5,135 results match your criteria Toxicity Antidepressants


Comparison of Prioritisation Schemes for Human Pharmaceuticals in the Aquatic Environment.

Environ Sci Pollut Res Int 2018 Dec 4. Epub 2018 Dec 4.

School of Geography, University of Leeds, Woodhouse Lane, Leeds, West Yorkshire, LS2 9JT, UK.

Only a small proportion of pharmaceuticals available for commercial use have been monitored in the aquatic environment, and even less is known about the effects on organisms. With thousands of pharmaceuticals in use, it is not feasible to monitor or assess the effects of all of these compounds. Prioritisation schemes allow the ranking of pharmaceuticals based on their potential as environmental contaminants, allowing resources to be appropriately used on those which are most likely to enter the environment and cause greatest harm. Read More

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http://link.springer.com/10.1007/s11356-018-3834-9
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http://dx.doi.org/10.1007/s11356-018-3834-9DOI Listing
December 2018
5 Reads

Pharmacogenetics of Membrane Transporters of Tacrolimus in Solid Organ Transplantation.

Clin Pharmacokinet 2018 Nov 10. Epub 2018 Nov 10.

Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Rennes University Hospital, Rennes, France.

Membrane transporters play an essential role in the pharmacokinetics of drugs as they mediate exchanges between biological compartments. Tacrolimus is characterized by wide interpatient variability in terms of its pharmacokinetics that may in part be due to genetic factors. The pharmacogenetics of drug transporters is therefore a promising area to explore in the clinical pharmacology of tacrolimus. Read More

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http://dx.doi.org/10.1007/s40262-018-0717-7DOI Listing
November 2018
10 Reads

Accumulation, metabolite and active defence system responses of fluoxetine in zebrafish embryos: Influence of multiwalled carbon nanotubes with different functional groups.

Aquat Toxicol 2018 Dec 30;205:204-212. Epub 2018 Oct 30.

School of Hydraulic and Ecological Engineering, Nanchang Institute of Technology, Nanchang, 330099, China.

Studies on the bioavailability of organic contaminants adsorbed to nanomaterials are increasing. In this study, we investigated the interaction between fluoxetine (FLX) and three multiwalled carbon nanotubes (MWCNTs) with different functional groups in zebrafish (Danio rerio) embryos, focusing on the FLX accumulation, the formation of the metabolite norfluoxetine (NFLX), and the active defence system responses. The accumulation of FLX in zebrafish was intensified by MWCNTs (46-99%), which simultaneously facilitated the formation of the metabolite NFLX by 23-167%. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183085
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http://dx.doi.org/10.1016/j.aquatox.2018.10.018DOI Listing
December 2018
6 Reads

Tiansi Liquid Modulates Gut Microbiota Composition and Tryptophan⁻Kynurenine Metabolism in Rats with Hydrocortisone-Induced Depression.

Molecules 2018 Oct 31;23(11). Epub 2018 Oct 31.

School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Tiansi Liquid is a traditional Chinese herbal medicine used to treat depression; however, the underlying mechanisms remain unclear. Here, we examined the effect of Tiansi Liquid in a rat model of hydrocortisone-induced depression using behavioral testing, 16S rRNA high-throughput pyrosequencing and high-performance liquid chromatography-mass spectrometry-based metabolomics of the tryptophan (TRP)⁻kynurenine (KYN) pathway. Tiansi Liquid significantly improved the sucrose preference and exploratory behavior of the depressive rats. Read More

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http://www.mdpi.com/1420-3049/23/11/2832
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http://dx.doi.org/10.3390/molecules23112832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278342PMC
October 2018
4 Reads

Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague-Dawley rats.

Regul Toxicol Pharmacol 2018 Dec 23;100:45-51. Epub 2018 Oct 23.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Yantai University, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) have developed as novel antidepressants and have been determined to possess higher efficacy and less adverse effects compared to other antidepressants. Our previous studies have showed that LPM570065, a new potent TRI, is relatively nontoxic in acute, subchronic toxicity and genotoxicity evaluations. In the current study, toxicity of LPM570065 was further evaluated on the fertility and early embryonic development in Sprague-Dawley rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02732300183027
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http://dx.doi.org/10.1016/j.yrtph.2018.10.008DOI Listing
December 2018
7 Reads

The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats.

Pharmacol Rep 2018 Dec 21;70(6):1173-1179. Epub 2018 Jul 21.

Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil. Electronic address:

Background: The use of antidepressants in combination is common practice following non-response to single antidepressant agents. Nevertheless, the scientific literature lacks preclinical studies regarding the combined administration of antidepressants across multiple behavioral measures including, but not limited to, cognition. Hence, we aimed to determine the effects of paroxetine (PAR), venlafaxine (VEN) and bupropion (BUP) alone or combined (PAR+BUP or VEN+BUP) on spatial and affective memory tasks to advance the knowledge about the combined use of antidepressants in cognition. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.07.003DOI Listing
December 2018
2 Reads

Lithium disturbs homeostasis of essential microelements in erythrocytes of rats: Selenium as a protective agent?

Pharmacol Rep 2018 Dec 17;70(6):1168-1172. Epub 2018 May 17.

Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.

Background: Selenium is an essential element which shows protective properties against diverse harmful factors. Lithium compounds are widely used in medicine, but, in spite of undoubted beneficial effects, treatment with these compounds may lead to severe side effects, including renal, gastrointestinal, neurological, endocrine and metabolic disorders. This study was aimed at evaluating the influence of selenium and/or lithium on lithium, iron, zinc and copper content in rats' erythrocytes as well as estimate the action of additional selenium on lithium exposure effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17341140173079
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http://dx.doi.org/10.1016/j.pharep.2018.05.003DOI Listing
December 2018
1 Read

Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics.

Sci Total Environ 2019 Feb 1;650(Pt 2):2731-2741. Epub 2018 Oct 1.

Department of Civil and Environmental Engineering, National University of Singapore, Singapore. Electronic address:

While it is well known that fluoxetine is more toxic to aquatic organisms at high pH, the metabolic dysregulations related to observed pH-dependent effects are still poorly understood. In the present study, we utilized a gas chromatography mass spectrometry (GC-MS) based metabolomics approach to assess metabolomic profile changes in developing zebrafish embryos following exposure (2 hpf-96 hpf) to different concentrations of fluoxetine at three environmentally relevant pH values (7.0, 8. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.364DOI Listing
February 2019
3 Reads

Impact of the widespread pharmaceutical pollutant fluoxetine on behaviour and sperm traits in a freshwater fish.

Sci Total Environ 2019 Feb 24;650(Pt 2):1771-1778. Epub 2018 Sep 24.

Monash University, School of Biological Sciences, Melbourne 3800, Australia.

Pharmaceutical pollutants are detected in aquatic habitats and wildlife tissues globally. One widespread contaminant of major concern is the antidepressant fluoxetine, which can affect behavioural and physiological processes in non-target species. Despite this, effects of fluoxetine on wildlife behaviour have seldom been investigated across multiple fitness-related contexts, especially at environmentally realistic concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.09.294DOI Listing
February 2019
2 Reads

Nebenwirkungen der neuen Antidepressiva.

Fortschr Neurol Psychiatr 2018 Sep 24;86(9):592-603. Epub 2018 Sep 24.

One reason for the increasing use of new antidepressant drugs is due to a decreased toxicity compared to older agents. Nevertheless, there are still potentially dangerous side effects important to be considered. To improve treatment outcome it is therefore advantageous to obtain a detailed medical history, as well as to give specific information about the mechanisms of action of antidepressants before choosing the appropriate drug. Read More

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http://dx.doi.org/10.1055/a-0648-1760DOI Listing
September 2018
2 Reads

Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12220

Department of Rehabilitation Medicine, Daegu Fatima Hospital, Daegu, Republic of Korea.

Rationale: Venlafaxine is an antidepressant and anxiolytic agent that functions by inhibiting central serotonin and norepinephrine reuptake, and it is a relatively recently introduced drug. In particular, overdose of venlafaxine has been reported to cause severe cardiac toxicity including ventricular tachycardia, prolongation of QT interval, and seizure or severe muscular injury. However, reports describing venlafaxine-induced rhabdomyolysis with neuropathy remain scarce. Read More

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http://dx.doi.org/10.1097/MD.0000000000012220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155956PMC
September 2018
3 Reads

Exposure to low concentration of fluoxetine affects development, behaviour and acetylcholinesterase activity of zebrafish embryos.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 6;215:1-8. Epub 2018 Sep 6.

Laboratório de Genética Toxicológica, Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Asa Norte, 70910-900 Brasília, Distrito Federal, Brazil.

Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRI) antidepressant widely used in clinics and very often found in environmental samples of urban aquatic ecosystems in concentrations ranging from ng/L to μg/L. Fish populations might be especially susceptible to FLX due to the presence of conserved cellular receptors of serotonin. Neurotoxic effects on fish biota of polluted water bodies may be expected, but there are no sufficient studies in the current literature to elucidate this hypothesis. Read More

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http://dx.doi.org/10.1016/j.cbpc.2018.08.009DOI Listing
January 2019
4 Reads

Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.

Oxid Med Cell Longev 2018 29;2018:7196142. Epub 2018 Jul 29.

Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Anadolu University, Eskisehir, Turkey.

Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety. Read More

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http://dx.doi.org/10.1155/2018/7196142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087606PMC
December 2018
1 Read

Effects of antidepressants on parameters, melondiadehyde, and diphenyl-2-picryl-hydrazyl levels in mice spermatozoa.

Int J Reprod Biomed (Yazd) 2018 Jun;16(6):365-372

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Prescribing antidepressant drugs is becoming common. These drugs are known to affect sexual functions.

Objective: The study is aimed to assess the effects of amitriptyline and venlafaxine on sperm parameters and evaluate Malondialdehyde (MDA) and 1, 1-Diphenyl-2-picryl-hydrazyl values in BALB/ mice spermatozoa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079312PMC
June 2018
11 Reads

Serotonin Toxicity and Urinary Analgesics: A Case Report and Systematic Literature Review of Methylene Blue-Induced Serotonin Syndrome.

Psychosomatics 2018 Nov 3;59(6):539-546. Epub 2018 Jul 3.

James A. Haley Veterans' Hospital, Mental Health and Behavioral Sciences Service, University of South Florida, Psychiatry and Behavioral Neurosciences, Tampa, FL; University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA.

Background: Serotonin syndrome (SS) is a potentially serious side effect of serotonergic drugs. Cases of SS have been reported from the administration of methylene blue (MB), an agent with monoamine oxidase inhibiting properties. To date, the reported cases of MB-induced SS have all been with MB given parenterally. Read More

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http://dx.doi.org/10.1016/j.psym.2018.06.012DOI Listing
November 2018
8 Reads

Effects of waterborne exposure to the antidepressant fluoxetine on swimming, shoaling and anxiety behaviours of the mosquitofish Gambusia holbrooki.

Ecotoxicol Environ Saf 2018 Nov 7;163:646-655. Epub 2018 Aug 7.

Laboratorio de Ecotoxicología Acuática, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina; Instituto de Biodiversidad y Biología Experimental y Aplicada, CONICET-UBA, Ciudad Autónoma de Buenos Aires, Argentina.

Chemical pollution from pharmaceuticals is increasingly recognized as a major hazard to the aquatic biota. Among the wide variety of pharmaceuticals, fluoxetine (FLX) is one of the most widely prescribed antidepressants, and therefore, it is frequently identified in the aquatic environment. As FLX is designed to alter human behaviour and many physiological pathways are conserved across vertebrates, this drug may affect the behaviour of fish living in FLX-polluted environments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.07.085DOI Listing
November 2018
1 Read

Facile fabrication of hypericin-entrapped glyconanoparticles for targeted photodynamic therapy.

Int J Nanomedicine 2018 23;13:4319-4331. Epub 2018 Jul 23.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China,

Background: Photodynamic therapy is a safe, noninvasive modality for cancer therapy, in which the photosensitizer (PS) is a crucial component. Hypericin (Hy) is a promising PS; however, its clinical application is significantly limited by its poor hydrophilicity.

Materials And Methods: To overcome the clinical application limitation of Hy, a novel strategy is developed here by entrapping Hy into polydopamine (PDA) film formed on the surface of magnetic iron oxide nanoparticles (MNPs) through the self-polymerization of dopamine under alkaline condition. Read More

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https://www.dovepress.com/facile-fabrication-of-hypericin-en
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http://dx.doi.org/10.2147/IJN.S161262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061409PMC
September 2018
7 Reads

Molybdenum bupropion combined neurotoxicity in rats.

Regul Toxicol Pharmacol 2018 Oct 3;98:224-230. Epub 2018 Aug 3.

Pathology Department, Egypt; Faculty of Medicine, Mansoura University, Egypt.

Heavy metal toxicity is a common foodborne problem in Egypt, especially in combination. Molybdenum toxicity has been studied as a model of the heavy metal toxicity. Molybdenum could promote toxicity via oxidative-inflammatory mechanisms. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.08.001DOI Listing
October 2018
2 Reads

Harms associated with extramedical use of prescription opioid analgesics in Australia: A scoping review.

Res Social Adm Pharm 2018 Jul 3. Epub 2018 Jul 3.

Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia; School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.

Background: Evidence is accumulating globally on harms from extramedical prescription opioid analgesic (POA) use.

Objective: The aim of this scoping review was to explore harms and documented risk factors associated with extramedical POA use in Australia.

Methods: MEDLINE, EMBASE, PsycINFO and CINAHL were searched for original studies published between January 2000 and February 2018. Read More

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http://dx.doi.org/10.1016/j.sapharm.2018.07.001DOI Listing
July 2018
2 Reads

Characteristics of Tianeptine Exposures Reported to the National Poison Data System - United States, 2000-2017.

MMWR Morb Mortal Wkly Rep 2018 Aug 3;67(30):815-818. Epub 2018 Aug 3.

Tianeptine (marketed as Coaxil or Stablon) is an atypical tricyclic drug used as an antidepressant in Europe, Asia, and Latin America. In the United States, tianeptine is not approved by the Food and Drug Administration (FDA) for medical use and is an unscheduled pharmaceutical agent* (1). Animal and human studies show that tianeptine is an opioid receptor agonist (2). Read More

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http://dx.doi.org/10.15585/mmwr.mm6730a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072055PMC
August 2018
7 Reads

Dietary hydrogenated vegetable fat exacerbates the activation of kynurenine pathway caused by peripheral lipopolysaccharide immune challenge in aged mice.

Chem Biol Interact 2018 Sep 24;293:28-37. Epub 2018 Jul 24.

Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, Itaqui, RS, Brazil.

Sickness behavior is a normal immune response of body to fight infection, accompanied by endocrine and behavioral alterations. Lipopolysaccharide (LPS) causes sickness behavior in rodents through the increase of proinflammatory cytokines, generating peripheral inflammation and thus overactivation of kynurenine pathway (KP). In the present study we investigated the effects of dietary hydrogenated vegetable fat (HVF) in sickness behavior induced by LPS in aged mice. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.07.023DOI Listing
September 2018
11 Reads

Effects of dietary tryptophan supplementation in the acetic acid-induced colitis mouse model.

Food Funct 2018 Aug;9(8):4143-4152

Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, Hunan 410125, China.

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and is strongly associated with intestinal immunity and the microbiome. Tryptophan (Trp) is an inflammatory inhibitor and modulator of the intestinal microflora. We explored the serum profile of amino acids and the effects of diet supplementation with Trp (1. Read More

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http://dx.doi.org/10.1039/c8fo01025kDOI Listing
August 2018
5 Reads

Tianeptine Sodium: A Nootropic With Potentially Lethal Consequences.

Prim Care Companion CNS Disord 2018 Jul 19;20(4). Epub 2018 Jul 19.

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http://dx.doi.org/10.4088/PCC.17l02205DOI Listing

Acute, subchronic oral toxicity, and genotoxicity evaluations of LPM570065, a new potent triple reuptake inhibitor.

Regul Toxicol Pharmacol 2018 Oct 17;98:129-139. Epub 2018 Jul 17.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address:

In the current study, to support the safety of LPM570065 as a new potent triple reuptake inhibitors (TRIs), LPM570065 was investigated through a single- and 13-week repeated-dose oral toxicity evaluation and mutagenicity assays. In an acute toxicity evaluation, Sprague-Dawley (SD) rats were single administration at dose of 500, 1000 and 2000 mg/kg. The results suggested that two (2/20) and seven (7/20) animals were died in the 1000 and 2000 mg/kg group, respectively. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.07.011DOI Listing
October 2018
1 Read

Temporal Profiles and Dose-Responsiveness of Side Effects with Escitalopram and Duloxetine in Treatment-Naïve Depressed Adults.

Behav Sci (Basel) 2018 Jul 17;8(7). Epub 2018 Jul 17.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA.

Side effect profiles of antidepressants are relevant to treatment selection and adherence among patients with major depressive disorder (MDD), but several clinically-relevant characteristics of side effects are poorly understood. We aimed to compare the side effect profiles of escitalopram and duloxetine, including frequencies, time to onset, duration, dose responsiveness, and impact on treatment outcomes. Side effects occurring in 211 treatment-naïve patients with MDD randomized to 12 weeks of treatment with flexibly-dosed escitalopram (10⁻20 mg/day) or duloxetine (30⁻60 mg/day) as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study were evaluated. Read More

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http://dx.doi.org/10.3390/bs8070064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071033PMC
July 2018
15 Reads

α- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences.

Brain Res Bull 2018 Sep 20;142:129-137. Epub 2018 Jul 20.

Programa de Pós-Graduação em Bioquímica e Bioprospecção (PPGBBio), Grupo de Pesquisa em Neurobiotecnologia - GPN, Universidade Federal de Pelotas, UFPel, Postal Code 96010-900, Pelotas, RS, Brazil; Programa de Pós-Graduação em Biotecnologia (PPGB), Grupo de Pesquisa em Neurobiotecnologia- GPN, Biotecnologia/Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address:

Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antinociceptive activities in animal models, without showing acute toxicity. In view of develop more effective treatments to comorbid pain and depression, the purpose of this study was to evaluate the behavioral and biochemical effects of PSAP on reserpine induced pain-depression dyad model in mice as well to analyze the interaction of PSAP with specific targets by molecular docking analysis. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.07.007DOI Listing
September 2018
6 Reads

Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression.

Eur J Med Chem 2018 Aug 10;156:381-393. Epub 2018 Jul 10.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China. Electronic address:

Depression is associated with high mortality and morbidity rates worldwide. By our random screening, it was first revealed that 23 magnolol derivatives were synthesized followed by in vitro and in vivo evaluation of their antidepressive potential. Compound 7c was found to be the most promising compound, with EC values of 396. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183058
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http://dx.doi.org/10.1016/j.ejmech.2018.07.027DOI Listing
August 2018
12 Reads

Serotonin Syndrome in the Perioperative Setting.

Am J Case Rep 2018 Jul 16;19:833-835. Epub 2018 Jul 16.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications. As the use of antidepressant medications has increased, the incidence of perioperative serotonin syndrome has transitioned from a rare diagnosis to one that should be considered as a differential diagnosis for any patient displaying signs of neuroexcitation. CASE REPORT A 70-year-old man (ASA 2) with a history of vestibular migraines (treated with venlafaxine), gastroesophageal reflux disease, and benign prostatic hyperplasia presented to our institution for photoselective vaporization of the prostate. Read More

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http://dx.doi.org/10.12659/AJCR.909497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061453PMC
July 2018
14 Reads

Tricyclic antidepressants inhibit Candida albicans growth and biofilm formation.

Int J Antimicrob Agents 2018 Oct 7;52(4):500-505. Epub 2018 Jul 7.

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy; Interdepartmental Centre SITEIA.PARMA, University of Parma, Parma, Italy.

Candida albicans is a commensal yeast of the human body, able to form biofilms on solid surfaces such as implanted medical devices, and contributes to nosocomial infections. Biofilms have the capacity to resist higher levels of antifungals compared with planktonic cells, and can develop tolerance to commonly used treatments. The necessity to overcome acquired drug resistance and identify new active molecules with low toxicity is a significant problem. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.06.023DOI Listing
October 2018
2 Reads

Involvement of prelimbic 5-HT receptors in the regulation of anxiety-like behaviors in hemiparkinsonian rats.

Neurol Res 2018 Oct 10;40(10):847-855. Epub 2018 Jul 10.

a Department of Physiology and Pathophysiology, School of Basic Medical Sciences , Xi'an Jiaotong University Health Science Center , Xi'an , China.

Objective: At present, little is known about the role of serotonin (5-HT) receptor in anxiety, particularly in Parkinson's disease-related anxiety. Here, we tested whether 5-HT receptors in the prelimbic (PrL) cortex are involved in the regulation of anxiety-like behaviors in sham-operated rats and rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle (MFB).

Methods: The open field and elevated plus maze (EPM) tests were performed to study the influence of MFB lesion and intra-PrL injection of 5-HT agonist AS19 (0. Read More

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http://dx.doi.org/10.1080/01616412.2018.1493962DOI Listing
October 2018
2 Reads
1.450 Impact Factor

Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice.

Eur J Pharmacol 2018 Aug 4;833:451-461. Epub 2018 Jul 4.

Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil. Electronic address:

Depression is one of the most frequent neuropsychiatric diseases in the western world and its physiological causes are not yet fully understood. Since the available antidepressants failed to provide a complete illness remission, the diversification of the therapy in the management of depression could be a useful contribution. The present study aimed to investigate the cholecalciferol capability to revert depressive-like behavior induced by chronic corticosterone (CORT) treatment in mice and its implication on the oxidative stress modulation. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.07.002DOI Listing
August 2018
2 Reads

Indoleamine 2,3-Dioxygenase (IDO) Inhibition as a Strategy to Augment Cancer Immunotherapy.

BioDrugs 2018 Aug;32(4):311-317

Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Health System, 1500 E. Medical Center Drive, C369 Med Inn Building, SPC 5848, Ann Arbor, MI, 48109, USA.

Indoleamine 2,3-dioxygenase (IDO) is an enzyme of interest in immuno-oncology because of the immunosuppressive effects that result from its role in tryptophan catabolism. IDO is upregulated in malignancy and is associated with poor prognosis in multiple cancer types. IDO inhibitors have been developed to target IDO, both directly and indirectly. Read More

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http://dx.doi.org/10.1007/s40259-018-0291-4DOI Listing
August 2018
3 Reads

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion.

Amino Acids 2018 Oct 5;50(10):1377-1390. Epub 2018 Jul 5.

AIMMS, Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HZ, Amsterdam, The Netherlands.

In yeast, toxicity of acetaminophen (APAP), a frequently used analgesic and antipyretic drug, depends on ubiquitin-controlled processes. Previously, we showed a remarkable overlap in toxicity profiles between APAP and tyrosine, and a similarity with drugs like rapamycin and quinine, which induce degradation of the amino acid permease Tat2. Therefore, we investigated in yeast whether APAP reduced the expression levels of amino acid permeases. Read More

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http://dx.doi.org/10.1007/s00726-018-2613-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153950PMC
October 2018
1 Read

Validation of a simple, fast liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of 40 antidepressant drugs or their metabolites in plasma.

Clin Chim Acta 2018 Oct 13;485:243-257. Epub 2018 Jul 13.

Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. Electronic address:

Introduction: Antidepressant (AD) use has increased significantly over the last decades. Therapeutic drug monitoring is recommended for compliance, toxicity and treatment efficiency. ADs also show a high prevalence in forensic cases. Read More

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http://dx.doi.org/10.1016/j.cca.2018.06.047DOI Listing
October 2018
3 Reads

Drug-to-drug interactions of tyrosine kinase inhibitors in chronic myeloid leukemia patients. Is it a real problem?

Ann Hematol 2018 Nov 28;97(11):2089-2098. Epub 2018 Jun 28.

Servicio de Hematología, Hospital Universitario de la Princesa, Madrid, Spain.

With tyrosine kinase inhibitors (TKI), chronic myeloid leukemia (CML) patients are achieving similar rates of survival to the general population and some treatment aspects such as adherence and drug-to-drug interactions (DDI) are becoming increasingly important. Our aim was to investigate the frequency and real clinical consequences of DDI between TKI and concurrent medications in CML. We performed a retrospective multicenter study including 105 patients receiving 134 TKI treatments. Read More

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http://dx.doi.org/10.1007/s00277-018-3413-7DOI Listing
November 2018
7 Reads

Efficient Intracellular Delivery of Cell-Impermeable Cargo Molecules by Peptides Containing Tryptophan and Histidine.

Molecules 2018 Jun 26;23(7). Epub 2018 Jun 26.

Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA 92618, USA.

We have previously evaluated and reported numerous classes of linear and cyclic peptides containing hydrophobic and hydrophilic segments for intracellular delivery of multiple molecular cargos. Herein, a combination of histidine and tryptophan amino acids were designed and evaluated for their efficiency in intracellular delivery of cell-impermeable phosphopeptides and the anti-HIV drug, emtricitabine. Two new decapeptides, with linear and cyclic natures, both containing alternate tryptophan and histidine residues, were synthesized using Fmoc/tBu solid-phase chemistry. Read More

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http://www.mdpi.com/1420-3049/23/7/1536
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http://dx.doi.org/10.3390/molecules23071536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100250PMC
June 2018
16 Reads
2.420 Impact Factor

Neuropathic cancer pain: prevalence, pathophysiology, and management.

Korean J Intern Med 2018 Nov 25;33(6):1058-1069. Epub 2018 Jun 25.

Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.

Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. Read More

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http://dx.doi.org/10.3904/kjim.2018.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234399PMC
November 2018
1 Read

Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects.

Authors:
Brian A Baldo

Arch Toxicol 2018 Aug 18;92(8):2457-2473. Epub 2018 Jun 18.

Molecular Immunology Unit, Department of Medicine, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, University of Sydney, Sydney, NSW, Australia.

Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic levels of serotonin, and opioid analgesic drugs are now recognized as being involved in some cases of serotonin toxicity especially if administered in conjunction with other serotonergic medications including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants. In March 2016, the FDA issued a Drug Safety Communication concerning the association of the entire class of opioid pain medicines with serotonin toxicity. Read More

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http://dx.doi.org/10.1007/s00204-018-2244-6DOI Listing
August 2018
9 Reads

Effect of co-administration of two different phosphodiesterase inhibitors and a β-adrenoceptor agonist in an experimental model of detrusor overactivity.

Eur J Pharmacol 2018 Aug 18;833:425-431. Epub 2018 Jun 18.

Division of Urology, Universidade Federal do Ceara, Brazil. Electronic address:

The purpose of this study was to evaluate in vitro the effect of the combination of BRL 37344 (ß-adrenoceptor agonist) with tadalafil (phosphodiesterase type 5 inhibitor) or rolipram (phosphodiesterase type 4 inhibitor) in an experimental model of detrusor overactivity. The experiments were carried out in two phases using bladder strips of mice. In the first phase, on the top of 40 mM potassium-induced contraction, strips isolated from control mice were exposed to increasing concentrations of each study drug. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.06.018DOI Listing
August 2018
1 Read

Clomipramine Toxicity in a CYP 2D6 Poor Metabolizer Patient Who Suddenly Stopped Smoking.

J Clin Psychopharmacol 2018 08;38(4):389-391

Department of Clinical Pharmacy St Antonius Hospital Nieuwegein, The Netherlands Department of Clinical Psychiatry St Antonius Hospital Nieuwegein, The Netherlands Department of Clinical Pharmacy St Antonius Hospital Nieuwegein, The Netherlands

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http://dx.doi.org/10.1097/JCP.0000000000000896DOI Listing

Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant.

Toxicol Sci 2018 Oct;165(2):372-388

Developmental and Reproductive Biology Graduate Program, Institute for Biogenesis Research, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii 96813.

Fluoxetine is one of the most commonly prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Epidemiologic studies have suggested a link between maternal fluoxetine use during pregnancy and an increased incidence of birth defects. However, the mechanisms by which fluoxetine adversely impacts embryonic developments are unknown. Read More

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http://dx.doi.org/10.1093/toxsci/kfy143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154268PMC
October 2018
6 Reads