42,256 results match your criteria Toxic Shock Syndrome

Ketamine; history and role in anesthetic pharmacology.

Neuropharmacology 2022 Jun 25:109171. Epub 2022 Jun 25.

Department of Cardiovascular Sciences (Anaesthesia, Critical Care and Pain Management), University of Leicester, Hodgkin Building, Leicester, LE1 9HN, UK.

Ketamine (Ket) was developed in 1962 as a less hallucinogenic and shorter acting agent than phencyclidine. It was given to humans for the first time in 1964. However, Ket produces several adverse reactions such as raised intracranial and blood pressures along with seizures, and patients still show low acceptance due to hallucinations. Read More

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Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials.

J Crit Care 2022 Jun 25;71:154099. Epub 2022 Jun 25.

Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil; Oxford-Brazil EBM Alliance, Brazil; Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.

Purpose: to critically appraise and synthesize the evidence on the effects of vitamin C-based regimens for patients with sepsis or septic shock.

Methods: a broad search was performed on May 2021 to identify randomized clinical trials (RCTs) assessing vitamin C-based regimens as adjuvant therapy for adults with sepsis or septic shock. We used the Cochrane Risk of Bias table to assess the methodological quality of the included RCTs and the GRADE approach to evaluate the evidence certainty. Read More

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Clinical and sociodemographic characterization of pregnant women hospitalized with COVID-19.

Gac Med Mex 2022 ;158(2):69-77

Institute of Health Sciences, Universidad Veracruzana.

Introduction: In pregnant women, a higher risk for developing viral respiratory infections is identified.

Objective: To analyze sociodemographic characteristics, evolution, clinical manifestations, and complications of pregnant women hospitalized with COVID-19.

Methods: Study conducted at 11 public hospitals; sociodemographic variables, comorbidities, signs and symptoms, laboratory and imaging findings, pregnancy characteristics, treatment and pregnancy outcome were included for analysis. Read More

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January 2022

The impact of hypoalbuminemia on postoperative outcomes after outpatient surgery: a national analysis of the NSQIP database.

Can J Anaesth 2022 Jun 27. Epub 2022 Jun 27.

Department of Anesthesiology, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Davol #129, Providence, RI, 02903, USA.

Purpose: Hypoalbuminemia has been described as a modifiable factor to optimize postoperative outcomes after major inpatient surgeries. Nevertheless, the role of hypoalbuminemia on outpatient procedures is not well defined. The purpose of this study was to examine the impact of hypoalbuminemia on postoperative outcomes of patients undergoing low-risk outpatient surgery. Read More

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Septic shock caused by Capnocytophaga canimorsus in a patient with heterozygous Pelger-Huët anomaly.

Int J Hematol 2022 Jun 27. Epub 2022 Jun 27.

Hematology Service. University Son Llàtzer Hospital, Palma, Spain.

Capnocytophaga canimorsus is a Gram-negative bacillus of the commensal flora of dogs and cats that can cause infections in humans through bites, scratches or contact with oral secretions. It can be difficult to identify in clinical microbiology laboratories because of the need for specific culture media. We present the case of a patient with no relevant medical history who was admitted with septic shock, where blood smear examination was crucial for the etiologic diagnosis of Capnocytophaga canimorsus infection. Read More

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Selepressin in Septic Shock.

Shock 2022 Jun;57(6):172-179

Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.

Abstract: Sepsis and septic shock usually show a high mortality rate and frequently need of intensive care unit admissions. After fluid resuscitation, norepinephrine (NE) is the first-choice vasopressor in septic shock patients. However, high-NE doses are associated with increased rates of adverse effects and mortality. Read More

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Changes in the Genotypic Characteristics of Community-Acquired Methicillin-Resistant Staphylococcus aureus Collected in 244 Medical Facilities in Japan between 2010 and 2018: a Nationwide Surveillance.

Microbiol Spectr 2022 Jun 27:e0227221. Epub 2022 Jun 27.

Toho University, Tokyo, Japan.

Although community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged worldwide, no nationwide CA-MRSA surveillance has been conducted in Japan to determine the changes in its molecular characteristics over time. We aimed to characterize the molecular epidemiology of Panton-Valentine leucocidin (PVL)-positive CA-MRSA strains collected from across Japan in the past decade. We isolated 1,770 MRSA strains from the skin and pus samples of outpatients of 244 medical facilities in 31 prefectures between 2010 and 2018 (2010, 2012, 2014, 2016, and 2018). Read More

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A nationwide study on characteristics and outcome of cancer patients with sepsis requiring intensive care.

Acta Oncol 2022 Jun 26:1-9. Epub 2022 Jun 26.

Department of Anaesthesia and Intensive Care, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

Background: Sepsis is the leading cause of admission to the intensive care unit (ICU) for cancer patients and survival rates have historically been low. The aims of this nationwide cohort study were to describe the characteristics and outcomes of cancer patients admitted to the ICU with sepsis compared with other sepsis patients requiring ICU admission.

Material And Methods: This was a retrospective, observational study. Read More

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Natural and genetically-modified animal models to investigate pulmonary and extrapulmonary manifestations of COVID-19.

Int Rev Immunol 2022 Jun 25:1-20. Epub 2022 Jun 25.

Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, India.

Coronavirus disease-19 (COVID-19), a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a primarily respiratory tract disease. Suitable animal models for COVID-19 are required to study various aspects of pathogenesis, drug discovery, effective and safe vaccine development. Several laboratory animals including, non-human primates, hamsters, ferrets, transgenic mice, and zebrafish, have been used and proven their significance experimentally. Read More

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Mortality-associated clinical risk factors in patients with febrile neutropenia: A retrospective study.

IJID Reg 2021 Dec 20;1:5-11. Epub 2021 Sep 20.

Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Objectives: To determine the predictors for 30-day all-cause mortality in patients with febrile neutropenia (FN) and develop a prediction score.

Methods: The electronic medical records of patients undergoing chemotherapy with FN between 2018 and 2019 were reviewed. Multivariate logistic regression was performed to identify factors associated with 30-day all-cause mortality to develop a parsimonious model. Read More

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December 2021

Neutrophil Extracellular Traps, Sepsis and COVID-19 - A Tripod Stand.

Front Immunol 2022 10;13:902206. Epub 2022 Jun 10.

Department of Biology, State University of New York at Fredonia, Fredonia, NY, United States.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Majority of COVID-19 patients have mild disease but about 20% of COVID-19 patients progress to severe disease. These patients end up in the intensive care unit (ICU) with clinical manifestations of acute respiratory distress syndrome (ARDS) and sepsis. Read More

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First Reported Australian case of Fatal Streptococcal Group B Pneumonia (serotype 21) Necrotising fasciitis complicated by Toxic Shock Like Syndrome - A Case report and review.

IJID Reg 2022 Mar 13;2:165-168. Epub 2022 Jan 13.

Critical Care Department, Goulburn Valley Health, Graham Street Campus, Shepparton, Victoria, Australia.

Introduction: NF is a life-threatening infection and progressive disease resulting in widespread fulminant tissue destruction. It is rarely caused by Group B Streptococcus pneumonia. Early management with surgical removal of devitalized tissue and urgent antibiotic administration are key therapies. Read More

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Impact of a Mental Health Diagnosis on Emergency Department Adherence to Sepsis Care Guidelines.

Ochsner J 2022 ;22(2):134-138

Department of Emergency Medicine, Louisiana State University Health Sciences Center, Baton Rouge, LA.

Previous work has found that clinical care for a variety of health conditions varies depending upon the mental health status of the patient. Sepsis, a condition with an algorithm-driven care plan, has not yet been investigated. This study sought to determine if disparities in care exist for people with mental illness and suspected sepsis. Read More

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January 2022

A double-J stent misguided by zebra guidewire into ileum: A case report and literature review.

Urol Case Rep 2022 Sep 10;44:102128. Epub 2022 Jun 10.

Department of Urology, People's Hospital of Leshan, 238 BaitaStreet, Leshan, 614000, Sichuan Province, PR China.

The case is a 70-year-old man who underwent a left nephroureterectomy and cutaneous ureterostomy on the contralateral side for invasive bladder cancer had to be accepted replacement of the double-J stent because of stomal stenosis.When replacing the double-J stent, a severe complication that the double-J stent misguided into the ileum occurred. The patient underwent gastrointestinal motility drugs, and the double-J stent was excreted with the feces after 12 hours. Read More

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September 2022

Early recovery status and outcomes after sepsis-associated acute kidney injury in critically ill patients.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):535-545

Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011.

Objectives: Acute kidney injury (AKI) is one of the common complications in critically ill septic patients, which is associated with increased risks of death, cardiovascular events, and chronic renal dysfunction. The duration of AKI and the renal function recovery status after AKI onset can affect the patient prognosis. Nevertheless, it remains controversial whether early recovery status after AKI is closely related to the prognosis in patients with sepsis-associated AKI (SA-AKI). Read More

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Red cell distribution width and in-hospital mortality in septic shock: A public database research.

Int J Lab Hematol 2022 Jun 24. Epub 2022 Jun 24.

Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Objective: This study aimed to explore the relationship between red cell distribution width (RDW) and in-hospital mortality in septic shock based on a large-scale public database.

Methods: All patients with septic shock in MIMIC-IV were enrolled. Based on RDW values, the general characteristics of different groups were compared. Read More

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Machine learning decision support model for radical cystectomy discharge planning.

Urol Oncol 2022 Jun 21. Epub 2022 Jun 21.

Memorial Sloan Kettering Cancer Center, Department of Surgery, Urology Service, New York, NY. Electronic address:

Purpose: Timely and appropriate discharge placement for patients who have undergone radical cystectomy (RC) remains challenging. Our objective was to improve the discharge planning process by creating a machine learning model that helps to predict the need for non-home hospital discharge to a higher level of care.

Materials And Methods: Patients undergoing elective radical cystectomy for bladder cancer from 2014-2019 were identified in the ACS-NSQIP database. Read More

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Patient Care Alterations After Point-of-Care Laboratory Testing During Critical Care Transport.

Air Med J 2022 Jul-Aug;41(4):370-375. Epub 2022 May 23.

Department of General Surgery, Novant Health New Hanover Regional Medical Center, Wilmington, NC.

Objective: Point-of-care laboratory testing (POCT) is associated with a reduced time to testing results and critical decision making within emergency departments. POCT is an essential clinical assessment tool because laboratory data are used to support timely critical decisions regarding acute medical conditions onditions ; however, there is currently limited research to support the use of POCT in the critical care transport environment. Few studies have evaluated the changes in patient care that occur after POCT during critical care transport. Read More

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Safety and risk of febrile recurrence after early antibiotic discontinuation in high-risk neutropenic patients with haematological malignancies: a multicentre observational study.

J Antimicrob Chemother 2022 Jun 24. Epub 2022 Jun 24.

Department of Infectious Diseases, University Hospital of Nantes and CIC 1413, Nantes, France.

Background: Early antibiotic discontinuation according to the Fourth European Conference on Infections in Leukaemia (ECIL-4) recommendations is not systematically applied in high-risk neutropenic patients with haematological malignancies.

Methods: A retrospective multicentre observational study was conducted over 2 years to evaluate the safety of early antibiotic discontinuation for fever of unknown origin (FUO) during neutropenia after induction chemotherapy or HSCT, in comparison with a historical cohort. We used Cox proportional hazards models, censored on neutropenia resolution, to analyse factors associated with febrile recurrence. Read More

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Achromobacter xylosoxidans Bacteremia in a Liver Transplant Patient: A Case Report and Literature Review.

Cureus 2022 Jun 17;14(6):e26048. Epub 2022 Jun 17.

Medicine, Hamad General Hospital, Doha, QAT.

Since the first isolation of Achromobacter xylosoxidans, it has been increasingly recognized as an opportunistic pathogen. It is an aerobic Gram-negative bacillus mainly found in aquatic environments. It has been reported to cause nosocomial infections, especially in immunocompromised patients. Read More

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Does the Same Hyperlactatemia Cut-Off in the Context of Acute Diseases Hold the Same Meaning in Diabetes Mellitus?

Cureus 2022 May 20;14(5):e25163. Epub 2022 May 20.

Internal Medicine, Coimbra Hospital and University Center, Coimbra, PRT.

Background Hyperlactatemia is defined by a lactate concentration of >2 mmol/L, and a lactate concentration of above >4 mmol/L is commonly used to define severe hyperlactatemia. It is a common disorder in critically ill patients and is associated with adverse prognosis. Diabetes mellitus(DM) can also be associated with increased lactate levels at baseline. Read More

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Comparison of Trans-septal Suturing Technique With Polyvinyl Alcohol Sponge-Based Nasal Packing for Hemostasis in Septoplasty.

Cureus 2022 May 20;14(5):e25161. Epub 2022 May 20.

Otolaryngology - Head and Neck Surgery, Maulana Azad Medical College, New Delhi, IND.

Introduction Despite the theoretical advantages of bleeding control, there is increased morbidity in postoperative pain, sleep disturbance, allergy, toxic shock syndrome, and mucosal injury with the nasal packing in septoplasty procedure for deviated nasal septum. Trans-septal suturing after septoplasty has been advocated as an effective alternative to conventional nasal packing. The current study aims to compare the frequency of subjective symptoms, such as postoperative nasal pain, nasal bleeding, postnasal drip, sleep disturbance, dysphagia, headache, and epiphora between the trans-septal suturing technique and nasal packing in septoplasty surgery. Read More

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A Rescue Use of ECPELLA for Sepsis-Induced Cardiogenic Shock Followed by Mitral Valve Replacement.

Medicina (Kaunas) 2022 May 25;58(6). Epub 2022 May 25.

The Second Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.

The use of veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with sepsis-induced cardiogenic shock has been reported, but the clinical implication of the Impella percutaneous axial-flow left ventricular assist device for such patients remains unknown. We had a 37-year-old man with septic shock and severely reduced cardiac function. Veno-arterial ECMO and concomitant Impella CP support ameliorated his end-organ dysfunction and achieved cardiac recovery, whereas severe mitral valve regurgitation due to chordal rupture developed later. Read More

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Effects of the PARP Inhibitor Olaparib on the Response of Human Peripheral Blood Leukocytes to Bacterial Challenge or Oxidative Stress.

Biomolecules 2022 Jun 4;12(6). Epub 2022 Jun 4.

Department of Medicine, Division of Infectious Diseases, Escola Paulista de Medicina, Federal University of São Paulo (EPM/UNIFESP), São Paulo 04023, Brazil.

Prior studies demonstrate the activation of poly-(ADP-ribose) polymerase 1 (PARP1) in various pathophysiological conditions, including sepsis. We have assessed the effect of olaparib, a clinically used PARP1 inhibitor, on the responses of human peripheral blood leukocytes (PBMCs) obtained from healthy volunteers in response to challenging with live bacteria, bacterial lipopolysaccharide (LPS), or oxidative stress (hydrogen peroxide, HO). The viability of PBMCs exposed to olaparib or to the earlier generation PARP inhibitor PJ-34 (0. Read More

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Comparison of Transcriptional Signatures of Three Staphylococcal Superantigenic Toxins in Human Melanocytes.

Biomedicines 2022 Jun 14;10(6). Epub 2022 Jun 14.

Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

, a gram-positive bacterium, causes toxic shock through the production of superantigenic toxins (sAgs) known as Staphylococcal enterotoxins (SE), serotypes A-J (SEA, SEB, etc.), and toxic shock syndrome toxin-1 (TSST-1). The chronology of host transcriptomic events that characterizes the response to the pathogenesis of superantigenic toxicity remains uncertain. Read More

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Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection-Protocol Optimization and Pitfalls.

Antioxidants (Basel) 2022 Jun 16;11(6). Epub 2022 Jun 16.

Department of Cardiology 1-Molecular Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases. We established a protocol for high-performance liquid chromatography/electrochemical detection (HPLC/ECD)-based determination of BH4 in tissue samples. We first determined the optimal storage and work-up conditions for authentic BH4 and its oxidation product dihydrobiopterin (BH2) under various conditions (pH, temperature, presence of antioxidants, metal chelators, and storage time). Read More

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ARG1 as a promising biomarker for sepsis diagnosis and prognosis: evidence from WGCNA and PPI network.

Hereditas 2022 Jun 23;159(1):27. Epub 2022 Jun 23.

School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.

Background: Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated host response to infection. Sepsis remains a major global concern with high mortality and morbidity, while management of sepsis patients relies heavily on early recognition and rapid stratification. This study aims to identify the crucial genes and biomarkers for sepsis which could guide clinicians to make rapid diagnosis and prognostication. Read More

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Low-dose Lung Radiotherapy for COVID-19-related Pneumonia: Preliminary Results of the Italian Mono-institutional COLOR-19 Trial.

In Vivo 2022 Jul-Aug;36(4):1959-1965

Medical Physics Department, ASST Spedali Civili Hospital, Brescia, Italy.

Aim: To evaluate the feasibility and tolerability of low-dose radiotherapy (LDRT) delivered to both lungs in the treatment of SARS-CoV-2-immune-mediated pneumonia in the COLOR-19 study (NCT0437747).

Patients And Methods: From May 2020 to April 2021 at Brescia University Radiation Oncology Department, three patients with COVID-19-related pneumonia were treated with LDRT according to the COLOR-19 protocol. All patients were treated with a single fraction at the average prescription dose of 0. Read More

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Impact of revised EORTC/MSGERC 2020 criteria on diagnosis and prognosis of invasive pulmonary aspergillosis in patients with hematological malignancies undergoing bronchoscopy.

J Mycol Med 2022 Jun 15;32(4):101304. Epub 2022 Jun 15.

Uludağ University Faculty of Medicine, Department of Hematology, Bursa, Turkey.

Introduction: The first consensus definitions for invasive fungal diseases (IFD) were published in 2002. Advances in diagnostic tests and a clear need for improvement in certain areas led to a revision of these definitions in 2008. However, growing data on Aspergillus galactomannan (GM) thresholds and the introduction of new polymerase chain reaction-based diagnostic tests resulted in a further update by EORTC and Mycoses Study Group Education and Research Consortium (MSGERC) in 2020. Read More

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Comparison between hospital- and community-acquired septic shock in children: a single-center retrospective cohort study.

World J Pediatr 2022 Jun 23. Epub 2022 Jun 23.

Pediatric Intensive Care Unit, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, No. 56 Nan-Li-Shi Road, Beijing, 100045, China.

Background: We explored the differences in baseline characteristics, pathogens, complications, outcomes, and risk factors between children with hospital-acquired septic shock (HASS) and community-acquired septic shock (CASS) in the pediatric intensive care unit (PICU).

Methods: This retrospective study enrolled children with septic shock at the PICU of Beijing Children's Hospital from January 1, 2016, to December 31, 2019. The patients were followed up until 28 days after shock or death and were divided into the HASS and CASS group. Read More

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