4,486 results match your criteria Toxicity Acetaminophen


Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion.

Phytomedicine 2021 Apr 24;87:153579. Epub 2021 Apr 24.

State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China; Key Laboratory of Herbage & Endemic Crop Biology of Ministry of Education, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China. Electronic address:

Background: Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effects. However, little is known about the bioactivities of other chemical constituents in Safflower and the relationship between enhancement of blood circulation and hepatoprotection by HSYA.

Purpose: The present research was to evaluate the antithrombotic and hepatoprotective activities of HSYA and C, examine their mechanisms of actions, including influence on the excretion velocity of acetaminophen, and the relationship between the antithrombotic, hepatoprotective, and other bioactivities. Read More

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Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.

Nat Commun 2021 May 11;12(1):2621. Epub 2021 May 11.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Cullin-RING E3 ligases (CRLs) regulate the turnover of approximately 20% of mammalian cellular proteins. Neddylation of individual cullin proteins is essential for the activation of each CRL. We report herein the discovery of DI-1548 and DI-1859 as two potent, selective and covalent DCN1 inhibitors. Read More

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Successful treatment of amiodarone-induced hepatic injury with n-acetylcysteine: A case report.

Indian J Pharmacol 2021 Jan-Feb;53(1):60-62

Department of Cardiology, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey.

Intravenous amiodarone treatment may cause hepatic toxicity. N-acetylcysteine (NAC) is a powerful antioxidant, reduces the level of free radicals by increasing glutathione levels, and is used in acetaminophen intoxication. An 83-year-old female Caucasian patient who had congestive heart failure and implantable cardioverter-defibrillator was admitted to the hospital with palpitations and confusion. Read More

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Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.

Toxicology 2021 May 7:152811. Epub 2021 May 7.

Department of Medicine, USA; Marion Bessin Liver Research Center, USA; Department of Pathology, USA; Diabetes Center, USA; Fleischer Institute for Diabetes and Metabolism, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:

Preterm infants are at greater risk for adverse drug effects due to hepatic immaturity. Multiple interventions during intensive care increases potential for drug interactions. In this setting, high-dose caffeine used for apnea in premature infants may increase acetaminophen toxicity by inhibiting ataxia telangiectasia mutated (ATM) gene activity during DNA damage response. Read More

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HEPATOPROTECTIVE EFFICIENCY OF G10 SUBSTANCE FROM ZHUZGUN PLANT IN EXPERIMENTAL TOXIC HEPATITIS.

Georgian Med News 2021 Mar(312):138-145

NJCC"Astana Medical University", Department of General Pharmacology, Nur-Sultan, Kazakhstan.

The article presents the results of biochemical studies of blood and morphological characteristics of liver changes in laboratory animals (rats) under experimental conditions of paracetamol hepatitis and intragastric administration of a new substance G10 from the «Zhuzgun» plant in various doses. The obtained data open up prospects for further studies of the pharmacological properties of the substance G10, the possibility of including it as a phytotherapeutic agent in the complex of preventive and therapeutic measures for acute toxic hepatitis. The study of the hepatoprotective properties was conducted in the "Educational and Research Pharmacological Laboratory" of the Department of General Pharmacology of the Astana Medical University. Read More

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Analysis of the Australia and New Zealand referral criteria for transfer to a liver unit for paracetamol overdose.

Emerg Med Australas 2021 May 4. Epub 2021 May 4.

Department of Critical Care, The University of Melbourne, Melbourne, Victoria, Australia.

Objectives: Paracetamol overdose is common and can lead to fulminant hepatic failure. In cases that are not improving with standard medical therapy with N-acetylcysteine, some patients may require liver transplant. The Australia and New Zealand (ANZ) referral criteria for transfer to a liver unit have not been extensively studied for its predictive value. Read More

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Incidence and profile of acute intoxication among adult population in Najran, Saudi Arabia: A retrospective study.

Sci Prog 2021 Apr-Jun;104(2):368504211011339

Regional Laboratory, Ministry of Health, Najran, Saudi Arabia.

Acute poisoning is considered one of the most important medical emergencies, resulting in severe morbidity and mortality, and is an economic burden on governments. This study aimed to determine the extent of acute adult intoxication among the population located in the Najran area, Saudi Arabia, over the last 3 years (from January 2017 to December 2019). The study is a hospital-based retrospective observational study. Read More

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[Research progress on hepatotoxicity of acetaminophen].

Authors:
T Hu W Q Huang H Sun

Zhonghua Gan Zang Bing Za Zhi 2021 Mar;29(3):279-283

Institute of Viral Hepatitis, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Acetaminophen (APAP) is a widely used antipyretic and analgesic drug that is safe and effective in the therapeutic doses, but overdose may cause hepatotoxicity and even acute liver failure (ALF). Finding reliable biomarkers for APAP toxicity is not only a hot spot of current research, but also a problem that needs to be solved urgently. Clinicians should consider the existence of APAP hepatotoxicity when using APAP treatment, and explain that APAP may have a certain degree of dose dependence. Read More

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Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity.

Psychiatr Serv 2021 Apr 23:appips202000081. Epub 2021 Apr 23.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota (Shekunov, Vande Voort, Bostwick, Romanowicz); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Lewis).

Objective: Acetaminophen is a common cause of intentional and inadvertent overdoses among children and adolescents worldwide. Little is known about characteristics and clinical outcomes of these youths. The primary goal of this naturalistic study was to describe the psychiatric characteristics, medical management, outcomes, and dispositions of children and adolescents evaluated for excessive acetaminophen exposure. Read More

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Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used?

J Med Toxicol 2021 Apr 21. Epub 2021 Apr 21.

Kentucky Poison Control Center, Norton Children's Hospital, PO Box 35070, Louisville, KY, 40232-5070, USA.

Introduction: Acetaminophen is a commonly used analgesic and antipyretic, with the potential to cause significant injury when ingested in toxic amounts. Although the antidote n-acetylcysteine (NAC) is available, evidence supporting dose recommendations for patients weighing over 100 kg are lacking. We performed a retrospective, multi-center analysis to determine if a capped NAC dosing scheme is similar to a non-capped dosing scheme in patients weighing over 100 kg. Read More

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Continuous Venovenous Hemofiltration as a Rescue Therapy for Severe Acetaminophen Toxicity in a Toddler.

J Pediatr Intensive Care 2021 Jun 22;10(2):159-161. Epub 2020 May 22.

Division of Pediatric Critical Care, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Acetaminophen poisoning is one of the common accidental poisoning in children. Accidental administration of mismatched doses of drops for syrups can lead to life-threatening overdose. N-acetylcysteine (NAC) is the specific antidote; however, extracorporeal therapy such as continuous venovenous hemofiltration (CVVH) can be used as a rescue measure when there is no improvement despite adequate NAC therapy and can be lifesaving. Read More

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Can granulocyte colony stimulating factor (G-CSF) ameliorate acetaminophen-induced hepatotoxicity?

Hum Exp Toxicol 2021 Apr 22:9603271211008522. Epub 2021 Apr 22.

Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, 68796Assiut University, Assiut, Egypt.

Acetaminophen (APAP) is often used as an antipyretic and analgesic agent. Overdose hepatotoxicity, which often results in liver cell failure and liver transplantation, is a severe complication of APAP usage. To save the liver and save lives from acute liver damage caused by APAP, the search for new strategies for liver defense is important. Read More

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Use of ibuprofen for the closure of patent ductus arteriosus in preterm infants: a systematic review of meta-analyses.

J Comp Eff Res 2021 May 21;10(7):549-568. Epub 2021 Apr 21.

College of Pharmacy, QU Health, Qatar University, Doha, Qatar.

To systematically review ibuprofen, including versus indomethacin and paracetamol/acetaminophen, for the closure of patent ductus arteriosus (PDA). Pubmed, Embase, Cochrane and gray literature were searched to summarize ibuprofen outcomes in closure of PDA in published meta-analyses (MAs). Seven MAs were included. Read More

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Hepatoprotective potential of kirenol on ethanol-induced liver toxicity in albino rats and acetaminophen-induced oxidative stress-mediated apoptosis in hepatic HepG2 cells.

J Biochem Mol Toxicol 2021 Apr 12:e22786. Epub 2021 Apr 12.

Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.

Liver diseases are a major health issue in both men and women and cause significant mortality worldwide. The hepatoprotective effects of kirenol were evaluated in acetaminophen (APAP)-induced toxicity in HepG2 cells and ethanol (EtOH)- induced hepatotoxicity in rats. The cytotoxicity of kirenol (IC , 25 µM/ml) and APAP (20 µg/ml) with sylimarin (IC , 15 µg/ml) was observed in HepG2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Read More

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Routine Laboratory Screening for Acetaminophen and Salicylate Ingestion in Preadmission Psychiatric Patients Is Unnecessary.

Ann Emerg Med 2021 Apr 8. Epub 2021 Apr 8.

Zablocki Veterans Administration Medical Center, Milwaukee, WI.

Study Objective: Screening preadmission psychiatric patients for acetaminophen or salicylate overdose is unnecessary in the absence of specific clinical concern for medication ingestion.

Methods: This was a multicenter retrospective cohort study of 3 Veteran's Administration emergency departments that medically evaluate patients prior to psychiatric admission. During the 10-year study period, these departments followed screening protocols that required the measurement of acetaminophen and salicylate levels on every patient prior to psychiatric admission. Read More

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Malnourishment-Associated Acetaminophen Toxicity in Pregnancy.

Obstet Gynecol 2021 05;137(5):877-880

Department of Obstetrics and Gynecology, University of Rochester Medical Center, the University of Rochester School of Medicine and Dentistry, and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York.

Background: Although acetaminophen is commonly used in pregnancy, it can deplete glutathione concentrations and cause accumulation of 5-oxoproline, with subsequent metabolic acidosis.

Case: A malnourished 25-year-old woman, G2P1001, with chronic acetaminophen use presented with abdominal pain and high anion gap metabolic acidosis. After ruling out other potential causes, her urine 5-oxoproline level was found to be elevated. Read More

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Toxicity reduction of persistent pollutants through the photo-fenton process and radiation/HO using different sources of radiation and neutral pH.

J Environ Manage 2021 Jul 1;289:112500. Epub 2021 Apr 1.

State University of Maringa, Department of Chemical Engineering, Maringa, 87020-900, Parana, Brazil.

The presence of toxic compounds in aquatic bodies is of great concern, and the Fenton, photo-Fenton and radiation/HO processes can be applied in the remediation of these compounds due to their efficiency and advantages. However, these processes need to be investigated to make them more viable and environmentally friendly. Thus, the reduction of toxicity was evaluated, through ecotoxicological tests with Artemia salina and Lactuca sativa, of the compounds 2,4-D, diazepam, nicotine and paracetamol (acetaminophen) by the Fenton, photo-Fenton and radiation/HO process with UVC, UVA and natural solar radiation at neutral pH with low concentrations of Fe and HO. Read More

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Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells.

Toxicol In Vitro 2021 Aug 31;74:105156. Epub 2021 Mar 31.

Department of Chemistry, University of North Carolina at Chapel Hill, Kenan and Caudill Laboratories, Chapel Hill, NC 27599-3290, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599-7295, United States of America. Electronic address:

This study evaluates the impact of physiologically relevant oxygen tensions on the response of HepG2 cells to known inducers and hepatotoxic drugs. We compared transcriptional regulation and CYP1A activity after a 48 h exposure at atmospheric culture conditions (20% O) with representative periportal (8% O) and perivenous (3% O) oxygen tensions. We evaluated cellular responses in 2D and 3D cultures at each oxygen tension in parallel, using monolayers and a paper-based culture platform that supports cells suspended in a collagen-rich environment. Read More

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N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice.

Antioxidants (Basel) 2021 Mar 12;10(3). Epub 2021 Mar 12.

Department of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Jianguo N. Road, Taichung 40201, Taiwan.

Acetaminophen (APAP) overdose induces acute liver damage and even death. The standard therapeutic dose of N-acetyl cysteine (NAC) cannot be applied to every patient, especially those with high-dose APAP poisoning. There is insufficient evidence to prove that increasing NAC dose can treat patients who failed in standard treatment. Read More

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The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury.

Int J Mol Sci 2021 Mar 8;22(5). Epub 2021 Mar 8.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

Hypoxia-induced mitogenic factor (HIMF), which is also known as resistin-like molecule α (RELM-α), found in inflammatory zone 1 (FIZZ1), or resistin-like alpha (retlna), is a cysteine-rich secretory protein and cytokine. HIMF has been investigated in the lung as a mediator of pulmonary fibrosis, inflammation and as a marker for alternatively activated macrophages. Although these macrophages have been found to have a role in acute liver injury and acetaminophen toxicity, few studies have investigated the role of HIMF in acute or immune-mediated liver injury. Read More

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Deranged liver function in pregnancy.

BMJ 2021 03 31;372:n645. Epub 2021 Mar 31.

Guy's and St Thomas' Hospital NHS Trust, St Thomas' Hospital, London, UK.

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A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity.

Authors:
Lorena Bavia

J Pharmacol Toxicol Methods 2021 Mar-Apr;108:106960. Epub 2021 Mar 22.

Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:

Acetaminophen (APAP) is commonly used to treat fever and pain. However, when in overdose is the predominant cause of hepatotoxicity. Despite advances in understanding the mechanisms of APAP-induced hepatotoxicity, the management of acute liver failure remains a challenge. Read More

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The developing murine lung is susceptible to acetaminophen toxicity.

Am J Physiol Lung Cell Mol Physiol 2021 Mar 24. Epub 2021 Mar 24.

Pediatrics, University of Colorado Anschutz Medical Campus, United States.

Acetaminophen (N-acetyl-p-aminophenol, APAP) use in the neonatal intensive care unit is rapidly increasing. While APAP-related hepatotoxicity is rarely reported in the neonatal literature, other end-organ toxicity can occur with toxic exposures. APAP-induced lung injury has been reported with toxic exposures in adults, but whether this occurs in the developing lung is unknown. Read More

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Role of Non-coding RNA in Acetaminophen-induced Liver Injury.

Gene Expr 2021 Mar 23. Epub 2021 Mar 23.

Ohio State University.

Genomic and transcriptomic analyses have well established that the major fraction of the mammalian genome is transcribed into different classes of RNAs ranging in size from a few nucleotides to hundreds of thousands of nucleotides, which do not encode any protein. Some of these non-coding RNAs (ncRNAs) are directly or indirectly linked to the regulation of expression or functions of ~25,000 proteins coded by <2% of the human genome. Among these regulatory RNAs, microRNAs are small (21-25 nucleotide) RNAs that are processed from precursor RNAs that have stem-loop structure, whereas non-coding RNAs >200 nucleotides are termed lncRNAs (long ncRNAs). Read More

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Opioid therapy vs. multimodal analgesia in head and neck Cancer (OPTIMAL-HN): study protocol for a randomized clinical trial.

BMC Palliat Care 2021 Mar 19;20(1):45. Epub 2021 Mar 19.

Department of Radiation Oncology, London Health Sciences Centre, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.

Background: Radiation-induced mucositis (RIM) pain confers substantial morbidity for head and neck cancer (HNC) patients undergoing radiotherapy alone (RT) or chemoradiotherapy (CRT), often reducing treatment compliance. However, no standard currently exists for the treatment of RIM, and high dose opioid therapy, with its associated side effects and increased risk for chronic opioid use, remains the cornerstone of HNC pain management. The goal of this randomized clinical trial is to compare multimodal analgesia using analgesic medications with different mechanisms of action, to the institutional standard of opioid analgesia alone, in order to ascertain the optimal analgesic regimen for the management of RIM pain in HNC patients. Read More

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Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?

Expert Opin Pharmacother 2021 Mar 10. Epub 2021 Mar 10.

Paolo Procacci Foundation, Via Tacito 7, 00193, Rome, Italy.

Introduction: Opioid analgesia for acute painful conditions has come under increasing scrutiny with the public health crisis of opioid overdose, leading clinicians to seek nonopioid alternatives, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol).

Areas Covered: This perspective evaluates recent clinical trials of nonopioids, opioids, and combination therapy for use in acute pain. Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) often provide adequate analgesia, although these agents are not without risks. Read More

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Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways.

FASEB J 2021 Apr;35(4):e21471

Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Acute liver failure constitutes a devastating condition that needs novel cell and molecular therapies. To elicit synergisms in cell types of therapeutic interest, we studied hepatocytes and liver sinusoidal endothelial in mice with acetaminophen-induced acute liver failure. The context of regenerative signals was examined by transplants in peritoneal cavity because it possesses considerable capacity and allows soluble signals to enter the systemic circulation. Read More

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FXR-Deoxycholic Acid-TNFα Axis Modulates Acetaminophen-Induced Hepatotoxicity.

Toxicol Sci 2021 Feb 28. Epub 2021 Feb 28.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892.

The idiosyncratic characteristics and severity of acetaminophen (APAP) overdose-induced hepatotoxicity render identifying the predisposing factors and mechanisms of APAP-induced liver toxicity necessary and urgent. Farnesoid X receptor (FXR) controls bile acid homeostasis and modulates the progression of various liver diseases. While global FXR deficiency in mice enhances APAP intoxication, the mechanism remains elusive. Read More

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February 2021

Early closure mechanisms of the ductus arteriosus in immature infants.

Acta Paediatr 2021 Mar 2. Epub 2021 Mar 2.

Department of Neonatology, Nantes University Hospital, Nantes, France.

Aim: According to experimental studies, cardiopulmonary distress decreases after closure of patent ductus arteriosus. However, early closure of the ductus using ibuprofen or indomethacin has failed to increase survival without serious morbidity. We review relevant data aiming to define optimal early management strategies that promote early closure of ductus arteriosus without serious adverse effects. Read More

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