Acid/Folate Co-Administration in H9c2(2-1) and HepaRG Cells.

Medicina (Kaunas) 2022 Jun 10;58(6). Epub 2022 Jun 10.

Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No.2, 300041 Timisoara, Romania.

The consumption of dietary supplements has increased over the last decades among pregnant women, becoming an efficient resource of micronutrients able to satisfy their nutritional needs during pregnancy. Furthermore, gestational drug administration might be necessary to treat several pregnancy complications such as hypertension. Folic acid (FA) and folate (FT) supplementation is highly recommended by clinicians during pregnancy, especially for preventing neural tube birth defects, while labetalol (LB) is a β-blocker commonly administered as a safe option for the treatment of pregnancy-related hypertension. Read More

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Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity.

J Hazard Mater 2022 05 16;430:128499. Epub 2022 Feb 16.

School of Energy and Environment, City University of Hong Kong, Hong Kong Special Administrative Region of China.

The partitioning between phospholipids/proteins and water can be used to predict the bioaccumulation potential of chemicals with better accuracy compared with n-octanol-water partition coefficient. However, such partitioning is poorly understood for chiral chemicals, many of which exhibit differential bioaccumulation and toxicity potential between enantiomers. In this study, the enantiospecific liposome-water and bovine serum albumin (BSA)-water partition coefficients (Klip/w and KBSA/w, determined at 25 ℃ and 37 ℃, respectively) were measured by equilibrium dialysis for α-, β-, and γ-hexabromocyclododecane (HBCD) and three β-blockers (propranolol, metoprolol, and sotalol). Read More

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'Namdokmai' Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Model of Alzheimer's Amyloidosis.

Pharmaceuticals (Basel) 2022 May 11;15(5). Epub 2022 May 11.

Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand.

Alzheimer's disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including 'Phulae', 'Pattavia', 'Khaekdum', 'Khaeknuan', 'Monthong', 'Chanee', 'Kimju', 'Keenok', 'Kaew' and 'Namdokmai' were screened for their inhibitory activities against the key enzymes, cholinesterases and β-secretase (BACE-1), involved in AD pathogenesis. Read More

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Treatment of critical aluminum phosphide (rice tablet) poisoning with high-dose insulin: a case report.

J Med Case Rep 2022 May 17;16(1):192. Epub 2022 May 17.

Department of Internal Medicine, Emam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran.

Background: Aluminum phosphide (rice tablet) is a highly efficient agent for preserving grains against rodents and insects. It accounts for a large number of poisoning cases. Aluminum phosphide poisoning has a high mortality rate of about 90%, and to date, no antidote is available. Read More

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Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats.

Mol Neurobiol 2022 Jul 12;59(7):4368-4383. Epub 2022 May 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt.

Telmisartan (TEL) is an angiotensin II type 1 receptor blocker and a partial activator of peroxisome proliferator-activated receptor-gamma (PPARγ), which regulates inflammatory and apoptotic pathways. Increasing evidence has demonstrated the PPARγ agonistic property of TEL in several brain disorders. This study aims to explore the neuroprotective impact of TEL in 3-nitropropionic acid (3-NP)-induced neurotoxicity in rats. Read More

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Potential role of carvedilol in intestinal toxicity through NF-κB/iNOS/COX-2/TNF-α inflammatory signaling pathway in rats.

Immunopharmacol Immunotoxicol 2022 May 4:1-8. Epub 2022 May 4.

Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt.

Background: The increased use of indomethacin (IND) is associated with gastrointestinal injury. This research aims to investigate the effects of a beta-blocker, carvedilol (CAR) on a rat model of IND-induced acute intestinal damage and clarify the probable underlying protective mechanisms.

Materials And Methods: Twenty-four male Wistar rats were divided into four groups. Read More

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Corallodiscus flabellata B. L. Burtt extract and isonuomioside A ameliorate Aβ-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway.

Phytomedicine 2022 Jul 22;101:154114. Epub 2022 Apr 22.

College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, China. Electronic address:

Background: Corallodiscus flabellata B. L. Burtt, a traditional Chinese folk medicine used for amnesia, can significantly improve brain injury; however, its active components and underlying mechanism of action remain unclear. Read More

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SUPPLEMENT ARTICLE: A Novel Drug Delivery Method: Retrometabolic Drug Design.

J Drugs Dermatol 2022 Apr;21(4):s5-s10

Soft drugs, a class of retrometabolic drug design, contain a metabolically sensitive moiety that promotes rapid metabolism to inactive metabolites after exerting activity at its target site. The goal of soft drugs is to reduce systemic toxicity while enhancing local efficacy. Soft drugs have been approved for use in multiple medical specialties, such as the soft corticosteroid loteprednol etabonate for treatment of inflammatory ophthalmic disorders and soft beta-blocker derivatives for treatment of hypertensive emergencies in cardiology. Read More

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Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects.

Mar Drugs 2022 Mar 1;20(3). Epub 2022 Mar 1.

CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.

The loss of density and elasticity, the appearance of wrinkles and hyperpigmentation are among the first noticeable signs of skin aging. Beyond UV radiation and oxidative stress, matrix metalloproteinases (MMPs) assume a preponderant role in the process, since their deregulation results in the degradation of most extracellular matrix components. In this survey, four cyanobacteria strains were explored for their capacity to produce secondary metabolites with biotechnological potential for use in anti-aging formulations. Read More

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Wnt/β-catenin antagonist pyrvinium rescues high dose isoproterenol induced cardiotoxicity in rats: Biochemical and immunohistological evidences.

Chem Biol Interact 2022 May 17;358:109902. Epub 2022 Mar 17.

Department of Pharmacology, Indo Soviet Friendship College of Pharmacy, Moga, Punjab, India.

The up-regulation of Wnt/β-catenin pathway induces cardiac function abnormalities, hypertrophy, and fibrosis in diabetic hypertensive and pressure overload models. The present study investigates the cardioprotective effects of Wnt/β-catenin inhibition on isoproterenol (ISO) induced cardiotoxicity in rats. ISO was administered at a dose of 85 mg/kg (s. Read More

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Molecular interactions of polyvinyl chloride microplastics and beta-blockers (Diltiazem and Bisoprolol) and their effects on marine meiofauna: Combined in vivo and modeling study.

J Hazard Mater 2022 06 2;431:128609. Epub 2022 Mar 2.

University of Carthage, Faculty of Sciences of Bizerte, LR01ES14 Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia. Electronic address:

The ecotoxicological effects of beta-blockers (i.e. Diltiazem and Bisoprolol) and their interactions with the microplastic polyvinyl chloride on marine meiofauna were tested in laboratory microcosms. Read More

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Photodegradation of 5-flurouracil, carvedilol, para-chlorophenol and methimazole with 3D MnWO nanoflower modified AgWO nanorods: A non-genotoxic nanomaterial for water treatment.

Chemosphere 2022 Jun 4;297:134130. Epub 2022 Mar 4.

Nanobiotechnology Laboratory, Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. Electronic address:

The present study focused on the photocatalytic degradation of 5-Flurouracil (FU), carvedilol (Car), para-chlorophenol (PCP) and methimazole (Met) under visible light irradiation by MnWO/AgWO (MWO/AWO) nanohybrid. Here, MWO/AWO nanohybrid was characterized by XRD, TEM, EDS, XPS, ESR, EIS, BET and DRS. The band gap energy of the MWO/AWO nanohybrid was found to be 2. Read More

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Photodegradation of propranolol in surface waters: An important role of carbonate radical and enhancing toxicity phenomenon.

Chemosphere 2022 Jun 25;297:134106. Epub 2022 Feb 25.

School of Water Resources and Hydropower Engineering, North China Electric Power University, Beijing, 102206, China.

Antihypertensive propranolol (PRO) is frequently detected in surface waters and has adverse effects on aquatic organisms. In this study, its photochemical fate in surface water with the aspect of kinetics, products and toxicity were investigated employing steady-state photochemistry experiments and ecotoxicity tests. The results showed that photodegradation of PRO was enhanced in river water than that in phosphate buffer where dissolved organic matter (DOM), NO, and HCO played important roles. Read More

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Prognostic and predictive value of β-blockers in the EORTC 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma.

Eur J Cancer 2022 04 24;165:97-112. Epub 2022 Feb 24.

Division of Cancer Sciences, University of Manchester and Christie NHS Foundation Trust, Manchester, United Kingdom.

Background: β-adrenergic receptors are upregulated in melanoma cells and contribute to an immunosuppressive, pro-tumorigenic microenvironment. This study investigated the prognostic and predictive value of β-adrenoreceptor blockade by β-blockers in the EORTC1325/KEYNOTE-054 randomised controlled trial.

Methods: Patients with resected stage IIIA, IIIB or IIIC melanoma and regional lymphadenectomy received 200 mg of adjuvant pembrolizumab (n = 514) or placebo (n = 505) every three weeks for one year or until recurrence or unacceptable toxicity. Read More

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Protective Effect of Nebivolol against Oxidative Stress Induced by Aristolochic Acids in Endothelial Cells.

Toxins (Basel) 2022 02 10;14(2). Epub 2022 Feb 10.

Laboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles, Erasme Campus, 808 Route de Lennik, B-1070 Brussels, Belgium.

Aristolochic acids (AAs) are powerful nephrotoxins that cause severe tubulointerstitial fibrosis. The biopsy-proven peritubular capillary rarefaction may worsen the progression of renal lesions via tissue hypoxia. As we previously observed the overproduction of reactive oxygen species (ROS) by cultured endothelial cells exposed to AA, we here investigated in vitro AA-induced metabolic changes by H-NMR spectroscopy on intracellular medium and cell extracts. Read More

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February 2022

Protective Effect of Curcumin against Doxazosin- and Carvedilol-Induced Oxidative Stress in HepG2 Cells.

Oxid Med Cell Longev 2022 11;2022:6085515. Epub 2022 Feb 11.

Center of Basic Sciences, Department of Chemistry, Autonomous University of Aguascalientes, 20131 Aguascalientes, Mexico.

Doxazosin and carvedilol have been evaluated as an alternative treatment against chronic liver lesions and for their possible role during the regeneration of damage caused by liver fibrosis in a hamster model. However, these drugs have been reported to induce morphological changes in hepatocytes, affecting the recovery of liver parenchyma. The effects of these /𝛽 adrenoblockers on the viability of hepatocytes are unknown. Read More

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Pharmacological assessment of zebrafish-based cardiotoxicity models.

Biomed Pharmacother 2022 Apr 11;148:112695. Epub 2022 Feb 11.

Department of Biopharmacy, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, Poland. Electronic address:

Cardiotoxicity remains the most common reason for failure during drug development. Recently, the zebrafish (Danio rerio) model has emerged for the evaluation of drug-dependent cardiotoxicity and for the identification of cardioprotective molecules. However, it remains unknown how closely the zebrafish-based results may be translated to humans. Read More

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Toxicological effects of atenolol and venlafaxine on zebrafish tissues: Bioaccumulation, DNA hypomethylation, and molecular mechanism.

Environ Pollut 2022 Apr 23;299:118898. Epub 2022 Jan 23.

School of Environment and Energy, South China University of Technology, Guangzhou, 510006, PR China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, China; The Key Laboratory of Environmental Protection and Eco-Remediation of Guangdong Regular Higher Education Institutions, China. Electronic address:

The beta-blocker atenolol (ATE), and the selective serotonin and norepinephrine reuptake inhibitor, venlafaxine (VEN) are frequently detected in municipal wastewater effluents, but little is known about their ecotoxicological effect on aquatic animals. Herein, ATE and VEN were selected to explore their accumulation and global DNA methylation (GDM) in zebrafish tissues after a 30-day exposure. Molecular dynamics (MD) stimulation was used to investigate the toxic mechanism of ATE and VEN exposure. Read More

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Prolonged Retrobulbar Local Anesthesia of the Cornea Does Not Cause Keratopathy in Mice.

Transl Vis Sci Technol 2022 01;11(1):33

Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Institutes of Medicine, Boston, MA, USA.

Purpose: Prolonged local anesthesia (PLA) of the cornea is currently assumed to cause neurotrophic keratitis and is strongly discouraged. We investigate whether PLA of the cornea per se causes neurotrophic keratitis.

Methods: PLA of the cornea was induced in 12 female albino BALB/c mice by retrobulbar injection of a polymeric prodrug (PGS-TTX) where the site 1 sodium channel blocker tetrodotoxin (TTX) was slowly released from the polymer polyglycerol sebacate. Read More

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January 2022

Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/β-catenin pathway.

Life Sci 2022 Mar 10;293:120304. Epub 2022 Jan 10.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City, Menoufia 32897, Egypt.

The present study aimed to investigate the role of α and β-adrenergic receptors (βARs) in mediation or modulation of the dexamethasone-induced nephrotoxicity by using different pharmacological interventions. Nephrotoxicity was induced by subcutaneous injection of dexamethasone (10 mg/kg) for 7 days in Wistar albino rats. Eight groups were used: control; dexamethasone; carvedilol; phenylephrine; carvedilol and phenylephrine; propranolol; doxazosin; propranolol and doxazosin. Read More

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The Anti-Inflammatory Effect of the β1-Adrenergic Receptor Antagonist Metoprolol on High Glucose Treated Human Microvascular Retinal Endothelial Cells.

Cells 2021 12 24;11(1). Epub 2021 Dec 24.

Biochemistry Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.

Hyperglycemia-induced impairment of the blood-retinal barrier represents the main pathological event in diabetic retinopathy that is elicited by a reduced cellular response to an accumulation of reactive oxygen species (ROS) and increased inflammation. The purpose of the study was to evaluate whether the selective β1-adrenoreceptor (β1-AR) antagonist metoprolol could modulate the inflammatory response to hyperglycemic conditions. For this purpose, human retinal endothelial cells (HREC) were treated with normal (5 mM) or high glucose (25 mM, HG) in the presence of metoprolol (10 μM), epinephrine (1 μM), or both compounds. Read More

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December 2021

Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice.

J Appl Biomed 2021 09 27;19(3):142-148. Epub 2021 May 27.

Lab center of Zhejiang Province People's Hospital, Hangzhou, 310014, PR China.

To study the effect of sinomenine (Sin) on isoproterenol (Iso, β-agonist)-induced cardiac hypertrophy (CH), we set up four mouse groups: control, Iso model, Iso+metoprolol (Met, β blocker) 60 mg/kg and Iso+Sin 120 mg/kg. CH was induced by Iso (s.c. Read More

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September 2021

Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer's disease.

Sci Rep 2021 12 10;11(1):23796. Epub 2021 Dec 10.

Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, 73170, Nakhon Pathom, Thailand.

Alzheimer's disease (AD), one type of dementia, is a complex disease affecting people globally with limited drug treatment. Thus, natural products are currently of interest as promising candidates because of their cost-effectiveness and multi-target abilities. Diplazium esculentum (Retz. Read More

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December 2021

Is hypoglycemia really observed in pediatric beta-blocker intoxications? A case-control study.

Arch Pediatr 2022 Jan 27;29(1):56-60. Epub 2021 Nov 27.

Dokuz Eylül University: Dokuz Eylul Universitesi Institute of Health Servises, Medical Pharmacology Depatment, Toxicology Devision, Turkey; Dokuz Eylul University: Dokuz Eylul Universitesi, Faculty of Medicine, Pharmacology Depatment, Medical Toxicology Devision, Turkey.

Background: Beta-blocker (BB) intoxications are common in both childhood and adulthood. In the case of poisoning, bradycardia, hypotension, ventricular dysrhythmias, mental status changes, seizures, hypoglycemia, and bronchospasm may occur. Effects on the cardiovascular system are commonly seen, but hypoglycemia is not frequently observed in clinical practice. Read More

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January 2022

Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish.

Toxicol Appl Pharmacol 2022 01 26;434:115812. Epub 2021 Nov 26.

Department of Biopharmacy, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, Poland. Electronic address:

Cardiovascular toxicity represents one of the most common reasons for clinical trial failure. Consequently, early identification of novel cardioprotective strategies could prevent the later-stage drug-induced cardiac side effects. The use of zebrafish (Danio rerio) in preclinical studies has greatly increased. Read More

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January 2022

Photodegradation of acebutolol in natural waters: Important roles of carbonate radical and hydroxyl radical.

Chemosphere 2022 Jan 24;287(Pt 3):132318. Epub 2021 Sep 24.

Research Center for Eco-environmental Engineering, Dongguan University of Technology, Dongguan, 523808, PR China.

Acebutolol (ACE) has been widely used for the treatment of cardiovascular disorders, and its photochemical fate in natural waters is a matter of concern due to its ubiquitous occurrence and its toxicity to aquatic organisms. In this study, the photodegradation of ACE in river water and synthetic waters were investigated under simulated sunlight irradiation. The results demonstrated that ACE photodegradation rate in river water was 3. Read More

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January 2022

Chemotherapy-associated cardiomyopathy: Mechanisms of toxicity and cardioprotective strategies.

Pharmacotherapy 2021 12 22;41(12):1066-1080. Epub 2021 Nov 22.

UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.

Objective: To describe the proposed mechanisms of chemotherapy-associated cardiomyopathy (CAC) and potential cardioprotective therapies for CAC including a comprehensive review of existing systematic analyses, guideline recommendations, and ongoing clinical trials.

Data Sources: A literature search of MEDLINE was performed (from 1990 to June 2020) using the following search terms: anthracycline, trastuzumab, cardiomyopathy, cardiotoxicity, primary prevention, angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), beta blocker, dexrazoxane (DEX) as well as using individual names from select therapeutic categories.

Study Selection And Data Extraction: Existing English language systematic analyses and guidelines were considered. Read More

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December 2021

Metoprolol Protects Against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the Sirt1/p53/p21 Axis.

Cardiovasc Toxicol 2022 02 20;22(2):99-107. Epub 2021 Nov 20.

Department of Cardiology, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, No. 43 Renmin Avenue, Meilan District, Haikou, 570208, Hainan, China.

Cardiomyocyte senescence is involved in the pathological mechanism of cardiac diseases. Metoprolol is a β1 receptor blocker used for the treatment of hypertension. Recent studies show that Metoprolol can protect cardiomyocytes against ischemia injury. Read More

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February 2022

Negative inotropic mechanisms of β-cardiotoxin in cardiomyocytes by depression of myofilament ATPase activity without activation of the classical β-adrenergic pathway.

Sci Rep 2021 10 27;11(1):21154. Epub 2021 Oct 27.

Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

Beta-cardiotoxin (β-CTX) from the king cobra venom (Ophiophagus hannah) was previously proposed as a novel β-adrenergic blocker. However, the involvement of β-adrenergic signaling by this compound has never been elucidated. The objectives of this study were to investigate the underlying mechanisms of β-CTX as a β-blocker and its association with the β-adrenergic pathway. Read More

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October 2021