1,815 results match your criteria Toxic Neuropathy


BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes.

Sci Rep 2020 May 29;10(1):8755. Epub 2020 May 29.

Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, Antwerp, Belgium.

Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, dilated cardiomyopathy or Charcot-Marie-Tooth type 2 neuropathy. Yet, it is unclear whether distinct molecular mechanisms underlie the variable clinical spectrum of the rare patients carrying these three heterozygous Pro209 mutations in BAG3. Here, we studied all three variants and compared them to the BAG3_Glu455Lys mutant, which causes dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1038/s41598-020-65664-zDOI Listing

FOLFIRINOX for the Treatment of Advanced Gastroesophageal Cancers: A Phase 2 Nonrandomized Clinical Trial.

JAMA Oncol 2020 May 29. Epub 2020 May 29.

Sylvester Comprehensive Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida.

Importance: Standard first-line regimens for patients with metastatic gastroesophageal adenocarcinomas have an approximate 40% objective response rate (ORR). The combination of leucovorin, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) has been efficacious as first-line therapy for other gastrointestinal cancers, such as pancreatic and colon cancers.

Objective: To evaluate the clinical activity and safety of FOLFIRINOX as first-line treatment for patients with advanced gastroesophageal adenocarcinoma. Read More

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http://dx.doi.org/10.1001/jamaoncol.2020.2020DOI Listing

Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy.

Cells 2020 May 22;9(5). Epub 2020 May 22.

Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

We illuminate a possible explanatory pathophysiologic mechanism for retinal cellular neuropathy by means of a novel diagnostic method using ophthalmoscopic imaging and a molecular imaging agent targeted to fast axonal transport. The retinal neuropathies are a group of diseases with damage to retinal neural elements. Retinopathies lead to blindness but are typically diagnosed late, when substantial neuronal loss and vision loss have already occurred. Read More

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http://dx.doi.org/10.3390/cells9051298DOI Listing

Adverse ocular effects to systemic drug therapy

Orv Hetil 2020 06;161(23):951-961

Általános Orvostudományi Kar, Szemészeti Klinika,Semmelweis Egyetem Budapest, Üllői út 26., 1085.

Systemic medications of various diseases can have adverse effects on the eye that range from asymptomatic lesions to potentially blinding complications such as toxic retinopathy and optic neuropathy. In the course of ophthalmological screening, with the early detection of toxic effects, the majority of drug-induced eye disorders can be prevented and even be reversed. Our review focuses on major drugs with common and significant ocular side effects. Read More

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http://dx.doi.org/10.1556/650.2020.31723DOI Listing

Clinicopathological Correlates: Chronic Arsenic Toxicity Causing Bilateral Symmetric Progressive Optic Neuropathy.

J Neuroophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Departments of Ophthalmology and Vision Sciences (PF, EM), and Medical Imaging (LA-S), Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Biomedical Physics (GM), Ryerson University, Toronto, Canada; Department of Laboratory Medicine (DH), University of Toronto, Toronto, Canada.

A 70 year-old man presented with insidiously progressing central visual acuity loss in both eyes over several years. Objectively the only abnormality identified on the exam was questionable granularity in the fovea in each eye. Extensive work up which included neuro-imaging, screening blood work for toxic and nutritional causes of optic neuropathy as well as electroretinogram and fluorescein angiography to rule out subtle maculopathy was all unrevealing. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000961DOI Listing

Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature.

Indian J Crit Care Med 2020 Mar;24(3):203-205

Department of Pharmacology, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Aim: To determine the significance of acute disulfiram poisoning in pediatric population.

Background: Disulfiram poisoning in children is uncommon, can occur in children who have ingested large amount of drug because of careless and unsafe storage. Only few cases have been reported in literature. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225768PMC

Approaches to measure paediatric chemotherapy-induced peripheral neurotoxicity: a systematic review.

Lancet Haematol 2020 May;7(5):e408-e417

Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

In children who receive neurotoxic chemotherapy, peripheral neurotoxicity occurs frequently, necessitates dose reduction or treatment cessation, and affects function and long-term quality of life. No treatments exist for peripheral neurotoxicity and few assessment measures are specific to children. We did a systematic review to analyse the published literature concerning the evaluation of assessment measures for paediatric chemotherapy-induced peripheral neurotoxicity. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30064-8DOI Listing

Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders.

Neuropsychiatr Dis Treat 2020 15;16:977-984. Epub 2020 Apr 15.

Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People's Republic of China.

Purpose: We summarized the clinical manifestations, laboratory and electrodiagnostic characteristics and magnetic resonance imaging (MRI) findings of nitrous oxide (NO) abuse-induced neurological disorders.

Patients And Methods: We retrospectively reviewed 33 patients with NO abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, nerve conduction studies, together with spinal and brain MRI.

Results: The most frequent clinical manifestations included numbness and weakness in the extremities and unspecified gait disturbance. Read More

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http://dx.doi.org/10.2147/NDT.S236939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167281PMC

The protective effects of moscatilin against methylglyoxal-induced neurotoxicity via the regulation of p38/JNK MAPK pathways in PC12 neuron-like cells.

Food Chem Toxicol 2020 Jun 20;140:111369. Epub 2020 Apr 20.

Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County, 90741, Taiwan. Electronic address:

Methylglyoxal (MGO) is an endogenous toxic compound that plays a vital role in diabetic complications such as diabetic neuropathy. Moscatilin is a bibenzyl component from Dendrobium species, has been shown to possess a wide range of pharmacological activities. To clarify whether moscatilin prevents rat pheochromocytoma cells (PC12 cells) from damage induced by MGO, cells were pre-treated with moscatilin and then stimulated with MGO. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111369DOI Listing

Successful liver transplantation in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

Mol Genet Metab 2020 May 6;130(1):58-64. Epub 2020 Mar 6.

Department of Pediatrics, Section of Genetics and Metabolism, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a fatal disorder characterized by progressive gastrointestinal dysmotility, peripheral neuropathy, leukoencephalopathy, skeletal myopathy, ophthalmoparesis, and ptosis. MNGIE stems from deficient thymidine phosphorylase activity (TP) leading to toxic elevations of plasma thymidine. Hematopoietic stem cell transplant (HSCT) restores TP activity and halts disease progression but has high transplant-related morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.ymgme.2020.03.001DOI Listing
May 2020
2.625 Impact Factor

Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes - Possible Link.

Curr Neuropharmacol 2020 Mar 8. Epub 2020 Mar 8.

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432. Russian Federation.

There is increasing number of the patients worldwide with sleep disturbances and diabetes. Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous causes, may increase the risk of diabetes. Some symptoms of diabetes, such as painful peripheral neuropathy and nocturia, or associated other sleep disorders, such as sleep breathing disorders or sleep movement disorders, may influence the sleep quality and quantity. Read More

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http://dx.doi.org/10.2174/1570159X18666200309101750DOI Listing

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.

N Engl J Med 2020 03;382(10):893-902

From the Clinical HIV Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg (F.C., N.N., P.H.), Sizwe Tropical Disease Hospital, Sandringham (F.C., P.H.), Task Applied Science and Stellenbosch University, Cape Town (A.H.D.), King DiniZulu Hospital Complex, Durban (N.N.), and the TB Alliance, Pretoria (C.V.N., M.O.) - all in South Africa; the TB Alliance, New York (D.E., C.M.M., E.E., J.M., J.T., M.L., M.S.); and the MRC Clinical Trials Unit at UCL (A.M.C., G.H.W.) and the UCL Centre for Clinical Microbiology (T.D.M., A.B., R.H.), University College London, London.

Background: Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically have had poor outcomes.

Methods: In an open-label, single-group study in which follow-up is ongoing at three South African sites, we investigated treatment with three oral drugs - bedaquiline, pretomanid, and linezolid - that have bactericidal activity against tuberculosis and to which there is little preexisting resistance. We evaluated the safety and efficacy of the drug combination for 26 weeks in patients with extensively drug-resistant tuberculosis and patients with multidrug-resistant tuberculosis that was not responsive to treatment or for which a second-line regimen had been discontinued because of side effects. Read More

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http://dx.doi.org/10.1056/NEJMoa1901814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955640PMC

Elemental mercury intoxication in 7 patients admitted to a pediatric rheumatology clinic.

Turk J Pediatr 2019 ;61(5):786-790

Departments of Pediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Paç Kısaarslan A, Sözeri B, Baştuğ F, Gündüz Z, Yel S, Nalçacıoğlu H, Şahin N, Özdemir Çiçek S, Poyrazoğlu H, Düşünsel R. Elemental mercury intoxication in 7 patients admitted to a pediatric rheumatology clinic. Turk J Pediatr 2019; 61: 786-790. Read More

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http://dx.doi.org/10.24953/turkjped.2019.05.021DOI Listing
January 2019

[Diagnostics of polyneuropathies].

Authors:
D Heuß

Internist (Berl) 2020 Mar;61(3):235-242

Neurologische Klinik, Universitätsklinikum Erlangen, Erlangen, Deutschland.

The diagnosis of polyneuropathy (PNP) is based on the anamnesis and description of complaints of the patient and clinical findings. The type of distribution as well as known diseases and drug toxic factors can provide indications. Electromyography and electroneurography can be used to differentiate between axonal and demyelinating PNP. Read More

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http://dx.doi.org/10.1007/s00108-020-00744-wDOI Listing

[Clinical and electrophysiological features and treatment of acrylamide-induced toxic peripheral neuropathy].

Authors:
C W Xu H F Wu J Chen

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Jan;38(1):45-47

Department of Neurology, Jinhua Municipal Central Hospital, Jinhua 321000, China.

To investigate the clinical manifestations, electrophysiology results, treatment and prognosis of acrylamide-induced toxic peripheral neuropathy. The clinical data of 9 patients with acrylamide-induced toxic peripheral neuropathy, who were collected in Jinhua Municipal Central Hospital from January 2015 to August 2018, were retrospectively reviewed. This disease was characterized by distal limb numbness, some patients with hypoalgesia or allergy, deep sense loss, reduction or disappearance of tendon reflexes, and peeling. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2020.01.010DOI Listing
January 2020

Methanol outbreak: a Malaysian tertiary hospital experience.

Int J Emerg Med 2020 Feb 7;13(1). Epub 2020 Feb 7.

National Institute of Health, Shah Alam, Selangor, Malaysia.

Introduction: Methanol poisoning usually occurs in a cluster and initial diagnosis can be challenging. Mortality is high without immediate interventions. This paper describes a methanol poisoning outbreak and difficulties in managing a large number of patients with limited resources. Read More

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http://dx.doi.org/10.1186/s12245-020-0264-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006424PMC
February 2020

Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy.

Pharmaceutics 2020 Feb 3;12(2). Epub 2020 Feb 3.

Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe peripheral neuropathy but confers high anticancer efficacy has not been established. Read More

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http://dx.doi.org/10.3390/pharmaceutics12020125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076355PMC
February 2020

Cobalt toxic optic neuropathy and retinopathy: Case report and review of the literature.

Am J Ophthalmol Case Rep 2020 Mar 25;17:100606. Epub 2020 Jan 25.

Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Purpose: We detail a case of cobalt toxicity with visual and systemic complications, review the pathogenic process for the optic neuropathy and retinopathy, and discuss the controversy of metallic hip prosthesis.

Observations: A 59-year-old female with a history of multiple left hip arthroplasties presented to our clinic with bilateral visual loss. The year prior, she had failure of the hip implant necessitating revision surgery with placement of a chrome-cobalt head. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997813PMC

Diallyl sulfide-induced attenuation of n-hexane-induced peripheral nerve impairment is associated with metabolic inhibition of n-hexane.

Food Chem Toxicol 2020 Mar 30;137:111167. Epub 2020 Jan 30.

Institute of Toxicology, School of Public Health, Shandong University, Jinan, Shandong, 250012, China. Electronic address:

Chronic exposure to n-hexane could induced serious peripheral nerve impairments. It has been well documented that the metabolic activation from n-hexane to 2,5-hexanedione (2,5-HD) is vital in the pathogenesis. Diallyl sulfide (DAS) is an extract of garlic and able to block the bioactivation of xenobiotic. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111167DOI Listing

Autonomic Peripheral Neuropathy.

Authors:
Roy Freeman

Continuum (Minneap Minn) 2020 Feb;26(1):58-71

Purpose Of Review: This article provides a summary of the autonomic neuropathies, including neuropathies associated with diabetes mellitus, neuropathies due to amyloid deposition, immune-mediated autonomic neuropathies (including those associated with a paraneoplastic syndrome), inherited autonomic neuropathies, and toxic autonomic neuropathies. The presenting features, diagnostic investigations, and natural history of these neuropathies are discussed.

Recent Findings: Recent findings in autonomic peripheral neuropathy include data on the epidemiology and atypical presentations of diabetic autonomic neuropathy, treatment-induced neuropathy of diabetes mellitus, the presentation of immune-mediated neuropathies, and advances in hereditary neuropathy associated with amyloidosis and other hereditary neuropathies. Read More

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http://dx.doi.org/10.1212/CON.0000000000000825DOI Listing
February 2020

[Heavy metals in the enviroment: Guillain-Barre like syndrome].

Arch Argent Pediatr 2020 02;118(1):e48-e52

Clínica ambulatoria. Hospital de Pediatría S. A. M. I. C. "Prof. Dr. Juan P. Garrahan".

Guillain-Barré syndrome is an entity of diverse etiology, characterized by acute, symmetric, ascending and progressive muscle weakness, being one of the most frequent acquired polyneuropathies in childhood. Neuropathies produced by heavy metals, mercury and lead, and metalloids, such as arsenic, organophosphorus pesticides and carbon tetrachloride, should be considered among the differential diagnoses. We present a 14-year-old patient with a presumptive diagnosis of Guillain-Barré syndrome without response to conventional treatment with gamma globulin. Read More

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http://dx.doi.org/10.5546/aap.2020.e48DOI Listing
February 2020

[Does the FLOT regimen a new standard of perioperative chemotherapy for localized gastric cancer?]

Bull Cancer 2020 Jan 21;107(1):54-60. Epub 2020 Jan 21.

Institut du cancer de Montpellier, 208, avenue des Apothicaires, 34298 Montpellier, France; IRCM, Inserm, Université Montpellier, ICM, Montpellier, France.

FLOT-4 study recently reports that in patients with gastric cancer, perioperative chemotherapy with 5-fluorouracile, leucovorin, oxaliplatin and docetaxel (FLOT regimen) increases survival over standard ECF/ECX regimen (epirubicine, cisplatine and 5-fluorouracile [or capecitabine]). Does this study, make FLOT a new standard of perioperative chemotherapy for localized gastric cancer? Seven hundred and sixteen patients were included into that randomized study. Thirty seven per cent and 46% of the patients received the full planned treatment in the ECF/ECX group and in the FLOT group, respectively. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.12.005DOI Listing
January 2020

GINGIVAL ULCERATIONS IN A PATIENT WITH ACUTE MYELOID LEUKEMIA: A case report and literature review.

Acta Clin Croat 2019 Sep;58(3):556-560

1Department of Oral Medicine, School of Dental Medicine, University of Zagreb; 2Department of Oral Diseases, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Hematology, School of Medicine and Zagreb University Hospital Centre, Zagreb, Croatia; 4Croatian Bone Marrow Donor Registry, Zagreb University Hospital Centre, Zagreb, Croatia.

A 40-year-old female patient was admitted to the Department of Oral Medicine due to oral ulcerations. Oral ulcerations were present on vestibular mucosa above teeth 21, 22, 25 and 26 and were 1 cm in diameter, and also around teeth 45 and 46. The patient had prolonged neutropenia due to therapy-related myelodysplastic syndrome that progressed to therapy-related acute myeloid leukemia. Read More

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http://dx.doi.org/10.20471/acc.2019.58.03.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971802PMC
September 2019

Molecular Mechanisms of Bortezomib Action: Novel Evidence for the miRNA-mRNA Interaction Involvement.

Int J Mol Sci 2020 Jan 5;21(1). Epub 2020 Jan 5.

Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.

Bortezomib is an anti-tumor agent, which inhibits 26S proteasome degrading ubiquitinated proteins. While apoptotic transcription-associated activation in response to bortezomib has been suggested, mechanisms related to its influence on post-transcriptional gene silencing mediated regulation by non-coding RNAs remain not fully elucidated. In the present study, we examined changes in global gene and miRNA expression and analyzed the identified miRNA-mRNA interactions after bortezomib exposure in human neuroblastoma cells to define pathways affected by this agent in this type of cells. Read More

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http://dx.doi.org/10.3390/ijms21010350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981510PMC
January 2020

Tobacco-Alcohol Toxic Optic Neuropathy.

Rom J Ophthalmol 2019 Oct-Dec;63(4):403-405

"Carol Davila" University of Medicine and Pharmacy Bucharest, Romania.

To present the case of a 34-year-old man with sudden bilateral decrease of visual acuity, followed by a complete and fast recovery. We reported a case of an apparently healthy 34-year-old patient with sudden and unpainful decrease of visual acuity, presumed of toxic etiology. The patient was treated at the debut of the symptomatology, thus having a favorable evolution during hospitalization, with the full recovery of his visual acuity, without complications. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943287PMC

Optic atrophy in children: Current causes and diagnostic approach.

Eur J Ophthalmol 2020 Jan 7:1120672119899378. Epub 2020 Jan 7.

NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.

Background/aims: Optic atrophy is one of the leading causes of sight impairment in children. It frequently poses a diagnostic challenge, as it can be caused by many ocular and systemic conditions. We aimed to determine the current causes of optic atrophy at our centre and to describe the use of investigations, including molecular genetic testing. Read More

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http://dx.doi.org/10.1177/1120672119899378DOI Listing
January 2020

[Small fibre neuropathy: A review].

Semergen 2019 Dec 30. Epub 2019 Dec 30.

Medicina Familiar y Comunitaria, Area Básica de Salud Poblenou, Institut Català de la Salut, Barcelona, España.

Small fibre neuropathy is a disorder of the peripheral nervous system for which main clinical manifestation is chronic neuropathic pain, often accompanied by alterations of the autonomic nervous system. This disease affects the small diameter myelinated (Aδ) and non-myelinated nerve fibres (C). Its causes are primary or secondary, such as metabolism defects, infection, and autoimmune, neurological or toxic diseases, among others. Read More

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http://dx.doi.org/10.1016/j.semerg.2019.11.003DOI Listing
December 2019

Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain.

Sci Rep 2019 12 30;9(1):20324. Epub 2019 Dec 30.

Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

Chemotherapy induced peripheral neuropathy (CIPN), a toxic side effect of some cancer treatments, negatively impacts patient outcomes and drastically reduces survivor's quality of life (QOL). Uncovering the mechanisms driving chemotherapy-induced CIPN is urgently needed to facilitate the development of effective treatments, as currently there are none. Observing that C57BL/6 (B6) and 129SvEv (129) mice are respectively sensitive and resistant to Paclitaxel-induced pain, we investigated the involvement of the gut microbiota in this extreme phenotypic response. Read More

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http://dx.doi.org/10.1038/s41598-019-56832-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937259PMC
December 2019

Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts.

Cancer Drug Resist 2019 19;2:1153-1163. Epub 2019 Dec 19.

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA.

Our genomic DNA is under constant assault from endogenous and exogenous sources, which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1) catalyzes the hydrolysis of phosphodiester bonds that covalently link adducts to DNA-ends. Tdp1 utilizes two catalytic histidines to resolve a growing list of DNA-adducts. Read More

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http://dx.doi.org/10.20517/cdr.2019.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929713PMC
December 2019

Bilateral Optic Disc Edema in a Patient with Lead Poisoning.

J Ophthalmic Vis Res 2019 Oct-Dec;14(4):513-517. Epub 2019 Oct 24.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: Heavy metals, such as lead can cause optic neuropathy. Optic disc neuropathy due to lead intoxication has previously been reported. We report a rare case of lead toxicity-induced optic neuropathy presenting with bilateral hemorrhagic optic disc swelling. Read More

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http://dx.doi.org/10.18502/jovr.v14i4.5465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825703PMC
October 2019

Toxic Optic Neuropathy From Quinine Overdose.

J Neuroophthalmol 2020 Jun;40(2):258-261

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.

A 45-year-old man presented with longstanding poor vision in both eyes. His medical history was significant for a remote overdose of quinine. After the ingestion, he fell into a coma and on awakening was not able to see light out of both eyes. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000865DOI Listing

Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening.

Bioorg Med Chem 2020 Jan 30;28(1):115234. Epub 2019 Nov 30.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8, Lavrentiev Ave., Novosibirsk 630090, Russian Federation. Electronic address:

Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme. The crucial His493 in TDP1's binding site is replaced with an arginine amino acid residue rendering the enzyme dysfunctional. A virtual screen was performed against the homology model of SCAN1 and seventeen compounds were identified and tested in a novel SCAN1 specific biochemical assay. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.115234DOI Listing
January 2020

Ameliorative Effects Of N-Acetylcysteine As Adjunct Therapy On Symptoms Of Painful Diabetic Neuropathy.

J Pain Res 2019 19;12:3147-3159. Epub 2019 Nov 19.

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Purpose: Painful diabetic neuropathy (PDN) is a variant of diabetic peripheral neuropathy which is highly prevalent and distressing in diabetic patients. Despite its high burden, the optimal treatment of PDN has remained a clinical challenge. To explain the emergence and maintenance of PDN, increasing attention has been focused on dimensions of inflammation and oxidative toxic stress (OTS). Read More

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http://dx.doi.org/10.2147/JPR.S228255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875491PMC
November 2019

Study of the possible synergistic protective effects of Melatonin and Pregabalin in Vincristine induced peripheral neuropathy Wistar Albino rats.

Life Sci 2020 Mar 7;244:117095. Epub 2019 Dec 7.

Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.

Aims: Investigate Melatonin administration along with Vincristine (VCR) owing to two reasons: First, Melatonin's sciatic nerve protective effect against Chemotherapy Induced Peripheral Neuropathy (CIPN). Second, Vincristine's anticancer work potentiation that may lead to a decrease in its dose and its side effects accordingly.

Main Methods: In vivo and in vitro experiments were conducted in the study. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.117095DOI Listing
March 2020
2.702 Impact Factor

Adverse drug reactions in tuberculosis and management.

Indian J Tuberc 2019 Oct;66(4):520-532

Department of General Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226010, India.

Background: Treatment of drug susceptible tuberculosis (DS-TB) requires regimens containing first line drugs (FLDs') whereas drug resistant tuberculosis (DR-TB) are treated with regimens comprising combination of both second line drugs (SLDs') and few FLDs'. Adverse drug reactions (ADRs') to these anti-tubercular drugs are quite common as they are being used for longer duration. ADRs' may cause associated morbidity and even mortality if not recognized early. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.11.005DOI Listing
October 2019

Modeling chemotherapy induced peripheral neuropathy (CIPN) in vitro: Prospects and limitations.

Exp Neurol 2020 Apr 5;326:113140. Epub 2019 Dec 5.

Department of Neurology, Johns Hopkins Medical School, Baltimore, USA. Electronic address:

Neuronal cell cultures have been used as an essential tool for studying pathomechanisms of toxicity of chemotherapeutic drugs and to develop neuroprotective approaches. They offer the opportunity to dissect disease mechanisms and molecular pathways while allowing precise control of a variety of confounding factors of the physio-chemical environment. As such, a growing number of in vitro studies are published each year to decipher mechanisms of neurotoxicity of taxanes, vinca alcaloids, proteasome inhibitors and platin derivatives and/or to test neuroprotective strategies. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.113140DOI Listing

Preclinical and clinical research on the toxic and neurological effects of cassava (Manihot esculenta Crantz) consumption.

Metab Brain Dis 2020 01 4;35(1):65-74. Epub 2019 Dec 4.

Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa, 91000, Veracruz, Mexico.

Cassava (Manihot esculenta Crantz) is a tropical plant that is used as fresh food, processed food, or raw material for the preparation of flours with high nutritional value. However, cassava contains cyanogenic glycosides, such as linamarin and lotaustralin, that can trigger severe toxic effects and some neurological disorders, including motor impairment, cognitive deterioration, and symptoms that characterize tropical ataxic neuropathy and spastic epidemic paraparesis (Konzo). These alterations that are associated with the consumption of cassava or its derivatives have been reported in both humans and experimental animals. Read More

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http://dx.doi.org/10.1007/s11011-019-00522-0DOI Listing
January 2020

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial.

Lancet 2019 12 29;394(10214):2084-2095. Epub 2019 Nov 29.

University College London Cancer Institute, and University College London Hospitals, London, UK.

Background: Carboplatin and paclitaxel administered every 3 weeks is standard-of-care first-line chemotherapy for epithelial ovarian cancer. The Japanese JGOG3016 trial showed a significant improvement in progression-free and overall survival with dose-dense weekly paclitaxel and 3-weekly carboplatin. In this study, we aimed to compare efficacy and safety of two dose-dense weekly regimens to standard 3-weekly chemotherapy in a predominantly European population with epithelial ovarian cancer. Read More

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http://dx.doi.org/10.1016/S0140-6736(19)32259-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902268PMC
December 2019

Current Diagnosis and Treatment of Painful Small Fiber Neuropathy.

Authors:
Khosro Farhad

Curr Neurol Neurosci Rep 2019 11 26;19(12):103. Epub 2019 Nov 26.

Department of Neurology at Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WAC 835, Boston, MA, 02114, USA.

Purpose Of Review: Small fiber neuropathy (SFN) could cause significant morbidity due to neuropathic pain and autonomic dysfunction. SFN is underdiagnosed and the knowledge on the condition is limited among general public and health care professionals. This review is intended to enhance the understanding of SFN symptoms, causes, diagnostic tools, and therapeutic options. Read More

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http://dx.doi.org/10.1007/s11910-019-1020-1DOI Listing
November 2019
4 Reads

Radiation induced optic neuropathy: Does treatment modality influence the risk?

Bull Cancer 2019 Dec 19;106(12):1160-1176. Epub 2019 Nov 19.

Centre François-Baclesse/ARCHADE, Department of Radiation Oncology, 3, avenue General Harris, 14000 Caen, France; Unicaen - Normandie Université, laboratoire de physique corpusculaire IN2P3/ENSICAEN - UMR6534, boulevard du Marechal Juin, 14050 Caen, France.

Radiation induced optic neuropathy (RION) is a rare but disastrous complication of radiation therapy in treatment of periorbital tumors. The objective of this study is to investigate the incidence of RION in series of patients treated from peri orbital tumors by recent photon and proton irradiation modalities. We searched the Pub Med database for studies in periorbital tumors including base of skull, sinonasal, pituitary, nasopharyngeal tumors and craniopharyngioma treated with Intensity modulated radiotherapy (IMRT) and with proton beam therapy (PBT) between 1992 and 2017 excluding metastatic tumors, lymphomas, pediatric series, those treated mainly with chemotherapy, target therapy and those written in languages other than English and French. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.09.008DOI Listing
December 2019
0.635 Impact Factor

[Mitochondrial biogenesis in hereditary optic neuropathies].

Vestn Oftalmol 2019 ;135(5):85-91

Research Centre for Medical Genetics, 1 Moskvorech'e St., Moscow, Russian Federation, 115522.

The article offers a review of mitochondrial biogenesis in hereditary optic neuropathies. It covers the mechanisms of mitochondrial biogenesis, factors affecting it and tools for mitochondrial turnover assessment. Read More

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http://dx.doi.org/10.17116/oftalma201913505185DOI Listing
November 2019

Diabetes, diabetic complications, and phosphate toxicity: a scoping review.

Authors:
Ronald B Brown

Curr Diabetes Rev 2019 Nov 3. Epub 2019 Nov 3.

School of Public Health and Health Systems, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

This article presents a scoping review and synthesis of research findings investigating the toxic cellular accumulation of dysregulated inorganic phosphate-phosphate toxicity-as a pathophysiological determinant of diabetes and diabetic complications. Phosphorus, an essential micronutrient, is closely linked to the cellular metabolism of glucose for energy production, and serum inorganic phosphate is often transported into cells along with glucose during insulin therapy. Mitochondrial dysfunction and apoptosis, endoplasmic reticulum stress, neuronal degeneration, and pancreatic cancer are associated with dysregulated levels of phosphate in diabetes. Read More

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http://dx.doi.org/10.2174/1573399815666191104113236DOI Listing
November 2019
1 Read

Toxic inoculation associated with a presumptive stingray injury.

Undersea Hyperb Med 2019 Sep - Dec - Fourth Quarter;46(5):719-722

Long Beach Memorial Medical Center.

Introduction: Stingray spine injuries are among the most common marine animal injuries in humans. While most resolve with immersion in warm water, a few become infected and require antibiotics. We present a case report of a presumptive stingray injury that evolved to a major slough and which required prolonged healing in a patient with diabetes mellitus. Read More

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November 2019

Evidence that fodipir (DPDP) binds neurotoxic Pt with a high affinity: An electron paramagnetic resonance study.

Sci Rep 2019 11 1;9(1):15813. Epub 2019 Nov 1.

Division of Drug Research/Pharmacology, Linköping University, Linköping, Sweden.

Oxaliplatin typically causes acute neuropathic problems, which may, in a dose-dependent manner, develop into a chronic form of chemotherapy-induced peripheral neuropathy (CIPN), which is associated with retention of Pt in the dorsal root ganglion. A clinical study by Coriat and co-workers suggests that co-treatment with mangafodipir [Manganese(II) DiPyridoxyl DiPhosphate; MnDPDP] cures ongoing CIPN. These authors anticipated that it is the manganese superoxide dismutase mimetic activity of MnDPDP that explains its curative activity. Read More

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http://dx.doi.org/10.1038/s41598-019-52248-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825159PMC
November 2019

Chemotherapy-induced peripheral neurotoxicity: A multifaceted, still unsolved issue.

J Peripher Nerv Syst 2019 10;24 Suppl 2:S6-S12

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a potentially dose-limiting side effect of several commonly used cytotoxic chemotherapy agents. The main pharmacological classes that may cause CIPN include classical anticancer drugs, as well as the recently introduced immune checkpoint inhibitors and antibody drug conjugates. The absence of a complete knowledge of CIPN pathophysiology is only one of the several unsolved issues related to CIPN. Read More

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http://dx.doi.org/10.1111/jns.12337DOI Listing
October 2019

The Toxic Neuropathy Consortium of the Peripheral Nerve Society.

J Peripher Nerv Syst 2019 10;24 Suppl 2:S4-S5

Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/jns.12331DOI Listing
October 2019
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Targeting Inflammatory Processes Mediated by TRPVI and TNF-α for Treating Noise-Induced Hearing Loss.

Front Cell Neurosci 2019 3;13:444. Epub 2019 Oct 3.

Department of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL, United States.

Noise trauma is the most common cause of hearing loss in adults. There are no known FDA approved drugs for prevention or rescue of noise-induced hearing loss (NIHL). In this study, we provide evidence that implicates stress signaling molecules (TRPV1, NOX3, and TNF-α) in NIHL. Read More

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http://dx.doi.org/10.3389/fncel.2019.00444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786284PMC
October 2019
1 Read
4.289 Impact Factor

Guillain-Barré Syndrome During Platinum-Based Chemotherapy: A Case Series and Review of the Literature.

Oncologist 2020 01 15;25(1):e194-e197. Epub 2019 Oct 15.

Assistance Publique Hôpitaux de Paris (APHP), Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2-Mazarin et Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), Unité Mixte de Recherche (UMR) S975, Paris, France.

Platinum-based chemotherapy is commonly associated with toxic sensory neuropathies, but also, although rarely, with Guillain-Barré syndrome (GBS). We describe five patients who developed GBS while receiving platinum-based chemotherapy for a solid tumor and report the five cases published so far. Most patients had received cumulative platinum doses below known neurotoxic levels, and all of them had an optimal outcome after platinum discontinuation, associated in most cases with administration of intravenous immunoglobulin. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964130PMC
January 2020
1 Read