Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity.
- Callum Chalmers,
- Adrina Hema J Khemlani,
- Chae Ryeong Sohn,
- Jacelyn Mei San Loh,
- Catherine Jia-Yun Tsai,
- Thomas Proft
J Microbiol Immunol Infect 2017 Nov 13. Epub 2017 Nov 13.
Department of Molecular Medicine & Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address:
Background: Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil extracellular traps. SpnA consists of a C-terminal endo/exonuclease domain and a N-terminal domain of unknown function. Read More