8,362 results match your criteria Toxicity Arsenic


Effect of Arsenic Stress on Expression Pattern of a Rice Specific at Various Developmental Stages and Their Allied Co-expression Target Networks.

Front Plant Sci 2020 16;11:752. Epub 2020 Jun 16.

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India.

In plants, arsenic (As) stress modulates metabolic cascades at various developmental stages by influencing the pattern of gene expressions mediated by small non-coding RNAs, especially Micro-RNAs, involved in the moderation of a myriad of cellular processes needed for plant adaptation upon oxidative stress. of gene family, involved mainly in the regulation of growth and development in plants. This study was designed to find out the role of arsenic toxicity on expression in all physiological growth stages. Read More

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http://dx.doi.org/10.3389/fpls.2020.00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308582PMC

[Analysis of Organoarsenic Compounds Concentration in Fish with the Newly Developed LC-MS/MS Method].

Shokuhin Eiseigaku Zasshi 2020 ;61(3):86-94

National Institute of Health Sciences.

Most fish contain some kinds of organoarsenic compounds. To assess the health risk for the chronic effects due to intake of these compounds, it is necessary to quantify the concentration of each chemical form, since the toxicity is difference depending on the form. We developed and validated the LC-MS/MS method to determine the concentration of monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), trimethylarsine oxide (TMAO), tetramethylarsonium (TeMA), arsenobetaine (AB), and arsenocholine (AC) in fish. Read More

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http://dx.doi.org/10.3358/shokueishi.61.86DOI Listing
January 2020

[Reconstructed Soil Vertical Profile Heavy Metal Cd Occurrence and Its Influencing Factors].

Huan Jing Ke Xue 2020 Jun;41(6):2878-2888

School of Earth and Environment, Anhui University of Science and Technology, Huainan 232001, China.

Aiming at the problem of heavy metal Cd pollution in mining wasteland under the high background value and superposition area of the historical mining source, a total of 30 samples were collected from the reclaimed soil of a historical sulfur mine in Southwest China. The total contents of Cadmium (Cd), Chromium (Cr), Nickel (Ni), Arsenic (As), and Mercury (Hg) in soil samples were analyzed. Scanning electron microscopy-electron diffraction spectroscopy (SEM-EDS) and BCR method for continuous extraction of heavy metals were used to analyze the occurrence of Cd under different soil thicknesses. Read More

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http://dx.doi.org/10.13227/j.hjkx.201911023DOI Listing

Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic-induced DNA damage and repair in normal human liver cells.

J Appl Toxicol 2020 Jul 1. Epub 2020 Jul 1.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, China.

Long-term arsenic exposure is a worldwide public health problem that causes serious harm to human health. The liver is the main target organ of arsenic toxicity; arsenic induces disruption of the DNA damage repair pathway, but its mechanisms remain unclear. In recent years, studies have found that epigenetic mechanisms play an important role in arsenic-induced lesions. Read More

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http://dx.doi.org/10.1002/jat.4026DOI Listing

Coexistence of diverse heavy metal pollution magnitudes: Health risk assessment of affected cattle and human population in some rural regions, Qena, Egypt.

J Adv Vet Anim Res 2020 Jun 10;7(2):345-359. Epub 2020 May 10.

Department of Biology, Faculty of Science, King Khalid University, Abha, Saudi Arabia.

Objective: The purpose of this study was to measure the mean concentrations of heavy metals including aluminum (Al), arsenic, nickel (Ni), mercury, lead (Pb), and cadmium (Cd) and to assess the health hazards due to the exposure of cattle/human population to a distinct or the mixture of heavy metals through various sources.

Materials And Methods: A total of 180 samples including water sources, animal feed, and raw cows' milk from rural regions in Qena, Egypt, were examined using the inductively coupled plasma emission spectrometer (ICP; iCAP 6200).

Results: The data highlighted heavy metal pollution with variable concentrations among most of the investigated regions. Read More

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http://dx.doi.org/10.5455/javar.2020.g428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320808PMC

Ecological risks of heavy metals/metalloid discharged from two sewage treatment works to Mai Po Ramsar site, South China.

Environ Monit Assess 2020 Jun 29;192(7):466. Epub 2020 Jun 29.

Consortium on Health, Environment, Education and Research (CHEER), and Department of Science and Environmental Studies, The Education University of Hong Kong, Tai Po, Hong Kong, People's Republic of China.

The concentrations of six heavy metal/metalloids (HMs) cadmium (Cd), copper (Cu), mercury (Hg), lead (Pb), zinc (Zn), and arsenic (As) were determined in the influent, effluent, and dewatered sludge of two sewage treatment works (Yuen Long Sewage Treatment Work (YLSTW) and Shek Wu Hui Sewage Treatment Work (SWHSTW)) and river waters and sediment (Shan Pui River and Ng Tung River) within the Mai Po Ramsar site in Hong Kong SAR, China. In both STWs, Pb had the highest removal efficiencies (YLSTW 86.5 ± 19. Read More

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http://dx.doi.org/10.1007/s10661-020-08397-wDOI Listing

In vitro administration of sodium arsenite in mouse prepubertal testis induces germ cell loss and apoptosis.

Toxicol In Vitro 2020 Jun 26:104924. Epub 2020 Jun 26.

University of Edinburgh, School of Biomedical Sciences, Edinburgh, United Kingdom.. Electronic address:

High levels of arsenic contamination in drinking water pose serious health risks in numerous countries. The documentation reporting arsenic toxicity on reproduction and development is increasing, with evidence of arsenic inducing fertility and developmental issues. Nonetheless, the impact of arsenic exposure on the development of the male reproductive system is not fully elucidated. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104924DOI Listing

[Russian multicenter clinical trials in acute leukemias].

Ter Arkh 2019 Jul 15;91(7):4-13. Epub 2019 Jul 15.

National Research Center for Hematology.

The paper describes the results of 15 consecutive Russian clinical trials in the treatment of different types of acute leukemias, conducted by Russian cooperative group within the last 27-years and included more than 25 hundred patients. It was shown that the 5-years overall survival in AML younger than 60 years patients improved from 20 to 33%, in ALL - from 38 to 65%, in APL - from 0 to 95%. The cooperative work resulted in balanced clinical recommendations and protocols, reproducible in regional hospitals. Read More

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http://dx.doi.org/10.26442/00403660.2019.07.000325DOI Listing

Dataset on leaching properties of coal ashes from Malaysian coal power plant.

Data Brief 2020 Aug 8;31:105843. Epub 2020 Jun 8.

Institute of Tropical Biodiversity and Sustainable Development, Universiti Malaysia Terengganu, 21300 Kuala Terengganu, Terengganu, Malaysia.

Coal combustion by-products (CCPs) (i.e. fly (FA) and bottom (BA) ashes) generated by power plants contain heavy metals. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306575PMC

Differential responses of photosynthetic parameters and its influence on carbohydrate metabolism in some contrasting rice (Oryza sativa L.) genotypes under arsenate stress.

Ecotoxicology 2020 Jun 27. Epub 2020 Jun 27.

Plant Physiology and Biochemistry Laboratory, Centre of Advanced Study, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, 700019, India.

Influence of arsenic (As) in As tolerant and sensitive rice genotypes based chloroplastic pigments, leaf gas exchange attributes and their influence on carbohydrate metabolism were investigated in the present study. As retards growth of crop plants and increase several health ailments by contaminating food chain. Photosynthetic inhibition is known to be the prime target of As toxicity due to over-production of ROS. Read More

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http://dx.doi.org/10.1007/s10646-020-02241-0DOI Listing

Toxicity of binary mixtures of Cu, Cr and As to the earthworm Eisenia andrei.

Ecotoxicology 2020 Jun 25. Epub 2020 Jun 25.

Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.

Chromated copper arsenate (CCA) mixtures were used in the past for wood preservation, leading to large scale soil contamination. This study aimed at contributing to the risk assessment of CCA-contaminated soils by assessing the toxicity of binary mixtures of copper, chromium and arsenic to the earthworm Eisenia andrei in OECD artificial soil. Mixture effects were related to reference models of Concentration Addition (CA) and Independent Action (IA) using the MIXTOX model, with effects being related to total and available (HO and 0. Read More

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http://dx.doi.org/10.1007/s10646-020-02240-1DOI Listing

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820937008

Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regimen for acute promyelocytic leukemia. Recently, there are interests in the use of the oral form of arsenic, named the Realgar-Indigo naturalis formula, but the data on its efficacy and safety are still relatively limited. Read More

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http://dx.doi.org/10.1177/1533033820937008DOI Listing

Dimethylarsinic acid is the causal agent inducing rice straighthead disease.

J Exp Bot 2020 May 15. Epub 2020 May 15.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China.

Straighthead disease is a physiological disorder in rice with symptoms of sterile spikelets, distorted husks, and erect panicles. Methylated arsenic species have been implicated as the causal agent of the disease, but direct evidence is lacking. Here, we investigated whether dimethylarsinic acid (DMA) causes straighthead disease and its effect on the transcriptome of young panicles. Read More

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http://dx.doi.org/10.1093/jxb/eraa253DOI Listing

Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic.

Environ Anal Health Toxicol 2020 Jun 24;35(2):2020006-0. Epub 2020 Jun 24.

Department of Internal Medicine, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Evidence suggests that the relationship between arsenic metabolism and diseases, including metabolic syndrome, is complex. The aim of this study was to evaluate the different types of arsenic methylation and its association with metabolic syndrome in an arsenic endemic area. A cross-sectional study was conducted on 132 subjects from Shahid-Abad Village, Qazvin province, Iran (arsenic endemic area). Read More

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http://dx.doi.org/10.5620/eaht.2020006DOI Listing

Counteracting arsenic toxicity: Curcumin to the rescue?

J Hazard Mater 2020 Jun 16;400:123160. Epub 2020 Jun 16.

Halal Research Center of IRI, FDA, Tehran, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Arsenicosis leads to various irreversible damages in several organs and is considered to be a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between pro- and antioxidant homeostasis, oxidative stress, as well as DNA and protein damage. Curcumin, the polyphenolic pigment extracted from the rhizome of Curcuma longa, is well-known for its pleiotropic medicinal effects. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123160DOI Listing

Synergistic ameliorative effect of iron oxide nanoparticles and S4 against arsenic toxicity in : polyamines, antioxidants, and physiochemical studies.

Int J Phytoremediation 2020 Jun 23:1-12. Epub 2020 Jun 23.

Senior Superintendent Garden, University of the Punjab, Lahore, Pakistan.

The present study was intended to assess the potential of iron oxide nanoparticles (IONPs) and S4 in mitigation of arsenic (As) stress in . seedlings were subjected to As stress for 60 days. Reduced level of growth parameters including photosynthetic pigments, rate of photosynthesis and gas exchange characteristics was observed in seedlings subjected to As stress. Read More

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http://dx.doi.org/10.1080/15226514.2020.1781052DOI Listing
June 2020
1.739 Impact Factor

The toxicology of gallium oxide in comparison with gallium arsenide and indium oxide.

Authors:
Ernst M Bomhard

Environ Toxicol Pharmacol 2020 Jun 19;80:103437. Epub 2020 Jun 19.

REACh ChemConsult GmbH, Strehlener Str. 14, D-01069 Dresden, Germany. Electronic address:

Gallium arsenide (GaAs) and indium oxide (InO) are used in electronic industries at high and increasing tonnages since decades. Gallium oxide (GaO) is an emerging wide-bandgap transparent conductive oxide with as yet little industrial use. Since GaAs has received critical attention due to the arsenic ion, it seemed reasonable to compare its toxicology with the respective endpoints of GaO and InO toxicology in order to find out if and to what extent arsenic contributes. Read More

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http://dx.doi.org/10.1016/j.etap.2020.103437DOI Listing

Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep.

Environ Sci Pollut Res Int 2020 Jun 21. Epub 2020 Jun 21.

Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India.

Chronic arsenic poisoning is one of the serious health hazards in West Bengal, India, and Bangladesh. It occurs due to contaminated subsoil water. The aim of this study is conducted to find out the ameliorative effect of turmeric and P. Read More

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http://dx.doi.org/10.1007/s11356-020-09569-4DOI Listing

Epigenetic alteration of mitochondrial biogenesis regulatory genes in arsenic exposed individuals (with and without skin lesions) and in skin cancer tissues: A case control study.

Chemosphere 2020 Jun 5;258:127305. Epub 2020 Jun 5.

Department of Environmental Science, University of Calcutta, Kolkata, 700019, India. Electronic address:

Chronic arsenic toxicity has become a global concern due to its adverse pathophysiological outcome and carcinogenic potential. It is already established that arsenic induced reactive oxygen species alters mitochondrial functionality. Major regulatory genes for mitochondrial biogenesis, i. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127305DOI Listing

Simultaneous removal and oxidation of arsenic from water by δ-MnO modified activated carbon.

J Environ Sci (China) 2020 Aug 30;94:147-160. Epub 2020 Apr 30.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.

The ubiquitous arsenic in groundwater poses a great risk to human health due to its environmental toxicity and carcinogenicity. In the present work, a new adsorbent, δ-MnO modified activated carbon, was prepared, and its performance for the uptake of arsenate and arsenite species from aqueous solutions was investigated by batch experiments. Various techniques, including FESEM-EDX, p-XRD, XPS and BET surface area analysis, were employed to characterize the properties of the adsorbent and the arsenic adsorption mechanisms. Read More

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http://dx.doi.org/10.1016/j.jes.2020.03.006DOI Listing

Alternative Method for the Treatment of Hydrometallurgical Arsenic-Calcium Residues: The Immobilization of Arsenic as Scorodite.

ACS Omega 2020 Jun 28;5(22):12979-12988. Epub 2020 May 28.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.

Arsenic-calcium residue (ACR) is one of the major hazardous solid wastes produced by the metallurgical industry that poses a serious threat to the environment. However, a suitable method for the effective treatment of ACR is still lacking. In this study, an alternative treatment method for ACRs via the immobilization of As as scorodite was proposed with the use of two types of ACRs (ACR directly collected from a Pb refinery and ACR precipitated from waste sulfuric acid in the lab). Read More

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http://dx.doi.org/10.1021/acsomega.0c00849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288567PMC

Zinc exerts its renal protection effect on arsenic-exposed common carp: A signaling network comprising Nrf2, NF-κB and MAPK pathways.

Fish Shellfish Immunol 2020 Jun 13;104:383-390. Epub 2020 Jun 13.

College of Wildlife and Protected Area, Northeast Forestry University, Harbin, 150040, Heilongjiang, PR China. Electronic address:

Epidemiological and laboratory investigations have extensively indicated that arsenic exposure accounts for several kidney diseases. Zinc has been suggested as a possible natural preventive and therapeutic agent. This study is designed to explore the beneficial effect of zinc supplementation against arsenic-induced renal toxicity in common carp, and the results point to signaling pathway possibly compromised. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.06.031DOI Listing

Biomononitoring of environmental exposure to inorganic arsenic.

Ann Biol Clin (Paris) 2020 Jun;78(3):279-298

Société de toxicologie clinique (STC).

Background And Objectives: The French national authority for health (Haute autorité de santé: HAS) and the French clinical toxicology society (Société de toxicologie clinique: STC) received a formal request from the French ministry for heath to elaborate recommendations for the screening of environmental overexposure to inorganic arsenic (iAs), for the medical management of overexposed patients and for the medical surveillance of exposed population. To allow these recommendations, preliminary literature retrieval and analysis were performed for identifying validated indicators of both exposure and early effects of iAs and their levels in the general population living in France.

Methods: Evaluations of inorganic arsenic toxicity conducted by national or international health agencies during the last 3 decades were all examined and analyzed. Read More

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http://dx.doi.org/10.1684/abc.2020.1550DOI Listing

LncRNA UCA1 Antagonizes Arsenic-Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression.

Adv Sci (Weinh) 2020 Jun 13;7(11):1903630. Epub 2020 Apr 13.

State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China.

Arsenic (As) is a widespread metalloid contaminant, and its internal exposure is demonstrated to cause serious detrimental health problems. Albeit considerable studies are performed to interrogate the molecular mechanisms responsible for As-induced toxicities, the exact mechanisms are not fully understood yet, especially at the epigenetic regulation level. In the present study, it is identified that long non-coding RNA (lncRNA) urothelial cancer associated 1 (UCA1) alleviates As-induced G2/M phase arrest in human liver cells. Read More

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http://dx.doi.org/10.1002/advs.201903630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284218PMC

'Prodrug-Like' Acetylmannosamine Modified Liposomes Loaded with Arsenic Trioxide for the Treatment of Orthotopic Glioma in Mice.

J Pharm Sci 2020 Jun 11. Epub 2020 Jun 11.

Department of Pharmacology, Harbin Medical University, 157 Baojian Road, Harbin, China. Electronic address:

Glioma is one of the fatal intracranial cancers that is a huge challenge to decrease the death rate currently. The deep penetration and high accumulation of therapeutic inorganic ions into the tumor site are extremely impeded due to the existence of physiological barriers, which limits to widen the indication of some drugs such as arsenic trioxide. The previous data have confirmed that the mannose substrate (MAN) without acetyl groups facilitates vesicles to go into the brain. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.06.001DOI Listing

Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon.

J Trace Elem Med Biol 2020 May 24;61:126563. Epub 2020 May 24.

University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany. Electronic address:

Arsenolipids, especially arsenic-containing hydrocarbons (AsHC), are an emerging class of seafood originating contaminants. Here we toxicologically characterize a recently identified oxo-AsHC 332 metabolite, thioxo-AsHC 348 in cultured human liver (HepG2) cells. Compared to results of previous studies of the parent compound oxo-AsHC 332, thioxo-AsHC 348 substantially affected cell viability in the same concentration range but exerted about 10-fold lower cellular bioavailability. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126563DOI Listing

Assessment of arsenic-induced modifications in the DNA methylation of insulin-related genes in rat pancreatic islets.

Ecotoxicol Environ Saf 2020 Jun 9;201:110802. Epub 2020 Jun 9.

Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), and Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address:

Extended exposure to inorganic arsenic through contaminated drinking water has been linked with increased incidence of diabetes mellitus. The most common exposure occurs through the consumption of contaminated drinking water mainly through geogenic sources of inorganic arsenic. Epigenetic modifications are important mechanisms through which environmental pollutants could exert their toxic effects. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110802DOI Listing
June 2020
2.762 Impact Factor

Salicylic acid-induced nitric oxide enhances arsenic toxicity tolerance in maize plants by upregulating the ascorbate-glutathione cycle and glyoxalase system.

J Hazard Mater 2020 May 26;399:123020. Epub 2020 May 26.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Botany, S.P. College Srinagar, Jammu and Kashmir, India. Electronic address:

The role of nitric oxide (NO) in salicylic acid (SA)-induced tolerance to arsenic (As) stress in maize plants is not reported in the literature. Before starting As stress (AsS) treatments, SA (0.5 mM) was sprayed to the foliage of maize plants. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123020DOI Listing

Studies of selenium and arsenic mutual protection in human HepG2 cells.

Chem Biol Interact 2020 Jun 7;327:109162. Epub 2020 Jun 7.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; Membrane Protein Disease Research Group, University of Alberta, Edmonton, Alberta, Canada; Department of Physiology, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Hundreds of millions of people worldwide are exposed to unacceptable levels of carcinogenic inorganic arsenic. Animal models have shown that selenium and arsenic are mutually protective through the formation and elimination of the seleno-bis(S-glutathionyl) arsinium ion [(GS)AsSe]. Consistent with this, human selenium deficiency in arsenic-endemic regions is associated with arsenic-induced disease, leading to the initiation of human selenium supplementation trials. Read More

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http://dx.doi.org/10.1016/j.cbi.2020.109162DOI Listing

Melatonin and calcium function synergistically to promote the resilience through ROS metabolism under arsenic-induced stress.

J Hazard Mater 2020 May 15;398:122882. Epub 2020 May 15.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 2455, Saudi Arabia.

The interplay between melatonin (Mel) and calcium (Ca) in enhancing tolerance to metalloid toxicity and underlying physiological and biochemical mechanisms of this relationship still remains unknown. The present study reveals that the signaling molecules Mel and/or Ca enhanced tolerance of Vicia faba (cv. Tara) plant to metalloid arsenic (As) toxicity. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122882DOI Listing
May 2020
4.529 Impact Factor

Validating the use of a toxicity database for prediction of plant cover and biodiversity in multi-metal mining impacted soils.

Environ Toxicol Chem 2020 Jun 5. Epub 2020 Jun 5.

Division of Soil and Water Management, Katholieke Universiteit Leuven, Kastelpark Arenberg 20, BE-3001, Leuven, Heverlee, Belgium.

The validity of soil toxicity databases for predicting ecological impacts in the field is rarely explored. This work was set up to test if laboratory toxicity data and the combined concepts of metal availability and mixture toxicity can predict ecological impact in mining-affected soils. Metal and arsenic (As) contamination gradients were sampled around five different mines in Mexico where plant cover and abundances exhibited clear dose-related responses. Read More

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http://dx.doi.org/10.1002/etc.4795DOI Listing

Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide.

Int J Mol Sci 2020 May 31;21(11). Epub 2020 May 31.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Background: Accumulating public health and epidemiological literature support the hypothesis that arsenic in drinking water or food affects the brain adversely.

Methods: Experiments on the consequences of nitric oxide (NO) formation in neuronal cell culture and mouse brain were conducted to probe the mechanistic pathways of nitrosative damage following arsenic exposure.

Results: After exposure of mouse embryonic neuronal cells to low doses of sodium arsenite (SA), we found that Ca was released leading to the formation of large amounts of NO and apoptosis. Read More

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http://dx.doi.org/10.3390/ijms21113948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312481PMC

Exogenous application of methyl jasmonate alleviates arsenic toxicity by modulating its uptake and translocation in rice (Oryza sativa L.).

Ecotoxicol Environ Saf 2020 May 29;201:110735. Epub 2020 May 29.

Molecular Biology and Biotechnology Division, Council of Scientific & Industrial Research-National Botanical Research Institute (CSIR-NBRI), Lucknow, 226001, India. Electronic address:

Methyl jasmonate (Me-JA) is a plant growth regulator known for modulating plant responses to various abiotic and biotic stresses. The unavoidable arsenic (As) contamination in rice (Oryza sativa) results in reduced crop yield and greater carcinogenic risk to humans. The present work examines the significance of Me-JA induced molecular signaling and tolerance towards arsenic toxicity in rice. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110735DOI Listing

Effects of Selenium on Arsenic-Induced Liver Lesions in Broilers.

Biol Trace Elem Res 2020 May 31. Epub 2020 May 31.

College of Veterinary Medicine, Sichuan Province Key Laboratory of Animal Disease & Human Health; Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an, 625014, China.

The aim of the present study was to investigate the abilities of selenium to counteract the toxic damage of arsenic (As). Two hundred 1-day-old healthy male broilers were randomly divided into five groups and fed the following diets: control group (0.1 mg/kg As + 0. Read More

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http://dx.doi.org/10.1007/s12011-020-02222-8DOI Listing

Is arsenic responsible for the toxicity of the hyperaccumulating mushroom Sarcosphaera coronaria?

Sci Total Environ 2020 Sep 22;736:139524. Epub 2020 May 22.

Institute of Chemistry, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria. Electronic address:

The Violet Crown Cup, Sarcosphaera coronaria, is a rather inconspicuous mushroom, but with an interesting and unresolved mystery. In earlier days, the mushroom was considered edible, but several poisonings were reported in the early 20 century. The reason for the seemingly sporadic toxicity of S. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139524DOI Listing
September 2020

Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models.

Chemosphere 2020 Oct 24;256:127204. Epub 2020 May 24.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, PR China. Electronic address:

The digestive tract is an important target organ for microplastics (MPs). However, little is known about the effects of digestive treatment on the intestinal toxicity of MPs. In this study, an in vitro digestive process was applied to transform 100 nm and 5 μm polystyrene microplastics (PS-MPs). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127204DOI Listing
October 2020
3.340 Impact Factor

Impacts of the Samarco tailing dam collapse on metals and arsenic concentration in freshwater fish muscle from Doce River, southeastern Brazil.

Integr Environ Assess Manag 2020 May 29. Epub 2020 May 29.

Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, MG, Brazil.

On November 2015, Samarco tailings dam in Mariana MG, Brazil, collapsed, releasing 62 million tons of tailings that advanced through 668 km of the Doce River and adjacent floodplain. Although being the worst environmental disaster in Brazil, little is known about consequences to aquatic biota. Here we evaluate the effects of the tailings mudflow on metal and arsenic concentration in fish and how concentration correlates with water and fish characteristics. Read More

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http://dx.doi.org/10.1002/ieam.4289DOI Listing

Curcumin alleviates arsenic-induced toxicity in PC12 cells via modulating autophagy/apoptosis.

Ecotoxicol Environ Saf 2020 Sep 25;200:110756. Epub 2020 May 25.

Graduate School of Environmental Science, Hokkaido University, Sapporo, 060-0810, Japan; Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan. Electronic address:

Arsenic is a recognized highly toxic contaminant, responsible for numerous human diseases and affecting many millions of people in different parts of the world. Contrarily, curcumin is a natural dietary polyphenolic compound and the main active ingredient in turmeric. Recently it has drawn great attention due to its diverse biological activities, strong antioxidant properties and therapeutic potential against many human ailments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110756DOI Listing
September 2020
2.762 Impact Factor

Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice.

Sci Total Environ 2020 Sep 19;734:139233. Epub 2020 May 19.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China. Electronic address:

Arsenic (As) poisoning and its potential reproductive functional lesions are a global environmental concern. Recent studies shown that spermiogenesis tends to be a major target process in arsenic-induced male infertility, however, the underlying mechanisms are not fully illuminated. In the present study, 32 fertility related indices including sperm motility, dynamic acrosome formation and sperm flagellum during spermiogenesis in testes were evaluated in adult male mice treated with 0, 0. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139233DOI Listing
September 2020
4.099 Impact Factor

Toxicological assessment of arsenic-containing phosphatidylcholines in HepG2 cells.

Metallomics 2020 May 27. Epub 2020 May 27.

Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Nuthetal, 14558, Germany. and TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.

Arsenolipids include a wide range of organic arsenic species that occur naturally in seafood and thereby contribute to human arsenic exposure. Recently arsenic-containing phosphatidylcholines (AsPCs) were identified in caviar, fish, and algae. In this first toxicological assessment of AsPCs, we investigated the stability of both the oxo- and thioxo-form of an AsPC under experimental conditions, and analyzed cell viability, indicators of genotoxicity and biotransformation in human liver cancer cells (HepG2). Read More

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http://dx.doi.org/10.1039/d0mt00073fDOI Listing

Phytoremediation Potential, Photosynthetic and Antioxidant Response to Arsenic-Induced Stress of L. Sown on Fly Ash Deposits.

Plants (Basel) 2020 May 22;9(5). Epub 2020 May 22.

Department of Ecology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.

Arsenic (As) from coal fly ash can be released into soil/groundwater, presenting a global threat to the environment and human health. To overcome this environmental problem, phytoremediation represents an urgent need, providing 'green' cleanup of contaminated lands. The present study focused on As concentrations in fly ash and plants, evaluation of phytoremediation potential of sown on fly ash deposits together with its photosynthetic activity, and oxidative and antioxidative response to As stress. Read More

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http://dx.doi.org/10.3390/plants9050657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284476PMC

Impact of heavy metals on the formation and properties of solvable microbiological products released from activated sludge in biological wastewater treatment.

Water Res 2020 Jul 7;179:115895. Epub 2020 May 7.

State Key Laboratory of Eco-hydraulics in Northwest Arid Region, Xi'an University of Technology, Xi'an, 710048, China. Electronic address:

This study investigated the acute impact of heavy metals on activated sludge with respect to the amount properties of biopolymers and other solvable microbiological products (SMPs) released from the sludge. Ten heavy metals were selected for the evaluation. Under the experimental conditions, exposing activated sludge to different metals led to an increase in SMPs, with a more significant increase in nitrogenous organics than in carbonaceous ones, where Hg, Ag, Cu, and Cr led to the highest increase in SMP species, while Cd, Ni, Mn, Pb, and Co caused limited increase in the middle and small SMP molecules, and Zn and Cr resulted in a decrease in SMP content. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115895DOI Listing

Arsenic phytovolatilization and epigenetic modifications in Arundo donax L. assisted by a PGPR consortium.

Chemosphere 2020 Jul 27;251:126310. Epub 2020 Feb 27.

Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano, SA, Italy.

Arsenic-(As) pollution is an increasing threat across the globe and it is reaching harmful values in several areas of the world. In this perspective, we assayed bio-phyto-remediation technology using Arundo donax L., assisted by Plant Growth Promoting Bacteria (PGPB) consortium (BC) constituted of two strains of Stenotrophomonas maltophilia sp. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126310DOI Listing

Clinicopathological Correlates: Chronic Arsenic Toxicity Causing Bilateral Symmetric Progressive Optic Neuropathy.

J Neuroophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Departments of Ophthalmology and Vision Sciences (PF, EM), and Medical Imaging (LA-S), Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Biomedical Physics (GM), Ryerson University, Toronto, Canada; Department of Laboratory Medicine (DH), University of Toronto, Toronto, Canada.

A 70 year-old man presented with insidiously progressing central visual acuity loss in both eyes over several years. Objectively the only abnormality identified on the exam was questionable granularity in the fovea in each eye. Extensive work up which included neuro-imaging, screening blood work for toxic and nutritional causes of optic neuropathy as well as electroretinogram and fluorescein angiography to rule out subtle maculopathy was all unrevealing. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000961DOI Listing

Arsenic in the rock-soil-plant system and related health risk in a magmatic-metamorphic belt, West of Iran.

Environ Geochem Health 2020 May 21. Epub 2020 May 21.

Department of Earth Sciences, University of Western Ontario, 1151 Richmond St, London, ON, N6A 5B7, Canada.

Following earlier reports of water contamination and arsenic (As) toxicity symptoms in residents of Kurdistan Province, As was determined in rock, soil and plant samples to investigate its fate from rock to crops and its potential effects on human health. Total As content ranged from 4.9 to 10,000 mg/kg, 7. Read More

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http://dx.doi.org/10.1007/s10653-020-00599-yDOI Listing
May 2020
2.566 Impact Factor

Global threat of arsenic in groundwater.

Science 2020 05;368(6493):845-850

Department of Water Resources and Drinking Water, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.

Naturally occurring arsenic in groundwater affects millions of people worldwide. We created a global prediction map of groundwater arsenic exceeding 10 micrograms per liter using a random forest machine-learning model based on 11 geospatial environmental parameters and more than 50,000 aggregated data points of measured groundwater arsenic concentration. Our global prediction map includes known arsenic-affected areas and previously undocumented areas of concern. Read More

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http://dx.doi.org/10.1126/science.aba1510DOI Listing

Characterization of Nitrate-Dependent As(III)-Oxidizing Communities in Arsenic-Contaminated Soil and Investigation of Their Metabolic Potentials by the Combination of DNA-Stable Isotope Probing and Metagenomics.

Environ Sci Technol 2020 Jun 2;54(12):7366-7377. Epub 2020 Jun 2.

Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Guangdong Institute of Eco-environmental Science & Technology, Guangdong Academy of Sciences, Guangzhou 510650, China.

Arsenite (As(III)) oxidation has important environmental implications by decreasing both the mobility and toxicity of As in the environment. Microbe-mediated nitrate-dependent As(III) oxidation (NDAO) may be an important process for As(III) oxidation in anoxic environments. Our current knowledge of nitrate-dependent As(III)-oxidizing bacteria (NDAB), however, is largely based on isolates, and thus, the diversity of NDAB may be underestimated. Read More

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http://dx.doi.org/10.1021/acs.est.0c01601DOI Listing

Titanium nanoparticles attenuates arsenic toxicity by up-regulating expressions of defensive genes in Vigna radiata L.

J Environ Sci (China) 2020 Jun 20;92:18-27. Epub 2020 Feb 20.

School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur 492 010, India. Electronic address:

Arsenic (As)-toxicity is recognized as one of the major environmental problems, affecting productivity of crops worldwide, thereby threatening sustainable agriculture and food security. Progression in nanotechnology and its impacts have brought up concerns about the application of engineered nanoparticles (NPs) in various sectors of the economy, including the field of agronomy. Among various NPs, there has been a rising amount of interest regarding the effects of titanium NPs (TiNPs) on plants growth and development, and their fate of abiotic stress tolerance. Read More

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http://dx.doi.org/10.1016/j.jes.2020.02.013DOI Listing

Effects of the joint application of phosphate rock, ferric nitrate and plant ash on the immobility of As, Pb and Cd in soils.

J Environ Manage 2020 Jul 13;265:110576. Epub 2020 Apr 13.

College of Chemistry and Chemical Engineering, Anhui University, Hefei, 230601, China; Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Wushan, Guangzhou, 510640, China; CAS Key Laboratory of Renewable Energy, Guangzhou, 510640, China; Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou, 510640, China. Electronic address:

Phosphate rock (PR) and ferric salts have been frequently used to immobilize heavy metal(loid)s in soils, but in varied efficiencies referring to different metal(loid) pollutants. This study explored the effective application of plant ash (PA) to the previous formula of phosphate rock (PR) and ferric salts (Fe(NO)) (PR + Fe+PA), compared to only PR, on the bioavailability and immobility of multi-metal(loid)s of selected arsenic (As), lead (Pb) and cadmium (Cd) in soils. Results from NaHCO- extraction and toxicity characteristic leaching procedure (TCLP) implied the increase of the As mobility in soils by 7. Read More

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http://dx.doi.org/10.1016/j.jenvman.2020.110576DOI Listing