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    Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock.
    Crit Care Med 2017 Apr 25. Epub 2017 Apr 25.
    1INSERM, UMRS 1138, Team 1, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France. 2Intensive Care Unit, Raymond Poincaré Hospital, Assistance Publique Hôpitaux de Paris (APHP), Garches, France. 3Intensive Care Unit, René Dubos Hospital, Pontoise, France. 4INSERM, UMRS 1173, Team 2, Versailles-Saint-Quentin-en-Yvelines University, Versailles, France. 5Assistance Publique Hôpitaux de Paris (APHP), Paris, France. 6Department of Physiology, Universidad de La Laguna, Santa Cruz de Tenerife, Spain. 7INSERM, Clinical Investigation Centre 1433, Vandoeuvre-lès-Nancy, France.
    Objectives: Vascular mineralocorticoid receptors play a role in vascular tone and blood pressure regulation, might participate in the pathophysiology of circulatory failure during sepsis, and represent a potential therapeutic target in this disease. We aimed to study the effects of mineralocorticoids and the involvement of vascular mineralocorticoid receptors in murine endotoxic and human septic shock.

    Design: Experimental study. Read More

    Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis.
    Crit Care Med 2017 Apr 25. Epub 2017 Apr 25.
    1Department of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. 2Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
    Objective: Several studies have reported a survival benefit for polymyxin B hemoperfusion treatment in patients with severe sepsis and septic shock. However, recently, a propensity-matched analysis and a randomized controlled trial reported no survival benefit for polymyxin B hemoperfusion treatment. We performed an up-to-date meta-analysis to determine the effect of polymyxin B hemoperfusion treatment on mortality in patients with severe sepsis and septic shock. Read More

    Acute bag-valve breathing maneuvers plus manual chest compression is safe during stable septic shock: a randomized clinical trial.
    Rev Bras Ter Intensiva 2017 Jan-Mar;29(1):14-22
    Unidade de Terapia Intensiva, Hospital das Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
    Objective:: To evaluate the effects of bag-valve breathing maneuvers combined with standard manual chest compression techniques on safety, hemodynamics and oxygenation in stable septic shock patients.

    Design:: A parallel, assessor-blinded, randomized trial of two groups. A computer-generated list of random numbers was prepared by an independent researcher to allocate treatments. Read More

    [Leading causes of death during the induction therapy in pediatric patients with acute lymphoblastic leukemia].
    Rev Med Inst Mex Seguro Soc 2017 May-Jun;55(3):286-291
    Servicio de Hematología Pediátrica, Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Background: Leukemias are the leading cause of childhood cancer. In most developed countries 1-2% of patients die during remission induction; however, in developing countries, this figure is higher and the causes of death apparently vary among the populations studied. The aim was to determine the cause of death during remission induction in pediatric patients with acute lymphoblastic leukemia (ALL) in the hospital "Dr. Read More

    Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis.
    Front Cell Infect Microbiol 2017 7;7:116. Epub 2017 Apr 7.
    Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São PauloSão Paulo, Brazil.
    Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma gondii were more susceptible to sepsis induced by cecal ligation and puncture (CLP). Read More

    Importance of Pharmacy Involvement in the Treatment of Sepsis.
    Hosp Pharm 2017 Mar;52(3):191-197
    Purpose: A review of the impact of pharmacists on appropriate medication selection, timing of administration, and as members of a multidisciplinary sepsis response team. Summary: Early goal-directed therapy (EGDT), currently recommended by the 2013 Surviving Sepsis Campaign guidelines for the management of patients with sepsis, includes the administration of appropriate antibiotics in patients with septic shock within the first hour. Multidisciplinary teams containing pharmacists have been shown to decrease time to antibiotic delivery, time to antibiotic administration, and patient mortality. Read More

    Compliance with Updated Sepsis Bundles to Meet New Sepsis Core Measure in a Tertiary Care Hospital.
    Hosp Pharm 2017 Mar;52(3):177-186
    Background: The updated Surviving Sepsis Campaign care bundles are associated with improved outcomes in patients with sepsis, yet adherence to the bundles remains inconsistent. The Centers for Medicare & Medicaid Services has adopted similar care bundles as a core measure that went into effect with October 1, 2015 discharges. Objective: The aim of this study was to assess bundle compliance, length of stay (LOS), and in-hospital mortality before and after introduction of the new sepsis core measure. Read More

    Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia.
    Sci Rep 2017 Apr 24;7(1):1083. Epub 2017 Apr 24.
    Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
    We aimed to determine the clinical and microbiological characteristics of Candida bloodstream infections in children and the impact of therapeutic strategies on outcomes. All pediatric patients with candidemia from a medical center in Taiwan over a 13-year period (2003-2015) were included and a total of 262 patients with 319 episodes of candidemia were analyzed. Overall susceptibility to fluconazole was 86. Read More

    Management and outcomes of severe dengue patients presenting with sepsis in a tropical country.
    PLoS One 2017 24;12(4):e0176233. Epub 2017 Apr 24.
    Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
    Background: Dengue is a common cause of infection in adults in tropical countries. Sepsis is a syndrome of systemic manifestations induced by infection of any organisms; including bacterial, fungal and viral agents. Here, we investigated the diagnosis, management and outcomes of dengue patients presenting with sepsis in a prospective study of community-acquired sepsis in Thailand. Read More

    Does bowel preparation for inflammatory bowel disease surgery matter?
    Colorectal Dis 2017 Apr 24. Epub 2017 Apr 24.
    Department of Surgery, Division of General Surgery, Icahn School of Medicine at Mount Sinai.
    Aim: The purpose of this study is to determine if bowel preparation influences outcomes in inflammatory bowel disease patients undergoing surgery.

    Methods: The American College Surgeons National Surgical Quality Improvement Program, Procedure Targeted Colectomy databases from 2012-2014 were analyzed. Inflammatory bowel disease patients undergoing colorectal resection with or without bowel preparation were included in the study. Read More

    Bacteraemia due to AmpC β-lactamase-producing Escherichia coli in hospitalized cancer patients: risk factors, antibiotic therapy, and outcomes.
    Diagn Microbiol Infect Dis 2017 Apr 12. Epub 2017 Apr 12.
    Department of Medical Biochemistry & Cell Biology, School of Medicine, Nankai University, 94 Weijin Road, Nankai District, Tianjin, 300071, PR China. Electronic address:
    AmpC β-lactamase-producing Escherichia coli (AmpC-EC) is one of the main antimicrobial resistant pathogens in patients with cancer. A cohort study was performed to evaluate the risk factors, antibiotic therapy, and outcomes of AmpC-EC bacteraemia in hospitalized cancer patients from September 2012 through December 2015. Two hundred forty-eight cases of E. Read More

    Distinguishing septic from normal donors by detection of sPLA2-IIA from human plasma using a microsieve-based immunoassay.
    J Immunol Methods 2017 Apr 19. Epub 2017 Apr 19.
    Medical Cell BioPhysics Group, MIRA Institute, University of Twente, Hallenweg 23, 7522 NH Enschede, The Netherlands.
    Bloodstream infections that progress to septic shock are responsible for hundreds of thousands of deaths each year, and are associated with significant healthcare costs. Recent studies have shown that a member of the secreted phospholipase protein family, termed sPLA2-IIA, may play a role during the innate immune response to bacterial infections, and is elevated in the plasma of septic patients. In this report, the feasibility of a simple microsieve-based sPLA2-IIA detection immunoassay was explored. Read More

    In-hospital mortality in cirrhotic patients at a tertiary care center.
    Rev Gastroenterol Mex 2017 Apr 19. Epub 2017 Apr 19.
    Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia.
    Introduction: Cirrhosis of the liver is known for its high risk of mortality associated with episodes of acute decompensation. There is an even greater risk in patients that present with acute-on-chronic liver failure. The identification of patients at higher risk for adverse outcomes can aid in making the clinical decisions that will improve the prognosis for these patients. Read More

    Epigallocatechin gallate protects BEAS-2B cells from lipopolysaccharide-induced apoptosis through upregulation of gastrin-releasing peptide.
    Mol Cell Biochem 2017 Apr 21. Epub 2017 Apr 21.
    Department of Biochemistry, Karnatak University, Dharwad, India.
    Gastrin-releasing peptide (GRP) plays a major role in the development and maintenance of lung epithelial cells by promoting cell division, whereas its suppression causes growth arrest and apoptosis. The present study shows that human bronchial epithelial BEAS-2B cells challenged with lipopolysaccharide (LPS), an endotoxin from gram-negative bacteria, downregulated GRP expression and induced apoptosis via upregulation of p53 and active caspase-3, signifying the importance of GRP in lung epithelial cell survival. However, in the presence of epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, BEAS-2B cells resisted LPS-induced apoptosis and restored the expression of GRP and its downstream effectors such as epidermal growth factor receptor and NF-κB, as analysed by immunoblotting and qPCR. Read More

    Risk score for cardiac surgery in active left-sided infective endocarditis.
    Heart 2017 Apr 21. Epub 2017 Apr 21.
    Department of Cardiology, Instituto de Ciencias del Corazón (ICICOR), CIBERCV, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
    Objective: To develop and validate a calculator to predict the risk of in-hospital mortality in patients with active infective endocarditis (IE) undergoing cardiac surgery.

    Methods: Thousand two hundred and ninety-nine consecutive patients with IE were prospectively recruited (1996-2014) and retrospectively analysed. Left-sided patients who underwent cardiac surgery (n=671) form our study population and were randomised into development (n=424) and validation (n=247) samples. Read More

    Multilateral Functional Alterations of Human Neutrophils in Sepsis: From the Point of Diagnosis to the Seventh Day.
    Shock 2017 Apr 20. Epub 2017 Apr 20.
    *Department of Acute Critical Care and Disaster Medicine, Graduate School of Tokyo Medical and Dental University, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan †Department of Pediatrics and Developmental Biology, Graduate School of Tokyo Medical and Dental University, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
    Neutrophil functional changes caused by sepsis itself and their time-course variation have not been fully elucidated because previous studies targeted patients who had received therapeutic interventions. We explored the multilateral functions of circulating neutrophils in patients with severe sepsis or septic shock who had not yet undergone interventions, and followed their changes. Patients were treated based on the Surviving Sepsis Campaign Guidelines 2012. Read More

    Common Carotid Artery Sonography Versus Transthoracic Echocardiography for Cardiac Output Measurements in Intensive Care Unit Patients.
    J Ultrasound Med 2017 Apr 21. Epub 2017 Apr 21.
    Department of Critical Care Medicine, Central South University, Changsha, China.
    Objectives: This study was designed to test the effectiveness of common carotid artery sonography in comparison with transthoracic echocardiography (TTE) for cardiac output measurements to provide an easier alternative for cardiac output monitoring in the intensive care unit.

    Methods: This study included 148 patients who had common carotid artery Doppler examinations and TTE performed within 8 hours of each other, and the cardiac output measurement results were compared with each other.

    Results: The mean age of the participants ± SD was 56. Read More

    Diagnosis, treatment and prognosis of small bowel volvulus in adults: A monocentric summary of a rare small intestinal obstruction.
    PLoS One 2017 20;12(4):e0175866. Epub 2017 Apr 20.
    Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China.
    Objectives: Small bowel volvulus is a rare disease, which is also challenging to diagnose. The aims of this study were to characterize the clinical and radiological features associated with small bowel volvulus and treatment and to identify risk factors for associated small bowel necrosis.

    Methods: Patients with small bowel volvulus who underwent operations from January 2001 to December 2015 at the First Affiliated Hospital of China Medical University (Shenyang, China) were reviewed. Read More

    Physician Variation in Time to Antimicrobial Treatment for Septic Patients Presenting to the Emergency Department.
    Crit Care Med 2017 Apr 6. Epub 2017 Apr 6.
    1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Intermountain Medical Center, Salt Lake City, UT.2Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT.3Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA.4Department of Medicine, University of Washington School of Medicine, Seattle, WA.
    Objectives: Delayed initiation of appropriate antimicrobials is linked to higher sepsis mortality. We investigated interphysician variation in septic patients' door-to-antimicrobial time.

    Design: Retrospective cohort study. Read More

    A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report.
    Paediatr Int Child Health 2017 Apr 20:1-4. Epub 2017 Apr 20.
    b Department of Pediatrics , Ghent University Hospital , Ghent , Belgium.
    A 2-year-old boy presented with severe hypotension and acute kidney injury after a prodrome of non-bloody diarrhoea and fever in the preceding 3 days. He had a mild Ebstein cardiac anomaly but otherwise a normal past history and growth. On examination, he looked ill, his temperature was 37. Read More

    Persistence of Virologic Response after Liver Transplant in Hepatitis C Patients Treated with Ledipasvir / Sofosbuvir Plus Ribavirin Pretransplant.
    Ann Hepatol 2017 May - Jun;16(3):375-381
    Department for Gastroenterology and Hepatology, University Hospital Zurich, Switzerland.
    Introduction: Recurrence of HCV infection in patients with chronic hepatitis C virus (HCV) at the time of liver transplantation is nearly universal and reduces the likelihood of graft and patient survival.

    Materials And Methods: We evaluated outcomes of 17 patients (16 with HCV genotype 1 and 1 with genotype 4) who received up to 12 or 24 weeks of ledipasvir/sofosbuvir plus ribavirin prior to or up to the time of liver transplant in the SOLAR-1 and SOLAR-2 trials. In all patients, HCV RNA was < 15 IU/mL prior to transplant. Read More

    A small 'lick' will sink a great ship: fulminant septicaemia after dog saliva wound treatment in an asplenic patient.
    Int Wound J 2017 Apr 19. Epub 2017 Apr 19.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, Innsbruck, Austria.
    Capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. An infection can cause severe sepsis with acral necrosis and is potentially fatal. Here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. Read More

    Outcome of patients with septic shock and high-dose vasopressor therapy.
    Ann Intensive Care 2017 Dec 20;7(1):43. Epub 2017 Apr 20.
    Service de Réanimation Médicale Brabois, Pôle Cardiovasculaire et Réanimation Médicale, Hôpital Brabois, CHU Nancy, 54511, Vandoeuvre les Nancy, France.
    Background: Despite the dissemination of international guidelines, mortality from septic shock remains high. Norepinephrine is recommended as first-line vasopressor therapy with a target mean arterial pressure of 65 mmHg. High-dose vasopressor (HDV) may also be required. Read More

    Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis.
    Inflamm Res 2017 Apr 19. Epub 2017 Apr 19.
    Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research Perth, Royal Perth Hospital, GPO Box X2213, Perth, WA 6001, Australia.
    Objective And Design: Resistin and neutrophil gelatinase-associated lipocalin (NGAL) are upregulated in circulating leucocytes in sepsis, but the significance of this is uncertain. We evaluated associations between Resistin and NGAL with endothelial cell activation and clinical outcomes in a prospective observational study in the Emergency Department (ED).

    Methods: Serum levels of Resistin, NGAL, inflammatory cytokines (IL-6, IL-10) and soluble endothelial adhesion molecules (VCAM-1, ICAM-1) were measured at defined time points up to 24 h. Read More

    Gastrointestinal Mucormycosis of the Jejunum in an Immunocompetent Patient: A Case Report.
    Medicine (Baltimore) 2017 Apr;96(16):e6360
    aDepartment of Surgery bDepartment of General Surgery cDepartment of Intensive Care Unit, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Rationale: Gastrointestinal Mucormycosis (GIM) is a kind of opportunistic fungal infection with poor prognosis. It usually occurs in patients with immune deficiency. We reported a case of immunocompetent male patient. Read More

    Population-Based Epidemiology of Sepsis in a Subdistrict of Beijing.
    Crit Care Med 2017 Apr 18. Epub 2017 Apr 18.
    1Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China. 2Department of Critical Care Medicine, China Rehabilitation Research Center, Beijing, China. 3Department of General Internal Medicine, Fuxing Hospital, Capital Medical University, Beijing, China. 4Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing, China. 5Department of Critical Care Medicine, Peking University People's Hospital, Beijing, China. 6Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Objective: Information about the epidemiology of sepsis in community residents in China remains scarce and incomplete. The purpose of this study was to describe the occurrence rate and outcome of sepsis in Yuetan Subdistrict of Beijing and to estimate the occurrence rate of sepsis in China.

    Design: Retrospective cohort study. Read More

    [Metabolism of high density lipoprotein and the research progress of its effects on sepsis].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Apr;29(4):377-380
    Department of Anesthesiology, the Affiliated Pulmonary Hospital of Tongji University, Shanghai 200433, China. Corresponding author: Lyu Xin, Email:
    Objective: Sepsis is a high-risk factor for the death of critical patients. High density lipoprotein (HDL) are the major protective serum proteins, and the serum levels of HDL are closely related to the severity of sepsis. The anti-inflammatory and anti-oxidation properties of HDL, may be able to play an important role in the innate immune response. Read More

    [Clinical value of serum endocan and procalcitonin in early diagnosis and prognosis evaluation of sepsis].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Apr;29(4):321-326
    Department of Geriatric, Shijiazhuang Chinese Medicine Hospital, Shijiazhuang 050051, Hebei, China (Zhao R); Department of Emergency, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, China (Dong SM). Corresponding author: Dong Shimin, Email:
    Objective: To investigate the clinical value of serum endocan and procalcitonin (PCT) in early diagnosis and prognosis evaluation of sepsis.

    Methods: The patients with systemic inflammatory response syndrome (SIRS, n = 26) and sepsis (n = 78) admitted to intensive care unit (ICU) of the Third Hospital of Hebei Medical University from December 2014 to December 2016 were enrolled. According to the severity of disease, the sepsis patients were divided into general sepsis group (n = 20), severe sepsis group (n = 24), and septic shock group (n = 34). Read More

    Sepsis and Septic Shock: Current Treatment Strategies and New Approaches.
    Eurasian J Med 2017 Feb;49(1):53-58
    Department of Pharmacology, Atatürk University School of Medicine, Erzurum, Turkey.
    Sepsis is a complex condition characterized by the simultaneous activation of inflammation and coagulation in response to microbial insult. These events manifest as systemic inflammatory response syndrome or sepsis symptoms through the release of proinflammatory cytokines, procoagulants, and adhesion molecules from immune cells and/or damaged endothelium. Today, sepsis is a severe multisystem disease with difficult treatments for its manifestations and high mortality rates. Read More

    [Extracorporeal membrane oxygenation in critically ill neonates and children].
    Arch Pediatr 2017 Apr 14. Epub 2017 Apr 14.
    Service de réanimation néonatale et pédiatrique, CHU d'Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Unité Inserm U1141, hôpital Robert-Debré, 75019 Paris, France.
    Extracorporeal membrane oxygenation is used as a last resort during neonatal and pediatric resuscitation in case of refractory circulatory or respiratory failure under maximum conventional therapies. Different types of ECMO can be used depending on the initial failure. The main indications for ECMO are refractory respiratory failure (acute respiratory distress syndrome, status asthmaticus, severe pneumonia, meconium aspiration syndrome, pulmonary hypertension) and refractory circulatory failure (cardiogenic shock, septic shock, refractory cardiac arrest). Read More

    MR-Proadm Elevation Upon ICU Admission Predicts the Outcome of Septic Patients and is Correlated with Upcoming Fluid Overload.
    Shock 2017 Apr 14. Epub 2017 Apr 14.
    *Service de Réanimation Médicale, Hôpital Bocage Central, C.H.U. DIJON, 14 rue Gaffarel, B.P. 77908-21079 DIJON CEDEX, France †UMR 1231, INSERM, « Lipness » Team, University of Burgundy, 7 Bd Jeanne d'Arc, 21000 DIJON, France ‡ThermoFisher Scientific, Neuendorfstr. 25 16761 HENNIGSDORF, Germany.
    Background: Among septic patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance. We evaluated the prognostic value of Procalcitonin (PCT), mid regional-proadrenomedullin (MR-proADM), copeptine and CT-proendothelin 1 (CT-ProET 1) concentrations.

    Methods: This was a prospective cohort study, which included 173 septic patient admitted to one ICU. Read More

    Severe Sepsis and Septic Shock Cases Meeting Guidelines Among Patients in a University Hospital Setting.
    J La State Med Soc 2017 Mar-Apr;169(2):57. Epub 2017 Apr 15.
    Department of Internal Medicine, University Hospital and Clinics, LSU Health, Lafayette.
    Background: A diagnosis of severe sepsis or septic shock has been shown to significantly increase mortality rate independent of other factors. Research has revealed all cause hospital case fatality rates have declined yet the percentage of severe sepsis cases continues to increase and age-adjusted mortality rates from severe sepsis and septic shock has significantly increased during the same time period. Patients with severe sepsis demonstrate ongoing mortality rate increases for up to 2 years following hospitalization when compared to aged matched controls of nonseptic patients. Read More

    Prognosis of patients with Acinetobacter baumannii infection in the intensive care unit: A retrospective analysis.
    Exp Ther Med 2017 Apr 21;13(4):1630-1633. Epub 2017 Feb 21.
    Department of Critical Care Medicine, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, P.R. China.
    The present retrospective study aimed to investigate the prognostic factors for critically ill patients with an Acinetobacter baumannii (A. baumannii) infection. A total of 37 patients from the intensive care unit (ICU) were enrolled in the study. Read More

    Inhalative and intravenous stimulation of soluble guanylate cyclase reduces pulmonary vascular resistance and increases cardiac output in experimental septic shock.
    Exp Ther Med 2017 Apr 21;13(4):1369-1375. Epub 2017 Feb 21.
    Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.
    The effects of inhaled and intravenous application of a guanylate cyclase stimulator (BAY 41-8543) on pulmonary vascular resistance (PVR) and cardiac output (CO) were investigated in an experimental model of septic shock. Following induction of septic shock, anaesthetized pigs (n=31) were randomly place into two groups receiving different interventions. Animals in the first group received intravenous BAY 41-8543 (0. Read More

    Impact of duration of hypotension prior to norepinephrine initiation in medical intensive care unit patients with septic shock: A prospective observational study.
    J Crit Care 2017 Apr 9;40:178-183. Epub 2017 Apr 9.
    Department of Medicine, Division of Pulmonary & Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
    Purpose: To determine the impact of duration of hypotension prior to norepinephrine initiation on outcomes in MICU patients with septic shock. We hypothesized increased duration of hypotension prior to norepinephrine initiation would be associated with an increased risk for ICU mortality.

    Materials And Methods: We conducted a prospective-observational study in the MICU of a single-center tertiary academic medical center. Read More

    Circulating biologically active adrenomedullin (bio-ADM) predicts hemodynamic support requirement and mortality during sepsis.
    Chest 2017 Apr 11. Epub 2017 Apr 11.
    Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. Electronic address:
    Background: The biological role of adrenomedullin, a hormone involved in hemodynamic homeostasis, is controversial in sepsis, since administration of either the peptide or an antibody against it may be beneficial.

    Methods: Plasma bio-ADM was assessed on days 1, 2 and 7 after randomization of 956 patients with sepsis or septic shock to albumin or crystalloids for fluid resuscitation in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial. We tested the association of bio-ADM and its time-dependent variation with fluid therapy, vasopressor administration, organ failures and mortality. Read More

    Sepsis-3 on the Block: What Does It Mean for Preclinical Sepsis Modeling?
    Shock 2017 May;47(5):658-660
    *Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria †The William Harvey Research Institute, Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, UK ‡Boston University School of Medicine, Boston, Massachusetts.
    To effectively improve outcomes of septic patients, we first need to elucidate the multifaceted pathogenesis of sepsis syndromes and related inflammatory conditions. In fulfillment of such needs, in February 2016, new definitions for sepsis and septic shock were published under the acronym Sepsis-3. Although aimed at the clinical area, Sepsis-3 will have an inevitable influence upon the field of translational research as well. Read More

    Volatile Sedation in Reversible Cerebral Vasoconstriction Syndrome: A Case Report.
    A A Case Rep 2017 Apr 13. Epub 2017 Apr 13.
    From the *Department of Anesthesiology and Critical Care, University of Freiburg Medical Center, Freiburg, Germany; and †Department of Neuroradiology, University of Freiburg Medical Center, Freiburg, Germany.
    Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by reversible multifocal narrowing of cerebral arteries heralded by sudden (thunderclap) headaches with or without neurological deficits, resolving within 3 months. It often occurs in the peripartum period. To date, the ideal treatment remains unclear. Read More

    Procalcitonin levels in sepsis and its association with clinical outcome in southern India.
    Trop Doct 2017 Jan 1:49475517702314. Epub 2017 Jan 1.
    2 Associate Professor, Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
    Procalcitonin has been found to be a good marker for the diagnosis of sepsis. However, data on procalcitonin levels to predict the clinical outcome in patients with sepsis are limited. The aim of our study was to estimate serum procalcitonin levels in patients with sepsis and to identify its relationship with the clinical outcome. Read More

    Hospital Dissemination of tst-1-Positive Clonal Complex 5 (CC5) Methicillin-Resistant Staphylococcus aureus.
    Front Cell Infect Microbiol 2017 31;7:101. Epub 2017 Mar 31.
    Clinical Laboratory, The Second Affiliated Hospital of Soochow UniversitySuzhou, China.
    Methicillin-resistant Staphylococcus aureus (MRSA), is one of the most prevalent clinical pathogens isolated from hospital settings, and has increasingly identified in community settings. In China, the SCCmecIII-ST239 strains are disseminated in different geographic regions, accounting for >75% of all MRSA isolates in some national studies. Here we characterized 150 non-duplicate MRSA isolates collected from February 2012 to May 2013 in a tertiary hospital in Suzhou, Eastern China, to explore the molecular epidemiology. Read More

    Nephrologists Hate the Dialysis Catheters: A Systemic Review of Dialysis Catheter Associated Infective Endocarditis.
    Case Rep Nephrol 2017 20;2017:9460671. Epub 2017 Mar 20.
    Department of Infectious Diseases, Maimonides Medical Center, Brooklyn, NY, USA.
    A 53-year-old Egyptian female with end stage renal disease, one month after start of hemodialysis via an internal jugular catheter, presented with fever and shortness of breath. She developed desquamating vesiculobullous lesions, widespread on her body. She was in profound septic shock and broad spectrum antibiotics were started with appropriate fluid replenishment. Read More

    Impact of Delayed Admission to the Intensive Care Unit from the Emergency Department upon Sepsis Outcomes and Sepsis Protocol Compliance.
    Crit Care Res Pract 2017 12;2017:9616545. Epub 2017 Mar 12.
    Department of Pulmonary and Critical Care, St. Elizabeth's Medical Center, Tufts University, Boston, MA, USA.
    Rationale. The impact of emergency department length of stay (EDLOS) upon sepsis outcomes needs clarification. We sought to better understand the relationship between EDLOS and both outcomes and protocol compliance in sepsis. Read More

    Pharmacokinetics of linezolid during continuous hemodiafiltration: A case report.
    J Infect Chemother 2017 Apr 10. Epub 2017 Apr 10.
    Department of Pharmacy, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu City, Oita 874-0011, Japan.
    The pharmacokinetics of linezolid clearance (CLLZD) during continuous hemodiafiltration (CHDF) has not been comprehensively analyzed. Here, we examined CLLZD by CHDF in a patient with septic shock and disseminated intravascular coagulation due to methicillin-resistant Staphylococcus aureus. The extraction ratio of LZD by CHDF was 22. Read More

    Clinical variables associated with poor outcome from sepsis-associated acute kidney injury and the relationship with timing of initiation of renal replacement therapy.
    J Crit Care 2017 Mar 30;40:154-160. Epub 2017 Mar 30.
    The Center for Critical Care Nephrology, CRISMA, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Purpose: Identify clinical variables associated with mortality in patients with sepsis-associated acute kidney injury (SA-AKI) receiving continuous renal replacement therapy (CRRT) and examine timing of initiation of CRRT in reference to those variables identified.

    Methods: Retrospective study conducted at two tertiary care hospitals including 939 septic shock patients with SA-AKI who received CRRT in the intensive care unit (ICU). Cox regression models were used to identify variables associated with 90-day mortality. Read More

    A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.
    Pediatr Crit Care Med 2017 Apr 12. Epub 2017 Apr 12.
    1Research Institute, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. 2Department of Pediatrics, Faculty of Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada. 3Department of Economics, Faculty of Public Affairs, Carleton University, Ottawa, ON, Canada. 4Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH. 5Department of Epidemiology, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, ON, Canada. 6Clinical Epidemiology Program, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, ON, Canada. 7Division of Critical Care, Department of Medicine, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Ottawa, ON, Canada. 8Section of Critical Care Medicine, Department of Pediatrics, Alberta Children's Hospital, Calgary, AB, Canada. 9Department of Pediatrics, CHU Sainte-Justine Hospital, Montreal, QC, Canada. 10Department of Pediatrics, Faculty of Medicine, British Columbia Women's and Children's Hospital, The University of British Columbia, Vancouver, BC, Canada. 11Department of Pediatrics, Faculty of Medicine, Montreal Children's Hospital, McGill University, Montreal, QC, Canada. 12Department of Critical Care Medicine, IWK Health Centre, Halifax, NS, Canada. 13Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
    Objective: To determine the feasibility of conducting a randomized controlled trial of corticosteroids in pediatric septic shock.

    Design: Randomized, double-blind, placebo controlled trial.

    Setting: Seven tertiary level PICUs in Canada. Read More

    Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis.
    Intensive Care Med Exp 2017 Dec 12;5(1):21. Epub 2017 Apr 12.
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: Recognition of cardiomyopathy in sepsis can be challenging due to the limitations of conventional measures such as ejection fraction (EF) and fractional shortening (FS) in the context of variable preload and afterload conditions. This study correlates myocardial function using strain echocardiography (SE) with cardiomyocyte oxidative stress in a murine model of sepsis.

    Methods: C57BL/6J mice were randomized into control (n = 10), sham (n = 25), and a cecal ligation and puncture (CLP) (n = 33) model of sepsis. Read More

    Infusion-Compatible Antibiotic Formulations for Rapid Administration to Improve Outcomes in Cancer Outpatients With Severe Sepsis and Septic Shock: The Sepsis STAT Pack.
    J Natl Compr Canc Netw 2017 Apr;15(4):457-464
    From Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington; Seattle Cancer Care Alliance; Department of Epidemiology, School of Public Health, University of Washington; School of Medicine, University of Washington; School of Pharmacy, University of Washington; Division of Hematology, Department of Medicine, University of Washington; and Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    Background: Patients with cancer are at high risk for severe sepsis and septic shock (SS/SSh), and a delay in receiving effective antibiotics is strongly associated with mortality. Delays are due to logistics of clinic flow and drug delivery. In an era of increasing antimicrobial resistance, combination therapy may be superior to monotherapy for patients with SS/SSh. Read More

    Nab-paclitaxel versus solvent-based paclitaxel in patients with previously treated advanced gastric cancer (ABSOLUTE): an open-label, randomised, non-inferiority, phase 3 trial.
    Lancet Gastroenterol Hepatol 2017 Apr 19;2(4):277-287. Epub 2017 Jan 19.
    Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.
    Background: Weekly administration of solvent-based paclitaxel is one of the standard second-line chemotherapy regimens for advanced gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) was developed to improve the solubility of paclitaxel and does not need premedication to avoid infusion-related reactions associated with solvent-based paclitaxel. Additionally, higher doses of nab-paclitaxel can be administered over a shorter infusion time and at higher drug concentrations compared with solvent-based paclitaxel. Read More

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