5,168 results match your criteria Toxicity Antidepressants


Amorphous aggregation of tau in the presence of titanium dioxide nanoparticles: biophysical, computational, and cellular studies.

Int J Nanomedicine 2019 31;14:901-911. Epub 2019 Jan 31.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,

Background: Nanoparticles (NPs) when injected into the body can reach target tissues like nervous system and interact with tau proteins and neurons. This can trigger conformational changes of tau and may affect NP toxicity.

Methods: In this study, we used several biophysical techniques (extrinsic and intrinsic fluorescence spectroscopy, circular dichroism (CD) spectroscopy, ultraviolet (UV)-visible spectroscopy), transmission electron microscopy (TEM) investigations, molecular docking and molecular dynamics studies, and cellular assays [3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) and flow cytometry) to reveal how structural changes of tau protein can change the cytotoxicity of titanium dioxide (TiO) NPs against neuron-like cells (SH-SY5Y) cells. Read More

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http://dx.doi.org/10.2147/IJN.S194658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362919PMC
March 2019
1 Read

Resistance of Rapistrum rugosum to tribenuron and imazamox due to Trp574 or Pro197 substitution in the acetolactate synthase.

Pestic Biochem Physiol 2019 Feb 4;154:1-6. Epub 2018 Dec 4.

Aristotle University of Thessaloniki, School of Agriculture, Thessaloniki, Greece. Electronic address:

Ten putative resistant and two susceptible Rapistrum rugosum populations originating from Greece were studied for resistance to acetolactate synthase (ALS)-inhibiting herbicides, using dose-response assays, sequencing of als gene and in vitro ALS activity assays. The dose-response assays showed that one (P1) out of ten putative resistant populations was cross-resistant to tribenuron and imazamox, while another population (P4) was resistant to tribenuron only. All populations were susceptible to MCPA at the recommended rate. Read More

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http://dx.doi.org/10.1016/j.pestbp.2018.12.001DOI Listing
February 2019

Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo.

Chem Commun (Camb) 2019 Feb;55(17):2477-2480

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo. Moreover, we have successfully used the high specificity of one of the probes to visualize MAO-A activity in zebrafish and tumor tissue for the first time. Read More

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http://dx.doi.org/10.1039/c8cc10084eDOI Listing
February 2019
3 Reads
6.834 Impact Factor

Exposure to dilute concentrations of bupropion affects zebrafish early life stages.

Chemosphere 2019 May 25;222:175-183. Epub 2019 Jan 25.

Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, UnB, 70910-900, Brasília, Distrito Federal, Brazil. Electronic address:

Psychiatric pharmaceuticals are one of the most prescribed active substances globally. Bupropion (BPP) is an antidepressant that acts via inhibition of norepinephrine and dopamine reuptake. It has been found in various water matrices, and thus its effects on aquatic organisms must be studied. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.141DOI Listing
May 2019
3 Reads

Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.

Pharmacology 2019 29;103(3-4):189-201. Epub 2019 Jan 29.

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi,

Background: A report examining whether clinically available antidepressants increase urethral smooth muscle contraction via antagonistic effects on the α2-adrenoceptor (α2-AR) is lacking.

Objectives: The present study was performed to evaluate the potential of clinically available antidepressants to reverse α2-AR-mediated contractile inhibition in rat vas deferens, in order to predict whether they can induce voiding impairment.

Method: The effects of 18 antidepressants of different classes on electrical field stimulation (EFS)-induced contractions suppressed by 10-8 mol/L clonidine (a selective α2-AR agonist) in isolated rat vas deferens were investigated and related to their respective clinical blood concentrations. Read More

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http://dx.doi.org/10.1159/000495616DOI Listing

Twelve Chinese herbal preparations for the treatment of depression or depressive symptoms in cancer patients: a systematic review and meta-analysis of randomized controlled trials.

BMC Complement Altern Med 2019 Jan 23;19(1):28. Epub 2019 Jan 23.

School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.

Background: Patients with cancer are vulnerable to depression or other depressive conditions. The aim of this paper was to evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of depression or depressive symptoms in cancer patients.

Methods: CENTRAL, MEDLINE, EMBASE, PsycINFO, CNKI, VIP, SinoMed, and online clinical trial registry websites were searched for relevant RCTs until May 2017. Read More

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http://dx.doi.org/10.1186/s12906-019-2441-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345004PMC
January 2019
2 Reads

First aid interventions by laypeople for acute oral poisoning.

Cochrane Database Syst Rev 2018 12 19;12:CD013230. Epub 2018 Dec 19.

Centre for Evidence-Based Practice (CEBaP), Belgian Red Cross, Motstraat 42, Mechelen, Belgium, 2800.

Background: Oral poisoning is a major cause of mortality and disability worldwide, with estimates of over 100,000 deaths due to unintentional poisoning each year and an overrepresentation of children below five years of age. Any effective intervention that laypeople can apply to limit or delay uptake or to evacuate, dilute or neutralize the poison before professional help arrives may limit toxicity and save lives.

Objectives: To assess the effects of pre-hospital interventions (alone or in combination) for treating acute oral poisoning, available to and feasible for laypeople before the arrival of professional help. Read More

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http://doi.wiley.com/10.1002/14651858.CD013230
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http://dx.doi.org/10.1002/14651858.CD013230DOI Listing
December 2018
8 Reads

Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development.

PLoS Comput Biol 2018 12 10;14(12):e1006672. Epub 2018 Dec 10.

Laboratory of Neurogenetics, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint-Petersburg, Russia.

Kynurenines, the products of tryptophan oxidative degradation, are involved in multiple neuropathologies, such as Huntington's chorea, Parkinson's disease, senile dementia, etc. The major cause for hydroxykynurenines's neurotoxicity is the oxidative stress induced by the reactive oxygen species (ROS), the by-products of L-3-hydroxykynurenine (L-3HOK) and 3-hydroxyanthranilic acid (3HAA) oxidative self-dimerization. 2-aminophenol (2AP), a structural precursor of L-3HOK and 3HAA, undergoes the oxidative conjugation to form 2-aminophenoxazinone. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301705PMC
December 2018
4 Reads

A mechanistic approach to the in-vitro resistance modulating effects of fluoxetine against meticillin resistant Staphylococcus aureus strains.

Microb Pathog 2019 Feb 7;127:335-340. Epub 2018 Dec 7.

School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil. Electronic address:

Emergence of methicilin resistant Staphylococcus aureus (MRSA) strains is a major cause of infirmity worldwide and has limited our therapeutic options against these pathogens. In this regard, the search for candidates with an antimicrobial activity, with a greater efficacy and a lower toxicity, is necessary. As a result, there is greater need to search for resistance modifying agents which, in combination with existing drugs, will restore the efficacy of these drugs. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.11.056DOI Listing
February 2019
1 Read

Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.

J Neuroinflammation 2018 Dec 8;15(1):338. Epub 2018 Dec 8.

Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, 250012, Shandong Province, People's Republic of China.

Background: Neuroinflammation has recently emerged as a critical risk factor in the pathophysiology of depression. However, the underlying molecular mechanisms and the development of novel therapeutic strategies as means to target these inflammatory pathways for use in the treatment of depression remain unresolved. In the present study, we aimed to investigate the molecular events of neuroinflammation as related to its induction of depression-like behaviors. Read More

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http://dx.doi.org/10.1186/s12974-018-1377-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286788PMC
December 2018
1 Read

Comparison of Prioritisation Schemes for Human Pharmaceuticals in the Aquatic Environment.

Environ Sci Pollut Res Int 2019 Feb 4;26(4):3479-3491. Epub 2018 Dec 4.

School of Geography, University of Leeds, Woodhouse Lane, Leeds, West Yorkshire, LS2 9JT, UK.

Only a small proportion of pharmaceuticals available for commercial use have been monitored in the aquatic environment, and even less is known about the effects on organisms. With thousands of pharmaceuticals in use, it is not feasible to monitor or assess the effects of all of these compounds. Prioritisation schemes allow the ranking of pharmaceuticals based on their potential as environmental contaminants, allowing resources to be appropriately used on those which are most likely to enter the environment and cause greatest harm. Read More

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http://link.springer.com/10.1007/s11356-018-3834-9
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http://dx.doi.org/10.1007/s11356-018-3834-9DOI Listing
February 2019
9 Reads

Transformation products of citalopram: Identification, wastewater analysis and in silico toxicological assessment.

Chemosphere 2019 Feb 5;217:858-868. Epub 2018 Nov 5.

Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisboa, Portugal.

The objective of this study was to identify transformation products (TPs) of citalopram (CIT), an antidepressant drug, in laboratory experiments. Moreover, toxicity predictions and analyzes in wastewater samples were performed. For the formation of TPs, raw water was used for the processes of hydrolysis; photodegradation under ultraviolet (UV) irradiation and chlorination. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.11.027DOI Listing
February 2019
9 Reads

Aquatic ecotoxicity of an antidepressant, sertraline hydrochloride, on microbial communities.

Sci Total Environ 2019 Mar 12;654:129-134. Epub 2018 Nov 12.

Xinjiang Key Laboratory of Environmental Pollution and Bioremediation, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China; College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

Sertraline hydrochloride (Ser-HCl), a widely used antidepressant, becomes an aquatic contaminant via metabolic excretion and improper disposal; however, it is unknown how Ser-HCl affects aquatic microbial communities. The present study investigated the effects of Ser on the structures of aquatic microbial communities via high-throughput sequencing analyses. Ser-HCl treatment inhibited the growth of two model algae (the green alga, Chlorella vulgaris, and the cyanobacterium, Microcystis aeruginosa) and decreased the chlorophyll a (Chl-a) concentration in the microcosm to reduce the photosynthetic efficiency. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.164DOI Listing
March 2019
1 Read
4.099 Impact Factor

Pharmacogenetics of Membrane Transporters of Tacrolimus in Solid Organ Transplantation.

Clin Pharmacokinet 2018 Nov 10. Epub 2018 Nov 10.

Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Rennes University Hospital, Rennes, France.

Membrane transporters play an essential role in the pharmacokinetics of drugs as they mediate exchanges between biological compartments. Tacrolimus is characterized by wide interpatient variability in terms of its pharmacokinetics that may in part be due to genetic factors. The pharmacogenetics of drug transporters is therefore a promising area to explore in the clinical pharmacology of tacrolimus. Read More

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http://dx.doi.org/10.1007/s40262-018-0717-7DOI Listing
November 2018
23 Reads

[Combined effects of fluoxetine and triclosan on Pseudorasbora parva.]

Ying Yong Sheng Tai Xue Bao 2018 Sep;29(9):3058-3066

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.

We examined the effects of binary mixture of two different pharmaceutical and personal care products (PPCPs) on aquatic organisms. The topmouth gudgeon Pseudorasbora parva, native to northeast China, was used to study the combined effects of fluoxetine (FLX) and triclosan (TCS) on its different organs. After acute (4 h) and chronic (42 d) treatments, the combined effects of FLX/TCS on phase I and phase II detoxification enzymes, nervous system, digestive system and antioxidant system were evaluated. Read More

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http://www.cnki.net/kcms/doi/10.13287/j.1001-9332.201809.038
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http://dx.doi.org/10.13287/j.1001-9332.201809.038DOI Listing
September 2018
17 Reads

Accumulation, metabolite and active defence system responses of fluoxetine in zebrafish embryos: Influence of multiwalled carbon nanotubes with different functional groups.

Aquat Toxicol 2018 Dec 30;205:204-212. Epub 2018 Oct 30.

School of Hydraulic and Ecological Engineering, Nanchang Institute of Technology, Nanchang, 330099, China.

Studies on the bioavailability of organic contaminants adsorbed to nanomaterials are increasing. In this study, we investigated the interaction between fluoxetine (FLX) and three multiwalled carbon nanotubes (MWCNTs) with different functional groups in zebrafish (Danio rerio) embryos, focusing on the FLX accumulation, the formation of the metabolite norfluoxetine (NFLX), and the active defence system responses. The accumulation of FLX in zebrafish was intensified by MWCNTs (46-99%), which simultaneously facilitated the formation of the metabolite NFLX by 23-167%. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183085
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http://dx.doi.org/10.1016/j.aquatox.2018.10.018DOI Listing
December 2018
9 Reads

Tiansi Liquid Modulates Gut Microbiota Composition and Tryptophan⁻Kynurenine Metabolism in Rats with Hydrocortisone-Induced Depression.

Molecules 2018 Oct 31;23(11). Epub 2018 Oct 31.

School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Tiansi Liquid is a traditional Chinese herbal medicine used to treat depression; however, the underlying mechanisms remain unclear. Here, we examined the effect of Tiansi Liquid in a rat model of hydrocortisone-induced depression using behavioral testing, 16S rRNA high-throughput pyrosequencing and high-performance liquid chromatography-mass spectrometry-based metabolomics of the tryptophan (TRP)⁻kynurenine (KYN) pathway. Tiansi Liquid significantly improved the sucrose preference and exploratory behavior of the depressive rats. Read More

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http://www.mdpi.com/1420-3049/23/11/2832
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http://dx.doi.org/10.3390/molecules23112832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278342PMC
October 2018
5 Reads

Linezolid-associated serotonin toxicity after escitalopram discontinuation: concomitant drug considerations.

BMJ Case Rep 2018 Oct 30;2018. Epub 2018 Oct 30.

College of Pharmacy, University of Florida, Gainesville, Florida, USA.

We report a case of a hospitalised patient who developed probable serotonin toxicity shortly after the initiation of linezolid in whom the selective serotonin reuptake inhibitor (SSRI) escitalopram had been recently discontinued. On day 2 of linezolid administration, the patient reported severe anxiety and was observed to have full body jerking and twitching motions without mental status change. Notably, the patient was concomitantly receiving the antidepressant, trazodone and the benzodiazepine, clonazepam possibly affecting the severity and manifestations of serotonin toxicity. Read More

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http://dx.doi.org/10.1136/bcr-2018-226597DOI Listing
October 2018
4 Reads

Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague-Dawley rats.

Regul Toxicol Pharmacol 2018 Dec 23;100:45-51. Epub 2018 Oct 23.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) have developed as novel antidepressants and have been determined to possess higher efficacy and less adverse effects compared to other antidepressants. Our previous studies have showed that LPM570065, a new potent TRI, is relatively nontoxic in acute, subchronic toxicity and genotoxicity evaluations. In the current study, toxicity of LPM570065 was further evaluated on the fertility and early embryonic development in Sprague-Dawley rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02732300183027
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http://dx.doi.org/10.1016/j.yrtph.2018.10.008DOI Listing
December 2018
12 Reads

Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species.

Eur J Pharmacol 2018 Dec 16;841:113-121. Epub 2018 Oct 16.

Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan. Electronic address:

Sibutramine had been prescribed as an oral anorexiant that reduces dietary intake, but was withdrawn from the market due to frequent occurrence of severe cardiovascular events including hypertension. To elucidate the pathogenic mechanism of hypertension, we here investigated whether sibutramine facilitates damage and contraction of human aortic smooth muscle (HASM) cells or not. Treatment with sibutramine provoked HASM cell apoptosis, which was attributed to production of reactive oxygen species and mitochondria dysfunction. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.10.009DOI Listing
December 2018
2 Reads

The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats.

Pharmacol Rep 2018 Dec 21;70(6):1173-1179. Epub 2018 Jul 21.

Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil. Electronic address:

Background: The use of antidepressants in combination is common practice following non-response to single antidepressant agents. Nevertheless, the scientific literature lacks preclinical studies regarding the combined administration of antidepressants across multiple behavioral measures including, but not limited to, cognition. Hence, we aimed to determine the effects of paroxetine (PAR), venlafaxine (VEN) and bupropion (BUP) alone or combined (PAR+BUP or VEN+BUP) on spatial and affective memory tasks to advance the knowledge about the combined use of antidepressants in cognition. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.07.003DOI Listing
December 2018
4 Reads

Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?

Pharmacol Rep 2018 Dec 17;70(6):1168-1172. Epub 2018 May 17.

Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.

Background: Selenium is an essential element which shows protective properties against diverse harmful factors. Lithium compounds are widely used in medicine, but, in spite of undoubted beneficial effects, treatment with these compounds may lead to severe side effects, including renal, gastrointestinal, neurological, endocrine and metabolic disorders. This study was aimed at evaluating the influence of selenium and/or lithium on lithium, iron, zinc and copper content in rats' erythrocytes as well as estimate the action of additional selenium on lithium exposure effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17341140173079
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http://dx.doi.org/10.1016/j.pharep.2018.05.003DOI Listing
December 2018
2 Reads

Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics.

Sci Total Environ 2019 Feb 1;650(Pt 2):2731-2741. Epub 2018 Oct 1.

Department of Civil and Environmental Engineering, National University of Singapore, Singapore. Electronic address:

While it is well known that fluoxetine is more toxic to aquatic organisms at high pH, the metabolic dysregulations related to observed pH-dependent effects are still poorly understood. In the present study, we utilized a gas chromatography mass spectrometry (GC-MS) based metabolomics approach to assess metabolomic profile changes in developing zebrafish embryos following exposure (2 hpf-96 hpf) to different concentrations of fluoxetine at three environmentally relevant pH values (7.0, 8. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.364DOI Listing
February 2019
4 Reads

Role of food‑drug interactions in neurological and psychological diseases.

Acta Neurobiol Exp (Wars) 2018 ;78(3):187-197

Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara,Turkey.

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food‑drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food‑drug interaction in the treatment of neurological and psychological diseases. Read More

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January 2019
5 Reads

Impact of the widespread pharmaceutical pollutant fluoxetine on behaviour and sperm traits in a freshwater fish.

Sci Total Environ 2019 Feb 24;650(Pt 2):1771-1778. Epub 2018 Sep 24.

Monash University, School of Biological Sciences, Melbourne 3800, Australia.

Pharmaceutical pollutants are detected in aquatic habitats and wildlife tissues globally. One widespread contaminant of major concern is the antidepressant fluoxetine, which can affect behavioural and physiological processes in non-target species. Despite this, effects of fluoxetine on wildlife behaviour have seldom been investigated across multiple fitness-related contexts, especially at environmentally realistic concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.294DOI Listing
February 2019
4 Reads

Modulatory effect of quercetin and its glycosylated form on key enzymes and antioxidant status in rats penile tissue of paroxetine-induced erectile dysfunction.

Biomed Pharmacother 2018 Nov 4;107:1473-1479. Epub 2018 Sep 4.

Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, 340001, Nigeria.

This study sought to compare the effects of quercetin and rutin on some enzymes linked to erectile function as well as antioxidant status in penile tissue of paroxetine - induced erectile dysfunction in rats. Animals were randomly divided into twelve groups: normal control (NC), sildenafil (SD), quercetin (QA) (25 and 50 mg/kg), rutin (RU) (25 and 50 mg/kg), PAR (10 mg/kg); PAR + SD; PAR + QA, PAR + RU (25 and 50 mg/kg). After 14 days' treatment, phosphodiesterase-5' (PDE-5'), arginase, adenosine deaminase (ADA), acetylcholinesterase (AChE) and angiotensin-I converting enzyme (ACE) activities as well as malondialdehyde (MDA) and non-protein thiol levels were determined in rat penile tissues. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.08.128DOI Listing
November 2018
7 Reads

Nebenwirkungen der neuen Antidepressiva.

Fortschr Neurol Psychiatr 2018 09 24;86(9):592-603. Epub 2018 Sep 24.

One reason for the increasing use of new antidepressant drugs is due to a decreased toxicity compared to older agents. Nevertheless, there are still potentially dangerous side effects important to be considered. To improve treatment outcome it is therefore advantageous to obtain a detailed medical history, as well as to give specific information about the mechanisms of action of antidepressants before choosing the appropriate drug. Read More

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http://dx.doi.org/10.1055/a-0648-1760DOI Listing
September 2018
5 Reads

Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12220

Department of Rehabilitation Medicine, Daegu Fatima Hospital, Daegu, Republic of Korea.

Rationale: Venlafaxine is an antidepressant and anxiolytic agent that functions by inhibiting central serotonin and norepinephrine reuptake, and it is a relatively recently introduced drug. In particular, overdose of venlafaxine has been reported to cause severe cardiac toxicity including ventricular tachycardia, prolongation of QT interval, and seizure or severe muscular injury. However, reports describing venlafaxine-induced rhabdomyolysis with neuropathy remain scarce. Read More

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http://dx.doi.org/10.1097/MD.0000000000012220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155956PMC
September 2018
5 Reads

Exposure to low concentration of fluoxetine affects development, behaviour and acetylcholinesterase activity of zebrafish embryos.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 6;215:1-8. Epub 2018 Sep 6.

Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Asa Norte, 70910-900 Brasília, Distrito Federal, Brazil.

Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRI) antidepressant widely used in clinics and very often found in environmental samples of urban aquatic ecosystems in concentrations ranging from ng/L to μg/L. Fish populations might be especially susceptible to FLX due to the presence of conserved cellular receptors of serotonin. Neurotoxic effects on fish biota of polluted water bodies may be expected, but there are no sufficient studies in the current literature to elucidate this hypothesis. Read More

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http://dx.doi.org/10.1016/j.cbpc.2018.08.009DOI Listing
January 2019
21 Reads

Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors.

J Affect Disord 2019 01 24;242:52-59. Epub 2018 Aug 24.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Jiangsu, China. Electronic address:

Background: Numerous studies indicate that inflammation plays important roles in the development of depression. Astrocytes are crucial regulators of immune response in the central nervous system, and strongly activated by pro-inflammatory cytokines. We hypothesized that inhibition of activated astrocytes contributed to ameliorate depressive-like symptoms. Read More

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http://dx.doi.org/10.1016/j.jad.2018.08.015DOI Listing
January 2019
2 Reads

Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.

Oxid Med Cell Longev 2018 29;2018:7196142. Epub 2018 Jul 29.

Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Anadolu University, Eskisehir, Turkey.

Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety. Read More

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http://dx.doi.org/10.1155/2018/7196142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087606PMC
December 2018
3 Reads

Effects of antidepressants on parameters, melondiadehyde, and diphenyl-2-picryl-hydrazyl levels in mice spermatozoa.

Int J Reprod Biomed (Yazd) 2018 Jun;16(6):365-372

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Prescribing antidepressant drugs is becoming common. These drugs are known to affect sexual functions.

Objective: The study is aimed to assess the effects of amitriptyline and venlafaxine on sperm parameters and evaluate Malondialdehyde (MDA) and 1, 1-Diphenyl-2-picryl-hydrazyl values in BALB/ mice spermatozoa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079312PMC
June 2018
15 Reads

Serotonin Toxicity and Urinary Analgesics: A Case Report and Systematic Literature Review of Methylene Blue-Induced Serotonin Syndrome.

Psychosomatics 2018 11 3;59(6):539-546. Epub 2018 Jul 3.

James A. Haley Veterans' Hospital, Mental Health and Behavioral Sciences Service, University of South Florida, Psychiatry and Behavioral Neurosciences, Tampa, FL; University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA.

Background: Serotonin syndrome (SS) is a potentially serious side effect of serotonergic drugs. Cases of SS have been reported from the administration of methylene blue (MB), an agent with monoamine oxidase inhibiting properties. To date, the reported cases of MB-induced SS have all been with MB given parenterally. Read More

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http://dx.doi.org/10.1016/j.psym.2018.06.012DOI Listing
November 2018
9 Reads

Effects of waterborne exposure to the antidepressant fluoxetine on swimming, shoaling and anxiety behaviours of the mosquitofish Gambusia holbrooki.

Ecotoxicol Environ Saf 2018 Nov 7;163:646-655. Epub 2018 Aug 7.

Laboratorio de Ecotoxicología Acuática, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina; Instituto de Biodiversidad y Biología Experimental y Aplicada, CONICET-UBA, Ciudad Autónoma de Buenos Aires, Argentina.

Chemical pollution from pharmaceuticals is increasingly recognized as a major hazard to the aquatic biota. Among the wide variety of pharmaceuticals, fluoxetine (FLX) is one of the most widely prescribed antidepressants, and therefore, it is frequently identified in the aquatic environment. As FLX is designed to alter human behaviour and many physiological pathways are conserved across vertebrates, this drug may affect the behaviour of fish living in FLX-polluted environments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.07.085DOI Listing
November 2018
2 Reads

Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy.

Int J Nanomedicine 2018 23;13:4319-4331. Epub 2018 Jul 23.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China,

Background: Photodynamic therapy is a safe, noninvasive modality for cancer therapy, in which the photosensitizer (PS) is a crucial component. Hypericin (Hy) is a promising PS; however, its clinical application is significantly limited by its poor hydrophilicity.

Materials And Methods: To overcome the clinical application limitation of Hy, a novel strategy is developed here by entrapping Hy into polydopamine (PDA) film formed on the surface of magnetic iron oxide nanoparticles (MNPs) through the self-polymerization of dopamine under alkaline condition. Read More

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https://www.dovepress.com/facile-fabrication-of-hypericin-en
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http://dx.doi.org/10.2147/IJN.S161262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061409PMC
September 2018
8 Reads

Molybdenum bupropion combined neurotoxicity in rats.

Regul Toxicol Pharmacol 2018 Oct 3;98:224-230. Epub 2018 Aug 3.

Pathology Department, Egypt; Faculty of Medicine, Mansoura University, Egypt.

Heavy metal toxicity is a common foodborne problem in Egypt, especially in combination. Molybdenum toxicity has been studied as a model of the heavy metal toxicity. Molybdenum could promote toxicity via oxidative-inflammatory mechanisms. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.08.001DOI Listing
October 2018
4 Reads

Harms associated with extramedical use of prescription opioid analgesics in Australia: A scoping review.

Res Social Adm Pharm 2018 Jul 3. Epub 2018 Jul 3.

Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia; School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.

Background: Evidence is accumulating globally on harms from extramedical prescription opioid analgesic (POA) use.

Objective: The aim of this scoping review was to explore harms and documented risk factors associated with extramedical POA use in Australia.

Methods: MEDLINE, EMBASE, PsycINFO and CINAHL were searched for original studies published between January 2000 and February 2018. Read More

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http://dx.doi.org/10.1016/j.sapharm.2018.07.001DOI Listing
July 2018
3 Reads

Characteristics of Tianeptine Exposures Reported to the National Poison Data System - United States, 2000-2017.

MMWR Morb Mortal Wkly Rep 2018 Aug 3;67(30):815-818. Epub 2018 Aug 3.

Tianeptine (marketed as Coaxil or Stablon) is an atypical tricyclic drug used as an antidepressant in Europe, Asia, and Latin America. In the United States, tianeptine is not approved by the Food and Drug Administration (FDA) for medical use and is an unscheduled pharmaceutical agent* (1). Animal and human studies show that tianeptine is an opioid receptor agonist (2). Read More

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http://dx.doi.org/10.15585/mmwr.mm6730a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072055PMC
August 2018
9 Reads

Dietary hydrogenated vegetable fat exacerbates the activation of kynurenine pathway caused by peripheral lipopolysaccharide immune challenge in aged mice.

Chem Biol Interact 2018 Sep 24;293:28-37. Epub 2018 Jul 24.

Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, Itaqui, RS, Brazil.

Sickness behavior is a normal immune response of body to fight infection, accompanied by endocrine and behavioral alterations. Lipopolysaccharide (LPS) causes sickness behavior in rodents through the increase of proinflammatory cytokines, generating peripheral inflammation and thus overactivation of kynurenine pathway (KP). In the present study we investigated the effects of dietary hydrogenated vegetable fat (HVF) in sickness behavior induced by LPS in aged mice. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.07.023DOI Listing
September 2018
20 Reads

Effects of dietary tryptophan supplementation in the acetic acid-induced colitis mouse model.

Food Funct 2018 Aug;9(8):4143-4152

Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, Hunan 410125, China.

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and is strongly associated with intestinal immunity and the microbiome. Tryptophan (Trp) is an inflammatory inhibitor and modulator of the intestinal microflora. We explored the serum profile of amino acids and the effects of diet supplementation with Trp (1. Read More

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http://dx.doi.org/10.1039/c8fo01025kDOI Listing
August 2018
7 Reads

Tianeptine Sodium: A Nootropic With Potentially Lethal Consequences.

Prim Care Companion CNS Disord 2018 Jul 19;20(4). Epub 2018 Jul 19.

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http://dx.doi.org/10.4088/PCC.17l02205DOI Listing
July 2018
1 Read

Acute, subchronic oral toxicity, and genotoxicity evaluations of LPM570065, a new potent triple reuptake inhibitor.

Regul Toxicol Pharmacol 2018 Oct 17;98:129-139. Epub 2018 Jul 17.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address:

In the current study, to support the safety of LPM570065 as a new potent triple reuptake inhibitors (TRIs), LPM570065 was investigated through a single- and 13-week repeated-dose oral toxicity evaluation and mutagenicity assays. In an acute toxicity evaluation, Sprague-Dawley (SD) rats were single administration at dose of 500, 1000 and 2000 mg/kg. The results suggested that two (2/20) and seven (7/20) animals were died in the 1000 and 2000 mg/kg group, respectively. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.07.011DOI Listing
October 2018
3 Reads

Temporal Profiles and Dose-Responsiveness of Side Effects with Escitalopram and Duloxetine in Treatment-Naïve Depressed Adults.

Behav Sci (Basel) 2018 Jul 17;8(7). Epub 2018 Jul 17.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA.

Side effect profiles of antidepressants are relevant to treatment selection and adherence among patients with major depressive disorder (MDD), but several clinically-relevant characteristics of side effects are poorly understood. We aimed to compare the side effect profiles of escitalopram and duloxetine, including frequencies, time to onset, duration, dose responsiveness, and impact on treatment outcomes. Side effects occurring in 211 treatment-naïve patients with MDD randomized to 12 weeks of treatment with flexibly-dosed escitalopram (10⁻20 mg/day) or duloxetine (30⁻60 mg/day) as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study were evaluated. Read More

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http://dx.doi.org/10.3390/bs8070064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071033PMC
July 2018
17 Reads

α- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences.

Brain Res Bull 2018 Sep 20;142:129-137. Epub 2018 Jul 20.

Programa de Pós-Graduação em Bioquímica e Bioprospecção (PPGBBio), Grupo de Pesquisa em Neurobiotecnologia - GPN, Universidade Federal de Pelotas, UFPel, Postal Code 96010-900, Pelotas, RS, Brazil; Programa de Pós-Graduação em Biotecnologia (PPGB), Grupo de Pesquisa em Neurobiotecnologia- GPN, Biotecnologia/Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address:

Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antinociceptive activities in animal models, without showing acute toxicity. In view of develop more effective treatments to comorbid pain and depression, the purpose of this study was to evaluate the behavioral and biochemical effects of PSAP on reserpine induced pain-depression dyad model in mice as well to analyze the interaction of PSAP with specific targets by molecular docking analysis. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.07.007DOI Listing
September 2018
8 Reads

Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression.

Eur J Med Chem 2018 Aug 10;156:381-393. Epub 2018 Jul 10.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China. Electronic address:

Depression is associated with high mortality and morbidity rates worldwide. By our random screening, it was first revealed that 23 magnolol derivatives were synthesized followed by in vitro and in vivo evaluation of their antidepressive potential. Compound 7c was found to be the most promising compound, with EC values of 396. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183058
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http://dx.doi.org/10.1016/j.ejmech.2018.07.027DOI Listing
August 2018
18 Reads