3,964 results match your criteria Toxicity Anticholinergic


Eslicarbazepine acetate reduces trigeminal nociception: Possible role of adrenergic, cholinergic and opioid receptors.

Life Sci 2018 Dec 27;214:167-175. Epub 2018 Oct 27.

Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, P.O. Box 146, 11221 Belgrade, Serbia.

Aims: Eslicarbazepine acetate (ESL) is a novel dibenzazepine antiepileptic, that has demonstrated efficacy against trigeminal pain, both in preclinical and clinical studies. However, ESL's mechanism of antinociceptive action remains uncertain. Here, we aimed to examine the contribution of adrenergic/cholinergic/opioid receptors to the antinociceptive effects of ESL in a trigeminal pain model, as these neurotransmitter systems are known to have an important role in the modulation of trigeminal nociception. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00243205183069
Publisher Site
http://dx.doi.org/10.1016/j.lfs.2018.10.059DOI Listing
December 2018
7 Reads

Demystifying serotonin syndrome (or ).

Can Fam Physician 2018 Oct;64(10):720-727

Assistant Professor and Acting Director of the Doctor of Pharmacy program at the Leslie Dan Faculty of Pharmacy at the University of Toronto in Ontario, an advanced practice hospital pharmacist at the Centre for Addiction and Mental Health in Toronto, a doctoral candidate in the School of Health Professions Education at Maastricht University in the Netherlands, and a research fellow at the Wilson Centre in Toronto.

Objective: To review the symptoms of serotonin toxicity (commonly referred to as ) and the causative drugs and their mechanisms of action, and to equip primary care providers with practical strategies to prevent and identify serotonin toxicity.

Quality Of Evidence: PubMed and Google Scholar were searched for relevant articles on serotonin toxicity, the causes, and the differential diagnosis using search terms related to serotonin toxicity (), causes (individual names of drug classes, individual drug names), and diagnosis (). Experts in psychiatric medicine, psychiatric pharmacy, clinical pharmacology, and medical toxicology were consulted. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184959PMC
October 2018
2 Reads

Efficacy of antidotes and their combinations in the treatment of acute carbamate poisoning in rats.

Toxicology 2018 Sep 1;408:113-124. Epub 2018 Sep 1.

Department of Anatomy and Forensic Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Background: Physostigmine and its analogues neostigmine, pyridostigmine and rivastigmine are carbamates nowadays used in many indications, including antidotal effects against antimuscarinic poisonings, reversal of competitive neuromuscular block, myasthenia gravis, Alzheimer's disease and prophylaxis against nerve agent intoxications. Use of these medicinal carbamates, but also of carbamate insecticides, created need for research into the potential and mechanisms of action of several antidotes against carbamate poisonings, including anticholinergics and oximes.

Aim: The goal of this experimental study was to ascertain the life-preserving potential of anticholinergics atropine, hexamethonium and d-tubocurarine, oxime HI-6 and their combinations in rats poisoned with physostigmine or pyridostigmine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tox.2018.08.017DOI Listing
September 2018
25 Reads

Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman.

Toxicol Lett 2018 Nov 27;297:19-23. Epub 2018 Aug 27.

Experimental Anesthesiology Section, Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls-University, Waldhoernlestrasse 22, 72072 Tuebingen, Germany. Electronic address:

Intoxication with organophosphorus compounds can result in life-threatening organ dysfunction and refractory seizures. Sedation or hypnosis is essential to facilitate mechanical ventilation and control seizure activity. The range of indications for midazolam includes both hypnosis and seizure control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2018.08.016DOI Listing
November 2018
18 Reads

Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.

Eur J Med Chem 2018 Sep 4;157:161-176. Epub 2018 Aug 4.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address:

The multifactorial nature of Alzheimer's disease (AD) calls for the development of multitarget agents addressing key pathogenic processes. A novel family of donepezil-butylated hydroxytoluene (BHT) hybrids were designed, synthesized and evaluated as multifunctional ligands against AD. The optimal compound 7d displayed a balanced multifunctional profile covering an intriguing acetylcholinesterase (AChE) inhibition (IC 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2018.08.005DOI Listing
September 2018
11 Reads
3.450 Impact Factor

New insights into the organophosphate-induced intermediate syndrome.

Arh Hig Rada Toksikol 2018 Jun;69(2):191-195

Department of Internal Medicine and Toxicology, "Sf. Spiridon" Clinical Emergency Hospital, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, Romania.

Acute organophosphate (OP) poisoning can be deadlier than any other type of chemical poisoning. So far, only a few cases have been described that include extensive neurological complications. We present an outstanding case of severe oral OP poisoning with intermediate syndrome developed on the fourth day after hospital admission. Read More

View Article

Download full-text PDF

Source
http://content.sciendo.com/view/journals/aiht/69/2/article-p
Publisher Site
http://dx.doi.org/10.2478/aiht-2018-69-3121DOI Listing
June 2018
3 Reads

Antiapoptotic effects of vitamins C and E against cypermethrin-induced oxidative stress and spermatogonial germ cell apoptosis.

J Biochem Mol Toxicol 2018 Aug 5;32(8):e22174. Epub 2018 Jul 5.

Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra, 136 119, India.

Toxicological studies have demonstrated the relation between use of agrochemicals and fertility issues within males. Thus, the present study aimed to elucidate the propensity of cypermethrin (CYP) in bringing testicular germ cell apoptosis and effective attenuation by vitamins C and E in caprines. Reproductive toxicity of CYP was evaluated using histomorphological, cytological, and biochemical changes in the testicular germ cells in dose-dependent (1, 5, 10 μg/mL) and time-dependent (4, 6, 8 h) manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbt.22174DOI Listing
August 2018
5 Reads

Extracorporeal Cardiopulmonary Resuscitation After Diphenhydramine Ingestion.

J Med Toxicol 2018 Sep 28;14(3):253-256. Epub 2018 Jun 28.

Department of Pediatrics, Section of Critical Care Medicine, Baylor College of Medicine, Texas Children's Hospital, 6651 Main Street, Houston, TX, 77030, USA.

Introduction: Diphenhydramine is a widely used first-generation histamine (H) antagonist that can be obtained without prescription in many countries. Massive ingestions can result in severe toxicity and even death. We describe a case of diphenhydramine overdose leading to cardiac arrest, cardiopulmonary resuscitation (CPR), and extracorporeal membrane oxygenation (ECMO) cannulation for refractory ventricular fibrillation, a process we refer to as extracorporeal cardiopulmonary resuscitation (ECPR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13181-018-0672-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097973PMC
September 2018
13 Reads

Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.

Pharm Biol 2018 Dec;56(1):309-317

a College of Natural Resources & Life Science/Life and Industry Convergence Research Institute , Pusan National University , Miryang , Korea.

Context: Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, the prevention of histamine release and modulation of CaCC chloride channel.

Objective: We investigated the laxative effect and action mechanism of QCT in Lop-induced constipation model.

Materials And Methods: Constipation of SD rats was induced by subcutaneous injection of loperamide (Lop) (4 mg/kg weight) in 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13880209.2018.1474932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130520PMC
December 2018
9 Reads
1.340 Impact Factor

ameliorates scopolamine-induced amnesia in rats: Behavioral, biochemical, and molecular evidence.

Indian J Pharmacol 2018 Jan-Feb;50(1):30-38

Department of Veterinary Public Health, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India.

Objective: Hydroethanolic extract of seeds (HEZA) in scopolamine-induced amnesia was investigated for memory enhancing activity.

Materials And Methods: Radial arm maze (RAM) test was performed to evaluate the behavioral activity. Rats were treated with HEZA (50, 100, and 200 mg/kg, p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijp.IJP_417_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954630PMC
October 2018
6 Reads

Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization.

Authors:
Oleg E Osadchii

Scand Cardiovasc J 2018 08 25;52(4):218-226. Epub 2018 May 25.

a Department of Biomedical Sciences , University of Copenhagen , Copenhagen , Denmark.

Objectives: In normal conditions, sudden heart rate acceleration provokes a rapid reduction in ventricular action potential duration (APD). The protracted APD rate adaptation favors early afterdepolarizations and precipitates arrhythmia. Nevertheless, it is uncertain as to whether the rate-dependent changes of ventricular repolarization can be adversely modified by arrhythmogenic drugs (quinidine and procainamide) and hypokalemia, in comparison to the agents with safe therapeutic profile, such as lidocaine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14017431.2018.1478123DOI Listing
August 2018
1 Read

The evaluation of acute physiology and chronic health evaluation II score, poisoning severity score, sequential organ failure assessment score combine with lactate to assess the prognosis of the patients with acute organophosphate pesticide poisoning.

Medicine (Baltimore) 2018 May;97(21):e10862

Department of Emergency Medicine, Chao-Yang Hospital Affiliated to Capital Medical University, Beijing.

The aim of this study was to assess the ability of acute physiology and chronic health evaluation II (APACHE II) score, poisoning severity score (PSS) as well as sequential organ failure assessment (SOFA) score combining with lactate (Lac) to predict mortality in the Emergency Department (ED) patients who were poisoned with organophosphate.A retrospective review of 59 stands-compliant patients was carried out. Receiver operating characteristic (ROC) curves were constructed based on the APACHE II score, PSS, SOFA score with or without Lac, respectively, and the areas under the ROC curve (AUCs) were determined to assess predictive value. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000010862DOI Listing
May 2018
2 Reads

Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats.

Toxicol Lett 2018 Sep 26;294:73-86. Epub 2018 May 26.

Laboratory of Toxicology-Microbiology and Environmental Health, UR11ES70, Sciences Faculty of Sfax, University of Sfax, BP1171, 3000, Sfax, Tunisia. Electronic address:

Bifenthrin (BF) is a synthetic pyrethroid pesticide widely used in several countries to manage insect pests on diverse agricultural crops. Growing evidence indicates that BF exposure is associated with an increased risk of developing neurodegenerative disorders. However, the mechanisms by which BF induces neurological and anxiety alterations in the frontal cortex and striatum are not well known. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03784274183020
Publisher Site
http://dx.doi.org/10.1016/j.toxlet.2018.05.020DOI Listing
September 2018
9 Reads

Anticholinergic Toxicity Secondary to Overuse of Topricin Cream, a Homeopathic Medication.

Cureus 2018 Mar 5;10(3):e2273. Epub 2018 Mar 5.

Emergency Medicine, Staten Island University Hospital.

Adverse reactions from over-the-counter medications present a challenge to physicians. Homeopathic medicine is an alternative practice, originating in Germany and gaining popularity in the United States. It utilizes dilute preparations of substances in order to treat and cure disease. Read More

View Article

Download full-text PDF

Source
https://www.cureus.com/articles/10841-anticholinergic-toxici
Publisher Site
http://dx.doi.org/10.7759/cureus.2273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935428PMC
March 2018
6 Reads

Antinociceptive Activity of Methanolic Extract of Leaves: Possible Mechanisms of Action Involved.

Pain Res Manag 2018 4;2018:9536406. Epub 2018 Mar 4.

Department of Veterinary Pre-Clinical Sciences, Faculty of Veterinary Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Methanolic extract of Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using various nociceptive assays. The antinociceptive activity of MECN was (i) tested against capsaicin-, glutamate-, phorbol 12-myristate 13-acetate-, bradykinin-induced nociception model; (ii) prechallenged against selective antagonist of opioid receptor subtypes (-funaltrexamine, naltrindole, and nor-binaltorphimine); (iii) prechallenged against antagonist of nonopioid systems, namely, -noradrenergic (yohimbine), -adrenergic (pindolol), adenosinergic (caffeine), dopaminergic (haloperidol), and cholinergic (atropine) receptors; (iv) prechallenged with inhibitors of various potassium channels (glibenclamide, apamin, charybdotoxin, and tetraethylammonium chloride). Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/prm/2018/9536406/
Publisher Site
http://dx.doi.org/10.1155/2018/9536406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857305PMC
September 2018
8 Reads

Physostigmine Reversal of Dysarthria and Delirium After Iatrogenic Atropine Overdose From a Dental Procedure.

J Emerg Med 2018 06 19;54(6):e113-e115. Epub 2018 Apr 19.

Department of Emergency Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota.

Background: Sublingual atropine, dosed at 0.4-0.8 mg, is used by dentists as an antisialogogue to facilitate and increase the speed of procedures. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07364679183023
Publisher Site
http://dx.doi.org/10.1016/j.jemermed.2018.02.046DOI Listing
June 2018
5 Reads

Phencyclidine and Scopolamine for Modeling Amnesia in Rodents: Direct Comparison with the Use of Barnes Maze Test and Contextual Fear Conditioning Test in Mice.

Neurotox Res 2018 Oct 21;34(3):431-441. Epub 2018 Apr 21.

Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna St., 30 - 688, Krakow, Poland.

Nowadays cognitive impairments are a growing unresolved medical issue which may accompany many diseases and therapies, furthermore, numerous researchers investigate various neurobiological aspects of human memory to find possible ways to improve it. Until any other method is discovered, in vivo studies remain the only available tool for memory evaluation. At first, researchers need to choose a model of amnesia which may strongly influence observed results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-018-9901-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154175PMC
October 2018
1 Read

[The distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration].

Sud Med Ekspert 2018;61(2):36-44

Department of Pharmaceutical, Toxicological and Аnalytical Chemistry, Kursk State Medical University, Ministry of Health of the Russia, Kursk, Russia, 305041.

The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/sudmed201861236-44DOI Listing
September 2018
1 Read

Atropa belladonna neurotoxicity: Implications to neurological disorders.

Food Chem Toxicol 2018 Jun 10;116(Pt B):346-353. Epub 2018 Apr 10.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:

Atropa belladonna, commonly known as belladonna or deadly nightshade, ranks among one of the most poisonous plants in Europe and other parts of the world. The plant contains tropane alkaloids including atropine, scopolamine, and hyoscyamine, which are used as anticholinergics in Food and Drug Administration (FDA) approved drugs and homeopathic remedies. These alkaloids can be very toxic at high dose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2018.04.022DOI Listing
June 2018
2 Reads

In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development.

ACS Chem Neurosci 2018 Jun 14;9(6):1441-1452. Epub 2018 Mar 14.

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Veterinaria , Universidad de Santiago de Compostela , 27001 Lugo , Spain.

Spirolides (SPX) are marine toxins, produced by dinoflagellates that act as potent antagonists of nicotinic acetylcholine receptors. These compounds are not toxic for humans, and since there are no reports of human intoxications caused by this group of toxins they are not yet currently regulated in Europe. Currently 13-desmethyl spirolide C, 13,19-didesmethyl spirolide C, and 20-methyl spirolide G are commercially available as reference materials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.8b00036DOI Listing

Oxidative stress in organophosphate poisoning: role of standard antidotal therapy.

J Appl Toxicol 2018 Aug 8;38(8):1058-1070. Epub 2018 Mar 8.

Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.

Despite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Oxidative stress is among the most intensively studied. Overstimulation of cholinergic and glutamatergic nervous system is followed by intensified generation of reactive species and oxidative damage in many tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3605DOI Listing
August 2018
7 Reads

Acute radiation impacts contractility of guinea-pig bladder strips affecting mucosal-detrusor interactions.

PLoS One 2018 7;13(3):e0193923. Epub 2018 Mar 7.

Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.

Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal bladder tissue. This study aimed to investigate the acute impact of ionizing radiation on the contractility of bladder strips and identify the radiation-sensitivity of the mucosa vs the detrusor. Guinea-pig bladder strips (intact or mucosa-free) received ex vivo sham or 20Gy irradiation and were studied with in vitro myography, electrical field stimulation and Ca2+-fluorescence imaging. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193923PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841802PMC
July 2018
4 Reads

6,7,4'-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice.

Eur J Pharmacol 2018 May 3;826:140-147. Epub 2018 Mar 3.

Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:

Daidzein is one of the major isoflavfones found in soy food and plants. Following ingestion, daidzein is readily converted to hydroxylated metabolites in the human body. 6,7,4'-Trihydroxyisoflavone (THIF), one of the metabolites of daidzein, has several pharmacological activities, including anti-cancer and anti-obesity properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2018.02.048DOI Listing
May 2018
7 Reads

The Red Alga Gracilariopsis chorda and Its Active Constituent Arachidonic Acid Promote Spine Dynamics via Dendritic Filopodia and Potentiate Functional Synaptic Plasticity in Hippocampal Neurons.

J Med Food 2018 May 2;21(5):481-488. Epub 2018 Mar 2.

1 Department of Biotechnology, Pukyong National University , Busan, Korea.

Exogenous neurotrophins can induce neuronal differentiation, outgrowth, survival, and synaptic function in the central nervous system. In primary cultures of rat hippocampal neurons, an ethanol extract of the red alga Gracilariopsis chorda (GCE) and its active compound arachidonic acid (AA) significantly increased the densities of dendritic filopodia and spines, promoted the expression of presynaptic vesicle protein 2 (SV2) and postsynaptic density protein 95 (PSD-95), induced robust synaptogenesis, and increased the expression of cell division control protein 42 (CDC42) and actin-related protein 2 (ARP2), which are important for actin organization in dendritic protrusions, and facilitated presynaptic plasticity by increasing the size of the synaptic vesicle pool at presynaptic nerve terminals. In addition, oral administration of GCE and AA for 10 days, at concentrations of 1 mg/g and 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jmf.2017.4026DOI Listing
May 2018
7 Reads

Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors.

Sci China Life Sci 2018 06 2;61(6):688-695. Epub 2018 Feb 2.

Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

The study of α4β2 nicotinic receptors has provided new indications in the treatment of pain. Efforts have been made to explore new α4β2 nicotinic receptor agonists, including TC-2559, as antinociceptive drugs. In this study, we discovered a set of novel epibatidine analogs with strong binding affinities to the α4β2 nicotinic receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11427-017-9062-3DOI Listing
June 2018
1 Read
1.690 Impact Factor

Dietary Supplementation of Almond Prevents Oxidative Stress by Advocating Antioxidants and Attenuates Impaired Aversive Memory in Male Rats.

Plant Foods Hum Nutr 2018 Mar;73(1):7-12

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.

Scopolamine, an anti-muscarinic agent, has been shown to induce amnesia and oxidative stress similar to that observed in the older age. The present study was designed to determine the relationship between the oxidative status and memory improvement in scopolamine injected rats pre-administered with almonds. Rats (n = 8) in the almond group were administered orally with 400 mg/kg almond suspension for 28 days daily before the intraperitoneal injection of scopolamine (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11130-018-0655-4DOI Listing
March 2018
3 Reads

Monosodium glutamate impairs the contraction of uterine visceral smooth muscle ex vivo of rat through augmentation of acetylcholine and nitric oxide signaling pathways.

Reprod Biol 2018 Mar 3;18(1):83-93. Epub 2018 Feb 3.

Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal 741235, India. Electronic address:

The aim of the study was to examine the toxic effects of Monosodium glutamate (MSG), an extensively used food additive, on the contraction of uterine visceral smooth muscle (UVSM) in rat and to elucidate the probable neurocrine mechanism involved in it. MSG produced significant potentiation of the force and inhibition of frequency of uterus recorded ex vivo in chronic MSG exposure and in single dose acute experiments. MSG also produced significant potentiation of force of acetylcholine induced contraction and no alterations in atropine induced contraction of uterus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.repbio.2018.01.006DOI Listing
March 2018
5 Reads

Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of Acetylcholinesterase.

Int J Mol Sci 2018 Jan 25;19(2). Epub 2018 Jan 25.

Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Korea.

Though Herba (ODH) has been known to exhibit anti-cancer and anti-inflammatory effects, its anti-amnestic effect has never been reported so far. The aim of this present study was to elucidate the anti-amnestic effect of ODH. ODH pretreatment significantly reduced escape latency of scopolamine treated Institute of Cancer Research (ICR) mice compared to untreated control groups in a Morris water maze test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19020363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855585PMC
January 2018
6 Reads

Antimuscarinic-induced convulsions in fasted mice after food intake: No evidence of spontaneous seizures, behavioral changes or neuronal damage.

Acta Neurobiol Exp (Wars) 2017 ;77(4):373-381

Department of Physiology, Faculty of Medicine, Istanbul Yeni Yuzyil University, Istanbul, Turkey.

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety‑related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these convulsions, mice treated i. Read More

View Article

Download full-text PDF

Source
August 2018
4 Reads

Soybean-Derived Phytoalexins Improve Cognitive Function through Activation of Nrf2/HO-1 Signaling Pathway.

Int J Mol Sci 2018 Jan 16;19(1). Epub 2018 Jan 16.

School of Food Science and Biotechnology (BK21plus Program), Kyungpook National University, Daegu 41566, Korea.

As soy-derived glyceollins are known to induce antioxidant enzymes in various types of cells and tissues, we hypothesized that the compounds could protect neurons from damage due to reactive oxygen species (ROS). In order to examine the neuroprotective effect of glyceollins, primary cortical neurons collected from mice and mouse hippocampal HT22 cells were challenged with glutamate. Glyceollins attenuated glutamate-induced cytotoxicity in primary cortical neuron isolated from mice carrying wild-type nuclear factor (erythroid-derived 2)-like 2 (Nrf2), but the compounds were ineffective in those isolated from Nrf2 knockout mice, suggesting the involvement of the Nrf2 signaling pathway in glyceollin-mediated neuroprotection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19010268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796214PMC
January 2018
29 Reads

Vanillin improves scopolamine‑induced memory impairment through restoration of ID1 expression in the mouse hippocampus.

Mol Med Rep 2018 Mar 9;17(3):4399-4405. Epub 2018 Jan 9.

Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea.

4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine‑induced alterations in cognition and the expression of DNA binding protein inhibitor ID‑1 (ID1), one of the inhibitors of DNA binding/differentiation proteins that regulate gene transcription, in the mouse hippocampus. Mice were treated with 1 mg/kg scopolamine with or without 40 mg/kg vanillin once daily for 4 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2018.8401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802214PMC
March 2018
16 Reads

Profound Prolonged Bradycardia and Hypotension after Interscalene Brachial Plexus Block with Bupivacaine.

J Emerg Med 2018 03 30;54(3):e41-e43. Epub 2017 Dec 30.

Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York.

Background: Interscalene brachial plexus blocks have been a routinely performed method of anesthesia for shoulder surgery that decreases the need for general anesthesia, length of stay, and recovery time. We describe a case of bupivacaine toxicity after an interscalene block.

Case Report: The patient was a 66-year-old man who presented to our Emergency Department by emergency medical services from an ambulatory surgery center where he had undergone rotator cuff surgery, with bradycardia and hypotension. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07364679173117
Publisher Site
http://dx.doi.org/10.1016/j.jemermed.2017.12.004DOI Listing
March 2018
14 Reads

Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy.

Chem Biol Interact 2018 Feb 19;281:69-80. Epub 2017 Dec 19.

Human and Environmental Toxicology, Department of Biology, University of Konstanz, Germany; Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Germany. Electronic address:

Propiverine, a frequently-prescribed pharmaceutical for the treatment of symptoms associated with overactive bladder syndrome, provoked massive intranuclear and cytosolic protein inclusions in rat proximal tubule epithelium, primarily consisting of the peroxisomal targeting signal 1 (PTS1) containing protein d-amino acid oxidase (DAAO). As this type of nephropathy was also observed for other drugs, the aim was to determine whether propiverine interferes with trafficking and/or import of peroxisomal proteins. To elucidate this, DAAO- and propiverine-specific interaction partners from human HEK293 and rat WKPT cell lines and rat kidney and liver homogenate were determined using co-immunoprecipitation with subsequent nano-ESI-LC-MS/MS analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2017.12.023DOI Listing
February 2018
8 Reads

Neuroprotective effect of Cubebin: A dibenzylbutyrolactone lignan on scopolamine-induced amnesia in mice.

Indian J Med Res 2017 Aug;146(2):255-259

Pharmacology Research Laboratory-II, Department of Pharmaceutical Sciences & Technology, Institute of Chemical TechnologyFNx01, Mumbai, India.

Background & Objectives: Acetylcholinesterase (AChE) inhibitors represent a major class of drugs which provide symptomatic relief and improvement in cognitive function in Alzheimer's disease (AD). In this study, cubebin, a dibenzylbutyrolactone lignan, was isolated from Piper cubeba and investigated for its AChE inhibitory activity in an attempt to explore its potential for memory-enhancing activities in mice.

Methods: Molecular docking of cubebin was carried out followed by in vitro AChE activity. Read More

View Article

Download full-text PDF

Source
http://www.ijmr.org.in/text.asp?2017/146/2/255/221089
Publisher Site
http://dx.doi.org/10.4103/ijmr.IJMR_156_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761036PMC
August 2017
9 Reads

Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model.

J Agric Food Chem 2018 Jan 20;66(1):99-107. Epub 2017 Dec 20.

Research Institute of Inflammatory Diseases, Kunkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.

The present study aimed to evaluate the preventive effects of highbush blueberry (Vaccinium corymbosum L.) vinegar (BV) on cognitive functions in a scopolamine (Sco)-induced amnesia model in mice. In this study, Sco (1 mg/kg, intraperitoneal injection) was used to induce amnesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.7b03965DOI Listing
January 2018
9 Reads

Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.

Toxicol Lett 2018 Sep 14;293:149-156. Epub 2017 Dec 14.

Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Accordingly, the mainstay pharmacotherapy against poisoning by OP comprises the competitive muscarinic acetylcholine receptor antagonist atropine to treat muscarinic effects and, in addition, oximes to reactivate inhibited AChE. A therapeutic gap still remains in the treatment of desensitized nicotinic acetylcholine receptors following OP exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2017.12.005DOI Listing
September 2018
19 Reads

[Claude Bernard and nicotinic receptors: from the neuromuscular junction to tobacco weaning].

Biol Aujourdhui 2017 13;211(2):169-172. Epub 2017 Dec 13.

Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Fédération de Médecine Translationnelle, Université et CHU de Strasbourg, 11 rue Humann, 67085 Strasbourg, France.

Claude Bernard (1813-1878) was fascinated by the pharmacological mechanisms of poisons. In particular, using a huge amount of ingenious and robust experiments, he demonstrated the peripheral toxic action of the natural compound curare. His work generated controversies in a period where scientific methodology and technical development followed the progression of concepts and ideas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017024DOI Listing
October 2018

Revalidation of the neuroprotective effects of a United States patented polyherbal formulation on scopolamine induced learning and memory impairment in rats.

Biomed Pharmacother 2018 Jan 9;97:1046-1052. Epub 2017 Nov 9.

Collaborative Programme, Institute of Medical Science, BHU, Varanasi, India; Department of Kriya Sharir, Faculty of Ayurveda, IMS, BHU, Varanasi, India. Electronic address:

Objective: Alzheimer's disease (AD) is the most common cause of dementia yet treatment options are extremely limited. The disease is associated with cognitive impairment as well as structural irregularities, accumulation of plaques and neurofibrillary tangles, diminished levels of acetylcholine, oxidative stress, and inflammation in the brain. We have previously reported on the positive effects of a united states patented (US 7,273,626 B2) poly herbal test formulation, consisting of Bacopa monnieri, Hippophae rhamnoides and Dioscorea bulbifera extracts, on cognitive deficits in AD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2017.11.008DOI Listing
January 2018
3 Reads

20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.

Chem Biol Interact 2018 Jan 10;279:64-72. Epub 2017 Nov 10.

Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Hunan Laboratory Animal Center, Hunan Provincial Research Center for Safety Evaluation of Drugs, Changsha, China. Electronic address:

20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects and exhibited strong antidepressant-like effects in vivo. The objective of the present study was first to investigate the effect of PPD in scopolamine (SCOP)-induced memory deficit in mice and the potential mechanisms involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2017.11.008DOI Listing
January 2018
19 Reads

Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques.

Toxicol Lett 2018 Sep 9;293:229-234. Epub 2017 Nov 9.

Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, La Jolla 92093-0650, United States. Electronic address:

Fatalities from organophosphate (OP) insecticide result from both occupational and deliberate exposure; significantly impacting human health. Like nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterases (AChE) in central and peripheral synapses in the cholinergic nervous system. Post-exposure therapeutic countermeasures generally include administration of atropine with a pyridinium aldoxime e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2017.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943181PMC
September 2018
12 Reads

Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point.

Toxicol Lett 2018 Sep 7;293:167-171. Epub 2017 Nov 7.

Toxicology, Trauma and Medicine Group, CBR Division, Defence Science and Technology Laboratory Porton Down, SP4 0JQ, UK.

Medical countermeasures for acute poisoning by organophosphorus nerve agents are generally assessed over 24h following poisoning and a single administration of treatment. At 24h, the antinicotinic bispyridinium compound MB327 (1,10-(propane-1,3-diyl)bis(4-tert-butylpyridinium)) dimethanesulfonate is as effective as the oxime HI-6 against poisoning by soman, when used as part of a treatment containing atropine and avizafone. In this study, we hypothesised that an earlier endpoint, at 6h, would be more appropriate for the pharmacokinetics and mechanism of action of MB327 and would therefore result in improved protection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2017.11.006DOI Listing
September 2018
5 Reads

Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug.

Toxicol Lett 2018 Sep 7;293:77-81. Epub 2017 Nov 7.

New York Medical College, Valhalla, NY, United States.

Sulfur mustard (SM, bis(2-chloroethyl sulfide) is a potent vesicating agent known to cause skin inflammation, necrosis and blistering. Evidence suggests that inflammatory cells and mediators that they generate are important in the pathogenic responses to SM. In the present studies we investigated the role of mast cells in SM-induced skin injury using a murine vapor cup exposure model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938161PMC
September 2018
13 Reads

Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.

Basic Clin Pharmacol Toxicol 2018 Apr 5;122(4):429-435. Epub 2017 Dec 5.

Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, UK.

The influence of three newly developed bispyridinium antinicotinic compounds (the non-oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non-oximes was evaluated by determination of the LD values of the nerve agents and measurement of the survival time after supralethal poisoning. Addition of all the tested non-oximes increased significantly the therapeutic efficacy of atropine in combination with an oxime against tabun poisoning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcpt.12935DOI Listing
April 2018
7 Reads

Anticholinergic toxicity in a one-year-old male following ingestion of Lupinus mutabilis seeds: case report.

Sao Paulo Med J 2017 Nov 6. Epub 2017 Nov 6.

MD. Professor, School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru and Attending Physician, Pediatric Intensive Care Service, Hospital de Emergencias Pediátricas, Lima, Peru.

Context: The seeds from Lupinus mutabilis Sweet, also called "chocho", are an important part of the diet in several countries in South America. Prior to consumption, processing is required to remove toxic alkaloids. These alkaloids are known to have pharmacological properties as antiarrhythmics, antimuscarinics and hypoglycemics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1516-3180.2016.0157220517DOI Listing
November 2017
10 Reads

Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.

Epilepsy Res 2017 12 29;138:88-97. Epub 2017 Oct 29.

Departament of Physiology, Universidade Federal de São Paulo, São Paulo, SP 04039-032, Brazil. Electronic address:

Brain injuries are often associated with the later development of epilepsy. Evidence suggests that morphological and functional changes occur in the remaining neural tissue during a silent (or latent) period in which no seizures are expressed. It is believed that this silent (reorganization) period may provide a therapeutic window for modifying the natural history of disease progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2017.10.019DOI Listing
December 2017
14 Reads