7,627 results match your criteria Toxicity Arsenic


Strategies to inhibit arsenic trioxide-induced cardiotoxicity in acute promyelocytic leukemia.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Arsenic trioxide (ATO) is a drug commonly used for the treatment of acute promyelocytic leukemia (APL). Although ATO has been shown to cause significant improvement in patients, it is associated with serious side effects, which sometimes lead to the patient's death. In this review paper, we examine the reports of ATO-induced cardiotoxicity in APL patients and evaluate the strategies to reduce the incidence of such toxicity. Read More

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http://dx.doi.org/10.1002/jcp.28292DOI Listing
February 2019

Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis.

Food Chem Toxicol 2019 Feb 12;126:41-55. Epub 2019 Feb 12.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, India. Electronic address:

Arsenic contaminated drinking water consumption is a serious health issue around the world. Chronic inorganic arsenic exposure has been associated with respiratory dysfunctions. It exerts various detrimental effects, disrupting normal cellular homeostasis and turning on severe pulmonary complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193007
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http://dx.doi.org/10.1016/j.fct.2019.02.022DOI Listing
February 2019
1 Read

Toward Candidate Proteomic Biomarkers in Clinical Monitoring of Acute Promyelocytic Leukemia Treatment with Arsenic Trioxide.

OMICS 2019 Feb;23(2):119-130

2 School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.

The introduction of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL) has resulted in high clinical complete remission (CR) rates over 90%. On the contrary, the risk for early death (ED) in APL patients treated with ATO continues to have a negative impact for optimization of APL therapeutics. There is an urgent need for precision medicine and biomarkers in clinical monitoring of ATO toxicity in APL, and ED in particular. Read More

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http://dx.doi.org/10.1089/omi.2018.0178DOI Listing
February 2019

The effects of dietary selenomethionine on tissue-specific accumulation and toxicity of dietary arsenite in rainbow trout (Oncorhynchus mykiss) during chronic exposure.

Metallomics 2019 Feb 14. Epub 2019 Feb 14.

Department of Biology, University of Saskatchewan, Saskatoon, SK, Canada. and Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada.

The interactive effects of different doses of dietary selenium [as selenomethionine; 1.8 μg g-1 (control), 10 μg g-1 and 40 μg g-1 diet] on the toxicity of dietary arsenic [as arsenite (As3+); 80 μg As per g diet] were investigated in rainbow trout over an exposure period of 30 days. Fish fed with As3+ alone showed an increased hepatic lipid peroxidation (LPO) and a concomitant decline in cellular redox potential (determined as GSH:GSSG) in the liver tissue relative to the control fish. Read More

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http://dx.doi.org/10.1039/c8mt00309bDOI Listing
February 2019

Heavy metal pollution and potential health risks of commercially available Chinese herbal medicines.

Sci Total Environ 2019 Feb 30;653:748-757. Epub 2018 Oct 30.

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.

A survey was conducted to investigate the pollution and health risks of copper (Cu), cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and zinc (Zn) in 60 Chinese herbal medicines (CHMs) collected from a market in Kunming City, Yunnan Province, China. Furthermore, eight CHMs (Cyathulae radix, Drynariae rhizoma, Peucedani radix, Homalomenae rhizoma, Dryopteris setosa, Polygonati rhizoma, Lilii bulbus, and Linderae radix) containing high Cd concentrations were selected to further analyse their Cd chemical forms. Additionally, the dissolution rates of six heavy metals in decoction liquid were also analysed for four CHMs (Typhonii rhizoma, Linderae radix, Homalomenae rhizoma, and Cyathulae radix), and the health risks of heavy metals in CHMs were evaluated. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.388DOI Listing
February 2019

A candidate for lung cancer treatment: arsenic trioxide.

Authors:
W Huang Y C Zeng

Clin Transl Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medical Oncology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, China.

Arsenic trioxide (ATO), a highly effective drug in treating acute promyelocytic leukemia with low toxicity, demonstrates a significant effect on lung cancer. The anti-cancer mechanisms of ATO include inhibition of cancer stem-like cells, induction of apoptosis, anti-angiogenesis, sensitization of chemotherapy and radiotherapy, anti-cancer effects of hypoxia, and immunoregulation properties. In addition, some studies have reported that different lung cancers respond differently to ATO. Read More

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http://dx.doi.org/10.1007/s12094-019-02054-6DOI Listing
February 2019

Toxicity of As in Crassostrea virginica (Gmelin, 1791) from the Northern Gulf of Mexico at the presence of Zn and its antioxidant defense mechanisms.

Ecotoxicol Environ Saf 2019 Feb 8;172:514-522. Epub 2019 Feb 8.

Environmental Science Ph.D. program, Jackson State University, 1400 J.R. Lynch Street, Jackson, MS, United States.

Reactive oxygen species (ROS) such as the free radicals (e.g. hydroxyl, nitric acid, superoxide) cause damage to lipids, proteins and DNA. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.009DOI Listing
February 2019
2 Reads

GABA mediated reduction of arsenite toxicity in rice seedling through modulation of fatty acids, stress responsive amino acids and polyamines biosynthesis.

Ecotoxicol Environ Saf 2019 Feb 8;173:15-27. Epub 2019 Feb 8.

CSIR-National Botanical Research Institute, Lucknow, India. Electronic address:

γ-aminobutyric acid (GABA) is a free amino acid, which helps to counteract biotic and abiotic stresses in plants. In the present study, two concentrations of GABA, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193016
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http://dx.doi.org/10.1016/j.ecoenv.2019.02.017DOI Listing
February 2019
3 Reads

Developmental neurotoxicity of inorganic arsenic exposure in Sprague-Dawley rats.

Neurotoxicol Teratol 2019 Feb 6;72:49-57. Epub 2019 Feb 6.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, AR 72079, United States of America. Electronic address:

High levels of inorganic arsenic (iAs) exposure are associated with severe health effects. Less clear are effects of lower exposure levels on neurodevelopment. Relative to maternal intake, there is limited lactational transfer of arsenic in humans or rodents, yet there are few rodent studies which directly exposed preweaning animals. Read More

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http://dx.doi.org/10.1016/j.ntt.2019.01.007DOI Listing
February 2019
1 Read
2.762 Impact Factor

High-Protein Diet Ameliorates Arsenic-Induced Oxidative Stress and Antagonizes Uterine Apoptosis in Rats.

Biol Trace Elem Res 2019 Feb 5. Epub 2019 Feb 5.

Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Arsenic toxicity purportedly threats a broad spectrum of female reproductive functions. We investigated the remedial role of a casein- and pea protein-enriched high-protein diet (HPD) in combating the arsenic insult. Cyclic female rats maintained on standard diet (n = 6) or an isocaloric HPD (n = 6) were gavaged with AsO at 3 mg/kg BW/rat/day (n = 12) for 28 days. Read More

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http://dx.doi.org/10.1007/s12011-019-1657-2DOI Listing
February 2019
1 Read

Two-generational effects and recovery of arsenic and arsenate on Daphnia magna in the presence of nano-TiO.

Ecotoxicol Environ Saf 2019 Jan 29;172:136-143. Epub 2019 Jan 29.

School of Space and Environment, Beihang University, Beijing 100191, PR China.

The toxicity of arsenic (As) can be influenced by many environmental factors. Among them, nanomaterials can adsorb arsenic and alter its bioavailability in organisms. However, the studies on long-term effects of arsenic in the presence of nanoparticles are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193010
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http://dx.doi.org/10.1016/j.ecoenv.2019.01.072DOI Listing
January 2019
3 Reads

Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy.

Environ Int 2019 Jan 28;125:43-50. Epub 2019 Jan 28.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications for pregnancy outcomes.

Objective: We aimed to investigate main effects as well as potential SNP-arsenic interactions on arsenic methylation efficiency in pregnant women. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.042DOI Listing
January 2019
2 Reads
5.559 Impact Factor

Metagenomic Evidence for a Species Capable of Bioremediation of Diverse Heavy Metals.

Front Microbiol 2018 9;9:3297. Epub 2019 Jan 9.

College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.

Heavy metal pollution has become an increasingly serious problem worldwide. Co-contamination with toxic mercury (Hg) and arsenic (As) presents a particularly difficult bioremediation trouble. By oxidizing the greenhouse gas methane, methanotrophs have been demonstrated to have high denitrification activity in eutrophic waters, indicating their possible potential for use in bioremediation of Hg(II) and As(V) in polluted water. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333641PMC
January 2019
3 Reads

Influence of algal blooms decay on arsenic dynamics at the sediment-water interface of a shallow lake.

Chemosphere 2019 Mar 11;219:1014-1023. Epub 2018 Dec 11.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Algal blooms decay affects the mobility, bioavailability, and toxicity of arsenic (As) in aquatic environments. The decaying process alters aquatic redox conditions and also introduces ample organic matter, conditions favorable for microbial reduction to simulate As release and As species transformation. This study investigated the role of algae (Microcystis aeruginosa (MA)) blooms decay on the dynamics of labile As and elements associated with its release, such as iron (Fe), manganese (Mn) and sulfide (S), at the sediment-water surface (SWI) of a shallow lake (Lake Taihu) in China, applying mesocosm incubation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.12.080DOI Listing
March 2019
3 Reads

Taurine protected AsO-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway.

Chem Biol Interact 2019 Feb 21;300:123-130. Epub 2019 Jan 21.

Department of Occupational and Environment Health, Dalian Medical University, 9 W Lvshun South Road, Dalian, 116044, PR China; Global Health Research Center, Dalian Medical University, 9 W Lvshun South Road, Dalian, 116044, PR China. Electronic address:

The activation of hepatic stellate cells (HSCs) is a key event in the development of hepatic fibrosis caused by arsenic. However, it is unclear how arsenic induces the activation of HSCs. In the present study, we found that arsenic trioxide (AsO) induced liver tissue damage, stimulated autophagy and HSCs activation, and increased collagen accumulation in the liver of mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183142
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http://dx.doi.org/10.1016/j.cbi.2019.01.019DOI Listing
February 2019
4 Reads

Recent advances in arsenic metabolism in plants: current status, challenges and highlighted biotechnological intervention to reduce grain arsenic in rice.

Metallomics 2019 Jan 23. Epub 2019 Jan 23.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India and Genetics and Molecular Biology Division, CSIR-National Botanical Research Institute, India.

Arsenic (As), classified as a "metalloid" element, is well known for its carcinogenicity and other toxic effects to humans. Arsenic exposure in plants results in the alteration of the physiochemical and biological properties and consequently, loss of crop yield. Being a staple food for half of the world's population, the consumption of As-contaminated rice grain by humans may pose serious health issues and risks for food security. Read More

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http://dx.doi.org/10.1039/c8mt00320cDOI Listing
January 2019
3 Reads

Evaluation of phyto-medicinal efficacy of thymoquinone against Arsenic induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells.

Phytomedicine 2018 Sep 19;54:224-230. Epub 2018 Sep 19.

Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Background: It is evaluated that a few million individuals worldwide are experiencing Arsenic (As) harmfulness coming about because of anthropogenic discharges. There is likewise proof to propose that As can affect the peripheral, as well as, the central nervous system (CNS). On the contrary, thymoquinone (TQ), a biologically active ingredient of Nigella sativa has exhibited numerous neuro-pharmacological traits since ancient times. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.09.197DOI Listing
September 2018
1 Read
3.126 Impact Factor

Occurrence, toxicity, and speciation analysis of arsenic in edible mushrooms.

Food Chem 2019 May 3;281:269-284. Epub 2019 Jan 3.

West China School of Public Health, Sichuan University, Chengdu 610041, China; Provincial Key Laboratory for Food Safety Monitoring and Risk Assessment of Sichuan, Chengdu 610041, China. Electronic address:

Owing to the strong concentration and biotransformation of arsenic, the influence of some edible mushrooms on human health has attracted widespread attention. The toxicity of arsenic greatly depends on its species, so the speciation analysis of arsenic is of critical importance. The aim of the present review is to highlight recent advances in arsenic speciation analysis in edible mushrooms. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.12.103DOI Listing
May 2019
1 Read

Pre- and postnatal environmental boron exposure and infant growth: Results from a mother-child cohort in northern Argentina.

Environ Res 2019 Apr 7;171:60-68. Epub 2019 Jan 7.

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Electronic address:

Background: Experimental studies show developmental toxicity of boron and we recently found impaired weight and length in newborns of mothers exposed to boron through drinking water during pregnancy.

Objectives: To evaluate potential impact of pre- and postnatal boron exposure on infant anthropometry.

Methods: In our mother-child cohort (n = 177) in Argentinean Andes, where drinking water concentrations of boron, lithium and arsenic have been found to vary considerably, we collected maternal blood and urine during and after pregnancy, placenta, breast milk, as well as infant urine and blood during the first 6 months of life. Read More

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http://dx.doi.org/10.1016/j.envres.2019.01.012DOI Listing
April 2019
2 Reads

Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle.

Sci Rep 2019 Jan 14;9(1):107. Epub 2019 Jan 14.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, P.R. China.

Toxicity of arsenic (As) has been widely characterized. However, few studies focus on whether cell responses induced by As at nontoxic concentration could be inherited and further change cell tolerance to another pollutant. In this study, human A549 and HeLa cells were exposed to As at nontoxic concentrations for 10 or 15 passages, then the cells were recovered in the cell medium without As. Read More

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http://dx.doi.org/10.1038/s41598-018-36455-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331635PMC
January 2019
1 Read

Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells.

Chemosphere 2019 Jan 8;221:333-341. Epub 2019 Jan 8.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, PR China.

Microplastics in the environment may gain entry the human gastrointestinal tract through the food chain. However, information on different adverse effects of microplastics at nanometer or micrometer scales in human intestine cells is limited. This study compared the cytotoxicity and efflux pump inhibition ability of 0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.056DOI Listing
January 2019
3 Reads

The toxicity of exogenous arsenic to soil-dwelling springtail Folsomia candida in relation to soil properties and aging time.

Ecotoxicol Environ Saf 2019 Apr 11;171:530-538. Epub 2019 Jan 11.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100000, China; College of Water Sciences, Beijing Normal University, Beijing 100875, China. Electronic address:

Arsenic (As) is a toxic metalloid, but studies on As toxicity to soil-dwelling springtails are fairly limited, and did not consider the effects of various soil properties and long aging time. To address this, the toxicity of As to model organism-Folsomia candida were evaluated in the laboratory studies. The results showed that compared to the soils aged only for 15 d, the concentrations inhibiting 50% reproduction (EC) significantly increased by 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183135
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http://dx.doi.org/10.1016/j.ecoenv.2018.12.059DOI Listing
April 2019
5 Reads

Cytotoxicity of Shear Exfoliated Pnictogen (As, Sb, Bi) Nanosheets.

Chemistry 2019 Feb 14;25(9):2242-2249. Epub 2019 Jan 14.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.

The experimental achievement of phosphorene, which exhibits superior electronic, physical, and optical properties has spurred recent interest in other Group 15 elemental 2D nanomaterials such as arsenene, antimonene, and bismuthene. These unique and superior properties of the pnictogen nanosheets have spurred intensive research efforts and led to the discovery of their diversified potential applications; for instance, optical Kerr material, photonic devices, pnictogen-decorated microfibers, high-speed transistors, and flexible 2D electronics. Previous studies have mainly been dedicated to study the synthesis, properties, and applications of the heavy pnictogens nanosheets; however, the toxicological behaviour of these nanosheets has yet to be established. Read More

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http://doi.wiley.com/10.1002/chem.201804336
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http://dx.doi.org/10.1002/chem.201804336DOI Listing
February 2019
4 Reads

Ameliorative role of antioxidant supplementation on sodium-arsenite induced adverse effects on the developing rat cerebellum.

J Ayurveda Integr Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Anatomy, All Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

Background: Arsenic is an environmental contaminant of global concern. Consumption of ground water contaminated with inorganic arsenic (iAs) continues to be the major source of its exposure. The developing nervous system is especially vulnerable to environmental insults due to its higher rate of oxygen consumption and provision of weaker antioxidant (AOX) machinery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09759476173063
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http://dx.doi.org/10.1016/j.jaim.2018.02.138DOI Listing
January 2019
9 Reads

Trace elements and microbiological parameters in farmed Nile tilapia with emphasis on muscle, water, sediment and feed.

J Environ Sci Health B 2019 Jan 10:1-10. Epub 2019 Jan 10.

a AQUOS-Aquatic Animal Health Laboratory Aquaculture Department , Federal University of Santa Catarina , Rodovia Admar Gonzaga, 1346 , Florianópolis , SC , 88040-900 , Brazil.

Fish may bioaccumulate contaminants from the aquatic environment and extend them to the food chain provoking risks to human health. This study evaluated the microbiological parameters of the pond´s water and trace elements concentrations in samples of water, sediment, feed and muscle of farmed Nile tilapia used for human consumption in southern Brazil. A total of 240 fish were collected from 12 tilapia farms. Read More

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https://www.tandfonline.com/doi/full/10.1080/03601234.2018.1
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http://dx.doi.org/10.1080/03601234.2018.1550308DOI Listing
January 2019
3 Reads

Comparison of Temperate and Tropical Freshwater Species' Acute Sensitivities to Chemicals: An Update.

Integr Environ Assess Manag 2019 Jan 9. Epub 2019 Jan 9.

The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China.

Toxicity data for tropical species are often lacking for deriving water quality guidelines (WQGs) and for conducting ecological risk assessment (ERA). To protect and safeguard valuable natural resources and important biodiversity in tropical freshwater ecosystems, a sound framework should be established to assess and manage the ecological risk of an ever-increasing number of chemicals that occur in the tropics. The present study aims to provide a more up-to-date comparison of the species sensitivity distributions (SSDs) between temperate and tropical freshwater species, by incorporating more acute toxicity data which have been documented. Read More

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http://dx.doi.org/10.1002/ieam.4122DOI Listing
January 2019
8 Reads

Cotreatment of MSWI Fly Ash and Granulated Lead Smelting Slag Using a Geopolymer System.

Int J Environ Res Public Health 2019 Jan 8;16(1). Epub 2019 Jan 8.

Institute of Environmental Science and Engineering, School of Metallurgy and Environment, Central South University, Changsha 410083, Hunan, China.

Municipal solid waste incineration fly ash (MSWI FA) and granulated lead smelting slag (GLSS) are toxic industrial wastes. In the present study, granulated lead smelting slag (GLSS) was pretreated as a geopolymer precursor through the high-energy ball milling activation process, which could be used as a geopolymeric solidification/stabilization (S/S) reagent for MSWI FA. The S/S process has been estimated through the physical properties and heavy metals leachability of the S/S matrices. Read More

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http://dx.doi.org/10.3390/ijerph16010156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339166PMC
January 2019
2 Reads

Metals and Mechanisms of Carcinogenesis.

Annu Rev Pharmacol Toxicol 2019 Jan;59:537-554

Departments of Environmental Medicine, and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10010, USA; email:

Metal exposure is pervasive and not limited to sporadic poisoning events or toxic waste sites. Hundreds of millions of people around the globe are affected by chronic metal exposure, which is associated with serious health concerns, including cancer, as demonstrated in a variety of studies at the molecular, systemic, and epidemiologic levels. Metal-induced toxicity and carcinogenicity are sophisticated and complex in nature. Read More

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http://dx.doi.org/10.1146/annurev-pharmtox-010818-021031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348465PMC
January 2019
7 Reads

An Overview on Arsenic Trioxide-Induced Cardiotoxicity.

Cardiovasc Toxicol 2019 Jan 7. Epub 2019 Jan 7.

Agroprocessing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR - NIIST), Thiruvananthapuram, Kerala, 695019, India.

Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from receiving this highly effective treatment. Read More

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http://dx.doi.org/10.1007/s12012-018-09504-7DOI Listing
January 2019
2 Reads

KML001, an arsenic compound, as salvage chemotherapy in refractory biliary tract cancers: A prospective study.

Hepatobiliary Pancreat Dis Int 2019 Feb 28;18(1):62-66. Epub 2018 Dec 28.

Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Electronic address:

Background: Sodium meta-arsenite (NaAsO, KML001) is a potential oral anticancer agent acting on telomerase and telomere length. This prospective study evaluated its safety, tolerability, and effectiveness as salvage chemotherapy in patients with advanced biliary tract cancer (BTC) resistant to gemcitabine-based chemotherapy.

Methods: Forty-four patients (21 women and 23 men) with advanced BTC and failure history of gemcitabine-based chemotherapy, performance status (PS) 0-2, normal cardiac, hepatic, and renal function were enrolled. Read More

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http://dx.doi.org/10.1016/j.hbpd.2018.12.009DOI Listing
February 2019
3 Reads

Prevalence of rheumatoid arthritis in relation to serum cadmium concentrations: cross-sectional study using Korean National Health and Nutrition Examination Survey (KNHANES) data.

BMJ Open 2019 Jan 3;9(1):e023233. Epub 2019 Jan 3.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Objectives: It has been suggested that exposure to heavy metal cadmium (Cd) may contribute to a high risk of developing rheumatoid arthritis (RA). This study was to investigate the association of RA prevalence and serum concentrations of Cd and other heavy metals through large survey data analysis.

Design: A retrospective cross-sectional survey study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326419PMC
January 2019
1 Read

Efficient arsenate reduction by As-resistant bacterium Bacillus sp. strain PVR-YHB1-1: Characterization and genome analysis.

Chemosphere 2019 Mar 23;218:1061-1070. Epub 2018 Nov 23.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China; Soil and Water Science Department, University of Florida, Gainesville, FL, 32611, United States. Electronic address:

Arsenate (AsV) reduction in bacteria is essential to alleviate their arsenic (As) toxicity. We isolated a Bacillus strain PVR-YHB1-1 from the roots of As-hyperaccumulator Pteris vittata. The strain was efficient in reducing AsV to arsenite (AsIII), but the associated mechanisms were unclear. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.145DOI Listing
March 2019
2 Reads

Evaluation of the effectiveness of in situ stabilization in the field aged arsenic-contaminated soil: Chemical extractability and biological response.

J Hazard Mater 2019 Apr 15;367:137-143. Epub 2018 Dec 15.

Department of Civil & Environmental Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08733, Republic of Korea. Electronic address:

The effectiveness of in situ stabilization in the long-term As-contaminated soil was assessed. In situ stabilization of As was conducted through a Fe-based sorbent amendment. Chemical extractability of As was first determined by solubility/bioavailability research consortium extraction method and any change in human health risk through oral ingestion was characterized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043894183119
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http://dx.doi.org/10.1016/j.jhazmat.2018.12.050DOI Listing
April 2019
3 Reads

[Estimation of bioaccessibility and risk assessment of heavy metals in decoction pieces of Bupleuri Radix].

Zhongguo Zhong Yao Za Zhi 2018 Nov;43(22):4479-4485

Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, China.

This project was launched to study on the overall residual status of heavy metals of comprehensive understanding in decoction pieces of Bupleuri Radix (DPBR) from different habitats and risk assessment. In this study, inductively coupled plasma mass spectrometry was used to determine the heavy metals of 30 batches of Bupleuri Radix in different producing areas. Simulated gastrointestinal fluid method was used to determine the dissolution rate of heavy metals in the simulated gastrointestinal fluid and the average daily intake Average Daily Dose (ADD) and Hazard Quotient (HQ) index were used to assess the risk of heavy metals in DPBR. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180724.002DOI Listing
November 2018
1 Read

Responses of soil fungal and archaeal communities to environmental factors in an ongoing antimony mine area.

Sci Total Environ 2019 Feb 23;652:1030-1039. Epub 2018 Oct 23.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China. Electronic address:

Microorganisms are vital to biogeochemical cycles. However, heavy metal contamination has been implicated in altering the microbial community. Antimony (Sb) and arsenic (As) in soils can alter soil bacterial community composition in previous studies and, therefore, may have effects on soil fungal and archaeal community composition. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.300DOI Listing
February 2019
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Arsenic contamination in groundwater in Bangladesh: implications and challenges for healthcare policy.

Risk Manag Healthc Policy 2018 30;11:251-261. Epub 2018 Nov 30.

Department of Occupational and Environmental Health, National Institute of Preventive Medicine, Mohakhali, Dhaka 1212, Bangladesh.

Arsenic contamination of groundwater in Bangladesh has been recognized as a major public problem. The arsenic contamination was first identified in the tubewell water in 1993 in a northern district of Bangladesh. Tubewells are the main source of drinking water in rural areas, and except hilly and terrace upland throughout the Bangladesh, the arsenic-contaminated tube-wells are distributed. Read More

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http://dx.doi.org/10.2147/RMHP.S153188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281155PMC
November 2018
8 Reads

Synthesis and application of Zn/Ce bimetallic oxides for the decontamination of arsenite (As-III) ions from aqueous solutions.

J Environ Manage 2019 Mar 20;233:151-164. Epub 2018 Dec 20.

Department of Chemistry, Indian Institute of Technology (Banaras Hindu University) Varanasi, Varanasi, 221005, India. Electronic address:

Arsenic contamination has threatened water safety due to its high toxicity and carcinogenicity. Therefore, it is urgent and significant to develop simple and effective approach for dearsenification of drinking water. In present study, Zn/Ce bimetallic oxide particles of various atomic ratios were synthesized by sol-gel process and were applied for adsorption of arsenite from aqueous solutions. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.11.107DOI Listing

Concrete stabilization of arsenic-bearing iron sludge generated from an electrochemical arsenic remediation plant.

J Environ Manage 2019 Mar 19;233:141-150. Epub 2018 Dec 19.

Department of Civil Engineering, Jadavpur University, Kolkata 700 032, India.

In this study, concrete stabilization is adopted to sustainably manage hazardous arsenic-iron sludge near the vicinity of a community-based arsenic water treatment plant for potential use as material for local construction. The strength and workability of the sludge mixed with fresh concrete were investigated to determine the suitability of the concrete mixture for building materials. We found that over 25% sludge (with respect to cement weight) can be incorporated safely into different grades of concrete (M15 and M20). Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.11.062DOI Listing
March 2019
2 Reads

The gut microbiome is required for full protection against acute arsenic toxicity in mouse models.

Nat Commun 2018 12 21;9(1):5424. Epub 2018 Dec 21.

Department of Microbiology & Immunology, 109 Lewis Hall, Montana State University, Bozeman, MT, 59717, USA.

Arsenic poisons an estimated 200 million people worldwide through contaminated food and drinking water. Confusingly, the gut microbiome has been suggested to both mitigate and exacerbate arsenic toxicity. Here, we show that the microbiome protects mice from arsenic-induced mortality. Read More

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http://dx.doi.org/10.1038/s41467-018-07803-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303300PMC
December 2018
2 Reads

Arsenic Exposure and Effects in Humans: A Mini-Review in Brazil.

Arch Environ Contam Toxicol 2018 Dec 19. Epub 2018 Dec 19.

Laboratório de Ciências Ambientais, Centro de Biociências e Biotecnologia-Avenida Alberto Lamego, Universidade Estadual do Norte Fluminense, 2000, Horto, Campos dos Goytacazes, RJ, 28015-620, Brazil.

Arsenic (As) is widely studied in several countries due to its toxicity to biota in the environment. Arsenic sources may be natural or anthropogenic, and the mobility of the element is ruled by physicochemical conditions that also define the dominant As species in the environment. Arsenic levels are evaluated in various abiotic and biotic environmental samples. Read More

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http://dx.doi.org/10.1007/s00244-018-00586-6DOI Listing
December 2018
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Arsenic exposure and young adult's mortality risk: A 13-year follow-up study in Matlab, Bangladesh.

Environ Int 2019 Feb 18;123:358-367. Epub 2018 Dec 18.

ICDDRB, 68 Shahid Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.

Background: Widespread arsenic contamination in underground water is a well-documented public health concern that threatens millions of lives worldwide. We investigated the risk of young-adult mortality due to high chronic exposure to arsenic through years of drinking arsenic contaminated water.

Methods: A prospective cohort study of 58,406 individuals was enrolled who were 4-18 years at baseline. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.006DOI Listing
February 2019
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Foliar uptake of arsenic nanoparticles by spinach: an assessment of physiological and human health risk implications.

Environ Sci Pollut Res Int 2018 Dec 17. Epub 2018 Dec 17.

Institute of Soil and Environmental Sciences, University of Agriculture Faisalabad, Faisalabad, 38040, Pakistan.

Atmospheric contamination by heavy metal(loid)-enriched particulate matter (metal-PM) is highly topical these days because of its high persistence, toxic nature, and health risks. Globally, foliar uptake of metal(loid)s occurs for vegetables/crops grown in the vicinity of industrial or urban areas with a metal-PM-contaminated atmosphere. The current study evaluated the foliar uptake of arsenic (As), accumulation of As in different plant organs, its toxicity (in terms of ROS generation, chlorophyll degradation, and lipid peroxidation), and its defensive mechanism (antioxidant enzymes) in spinach (Spinacia oleracea) after foliar application of As in the form of nanoparticles (As-NPs). Read More

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http://dx.doi.org/10.1007/s11356-018-3867-0DOI Listing
December 2018
1 Read
2.828 Impact Factor

Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity in female rats.

Hum Exp Toxicol 2018 Dec 17:960327118818246. Epub 2018 Dec 17.

2 Department of Zoology and Entomology, Faculty of Science, Helwan University, Helwan, Egypt.

The aim of this study is to investigate the protective effects of thymoquinone (TQ) and ebselen (Eb) on arsenic (As)-induced renal toxicity in female rats. Sodium arsenite was orally administrated at a dose of 20 mg/kg body weight daily for 28 days, either alone or 1 h before TQ (10 mg/kg) or Eb (5 mg/kg) administration. Renal tissue As concentration and oxidative stress markers, including lipid peroxidation (LPO), nitrite/nitrate, and glutathione (GSH) levels, were determined. Read More

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http://journals.sagepub.com/doi/10.1177/0960327118818246
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http://dx.doi.org/10.1177/0960327118818246DOI Listing
December 2018
4 Reads

Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic.

Ecotoxicol Environ Saf 2019 Apr 14;170:513-520. Epub 2018 Dec 14.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China. Electronic address:

Arsenic poses a profound health risk including male reproductive dysfunction upon prolonged exposure. Histone methylation is an important epigenetic driver; however, its role in arsenic- induced steroidogenic pathogenesis remains obscure. In current study, we investigated the effect of histone H3K9 tri-methylation (H3K9me3) on expression pattern of steroidogenic genes in rat testis after long-term arsenic exposure. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.035DOI Listing
April 2019
3 Reads

An overview of plant-based interventions to ameliorate arsenic toxicity.

Biomed Pharmacother 2019 Jan 5;109:838-852. Epub 2018 Nov 5.

Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), SASTRA Deemed-to-be University, Thanjavur, 613 401, India. Electronic address:

The industrial and technological advancements in the world have also contributed to the rapid deterioration in the environment quality through introduction of obnoxious pollutants that threaten to destroy the subtle balance in the ecosystem. The environment contaminants cause severe adverse effects to humans, flora and fauna that are mostly irreversible. Chief among these toxicants is arsenic, a metalloid, which is considered among the most dangerous environmental toxins that leads to various diseases which affect the quality of life even when present in small quantities. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.099DOI Listing
January 2019

Heavy Metal and Metalloid Pollution of Soil, Water and Foods in Bangladesh: A Critical Review.

Int J Environ Res Public Health 2018 12 11;15(12). Epub 2018 Dec 11.

Key Laboratory for Agricultural Water Resources, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China.

Bangladesh is a densely populated developing country. Both industrialization and geological sources have caused widespread heavy metal and metalloid pollution in Bangladesh, which is now posing substantial threats to the local people. In this review, we carried out one of the most exhaustive literature analyses on the current status of Bangladesh heavy metal and metalloid pollution, covering water, soil, and foods. Read More

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http://www.mdpi.com/1660-4601/15/12/2825
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http://dx.doi.org/10.3390/ijerph15122825DOI Listing
December 2018
16 Reads
2.063 Impact Factor

Arsenic trioxide and/or copper sulfate induced apoptosis and autophagy associated with oxidative stress and perturbation of mitochondrial dynamics in the thymus of Gallus gallus.

Chemosphere 2019 Mar 4;219:227-235. Epub 2018 Dec 4.

College of Wildlife Resources, Northeast Forestry University, Harbin 150040, Heilongjiang Province, China. Electronic address:

Arsenic (As) and copper (Cu) are ubiquitous environmental contaminants that are hazardous to the immune system. Our objective was to investigate the toxicity and potential mechanisms of thymus exposure to As and/or Cu. A chicken model was established by adding arsenic trioxide (AsO; 30 mg/kg), copper sulfate (CuSO; 300 mg/kg), and simultaneously both elements in the basal diet. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.188DOI Listing

Groundwater Irrigation and Arsenic Speciation in Rice in Cambodia.

J Health Pollut 2018 Sep 10;8(19):180911. Epub 2018 Sep 10.

University of Ottawa, Canada.

Background: Arsenic bioaccumulation in rice is a global concern affecting food security and public health.

Objective: The present study examined arsenic species in rice in Cambodia to characterize health risks with rice consumption and to clarify uncertainties with Codex guidelines.

Methods: The present study collected 61 well water samples, 105 rice samples, 70 soil samples, and conducted interviews with 44 families in Preak Russey near the Bassac River and Kandal Province along the Mekong River in Cambodia. Read More

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http://dx.doi.org/10.5696/2156-9614-8.19.180911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257176PMC
September 2018
2 Reads

Effects of Arsenic, Iron and Fertilizers in Soil on Rice in Cambodia.

J Health Pollut 2018 Sep 10;8(19):180910. Epub 2018 Sep 10.

University of Ottawa, Canada.

Background: In parts of Cambodia, irrigation with groundwater results in arsenic accumulation in soils and rice, leading to health concerns associated with rice consumption. A high concentration of iron in groundwater can precipitate arsenic and reduce its bioavailability, however high concentrations of arsenic and iron can also reduce rice production. Furthermore, concerns have been raised about chemical contamination from inorganic fertilizers used to grow rice. Read More

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http://www.journalhealthpollution.org/doi/10.5696/2156-9614-
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http://dx.doi.org/10.5696/2156-9614-8.19.180910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257173PMC
September 2018
9 Reads

The return of gemtuzumab ozogamicin: a humanized anti-CD33 monoclonal antibody-drug conjugate for the treatment of newly diagnosed acute myeloid leukemia.

Onco Targets Ther 2018 22;11:8265-8272. Epub 2018 Nov 22.

Division of Hematology and Oncology, Rhode Island Hospital, The Alpert Medical School of Brown University, Providence, RI, USA,

Through the years gemtuzumab ozogamicin (GO) has moved from a panacea in the treatment of acute myeloid leukemia (AML) to a pariah and back again. Early promise of targeted therapy with accelerated approval in the United States in 2000 gave way to fear over increased toxicity in the absence of efficacy, which subsequently resulted in the drug manufacturer voluntarily withdrawing GO from the market in 2010. We outline the history of GO in terms of initial drug development and early clinical trials that ultimately led the way to GO frontline use in AML based on a series of Phase III studies. Read More

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http://dx.doi.org/10.2147/OTT.S150807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254990PMC
November 2018
1 Read