4,177 results match your criteria Toxicity Amphetamine


Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance.

J Pharmacol Exp Ther 2018 Nov 9. Epub 2018 Nov 9.

Centre for Applied Pharmacokinetic Research, University of Manchester

In vitro-in vivo extrapolation (IVIVE) of renal excretory clearance (CLR) using the physiologically-based kidney models can provide mechanistic insight into the interplay of multiple processes occurring in the renal tubule. However, the ability of these models to quantitatively capture the impact of perturbed conditions (e.g. Read More

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.251413DOI Listing
November 2018
5 Reads

HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling.

Toxicol Lett 2018 Dec 24;299:159-171. Epub 2018 Sep 24.

CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address:

Methamphetamine (Meth) is an addictive psychostimulant whose abuse is intimately linked to increased risks for HIV-1 infection. Converging lines of evidence indicate that Meth also aggravates the symptoms of HIV-associated neurocognitive disorders (HAND), though the underlying mechanisms remain poorly understood. By using the lipophilic antioxidant N-acetylcysteine amide (NACA) as an interventional agent, we examined the roles of oxidative stress in autophagy and apoptosis induced by HIV-Tat (the transactivator of transcription), Meth or their combined treatment in human SH-SY5Y neuroblastoma cells and in the rat striatum. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.09.009DOI Listing
December 2018
14 Reads
3.260 Impact Factor

ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.

J Neuroinflammation 2018 Aug 31;15(1):246. Epub 2018 Aug 31.

Department of Physiology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410007, People's Republic of China.

Background: Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, the direct relevance between airway inflammation and BD-like psychiatric comorbidity is almost unknown. Integrin β4 (ITGB4) is downregulated on the airway epithelial of asthma patients, which might play a critical role in the parthenogenesis of airway inflammation. Read More

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http://dx.doi.org/10.1186/s12974-018-1283-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117971PMC
August 2018
2 Reads

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress.

Oxid Med Cell Longev 2018 22;2018:4982453. Epub 2018 Jul 22.

Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Pisa, Italy.

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field of drug abuse since it allows getting an insight into the molecular mechanisms which operate in a variety of neuropsychiatric disorders. In fact, key alterations produced by methamphetamine involve dopamine neurotransmission in a way, which is reminiscent of spontaneous neurodegeneration and psychiatric schizophrenia. Read More

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http://dx.doi.org/10.1155/2018/4982453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081569PMC
October 2018
6 Reads

Khat: A Substance of Growing Abuse with Adverse Drug Interaction Risks.

Authors:
Worku Abebe

J Natl Med Assoc 2018 Dec 3;110(6):624-634. Epub 2018 May 3.

Department of Oral Biology/Pharmacology, Dental College of Georgia, Augusta University Augusta, GA 30912-1128, USA. Electronic address:

The growing global availability of the stimulant shrub, khat, has aroused widespread concern. This paper is a review of possible adverse interactions between khat and conventional drugs. Khat chewing has been shown to reduce the bioavailabilities of orally co-administered antibiotics, ampicillin, amoxicillin, cephradine and tetracyclineHCl, and the antimalarial drug, chloroquine. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00279684183006
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http://dx.doi.org/10.1016/j.jnma.2018.04.001DOI Listing
December 2018
11 Reads

Fatal Poisonings Associated with New Psychoactive Substances.

Handb Exp Pharmacol 2018 Aug 14. Epub 2018 Aug 14.

Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.

This chapter describes how new psychoactive substances (NPS) have been involved in fatal intoxications from 2010 and onwards. It summarizes the circumstances, antemortem symptoms, and adverse effects that have led to death after ingestion of one or more NPS and tabulates concentrations, and postmortem findings from these intoxications.Consumption of NPS exerts health problems and unknown risks for the users. Read More

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http://dx.doi.org/10.1007/164_2018_110DOI Listing
August 2018
4 Reads

Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011-2014).

Vet Med (Auckl) 2017 30;8:77-85. Epub 2017 Oct 30.

Emergency and Critical Care, Animal Specialty Group, Los Angeles, CA, USA,

The objective of this retrospective study was to describe the responses to treatment with intravenous lipid emulsion (ILE) and the outcomes for a variety of severe intoxications. This case series includes 10 client-owned animals, 9 dogs and 1 cat, that underwent treatment with ILE for a variety of severe intoxications over a 4-year period. History, physical examination findings, clinical signs, clinicopathological test results, treatment, response to treatment, and outcome were recorded. Read More

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http://dx.doi.org/10.2147/VMRR.S129576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042488PMC
October 2017
4 Reads

An Unusual Case of Hearing Loss.

J Emerg Med 2018 09 21;55(3):411-414. Epub 2018 Jul 21.

Department of Emergency Medicine, Harvard Medical School, Boston, Massachusetts; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jemermed.2018.06.005DOI Listing
September 2018
6 Reads

Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.

Cell Prolif 2018 Oct 28;51(5):e12476. Epub 2018 Jun 28.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Objectives: Methamphetamine (MA) abuse evokes pulmonary toxicity. The aim of our study is to investigate if autophagy is induced by MA and if autophagy-initiated apoptosis in alveolar epithelial cells is involved in MA-induced chronic pulmonary toxicity.

Materials And Methods: The rats in Control group and MA group were tested by Doppler and HE staining. Read More

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http://dx.doi.org/10.1111/cpr.12476DOI Listing
October 2018
10 Reads

A Case Study Involving U-47700, Diclazepam and Flubromazepam-Application of Retrospective Analysis of HRMS Data.

J Anal Toxicol 2018 Nov;42(9):655-660

Forensic Science SA (Toxicology), Adelaide, South Australia, Australia.

The number of new psychoactive substances (NPS) available is constantly increasing, making it difficult for toxicology laboratories to keep screening methods up to date. Full scan high-resolution mass spectrometry (HRMS) is a versatile technique which allows for progressive updating of spectral databases to increase the scope of screening. It also allows for retrospective screening of data-specifically, reprocessing of data files using an updated spectral database without the need for re-extraction or reanalysis. Read More

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http://dx.doi.org/10.1093/jat/bky039DOI Listing
November 2018
11 Reads

Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of -Hydroxymethamphetamine.

Drug Metab Dispos 2018 09 18;46(9):1277-1284. Epub 2018 Jun 18.

Departments of Pharmaceutics (D.J.W., L.M.S., D.D.S., J.W.) and Pharmacy (S.A.), University of Washington, Seattle, Washington

Methamphetamine is one of the most widely abused illicit drugs. Although human intoxication and multiple tissue toxicities frequently occur in abusers, little is known about the distribution of methamphetamine or its primary metabolites, amphetamine and -hydroxymethamphetamine (-OHMA), to their sites of toxicity. This study determined the pharmacokinetics, tissue exposure, and partition ratios of methamphetamine and major metabolites in various mouse tissues and investigated the impact of organic cation transporter 3 (Oct3) following i. Read More

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http://dmd.aspetjournals.org/lookup/doi/10.1124/dmd.118.0821
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http://dx.doi.org/10.1124/dmd.118.082131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081671PMC
September 2018
14 Reads

Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats.

Int J Pharm 2018 Sep 7;548(1):1-14. Epub 2018 Jun 7.

Department of Morphology, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil; Post-Graduation Programme in Structural and Functional Biology, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil; Post-Graduation Programme in Health Science, Federal University of Rio Grande do Norte, Natal 59072-970, RN, Brazil. Electronic address:

This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.06.008DOI Listing
September 2018
2 Reads

Autophagy plays a pro-survival role against methamphetamine-induced apoptosis in H9C2 cells.

Toxicol Lett 2018 Sep 12;294:156-165. Epub 2018 May 12.

Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, 818 Tian Yuan East Road, Nanjing, Jiangsu, 211166, China. Electronic address:

Methamphetamine (METH) is a commonly abused psychostimulant that can induce severe neurotoxicity. Cardiovascular injury caused by METH has recently gained increasing attention; however, the underlying mechanisms remain unclear. As autophagy has been shown to be associated with cell injury, the association between autophagy and METH-mediated cell apoptosis was investigated in the present study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183020
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http://dx.doi.org/10.1016/j.toxlet.2018.05.017DOI Listing
September 2018
9 Reads

Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat.

Front Psychiatry 2018 24;9:144. Epub 2018 Apr 24.

Department of Experimental Neurobiology, National Institute of Mental Health, Klecany, Czechia.

3,4-methylenedioxypyrovalerone (MDPV) is a potent pyrovalerone cathinone that is substituted for amphetamines by recreational users. We report a comprehensive and detailed description of the effects of subcutaneous MDPV (1-4 mg/kg) on pharmacokinetics, biodistribution and metabolism, acute effects on thermoregulation under isolated and aggregated conditions, locomotion (open field) and sensory gating (prepulse inhibition, PPI). All studies used male Wistar rats. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928397PMC
April 2018
6 Reads

DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants.

ACS Chem Neurosci 2018 Oct 11;9(10):2379-2394. Epub 2018 May 11.

Department of Psychology , Arizona State University , Tempe , Arizona 85281 , United States.

Cathinone is a plant alkaloid found in khat leaves of perennial shrubs grown in East Africa. Similar to cocaine, cathinone elicits psychostimulant effects which are in part attributed to its amphetamine-like structure. Around 2010, home laboratories began altering the parent structure of cathinone to synthesize derivatives with mechanisms of action, potencies, and pharmacokinetics permitting high abuse potential and toxicity. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197900PMC
October 2018
6 Reads

The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats.

Neurotox Res 2018 Oct 30;34(3):525-537. Epub 2018 Apr 30.

Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna, 31-343, Kraków, Poland.

According to the European Drug Report (2016), the use of synthetic cathinones, such as mephedrone, among young people has rapidly increased in the last years. Studies in humans indicate that psychostimulant drug use in adolescence increases risk of drug abuse in adulthood. Mephedrone by its interaction with transporters for dopamine (DAT) and serotonin (SERT) stimulates their release to the synaptic cleft. Read More

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http://dx.doi.org/10.1007/s12640-018-9908-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154178PMC
October 2018
5 Reads

Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice.

Behav Brain Res 2018 09 27;349:73-79. Epub 2018 Apr 27.

Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Mild neurocognitive impairments are common in people with human immunodeficiency virus (HIV) infection. HIV-encoded proteins, such as trans-activator of transcription (TAT), contribute to neuropathology and cognitive function in medicated subjects. The combination of TAT and comorbid methamphetamine use may further impair neurocognitive function in HIV-positive individuals by affecting dopaminergic systems in the brain. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.04.046DOI Listing
September 2018
2 Reads

CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway.

Toxicol Lett 2018 Aug 26;292:97-107. Epub 2018 Apr 26.

School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. Electronic address:

Overexposure to methamphetamine (METH) causes apoptosis in a number of cell types, particularly neuronal cells. However, the underlying mechanisms of METH-induced neuronal apoptosis remain to be elucidated. Accumulation of microtubule-associated protein Tau can lead to activation of multiple neurotoxic pathways, which is closely correlated with neuronal apoptosis. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.04.027DOI Listing
August 2018
26 Reads

Quantification of Methamphetamine «Shabu» in Biological Matrices to Detect Prenatal Exposure: A Case Report and a Literature Review.

Curr Pharm Biotechnol 2018 ;19(2):163-174

Drug Testing Consultants, #801 265 Russell Hill Road, Toronto, ON, M4V2T3, Canada.

Background: Methamphetamine misuse represents an increasing global public health problem. Its consumption during pregnancy becomes a relevant issue, since it has clinical consequences for the child's health and the pregnant woman. Despite this, there are only few data in the literature that include analytical results in the matrices used to detect prenatal exposure. Read More

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http://www.eurekaselect.com/161634/article
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http://dx.doi.org/10.2174/1389201019666180427111735DOI Listing
October 2018
7 Reads

Protective Effects of Ginsenoside Rb1 against Blood-Brain Barrier Damage Induced by Human Immunodeficiency Virus-1 Tat Protein and Methamphetamine in Sprague-Dawley Rats.

Am J Chin Med 2018 ;46(3):551-566

† School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, P. R. China.

Although antiretroviral therapy has helped to improve the lives of individuals infected with human immunodeficiency virus 1 (HIV-1), these patients are often still afflicted with HIV-1-associated neurocognitive disorders, which can lead to neurocognitive impairment and even dementia, and continue to hamper their quality of life. Methamphetamine abuse in HIV-1 patients poses a potential risk for HIV-associated neurocognitive disorders, because methamphetamine and HIV-1 proteins such as transactivator of transcription can synergistically damage the blood-brain barrier (BBB). In this study, we aimed to examine the effects of methamphetamine and HIV-1 Tat protein on the blood-brain barrier function and to determine whether ginsenoside Rb1 (GsRb1) plays a role in protecting the BBB. Read More

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http://dx.doi.org/10.1142/S0192415X18500283DOI Listing
July 2018
18 Reads

Exposure to Far Infrared Ray Protects Methamphetamine-Induced Behavioral Sensitization in Glutathione Peroxidase-1 Knockout Mice via Attenuating Mitochondrial Burdens and Dopamine D1 Receptor Activation.

Neurochem Res 2018 May 23;43(5):1118-1135. Epub 2018 Apr 23.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Evidence indicates that stress conditions might lead to drug dependence. Recently, we have demonstrated that exposure to far infrared ray (FIR) attenuates acute restraint stress via induction of glutathione peroxidase-1 (GPx-1) gene. We investigated whether FIR affects methamphetamine (MA)-induced behavioral sensitization and whether FIR-mediated pharmacological activity requires interaction between dopamine receptor and GPx-1 gene. Read More

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http://dx.doi.org/10.1007/s11064-018-2528-5DOI Listing
May 2018
2 Reads

Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances.

Handb Exp Pharmacol 2018 Apr 10. Epub 2018 Apr 10.

Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.

New psychoactive substances (NPS) with amphetamine-, aminoindan-, and benzofuran basic chemical structures have recently emerged for recreational drug use. Detailed information about their psychotropic effects and health risks is often limited. At the same time, it emerged that the pharmacological profiles of these NPS resemble those of amphetamine or 3,4-methylenedioxymethamphetamine (MDMA). Read More

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http://dx.doi.org/10.1007/164_2018_113DOI Listing
April 2018
9 Reads

Repeated Administration of 3,4-Methylenedioxymethamphetamine (MDMA) Elevates the Levels of Neuronal Nitric Oxide Synthase in the Nigrostriatal System: Possible Relevance to Neurotoxicity.

Neurotox Res 2018 Nov 9;34(4):763-768. Epub 2018 Apr 9.

Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Building A, Monserrato University Campus, SP 8, Km 0.700, 09042, Monserrato, Italy.

Previous studies have consistently demonstrated that the amphetamine-related drug 3,4-methylenedioxymethamphetamine (MDMA) induces dopaminergic damage in the mouse brain, and that this effect is most marked in the nigrostriatal system. Moreover, it has been suggested that the overproduction of nitric oxide (NO) may participate in the dopaminergic damage induced by MDMA. To further elucidate this issue, we evaluated the levels of the enzyme nitric oxide synthase (nNOS), which catalyzes the production of NO, in mice treated with regimens of MDMA that induce progressive and persistent neurotoxicity in the dopaminergic nigrostriatal system. Read More

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http://dx.doi.org/10.1007/s12640-018-9892-4DOI Listing
November 2018
1 Read

Rewarding and reinforcing effects of 4-chloro-2,5-dimethoxyamphetamine and AH-7921 in rodents.

Neurosci Lett 2018 May 5;676:66-70. Epub 2018 Apr 5.

Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi 28159, Republic of Korea.

New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Read More

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http://dx.doi.org/10.1016/j.neulet.2018.04.009DOI Listing
May 2018
4 Reads

Effect of methamphetamine exposure on the plasma levels of endothelial-derived microparticles.

Drug Alcohol Depend 2018 05 27;186:219-225. Epub 2018 Mar 27.

Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background: Methamphetamine (Meth), a neurotoxin, induces inflammation, oxidative stress, and triggers endothelial dysfunction and cardiovascular disease which is the second cause of death among individuals with Meth-use disorder. Oxidative stress and inflammation trigger the microparticle (MP) release. These are extracellular vesicles extracted from cell surface and identified in biological fluids. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.02.015DOI Listing
May 2018
4 Reads

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice.

Int J Dev Neurosci 2018 Jun 20;67:37-45. Epub 2018 Mar 20.

Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy. However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance. Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2018.03.005DOI Listing
June 2018
13 Reads

Drug- and/or trauma-induced hyperthermia? Characterization of HSP70 and myoglobin expression.

PLoS One 2018 22;13(3):e0194442. Epub 2018 Mar 22.

Rudolf Boehm Institute of Pharmacology and Toxicology, Medical Faculty, University of Leipzig, Leipzig, Germany.

Introduction: Heat shock protein 70 (HSP70) expression could be discussed as an adaption that promotes repair and counteracts cell damage. Myoglobin is released upon muscle damage of several pathways. The purpose of the present study was to determine whether the expression of HSP70 in kidney, heart and brain and of myoglobin in the kidney were associated with the cause of death and the survival times after lethal intoxications with three of the drugs most widely used in our local area (Saxony, Germany) as well as after fatal traumatic brain injury (TBI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194442PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864017PMC
July 2018
8 Reads

The Influence of High and Low Doses of Bisphenol A (BPA) on the Enteric Nervous System of the Porcine Ileum.

Int J Mol Sci 2018 Mar 20;19(3). Epub 2018 Mar 20.

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Str. 13, 10-719 Olsztyn, Poland.

Bisphenol A, used in the production of plastic, is able to leach from containers into food and cause multidirectional adverse effects in living organisms, including neurodegeneration and metabolic disorders. Knowledge of the impact of BPA on enteric neurons is practically non-existent. The destination of this study was to investigate the influence of BPA at a specific dose (0. Read More

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http://dx.doi.org/10.3390/ijms19030917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877778PMC
March 2018
2 Reads

Lactulose attenuates METH-induced neurotoxicity by alleviating the impaired autophagy, stabilizing the perturbed antioxidant system and suppressing apoptosis in rat striatum.

Toxicol Lett 2018 Jun 14;289:107-113. Epub 2018 Mar 14.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515 Guangzhou, China. Electronic address:

Methamphetamine (METH) is a widely abused psychostimulant. Lactulose is a non-absorbable sugar, which effectively decreases METH-induced neurotoxicity in rat. However, the exact mechanisms need further investigation. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.03.015DOI Listing
June 2018
5 Reads

Amphetamine Neurotoxicity in PC12 Cells through the PP2A/AKT/GSK3β Pathway.

Neurotox Res 2018 08 6;34(2):233-240. Epub 2018 Mar 6.

Department of Anatomy, Medical College of Jinan University, Guangzhou, 510632, China.

Amphetamine (AMPH) abuse can influence neuropsychiatric disorders and cell apoptosis by interfering with the protein kinase B/ glycogen synthase kinase 3 beta (AKT/GSK3β) pathway. However, the mechanisms underlying this regulation are poorly understood. Using PC12 cells, we found that AMPH inhibited AKT and GSK-3β phosphorylation levels and increased total GSK-3β levels. Read More

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http://dx.doi.org/10.1007/s12640-018-9880-8DOI Listing
August 2018
1 Read

Cross-sectional cause of death comparisons for stimulant and opioid mortality in San Francisco, 2005-2015.

Drug Alcohol Depend 2018 04 21;185:305-312. Epub 2018 Feb 21.

San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA, United States; Department of Medicine, Division of HIV, Infectious Disease and Global Health, University of California, San Francisco, CA, United States.

Background: Opioids and stimulants (e.g., cocaine or methamphetamine/amphetamine [MAMP]) are major contributors to acute substance toxicity deaths. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2017.12.030DOI Listing
April 2018
8 Reads

An index of fatal toxicity for new psychoactive substances.

J Psychopharmacol 2018 Jul 27;32(7):793-801. Epub 2018 Feb 27.

2 Psychopharmacology, Drug Misuse & Novel Psychoactive Substances Research Unit, Department of Pharmacy, Pharmacology & Post-graduate Medicine, University of Hertfordshire, Hatfield, UK.

An index of fatal toxicity for new psychoactive substances has been developed based solely on information provided on death certificates. An updated index of fatal toxicity (T), as first described in 2010, was calculated based on the ratio of deaths to prevalence and seizures for the original five substances (amphetamine, cannabis, cocaine/crack, heroin and 3,4-methylenedioxymethylamphetamine). These correlated well with the 2010 index. Read More

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http://dx.doi.org/10.1177/0269881118754709DOI Listing
July 2018
6 Reads
3.590 Impact Factor

Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity.

BMC Complement Altern Med 2018 Feb 23;18(1):76. Epub 2018 Feb 23.

Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, 19 Xinjiekouwai Street, Haidian district, Beijing, China.

Background: Methamphetamine (METH) is a psychostimulant with high abuse liability that affects the monoamine neurotransmitter systems, particularly the dopamine system. Currently there are no effective medications for the treatment of METH abuse to restore METH-induced dopaminergic dysfunction. The Jitai tablet (JTT), a commercial traditional Chinese medicinal preparation, has been shown to modulate the dopaminergic function both in heroin addicts and in morphine-dependent rats. Read More

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http://dx.doi.org/10.1186/s12906-018-2094-zDOI Listing
February 2018
6 Reads

Peripheral Administration of Tetanus Toxin Hc Fragment Prevents MPP Toxicity In Vivo.

Neurotox Res 2018 07 19;34(1):47-61. Epub 2018 Feb 19.

Institut de Neurociències and Departament de Bioquímica i de Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain.

Several studies have shown that intrastriatal application of 1-methyl-4-phenylpyridinium (MPP) produces similar biochemical changes in rat to those seen in Parkinson's disease (PD), such as dopaminergic terminal degeneration and consequent appearance of motor deficits, making the MPP lesion a widely used model of parkinsonism in rodents. Previous results from our group have shown a neuroprotective effect of the carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) under different types of stress. In the present study, pretreatment with the intraperitoneal injection of Hc-TeTx in rats prevents the decrease of tyrosine hydroxylase immunoreactivity in the striatum due to injury with MPP, when applied stereotaxically in the striatum. Read More

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http://dx.doi.org/10.1007/s12640-017-9853-3DOI Listing
July 2018
4 Reads

A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats.

Neurotox Res 2018 04 9;33(3):671-680. Epub 2018 Feb 9.

Division of Neurology, Deptarment of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.

Methamphetamine (MA) alters dopamine markers and cognitive function in heavy users. In rodents, there are MA dosing regimens that induce concordant effects using repeated administration at spaced intervals. These regimens are effective but complicate experiments designed to disentangle the effects of the drug on different brain regions in relation to their cognitive effects because of treatment spacing. Read More

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http://dx.doi.org/10.1007/s12640-018-9871-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874175PMC
April 2018
3 Reads

Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents.

Pharmacol Res Perspect 2018 02;6(1)

CNS Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.

Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D receptor antagonism. TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one] is a novel phosphodiesterase 10A inhibitor that activates both direct and indirect pathway MSNs through increasing both cAMP and cGMP levels by inhibition of their degradation. The activation of indirect pathway MSNs through the distinct mechanism of action of these drugs raises the possibility of augmented pharmacological effects by combination therapy. Read More

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http://dx.doi.org/10.1002/prp2.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817828PMC
February 2018
2 Reads

Lead Poisoning in Opium Abuser in Iran: A Systematic Review.

Int J Prev Med 2018 5;9. Epub 2018 Jan 5.

Department of Clinical Toxicology, Excellent Center of Clinical Toxicology, Loghman Hakim Hospital Poison Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Substance abuse and its consequences are major health hazards in the world. Opium addiction is a common form of substance abuse in Iran. Adulteration of illegal substances in the process of production and distribution of the drug in black market with many types of materials have been reported. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_22_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787876PMC
January 2018
3 Reads

Chronic amphetamine treatment affects collicular-dependent behaviour.

Behav Brain Res 2018 05 3;343:1-7. Epub 2018 Feb 3.

School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK. Electronic address:

Distractibility can be defined as an attention deficit where orientation toward irrelevant targets cannot be inhibited. There is now mounting evidence that the superior colliculus is a key neural correlate of distractibility, with increased collicular-activity resulting in heightened distractibility. Heightened distractibility is reduced by amphetamine, which acutely suppresses collicular responsiveness. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.01.028DOI Listing
May 2018
2 Reads

[Underlying Mechanisms of Methamphetamine-Induced Self-Injurious Behavior and Lethal Effects in Mice].

Nihon Eiseigaku Zasshi 2018 ;73(1):51-56

National Institute of Public Health, Minsitry of Health Labour & Welfare.

Relatively high doses of psychostimulants induce neurotoxicity on the dopaminergic system and self-injurious behavior (SIB) in rodents. However the underlying neuronal mechanisms of SIB remains unclear. Dopamine receptor antagonists, N-methyl-D-aspartic acid (NMDA) receptor antagonists, Nitric Oxide Synthase (NOS) inhibitors and free radical scavengers significantly attenuate methamphetamine-induced SIB. Read More

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http://dx.doi.org/10.1265/jjh.73.51DOI Listing
February 2018
11 Reads

Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series.

Medicine (Baltimore) 2018 02;97(5):e9784

Division of Clinical Pharmacology and Toxicology, Basel University Hospital and University of Basel, Basel, Switzerland.

The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational drug toxicity during the study period, 831 could be included. Read More

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http://dx.doi.org/10.1097/MD.0000000000009784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805445PMC
February 2018
15 Reads

Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine.

Brain Res Bull 2018 03 31;137:356-362. Epub 2018 Jan 31.

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address:

Objectives: Bipolar disorder (BD) is a severe mental illness characterized by episodes of mania and depression. Numerous studies have implicated the involvement of endogenous cardiac steroids (CS), and their receptor, Na, K -ATPase, in BD. The aim of the present study was to examine the role of brain oxidative stress in the CS-induced behavioral effects in mice. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.01.016DOI Listing
March 2018
7 Reads

Ghrelin Alleviates MDMA-Induced Disturbance of Serum Glucose and Lipids Levels in the Rat.

Acta Med Iran 2017 Dec;55(12):736-743

Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Hepatotoxicity is one of the clinically adverse effects of ecstasy (3, 4-methylenedioxymethamphetamine; MDMA) consumption. The detoxification tissue, liver, plays a central role in maintaining circulating levels of glucose and lipid. Hypoglycemia and hypotriglyceridemia have been reported due to ecstasy abuse. Read More

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December 2017
11 Reads

Effects of amphetamine administration on neurogenesis in adult rats.

Folia Neuropathol 2017 ;55(4):333-339

In our study expression of phospho-(Ser-10)-histone H3 (pH3S10), a marker for the early stage of neurogenesis, and cellular early response genes were investigated using c-Fos protein as an example of a transcription factor in the neurogenic process in rats. Neurogenesis in the adult brain is regulated by endo- and exogenous factors, which influence the proliferation potential of progenitor cells and accelerate the dendritic development of newborn neurons. D-amphetamine, a psychoactive substance, is one of the exogenous factors able to influence the process of neurogenesis. Read More

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http://dx.doi.org/10.5114/fn.2017.72396DOI Listing
August 2018
4 Reads

Effects of perinatal stress and drug abuse on maternal behavior and sensorimotor development of affected progeny.

Physiol Res 2017 Dec;66(Supplementum 4):S481-S491

Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Methamphetamine (MA) is an addictive psychostimulant with significant potential for abuse. Previous rat studies have demonstrated that MA use during pregnancy impairs maternal behavior and induced delayed development of affected pups. The offspring of drug-addictive mothers were often neglected and exposed to neonatal stressors. Read More

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December 2017
3 Reads

Olfactory bulbectomy in methamphetamine-treated rat mothers induces impairment in somatic and functional development of their offspring.

Physiol Res 2017 Dec;66(Supplementum 4):S469-S479

Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Olfactory bulbectomy in rodents is considered a putative model of depression. Depression is often associated with drug addiction. Our previous studies demonstrated that methamphetamine (MA) administration to rat mothers affects both, mothers and their pups. Read More

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December 2017
2 Reads

Comprehensive review of cardiovascular toxicity of drugs and related agents.

Med Res Rev 2018 07 5;38(4):1332-1403. Epub 2018 Jan 5.

Department of Pharmacology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. Read More

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http://dx.doi.org/10.1002/med.21476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033155PMC
July 2018
12 Reads

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes.

Front Mol Neurosci 2017 12;10:409. Epub 2017 Dec 12.

School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Methamphetamine (METH) is an amphetamine-typed stimulant drug that is increasingly being abused worldwide. Previous studies have shown that METH toxicity is systemic, especially targeting dopaminergic neurons in the central nervous system (CNS). However, the role of neuroinflammation in METH neurotoxicity remains unclear. Read More

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http://dx.doi.org/10.3389/fnmol.2017.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733023PMC
December 2017
16 Reads

Key interindividual determinants in MDMA pharmacodynamics.

Expert Opin Drug Metab Toxicol 2018 Feb;14(2):183-195

a Departments of Clinical Pharmacology and Internal Medicine , Hospital Universitari Germans Trias I Pujol-IGTP , Badalona , Spain.

Introduction: MDMA, 3,4-methylenedioxymethamphetamine, is a synthetic phenethylamine derivative with structural and pharmacological similarities to both amphetamines and mescaline. MDMA produces characteristic amphetamine-like actions (euphoria, well-being), increases empathy, and induces pro-social effects that seem to motivate its recreational consumption and provide a basis for its potential therapeutic use. Areas covered: The aim of this review is to present the main interindividual determinants in MDMA pharmacodynamics. Read More

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http://dx.doi.org/10.1080/17425255.2018.1424832DOI Listing
February 2018
4 Reads

Fenfluramine-Phentermine is Associated with an Increase in Cellular Proliferation Ex Vivo and In Vitro.

J Heart Valve Dis 2017 07;26(4):467-471

Division of Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA.

Background And Aim Of The Study: Fenfluraminephentermine (FenPhen) has been implicated in accelerated valvular heart disease, characterized by valvular regurgitation and thickening, and resembling the histopathologic lesions found in carcinoid. The study aim was to determine whether cellular proliferation is present in FenPhen-exposed valves, by utilizing an in-vitro model to test whether FenPhen has a direct mitogenic effect on cardiac valvular cells, as compared to serotonin.

Methods: Ex-vivo valves were tested for proliferation in surgically removed FenPhen-exposed valves (n = 10) and compared to proliferation levels in normal human cardiac valves removed at autopsy (n = 10). Read More

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July 2017
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Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders.

Eur J Med Chem 2018 Jan 28;144:318-329. Epub 2017 Nov 28.

Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain. Electronic address:

A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhibiting its tyrosine phosphatase activity. The most potent compounds 10a and 12b (IC = 0,1 μM) significantly increase the phosphorylation of key tyrosine residues of PTPRZ1 substrates involved in neuronal survival and differentiation, and display protective effects against amphetamine-induced toxicity. Read More

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http://dx.doi.org/10.1016/j.ejmech.2017.11.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817915PMC
January 2018
36 Reads