7,700 results match your criteria Toxicity Arsenic


Genetic, epigenetic, and developmental toxicity of Chironomus riparius raised in metal-contaminated field sediments: A multi-generational study with arsenic as a second challenge.

Sci Total Environ 2019 Apr 3;672:789-797. Epub 2019 Apr 3.

School of Environmental Engineering, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul 02504, Republic of Korea. Electronic address:

Ecotoxicity tests conducted under well-controlled lab conditions often do not reflect the real environmental conditions. To this end, we designed an ecotoxicity test using an aquatic midge, Chironomus riparius, raised in metal-contaminated field sediments (MCFS), which reflect the real environmental conditions, for five consecutive generations (F0-F4) followed by a toxic response to arsenic exposure (as a second challenge). The toxic responses (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.04.013DOI Listing
April 2019
1 Read

Rapid detection of heavy metal-induced toxicity in water using a fed-batch sulfur-oxidizing bacteria (SOB) bioreactor.

J Microbiol Methods 2019 Apr 9. Epub 2019 Apr 9.

Department of Biological Environment, Kangwon National University, 192-1 Hyoja-dong, Gangwon-do, Chuncheon-si 200-701, Republic of Korea. Electronic address:

A fed-batch bioreactor based on sulfur-oxidizing bacteria (SOB) was tested for rapid detection of heavy metal-induced toxicity in water. For this evaluation, SOB were exposed to water contaminated by selenium, mercury, hexavalent chromium, arsenic, cyanide, cadmium, and lead for 2 h and their inhibition rates were analyzed based on changes in electrical conductivity (EC). The results demonstrate that SOB were highly inhibited by selenium, mercury, hexavalent chromium, and arsenic but not by cyanide, cadmium, and lead. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mimet.2019.04.007DOI Listing
April 2019
1 Read

An assessment of arsenic hazard in groundwater-soil-rice system in two villages of Nadia district, West Bengal, India.

Environ Geochem Health 2019 Apr 8. Epub 2019 Apr 8.

Plant Stress Biology Laboratory, Institute of Environment and Sustainable Development (IESD), Banaras Hindu University (BHU), Varanasi, 221005, India.

The present study measured arsenic (As) concentrations in soil, groundwater and rice grain samples in two villages, Sarapur and Chinili, under Chakdaha block, Nadia district, West Bengal, India. This study also included a survey of the two villages to understand the knowledge among villagers about the As problem. Soil and groundwater samples were collected from fields in two villages while rice grain samples were collected from villagers' houses. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10653-019-00289-4
Publisher Site
http://dx.doi.org/10.1007/s10653-019-00289-4DOI Listing
April 2019
3 Reads

Self-enhanced and efficient removal of arsenic from waste acid using magnetite as an in situ iron donator.

Water Res 2019 Mar 29;157:269-280. Epub 2019 Mar 29.

State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization, Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming, 650093, China.

High arsenic-containing waste acid from the heavy nonferrous metallurgical sector (Cu, Pb, Zn, Ni, Sn, etc.), one of the most dangerous arsenic hazardous wastes with extremely high arsenic concentrations, has presented enormous challenges to the environment and caused severe environmental pollution over the past few decades due to the lack of affordable and environmentally friendly disposal technologies. Here, we report a green process for the self-enhanced and efficient removal of arsenic from waste acid using magnetite as an in situ iron donator. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00431354193021
Publisher Site
http://dx.doi.org/10.1016/j.watres.2019.03.067DOI Listing
March 2019
4 Reads

Nanobubble Technologies Offer Opportunities To Improve Water Treatment.

Acc Chem Res 2019 Apr 8. Epub 2019 Apr 8.

Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment, School of Sustainable Engineering and the Built Environment , Arizona State University , Tempe , Arizona 85287-5306 , United States.

Since first hypothesizing the existence of nanobubbles (NBs) in 1994, the empirical study of NB properties and commercialization of NB generators have rapidly evolved. NBs are stable spherical packages of gas within liquid and are operationally defined as having diameters less than 1000 nm, though they are typically in the range of 100 nm in one dimension. While theories still lack the ability to explain empirical evidence for formation of stable NBs in water, numerous NB applications have emerged in different fields, including water and wastewater purification where NBs offer the potential to replace or improve efficiency of current treatment processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.accounts.8b00606DOI Listing
April 2019
3 Reads

Natural variation in arsenic toxicity is explained by differences in branched chain amino acid metabolism.

Elife 2019 Apr 8;8. Epub 2019 Apr 8.

Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, United States.

We find that variation in the gene underlies natural differences in responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. We causally linked a non-synonymous variant in the conserved lipoyl domain of DBT-1 to differential arsenic responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.40260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453569PMC
April 2019
1 Read

An extracellular pH-driven targeted multifunctional manganese arsenite delivery system for tumor imaging and therapy.

Biomater Sci 2019 Apr 8. Epub 2019 Apr 8.

Center for Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China.

Expanding the use of arsenic trioxide (ATO, As2O3) in cancer chemotherapy has received extensive attention in recent years owing to its remarkable efficacy in treating acute promyelocytic leukemia (APL). To date, the use of ATO for clinical treatment of solid tumors is still limited by its poor biocompatibility and severe toxic side effects. To address these limitations, here we developed a pH-low insertion peptide (pHLIP) modified ATO-based multifunctional drug-delivery system (DDS), which is termed MnAs@SiO2-pHLIP. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C9BM00216B
Publisher Site
http://dx.doi.org/10.1039/c9bm00216bDOI Listing
April 2019
8 Reads

Removing arsenic from water by coprecipitation with iron: Effect of arsenic and iron concentrations and adsorbent incorporation.

Chemosphere 2019 Mar 26;226:431-438. Epub 2019 Mar 26.

Faculty of Engineering, University of Technology Sydney (UTS), P.O. Box 123, Broadway, NSW, 2007, Australia. Electronic address:

Arsenic (As) contamination of drinking water is a major cause of As toxicity in many parts of the world. A study was conducted to evaluate As removal from water containing 100-700 μg/L of As and As to Fe concentration ratios of 1:5-1:1000 using the coprecipitation process with and without As/Fe adsorption onto granular activated carbon (GAC). Fe concentration required to reduce As concentrations in order to achieve the WHO standard level of 10 μg/L increased exponentially with the increase in initial As concentration. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00456535193058
Publisher Site
http://dx.doi.org/10.1016/j.chemosphere.2019.03.142DOI Listing
March 2019
2 Reads

Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity.

Toxicol Lett 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmacy at the Second Affiliated Hospital, Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin 150086, China; The Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China; Department of Clinical Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China. Electronic address:

Arsenic trioxide (ATO) has been recommended as the first-line agent for the treatment ofacute promyelocytic leukaemia (APL), due to its substantial anticancer effect. Numerous clinical reports have indicated that ATO is a developmental toxicant which can result in birth defects of human beings. But whether arsenic trioxide can lead to human cardiac developmental toxicity remains largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.03.008DOI Listing
April 2019
3.262 Impact Factor

Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity.

Evid Based Complement Alternat Med 2019 10;2019:1697804. Epub 2019 Jan 10.

Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.

Minerals are alchemically processed as Bhasmas in Ayurvedic medicines or as Zuotai in Tibetan medicines. Ayurveda is a knowledge system of longevity and considers the mineral elixir made from "nature" capable of giving humans perpetual life. Herbo-metallic preparations have a long history in the treatment of various diseases in India, China, and around the world. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1697804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421027PMC
January 2019
1 Read

Nitric oxide alters nitrogen metabolism and PIN gene expressions by playing protective role in arsenic challenged Brassica juncea L.

Ecotoxicol Environ Saf 2019 Jul 26;176:95-107. Epub 2019 Mar 26.

Ecotoxicogenomics Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi, 25, India. Electronic address:

Plants have ability to adapt themselves through altering their growth process. In the present study, we examined exogenous application of nitric oxide (NO) on nitrogen metabolism and auxin (PIN) gene expression, and its possible role in alleviation of arsenic (As) toxicity in Brassica juncea seedlings. Seven days old hydroponically grown B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.03.054DOI Listing
July 2019
4 Reads

Fungal mediated biotransformation reduces toxicity of arsenic to soil dwelling microorganism and plant.

Ecotoxicol Environ Saf 2019 Jul 27;176:108-118. Epub 2019 Mar 27.

Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR Campus, Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India. Electronic address:

Rhizospheric and plant root associated microbes generally play a protective role against arsenic toxicity in rhizosphere. Rhizospheric microbial interaction influences arsenic (As) detoxification/mobilization into crop plants and its level of toxicity and burden. In the present investigation, we have reported a rhizospheric fungi Aspergillus flavus from an As contaminated rice field, which has capability to grow at high As concentration and convert soluble As into As particles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.03.053DOI Listing
July 2019
1 Read
2.762 Impact Factor

Involvement of glutathione metabolism in Eichhornia crassipes tolerance to arsenic.

Plant Biol (Stuttg) 2019 Mar 29. Epub 2019 Mar 29.

Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brasil.

1. Aquatic macrophytes are potential useful for phytoremediation programs in environments contaminated by arsenic (As). Biochemical and physiological modification analyses in different plant parts are important to understand As tolerance mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/plb.12988DOI Listing
March 2019
2 Reads

Arsenic removal from aqueous solutions and groundwater using agricultural biowastes-derived biosorbents and biochar: a column-scale investigation.

Int J Phytoremediation 2019 Mar 29:1-10. Epub 2019 Mar 29.

a Department of Environmental Sciences , COMSATS University Islamabad , Vehari Campus, Vehari , Pakistan.

In this study, column-scale laboratory experiments were performed to evaluate the arsenic (As) removal efficiency of different agricultural biowastes-derived biosorbents (orange peel, banana peel, rice husk) and biochar, using As-containing solutions and As-contaminated groundwater. All the biosorbents and biochar efficiently removed (50-100%) As from groundwater (drinking well water). Arsenic removal potential of biosorbents varied with their type, As concentration, contact time, and As solution type. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15226514.2018.1501340DOI Listing
March 2019
1 Read
1.739 Impact Factor

Biochar versus bone char for a sustainable inorganic arsenic mitigation in water: What needs to be done in future research?

Environ Int 2019 Mar 22;127:52-69. Epub 2019 Mar 22.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.

Arsenic (As) is an emerging contaminant on a global scale posing threat to environmental and human health. The relatively brief history of the applications of biochar and bone char has mapped the endeavors to remove As from water to a considerable extent. This critical review attempts to provide a comprehensive overview for the first time on the potential of bio- and bone-char in the immobilization of inorganic As in water. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2019.03.012DOI Listing
March 2019
6 Reads

The relative importance of waterborne and dietborne As exposure on survival and growth of juvenile fathead minnows.

Aquat Toxicol 2019 Mar 8;211:18-28. Epub 2019 Mar 8.

U.S. Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, MN, 55804, USA.

The survival and growth of juvenile fathead minnows were investigated at various combinations of waterborne exposure to arsenate and of dietborne exposure to oligochaete worms which had been exposed to inorganic arsenic. Previous work with rainbow trout established that dietborne arsenic can reduce fish growth at environmentally relevant concentrations and could be more important than waterborne exposures. This was found to be less true for fathead minnows, which were less sensitive to dietborne exposures than rainbow trout, while being as or more sensitive to waterborne exposures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.03.008DOI Listing
March 2019
1 Read

Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats.

Drug Chem Toxicol 2019 Mar 25:1-12. Epub 2019 Mar 25.

e Medicinal Plant Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Chronic exposure to toxic inorganic arsenic results in the adverse health effects including skin lesions, cardiovascular diseases, diabetes, neurological disorders, and liver and kidney diseases. Gallic acid (GA) is an important phenolic compound, which could protect different tissues from oxidative stress induced damage. The present study investigated effects of GA against sodium arsenite (SA)-induced renal and hepatic toxicity. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
Publisher Site
http://dx.doi.org/10.1080/01480545.2019.1591434DOI Listing
March 2019
3 Reads
1.098 Impact Factor

Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.

G3 (Bethesda) 2019 Mar 21. Epub 2019 Mar 21.

Texas A&M University

Trichloroethylene (TCE) and inorganic arsenic (iAs) are environmental contaminants that can target the kidney. Chronic exposure to TCE is associated with increased incidence of renal cell carcinoma, while co-exposure to TCE and iAs likely occurs in exposed human populations, such as those near Superfund sites. In order to better understand the kidney health consequences of TCE and/or iAs exposure, a genetically heterogeneous mouse population derived from FVB/NJ and CAST/EiJ mouse strains and deficient for multidrug resistance genes ( ) was chronically exposed for 52-weeks to varying concentrations of TCE and iAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/g3.119.400161DOI Listing
March 2019
1 Read

Current Perspective on Arsenic in Wines: Analysis, Speciation, and Changes in Composition during Production.

J Agric Food Chem 2019 Apr 3;67(15):4154-4159. Epub 2019 Apr 3.

Department of Viticulture and Technology , University of California , Davis , California 95616 , United States.

Arsenic, a naturally occurring metalloid found in certain foods, exists in various redox states and as inorganic and organic species, each with varying levels of toxicity. International regulatory bodies have imposed allowable maximums for total arsenic in wine ranging between 100 and 200 μg/L. Typical commercial wine levels are within these limits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.9b00634DOI Listing
April 2019
2 Reads

Presence of Toxic Heavy Metals in Platelet-Rich Fibrin: a Pilot Study.

Biol Trace Elem Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Geological Engineering, Faculty of Engineering, Kocaeli University, Kocaeli, Turkey.

Platelet-rich fibrin (PRF) is widely used blood-derived biomaterial which is directly applied to the surgical wounds. Depending on its autologous origin, PRF is thought as a safe material. However, it is not known to what extent the blood-derived toxins can be found in the PRF by considering the systemic exposure rates of the individuals to the toxins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12011-019-01695-6DOI Listing
March 2019
1 Read

A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh.

PLoS Genet 2019 03 20;15(3):e1007984. Epub 2019 Mar 20.

Department of Public Health Sciences, The University of Chicago, Chicago, IL, United States of America.

Inorganic arsenic (iAs) is a carcinogen, and exposure to iAs via food and water is a global public health problem. iAs-contaminated drinking water alone affects >100 million people worldwide, including ~50 million in Bangladesh. Once absorbed into the blood stream, most iAs is converted to mono-methylated (MMA) and then di-methylated (DMA) forms, facilitating excretion in urine. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pgen.1007984
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.1007984DOI Listing
March 2019
14 Reads

Characterization of arsenic oxidation and uranium bioremediation potential of arsenic resistant bacteria isolated from uranium ore.

Environ Sci Pollut Res Int 2019 Mar 19. Epub 2019 Mar 19.

Department of Microbiology, University of Kalyani, Kalyani, West Bengal, 741235, India.

Arsenic (As) is often found naturally as the co-contaminant in the uranium (U)-contaminated area, obstructing the bioremediation process. Although the U-contaminated environment harbors microorganisms capable of interacting with U which could be exploited in bioremediation. However, they might be unable to perform with their full potential due to As toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-019-04827-6DOI Listing
March 2019
5 Reads

Targeted Degradation of Glucose Transporters Protects Against Arsenic Toxicity.

Mol Cell Biol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

The abundance of cell surface glucose transporters must be precisely regulated to ensure optimal growth under constantly changing environmental conditions. We recently conducted a proteomic analysis of the cellular response to trivalent arsenic, a ubiquitous environmental toxin and carcinogen. A surprising finding was that a subset of glucose transporters were among the most downregulated proteins in the cell upon arsenic exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00559-18DOI Listing
March 2019
1 Read

Nitrate supplementation attenuates As(V) toxicity in Solanum lycopersicum L. cv Pusa Rohini: Insights into As(V) sub-cellular distribution, photosynthesis, nitrogen assimilation, and DNA damage.

Plant Physiol Biochem 2019 Mar 9;139:44-55. Epub 2019 Mar 9.

Assistant Professor, Department of Botany, University of Delhi, Delhi, 110007, India. Electronic address:

The present study investigates As(V) toxicity in tomato (Solanum lycopersicum L. cv Pusa Rohini) and its alleviation by exogenous supplementation of nitrate. The seven days old seedlings were grown up to thirty days under defined levels of As(V) concentrations (0, 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plaphy.2019.03.007DOI Listing
March 2019
2 Reads

The effects of arsenic speciation on accumulation and toxicity of dietborne arsenic exposures to rainbow trout.

Aquat Toxicol 2019 May 5;210:227-241. Epub 2019 Mar 5.

U.S. Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USA.

The effects on juvenile rainbow trout survival, growth, food consumption, and food conversion efficiency from dietborne exposures to inorganic arsenic (arsenite, arsenate) and to the organoarsenicals monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (AsB) were investigated in two experiments: (1) a 28-d exposure using live diets of oligochaete worms separately exposed via water to these five arsenic compounds and (2) a 56-d exposure using pellet diets prepared from commercial fish food to which arsenite, MMA, or DMA were added. In the live diet experiment, the degree to which worms could be contaminated with the organoarsenicals was limited by toxicity to the worms and other experimental constraints, so that their toxicity relative to inorganic arsenic could not be fully established, but AsB was concluded to have low toxicity, consistent with published results for mammals. For the pellet diet experiment, MMA and DMA were found to be at least an order of magnitude less toxic than inorganic As on the basis of concentration in the diet, as well as much less toxic on the basis of accumulation in the fish. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2019.03.001DOI Listing
May 2019
1 Read

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature.

Authors:
Iwona Zwolak

Biol Trace Elem Res 2019 Mar 15. Epub 2019 Mar 15.

Laboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, Konstantynów 1 J, 20-708, Lublin, Poland.

Arsenic (As) and cadmium (Cd) are elements arousing major public health concerns associated with environmental pollution, high toxicity potential, and carcinogenic nature. However, selenium (Se) at low doses and incorporated into enzymes and proteins has antioxidant properties and protects animals and humans from the risk of various diseases. It also has an exceptionally narrow range between necessary and toxic concentrations, which is a well-known hindrance in its use as a dietary supplement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12011-019-01691-wDOI Listing
March 2019
3 Reads

Arsenic removal using Chlamydomonas reinhardtii modified with the gene acr3 and enhancement of its performance by decreasing phosphate in the growing media.

Int J Phytoremediation 2019 Mar 15:1-7. Epub 2019 Mar 15.

a Laboratorio de Biorreactores, Facultad de Ciencias Químicas Universidad Autónoma de San Luis Potosí , San Luis Potosí , México.

Arsenic contamination of groundwater is a significant problem in countries like Mexico, where San Luis Potosi is among the regions registering severe levels of it. Bioremediation with microalgae capable to absorb and metabolize metals or metalloids like arsenic reduces their toxicity and is a cost-effective approach compared to physical-chemical processes. We evaluated the capability of Chlamydomonas reinhardtii to remove arsenate and compared it with an acr3-modified recombinant strain, which we produced by transforming the wild-type strain with Agrobacterium tumefaciens using the construct pARR1 including a synthetic, optimized acr3 gene from Pteris vittata, a hyper-accumulator of arsenic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15226514.2018.1546274DOI Listing
March 2019
1 Read
1.739 Impact Factor

Assessment of potential dietary toxicity and arsenic accumulation in two contrasting rice genotypes: Effect of soil amendments.

Chemosphere 2019 Mar 2;225:104-114. Epub 2019 Mar 2.

Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.

High concentration of arsenic (As) in rice is a serious problem worldwide. Pot experiments were conducted to assess the potential dietary toxicity of arsenic and effect of various soil amendments on arsenic accumulation in rice grains. Two basmati rice genotypes were used to conduct pot experiments using various levels of arsenic (10, 25, 50 and 100 mg kg soil). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.202DOI Listing
March 2019
2 Reads
3.340 Impact Factor

Speciation Analysis of Trace Arsenic, Mercury, Selenium and Antimony in Environmental and Biological Samples Based on Hyphenated Techniques.

Molecules 2019 Mar 7;24(5). Epub 2019 Mar 7.

Tianjin Key Laboratory of Marine Resources and Chemistry, College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, Tianjin 300457, China.

In order to obtain a well understanding of the toxicity and ecological effects of trace elements in the environment, it is necessary to determine not only the total amount, but also their existing species. Speciation analysis has become increasingly important in making risk assessments of toxic elements since the toxicity and bioavailability strongly depend on their chemical forms. Effective separation of different species in combination with highly sensitive detectors to quantify these particular species is indispensable to meet this requirement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24050926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429259PMC
March 2019
4 Reads

Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice.

Sci Total Environ 2019 Jun 2;668:310-317. Epub 2019 Mar 2.

Program of Environmental Toxicology, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

Although epidemiologic studies show an association between long-term environmental inorganic arsenic (iAs) exposure and various disorders of glucose and lipid metabolism, the mechanisms of these ailments remain unclear. While white adipose tissue (WAT) essentially acts as a storage tissue for energy and is key to energy homeostasis, brown adipose tissue (BAT) consumes excess energy via uncoupling protein 1-mediated non-shivering thermogenesis in mitochondria and helps maintain the steady state of glucose and lipid metabolism. Our previous in vitro work found that iAs may inhibit adipogenesis and glucose uptake in adipocytes, leading us to hypothesize that chronic exposure to iAs in vivo may also affect the development and function of BAT, which plays a part in iAs-induced metabolic disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.03.008DOI Listing
June 2019
3 Reads

Toxic effects of chemical warfare agent mixtures on the mussel Mytilus trossulus in the Baltic Sea: A laboratory exposure study.

Mar Environ Res 2019 Mar 7;145:112-122. Epub 2019 Feb 7.

Swedish Defence Research Agency, Cementvägen 20, 90182, Umeå, Sweden.

Baltic blue mussels (Mytilus trossulus) were implemented to assess potential toxicity, health impairments and bioaccumulation of dumped chemical warfare agents on marine benthic organisms. Mussels were collected from a pristine cultivation side and exposed under laboratory conditions to different mixtures of chemical warfare agents (CWAs) related phenyl arsenic compounds, Clark I and Adamsite as well as chloroacetophenone. Using a multi-biomarker approach, mussels were assessed thereafter for effects at different organisational levels ranging from geno-to cytotoxic effects, differences in enzyme kinetics and immunological responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.marenvres.2019.02.001DOI Listing
March 2019
2 Reads

Arsenic exposure intensifies glycogen nephrosis in diabetic rats.

Environ Sci Pollut Res Int 2019 Mar 7. Epub 2019 Mar 7.

Department of General Biology, Federal University of Viçosa, Av. P.H. Rolfs, s/n, Campus Universitário, Vicosa, Minas Gerais, 36570-900, Brazil.

It is known that either arsenic exposure or diabetes can impact renal function. However, it is unclear how these combined factors may influence kidney functions. Therefore, we evaluated morphological, functional, and oxidative parameters in the kidney of diabetic rats exposed to arsenic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-019-04597-1DOI Listing
March 2019
1 Read

A Review of Heavy Metal Contamination of Food Crops in Nigeria.

Ann Glob Health 2018 Aug 31;84(3):488-494. Epub 2018 Aug 31.

Department of Family Medicine, Irrua Specialist Teaching Hospital, NG.

Heavy metal contamination of food crops is an issue of global concern that ultimately results in toxicity and diseases in humans and animals through consumption of contaminated soils and food crops. With a population of 182 million people, Nigeria is regarded as the most populous country in Africa. The people suffer environmental pollution from high levels of heavy metal accumulation in the environment and in food crops. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29024/aogh.2314DOI Listing
August 2018
4 Reads

Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats.

Environ Sci Pollut Res Int 2019 Mar 5. Epub 2019 Mar 5.

Unit of Toxicology, Department of Zoology, Bharathiar University, Coimbatore, Tamilnadu, 641 046, India.

Oxidative stress plays a significant role in the pathophysiology of numerous kidney diseases, generally mediated by reactive oxygen species (ROS). Arsenic (Ar) is known to exert its toxicity through the generation of ROS and inflammation. The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-019-04502-wDOI Listing
March 2019
1 Read

Environmental and Genetic Factors Influencing Kidney Toxicity.

Authors:
Lawrence H Lash

Semin Nephrol 2019 Mar;39(2):132-140

Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI. Electronic address:

The kidneys are a frequent target organ for toxicity from exposures to various environmental chemicals and agents. To understand the risk to human health from such exposures, it is important to consider both the underlying chemical and pathologic mechanisms and factors that may modify susceptibility to injury. Choices of exemplary environmental agents to review are based on those with selective effects on the kidneys and for which significant amounts of mechanistic and human data are available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semnephrol.2018.12.003DOI Listing
March 2019
6 Reads

Green remediation of As and Pb contaminated soil using cement-free clay-based stabilization/solidification.

Environ Int 2019 May 28;126:336-345. Epub 2019 Feb 28.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

Stabilization/solidification (S/S) is a low-cost and high-efficiency remediation method for contaminated soils, however, conventional cement-based S/S method has environmental constraints and sustainability concerns. This study proposes a low-carbon, cement-free, clay-based approach for simultaneous S/S of As and Pb in the contaminated soil, and accordingly elucidates the chemical interactions between alkali-activated clay binders and potentially toxic elements. Quantitative X-ray diffraction and Al nuclear magnetic resonance analyses indicated that the addition of lime effectively activated the hydration of kaolinite clay, and the presence of limestone further enhanced the polymerization of hydrates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2019.02.057DOI Listing
May 2019
3 Reads

Arsenic and sulfur dioxide co-exposure induce renal injury via activation of the NF-κB and caspase signaling pathway.

Chemosphere 2019 Jun 18;224:280-288. Epub 2019 Feb 18.

School of Life Science, Shanxi University, Taiyuan, China. Electronic address:

Although emerging evidence suggests positive association of arsenic (As) or sulfur dioxide (SO) exposure with human diseases, reports concerning the effects of co-exposure of As and SO are lacking. Moreover, there is insufficient information in the literature about As and SO co-exposure to renal injury. In this study, we focus on the environmental problems of excessive As and SO that co-exist in many coal consumption areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.111DOI Listing
June 2019
2 Reads

Toxicity assessment of arsenic on common carp (Cyprinus carpio) and development of natural sorbents to reduce the bioconcentration by RSM methodology.

Chemosphere 2019 Jun 23;224:247-255. Epub 2019 Feb 23.

Department of Fisheries, Faculty of Natural Resources, University of Kurdistan, Sanandaj, Iran.

The objective of the present study was firstly acute toxicity bioassay of arsenic on common carp (Cyprinus carpio) and then the development of natural sorbent beds (clinoptilolite and pumice) to reduce bioconcentration of arsenic in muscle tissue were considered in comparative evaluation. In this regard, the acute toxicity of arsenic on juvenile fish was assessed according to the OECD guideline (No. 203). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.146DOI Listing
June 2019
1 Read
3.340 Impact Factor

Arsenic and fasting blood glucose in the context of other drinking water chemicals: a cross-sectional study in Bangladesh.

Environ Res 2018 Dec 21;172:249-257. Epub 2018 Dec 21.

Department of Environmental Health, Emory University, Atlanta, GA, USA; Department of Epidemiology, Emory University, Atlanta, GA, USA. Electronic address:

Goal: The goal of this study was to evaluate the association between groundwater arsenic and fasting blood glucose in the context of other groundwater chemicals, in Bangladesh.

Methods: Fasting blood glucose, gender, body mass index, sociodemographic variables, and diabetes medication use were measured among adults ≥ 35 years of age (n = 6587) participating in the Bangladesh Demographic and Health Survey (BDHS) 2011. Groundwater chemicals in 3534 well water samples were measured in the British Geological Survey (BGS) and Department of Public Health Engineering (DPHE) 1998-99 survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2018.12.049DOI Listing
December 2018
5 Reads

Transcriptomics analysis defines global cellular response of Agrobacterium tumefaciens 5A to arsenite exposure regulated through the histidine kinases PhoR and AioS.

Environ Microbiol 2019 Feb 27. Epub 2019 Feb 27.

Department of Land Resources and Environmental Sciences, Montana State University, Bozeman, MT 59717, USA.

In environments where arsenic and microbes coexist, microbes are the principal drivers of arsenic speciation, which directly affects bioavailability, toxicity and bioaccumulation. Speciation reactions influence arsenic behaviour in environmental systems, directly affecting human and agricultural exposures. Arsenite oxidation decreases arsenic toxicity and mobility in the environment, and therefore understanding its regulation and overall influence on cellular metabolism is of significant interest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1462-2920.14577DOI Listing
February 2019
1 Read

Functional profiling identifies determinants of arsenic trioxide cellular toxicity.

Toxicol Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida.

Arsenic exposure is a worldwide health concern associated with an increased risk of skin, lung and bladder cancer but arsenic trioxide (ATO; AsIII) is also an effective chemotherapeutic agent. The current use of AsIII in chemotherapy is limited to acute promyelocytic leukemia (APL). However, AsIII was suggested as a potential therapy for other cancer types including chronic myeloid leukemia (CML), especially when combined with other drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfz024DOI Listing
January 2019
3 Reads

Proanthocyanidins Antagonize Arsenic-Induced Oxidative Damage and Promote Arsenic Methylation through Activation of the Nrf2 Signaling Pathway.

Oxid Med Cell Longev 2019 20;2019:8549035. Epub 2019 Jan 20.

Department of Public Health, Medical College, Shihezi University, 832000 Xinjiang, China.

Purpose: To investigate the effects of grape seed proanthocyanidin extract (GSPE) on oxidative damage and arsenic (As) methylation and to clarify the role of Nrf2 in the process.

Methods: L-02 cells were treated with arsenic (25 M) and GSPE (10, 25, and 50 mg/L) for 24 h. Cell viability was analyzed by MTT assay. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/omcl/2019/8549035/
Publisher Site
http://dx.doi.org/10.1155/2019/8549035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360624PMC
March 2019
12 Reads

Brain acetylcholinesterase of three perciformes: From the characterization to the in vitro effect of metal ions and pesticides.

Ecotoxicol Environ Saf 2019 May 22;173:494-503. Epub 2019 Feb 22.

Universidade Federal Rural de Pernambuco (UFRPE), Departamento de Pesca e Aquicultura, Recife, Brazil.

Estuarine environments gather pollution from large regions including urban and industrial zones. The monitoring of environmental quality in these areas constitutes a real requirement for global sustainable development. Therefore, the aim of this study was to characterize the physicochemical and kinetic parameters of brain acetylcholinesterase (AChE) in the species Centropomus undecimalis, Diapterus auratus and Diapterus rhombeus and to assess the effects (in vitro) of pesticides and metal ions on their respective activities in order to investigate them as potential biomarkers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.02.047DOI Listing

A transcriptomic (RNA-seq) analysis of genes responsive to both cadmium and arsenic stress in rice root.

Sci Total Environ 2019 May 18;666:445-460. Epub 2019 Feb 18.

College of Life Sciences, South China Agricultural University, Guangzhou 510642, People's Republic of China. Electronic address:

Cadmium (Cd) and arsenic (As) are nonessential and toxic elements in rice that often occur together in contaminated paddy field soils. To understand whether rice has a common molecular response mechanism against Cd and As toxicity, 30-day seedlings (Oryza sativa L. indica) were exposed separately to Cd and As in hydroponic cultures for up to 7 days. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697193077
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2019.02.281DOI Listing
May 2019
7 Reads

Alterations of root architecture and cell wall modifications in Tilia cordata Miller (Linden) growing on mining sludge.

Environ Pollut 2019 Feb 14;248:247-259. Epub 2019 Feb 14.

Department of Chemistry, Poznań University of Life Sciences, Wojska Polskiego 75, 60-625, Poznań, Poland.

Trees are considered good candidates for phytoremediation of soils contaminated with trace elements (TE), e.g. mine tailings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.02.019DOI Listing
February 2019
1 Read

Time course of arsenic species in red blood cells of acute promyelocytic leukemia (APL) patients treated with single agent arsenic trioxide.

Expert Rev Clin Pharmacol 2019 Apr 11;12(4):371-378. Epub 2019 Mar 11.

b Department of Hematology , The First Affiliated Hospital of Harbin Medical University , Harbin , China.

Background: Arsenic trioxide (ATO) is widely applied to treat acute promyelocytic leukemia (APL). To elucidate metabolism and toxicity of arsenic, we analyzed time course of arsenic species in red blood cells (RBCs) of APL patients.

Methods: Nine APL patients received ATO (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17512433.2019.1586532DOI Listing

Editorial: Effects of metal contamination on ammonia-oxidizing microorganisms in a freshwater reservoir.

J Environ Sci (China) 2019 May;79:364-366

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton T6G 2G3, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jes.2019.02.005DOI Listing
May 2019
2 Reads

Strategies to inhibit arsenic trioxide-induced cardiotoxicity in acute promyelocytic leukemia.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Arsenic trioxide (ATO) is a drug commonly used for the treatment of acute promyelocytic leukemia (APL). Although ATO has been shown to cause significant improvement in patients, it is associated with serious side effects, which sometimes lead to the patient's death. In this review paper, we examine the reports of ATO-induced cardiotoxicity in APL patients and evaluate the strategies to reduce the incidence of such toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28292DOI Listing
February 2019
1 Read

Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis.

Food Chem Toxicol 2019 Apr 12;126:41-55. Epub 2019 Feb 12.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, India. Electronic address:

Arsenic contaminated drinking water consumption is a serious health issue around the world. Chronic inorganic arsenic exposure has been associated with respiratory dysfunctions. It exerts various detrimental effects, disrupting normal cellular homeostasis and turning on severe pulmonary complications. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02786915193007
Publisher Site
http://dx.doi.org/10.1016/j.fct.2019.02.022DOI Listing
April 2019
9 Reads
2.895 Impact Factor

Toward Candidate Proteomic Biomarkers in Clinical Monitoring of Acute Promyelocytic Leukemia Treatment with Arsenic Trioxide.

OMICS 2019 Feb;23(2):119-130

2 School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.

The introduction of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL) has resulted in high clinical complete remission (CR) rates over 90%. On the contrary, the risk for early death (ED) in APL patients treated with ATO continues to have a negative impact for optimization of APL therapeutics. There is an urgent need for precision medicine and biomarkers in clinical monitoring of ATO toxicity in APL, and ED in particular. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/omi.2018.0178DOI Listing
February 2019
1 Read