5,894 results match your criteria Toxicity Aluminum


Transcriptome analysis of Cryptococcus humicola under aluminum stress revealed the potential role of the cell wall in aluminum tolerance.

Metallomics 2020 Jul 1. Epub 2020 Jul 1.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.

Aluminum (Al) toxicity is one of the most important limiting factors for crop yield in acidic soils. Bound Al gets converted into a toxic ionic state (Al3+) in acidic soil. Recent studies have shown that Al can act on the cell walls, cell membranes, organelles, and nuclei of microorganisms and affect substance and energy metabolism. Read More

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http://dx.doi.org/10.1039/d0mt00042fDOI Listing

Coexistence of diverse heavy metal pollution magnitudes: Health risk assessment of affected cattle and human population in some rural regions, Qena, Egypt.

J Adv Vet Anim Res 2020 Jun 10;7(2):345-359. Epub 2020 May 10.

Department of Biology, Faculty of Science, King Khalid University, Abha, Saudi Arabia.

Objective: The purpose of this study was to measure the mean concentrations of heavy metals including aluminum (Al), arsenic, nickel (Ni), mercury, lead (Pb), and cadmium (Cd) and to assess the health hazards due to the exposure of cattle/human population to a distinct or the mixture of heavy metals through various sources.

Materials And Methods: A total of 180 samples including water sources, animal feed, and raw cows' milk from rural regions in Qena, Egypt, were examined using the inductively coupled plasma emission spectrometer (ICP; iCAP 6200).

Results: The data highlighted heavy metal pollution with variable concentrations among most of the investigated regions. Read More

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http://dx.doi.org/10.5455/javar.2020.g428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320808PMC

Polycyclic aromatic compounds (PACs) in the Canadian environment: Exposure and effects on wildlife.

Environ Pollut 2020 Jun 13;265(Pt B):114863. Epub 2020 Jun 13.

Institut National de la Recherche Scientifique (INRS), Centre Eau Terre Environnement, Quebec, QC, Canada. Electronic address:

Polycyclic aromatic compounds (PACs) are ubiquitous in the environment. Wildlife (including fish) are chronically exposed to PACs through air, water, sediment, soil, and/or dietary routes. Exposures are highest near industrial or urban sites, such as aluminum smelters and oil sands mines, or near natural sources such as forest fires. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114863DOI Listing

Iron-rich air pollution nanoparticles: An unrecognised environmental risk factor for myocardial mitochondrial dysfunction and cardiac oxidative stress.

Environ Res 2020 Jun 21;188:109816. Epub 2020 Jun 21.

The University of Montana, Missoula, MT, 59812, USA; Universidad Del Valle de México, 14370, Mexico.

Exposure to particulate air pollution is a major environmental risk factor for cardiovascular mortality and morbidity, on a global scale. Both acute and chronic cardiovascular impacts have so far been attributed to particulate-mediated oxidative stress in the lung and/or via 'secondary' pathways, including endothelial dysfunction, and inflammation. However, increasing evidence indicates the translocation of inhaled nanoparticles to major organs via the circulation. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306213PMC

Effect of nitrogen (N) deposition on soil-N processes: a holistic approach.

Sci Rep 2020 Jun 26;10(1):10470. Epub 2020 Jun 26.

Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

Nitrogen (N) deposition is a serious environmental issue for soil fertility and human wellbeing. Studies on various terrestrial ecosystems yielded fragmented information on soil-N status (microbial biomass- and mineral-N) and dynamics (N-mineralization and -leaching) whereas the holistic view on this issue is relatively unknown. A complete understanding of soil-N status and dynamics in response to N deposition is essential for sustainable management of ecosystem structure and function as needed for human wellbeing. Read More

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http://dx.doi.org/10.1038/s41598-020-67368-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320165PMC

Calcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation.

Cardiovasc Toxicol 2020 Jun 25. Epub 2020 Jun 25.

Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, 71130-3932, USA.

One characteristic of ethylene glycol overdose is a cardiopulmonary syndrome including hypertension and pulmonary edema with pathology indicating damage to the endothelium of heart, lung and brain vessels. The mechanism of the cardiopulmonary toxicity is unknown, but has been linked with accumulation of the metabolite calcium oxalate monohydrate (COM) in the endothelium. These studies have evaluated the hypothesis that COM or the oxalate ion produces endothelial damage in vitro and that damage is linked with induction of reactive oxygen species (ROS). Read More

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http://dx.doi.org/10.1007/s12012-020-09584-4DOI Listing

HvHOX9, a Novel Homeobox Leucine Zipper Transcription Factor Revealed by Root miRNA and RNA Sequencing in Tibetan Wild Barley, Positively Regulates Al Tolerance.

J Exp Bot 2020 Jun 26. Epub 2020 Jun 26.

Department of Agronomy, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, P.R. China.

Aluminum (Al) toxicity is the primary limiting factor of crop production on acid soils. Tibetan wild-barley germplasm is a precious source of potential genes for breeding barley with acid and Al tolerance. microRNA and RNA sequencing were performed using wild (XZ16, Al-tolerant; XZ61, Al-sensitive) and cultivated (Dayton, Al-tolerant) barley. Read More

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http://dx.doi.org/10.1093/jxb/eraa290DOI Listing

Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils.

Exp Mol Pathol 2020 Jun 23;116:104486. Epub 2020 Jun 23.

Department of Histology, Embryology and Cell Biology, Laboratory of Microscopy Applied to Reproduction, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás 74001970, Brazil. Electronic address:

Since the industrial revolution, all living beings have become susceptible to numerous sources of aluminum (Al) exposure. In addition to causing proven toxicity in many organs and systems, Al can also have estrogenic activity when absorbed by the body. The reproductive organs are commonly affected by environmental pollutants with estrogenic activity, but little is known about the effects of Al on the prostate and gonads. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104486DOI Listing

Lizards as model organisms to evaluate environmental contamination and biomonitoring.

Environ Monit Assess 2020 Jun 24;192(7):454. Epub 2020 Jun 24.

Departamento de Botânica e Zoologia, Laboratório de Herpetologia, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Environmental contamination is reaching ever higher levels and affecting several animal populations, including humans. In this context, studies are being developed to monitor and evaluate this environmental problem using bioindicators organisms, in addition to testing the toxicity of contaminants in the laboratory. In this perspective, reptiles are ideal animals for these types of studies, considering that they are ectothermic and have a slower metabolism directly influencing their recovery power, and therefore, they are more sensitive to xenobiotic effects. Read More

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http://dx.doi.org/10.1007/s10661-020-08435-7DOI Listing

Improved Root Growth by Liming Aluminum-Sensitive Rice Cultivar or Cultivating an Aluminum-Tolerant One Does Not Enhance Fertilizer Nitrogen Recovery Efficiency in an Acid Paddy Soil.

Plants (Basel) 2020 Jun 19;9(6). Epub 2020 Jun 19.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.

The root is the main site of nitrogen (N) acquisition and aluminum (Al) toxicity. The objective of this study is to investigate whether liming and cultivation of an Al-tolerant rice ( L.) cultivar can improve root growth, thereby increasing N acquisition by rice plants in acid paddy soil. Read More

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http://dx.doi.org/10.3390/plants9060765DOI Listing

Liming effects of poultry litter derived biochar on soil acidity amelioration and maize growth.

Ecotoxicol Environ Saf 2020 Jun 19;202:110865. Epub 2020 Jun 19.

Soil Science Division, Bangladesh Agricultural Research Institute, Gazipur, 1701, Bangladesh.

Crop production in acid soils is facing enormous challenges due to low soil quality associated with an increase in the acidification rate and aluminum toxicity. Despite comprehensive prior work with biochar application on nutrient availability and crop productivity in acid soils, little information is available about the recommendation or standardization of biochar application rates that are more suitable for soil fertility improvement under different soil environments (physico-chemical properties) for maximizing the benefits of biochar applications and minimizing the potential environmental risk. Thus, the objective of this study was to investigate the effectiveness of poultry litter (PL) and poultry litter biochar (PLB) in ameliorating the fertility of acid soils through incubation and pot experiments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110865DOI Listing

Response of Vallisneria natans to aluminum phytotoxicity and their synergistic effect on nitrogen, phosphorus change in sediments.

J Hazard Mater 2020 Jun 12;400:123167. Epub 2020 Jun 12.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. Electronic address:

Increasing aluminum (Al) use and its effects on aquatic systems have been a global issue, however the Al impacts on submerged plants and their ecological functions were poorly understood. Aquatic simulation experiments were performed to study Al-toxicity on the germination and seedling morphological and physiological characteristics of Vallisneria natans, and investigate their synergistic effect on nitrogen (N), phosphorus (P) change and microbial community in sediment. The seeds germination characteristics, growth and physiological parameters of seedlings, including root activity, were significantly affected by alum treatments and the inhibition levels increased with Al concentration. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123167DOI Listing

Plasma membrane proteomic analysis by TMT-PRM provides insight into mechanisms of aluminum resistance in tamba black soybean roots tips.

PeerJ 2020 10;8:e9312. Epub 2020 Jun 10.

Southwest University, College of Animal Science and Technology, Chongqing, China.

Aluminum (Al) toxicity in acid soil is a worldwide agricultural problem that inhibits crop growth and productivity. However, the signal pathways associated with Al tolerance in plants remain largely unclear. In this study, tandem mass tag (TMT)-based quantitative proteomic methods were used to identify the differentially expressed plasma membrane (PM) proteins in Tamba black soybean (TBS) root tips under Al stress. Read More

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http://dx.doi.org/10.7717/peerj.9312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293186PMC

Elucidation of electrocoagulation mechanism in the removal of Blue SI dye from aqueous solution using Al-Al, Cu-Cu electrodes - A comparative study.

Ecotoxicol Environ Saf 2020 Jun 17;201:110858. Epub 2020 Jun 17.

Water Institute, Karunya Institute of Technology and Sciences (Deemed to Be University), Karunya Nagar, Coimbatore, 641 114, India.

This work presents the research on the treatment of an anthraquinone derivatives of disperse dye Blue SI from aqueous solution using aluminium for the optimization of operational parameters like pH, current density, addition of electrolyte, contact time for the color removal efficiency (CRE) and the results are compared with the performance of copper electrodes in electrocoagulation (EC). The parameters for maximum CRE was found with Al at current density 40 Am, time 10 min at pH 7, and for Cu at 60 Am 15 min, at pH 6 were optimized. The characterization of the treated water using HPLC, MS studies revealed intermediate compounds. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110858DOI Listing

Physiological, anatomical and ultrastructural effects of aluminum on Styrax camporum, a native Cerrado woody species.

J Plant Res 2020 Jun 19. Epub 2020 Jun 19.

Departamento de Biodiversidade, Instituto de Biociências, Universidade Estadual Paulista, UNESP, Av. 24-A, 1515, Rio Claro, SP, 13506-900, Brazil.

Styrax camporum Pohl. (Styracaceae) is a woody species that grows on acidic soils from the Brazilian savanna with high aluminum (Al) saturation (m% > 50%), where it accumulates ~ 1500 mg Al per kg dry leaves. Using nutrient solution, a previous study showed that 1480 μM Al causes toxicity symptoms, which raises the question whether less than 1480 μM Al could cause beneficial effects on this species. Read More

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http://dx.doi.org/10.1007/s10265-020-01210-2DOI Listing

Comparative Transcriptome Analysis of Two Contrasting Soybean Varieties in Response to Aluminum Toxicity.

Int J Mol Sci 2020 Jun 17;21(12). Epub 2020 Jun 17.

National Key Laboratory of Crop Genetics and Germplasm Enhancement, National Center for Soybean Improvement, Key Laboratory for Biology and Genetic Improvement of Soybean (General, Ministry of Agriculture), Jiangsu Collaborative Innovation Center for Modern Crop Production, Nanjing Agricultural University, Nanjing 210095, China.

Aluminum (Al) toxicity is a major factor limiting crop productivity on acid soils. Soybean () is an important oil crop and there is great variation in Al tolerance in soybean germplasms. However, only a few Al-tolerance genes have been reported in soybean. Read More

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http://dx.doi.org/10.3390/ijms21124316DOI Listing
June 2020
2.862 Impact Factor

Aluminum relieves fluoride stress through stimulation of organic acid production in .

Physiol Mol Biol Plants 2020 Jun 2;26(6):1127-1137. Epub 2020 May 2.

College of Horticulture, Nanjing Agricultural University, Nanjing, 210095 China.

Tea plants ( O. Kuntze) can hyperaccumulate fluoride (F) in leaves. Although, aluminum (Al) can alleviate F toxicity in , the mechanisms driving this process remain unclear. Read More

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http://dx.doi.org/10.1007/s12298-020-00813-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266864PMC

Rhizosphere Soil Fungal Communities of Aluminum-Tolerant and -Sensitive Soybean Genotypes Respond Differently to Aluminum Stress in an Acid Soil.

Front Microbiol 2020 28;11:1177. Epub 2020 May 28.

The State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou, Guangdong, China.

Different soybean genotypes can differ in their tolerance toward aluminum stress depending on their rhizosphere-inhabiting microorganisms. However, there is limited understanding of the response of fungal communities to different aluminum concentrations across different genotypes. Here, we used metabarcoding of fungal ribosomal markers to assess the effects of aluminum stress on the rhizosphere fungal community of aluminum-tolerant and aluminum-sensitive soybean genotypes. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270577PMC

Neurotoxic effects of combined exposures to aluminum and mercury in early life (infancy).

Authors:
José G Dórea

Environ Res 2020 Jun 8;188:109734. Epub 2020 Jun 8.

Universidade de Brasília, Brasília, 70919-970, DF, Brazil. Electronic address:

Aluminum and mercury are environmentally ubiquitous. Individually they are both neurotoxic elements with shared neuro-pathogenic pathways: oxidative stress, altered neurotransmission, and disruption of the neuroendocrine and immune systems. In the infant, Al and Hg differ in type of exposure, absorption, distribution (brain access), and metabolism. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109734DOI Listing

Self- assembled lactoferrin-conjugated linoleic acid micelles as an orally active targeted nanoplatform for Alzheimer's disease.

Int J Biol Macromol 2020 Jun 9;162:246-261. Epub 2020 Jun 9.

Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt. Electronic address:

Alzheimer's disease (AD) is neurological disorder characterized by dementia which causes severe problems with behavior, thinking and memory. Systemic administration of therapeutics to the central nervous system (CNS) is usually associated with very low efficiency due to presence of blood brain barrier (BBB), which only allows permeation of few types of molecules from the circulation to the CNS. As an alternative, naturally amphiphilic micelles can be utilized to enhance targeted drug delivery to the brain. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.058DOI Listing

Apigenin attenuates Aluminum phosphide-induced cytotoxicity via reducing mitochondrial/Lysosomal damages and oxidative stress in rat Cardiomyocytes.

Pestic Biochem Physiol 2020 Jul 19;167:104585. Epub 2020 Apr 19.

Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address:

Apigenin, is a natural compound that found in high amounts in vegetables and fruits. This natural flavone has shown strong cardioprotective effects in animal and clinical studies. Due to cardioprotective effects of apigenin in previous studies, we hypothesized that apigenin protects isolated cardiomyocytes from aluminum phosphide(AlP)-induced toxicity as the most common disturbances after exposure with this agent. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104585DOI Listing

Updated Multiple Linear Regression (MLR) Models for Predicting Chronic Aluminum Toxicity to Freshwater Aquatic Organisms and Developing Water Quality Guidelines.

Environ Toxicol Chem 2020 Jun 5. Epub 2020 Jun 5.

Red Cap Consulting, 7760 North Boulder Drive, Lake Point, UT, USA, 84074.

Multiple linear regression (MLR) models for predicting chronic aluminum toxicity to a cladoceran (Ceriodaphnia dubia) and a fish (Pimephales promelas) as a function of three toxicity modifying factors (TMFs) - dissolved organic carbon (DOC), pH, and hardness - were previously published. However, the range over which data for these TMFs were available was somewhat limited. To address this limitation, additional chronic toxicity tests with these species were subsequently conducted to expand the DOC range up to 12 mg/L, the pH range up to 8. Read More

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http://dx.doi.org/10.1002/etc.4796DOI Listing

Synchrotron Fourier transform infrared microspectroscopy (sFTIRM) analysis of Al-induced Alzheimer's disease in rat brain cortical tissue.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Oct 5;239:118421. Epub 2020 May 5.

Spectroscopy Dept., Physics Division, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.) Dokki, P.O. Box 12622, Giza, Egypt.

Aluminium (Al) is reported to promote beta amyloid (Aβ) aggregation, free radical production and disturb acetylcholine metabolism leading to cognitive dysfunction that are strongly associated with Alzheimer's disease (AD). Here we utilized synchrotron Fourier transform infrared microspectroscopy (sFTIRM) to analyse the fine structure of proteins and lipids in the rat cortical brain tissues in response to AlCl toxicity and Lepidium sativum (LS) treatment after 42 and 65 days. For statistical analysis, we used principal component analysis (PCA). Read More

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http://dx.doi.org/10.1016/j.saa.2020.118421DOI Listing
October 2020

Relationship between occupational aluminium exposure and histone lysine modification through methylation.

J Trace Elem Med Biol 2020 May 18;61:126551. Epub 2020 May 18.

Department of Occupational Health, School of Public Health, Shanxi Medical University, China; Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, China; Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, China. Electronic address:

Background: Aluminium is an environmental neurotoxin to which human beings are extensively exposed. However, the molecular mechanism of aluminium toxicity remains unclear.

Methods: The changes in cognitive function of aluminum exposed workers under long-term occupational exposure were evaluated, and the relationship between cognitive changes, plasma memory related BDNF and EGR1 protein expression, and variations of epigenetic markers H3K4me3, H3K9me2, H3K27me3 expression levels in blood was explored. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126551DOI Listing

Chemical characterization and in vivo antioxidant activity of parsley (Petroselinum crispum) aqueous extract.

Food Funct 2020 Jun;11(6):5346-5356

Departamento de Ciências Farmacêuticas, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, BR-465, Km 7, Seropédica, Rio de Janeiro, CEP: 23897-000, Brazil.

Twenty-nine flavonoid glycosides were identified in the aqueous extract (PC) of Petroselinum crispum var. crispum leaves and apiin, the major compound, was isolated thereof. Apigenin was obtained (90% purity) by the hydrolysis of apiin. Read More

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http://dx.doi.org/10.1039/d0fo00484gDOI Listing

Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer's diseases-In vitro.

J Food Biochem 2020 May 26:e13276. Epub 2020 May 26.

Functional Foods, Nutraceuticals and Phytomedicine Laboratory, Department of Biochemistry, Federal University of Technology Akure, Akure, Nigeria.

This research work examined and likened effect of eugenol a natural phenolic compound with butylated hydroxylanisole (BHA) and butylated hydroxyl toluene (BHT) synthetic phenolic compounds with key biomolecules [acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase (MAO)] relevant to Alzheimer's diseases (AD) in vitro. Ten millimolar each sample was prepared in a mixture of ethanol and water (1:1 v/v), and the interactions with AChE, BChE, and MAO were evaluated. Still, ferric reducing antioxidant property, ABTS radicals scavenging ability and lipid peroxidation were carried out. Read More

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http://dx.doi.org/10.1111/jfbc.13276DOI Listing

Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats.

Evid Based Complement Alternat Med 2020 11;2020:5602597. Epub 2020 May 11.

Department of Neurology, Baoding No. 1 Central Hospital, Baoding, Hebei 071000, China.

Objective: The present study was designed to evaluate the neuroprotective effects of D-(-)-quinic acid on aluminum chloride- (AlCl-) induced neurobehavioral and biochemical changes in rats. This study showed the behavioral and biochemical effects of D-(-)-quinic acid on rats with particular emphasis on the hippocampus and frontal cortex which are associated with memory.

Materials And Methods: Chronic administration of aluminum chloride at a dose of 175 mg/kg, p. Read More

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http://dx.doi.org/10.1155/2020/5602597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240662PMC
May 2020
1.880 Impact Factor

Toxicological testing of a photoactive phthalocyanine-based antimicrobial substance.

Regul Toxicol Pharmacol 2020 May 23;115:104685. Epub 2020 May 23.

Department of Medical Biophysics, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic.

The aim of the study was toxicological testing of an innovative and efficient antimicrobial agent based on photoactive phthalocyanine (Pc) derivative. A promising Aluminium phthalocyanine (AlPc) with efficient and stable antimicrobial effects was subjected to a battery of toxicological tests to avoid local and systemic toxicity hazard. In compliance with the current European legislation restricting the use of experimental animals, the methods comprised exclusively in vitro procedures based on cellular and tissue models of human origin or mimicking human tissues. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104685DOI Listing
May 2020
2.031 Impact Factor

Effects of crop straw biochars on aluminum species in soil solution as related with the growth and yield of canola (Brassica napus L.) in an acidic Ultisol under field condition.

Environ Sci Pollut Res Int 2020 May 25. Epub 2020 May 25.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, P.O. Box 821, Nanjing, China.

The toxicity of aluminum (Al) to plants in acidic soils depends on the Al species in soil solution. The effects of crop straw biochars on Al species in the soil solution, and canola growth and yield were investigated in this study. In a long-term field experiment, there were four treatments, which were a control, rice straw biochar (RSB), canola straw biochar (CSB), and peanut straw biochar (PSB). Read More

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http://dx.doi.org/10.1007/s11356-020-09330-xDOI Listing

Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity.

Vaccine 2020 Jun 19;38(30):4704-4712. Epub 2020 May 19.

Hennepin Healthcare Research Institute, Minneapolis, MN, United States; University of Minnesota Medical School, Department of Pharmacology, Minneapolis, MN, United States; University of Minnesota, Center for Immunology, Minneapolis, MN, United States. Electronic address:

Vaccines offer a potential strategy to treat opioid use disorders (OUD) and to reduce the incidence of opioid-related overdoses. Vaccines induce opioid-specific polyclonal antibodies that selectively and effectively bind the target opioid and prevent its distribution across the blood-brain barrier. Because antibody-mediated reduction of drug distribution to the brain reduces drug-induced behavior and toxicity, vaccine efficacy depends on the quantity and quality of the antibody response. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.027DOI Listing

Chrysin ameliorates aluminum phosphide-induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria.

Environ Toxicol 2020 May 20. Epub 2020 May 20.

Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

Apart from the anticancer, antioxidant, anti-inflammatory effects, and inhibition of aromatase, chrysin is involved in the protection of cardiovascular disorders. Cardiovascular complications are the main cause of death induced by aluminum phosphide (AlP) which is related to oxidative stress and mitochondrial damages. For this purpose, we investigated the effect of chrysin as an antioxidant and mitochondrial protective agent against AlP-induced toxicity in isolated cardiomyocytes and mitochondria obtained from rat heart ventricular. Read More

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http://dx.doi.org/10.1002/tox.22947DOI Listing

Aqueous Calcium-Ion Battery Based on a Mesoporous Organic Anode and a Manganite Cathode with Long Cycling Performance.

ChemSusChem 2020 May 19. Epub 2020 May 19.

Key Laboratory of Superlight Materials and Surface Technology of Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, PR China.

Aqueous batteries have attracted increasing and extensive attention, owing to their high safety, low cost, and low toxicity. These factors have become increasingly important, given the current focus on the rapid development of green energy technologies. In particular, multivalent-ion batteries are emerging as alternatives to lithium-ion batteries. Read More

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http://dx.doi.org/10.1002/cssc.202000812DOI Listing

MicroRNAs and Xenobiotic Toxicity: An Overview.

Toxicol Rep 2020 4;7:583-595. Epub 2020 May 4.

Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, 641 046, India.

The advent of new technologies has paved the rise of various chemicals that are being employed in industrial as well as consumer products. This leads to the accumulation of these xenobiotic compounds in the environment where they pose a serious threat to both target and non-target species. miRNAs are one of the key epigenetic mechanisms that have been associated with toxicity by modulating the gene expression post-transcriptionally. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225592PMC

Fagopyrum esculentum at early stages copes with aluminum toxicity by increasing ABA levels and antioxidant system.

Plant Physiol Biochem 2020 Apr 21;152:170-176. Epub 2020 Apr 21.

Instituto de Ecología, UNAM, Circuito exterior Universitario S/N anexo Jardín Botánico exterior Ciudad Universitaria, Mexico. Electronic address:

Aluminum toxicity (Al) is one of the main constraints for plant growth on acid soils. While most plants are sensitive to Al, some species have developed strategies to cope with this metal. Fagopyrum esculentum, Moench. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.04.024DOI Listing

Toxicity of binary mixtures of AlO and ZnO nanoparticles toward fibroblast and bronchial epithelium cells.

J Toxicol Environ Health A 2020 May 15;83(9):363-377. Epub 2020 May 15.

Department of Sanitary and Environmental Engineering, Federal University of Santa Catarina , Florianópolis, Brazil.

The objective of this study was to examine the cytotoxic effects of binary mixtures of AlO and ZnO NPs using mouse fibroblast cells (L929) and human bronchial epithelial cells (BEAS-2B) as biological test systems. The synergistic, additive, or antagonistic behavior of the binary mixture was also investigated. In toxicity experiments, cellular morphology, mitochondrial function (MTT assay), apoptosis, nuclear size and shape, clonogenic assays, and damage based upon oxidative stress parameters were assessed under control and NPs exposure conditions. Read More

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http://dx.doi.org/10.1080/15287394.2020.1761496DOI Listing

Indoor generated PM compositions and volatile organic compounds: Potential sources and health risk implications.

Chemosphere 2020 Sep 5;255:126932. Epub 2020 May 5.

Department of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia.

The aim of the present study was to investigate the potential sources of heavy metals in fine air particles (PM) and benzene, toluene, ethylbenzene, and isomeric xylenes (BTEX) in gas phase indoor air. PM samples were collected using a low volume sampler. BTEX samples were collected using passive sampling onto sorbent tubes and analyzed using gas chromatography-mass spectrometry (GC-MS). Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126932DOI Listing
September 2020

A case study applying pathway-oriented thinking to problem formulation for planning a systematic review.

Environ Int 2020 Jul 10;140:105768. Epub 2020 May 10.

Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland.

The use of evidence-based methods in chemical risk assessment (CRA) is still in its infancy. Novel approaches exploring how to implement Systematic Review (SR) principles and methods for evaluating human health risks from environmental chemical exposures are needed. This paper reports and comments on a conceptual model that was developed as part of a mapping exercise for planning a SR, using aluminium-containing antiperspirants (Al-AP) and female breast cancer risk as a case study. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105768DOI Listing

Growth of the aquatic macrophyte Ricciocarpos natans (L.) Corda in different temperatures and in distinct concentrations of aluminum and manganese.

Aquat Toxicol 2020 Jul 27;224:105484. Epub 2020 Apr 27.

Programa de Pós-graduação em Ecologia e Recursos Naturias, Laboratório de Bioensaios e Modelagem Matemática, Departamento de Hidrobiologia, Universidade Federal de São Carlos - UFSCAR, São Carlos, SP, Brazil.

One of the consequences of global mining is the exposure of metals into the environment, caused by the rupture of tailings dams. Excess of metals, such as aluminum (Al) and manganese (Mn) can cause serious damage to fauna and flora. The presence of these metals, associated with the temperature increase that occurs nowadays can potentially increase biochemical and metabolic rates in plant tissues and may affect growth. Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105484DOI Listing

In vitro toxicity assessment of respirable solid surface composite sawing particles.

Toxicol Ind Health 2020 Apr 7;36(4):250-262. Epub 2020 May 7.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA.

Solid surface composites (SSCs) are a class of popular construction materials composed of aluminum trihydrate and acrylic polymers. Previous investigations have demonstrated that sawing SSC releases substantial airborne dusts, with a number-based geometric mean diameter of 1.05 µm. Read More

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http://dx.doi.org/10.1177/0748233720921683DOI Listing

Performance of organic substrate amended constructed wetland treating acid mine drainage (AMD) of North-Eastern India.

J Hazard Mater 2020 Oct 18;397:122719. Epub 2020 Apr 18.

Department of Civil Engineering, Indian Institute of Technology Guwahati, Assam 781039, India. Electronic address:

A horizontal subsurface flow constructed wetland (HSSF-CW) was evaluated for the remediation of synthetic acid mine drainage (AMD) using an organic-rich substrate (cow manure and bamboo chips) planted with common cattail. The synthetic AMD simulated the source AMD generated in North Eastern Coalfield of Assam, India. The synthetic AMD was highly acidic (pH < 2. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122719DOI Listing
October 2020

Imaging of aluminium and amyloid β in neurodegenerative disease.

Heliyon 2020 Apr 25;6(4):e03839. Epub 2020 Apr 25.

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, United Kingdom.

Objectives: Recent research has confirmed the presence of aluminium in human brain tissue. Quantitative analyses suggest increased brain aluminium content in a number of neurodegenerative diseases including familial Alzheimer's disease, congophilic amyloid angiopathy, epilepsy and autism. Complementary aluminium-specific fluorescence microscopy identifies the location of aluminium in human brain tissue and demonstrates significant differences in distribution between diseases. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184253PMC

Phosphorus relieves aluminum toxicity in oil tea seedlings by regulating the metabolic profiling in the roots.

Plant Physiol Biochem 2020 Apr 24;152:12-22. Epub 2020 Apr 24.

Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees, Ministry of Education, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China. Electronic address:

Oil tea (Camellia oleifera Abel.) is an important edible oil tree mainly grown in acidic soils, whose growth and yield can be severely limited due to soil aluminum (Al) toxicity and phosphorus (P) deficiency. In this study, we investigated the physiological and metabolic responses of oil tea to Al and P treatment for an 8-week duration. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.04.030DOI Listing

Aluminum tolerance mechanisms in Kenyan maize germplasm are independent from the citrate transporter ZmMATE1.

Sci Rep 2020 Apr 30;10(1):7320. Epub 2020 Apr 30.

Embrapa Milho e Sorgo, Rodovia MG 424 km 65, Sete Lagoas, 35701-970, Brazil.

Aluminum (Al) toxicity on acid soils adversely affects maize yields, which can be overcome by combining soil amendments with genetic tolerance. In maize, ZmMATE1 confers Al tolerance via Al-activated citrate release, whereby citrate forms non-toxic complexes with Al in the rhizosphere. Here, we investigated Al tolerance mechanisms in maize germplasm originated from Kenya based on quantitative trait loci (QTL) mapping. Read More

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http://dx.doi.org/10.1038/s41598-020-64107-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193623PMC

Aluminum-induced alterations of purinergic signalling in embryonic neural progenitor cells.

Chemosphere 2020 Jul 3;251:126642. Epub 2020 Apr 3.

Post-Graduate Program in Biological Sciences: Toxicological Biochemistry, CCNE, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil. Electronic address:

The ubiquitous presence of aluminum in the environment leads to a high likelihood of human exposure. Neurotoxicity of the trivalent cationic form of this metal (Al3+) occurs in the central nervous system via accumulation of Al in cells of neural origin, including neural progenitor cells (NPCs). NPCs play a key role in the development and regeneration of the brain throughout life; therefore, this metal may contribute to neuropathological conditions. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126642DOI Listing

The effective adsorbent capacity of rice husk to iron and aluminum oxides nanoparticles using Oreochromis niloticus as a bioindicator: biochemical and oxidative stress biomarkers.

Environ Sci Pollut Res Int 2020 Jun 24;27(18):23159-23171. Epub 2020 Apr 24.

The Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt.

Metal oxide nanoparticles (NPs) have different industrial applications so it is unavoidable that NPs products could find their way into aquatic habitats. Therefore, toxic NPs must be treated sufficiently to reach the standard values before their discharge into the aquatic ecosystems. Our study aimed to investigate the adsorptive capacity of rice husk to iron and aluminum oxides from water and reducing their potential toxic effects. Read More

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http://dx.doi.org/10.1007/s11356-020-08906-xDOI Listing

Heterologous Expression of a C2H2 Zinc Finger Gene Improves Aluminum Tolerance in .

Int J Mol Sci 2020 Apr 15;21(8). Epub 2020 Apr 15.

The State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China.

Aluminum (Al) toxicity limits plant growth and has a major impact on the agricultural productivity in acidic soils. The zinc-finger protein (ZFP) family plays multiple roles in plant development and abiotic stresses. Although previous reports have confirmed the function of these genes, their transcriptional mechanisms in wild soybean () are unclear. Read More

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http://dx.doi.org/10.3390/ijms21082754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215988PMC

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress.

Molecules 2020 Apr 15;25(8). Epub 2020 Apr 15.

Institute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.

Aluminum accumulation, glutathione (GSH) and malondialdehyde (MDA) concentrations as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes and brain and liver homogenates of BALB/c mice treated with Al (7.5 mg/kg/day (0.15 LD) as AlCl (37. Read More

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http://dx.doi.org/10.3390/molecules25081807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221925PMC

Tolerance of Douglas Fir Somatic Plantlets to Aluminum Stress: Biological, Cytological, and Mineral Studies.

Plants (Basel) 2020 Apr 21;9(4). Epub 2020 Apr 21.

Laboratoire Peirene (EA7500), Faculté des Sciences et Techniques, Université de Limoges, 123, avenue Albert Thomas, F-87060 Limoges CEDEX, France.

Aluminum (Al) is well known as a potent inhibitor of plant growth and development. It is notably present in soils in the soluble and bioavailable form Al when the soil pH drops below 5. This situation is frequent, especially in softwood forests when litter decomposition is slow. Read More

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http://dx.doi.org/10.3390/plants9040536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238193PMC

White-tailed eagle (Haliaeetus albicilla) and great cormorant (Phalacrocorax carbo) nestlings as spatial sentinels of Baltic acidic sulphate soil associated metal contamination.

Sci Total Environ 2020 May 19;718:137424. Epub 2020 Feb 19.

Department of Biology, University of Turku, 20014 Turku, Finland.

Sulphate soils, characterised by low pH conditions, are found worldwide, and are potentially large sources of metal contamination, often exceeding industrial emissions. Metal leaching from sulphate soils has been shown to be harmful to aquatic organisms, but the cascading effect on exposure in apex avian predators has not been studied earlier. With the present study we aimed at evaluating the potential of white-tailed eagle (Haliaeetus albicilla) and great cormorant (Phalacrocorax carbo) nestlings, collected from nests located either in sulphate soil or control areas, for monitoring spatial contaminant trends of metals typically associated with sulphate soils. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.137424DOI Listing