POSTOPERATIVE SERUM LEVELS OF ENDOCAN ARE ASSOCIATED WITH THE DURATION OF NOREPINEPHRINE SUPPORT AFTER CORONARY ARTERY BYPASS SURGERY.
- Adrien Bouglé,
- Pierre-Antoine Allain,
- Séverine Favard,
- Nora Ait Hamou,
- Aude Carillion,
- Pascal Leprince,
- Benjamin Granger,
- Julien Amour
Anaesth Crit Care Pain Med 2018 Feb 21. Epub 2018 Feb 21.
Sorbonne Universités, UPMC Univ Paris 06, Department of Anaesthesiology and Critical Care Medicine, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR INSERM 1166, IHU ICAN, Hôpital Pitié-Salpêtrière, Paris, France.
Background: Cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response and an endothelial dysfunction, whose qualitative assessment appears to be a major issue. Endocan (ESM-1, endothelial cell specific molecule - 1) is a protein preferentially expressed by the endothelium and previously associated with prognosis of septic shock or acute respiratory distress syndrome. In this pilot study, we investigated the kinetic of Endocan in planned coronary artery bypass grafting (CABG) surgery with CPB. Read More