4,661 results match your criteria Toxicity Amphetamine

Silencing the Gene Alleviates Methamphetamine-Induced Hepatotoxicity by Inhibiting Lipopolysaccharide-Mediated Inflammation in Mice.

Int J Mol Sci 2022 Jun 18;23(12). Epub 2022 Jun 18.

Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, No. 1838 North Guangzhou Road, Guangzhou 510515, China.

Methamphetamine (METH) is a stimulant drug. METH abuse induces hepatotoxicity, although the mechanisms are not well understood. METH-induced hepatotoxicity was regulated by TLR4-mediated inflammation in BALB/c mice in our previous study. Read More

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Effect of leaching time on phytotoxicity of dissolved organic matter derived from black carbon based on spectroscopy.

Environ Pollut 2022 Aug 7;307:119595. Epub 2022 Jun 7.

College of Agriculture, Northeast Agricultural University, Harbin 150030, China.

Black carbon (BC) exports huge amounts of its derived DOM from terrestrial ecosystems annually through a variety of ways (i.e., erosion or runoff migration). Read More

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A review on the mitochondrial toxicity of "ecstasy" (3,4-methylenedioxymethamphetamine, MDMA).

Curr Res Toxicol 2022 19;3:100075. Epub 2022 May 19.

UCIBIO, Applied Molecular Biosciences Unit, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a drug of abuse used by millions worldwide. MDMA human abuse and dependence is well described, but addictive properties are not always consistent among studies. This amphetamine is a substrate type releaser, binding to monoamine transporters, leading to a pronounced release of serotonin and noradrenaline and to a minor extent dopamine. Read More

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Implications of speciation on rare earth element toxicity: A focus on organic matter influence in Daphnia magna standard test.

Environ Pollut 2022 Aug 28;307:119554. Epub 2022 May 28.

Université de Lorraine, CNRS, LIEC, F-57000, Metz, France; LTSER-Zone Atelier Moselle, F-57000, Metz, France.

Rare earth elements (REE) have become essential in high- and green-technologies. Their increasing use lead to the release of anthropogenic REE into the environment including aquatic systems. The limited data available on the aquatic ecotoxicology of REE indicate their biological effects are highly dependent on their speciation, posing challenges for a reliable environmental risk assessment (ERA). Read More

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Targeting A and p-Tau Clearance in Methamphetamine-Induced Alzheimer's Disease-Like Pathology: Roles of Syntaxin 17 in Autophagic Degradation in Primary Hippocampal Neurons.

Oxid Med Cell Longev 2022 18;2022:3344569. Epub 2022 May 18.

Key Lab of Modern Toxicology (NJMU), Ministry of Education; Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, Jiangsu 211166, China.

Methamphetamine (Meth), a central nervous system (CNS) stimulant with strong neurotoxicity, causes progressive cognitive impairment with characterized neurodegenerative changes. However, the mechanism underlying Meth-induced pathological changes remains poorly understood. In the current study, Meth elicited a striking accumulation of the pathological proteins hyperphosphorylated tau (p-tau) and amyloid beta (A) in primary hippocampal neurons, while the activation of autophagy dramatically ameliorated the high levels of these pathological proteins. Read More

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Reverse Takotsubo Cardiomyopathy After Accidental Exposure to an Illicit Substance: A Case Report.

Cureus 2022 Apr 19;14(4):e24282. Epub 2022 Apr 19.

Emergency Medicine, St. Luke's University Health Network, Bethlehem, USA.

Stress-induced (Takotsubo) cardiomyopathy is a clinical syndrome and its incidence has been on the rise. Patients with this syndrome often present with chest pain, dyspnea, or syncope. The findings from a typical cardiac evaluation can make this entity difficult to distinguish from acute myocardial infarction (AMI). Read More

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Treatment of Malignant Hyperthermia During Interfacility Transport of a Patient With Methamphetamine Toxicity.

Air Med J 2022 May-Jun;41(3):320-322. Epub 2022 Feb 15.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.

Malignant hyperthermia (MH) is a rare disorder that leads to a hypermetabolic response; if unrecognized, it can quickly lead to serious morbidity and mortality. It is imperative that critical care transport providers are able to recognize and initiate treatment for MH. A 33-year-old man presented to the emergency department with seizures and altered mental status after ingesting methamphetamine. Read More

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Identifying behaviours for survival and wellness among people who use methamphetamine with opioids in British Columbia: a qualitative study.

Harm Reduct J 2022 May 19;19(1):46. Epub 2022 May 19.

BC Centre for Disease Control, 655 W 12th Ave, Vancouver, BC, V5Z 4R4, Canada.

Background: British Columbia (BC) has been in a state of public health emergency since 2016, due to the unprecedented numbers of fatal and non-fatal drug toxicity (i.e. overdose) events. Read More

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Possible Delay in Symptomatology of a Methadone Overdose in a Patient Ingesting an Energy Drink and Dextroamphetamine/Amphetamine.

J Pharm Pract 2022 May 6:8971900221100812. Epub 2022 May 6.

Department of Emergency Medicine, 2345Medical University of South Carolina, Charleston, SC, USA.

Methadone is a mu-opioid agonist with a delayed time to peak concentration that requires an extended period of monitoring following an overdose. Available data suggests that the combination of psychostimulants with methadone may augment antinociception and tolerance to opioids. A 26-year-old male (83. Read More

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Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress.

Oxid Med Cell Longev 2022 18;2022:4445734. Epub 2022 Apr 18.

School of Health and Physical Education, Jianghan University, Wuhan 430056, China.

Methamphetamine can cause oxidative stress-centered lipid peroxidation, endoplasmic reticulum stress, mitochondrial dysfunction, excitatory neurotoxicity, and neuroinflammation and ultimately lead to nerve cell apoptosis, abnormal glial cell activation, and dysfunction of blood-brain barrier. Protecting nerve cells from oxidative destroy is a hopeful strategy for treating METH use disorder. Nrf2 is a major transcriptional regulator that activates the antioxidant, anti-inflammatory, and cell-protective gene expression through endogenous pathways that maintains cell REDOX homeostasis and is conducive to the survival of neurons. Read More

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Nano-bio interfacial interactions determined the contact toxicity of nTiO to nematodes in various soils.

Sci Total Environ 2022 Aug 22;835:155456. Epub 2022 Apr 22.

Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Department of Environmental Science, Zhejiang University, Hangzhou 310058, China; Zhejiang Ecological Civilization Academy, Anji 313300, China. Electronic address:

The biological effect of soilborne nanoparticles (NPs) is a manifestation of soil-NMs-bio interactions. Soil factors are known to restructure NPs surfaces and thus influence the nanotoxicity. However, the mechanisms by which environmental factors affecting nano-bio interactions to aggravate or alleviate nanotoxicities are poorly understood. Read More

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Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders.

Molecules 2022 Apr 14;27(8). Epub 2022 Apr 14.

Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

The word "psychedelic" (psyche (i.e., the mind or soul) and delos (i. Read More

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Comparison of clinical characteristics between meth/amphetamine and synthetic cathinone users presented to the emergency department.

Clin Toxicol (Phila) 2022 Apr 19:1-7. Epub 2022 Apr 19.

Department of Emergency Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

Background: Synthetic cathinones (SC) are popular new psychoactive substances that produce sympathomimetic toxicity. Meth/amphetamine and SC have similar chemical structures and pharmacological effects. We aimed to compare the clinical characteristics between meth/amphetamine and SC users presenting to the emergency department (ED). Read More

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Role of the cannabinoid CB1 receptor in methamphetamine-induced social and recognition memory impairment.

Neurosci Lett 2022 05 14;779:136634. Epub 2022 Apr 14.

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Methamphetamine (METH) has been reported to induce social and recognition memory impairment. Evidence suggests that the cannabinoid system has an important modulatory role in cognitive processing and social interaction. Nonetheless, no previous study has investigated the probable role of the cannabinoids system on METH-induced deficits of novel object recognition (NOR) memory and social interaction. Read More

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Amphetamine toxicity masked by concomitant γ-hydroxybutyrate (GHB) ingestion.

Am J Emerg Med 2022 Mar 31. Epub 2022 Mar 31.

Department of Critical Care Medicine, Taipei Medical University Hospital, Taipei City, Taiwan; Department of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei City, Taiwan. Electronic address:

We report a case of a young male with amphetamine toxicity initially obscured by concomitant use of gamma-hydroxybutyrate (GHB), and the sympathomimetic symptoms emerged after GHB's effects receded. A 24-year-old unconscious man presented to emergency department showed the following vital signs upon admission: blood pressure 136/58 mmHg; heart rate 79 bpm; SpO2 87% under ambient air; body temperature 36.1 °C; Glasgow Coma Scale score 3. Read More

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Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage.

J Neural Transm (Vienna) 2022 Jun 14;129(5-6):703-711. Epub 2022 Apr 14.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Lenggstrasse 31, CH-8032, Zurich, Switzerland.

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") use has been linked to persistent alterations of the brain serotonergic (5-HT) system in animal and human studies, but the molecular underpinnings are still unclear. Cytoskeletal structures such as neurofilament light chain (NfL) are promising markers of drug-induced brain toxicity and may be involved in MDMA neurotoxicity. The brain-derived neurotrophic factor (BDNF) promotes the growth and sprouting of 5-HT neurons and its differential response to MDMA administration was suggested to mediate dose- and region-dependent 5-HT damage by MDMA. Read More

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Terminalia chebula extracts ameliorate methamphetamine-induced memory deficits via activating the ERK and Nrf2 pathway.

Brain Res Bull 2022 06 8;184:76-87. Epub 2022 Apr 8.

Wuhan Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China. Electronic address:

As a psychoactive substance abused worldwide, methamphetamine (METH) abuse leads to multiple neurodegenerative symptoms including memory deficits. Terminalia chebula retzius extracts (TREs) isolated by our lab have great antioxidant activity and its effect on METH-induced memory deficits has not been investigated yet. The present study was designed to investigate the protective effect of TREs on METH induced cell apoptosis in vitro and memory deficits in vivo. Read More

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Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice.

Toxicol Appl Pharmacol 2022 May 4;443:116011. Epub 2022 Apr 4.

Department of Toxicology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No. 1838 North Guangzhou Road, 510515 Guangzhou, China. Electronic address:

Methamphetamine (METH) is a psychostimulant abused worldwide. Its abuse induces intestinal toxicity. Moreover, the gut microbiota is altered by drugs, which induces intestinal injury. Read More

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Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.

Oxid Med Cell Longev 2022 28;2022:8400876. Epub 2022 Mar 28.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.

Chronic and long-term methamphetamine (METH) abuse is bound to cause damages to multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS), a type of flavonoid and one of the main active ingredients of the traditional Chinese medicine , exhibits a variety of biological and pharmacological properties such as anti-inflammatory, antioxidant, and anticancer activities. However, whether ICS could protect against METH-induced neurotoxicity remains unknown. Read More

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ClO pre-oxidation changes dissolved organic matter at the molecular level and reduces chloro-organic byproducts and toxicity of water treated by the UV/chlorine process.

Water Res 2022 Jun 21;216:118341. Epub 2022 Mar 21.

School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

The formation of undesirable chloro-organic byproducts is of great concern in the UV/chlorine process. In this study, chlorine dioxide (ClO) pre-oxidation was applied to control the formation of chloro-organic byproducts and the toxicity in UV/chlorine-treated water. The molecular-level changes in dissolved organic matter (DOM) were tracked by using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) and ClO pre-oxidation was found to preferentially react with DOM moieties with high aromaticity level and with a carbon number of > 18, producing compounds with a higher degree of oxidation and lower aromaticity. Read More

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Dissolved organic matter heightens the toxicity of tetrabromobisphenol A to aquatic organisms.

Ecotoxicology 2022 Jul 31;31(5):725-734. Epub 2022 Mar 31.

College of Environmental Sciences and Engineering, Dalian Maritime University, 116026, Dalian, China.

Tetrabromobisphenol A (TBBPA) is a new type of persistent organic pollutant, which causes environmental pollution and health problems, and has attracted the attention of the international research community. Once released into the environment, TBBPA can interact with dissolved organic matter (DOM), which affects its behavior. However, the effect of DOM on the biological toxicity of TBBPA remains unclear. Read More

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Neuroligin-1 plays an important role in methamphetamine-induced hippocampal synaptic plasticity.

Toxicol Lett 2022 May 22;361:1-9. Epub 2022 Mar 22.

School of Forensic Medicine, Wannan Medical College, NO. 22 West Wen Chang Rd, Wuhu 241000, People's Republic of China. Electronic address:

The neurotoxic effects of methamphetamine (METH) include not only neuronal apoptosis and autophagy, but also lead to substance use disorder and have become increasingly prominent. Studies suggest that synaptic plasticity may be the structural basis of METH-induced neurological impairment. Neuroligins are postsynaptic adhesion molecules involved in the regulation of synaptic organization and function. Read More

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Blueberry juice augments exercise-induced neuroprotection in a Parkinson's disease model through modulation of GDNF levels.

IBRO Neurosci Rep 2022 Jun 7;12:217-227. Epub 2022 Mar 7.

Pittsburgh Institute of Neurodegenerative Disease, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Exercise and consumption of plant-based foods rich in polyphenols are attractive therapeutic approaches for the prevention and treatment of Parkinson's disease (PD). Few studies, however, have examined the neuroprotective efficacy of combining these treatment modalities against PD. Therefore we investigated whether combining voluntary running and consumption of blueberry juice (BBJ) was more efficacious against 6-hydroxydopamine (6-OHDA) toxicity than either treatment alone. Read More

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Implication of thyroid hormone receptors in methamphetamine neurocognitive effects.

Neurotoxicology 2022 May 15;90:130-135. Epub 2022 Mar 15.

NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Methamphetamine (MA) induces neurocognitive effects via several mechanisms. In the present study, we investigated the alteration of thyroid hormone receptor's expression in the context of MA-induced memory impairment and explored the protective effects of exogenous thyroid hormones (THs). Male wistar rats, received increasing regimen of MA (1-10 mg/kg, intraperitoneal, twice a day for 10 days), were treated with T3 (40 μg/rat/day; intranasal, 2. Read More

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Characterization of mercury binding to different molecular weight fractions of dissolved organic matter.

J Hazard Mater 2022 06 2;431:128593. Epub 2022 Mar 2.

College of Life Science, Northeast Agricultural University, Heilongjiang 150030, China. Electronic address:

Dissolved organic matter (DOM) can strongly complex with various contaminants. Therefore, DOM was deemed as an environmentally friendly substance for controlling the mobility, bioavailability, speciation, toxicity, and fate of metal contaminants in environment. In this study, composting-derived DOM was categorized into three fractions based on different molecular weights (MWs). Read More

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Lagrangian profiles of riverine autotrophy, organic matter transformation, and micropollutants at extreme drought.

Sci Total Environ 2022 Jul 1;828:154243. Epub 2022 Mar 1.

Helmholtz Centre for Environmental Research - UFZ, Department of River Ecology, Brückstraße 3a, D-39114 Magdeburg, Germany.

On their way from inland to the ocean, flowing water bodies, their constituents and their biotic communities are exposed to complex transport and transformation processes. However, detailed process knowledge as revealed by Lagrangian measurements adjusted to travel time is rare in large rivers, in particular at hydrological extremes. To fill this gap, we investigated autotrophic processes, heterotrophic carbon utilization, and micropollutant concentrations applying a Lagrangian sampling design in a 600 km section of the River Elbe (Germany) at historically low discharge. Read More

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Research Progress on the Omics of Methamphetamine Toxic Damage and Addiction.

Fa Yi Xue Za Zhi 2021 Dec;37(6):776-787

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China.

The mechanism of methamphetamine toxicity and addiction is the key research direction of forensic toxicology, and the development of omics technology provides a new platform for further study of this direction. METH toxic damage and addiction are reflected differently in genes, ribonucleic acid (RNA) transcription, protein and metabolism. This article summarizes the achievements and shortcomings of multi-omics technologies such as genome, transcriptome, metabolome and proteome in the study of METH damage and addiction, and discusses the strategies and advantages of multi-omics combined analysis in the study of METH toxic damage and addiction mechanism, in order to provide more useful reference information for forensic toxicology of METH. Read More

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December 2021

Current Situation of Methamphetamine Abuse and Related Research Progress.

Fa Yi Xue Za Zhi 2021 Dec;37(6):763-775

School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.

Drug problem is a major social and public security problem in the world. Drug abuse poses a great threat to economic development, social stability and public health. In recent years, synthetic drugs represented by methamphetamine have surpassed traditional drugs such as morphine, heroin, ketamine and become one of the most abused drugs in the world. Read More

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December 2021

The characteristics of dissolved organic matter release from UV-aged microplastics and its cytotoxicity on human colonic adenocarcinoma cells.

Sci Total Environ 2022 Jun 26;826:154177. Epub 2022 Feb 26.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China; Key Laboratory of Plant Nutrition and the Agro-environment in Northwest China, Ministry of Agriculture, Yangling, Shaanxi 712100, China. Electronic address:

There are a large number of microplastic (MPs) in the sea or on land, most of which undergo physical, chemical or biological processes leading to the release of dissolved organic matter (DOM). In this study, we analyzed the change of Polyurethane microplastic (PU-MPs) valence bond under different aging conditions thanks to Fourier transform infrared spectroscopy (FTIR) and its surface characteristics using scanning electron microscopy (SEM) and also described the characteristics of DOM dissolved from PU (PU-DOM) under UV aging process in two different medium (water and air), based on Dissolved organic carbon (DOC) measurements, UV-visible spectrometer and Three-dimensional excitation emission matrices (3D-EEMs). The DOC data both showed that Under UV aging of different systems, PU-DOM concentration increases with the extension of aging time, and correspondingly, its toxicity to human colon adenocarcinoma cells also increases, but the release amount of PU-DOM under air aging is higher than that of PU-DOM in water. Read More

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Photodegradation of propranolol in surface waters: An important role of carbonate radical and enhancing toxicity phenomenon.

Chemosphere 2022 Jun 25;297:134106. Epub 2022 Feb 25.

School of Water Resources and Hydropower Engineering, North China Electric Power University, Beijing, 102206, China.

Antihypertensive propranolol (PRO) is frequently detected in surface waters and has adverse effects on aquatic organisms. In this study, its photochemical fate in surface water with the aspect of kinetics, products and toxicity were investigated employing steady-state photochemistry experiments and ecotoxicity tests. The results showed that photodegradation of PRO was enhanced in river water than that in phosphate buffer where dissolved organic matter (DOM), NO, and HCO played important roles. Read More

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