5,402 results match your criteria Toxicity Antidepressants


Application of Pleurotus ostreatus to efficient removal of selected antidepressants and immunosuppressant.

J Environ Manage 2020 Aug 7;273:111131. Epub 2020 Aug 7.

Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy, Medical University of Warsaw, Mazovia, Poland. Electronic address:

Disposed pharmaceuticals constitute a significant threat to the environment due to the high consumption of drugs and inefficient treatment of wastewater. In this paper, we first described the efficient removal of a series of antidepressants and immunosuppressant from a cultivation medium carried out by white-rot fungus, Pleurotus ostreatus. We determined the removal efficiency of pharmaceuticals and the activity of fungal ligninolytic enzymes over time, as well as the toxicity of pre- and post-cultivation medium to Spirostomum ambiguum. Read More

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http://dx.doi.org/10.1016/j.jenvman.2020.111131DOI Listing

Pediatric Emergency Medicine Didactics and Simulation (PEMDAS): Serotonin Syndrome.

MedEdPORTAL 2020 Jul 28;16:10928. Epub 2020 Jul 28.

Assistant Professor, Department of Pediatrics, Division of Emergency Medicine, University of Washington School of Medicine and Seattle Children's Hospital.

Introduction: Serotonin syndrome is caused by an accumulation of serotonin in the body from drug interactions or overdose of serotonergic medications, including commonly used antidepressants. Symptoms can be life-threatening and encompass both neurologic and cardiovascular toxicity, including agitation, seizure, tachycardia, rhabdomyolysis, and hyperthermia.

Methods: This simulation case was developed for pediatric emergency medicine fellows and emergency medicine residents in the pediatric emergency department and can be altered to accommodate other learners. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385927PMC

Lithium toxicity with prolonged neurologic sequelae following sleeve gastrectomy: A case report and review of literature.

Medicine (Baltimore) 2020 Jul;99(28):e21122

Division of Pediatric Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan (R.O.C.).

Rationale: Lithium is the first-line medication for bipolar disorder, given a narrow therapeutic window of 0.8 to 1.2 mEq/L. Read More

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http://dx.doi.org/10.1097/MD.0000000000021122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360221PMC
July 2020
5.723 Impact Factor

The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study.

BMC Pharmacol Toxicol 2020 Jun 29;21(1):47. Epub 2020 Jun 29.

Department of Internal Medicine, Hadassah-Hebrew University Medical School, Mt Scopus, POB 24035, Ein Kerem, 91240, Jerusalem, Israel.

Background: In acute intoxication, carbamazepine concentration above 40 mcg/ml is associated with a risk of severe neurological consequences, including depressed consciousness, respiratory depression, cardiac conduction disorders, seizures, and death. Carbamazepine intoxication is often associated with the use of concomitant medications. However, the effect of exposure to other central-nervous-system (CNS) acting medications on the neurological manifestations of carbamazepine toxicity has not been evaluated. Read More

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http://dx.doi.org/10.1186/s40360-020-00425-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325050PMC

Insights on the metabolization of the antidepressant venlafaxine by meagre (Argyrosomus regius) using a combined target and suspect screening approach.

Sci Total Environ 2020 Oct 15;737:140226. Epub 2020 Jun 15.

Catalan Institute for Water Research (ICRA), C. Emili Grahit 101, 17003 Girona, Spain; Universitat de Girona, Girona, Spain.

Bioaccumulation of pharmaceuticals in fish exposed to contaminated water can be shaped by their capability to metabolize these xenobiotics, affecting their toxicity and animal welfare. In this study the in vivo metabolization of the antidepressant venlafaxine by the juvenile marine fish meagre (Argyrosomus regius) was evaluated using a combined target and suspect screening analytical approach. Thirteen venlafaxine metabolites were identified, namely N-desmethylvenlafaxine and N,N-didesmethylvenlafaxine, which were unequivocally identified using analytical standards, and 11 more tentatively identified by suspect screening analysis, including two Phase II metabolites formed by amino acid conjugation. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140226DOI Listing
October 2020

Characteristics of tianeptine effects reported to a poison control center: a growing threat to public health.

Clin Toxicol (Phila) 2020 Jun 18:1-6. Epub 2020 Jun 18.

Office of Medical Toxicology, Department of Emergency Medicine, University of Alabama-Birmingham, Birmingham, USA.

Tianeptine is an antidepressant structurally similar to tricyclic antidepressants which is approved abroad but is currently a drug of abuse in the United States since at least 2000. In 2019, our poison center experienced an increase in calls relating to this xenobiotic. The goal of this report is to describe the characteristics of acute tianeptine intoxication and withdrawal. Read More

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http://dx.doi.org/10.1080/15563650.2020.1781151DOI Listing

Characteristics and circumstances of death related to the self-administration of ketamine.

Addiction 2020 Jun 13. Epub 2020 Jun 13.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.

Background And Aims: Ketamine is used for anaesthesia, sedation and the treatment of mood disorders, but is also widely used for non-medical purposes. This study aimed to: (1) determine the characteristics and circumstances of all recorded cases of self-administered ketamine-related death in Australia, 2000-19 and (2) determine the toxicology and major organ pathology of cases.

Design: Retrospective study of all Australian cases in which self-administered ketamine was a mechanism contributory to death, retrieved from the National Coronial Information System. Read More

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http://dx.doi.org/10.1111/add.15154DOI Listing

Factors associated with fatigue in breast cancer patients undergoing external beam radiation therapy.

Pract Radiat Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: Cancer-related fatigue (CRF), a prevalent symptom among cancer patients, is a side effect of external beam radiotherapy (EBRT). Even when targeting organs unrelated to caloric intake or the CNS, radiotherapy can increase CRF, a poorly understood toxicity resulting from patient-specific, systemic therapy-related, and radiation-specific factors. We sought to determine factors associated with fatigue among patients receiving EBRT for breast cancer. Read More

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http://dx.doi.org/10.1016/j.prro.2020.05.011DOI Listing

Application of the Sea Urchin Embryo Test in Toxicity Evaluation and Effect-Directed Analysis of Wastewater Treatment Plant Effluents.

Environ Sci Technol 2020 Jul 28;54(14):8890-8899. Epub 2020 Jun 28.

Department of Analytical Chemistry, Faculty of Science and Technology, 48080 Bilbao, Basque Country, Spain.

Sea urchin embryo assay was used to assess general toxicity at four wastewater treatment plant effluents of Biscay (Gorliz, Mungia, Gernika, and Galindo), and within the tested range, all the extracts showed embryo growth inhibition and skeleton malformation activities with EC values, in relative enrichment factor units, between 1.1-16.8 and 1. Read More

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http://dx.doi.org/10.1021/acs.est.0c01504DOI Listing

Pharmacogenetics CYP2D6 Study Focused on the Pharmacovigilance of Herbal Antidepressants.

Front Pharmacol 2020 13;11:683. Epub 2020 May 13.

Computational Pharmacy Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

The annual increase in depression worldwide together with an upward trend in the use of alternative medicine as treatment asks for developing reliable safety profiles of herbal based medicine. A considerable risk on adverse reactions exists when herbal remedies are combined with prescription medication. Around 25% of the drugs, including many antidepressants, depend on the activity of CYP2D6 for their metabolism and corresponding efficacy. Read More

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http://dx.doi.org/10.3389/fphar.2020.00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237870PMC

Perinatal exposure to bisphenol A causes a disturbance of neurotransmitter metabolic pathways in female mouse offspring: A focus on the tryptophan and dopamine pathways.

Chemosphere 2020 Sep 9;254:126715. Epub 2020 Apr 9.

Department of Hygienic Analysis and Detection, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, No. 101 Longmian Avenue, Nanjing, 211166, China. Electronic address:

Perinatal exposure to bisphenol A (BPA) contributes to neurological disorders in offspring, but the underlying mechanisms are still poorly understood. The abnormal release of neuroactive metabolites in the tryptophan (TRP) and dopamine (DA) pathways is considered to be closely associated with some disorders. Thus, in this study, TRP and DA pathways in adult female mouse offspring were investigated when the pregnant mice were given either vehicle or BPA (2, 10, or 100 μg/kg/d) from day 6 of gestation until weaning. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126715DOI Listing
September 2020
3.340 Impact Factor

[Lithium ascorbate as a cerebroprotective agent in a model of ischemic stroke].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3. Vyp. 2):29-32

National Research Tomsk Polytechnic University, Research School of Chemical and Biomedical Technologies, Tomsk, Russia.

Introduction: Ischemic stroke is one of the most severe neurological pathologies with high mortality and disability. In this connection, the development and study of new drugs for the prevention and treatment of stroke is an extremely important task. A new approach to neuroprotection is the use of lithium salts with antioxidant activity. Read More

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http://dx.doi.org/10.17116/jnevro202012003229DOI Listing

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation.

Life Sci 2020 Jul 13;252:117669. Epub 2020 Apr 13.

Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. Electronic address:

Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effects of Rg1 in CSDS mice and explore its molecular mechanism. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117669DOI Listing
July 2020
2.702 Impact Factor

Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects.

Arch Toxicol 2020 05 4;94(5):1417-1441. Epub 2020 Apr 4.

Toxicology Department, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Depressive disorders are amongst the greatest mental health challenges, with an increasing number of patients being diagnosed each year. Though it has not yet been fully elucidated, redox metabolism imbalances and oxidative stress seem to play a major role in the pathogenesis of depressive disorders. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressants, considered to have a better tolerability. Read More

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http://dx.doi.org/10.1007/s00204-020-02721-6DOI Listing

Influence of Selected Antidepressants on the Ciliated Protozoan : Toxicity, Bioaccumulation, and Biotransformation Products.

Molecules 2020 Mar 25;25(7). Epub 2020 Mar 25.

Department of Environmental Health Sciences, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warszawa, Poland.

The present study aimed to evaluate the effect of the most common antidepressants on aquatic protozoa. was used as the model protozoan. The biological activity of four antidepressants, namely fluoxetine, sertraline, paroxetine, and mianserin, toward was evaluated. Read More

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http://dx.doi.org/10.3390/molecules25071476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180767PMC

Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium.

Ann Agric Environ Med 2020 Mar 12;27(1):129-133. Epub 2019 Apr 12.

Chair and Department of Medical Chemistry, Medical University, Lublin, Poland.

Introduction: Lithium has been used in medicine for almost seventy years. Besides beneficial effects, its therapy may cause serious side-effects, with kidney and liver being the organs most vulnerable to its harmful influence. Therefore, research on protective agents against lithium toxicity has been continuing for some time. Read More

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http://dx.doi.org/10.26444/aaem/105926DOI Listing

A novel insight into the potential toxicity mechanisms of Zhi-Zi-Hou-Po decoction by dynamic urinary metabolomics based on UHPLC-Q-Exactive Orbitrap-MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Apr 3;1142:122019. Epub 2020 Feb 3.

Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

In recent years, depression occurs frequently. Given the long duration of the disease and the high risk of recurrence, the treatment of depression requires long-term medication. Zhi-Zi-Hou-Po Decoction (ZZHPD) has been used in clinical treatment of depression and related diseases for many years, and the potential toxic damage caused by its long-term use has gradually emerged. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122019DOI Listing

Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model.

Toxicol Lett 2020 Jun 21;325:43-50. Epub 2020 Feb 21.

Metabolic Profiling and Clinical Pathology, Investigational Toxicology, Pharmaceuticals Division, Bayer AG, Berlin, Germany. Electronic address:

As a consequence of the detoxification process, drugs and drug related metabolites can accumulate in the liver, resulting in drug induced liver injury (DILI), which is the major cause for dose limitation. Amitriptyline, a commonly used tricyclic anti-depressant, is known to cause DILI. The mechanism of Amitriptyline induced liver injury is not yet completely understood. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.02.007DOI Listing

The teratogenic effects of sertraline in mice.

Birth Defects Res 2020 Aug 19;112(13):1014-1024. Epub 2020 Feb 19.

Department of Pediatrics, Dell Pediatric Research Institute, Dell Medical School, University of Texas at Austin, Austin, Texas.

Background: Selective serotonin reuptake inhibitors (SSRIs), which include paroxetine (Paxil), sertraline (Zoloft), fluoxetine (Prozac), citalopram (Celexa), and escitalopram (Lexapro), are the most common antidepressants prescribed to pregnant women. There is considerable debate in the literature regarding the developmental toxicities of SSRIs individually, and as a class.

Methods: It is considered unethical to perform developmental toxicity studies on pregnant women, but rodent and nonrodent species provide laboratory-controlled experimental models to examine the toxicity of SSRI exposure during pregnancy. Read More

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http://dx.doi.org/10.1002/bdr2.1660DOI Listing

Biochemical and Behavioral Characterization of IN14, a New Inhibitor of HDACs with Antidepressant-Like Properties.

Biomolecules 2020 Feb 14;10(2). Epub 2020 Feb 14.

Laboratorio de Neurobiología Conductual, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.

Evidence suggests that histone deacetylases (HDACs) inhibitors could be used as an effective treatment for some psychiatric and neurological conditions such as depression, anxiety and age-related cognitive decline. However, non-specific HDAC inhibiting compounds have a clear disadvantage regarding their efficacy and safety, thus the need to develop more selective ones. The present study evaluated the toxicity, the capacity to inhibit HDAC activity and antidepressant-like activity of three recently described class I HDAC inhibitors IN01, IN04 and IN14, using toxicity test, fluorometric HDAC activity assay and forced-swimming test, respectively. Read More

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http://dx.doi.org/10.3390/biom10020299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072255PMC
February 2020

AMPA receptor-mTORC1 signaling activation is required for neuroplastic effects of LY341495 in rat hippocampal neurons.

Sci Rep 2020 01 22;10(1):993. Epub 2020 Jan 22.

Paik Institute for Clinical Research, Inje University, Busan, 47392, Republic of Korea.

The group II metabotropic glutamate 2/3 (mGlu) receptor antagonist LY341495 produces antidepressant-like effects by acting on mammalian target of rapamycin complex 1 (mTORC1) signaling and α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors in rodent. We investigated whether LY341495 affects neuroplasticity via these mechanisms in rat primary hippocampal cultures under conditions of dexamethasone (DEX)-induced neurotoxicity. Ketamine was used for comparison. Read More

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http://dx.doi.org/10.1038/s41598-020-58017-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976560PMC
January 2020
5.078 Impact Factor

Drug-Induced Liver Injury (DILI) in Patients with Depression Treated with Antidepressants: A Retrospective Multicenter Study.

Pharmacopsychiatry 2020 Mar 20;53(2):60-64. Epub 2020 Jan 20.

Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, LWL-Klinik Dortmund, Dortmund, Germany.

Introduction: Drug-induced liver injury (DILI) is the 4th most common cause of liver damage in Western countries and can be caused by antidepressants.

Methods: Against the background of increasing antidepressant prescriptions and increasing use of polypharmacy, we analyzed administered antidepressants and other pharmacological substances, liver toxicity, comorbid somatic secondary diseases together with the occurrence of DILI in a patient population of 6 centers throughout Germany.

Results: The majority of the enrolled 329 patients received polypharmacological treatment in an inpatient setting. Read More

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http://dx.doi.org/10.1055/a-1071-8028DOI Listing

Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish.

Sci Total Environ 2020 Apr 7;712:136564. Epub 2020 Jan 7.

MARE - Marine and Environmental Sciences Centre, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal; Departamento de Biologia Animal, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Pharmaceutical compounds are continuously released into the aquatic environment, resulting in their ubiquitous presence in many estuarine and coastal systems. As pharmaceuticals are designed to produce effects at very low concentrations and target specific evolutionary conserved pathways, there are growing concerns over their potential deleterious effects to the environment and specifically to aquatic organisms, namely in early life-stages. In this context, the long-term effects of exposure of juvenile meagre Argyrosomus regius to three different pharmaceuticals were investigated. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.136564DOI Listing

Comparison of the Efficacy and Safety of Pregabalin and Duloxetine in Taxane-Induced Sensory Neuropathy: A Randomized Controlled Trial.

Clin Drug Investig 2020 Mar;40(3):249-257

Department of Clinical Pharmacy, Faculty of Pharmacy, Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.

Background And Objective: Taxane-induced peripheral neuropathy (TIPN) is a main toxicity of taxanes with no effective treatment. This study aimed to compare the efficacy and safety of pregabalin (150 mg daily) and duloxetine (60 mg daily) for managing TIPN in breast cancer patients.

Methods: This randomized, double-blind, Phase II clinical trial was carried out at a chemotherapy center affiliated to Mazandaran University of Medical Sciences. Read More

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http://dx.doi.org/10.1007/s40261-019-00882-6DOI Listing
March 2020
1.704 Impact Factor

Pediatric Toxidrome Simulation Curriculum: Bupropion Overdose.

MedEdPORTAL 2019 10 25;15:10846. Epub 2019 Oct 25.

Associate Professor, Department of Pediatrics, Division of Emergency Medicine, University of Washington School of Medicine.

Introduction: Bupropion is a commonly used antidepressant, and overdose can lead to both neurologic and cardiovascular toxicity, including agitation, seizure, tachycardia, QT and QRS prolongation, and rhythm disturbances.

Methods: We developed this simulation case for attendings, fellows, nurse practitioners, and nurses in the pediatric emergency department (ED). The scenario involved a 13-year-old male presenting to the ED with altered mental status and a generalized tonic-clonic seizure shortly after arrival. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946581PMC
October 2019

Immunohistological Biomarkers of Toxicity by a Pharmaceutical Antidepressant in the Freshwater Cichlid Fish Cichlasoma dimerus (Teleostei, Cichliformes).

Bull Environ Contam Toxicol 2020 Feb 1;104(2):180-184. Epub 2020 Jan 1.

Laboratorio de Ecotoxicología Acuática, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.

Melano-macrophage centers (MMCs) are nodular clusters of pigmented macrophages, implicated in homeostasis and destruction and recycling of endogenous and exogenous material. They can increase in size and/or frequency under environmental stress resulting in immunohistological biomarkers of water quality. Fluoxetine (FLX), a commonly prescribed antidepressant, can cause neuroendocrine, behavioral and reproductive alterations in teleost fish. Read More

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http://dx.doi.org/10.1007/s00128-019-02770-3DOI Listing
February 2020

The effects of pretreatment with lithium metaborate dihydrate on lipid peroxidation and Ca, Fe, Mg, and K levels in serum of Wistar albino male rats exposed to Cd.

Environ Sci Pollut Res Int 2020 Mar 30;27(7):7702-7711. Epub 2019 Dec 30.

Department of Statistics, Bitlis Eren University, Faculty of Science, Bitlis, Turkey.

Boron and boron compounds have beneficial biological effects. Lithium metaborate dihydrate (LMBDH) is used in many branches of industry. Despite its wide industrial use, there is limited information about its biological effects on antioxidant defense system and trace element homeostasis. Read More

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http://dx.doi.org/10.1007/s11356-019-07516-6DOI Listing

Magnetic solid-phase extraction coupled with UHPLC-MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples.

Bioanalysis 2020 Jan;12(1):35-52

Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, PR China.

Routine therapeutic drug monitoring is highly recommended since common antidepressant combinations increase the risk of drug-drug interactions or overlapping toxicity. A magnetic solid-phase extraction by using C-functionalized magnetic silica nanoparticles (C-FeO@SiO NPs) as sorbent was proposed for rapid extraction of venlafaxine, paroxetine, fluoxetine, norfluoxetine and sertraline from clinical plasma and urine samples followed by ultra-HPLC-MS/MS assay.  The synthesized C-FeO@SiO NPs showed high magnetization and efficient extraction for the analytes. Read More

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http://dx.doi.org/10.4155/bio-2019-0171DOI Listing
January 2020

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.

Int J Mol Sci 2019 Dec 11;20(24). Epub 2019 Dec 11.

Department of Molecular Biology, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany.

Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Read More

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http://dx.doi.org/10.3390/ijms20246253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941101PMC
December 2019

Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice.

Psychopharmacology (Berl) 2020 Feb 11;237(2):363-374. Epub 2019 Dec 11.

Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, 97105-900, Brazil.

Rationale: The association between depression and diabetes has been recognized for many years, but the nature of this relationship remains uncertain.

Objectives: This study investigated the antidepressant-like effect of (p-ClPhSe) on mice made diabetic by streptozotocin (STZ) and the contribution of cerebral cortical Keap1/Nrf2/HO-1 signaling pathway for this effect.

Methods: Male adult Swiss mice received streptozotocin (STZ, 200 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00213-019-05372-3DOI Listing
February 2020

Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.

J Med Chem 2020 01 20;63(1):349-368. Epub 2019 Dec 20.

Instituto de Química Médica (IQM-CSIC) , 28006 Madrid , Spain.

Currently, there are only three FDA-approved drugs that inhibit human immunodeficiency virus (HIV) entry-fusion into host cells. The situation is even worse for enterovirus EV71 infection for which no antiviral therapies are available. We describe here the discovery of potent entry dual inhibitors of HIV and EV71. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b01737DOI Listing
January 2020
9 Reads

The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss).

Sci Total Environ 2020 Mar 22;708:135082. Epub 2019 Nov 22.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy. Electronic address:

The worldwide consumption of antidepressants is raising as well as their concentrations in the aquatic environment. This increases the risk of food chain contamination and bioaccumulation in aquatic biota. The aim of this study was to describe a potential risk of sertraline as a pollutant from water environment, wherein rainbow trout (Oncorhynchus mykiss) has been chosen as the test organism, because predatory fish are on the top of the food chain in the aquatic environment. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.135082DOI Listing
March 2020
5 Reads

Recurrence of Serotonin Toxicity and Influence of Cytochrome 2D6 Polymorphism.

Prim Care Companion CNS Disord 2019 Nov 27;21(6). Epub 2019 Nov 27.

Department of Intensive Care, Cliniques Universitaires St-Luc, Ave Hippocrate, 10, 1200 Brussels, Belgium.

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http://dx.doi.org/10.4088/PCC.19l02426DOI Listing
November 2019

Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs.

J Clin Psychiatry 2019 11 26;80(6). Epub 2019 Nov 26.

Department of Health Sciences, University of Florence, Florence, Italy.

Withdrawal symptoms commonly occur during tapering and/or after discontinuation of antidepressant drugs, particularly selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. Withdrawal symptomatology does not necessarily subside within a few weeks and may be associated with other manifestations of behavioral toxicity (loss of treatment efficacy, refractoriness, switch into mania/hypomania, or paradoxical reactions). The oppositional model of tolerance provides a pathophysiologic basis for understanding and managing withdrawal syndromes. Read More

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http://dx.doi.org/10.4088/JCP.19com12794DOI Listing
November 2019

[Symptoms of lithium toxicity at therapeutic levels].

Ned Tijdschr Geneeskd 2019 11 14;163. Epub 2019 Nov 14.

Elisabeth-TweeSteden Ziekenhuis, Afd. Psychiatrie, Tilburg.

A 60-year-old woman was admitted to the medical psychiatric unit with neurological and psychiatric symptoms. She was being treated with a maintenance dose of lithium for bipolar I disorder. Lithium toxicity and manic state were both considered. Read More

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November 2019

Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination.

Environ Sci Pollut Res Int 2020 Jan 25;27(2):1941-1955. Epub 2019 Nov 25.

Research Unit of Analysis and Process Applied to the Environment-APAE UR17ES32, Higher Institute of Applied Sciences and Technology Mahdia "ISSAT", University of Monastir, 5100, Mahdia, Tunisia.

In the present study, the occurrence of 40 pharmaceuticals belonging to several therapeutic groups was investigated for the first time in hospital effluent, wastewater treatment plant influent and effluent, and seawater in Mahdia, Tunisia. Forty-six samples were collected within a 6-month sampling period. Pharmaceuticals were analyzed using solid-phase extraction followed by ultra-performance liquid chromatography-triple quadrupole mass spectrometry. Read More

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http://dx.doi.org/10.1007/s11356-019-06866-5DOI Listing
January 2020
2.828 Impact Factor

Drug-Induced Liver Injury in the Setting of Analgesic Use.

Clin Liver Dis 2020 Feb 1;24(1):121-129. Epub 2019 Nov 1.

Baylor College of Medicine, 6620 Main Street, Suite 1425, Houston, TX 77030, USA. Electronic address:

No professional society has created guidelines to aid clinicians in the management of analgesics in the setting of hepatic injury. Acetaminophen overdose is the most common cause of acute liver failure in the United States. In the setting of acetaminophen toxicity, N-acetylcysteine remains the standard of care. Read More

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http://dx.doi.org/10.1016/j.cld.2019.09.008DOI Listing
February 2020

Fatal Toxicity Indices for Medicine-Related Deaths in New Zealand, 2008-2013.

Drug Saf 2020 03;43(3):223-232

Best Practice Advocacy Centre New Zealand, Level 8, 10 George Street, Dunedin, 9016, New Zealand.

Introduction: The fatal toxicity index (FTI) is a measure for assessing the relative risks of death due to the medicines prescribed in a population. This knowledge is useful for prescribers and informs medicine safety initiatives. This study aimed to calculate FTIs for the New Zealand population using three methodologies. Read More

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http://dx.doi.org/10.1007/s40264-019-00885-4DOI Listing

Formulation of polymeric nanoparticles of antidepressant drug for intranasal delivery.

Ther Deliv 2019 11 20;10(11):683-696. Epub 2019 Nov 20.

Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India.

The manuscript describes the performance of nanoparticles loaded with antidepressant drug for nose-to-brain drug delivery. Poly-lactic-co-glycolic acid-loaded nanoparticles of agomelatine were prepared by nanoprecipitation method using poloxamer 407 as stabilizer. The process parameters were optimized using factorial design. Read More

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http://dx.doi.org/10.4155/tde-2019-0060DOI Listing
November 2019

Two antidepressants fluoxetine and sertraline cause growth retardation and oxidative stress in the marine rotifer Brachionus koreanus.

Aquat Toxicol 2020 Jan 1;218:105337. Epub 2019 Nov 1.

Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

To understand effects of two widely used antidepressant on the antioxidant defense mechanism in the marine rotifer Brachionus koreanus, we assessed acute toxicity and measured population growth, reactive oxygen species (ROS) levels, glutathione (GSH) levels, and antioxidant enzymatic activities (GST, GR, and SOD) in response to fluoxetine hydrochloride (FLX) and sertraline hydrochloride (SER). The no observed effect concentration-24 h of fluoxetine and sertraline were 1000 μg/L and 450 μg/L, respectively, whereas the median lethal concentration (LC50)-24 h of fluoxetine and sertraline were 1560 μg/L and 507 μg/L, respectively. Both fluoxetine and sertraline caused significant reduction (P < 0. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.105337DOI Listing
January 2020
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Acute exposure of zebrafish (Danio rerio) larvae to environmental concentrations of selected antidepressants: Bioaccumulation, physiological and histological changes.

Comp Biochem Physiol C Toxicol Pharmacol 2020 Mar 13;229:108670. Epub 2019 Nov 13.

Department of Environmental Health Sciences, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, Warsaw PL-02097, Poland.

Antidepressants have been detected in surface waters worldwide at ng-μg/L concentration. These compounds can exert adverse effects on fish even at low levels. But, all previous analyses have concentrated on adult fish. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.108670DOI Listing

Identification of the main active antidepressant constituents in a traditional Turkish medicinal plant, Centaurea kurdica Reichardt.

J Ethnopharmacol 2020 Mar 2;249:112373. Epub 2019 Nov 2.

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey. Electronic address:

Ethnopharmacological Relevance: In Turkish folk medicine, infusions and decoctions prepared from the flowers, fruits and aerial parts of Centaurea kurdica Reichardt (Asteraceae) are used as sedative and antidepressant-like effects of various sedative plants have been identified in many studies. The present study was designed to evaluate the antidepressant activity of this plant.

Materials And Methods: n-Hexane, ethyl acetate (EtOAc), and methanol (MeOH) extracts were prepared from the branches with leaves and also flowers of the plant. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112373DOI Listing

Serotonin Toxicity: Associated Agents and Clinical Characteristics.

J Clin Psychopharmacol 2019 Nov/Dec;39(6):628-633

Oregon Poison Center.

Background: Serotonin toxicity is a common cause of drug-induced altered mental status. However, data on the causes of serotonin toxicity, symptomatology, complications, and rate of antidotal treatment are limited.

Methods: This study evaluated cases of serotonin toxicity in the ToxIC registry, an international database of prospectively collected cases seen by medical toxicologists. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001121DOI Listing

Determination and photodegradation of sertraline residues in aqueous environment.

Environ Pollut 2020 Jan 23;256:113431. Epub 2019 Oct 23.

Jozef Stefan Institute, Department of Environmental Sciences, Jamova 39, Ljubljana, Slovenia; Jozef Stefan International Postgraduate School, Jamova 39, Ljubljana, Slovenia. Electronic address:

Sertraline is an antidepressant drug that has been frequently reported in the aquatic environment and biota. While the research has mostly dealt with its occurrence and toxicity, there is a lack of information pertaining to its environmental transformation. The present study aimed to fill in these gaps by giving an insight into mechanisms of sertraline phototransformation in surface waters, which was recognized as the main transformation pathway for this contaminant. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113431DOI Listing
January 2020

Exposure paradigm of fluoxetine impacted the Faxonius virilis agonistic behavior differently.

Sci Total Environ 2020 Jan 4;699:134300. Epub 2019 Sep 4.

Laboratory for Sensory Ecology, Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA; University of Michigan Biological Station, Pellston, MI 49769, USA.

Pharmaceutically active compounds are major contaminants of aquatic environments. The effects on aquatic organisms have been assessed mostly through eco-toxicological tests performed using static exposure systems or flow through systems with constant concentrations. Yet, constant concentration exposures ignore the spatio-temporal dynamics of chemicals in flowing environments. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.134300DOI Listing
January 2020

Environmental concentration of fluoxetine disturbs larvae behavior and increases the defense response at molecular level in zebrafish (Danio rerio).

Environ Sci Pollut Res Int 2019 Dec 28;26(34):34943-34952. Epub 2019 Oct 28.

Department of Biosciences, University of Milan, via Celoria 26, 20133, Milan, Italy.

Fluoxetine (FLX) is one of the main antidepressants used worldwide. After human use, FLX enters the aquatic ecosystems, where it has commonly detected in the high ng/L concentration range. Several investigations have shown that exposure to different concentrations of FLX caused different adverse effects towards a number of aquatic species. Read More

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http://dx.doi.org/10.1007/s11356-019-06619-4DOI Listing
December 2019

1-Methyl-1,2,3,4-tetrahydroisoquinoline - The toxicological research on an exo/endogenous amine with antidepressant-like activity - In vivo, in vitro and in silico studies.

Pharmacol Rep 2019 Dec 9;71(6):1140-1146. Epub 2019 Jul 9.

Department of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.

Background: 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) demonstrates significant neuroprotective activity. It can interact with agonistic conformation of dopamine (DA) receptors. 1MeTIQ inhibits the formation of 3,4-dihydroxyphenylacetic acid as well as production of free radicals and shifts DA catabolism toward COMT-dependent O-methylation. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.06.016DOI Listing
December 2019

The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review.

Br J Anaesth 2020 01 22;124(1):44-62. Epub 2019 Oct 22.

Department of Anaesthesia, Royal North Shore Hospital of Sydney, Sydney, NSW, Australia; Northern Clinical School, University of Sydney, Sydney, NSW, Australia.

Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter system. Common serotonergic drugs include many antidepressants, antipsychotics, and opioid analgesics, particularly fentanyl, tramadol, meperidine (pethidine), and methadone, but rarely morphine and other related phenanthrenes. Symptoms of serotonin toxicity are attributable to an effect on monoaminergic transmission caused by an increased synaptic concentration of serotonin. Read More

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http://dx.doi.org/10.1016/j.bja.2019.08.010DOI Listing
January 2020
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