Pediatr Dent 2021 Mar;43(2):88-94
Dr. Divaris is a professor, Division of Pediatric and Public Health, Adams School of Dentistry, all at the University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA.
Buffered local anesthetics offer an alternative to conventional, unbuffered anesthetic formulations; however, evidence about their use in children is scant. The purpose of this study was to determine the anesthetic and physiologic differences associated with the use of buffered one percent and unbuffered two percent lidocaine (both with 1:100,000 epinephrine) in children. In this randomized, double-blinded, crossover study, 25 children ages 10 to 12 years old received two inferior alveolar never blocks, at least one week apart, randomized to alternating sequences of two drug formulations: (1) formula A-three mL buffered one percent lidocaine (i. Read More