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Aquat Toxicol 2022 Jun 13;249:106223. Epub 2022 Jun 13.

Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) Université de Caen Normandie UNICAEN, Sorbonne Université, MNHN, UPMC Univ Paris 06, UA, CNRS 8067, IRD 207, Esplanade de la paix, Caen F-14032, France. Electronic address:

Among the anthropogenic sources releasing metallic species into the marine environment, the galvanic anode cathodic protection system (GACP) is widely used to protect submerged metallic structures from corrosion. Galvanic anodes are an alloy of metals of which the main component is aluminum or zinc. Very few studies were performed to study their potential biological effects. Read More

Materials (Basel) 2022 Jun 15;15(12). Epub 2022 Jun 15.

Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, 3012 Bern, Switzerland.

Potassium aluminum sulfate (alum) is a known adjuvant, which has been used as a mordant in textile industry for color fixation. This material has potential to be incorporated into dentistry for color stability, yet its toxicity first needs to be evaluated. The present study aimed to evaluate the cytotoxic potential of potassium aluminum sulfate (alum) on fibroblasts when applied onto feldspathic ceramic before and after thermocycling. Read More

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

The State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China.

Aluminum (Al) toxicity is an essential factor that adversely limits soybean ( (L.) Merr.) growth in acid soils. Read More

Int J Environ Res Public Health 2022 Jun 10;19(12). Epub 2022 Jun 10.

Department of Chemical and Molecular Engineering, Hanyang University, 55 Hanyangdaehakro, Sangrok-gu, Ansan 15588, Korea.

The development of nanotechnology has increased concerns about the exposure of ecosystems to manufactured nanomaterials, the toxicities of which are now being researched. However, when manufactured nanomaterials are mixed with algae in a culture medium for ecotoxicity tests, the results are vulnerable to distortion by an agglomeration phenomenon. Here, we describe a dispersion method commonly applicable to ecotoxicity tests for the 14 types of manufactured nanomaterials specified by the Organisation of Economic Co-operation and Development's Sponsorship Programme, namely aluminum oxide (AlO), carbon black, single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), cerium oxide (CeO), dendrimers, fullerene, gold (Au), iron (Fe), nanoclays, silver (Ag), silicon dioxide (SiO), titanium dioxide (TiO), and zinc oxide (ZnO). Read More

Antioxidants (Basel) 2022 May 27;11(6). Epub 2022 May 27.

Division of Plant Biosciences, School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 41566, Korea.

The current study aimed to understand the synergistic impacts of silicon (Si; 1.0 mM) and boron (B; 10 µM) application on modulating physio-molecular responses of date palm to mitigate aluminum (Al; 2.0 mM) toxicity. Read More

New Phytol 2022 Jun 23. Epub 2022 Jun 23.

College of Horticulture, China Agricultural University, Beijing, 100193, China.

In acidic soils, Aluminum (Al) toxicity is the main factor inhibiting plant root development and reducing crops yield. STOP1 (SENSITIVE TO PROTON RHIZOTOXICITY 1) was a critical factor in detoxifying Al stress. Under Al stress, STOP1 expression was not induced, although STOP1 protein accumulated, even in the presence of RAE1 (STOP1 DEGRADATION E3-LIGASE). Read More

Arch Toxicol 2022 Jun 21. Epub 2022 Jun 21.

Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University (Sechenov University), 119435, Moscow, Russia.

Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron metabolism and induction of oxidative stress and lipid peroxidation, ferroptosis might be involved in such toxicity. Although direct evidence is insufficient, certain pioneering studies have demonstrated a crosstalk between metal toxicity and ferroptosis. Read More

Pestic Biochem Physiol 2022 Jun 11;184:105117. Epub 2022 May 11.

Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran; Students Research Committee, Faculty of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

Previous studies have demonstrated that phosphine gas (PH) released from aluminium phosphide (AlP) can inhibit cytochrome oxidase in cardiac mitochondria and induce generation of free radicals, oxidative stress, alteration in antioxidant defense system and cardiotoxicity. Available evidence suggests that cannabinoids have protective effects in the reduction of oxidative stress, mitochondrial and cardiovascular damages. The objective of this study was to evaluate the effect of trans-Δ-9-tetrahydrocannabinol (THC) on AlP-induced toxicity in isolated cardiomyocytes and cardiac mitochondria. Read More

J Hazard Mater 2022 Jun 3;437:129275. Epub 2022 Jun 3.

Microelement Research Center, College of Resources and Environment, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; The Key Laboratory of Oasis Eco-agriculture, Xinjiang Production and Construction Corps, Shihezi University, Shihezi, PR China. Electronic address:

Boron (B) is an indispensable micronutrient for plant growth that can also alleviate aluminum (Al) toxicity. However, limited data are available on the underlying mechanisms behind this phenomenon. Here, we found that a certain range of B application could alleviate the inhibitory effects of Al toxicity on citrus. Read More

BMC Plant Biol 2022 Jun 13;22(1):287. Epub 2022 Jun 13.

Botany and Microbiology Department, Faculty of Science, South Valley University, Qena, 83523, Egypt.

Background: To our knowledge, the role of exogenous fluoride (F) on aluminum (Al)-stress mitigation in plants has not been investigated yet. In this experiment, barley (Hordeum vulgaris) seedlings were exposed to excessive Al concentrations (aluminum chloride, 0.5, 1. Read More

Ecotoxicol Environ Saf 2022 Jun 10;241:113748. Epub 2022 Jun 10.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi Key Laboratory of Forest Ecology and Conservation, Forestry College, Guangxi University, Nanning, Guangxi, China. Electronic address:

Forest ecosystems play an important role in environmental protection and maintaining ecological balance. Understanding the physiological mechanisms of tree species response to aluminum (Al) toxic is crucial to reveal the main causes of plantation decline in acid rain area. As an important afforestation tree species in tropical and subtropical areas, Eucalyptus has high economic value and plays crucial ecological roles. Read More

Int Immunopharmacol 2022 Aug 6;109:108922. Epub 2022 Jun 6.

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. Electronic address:

Safe and effective vaccines are urgently needed to combat the COVID-19 pandemic. However, the SARS-CoV-2 variants raise concerns about the effectiveness of vaccines. As a SARS-CoV-2 antigen target, ORF8 strongly inhibits the IFN-β and NF-κB-responsive promoter, and can be potentially used for the development of SARS-CoV-2 vaccine. Read More

J Sci Food Agric 2022 Jun 9. Epub 2022 Jun 9.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, China.

Background: Aluminum (Al) toxicity caused by soil acidification is the main constraint for crop growth in tropical and subtropical areas of southern China. The critical values of soil solution Al activity and pH for crops in acidic soils can provide a useful reference for soil acidity amelioration.

Results: A pot experiment in a greenhouse was conducted to investigate the critical values of soil solution Al activity and pH for canola and maize in an Ultisol and an Alfisol. Read More

Sci Rep 2022 Jun 8;12(1):9473. Epub 2022 Jun 8.

School of Energy Power and Mechanical Engineering, North China Electric Power University, Beijing, 102206, China.

Transmission lines often suffer from conductor damage during operation, most of which are caused by excessive local stress of aluminum strands. However, one of the causes of conductor damage may be the tension paying off passing the pulley. At the same time, there are relatively few researches on the damage of conductor causing by passing pulley. Read More

Environ Sci Pollut Res Int 2022 Jun 6. Epub 2022 Jun 6.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh, Saudi Arabia.

Alzheimer's disease (AD) is a neurodegenerative disease (ND) that represents the principal cause of dementia. Effective treatment is still lacking. Without prevention, Alzheimer's disease (AD) incidence is expected to triple within 30 years. Read More

J Wildl Dis 2022 Jun 6. Epub 2022 Jun 6.

Halmos College of Arts and Sciences, Nova Southeastern University, 8000 N Ocean Drive, Dania Beach, Florida 33004, USA.

Concentrations of 15 trace elements (aluminum, arsenic, cadmium, chromium, cobalt, copper, iron, lead, manganese, mercury, nickel, selenium, tin, vanadium, and zinc) were determined in vibrissae (whiskers) and serum of two sympatric pinniped species, the Peruvian fur seal population (PFS; Arctocephalus australis Peruvian subpopulation) and South American sea lion (SASL; Otaria byronia, at Punta San Juan, Peru during 2011-2019 sampling events. Element concentrations were 2-20 times higher in vibrissae than in serum. Vibrissae and serum concentrations of several elements, including aluminum, arsenic, and lead, suggest that environmental contaminants may affect the health of pinnipeds at Punta San Juan. Read More

J Trace Elem Med Biol 2022 May 20;73:127003. Epub 2022 May 20.

Department of Occupational Health, School of Public Health, Shanxi Medical University, China; Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, China; Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, China. Electronic address:

Background: As an emerging nanomaterial, nano-alumina is widely used in chemical engineering, food and medicine due to its special physical and chemical properties, and its potential health hazards have attracted attention.

Objective: Aim of this study is to understanding the effect and possible mechanism of nano-alumina on cognitive function in mice.

Methods: Male healthy ICR mice were randomly assigned and given nasal drops of saline, nano-alumina (different doses) and micro-alumina for 30 days, respectively. Read More

Plant Cell Environ 2022 Jun 3. Epub 2022 Jun 3.

State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China.

Rice, as one of the most aluminium (Al)-resistant cereal crops, has developed more complicated Al resistance mechanisms than others. By using forward genetic screening from a rice ethyl methanesulfonate mutant library, we obtained a mutant showing specifically high sensitivity to Al. Through MutMap analysis followed by a complementation test, we identified the causal gene, Al-related Protein Kinase (ArPK) for Al-sensitivity. Read More

J Genet Genomics 2022 May 30. Epub 2022 May 30.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China. Electronic address:

Plasma membrane H-ATPases (PM H-ATPases) are critical proton pumps that export protons from the cytoplasm to the apoplast. The resulting proton gradient and difference in electrical potential energize various secondary active transport events. PM H-ATPases play essential roles in plant growth, development, and stress responses. Read More

Front Plant Sci 2022 16;13:754735. Epub 2022 May 16.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, United States.

Metal toxicities can be detrimental to a plant health, as well as to the health of animals and humans that consume such plants. Metal content of plants can be analyzed using colorimetric, atomic absorption- or mass spectroscopy-based methods. However, these techniques are destructive, costly and laborious. Read More

Sci Rep 2022 May 28;12(1):8972. Epub 2022 May 28.

Agriculture Engineering Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.

Sources and levels of heavy metals (HMs) in soil and dust of urban and suburban areas in Riyadh (industrial city) and Mahad AD'Dahab (mining area) cities in Saudi Arabia were reported in this study. Additionally, the concentrations of HMs in different soil particle size fractions (> 250, 63-250 and < 63 µm) were reported. Pollution extent, and ecological and human health risks associated with collected soil and dust samples were explored. Read More

Plant Physiol Biochem 2022 May 25;185:1-12. Epub 2022 May 25.

Microelement Research Center, College of Resources and Environment, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China; The Key Laboratory of Oasis Eco-agriculture, Xinjiang Production and Construction Corps, Shihezi University, Shihezi, PR China. Electronic address:

Aluminum (Al) toxicity has conspicuous detrimental effects on citrus production whereas boron (B) has been shown to alleviate its toxicity. Lignin plays a critical role in the cell wall extensibility and root elongation under stressed conditions. Hence, the interaction between B and Al on cell wall structure and lignin-related metabolic pathway was investigated in root of trifoliate orange (Poncirus trifoliata (L. Read More

Environ Geochem Health 2022 May 30. Epub 2022 May 30.

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Rd, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand.

Aluminum (Al) contamination in acidic soil is a major problem in paddy field, causing grain yield loss, especially in central plains of Thailand. The objective of this study was to assess Al content in the root tissues, its translocation to the leaves, and Al toxicity in three genotypes of rice, RD35 (local acidic-tolerant), Azucena (positive-check Al-tolerant), and IR64 (high yielding) under 0 (control) or 1 mM AlCl (Al toxicity) at pH 4.5. Read More

Environ Sci Pollut Res Int 2022 May 28. Epub 2022 May 28.

Beijing Key Laboratory of Farmland Soil Pollution Prevention-Control and Remediation, College of Resources and Environmental Sciences, China Agricultural University, No. 2 Yuanmingyuan west road, Haidian, Beijing, 100193, People's Republic of China.

Soil acidification is a problem widely occurring worldwide, which severely threaten food security and agricultural sustainability. Calcium lignosulfonate (CaLS), a cheap and ecofriendly compound, is used for the first time to amend acid soil by utilizing its unique organic and inorganic functional moieties simultaneously. Both column leaching and incubation experiments were conducted to investigate the comparative effects of CaLS (four rates at 5, 10, 15, 20 g kg) and compared with conventional amendments, including gypsum (5 g kg), lignin (5 g kg), L + G (each at 5 g kg), and control. Read More

Analyst 2022 Jun 13;147(12):2828-2833. Epub 2022 Jun 13.

College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.

A novel fluorescent probe BTD with aggregation induced emission (AIE) characteristics for the monitoring of Al was developed. This fluorescent probe could be used to detect Al in aqueous solution under mild conditions, along with high sensitivity and high selectivity. The detection limit of the probe BTD for Al is as low as 3. Read More

Environ Sci Pollut Res Int 2022 May 26. Epub 2022 May 26.

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

This study aims to investigate the effect of Premna odorata (P. odorata) (Lamiaceae) on the hepatic and nephrotoxicity induced by aluminum chloride (AlCl) in rat. Wistar male rats were equally classified into four groups: control, P. Read More

BMC Plant Biol 2022 May 24;22(1):258. Epub 2022 May 24.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, Guangdong, 510642, People's Republic of China.

Ethylene response factor (ERF) transcription factors constitute a subfamily of the AP2/ERF superfamily in plants and play multiple roles in plant growth and development as well as in stress responses. In this study, the GsERF1 gene from the wild soybean BW69 line (an Al-resistant Glycine soja line) was rapidly induced in response to aluminum stress. Quantitative real-time PCR (qRT-PCR) analysis showed that the GsERF1 gene maintained a constitutive expression pattern and was induced in soybean in response to aluminum stress, with increased amounts of transcripts detected in the roots. Read More

Neurotoxicology 2022 May 20;91:245-253. Epub 2022 May 20.

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical sciences, Shiraz, Iran. Electronic address:

Aluminum (Al) is known to induce neurotoxicity in both humans and rodents. Recent evidence has indicated that the toxicity of Al Oxide (AlO) nanoparticles (Al-NP), one of the most abundantly used engineered nanoparticles, is far greater than that of Al itself. To date, however, no information is available regarding the effect of Al-NP on the stereological parameters of hippocampus. Read More

Environ Pollut 2022 Aug 19;307:119414. Epub 2022 May 19.

Department of General Microbiology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Red Sea Research Center (RSRC), Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. Electronic address:

Micropollutants (MPs) include a wide range of biological disruptors that can be toxic to wildlife and humans at very low concentrations (<1 μg/L). These mainly anthropogenic pollutants have been widely detected in different areas of the planet, including the deep sea, and have impacts on marine life. Because of this potential toxicity, the global distribution, quantity, incidence, and potential impacts of deep-sea MPs were investigated in a systematic review of the literature. Read More

Plant J 2022 May 21. Epub 2022 May 21.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.

Modification of the O-acetylation level of xyloglucan (XyG) appears to affect aluminum (Al) sensitivity in Arabidopsis by modulating its binding capacity to Al. However, the transcriptional regulation of this process remains largely unknown. In our previous studies, we found that the expression of TRICHOME BIREFRINGENCE-LIKE27 (TBL27), which is responsible for the O-acetylation of XyG, was downregulated under Al stress. Read More