40,251 results match your criteria Toxic Shock Syndrome


Next-generation sequencing diagnostics of bacteremia in pediatric sepsis.

Medicine (Baltimore) 2021 Jun;100(25):e26403

Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen.

Introduction: Sepsis and septic shock are the most severe forms of infection affecting predominantly elderly people, preterm and term neonates, and young infants. Even in high-income countries sepsis causes about 8% of admissions to pediatric intensive care units (PICUs). Early diagnosis, rapid anti-infective treatment, and prompt hemodynamic stabilization are crucial for patient survival. Read More

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Recurrent neonatal sepsis and progressive white matter injury in a premature newborn culture-positive for group B Streptococcus: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26387

Department of Pediatrics, Incheon Worker's Compensation Hospital, Incheon.

Rationale: Group B Streptococcus (GBS) remains a principal pathogen causing neonatal sepsis and meningitis, particularly in premature infants with relatively insufficient immunity. Recurrence may occur uncommonly, largely associated with subclinical mucosal persistence or repetitive exposure to exogenous sources. White matter injury (WMI) including cystic periventricular leukomalacia (PVL) has been associated with intrauterine infection/inflammation, and neonatal infection as a more significant predictor including postnatal sepsis and recurrent infection, even without microbial neuroinvasion. Read More

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A call for standardization: Practice patterns and management of critical illness-related corticosteroid insufficiency in surgical intensive care units.

Injury 2021 Jun 1. Epub 2021 Jun 1.

Baylor College of Medicine, Houston TX, 77030, USA. Electronic address:

Introduction: Critical illness-rlated corticosteroid insufficiency (CIRCI) is a known sequela of severe injury and illness, yet its diagnosis and management are challenging. We hypothesized that CIRCI has significant variability in its diagnosis and management within surgical intensive care units (SICUs). Our study aimed to assess the state of practice of CIRCI in the American College of Surgery Committee on Trauma (ACS COT) certified level 1 trauma centers. Read More

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Clinical features and development of Sepsis in Klebsiella pneumoniae infected liver abscess patients: a retrospective analysis of 135 cases.

BMC Infect Dis 2021 Jun 23;21(1):597. Epub 2021 Jun 23.

Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, No. 150, Ximen Road of Linhai, Taizhou, 317000, Zhejiang Province, China.

Background: Klebsiella pneumoniae is a primary pathogen of pyogenic liver abscess (PLA). However, little data are available on combination with sepsis. In this study, we aimed to evaluate the clinical characteristics and prognostic differences of PLA patients with sepsis. Read More

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Appropriateness of empirical antibiotic therapy and added value of adjunctive gentamicin in patients with septic shock: a prospective cohort study in the ICU.

Infect Dis (Lond) 2021 Jun 22:1-9. Epub 2021 Jun 22.

Department of Intensive Care Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

Objectives: To determine the appropriateness of empiric antibiotic therapy and the possible benefit of adding short-course gentamicin in septic shock patients with abdominal, urogenital, or an unknown focus. Secondary objectives were the effect of gentamicin addition on shock reversal and the incidence of a fungal infection.

Methods: Microbiological cultures, antibiotic treatment, and antibiotic resistance patterns of the cultured microorganisms were recorded during the first 5 days of admission. Read More

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Extracorporeal Membrane Oxygenation for Septic Shock in Children.

ASAIO J 2021 May 10. Epub 2021 May 10.

From the *ECMO Centre Karolinska, Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden †Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Extracorporeal membrane oxygenation (ECMO) is a rescue treatment used in children and adults with reversible cardiorespiratory failure. The role of ECMO is not fully established in pediatric sepsis. In this retrospective single-center study, we aimed to investigate risk factors and survival in pediatric septic shock supported with peripheral cannulation ECMO. Read More

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Septic Shock: A Race against Time.

Isr Med Assoc J 2021 Jun;23(6):390-392

Intensive Care Unit, Wolfson Medical Center, Holon, Israel.

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A bibliometric analysis of the application of procalcitonin in patients in the intensive care unit.

Ann Palliat Med 2021 Jun 21. Epub 2021 Jun 21.

Outpatient Health Examination Center, Shaanxi Provincial People's Hospital, Xi'an, China.

Background: Patients in the intensive care unit (ICU) often have serious infections, and anti-infection treatment is vital for these patients. Procalcitonin (PCT) is often used to identify bacterial infections and monitor the effectiveness of anti-infection treatments. This study aims to analyze the current research hotspots of the application of PCT in ICU patients, and to suggest future research directions. Read More

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[Utilization study in real clinical practice of ceftolozane/tazobactam vs aminoglycosides and/or colistin in the treatment of multirresistant or extremely resistant Pseudomonas aeruginosa].

Rev Esp Quimioter 2021 Jun 22. Epub 2021 Jun 22.

Andrea Pinilla Rello, Servicio de Farmacia Hospitalaria, Hospital Universitario Miguel Servet, Paseo Isabel la Católica 1-3, 50009, Zaragoza, Spain.

Objective: Comparative "real life" data on the effectiveness and safety of ceftolozane/tazobactam (C/T) versus other regimens (aminoglycosides/colistin/combination), in the treatment of multi-resistant (MDR) and extremely resistant (XDR) Pseudomonas aeruginosa (PA), are needed to establish positions.

Methods: Observational, retrospective study of patients with microbiological confirmation of MDR and XDR PA from July 2016 up to December 2018 in a tertiary hospital. Variables: age, sex, comorbidities, risk factors for multidrug resistance, variables related to infection, source of infection, microorganism and type of sample, antibiotic treatment, clinical cure, microbiological cure, recurrence, mortality on admission and 30 days post-discharge. Read More

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Can Omentin-1 Be a Prognostic Marker in Surgical Intensive Care Patients?

Turk J Med Sci 2021 Jun 22. Epub 2021 Jun 22.

Purpose: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. Read More

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The effect of perioperative hemadsorption in patients operated for acute infective endocarditis - A randomized, controlled study.

Artif Organs 2021 Jun 21. Epub 2021 Jun 21.

Department of Thoracic- and Cardiovascular Surgery, University Hospital, Georg-August-University, Robert Koch Strasse 40, 37075, Göttingen, Germany.

Objectives: Patients operated for infective endocarditis (IE) are at high risk of developing an excessive systemic hyper-inflammatory state, resulting in systemic inflammatory response syndrome (SIRS) and septic shock. Hemadsorption (HA) by cytokine adsorbers has been successfully applied to remove inflammatory mediators. This randomized controlled trial investigates the effect of perioperative HA therapy on inflammatory parameters and hemodynamic status in patients operated for IE. Read More

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[Erratum to: Mortality in sepsis and septic shock in Germany. Results of a systematic review and meta-analysis].

Anaesthesist 2021 Jun 21. Epub 2021 Jun 21.

Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie, Vivantes Klinikum Neukölln, Berlin, Deutschland.

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Acute triiodothyronine treatment and red blood cell sedimentation rate (ESR) in critically ill COVID-19 patients: A novel association?

Clin Hemorheol Microcirc 2021 Jun 11. Epub 2021 Jun 11.

Department of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Sepsis and septic shock result in impaired microcirculation and red blood cell rheology which lead to tissue hypoxia and multi-organ failure. Early administration of triiodothyronine prevents tissue hypoxia in experimental sepsis. In this context, a clinical trial was initiated to test the efficacy of acute triiodothyronine administration to combat tissue hypoxia in critically ill COVID19 patients. Read More

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Prediction of Impending Septic Shock in Children With Sepsis.

Crit Care Explor 2021 Jun 15;3(6):e0442. Epub 2021 Jun 15.

Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD.

Objectives: Sepsis and septic shock are leading causes of in-hospital mortality. Timely treatment is crucial in improving patient outcome, yet treatment delays remain common. Early prediction of those patients with sepsis who will progress to its most severe form, septic shock, can increase the actionable window for interventions. Read More

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Meningitis caused by in a locally advanced cervical cancer patient with pyometra: A case report.

Gynecol Oncol Rep 2021 Aug 29;37:100799. Epub 2021 May 29.

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Locally advanced cervical cancer occasionally induces pyometra, but there have been no reports of meningitis where pyometra is the cause of infection. Here, we report a case of meningitis related to pyometra during concurrent chemoradiotherapy (CCRT) in a cervical cancer patient. The patient, a 77-year-old woman, was diagnosed with Stage IIB (FIGO 2018) cervical adenocarcinoma, and CCRT was initiated. Read More

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Hypocoagulable Tendency on Thromboelastometry Associated With Severity and Anticoagulation Timing in Pediatric Septic Shock: A Prospective Observational Study.

Front Pediatr 2021 2;9:676565. Epub 2021 Jun 2.

University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.

To identify whether coagulation profiles using thromboelastometry are associated with outcomes in pediatric septic shock. The primary outcomes were the development of disseminated intravascular coagulation (DIC) and the severity of the pediatric intensive care unit (PICU) existing scoring systems, while the secondary outcome was hospital mortality. This study aimed to contribute to current findings of the limitations of conventional tests in determining the optimal timing of anticoagulation in sepsis. Read More

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Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis.

Cureus 2021 May 13;13(5):e15019. Epub 2021 May 13.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, USA.

Sepsis is a condition characterized by high morbidity and mortality which is commonly encountered in an emergency and critical care setting. Despite a substantial body of research, the ideal biomarker for the diagnosis and prognostic stratification of septic patients remains unknown. This review aimed to summarize the publications referring to the validity of the biomarker presepsin when used for the detection, monitoring and prognosis in patients suffering with sepsis. Read More

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Infections in the Paediatric Intensive Care Unit: Illustrated Cases.

Case Rep Pediatr 2021 4;2021:6661932. Epub 2021 Jun 4.

Paediatric Intensive Care Unit, Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong.

is known to be one of the most common gram-positive microorganisms and an important pathogen associated with sepsis and toxic shock. We present four anonymized consecutive cases in a paediatric intensive care unit (PICU) to illustrate the different clinical manifestations of staphylococcal infections, including local infection versus systemic infection, toxic shock versus septic shock, and osteomyelitis. Eczema, short gut syndrome, and scald injury may be associated. Read More

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in Peritoneal Dialysis-related Peritonitis Diagnosed by Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):245-248

Department of Internal Medicine; Department of Nephrology Service, University Hospital, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

Fungal peritonitis (FP) is a rare complication of peritoneal dialysis (PD). Candida tropicalis infections are rarely reported in literature. The authors present the first case of FP with peritoneal abscess due to C. Read More

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DISTINGUISHING SEPTIC SHOCK FROM NON-SEPTIC SHOCK IN POSTSURGICAL PATIENTS USING GENE EXPRESSION.

J Infect 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Faculty of Medicine, University of Valladolid. 7 Ramón y Cajal Ave, 47005 Valladolid, Spain.; BioCritic. Group for Biomedical Research in Critical Care Medicine. Valladolid, Spain.; Anesthesiology and Resuscitation Service, University Clinical Hospital of Valladolid. 3 Ramón y Cajal Ave, 47003 Valladolid, Spain.

Objectives: To obtain a gene expression signature to distinguish between septic shock and non-septic shock in postoperative patients, since patients with both conditions show similar signs and symptoms.

Methods: Differentially expressed genes were selected by microarray analysis in the discovery cohort. These genes were evaluated by quantitative real time polymerase chain reactions in the validation cohort to determine their reliability and predictive capacity by receiver operating characteristic curve analysis. Read More

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Coronavirus Disease 2019 and Antibiotic Stewardship-Antibiotic Usage in Adult Patients: Is It Necessary? When Should It be Concerned?

Balkan Med J 2021 May;38(3):150-155

Department of Infectious Diseases and Clinical Microbiology, Uludağ University School of Medicine, Bursa, Turkey.

Antibiotic consumption rates were quite high in number, although the bacterial coinfection rates were low in coronavirus disease 2019 pneumonia. Generally, empirical antibiotic treatment is not recommended for uncomplicated coronavirus disease 2019 mild to moderate pneumonia cases. On the other hand, antibiotic treatment and de-escalation are recommended for intubated intensive care unit patients or critical patients with sepsis, septic shock, or acute respiratory distress syndrome. Read More

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Application value of doppler ultrasound in renal hemodynamic monitoring in patients with septic shock.

Panminerva Med 2021 Jun 18. Epub 2021 Jun 18.

Department of General Practice, Huizhou Municipal Central Hospital, Huizhou, China.

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Anakinra treats fulminant myocarditis from septicaemia and haemophagocytic lymphohistiocytosis: a case report.

Eur Heart J Case Rep 2021 Jun 16;5(6):ytab201. Epub 2021 Jun 16.

Centre for Inherited Heart Muscle Conditions, Department of Cardiology, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK.

Background: Fulminant myocarditis is a life-threatening condition characterized by acute cardiac dysfunction requiring pharmacological or mechanical circulatory support. Haemophagocytic lymphohistiocytosis (HLH) is an uncommon state of immune dysregulation and overactivation. Inflammation mediated by interleukin-1 (IL-1) is thought to play a role in the pathogenesis of myocarditis and HLH, and there is some evidence that the IL-1 receptor antagonist Anakinra may play a role in treating both these conditions. Read More

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Coronary sinus endocarditis in a hemodialysis patient: A case report and review of literature.

World J Clin Cases 2021 Jun;9(17):4348-4356

Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Seoul 05278, South Korea.

Background: Infective endocarditis is more common in hemodialysis patients than in the general population and is sometimes difficult to diagnose. Isolated coronary sinus (CS) vegetation is extremely rare and has a good prognosis, but complicated CS vegetation may have a poorer clinical course. We report a case of CS vegetation accidentally found echocardiography in a hemodialysis patient with undifferentiated shock. Read More

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Toxic shock syndrome associated with menstrual cup use.

IDCases 2021 28;25:e01171. Epub 2021 May 28.

Director of Infectious Diseases Department, Jamaica Hospital Medical Center, Queens, NY, United States.

Staphylococcal toxic shock syndrome is a rare but life-threatening condition. It occurs when bacteria colonizing the vagina of a healthy woman, produce toxic shock syndrome toxin 1 activating the immune system and leading to multiorgan failure. Menstrual cups also known as vaginal cups are usually used as alternatives to other intravaginal products for menstrual blood collection. Read More

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The Efficacy and Safety of Esmolol for Septic Shock: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Front Pharmacol 2021 1;12:682232. Epub 2021 Jun 1.

Beijing Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China.

The meta-analysis aims to identify whether septic shock patients can benefit from esmolol. The relevant studies from MEDLINE, Cochrane Library, Embase were searched by two independent investigators using a variety of keywords. Stata software (version 12. Read More

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Safety and Efficacy of Replacing Vindesine with Vincristine in R-ACVBP Regimen for the Treatment of Large B Cell Lymphomas.

Clin Lymphoma Myeloma Leuk 2021 May 24. Epub 2021 May 24.

Hematology/Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Background: Intensified immunochemotherapy with rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (R-ACVBP) improves outcomes in younger adults with diffuse large B-cell lymphomas (DLBCL) compared with R-CHOP. Due to vindesine unavailability, we assessed the safety and efficacy of replacing vindesine with vincristine in a modified R-ACVBP protocol (mR-ACVBP).

Methods: This is a retrospective study including all consecutive adult patients with newly diagnosed DLBCL who received first-line mR-ACVBP. Read More

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Emphysematous pancreatitis: a rare entity with characteristic radiological findings.

Rev Esp Enferm Dig 2021 Jun 18. Epub 2021 Jun 18.

Aparato Digestivo, Hospital General Universitario de Ciudad Real, España.

Case Report: A 53-year-old male with a history of acute pancreatitis of biliary origin and subsequent laparoscopic cholecystectomy. Current hospitalization with a diagnosis of acute pancreatitis. Seventy-two hours after the onset of symptoms, he had fever, uncontrolled pain, and elevated inflammatory markers. Read More

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A rapid aptamer-based fluorescence assay for the detection of lipopolysaccharides using SYBR Green I.

Luminescence 2021 Jun 16. Epub 2021 Jun 16.

Department of Instrumentation and Applied Physics, Indian Institute of Science Bangalore.

Lipopolysaccharides (endotoxins), found on Gram-negative bacteria, can trigger a severe immune response in humans leading to septic shock and in extreme cases, even death. Hence, the detection and neutralization of lipopolysaccharides (LPS) is of utmost importance in the pharmaceutical and medical industries. The FDA recommended detection method for LPS, the Limulus amebocyte lysate (LAL) assay, is expensive, time consuming, complex, and is prone to interference from proteases. Read More

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Early Resuscitation in Paediatric Sepsis Using Inotropes - A Randomised Controlled Pilot Study in the Emergency Department (RESPOND ED): Study Protocol and Analysis Plan.

Front Pediatr 2021 31;9:663028. Epub 2021 May 31.

Child Health Research Centre, The University of Queensland, and Paediatric Intensive Care Unit, Queensland Children's Hospital, Brisbane, QLD, Australia.

Septic shock in children still carries substantial mortality and morbidity. While resuscitation with 40-60 mL/kg intravenous fluid boluses remains a cornerstone of initial resuscitation, an increasing body of evidence indicates potential for harm related to high volume fluid administration. We hypothesize that a protocol on early use of inotropes in children with septic shock is feasible and will lead to less fluid bolus use compared to standard fluid resuscitation. Read More

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