37,000 results match your criteria Toxicity Alcohols

Choline-Amino Acid-Derived Bio-ionic Liquids for Solubility Enhancement of Zafirlukast.

AAPS PharmSciTech 2022 May 18;23(5):146. Epub 2022 May 18.

Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon, Pune, 411041, Maharashtra, India.

This study investigated the application of bio-ionic liquids (ILs) prepared from choline as cation and amino acid as anion for solubility enhancement of poorly water-soluble drug, Zafirlukast (ZFL). Herein, the solubility of ZFL in water and mixtures of water and ILs was assessed using UV spectroscopy at two temperature points 25°C and 37°C with increasing concentrations of IL. ZFL solubility was found to improve linearly with increasing concentration of [Ch][Pro] in water, representing 35- to 37-fold improvement in ZFL solubility at maximum concentration of [Ch][Pro] (1% w/v) compared to when only pure water was present. Read More

View Article and Full-Text PDF

Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses.

Transl Vis Sci Technol 2022 May;11(5):14

Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.

Purpose: Surgically implanted intraocular lenses (IOLs) may be used as drug-delivery devices, but their effectiveness is not well defined. Computational fluid dynamics models were developed to investigate the capability of IOLs to release drugs at therapeutic concentrations.

Methods: Models were generated using COMSOL Multiphysics. Read More

View Article and Full-Text PDF

Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses.

Acta Neuropathol Commun 2022 May 14;10(1):74. Epub 2022 May 14.

Department of Pathology, Normandy Centre for Genomic and Personalized Medicine, Laboratoire d'Anatomie Pathologique, Pavillon Jacques Delarue, CHU, Normandie Univ, UNIROUEN, INSERM U1245 and Rouen University Hospital, 1 Rue de Germont, 76031, Rouen Cedex, France.

Prenatal alcohol exposure is a major cause of neurobehavioral disabilities. MRI studies in humans have shown that alcohol is associated with white matter microstructural anomalies but these studies focused on myelin abnormalities only after birth. Only one of these studies evaluated oligodendrocyte lineage, but only for a short period during human foetal life. Read More

View Article and Full-Text PDF

Biodegradable Nanoparticles Loaded with Levodopa and Curcumin for Treatment of Parkinson's Disease.

Molecules 2022 Apr 28;27(9). Epub 2022 Apr 28.

Advanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba 80240-020, Brazil.

Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains the gold-standard drug available for treating PD. Curcumin has many pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, and antitumor properties. Read More

View Article and Full-Text PDF

Anthocyanins in Red Jasmine Rice ( L.) Extracts and Efficacy on Inhibition of Herpes Simplex Virus, Free Radicals and Cancer Cell.

Nutrients 2022 May 1;14(9). Epub 2022 May 1.

Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.

Rice is one of the most important food crops in many countries, with nutritional value and health benefits. In this study, the ethanolic and aqueous extracts of red jasmine rice from Chiang Mai, Thailand were examined for their anthocyanins and phenolic contents. The antioxidant and antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), as well as anticancer activity, were investigated. Read More

View Article and Full-Text PDF

Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function.

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Department of Histology, Cytology, and Embryology, Federal State Funded Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

Epinephrine is the most abundant catecholamine hormone, produced by the nervous system and adrenal glands. Endocrine disruption of epinephrine synthesis, secretion and signaling is less studied than steroid and thyroid hormones. Dichlorodiphenyltrichloroethane (DDT) is recognized as one of the most prominent environmental contaminants with a long half-life. Read More

View Article and Full-Text PDF

Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis.

Int J Mol Sci 2022 Apr 27;23(9). Epub 2022 Apr 27.

Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, China.

Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in maintaining the normal function of intestinal barrier and gut homeostasis in a mouse model of ALD. Read More

View Article and Full-Text PDF

Safety and efficacy of pegylated recombinant human granulocyte colony-stimulating factor during concurrent chemoradiotherapy for small-cell lung cancer: a retrospective, cohort-controlled trial.

BMC Cancer 2022 May 13;22(1):542. Epub 2022 May 13.

Shandong First Medical University, Jinan, 250000, Shandong, China.

Objective: To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing hematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell lung cancer (SCLC).

Methods: We retrospectively assessed 80 SCLC patients treated with CCRT from January 2013 to December 2018 who received PEG-rhG-CSF within 48 hours after the end of chemotherapy, defined as prophylactic use, as the experimental group. An additional 80 patients who were not treated with PEG-rhG-CSF were matched 1:1 by the propensity score matching method and served as the control group. Read More

View Article and Full-Text PDF

Proteome reallocation enables the selective de novo biosynthesis of non-linear, branched-chain acetate esters.

Metab Eng 2022 May 10. Epub 2022 May 10.

Department of Chemical and Biomolecular Engineering, The University of Tennessee, Knoxville, TN, USA; Center of Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, USA. Electronic address:

The one-carbon recursive ketoacid elongation pathway is responsible for making various branched-chain amino acids, aldehydes, alcohols, and acetate esters in living cells. Controlling selective microbial biosynthesis of these target molecules at high efficiency is challenging due to enzyme promiscuity, regulation, and metabolic burden. In this study, we present a systematic modular design approach to control proteome reallocation for selective microbial biosynthesis of branched-chain acetate esters. Read More

View Article and Full-Text PDF

Revisions to Limits for Propylene Glycol in Spacecraft Air.

Aerosp Med Hum Perform 2022 May;93(5):467-469

The previous Spacecraft Maximal Allowable Concentrations (SMACs) for propylene glycol were established based on a study of rodents exposed to propylene glycol (PG) aerosol for 6 h/d, 5 d/wk for 90 d. This study has been used as the basis for the few existing limits, but all exposure concentrations were well above the saturated vapor concentration of ∼100 ppm for pure propylene glycol at room temperature. For this reason, the Environmental Protection Agency and the Agency for Toxic Substances and Disease Registry noted that the method used to generate the aerosols for the two published studies of animal exposures are not relevant to exposure conditions for the general public, and most regulatory agencies have not established inhalation limits for propylene glycol, citing lack of data. Read More

View Article and Full-Text PDF

C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo.

BMC Microbiol 2022 May 12;22(1):128. Epub 2022 May 12.

Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Haidian District, 12 Zhongguancun Nandajie St, Beijing, 100081, People's Republic of China.

Background: Enteropathogenic Escherichia coli and Salmonella pullorum are two important groups of zoonotic pathogens. At present, the treatment of intestinal pathogenic bacteria infection mainly relies on antibiotics, which directly inhibit or kill the pathogenic bacteria. However, due to long-term irrational, excessive use or abuse, bacteria have developed different degrees of drug resistance. Read More

View Article and Full-Text PDF

Modulation of the Drosophila transcriptome by developmental exposure to alcohol.

BMC Genomics 2022 May 6;23(1):347. Epub 2022 May 6.

Center for Human Genetics and Department of Genetics and Biochemistry, Clemson University, 114 Gregor Mendel Circle, Greenwood, SC, 29646, USA.

Background: Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent, preventable pediatric disorder. Identifying genetic risk alleles for FASD is challenging since time, dose, and frequency of exposure are often unknown, and manifestations of FASD are diverse and evident long after exposure. Drosophila melanogaster is an excellent model to study the genetic basis of the effects of developmental alcohol exposure since many individuals of the same genotype can be reared under controlled environmental conditions. Read More

View Article and Full-Text PDF

Cross-linker-free sodium alginate and gelatin hydrogels: a multiscale biomaterial design framework.

J Mater Chem B 2022 May 18;10(19):3614-3623. Epub 2022 May 18.

Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana 502285, India.

Surface functionalization and cross-linking have been adopted extensively by researchers to customize hydrogel properties, especially in the last decade. The clinical translation of such biomaterials is in a poor state due to long-term toxicity, often beyond the periphery of the short-term animal studies. We endeavor to relook at the material development strategy with all FDA-approved biopolymers in their native states, like gelatin and sodium alginate, without using any functionalization and cross-linking. Read More

View Article and Full-Text PDF

The Role of JAK and STAT3 in Regulation of Secretory Function of Neuroglial Cells of Different Types in Ethanol-Induced Neurodegenerationt.

Bull Exp Biol Med 2022 Apr 2;172(6):686-690. Epub 2022 May 2.

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

The effects of JAK and STAT3 inhibitors on the production of neurotrophic growth factors by different types of neuroglial cells were studied under conditions of in vitro and in vivo models of ethanol-induced neurodegeneration. It was shown that these signaling molecules do not participate in the secretion of neurotrophins by intact astrocytes and oligodendrocytes. The inhibitory role of JAK in the regulation of this function of microglial cells was revealed. Read More

View Article and Full-Text PDF

transesterification of single-cell oil for biodiesel production: a review.

Prep Biochem Biotechnol 2022 May 2:1-16. Epub 2022 May 2.

Bioprocess and Bioseparation Laboratory, Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

In recent years, biodiesel synthesis and production demands have increased because of its high degradability, cleaner emissions, non-toxicity, and an alternative to petroleum diesel. In this context, Single Cell Oil (SCO) has been identified as an alternative feedstock, having the advantage of accumulating high intracellular lipid. SCO/microbial lipids are potential alternatives for sustainable biodiesel production. Read More

View Article and Full-Text PDF

Pegylation of phenothiazine - A synthetic route towards potent anticancer drugs.

J Adv Res 2022 03 9;37:279-290. Epub 2021 Jul 9.

Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.

Introduction: Cancer is a big challenge of the 21 century, whose defeat requires efficient antitumor drugs.

Objectives: The paper aims to investigate the synergistic effect of two structural building blocks, phenothiazine and poly(ethylene glycol), towards efficient antitumor drugs.

Methods: Two PEGylated phenothiazine derivatives were synthetized by attaching poly(ethylene glycol) of 550 Da to the nitrogen atom of phenothiazine by ether or ester linkage. Read More

View Article and Full-Text PDF

Ribose conversion with amino acids into pyrraline platform chemicals - expeditious synthesis of diverse pyrrole-fused alkaloid compounds.

RSC Adv 2021 Sep 23;11(50):31511-31525. Epub 2021 Sep 23.

Department of Energy Science and Technology, Department of Chemistry, Myongji University Myongji-Ro 116, Cheoin-Gu Yongin Gyeonggi-Do 17058 Korea

One-pot conversion of sustainable d-ribose with l-amino acid, methyl esters produced pyrrole-2-carbaldehydes 5 in reasonable yields (32-63%) under pressurized conditions of 2.5 atm at 80 °C. The value-added pyrraline compounds 5 as platform chemicals were utilized for quick installation of poly-heterocyclic cores for the development of pyrrole-motif natural and artificial therapeutic agents. Read More

View Article and Full-Text PDF
September 2021

Metabolomics-Driven Identification of the Rate-Limiting Steps in 1-Propanol Production.

Front Microbiol 2022 14;13:871624. Epub 2022 Apr 14.

Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Japan.

The concerted effort for bioproduction of higher alcohols and other commodity chemicals has yielded a consortium of metabolic engineering techniques to identify targets to enhance performance of engineered microbial strains. Here, we demonstrate the use of metabolomics as a tool to systematically identify targets for improved production phenotypes in . Gas chromatography/mass spectrometry (GC/MS) and ion-pair LC-MS/MS were performed to investigate metabolic perturbations in various 1-propanol producing strains. Read More

View Article and Full-Text PDF

Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance.

AAPS PharmSciTech 2022 Apr 29;23(5):130. Epub 2022 Apr 29.

Department of Pharmacy, Anhui University of Chinese Medicine, No. 350, Longzihu Road, Hefei, Anhui, 230012, People's Republic of China.

Multidrug resistance (MDR) is a key determinant for hepatocellular carcinoma chemotherapy failure. P-glycoprotein is one of the main causes of MDR by causing drug efflux in tumor cells. In order to solve this thorny problem, we prepared a sorafenib-loaded polylactic acid-glycolic acid (PLGA) - D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoparticles (SPTNs). Read More

View Article and Full-Text PDF

GC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark.

Sci Rep 2022 Apr 29;12(1):7044. Epub 2022 Apr 29.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), 111 Geonjae-ro, Naju-si, Jeollanam-do, 58245, Republic of Korea.

Osteoporosis affects millions of people worldwide. As such, this study assessed the macrophage-dependent in vitro anti-osteoporosis, phytochemical profile and hepatotoxicity effects in zebrafish larvae of the stem bark extracts of P. africana. Read More

View Article and Full-Text PDF

Effects of early florfenicol exposure on glutathione signaling pathway and PPAR signaling pathway in chick liver.

Ecotoxicol Environ Saf 2022 Jun 26;237:113529. Epub 2022 Apr 26.

College of Traditional Chinese Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China; Hebei Provincial Veterinary Biotechnology Innovation Center, Baoding 071001, China. Electronic address:

Florfenicol (FFC) is a common antibiotic for animals. The nonstandard and excessive use of FFC can cause veterinary drug residues in animals, pollute soil and marine environment, and even threaten human health. Therefore, it is necessary to study the toxicity and side effects of FFC on animals. Read More

View Article and Full-Text PDF

High Biocompatible Poly(lactic-co-glycolic acid)-Based Nanosensitizer With Magnetic Resonance Imaging Capacity for Tumor Targeted Microwave Hyperthermia and Chemotherapy.

J Biomed Nanotechnol 2022 Feb;18(2):369-380

Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, P. R. China.

Microwave (MW) hyperthermia has been widely studied in tumor therapy, while the lack of specificity, and the potential toxicity induced by instability or difficulty in degradation of existed MW thermal sensitizers still limits the application. Herein, a new biocompatible Poly(lactic-co-glycolic acid) (PLGA)-based nanosensitizer of [email protected] (DGPPT) with capacities of magnetic resonance (MR) imaging and mitochondrial targeting for MW hyperthermia combined with chemotherapy was constructed via a double emulsion solvent evaporation method. The modified TPP significantly enhanced the specificity of sensitizer for targeting mitochondria, a heat-sensitive energy supply plant in cells. Read More

View Article and Full-Text PDF
February 2022

Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis.

Cell Mol Life Sci 2022 Apr 28;79(5):265. Epub 2022 Apr 28.

Department of Medicine, University of Szeged, Szeged, 6720, Hungary.

Alcoholic pancreatitis and hepatitis are frequent, potentially lethal diseases with limited treatment options. Our previous study reported that the expression of CFTR Cl channel is impaired by ethanol in pancreatic ductal cells leading to more severe alcohol-induced pancreatitis. In addition to determining epithelial ion secretion, CFTR has multiple interactions with other proteins, which may influence intracellular Ca signaling. Read More

View Article and Full-Text PDF

Pyrene-polyethylene glycol-modified multi-walled carbon nanotubes: Genotoxicity in V79-4 fibroblast cells.

Mutat Res Genet Toxicol Environ Mutagen 2022 Apr-May;876-877:503463. Epub 2022 Feb 11.

ToxLab, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia - Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

The genotoxicity of pyrene-polyethylene glycol-modified multi-walled carbon nanotubes (MWCNT-PyPEG), engineered as a nanoplatform for bioapplication, was evaluated. Toxicity was assessed in hamster lung fibroblast cells (V79-4). MTT and Cell Titer Blue methods were used to evaluate cell viability. Read More

View Article and Full-Text PDF

Potent mutagenicity of an azide, 3-azido-1,2-propanediol, in human TK6 cells.

Mutat Res Genet Toxicol Environ Mutagen 2022 Apr-May;876-877:503475. Epub 2022 Feb 19.

Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan.

Sodium azide is a strong mutagen that has been successfully employed in mutation breeding of crop plants. In biological systems, it is metabolically converted to the proximate mutagen azidoalanine, which requires further bioactivation to a putative ultimate mutagen that remains elusive. The nature of the DNA modifications induced by azides leading to mutations is also unknown. Read More

View Article and Full-Text PDF

Caffeic acid dimethyl ether alleviates alcohol-induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway.

Bioengineered 2022 Apr;13(4):11122-11136

College of Pharmacy, Guilin Medical University, Guilin, China.

Alcoholic liver disease (ALD), with its increasing morbidity and mortality, has seriously and extensively affected the health of people worldwide. Caffeic Acid Dimethyl Ether (CADE) significantly inhibits alcohol-induced hepatic steatosis through AMP-activated protein kinase (AMPK) pathway, but its in-depth mechanism remains unclear. This work aimed to clarify further mechanism of CADE in improving hepatic lipid accumulation in ALD through the microRNA-378b (miR-378b)-mediated Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-AMPK signaling pathway. Read More

View Article and Full-Text PDF

The Heck reaction of allylic alcohols catalysed by an N-heterocyclic carbene-Pd(ii) complex and toxicity of the ligand precursor for the marine benthic copepod .

RSC Adv 2021 Jun 7;11(33):20278-20284. Epub 2021 Jun 7.

Instituto de Química Aplicada, Universidad del Papaloapan Tuxtepec Oaxaca 68301 México

The palladium-catalysed reaction of aryl halides and allylic alcohols is an attractive method for obtaining α,β-unsaturated aldehydes and ketones, which represent key intermediates in organic synthesis. In this context, a 1,2,3-triazol-5-ylidene (aNHC)-based palladium(ii) complex formed has been found to be a selective catalyst for the syntheses of building blocks from the corresponding aryl halides and allylic alcohols, with yields ranging from 50% to 90%. The lack of toxic effects of the ligand precursor (1,2,3-triazolium salt) of the palladium(ii) complex for the harpacticoid copepod allowed us to contrast the efficiency of the catalytic system with the potential impact of the principal waste chemical in global aquatic ecosystems, which has not been previously addressed. Read More

View Article and Full-Text PDF

DDQ as a versatile and easily recyclable oxidant: a systematic review.

RSC Adv 2021 Sep 8;11(47):29826-29858. Epub 2021 Sep 8.

Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University 21955 Makkah Saudi Arabia

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) is the most widely used quinone with a high reduction potential, and it commonly mediates hydride transfer reactions and shows three accessible oxidation states: quinone (oxidized), semiquinone (one-electron-reduced), and hydroquinone (two-electron-reduced). DDQ has found broad utility as a stoichiometric oxidant in the functionalization of activated C-H bonds and the dehydrogenation of saturated C-C, C-O, and C-N bonds. The cost and toxicity of DDQ triggered recent efforts to develop methods that employ catalytic quantities of DDQ in combination with alternative stoichiometric oxidants. Read More

View Article and Full-Text PDF
September 2021

PEGylated Domain I of Beta-2-Glycoprotein I Inhibits Thrombosis in a Chronic Mouse Model of the Antiphospholipid Syndrome.

Front Immunol 2022 11;13:842923. Epub 2022 Apr 11.

Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom.

Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical effects of vascular thrombosis and pregnancy morbidity. The only evidence-based treatments are anticoagulant medications such as warfarin and heparin. These medications have a number of disadvantages, notably risk of haemorrhage. Read More

View Article and Full-Text PDF

Hypoxia-Responsive Stereocomplex Polymeric Micelles with Improved Drug Loading Inhibit Breast Cancer Metastasis in an Orthotopic Murine Model.

ACS Appl Mater Interfaces 2022 May 27;14(18):20551-20565. Epub 2022 Apr 27.

Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226019, People's Republic of China.

Tumor metastasis is a leading cause of breast cancer-related death. Taxane-loaded polymeric formulations, such as Genexol PM and Nanoxel M using poly(ethylene glycol)-poly(d,l-lactide) (PEG-PLA) micelles as drug carriers, have been approved for the treatment of metastatic breast cancer. Unfortunately, the physical instability of PEG-PLA micelles, leading to poor drug loading, premature drug leakage, and consequently limited drug delivery to tumors, largely hinders their therapeutic outcome. Read More

View Article and Full-Text PDF