8,986 results match your criteria Toxicity Arsenic

Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo.

Toxicol Appl Pharmacol 2021 Jun 8:115617. Epub 2021 Jun 8.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality from liver disorders. Various mechanisms, including oxidative stress and impaired lipid metabolism, have been implicated in the pathogenesis of ALD. Our previous studies showed that nuclear factor erythroid-derived 2-like 2 (Nrf2) is a master regulator of adaptive antioxidant response and lipid metabolism by using a liver-specific Nrf2 knockout (Nrf2(L)-KO) mouse model. Read More

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Toxic effects of selected trace elements contained in make-ups on female university students in Nigeria.

Environ Monit Assess 2021 Jun 11;193(7):412. Epub 2021 Jun 11.

Institute for Development Studies, University of Nigeria, Enugu Campus, Enugu, Nigeria.

Arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), beryllium (Be), nickel (Ni), selenium (Se), and thallium (Tl) are reportedly notorious toxic contents of make-ups, with potential to cause cancer and chronic kidney disease, warranting investigation on their toxic effects. One hundred female university students were randomly selected as consistent users of make-ups for upward of 3 years. The serum/urine levels of the 8 elements were regressed against the kidney functions (estimated glomerular rate, eGFR) of the subjects. Read More

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Dynamics of Dimethylated Monothioarsenate (DMMTA) in Paddy Soils and Its Accumulation in Rice Grains.

Environ Sci Technol 2021 Jun 10. Epub 2021 Jun 10.

Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.

Arsenic species transformation in paddy soils has important implications for arsenic accumulation in rice grains and its safety to the consumers. Methylated thioarsenates including highly toxic dimethylated monothioarsenate (DMMTA) have been detected in paddy soils, but their production and dynamics remain poorly understood. In the present study, we first optimized a HPLC-ICP-MS method to quantify methylated thioarsenate species. Read More

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Potentiating response of D- Ribose-L-Cysteine on Sodium arsenateinduced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat.

JBRA Assist Reprod 2021 Jun 9. Epub 2021 Jun 9.

Human Anatomy Department, Federal University of Technology Akure, Ondo State.

Objective: Reproductive toxicity is an important health challenge, mostly associated with exposure to several environmental toxicants. Arsenic is a ubiquitous toxic compound naturally present in the environment. This study was carried out to evaluate the dietary supplements of D-Ribose-L-Cysteine against sodium arsenate-induced testicular toxicity in adult male Wistar rats. Read More

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A review on sources, identification and treatment strategies for the removal of toxic Arsenic from water system.

J Hazard Mater 2021 Jun 2;418:126299. Epub 2021 Jun 2.

Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Chennai 603110, India; Centre of Excellence in Water Research (CEWAR), Sri Sivasubramaniya Nadar College of Engineering, Chennai 603110, India. Electronic address:

Arsenic liberation and accumulation in the groundwater environment are both affected by the presence of primary ions and soluble organic matter. The most important influencing role in the co-occurrence is caused by human activity, which includes logging, agricultural runoff stream, food, tobacco, and fertilizers. Furthermore, it covers a wide range of developed and emerging technologies for removing arsenic impurities from the ecosystem, including adsorption, ion exchangers, bio sorption, coagulation and flocculation, membrane technology and electrochemical methods. Read More

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Therapeutic potential of diosmin, a citrus flavonoid against arsenic-induced neurotoxicity via suppression of NOX 4 and its subunits.

Indian J Pharmacol 2021 Mar-Apr;53(2):132-142

Department of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India.

Objectives: Water contaminated with arsenic affected millions of people worldwide and arsenic exposure is related to various neurological disorders. Hence, the current study was planned to investigate the neuroprotective activity of diosmin (DSN) against arsenic induced neurotoxicity as an attempt to identify therapeutic intervention to combat arsenicism.

Materials And Methods: Sodium arsenite an inducer of neurotoxicity was administered orally (13 mg/kg) and DSN treatment at two selected doses (50 and 100 mg/kg) was done for 21 days. Read More

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Environmental Toxins Found Historically in the Polycythemia Vera Cluster Area and their Potential for Inducing DNA Damage.

J Environ Anal Toxicol 2021 Feb;8(1)

Icahn School of Medicine, Mt. Sinai, New York, NY, USA.

In 2006, the Agency for Toxic Substances and Disease Registry received a request to determine whether a cluster of polycythemia vera patients existed in a northeast Pennsylvania community. A significant cluster of PV cases was identified at the nexus of three counties near several hazardous waste sites. The current study evaluated the potential for a select number of environmental contaminants previously detected in the cluster area to induce DNA damage using assays with hematopoietic stem-cell derived progenitor cells. Read More

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February 2021

The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Circulating in Europe.

Front Microbiol 2021 21;12:651124. Epub 2021 May 21.

Department of Bacteriology, Animal and Plant Health Agency, Addlestone, United Kingdom.

The European epidemic monophasic variant of enterica serovar (. 1,4,[5],12:i:-) characterized by the multi sequence type ST34 and the antimicrobial resistance ASSuT profile has become one of the most common serovars in Europe (EU) and the United States (US). In this study, we reconstructed the time-scaled phylogeny and evolution of this in Europe. Read More

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Heavy metal detoxification mechanisms by microalgae: Insights from transcriptomics analysis.

Environ Pollut 2021 May 27;285:117443. Epub 2021 May 27.

Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India; Centre for Transportation Systems, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:

Heavy metal pollution in ecosystem is a global threat. The associated toxicity and carcinogenic nature of heavy metals/metalloids such as mercury, cadmium, lead, and arsenic are imposing a severe risk to both ecological diversity and human lives. Harnessing the adaptive feature of microalgae for remediating toxic heavy metal has reached a milestone in past few decades. Read More

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Strigolactones regulate arsenate uptake, vacuolar-sequestration and antioxidant defense responses to resist arsenic toxicity in rice roots.

J Hazard Mater 2021 08 5;415:125589. Epub 2021 Mar 5.

Stress Adaptation Research Unit, RIKEN Center for Sustainable Resource Science, 1-7-22, Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan; Institute of Research and Development, Duy Tan University, 03 Quang Trung, Da Nang 550000, Vietnam; Institute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock 79409, TX, USA. Electronic address:

We explored genetic evidence for strigolactones' role in rice tolerance to arsenate-stress. Comparative analyses of roots of wild-type (WT) and strigolactone-deficient mutants d10 and d17 in response to sodium arsenate (NaAsO) revealed differential growth inhibition [WT (11.28%) vs. Read More

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Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity.

J Cell Sci 2021 Jun 4;134(11). Epub 2021 Jun 4.

Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, SE-405 30 Göteborg, Sweden.

The toxic metalloid arsenic causes widespread misfolding and aggregation of cellular proteins. How these protein aggregates are formed in vivo, the mechanisms by which they affect cells and how cells prevent their accumulation is not fully understood. To find components involved in these processes, we performed a genome-wide imaging screen and identified Saccharomyces cerevisiae deletion mutants with either enhanced or reduced protein aggregation levels during arsenite exposure. Read More

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Human Milk Concentrations of Minerals, Essential and Toxic Trace Elements and Association with Selective Medical, Social, Demographic and Environmental Factors.

Nutrients 2021 May 31;13(6). Epub 2021 May 31.

Department of Neonatology, University Clinical Hospital of Santiago de Compostela, 15704 Santiago de Compostela, Spain.

This study aims to quantify concentrations of minerals and trace elements in human milk (HM) and infant formula (IF) and evaluate associations with medical, social, environmental, and demographic variables. A prospective, case series study of 170 nursing mothers was made. HM samples were obtained from full-term (colostrum, intermediate and mature HM) and preterm (mature HM) mothers. Read More

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Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo.

Int J Environ Res Public Health 2021 May 6;18(9). Epub 2021 May 6.

Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo.

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Read More

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Riboflavin recovery of spermatogenic dysfunction via a dual inhibition of oxidative changes and regulation of the PINK1-mediated pathway in arsenic-injured rat model.

A Olfati E Tvrda

Physiol Res 2021 Jun 1. Epub 2021 Jun 1.

Young Researchers and Elites Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.

Arsenic trioxide (As(2)O(3)) poisoning and associated potential lesions are of a global concern. Inversely, riboflavin (vitamin B2, VB2) as a component of flavoproteins could play a vital role in the spermatogenic enzymatic reactions. Thus, this research aimed to explore potential beneficial roles of VB2 during As(2)O(3)-injured-toxicity. Read More

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Arsenic behavior in soil-plant system and its detoxification mechanisms in plants: A review.

Environ Pollut 2021 May 21;286:117389. Epub 2021 May 21.

College of Grassland Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China. Electronic address:

Arsenic (As) is one of the most toxic and cancer-causing metals which is generally entered the food chain via intake of As contaminated water or food and harmed the life of living things especially human beings. Therefore, the reduction of As content in the food could be of great importance for healthy life. To reduce As contamination in the soil and food, the evaluation of plant-based As uptake and transportation mechanisms is critically needed. Read More

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Efficiency of arsenic remediation from growth medium through Bacillus licheniformis modulated by phosphate (PO) and nitrate (NO) enrichment.

Arch Microbiol 2021 May 30. Epub 2021 May 30.

Laboratory of Environment and Biotechnology, Department of Botany, Patna Science College, Patna University, Patna, 800005, India.

Bacillus licheniformis DAS-1 and DAS-2 were found as potent tool for removal/uptake of arsenic [As(V) and As(III)] and reduction [(As(V) to As(III)] of arsenic from the liquid growth medium in our previous studies. Present work gives light on modulation of arsenic remediation (in terms of uptake and reduction) by two selected essential soil nutrients, phosphate (PO) and nitrate (NO). PO has structural analogy with arsenate [AsO/As(V)] that compete with cell uptake of As(V). Read More

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Effects of heavy metals on reproduction owing to infertility.

J Biochem Mol Toxicol 2021 May 29:e22823. Epub 2021 May 29.

Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra, Haryana, India.

The reproductive performance of most of the species is adversely affected by hazardous heavy metals like lead, cadmium, mercury, arsenic, zinc, and copper. Heavy metals are liberated in the environment by natural sources like rock weathering, volcanic eruption, and other human activities like industrial discharge, mineral mining, automobile exhaust, and so forth. Heavy metals alter several reproductive functions in both males and females like a decrease in sperm count, motility, viability, spermatogenesis, hormonal imbalance, follicular atresia, and delay in oocyte maturation, and so forth, and thus, forms an important aspect of reproductive toxicology. Read More

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The Pedosphere as a Sink, Source, and Record of Anthropogenic and Natural Arsenic Atmospheric Deposition.

Environ Sci Technol 2021 May 28. Epub 2021 May 28.

School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, Northern Ireland.

The Anthropocene has led to global-scale contamination of the biosphere through diffuse atmospheric dispersal of arsenic. This review considers the sources arsenic to soils and its subsequent fate, identifying key knowledge gaps. There is a particular focus on soil classification and stratigraphy, as this is central to the topic under consideration. Read More

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[Seasonal variations and driving factors of phytoplankton community shift in Datun Lake with long-term stress of arsenic contamination.]

Ying Yong Sheng Tai Xue Bao 2021 May;32(5):1845-1853

Faculty of Geography/Yunnan Key Laboratory of Plateau Geographical Processes and Environmental Change, Yunnan Normal University, Kunming 650500, China.

Heavy metal is an important environmental stress that threatens water quality and ecological health of surface waters. Therefore, it is vital to identify the responses of lake community to long-term pollution for sustainable ecological restoration of polluted lakes. From June 2017 to March 2018, we conducted a seasonal survey of phytoplankton and environmental factors in Datun Lake, which had a decadal history of tailing-related arsenic contamination. Read More

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Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of in Wistar Rats.

J Evid Based Integr Med 2021 Jan-Dec;26:2515690X211017464

Department of Biochemistry, Cancer Research and Molecular Biology Laboratories, 58987University of Ibadan, Oyo, Nigeria.

Toxicities due to exposure to arsenic-contaminated water and the occurrence of diabetes mellitus are major health concerns. Treatment of these concerns using therapeutic measures have recorded limited success. Traditionally, (LA) has been used in managing various diseases. Read More

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Soil arsenic toxicity differentially impacts C3 (barley) and C4 (maize) crops under future climate atmospheric CO.

J Hazard Mater 2021 07 6;414:125331. Epub 2021 Feb 6.

Department of Botany and Microbiology, Faculty of Science, Cairo University, Giza, Egypt.

Soil arsenic (As) contamination limits global agricultural productivity. Anthropogenic emissions are causing atmospheric CO levels to rise. Elevated CO (eCO) boosts plant growth both under optimal and suboptimal growth conditions. Read More

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Current permissible levels of metal pollutants harm terrestrial invertebrates.

Sci Total Environ 2021 Jul 17;779:146398. Epub 2021 Mar 17.

Research Center on Animal Cognition (CRCA), Center for Integrative Biology (CBI); CNRS, University Paul Sabatier, Toulouse III, France. Electronic address:

The current decline of invertebrates worldwide is alarming. Several potential causes have been proposed but metal pollutants, while being widespread in the air, soils and water, have so far been largely overlooked. Here, we reviewed the results of 527 observations of the effects of arsenic, cadmium, lead and mercury on terrestrial invertebrates. Read More

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Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity.

Arch Toxicol 2021 May 24. Epub 2021 May 24.

IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Metal dyshomeostasis, and especially overexposure, is known to cause adverse health effects due to modulation of a variety of metabolic pathways. An increasing body of literature has demonstrated that metal exposure may affect SIRT signaling, although the existing data are insufficient. Therefore, in this review we discuss the available data (PubMed-Medline, Google Scholar) on the influence of metal overload on sirtuin (SIRT) signaling and its association with other mechanisms involved in metal-induced toxicity. Read More

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Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia.

Clin Case Rep 2021 May 15;9(5):e04115. Epub 2021 May 15.

Division of Hematology/Oncology Massachusetts General Hospital Boston MA USA.

Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications. Read More

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Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks.

Sci Total Environ 2021 May 15;788:147780. Epub 2021 May 15.

College of Veterinary Medicine, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Arsenic is an important hazardous metalloid commonly found in polluted soil, rivers and groundwater. However, few studies exist regarding the effect of arsenic trioxide (ATO) on the gut-liver axis and consequent hepatotoxicity in waterfowl. Here, we investigated the influence of ATO on duck intestines and livers, and explored the role of the gut-liver axis in ATO-induced hepatotoxicity and intestinal toxicity. Read More

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Biochar mitigates arsenic-induced human health risks and phytotoxicity in quinoa under saline conditions by modulating ionic and oxidative stress responses.

Environ Pollut 2021 May 15;287:117348. Epub 2021 May 15.

Department of Environmental Sciences, COMSATS University Islamabad, Vehari Campus, 61100, Pakistan.

Arsenic (As) is a toxic metalloid and its widespread contamination in agricultural soils along with soil salinization has become a serious concern for human health and food security. In the present study, the effect of cotton shell biochar (CSBC) in decreasing As-induced phytotoxicity and human health risks in quinoa (Chenopodium quinoa Willd.) grown on As-spiked saline and non-saline soils was evaluated. Read More

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Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres.

Brayden Whitlock

Int J Toxicol 2021 May-Jun;40(3):211-217

University of Alberta Health Accelerator, Edmonton, Alberta, Canada.

Arsenic is both a chemotherapeutic drug and an environmental toxicant that affects hundreds of millions of people each year. Arsenic exposure in drinking water has been called the worst poisoning in human history. How arsenic is handled in the body is frequently studied using rodent models to investigate how arsenic both causes and treats disease. Read More

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Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats.

Drug Chem Toxicol 2021 May 18:1-7. Epub 2021 May 18.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India.

Arsenic exposure causes immense health distress by increasing risk of cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. The present study explored the role of inducible nitric oxide synthase (iNOS) inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats. Female Sprague Dawley rats were subjected to arsenic toxicity by administering sodium arsenite (5 mg/kg/day, oral) for 4 weeks. Read More

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Exogenous melatonin regulates endogenous phytohormone homeostasis and thiol-mediated detoxification in two indica rice cultivars under arsenic stress.

Plant Cell Rep 2021 May 18. Epub 2021 May 18.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata, West Bengal, 700016, India.

Key Message: Melatonin enhanced arsenic (As) tolerance by inhibiting As bioaccumulation, modulating the expression of As transporters and phytohormone homeostasis, leading to efficient utilization of thiol machinery for sequestration and detoxification of this toxic metalloid. The present study was aimed at investigating the influence of exogenous melatonin on the regulation of endogenous plant growth regulators and their cumulative effects on metal(loid)-binding ligands in two contrasting indica rice cultivars, viz., Khitish (arsenic sensitive) and Muktashri (arsenic tolerant) under arsenic stress. Read More

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Metal pollutants have additive negative effects on honey bee cognition.

J Exp Biol 2021 May 18. Epub 2021 May 18.

Department of Biological Sciences, Macquarie University, NSW, Australia.

Environmental pollutants can exert sublethal deleterious effects on animals. These include disruption of cognitive functions underlying crucial behaviours. While agrochemicals have been identified as a major threat to pollinators, metal pollutants, which are often found in complex mixtures, have so far been overlooked. Read More

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