1,708 results match your criteria Toxic Neuropathy


Ultrastructure in Transthyretin Amyloidosis: From Pathophysiology to Therapeutic Insights.

Biomedicines 2019 Feb 5;7(1). Epub 2019 Feb 5.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Transthyretin (TTR) amyloidosis is caused by systemic deposition of wild-type or variant amyloidogenic TTR (ATTRwt and ATTRv, respectively). ATTRwt amyloidosis has traditionally been termed senile systemic amyloidosis, while ATTRv amyloidosis has been called familial amyloid polyneuropathy. Although ATTRwt amyloidosis has classically been regarded as one of the causes of cardiomyopathy occurring in the elderly population, recent developments in diagnostic techniques have significantly expanded the concept of this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biomedicines7010011DOI Listing
February 2019
1 Read

Polysaccharides as potential anticancer agents-A review of their progress.

Carbohydr Polym 2019 Apr 29;210:412-428. Epub 2019 Jan 29.

SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.

Cancer is one of the most common diseases seen in developed countries, with over 1.6 million new cases estimated in 2017, in the US alone. The current chemotherapeutic drugs available for the therapeutic management of cancer are associated with major adverse effects like alopecia, anemia, immunodeficiency, fatigue, peripheral neuropathy, fertility issues and neurological problems, to name a few of them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carbpol.2019.01.064DOI Listing
April 2019
1 Read

Treatment and Outcomes in Nutritional Optic Neuropathy.

Curr Treat Options Neurol 2019 Feb 7;21(1). Epub 2019 Feb 7.

Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.

Purpose Of Review: Nutritional optic neuropathy is a potential cause of severe visual loss; however, appropriate and timely management can result in excellent visual outcomes. The purpose of this review is to outline our current understanding of the treatment and outcomes for nutritional optic neuropathy.

Recent Findings: Current understanding of nutritional optic neuropathy has been greatly aided by some well-reported and investigated epidemics of the condition, most notably the Cuban epidemic optic neuropathy of the early 1990s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11940-019-0542-9DOI Listing
February 2019
1 Read

Common Structural Lesions of the Peripheral Nervous System.

Toxicol Pathol 2019 Feb 5:192623319826068. Epub 2019 Feb 5.

1 Virginia Tech-Laboratory for Neurotoxicity Studies, College of Veterinary Medicine, Blacksburg, Virginia, USA.

This review illustrates common lesions of peripheral nerve myelinated fibers that occur in toxic neuropathy. These distinctive structural changes help to define the site of toxicant activity and thus predict the course of neurotoxic disease and recovery. Neuronopathy is the condition where the primary injury is directed to the neuronal cell body giving rise to a peripheral nerve axon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0192623319826068DOI Listing
February 2019

The Efficacy and Safety of First-line Chemotherapies for Advanced Biliary Tract Cancer: A Network Meta-analysis.

J Cancer 2019 1;10(1):257-266. Epub 2019 Jan 1.

Department of Oncology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, China.

Major chemotherapeutic drugs for advanced biliary tract cancer (ABTC) include gemcitabine, fluoropyrimidines and platinum compounds, but the optimum combination of them remains inconclusive. The main objective of this network meta-analysis was to compare the efficacy and safety of first-line chemotherapies for ABTC. We searched PubMed, EMBASE, the Cochrane library and Science Direct for relevant controlled trials until May 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jca.27487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329850PMC
January 2019
2 Reads

Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases.

J Biol Chem 2019 01 14. Epub 2019 Jan 14.

The Scripps Research Institute, United States.

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that catalyze the first reaction in protein biosynthesis, namely, the charging of transfer RNAs (tRNAs) with their cognate amino acids. aaRSs have been increasingly implicated in dominantly and recessively inherited human diseases. The most common aaRS-associated monogenic disorder is the incurable neurodegenerative disease Charcot-Marie-Tooth neuropathy (CMT), caused by dominant mono-allelic mutations in aaRSs. Read More

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.REV118.002955
Publisher Site
http://dx.doi.org/10.1074/jbc.REV118.002955DOI Listing
January 2019
5 Reads

Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Centre for Integrated Preclinical Drug Development, School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia Campus, Brisbane, QLD, 4072, Australia.

Human immuno-deficiency virus (HIV) associated sensory neuropathy (SN) is a frequent complication of HIV infection. It is extremely difficult to alleviate and hence the quality of life of affected individuals is severely and adversely impacted. Stavudine (d4T) is an antiretroviral drug that was widely used globally prior to 2010 and that is still used today in resource-limited settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10787-018-00551-8DOI Listing
January 2019

Enhanced axonal Neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model.

Hum Mol Genet 2018 Nov 27. Epub 2018 Nov 27.

DIBIT, Divisions of Genetics and Cell Biology.

Charcot-Marie-Tooth neuropathies (CMTs) are a group of genetic disorders that affect the peripheral nervous system (PNS) with heterogeneous pathogenesis and no available treatment. Axonal Neuregulin 1 type III (Nrg1TIII) drives peripheral nerve myelination by activating downstream signaling pathways such as PI3K/Akt and MAPK/Erk that converge on master transcriptional regulators of myelin genes, such as Krox20. We reasoned that modulating Nrg1TIII activity may constitute a general therapeutic strategy to treat CMTs that are characterized by reduced levels of myelination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddy411DOI Listing
November 2018
4 Reads

Alcohol-related peripheral neuropathy: a systematic review and meta-analysis.

J Neurol 2018 Nov 22. Epub 2018 Nov 22.

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.

The primary aim of this systematic review was to establish the prevalence, character, and risk factors of peripheral neuropathy amongst chronic alcohol abusers and to identify the most appropriate management strategies. In this review, possible pathogenetic mechanisms are also discussed. A systematic, computer-based search was conducted using the PubMed database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-018-9123-1DOI Listing
November 2018
11 Reads

Anthracycline and taxane-based chemotherapy versus docetaxel and cyclophosphamide in the adjuvant treatment of HER2-negative breast cancer patients: a systematic review and meta-analysis of randomized controlled trials.

Breast Cancer Res Treat 2018 Nov 21. Epub 2018 Nov 21.

Department of Medical Oncology, Institut Jules Bordet and Université Libre de Bruxelles (ULB), Boulevard de Waterloo 121, 1000, Brussels, Belgium.

Purpose: Standard adjuvant chemotherapy for HER2-negative breast cancer consists generally in an anthracycline and taxane-based regimen (A+T). The TC (docetaxel and cyclophosphamide) regimen arises as a potential alternative, although individual randomized controlled trials (RCTs) could not demonstrate the non-inferiority of TC over A+T. This is a systematic review and meta-analysis of RCTs comparing 6 cycles of TC versus sequential A+T in the adjuvant treatment of HER2-negative breast cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-018-5055-9DOI Listing
November 2018
17 Reads

Chronic Neurologic Effects of Alcohol.

Clin Liver Dis 2019 Feb;23(1):141-155

Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, 7200 Cambridge Street, 9th Floor, MS:BCM609, Houston, TX 77030, USA. Electronic address:

Chronic alcohol use induces silent changes in the structure and function of the central and peripheral nervous systems that eventually result in irreversible, debilitating repercussions. Once identified, nutritional supplementation and cessation measures are critical in preventing further neurologic damage. The proposed mechanisms of neuronal injury in chronic alcohol abuse include direct toxic effects of alcohol and indirect effects, including those resulting from hepatic dysfunction, nutritional deficiencies, and neuroinflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cld.2018.09.010DOI Listing
February 2019
2 Reads

Clinical and genetic determinants of chronic visual pathway changes after methanol - induced optic neuropathy: four-year follow-up study.

Clin Toxicol (Phila) 2018 Nov 17:1-11. Epub 2018 Nov 17.

a Toxicological Information Centre, Department of Occupational Medicine, First Faculty of Medicine , Charles University and General University Hospital , Prague , Czech Republic.

Context: Methanol poisoning induces acute optic neuropathy with possible long-term visual damage.

Objective: To study the dynamics and key determinants of visual pathway functional changes during 4 years after acute methanol poisoning.

Methods: A total of 42 patients with confirmed methanol poisoning (mean age 45. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2018.1532083DOI Listing
November 2018
4 Reads

Regulatory Mechanisms of the Wnt/β-Catenin Pathway in Diabetic Cutaneous Ulcers.

Front Pharmacol 2018 17;9:1114. Epub 2018 Oct 17.

Pharmacy Department, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Skin ulcers are a serious complication of diabetes. Diabetic patients suffer from vascular lesions and complications such as peripheral neuritis, peripheral vascular lesions, and collagen abnormalities, which result in skin wounds that are refractory and often develop into chronic ulcers. The healing of skin ulcers requires an inflammatory reaction, wound proliferation, remodeling regulation, and control of stem cells. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fphar.2018.01114
Publisher Site
http://dx.doi.org/10.3389/fphar.2018.01114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199358PMC
October 2018
4 Reads

The conceptual introduction of the "demyelinating Schwann cell" in peripheral demyelinating neuropathies.

Glia 2018 Oct 30. Epub 2018 Oct 30.

INSERM U1051, Institut des Neurosciences de Montpellier (INM), Université de Montpellier, Montpellier, France.

Myelinating Schwann cells undergo irreversible demyelination in many demyelinating neuropathies that show complete demyelination of the internode. Dedifferentiation, reprogramming, and myelin clearance processes-which are specifically discussed in this article-appear to be shared by various demyelinating peripheral conditions, such as Wallerian degeneration, immune-mediated, and toxic demyelinating diseases. We propose to introduce the concept of the "demyelinating Schwann cell (DSC)" as a novel cell phenotype, which has specific properties required for myelin sheath clearance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.23509DOI Listing
October 2018
3 Reads

The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: an experimental study.

Cutan Ocul Toxicol 2018 Nov 26:1-5. Epub 2018 Nov 26.

d Department of Biochemistry , Atatürk University , Erzurum , Turkey.

Aim: Ethambutol and isoniazid are two major effective first line agents in tuberculosis treatment having some visual adverse effects. We aimed to determine the protective effects of lutein on oxidative optic neuropathy induced by ethambutol and isoniazid in an experimental model.

Material And Method: Totally 24 albino Wistar male rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group), 50 mg/kg ethambutol +50 mg/kg isoniazid administered group (EI), 0. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
Publisher Site
http://dx.doi.org/10.1080/15569527.2018.1539010DOI Listing
November 2018
10 Reads
0.920 Impact Factor

Unraveling the Role of Heme in Neurodegeneration.

Front Neurosci 2018 9;12:712. Epub 2018 Oct 9.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.

Heme (iron-protoporphyrin IX) is an essential co-factor involved in several biological processes, including neuronal survival and differentiation. Nevertheless, an excess of free-heme promotes oxidative stress and lipid peroxidation, thus leading to cell death. The toxic properties of heme in the brain have been extensively studied during intracerebral or subarachnoid hemorrhages. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fnins.2018.00712
Publisher Site
http://dx.doi.org/10.3389/fnins.2018.00712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189481PMC
October 2018
10 Reads

Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3β-dependent pathway.

Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418805322

1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.

Acrylamide (ACR), formed during the Maillard reaction induced by high temperature in food processing, is one of the main causes of neurodegenerative diseases. Taurine, a free intracellular β-amino acid, is characterized by many functions, including antioxidation, anti-inflammatory, and neuroprotective properties. This promotes its application in the treatment of neurodegenerative diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2058738418805322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202743PMC
October 2018
4 Reads

[Role of novel proteasome inhibitors in the treatment of relapsed/refractory multiple myeloma].

Authors:
Masaki Ri

Rinsho Ketsueki 2018;59(10):2162-2168

Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences.

Multiple myeloma (MM) is a mature plasma cell neoplasm characterized by the excessive production of monoclonal antibodies and various cytokines. Therefore, MM cells are highly dependent on the ubiquitin-proteasome pathway and the well-differentiated unfolded protein response in the endoplasmic reticulum. Bortezomib, the first approved proteasome inhibitor (PI) for the treatment of MM, is widely used as a therapeutic agent for patients with MM, including newly diagnosed and relapsed/refractory (RR) cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11406/rinketsu.59.2162DOI Listing
January 2018
1 Read

Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2.

Sci Rep 2018 Oct 5;8(1):14891. Epub 2018 Oct 5.

McClellan Veterans Medical Center, Central Arkansas Veterans Healthcare Service, Little Rock, AR, 72205, USA.

Toxic protein aggregates are key features of progressive neurodegenerative diseases. In addition to "seed" proteins diagnostic for each neuropathy (e.g. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-018-33143-1
Publisher Site
http://dx.doi.org/10.1038/s41598-018-33143-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173753PMC
October 2018
1 Read

PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection.

Pharmacol Res 2018 Nov 29;137:104-113. Epub 2018 Sep 29.

College of Health and Biomedicine, Institute for Health and Sport, Victoria University, Melbourne, Australia; Department of Medicine Western Health, Melbourne University, Melbourne, Australia; Australian Institute of Musculoskeletal Science (AIMSS), Melbourne, Australia. Electronic address:

Cisplatin, carboplatin and oxaliplatin represent the backbone of platinum therapy for several malignancies including head and neck, lung, colorectal, ovarian, breast, and genitourinary cancer. However, the efficacy of platinum-based drugs is often compromised by a plethora of severe toxicities including sensory and enteric neuropathy. Acute and chronic neurotoxicity following platinum chemotherapy is a major constraint, contributing to dose-reductions, treatment delays, and cessation of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2018.09.031DOI Listing
November 2018
1 Read

Circular RNA and Alzheimer's Disease.

Authors:
Rumana Akhter

Adv Exp Med Biol 2018;1087:239-243

Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.

Circular RNAs (circRNAs) represent a special group of noncoding single-stranded highly stable ribonucleic acid entities abundant in the eukaryotic transcriptome. These circular forms of RNAs are significantly enriched in human brain and retinal tissues. However, the biological evolution and function of these circRNAs are poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-13-1426-1_19DOI Listing
February 2019
2 Reads

Sciatic neuropathy caused by a pressure ulcer: A case report.

Medicine (Baltimore) 2018 Sep;97(36):e12254

Rationale: Sciatic neuropathy has various causes; however, cases in which a pressure ulcer led to sciatic neuropathy have not been reported to date.

Patient Concerns: A 33-year-old woman with no pre-existing mobility problems visited our department with the chief complaint of an extensive pressure ulcer and necrosis in her right buttock. She had a medical history of being bedridden for 2 days while in a coma due to a drug overdose 2 months previously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000012254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133460PMC
September 2018
2 Reads

Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis.

J Basic Clin Physiol Pharmacol 2018 Sep 3. Epub 2018 Sep 3.

Maulana Azad Medical College, Department of Pharmacology, New Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/jbcpp-2018-0007DOI Listing
September 2018
10 Reads

Carboplatin/Paclitaxel Induction in Ovarian Cancer: The Finer Points.

Oncology (Williston Park) 2018 08;32(8):418-20, 422-4

The carboplatin/paclitaxel doublet remains the chemotherapy backbone for the initial treatment of ovarian cancer. This two-drug regimen, with carboplatin dosed using the Calvert formula, yielded convincing noninferior outcomes when compared with the prior, more toxic, regimen of cisplatin/paclitaxel. Carboplatin's dose-limiting toxicity is thrombocytopenia; however, when this drug is properly dosed and combined with paclitaxel, the doublet's cycle 1 dose in chemotherapy-naive women is generally safe. Read More

View Article

Download full-text PDF

Source
August 2018
1 Read

Predicting visual function after an ocular bee sting.

Int Ophthalmol 2018 Aug 13. Epub 2018 Aug 13.

West Virginia University Eye Institute, 1 Medical Center Dr, Morgantown, WV, 26506, USA.

Purpose: To report a case of toxic optic neuropathy caused by an ocular bee sting.

Methods: Case report and literature review.

Results: A 44-year-old female presented with no light perception vision 2 days after a corneal bee sting in her right eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-018-0978-zDOI Listing
August 2018
5 Reads

Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity.

Biomed Pharmacother 2018 Nov 8;107:306-328. Epub 2018 Aug 8.

Department of Physiology, University of Gour Banga, Mokdumpur, Malda 732103, India. Electronic address:

Chronic exposure of glucose rich environment creates several physiological and pathophysiological changes. There are several pathways by which hyperglycemia exacerbate its toxic effect on cells, tissues and organ systems. Hyperglycemia can induce oxidative stress, upsurge polyol pathway, activate protein kinase C (PKC), enhance hexosamine biosynthetic pathway (HBP), promote the formation of advanced glycation end-products (AGEs) and finally alters gene expressions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2018.07.157DOI Listing
November 2018
13 Reads

The Antidiabetic Drug Liraglutide Minimizes the Non-Cholinergic Neurotoxicity of the Pesticide Mipafox in SH-SY5Y Cells.

Neurotox Res 2019 Jan 7;35(1):150-159. Epub 2018 Aug 7.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP, Universidade de São Paulo, USP, Avenida do Café s/n, Ribeirão Preto, SP, 14040-903, Brazil.

Organophosphorus (OPs) compounds have been widely used in agriculture, industry, and household, and the neurotoxicity induced by them is still a cause of concern. The main toxic mechanism of OPs is the inhibition of acetylcholinesterase (AChE); however, the delayed neuropathy induced by OPs (OPIDN) is mediated by other mechanisms such as the irreversible inhibition of 70% of NTE activity (neuropathy target esterase) that leads to axonal degeneration. Liraglutide is a long-lasting GLP-1 analog clinically used as antidiabetic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12640-018-9941-zDOI Listing
January 2019
3 Reads

Toxic medications in Leber's hereditary optic neuropathy.

Mitochondrion 2018 Aug 4. Epub 2018 Aug 4.

Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA; Doheny Eye Center, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 800 South Fairmount Avenue, Suite 215, Pasadena, CA 91105, USA; The Ottawa Eye Institute, University of Ottawa, 501 Smyth Rd, Ottawa, ON K1H 8M2, Canada; Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada.

Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder characterized by acute bilateral vision loss. The pathophysiology involves reactive oxygen species (ROS), which can be affected by medications. This article reviews the evidence for medications with demonstrated and theoretical effects on mitochondrial function, specifically in relation to increased ROS production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2018.07.007DOI Listing
August 2018
19 Reads

Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies.

Curr Eye Res 2018 Oct 7;43(10):1199-1204. Epub 2018 Aug 7.

a Department of Ophthalmology , University of California , Irvine , CA , USA.

There is growing evidence for the role of mitochondrial dysfunction in the toxic optic neuropathies. Due to the structural similarities between antibiotic targets and mitochondrial machinery, several antibiotics known to cause optic neuropathy have deleterious effects on mitochondrial function. We review the literature on the prevalence, clinical manifestations, and management of antibiotic induced toxic optic neuropathies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2018.1504086DOI Listing
October 2018
2 Reads

Safety and tolerability of PD-1/PD-L1 inhibitors in the treatment of non-small cell lung cancer: a meta-analysis of randomized controlled trials.

J Cancer Res Clin Oncol 2018 Oct 17;144(10):1851-1859. Epub 2018 Jul 17.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, 610041, China.

Background: Significant improvement in survival outcome with the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors has been shown in advanced non-small cell lung cancer (NSCLC) patients compared with chemotherapy. However, the full spectrum of toxic events of PD-1/PD-L1 inhibitors was not well characterized. We conducted a comprehensive meta-analysis to state the safety profile of PD-1/PD-L1 inhibitors in NSCLC, and identify the exact incidence and relative risk (RR) of both summary and detailed AEs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2707-4DOI Listing
October 2018
5 Reads

Emerging therapies for mitochondrial diseases.

Essays Biochem 2018 07 20;62(3):467-481. Epub 2018 Jul 20.

Department of Neurology, Columbia University Medical Center, New York, NY, U.S.A.

For the vast majority of patients with mitochondrial diseases, only supportive and symptomatic therapies are available. However, in the last decade, due to extraordinary advances in defining the causes and pathomechanisms of these diverse disorders, new therapies are being developed in the laboratory and are entering human clinical trials. In this review, we highlight the current use of dietary supplement and exercise therapies as well as emerging therapies that may be broadly applicable across multiple mitochondrial diseases or tailored for specific disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/EBC20170114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104515PMC
July 2018
7 Reads

Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial.

JAMA Oncol 2018 Oct;4(10):1344-1351

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Preferential delivery of docetaxel to tumors by prostate-specific membrane antigen (PSMA)-targeted nanoparticles is clinically effective, and the selective reduction of PSMA-positive circulating tumor cells (CTCs) after treatment has implications for patient selection and disease monitoring.

Objective: To determine the safety and efficacy of BIND-014, a PSMA-directed docetaxel-containing nanoparticle, in patients with metastatic castration-resistant prostate cancer (mCRPC).

Design, Setting, And Participants: A multicenter open-label, phase 2 clinical trial of 42 chemotherapy-naive patients with progressing mCRPC after treatment with abiraterone acetate and/or enzalutamide was conducted from June 24, 2013, to June 10, 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2018.2168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233779PMC
October 2018
7 Reads

Macular ganglion cell complex measurement in bilateral retrobulbar optic neuropathy without a relative afferent pupillary defect.

Int Med Case Rep J 2018 25;11:145-150. Epub 2018 Jun 25.

Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan,

Purpose: This study aimed to demonstrate the clinical usefulness of measuring the macular ganglion cell complex (GCC) for the early detection of axonal loss in eyes with bilateral retrobulbar optic neuropathies.

Patients And Methods: We retrospectively reviewed the medical records of three patients with bilateral toxic, ischemic, or infiltrative retrobulbar optic neuropathy.

Results: No relative afferent pupillary defect was detected in any patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IMCRJ.S160417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022815PMC
June 2018
8 Reads

Steroid Treatment of Optic Neuropathies.

Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.

The etiologies of optic neuropathy include inflammation, ischemia, toxic and metabolic injury, genetic disease, and trauma. There is little controversy over the practice of using steroids in the treatment of optic neuritis--it is well established that intravenous steroid treatment can speed visual recovery but does not alter final visual function. However, there is controversy surrounding the acceptable routes of administration, dosage, and course of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22608/APO.2018127DOI Listing
August 2018
4 Reads

Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation.

J Hematol Oncol 2018 Jun 28;11(1):87. Epub 2018 Jun 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, WA, USA.

Background: Mantle cell lymphoma (MCL) is an aggressive and incurable lymphoma. Standard of care for younger patients with MCL is induction chemotherapy followed by autologous stem cell transplantation (auto-HCT). Rituximab maintenance after auto-HCT has been shown to improve progression-free survival (PFS) and overall survival (OS) in MCL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13045-018-0631-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022297PMC
June 2018
10 Reads

Predictive validity of pharmacologic interventions in animal models of neuropathic pain.

Scand J Pain 2011 Oct 1;2(4):178-184. Epub 2011 Oct 1.

Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Introduction The pathophysiologic and neurochemical characteristics of neuropathic pain must be considered in the search for new treatment targets. Breakthroughs in the understanding of the structural and biochemical changes in neuropathy have opened up possibilities to explore new treatment paradigms. However, long term sequels from the damage are still difficult to treat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sjpain.2011.06.002DOI Listing
October 2011
6 Reads

Determinants of anti-retroviral regimen changes among HIV/AIDS patients of east and west Wollega zone health institutions, Oromia region, west Ethiopia: a cross-sectional study.

BMC Pharmacol Toxicol 2018 06 5;19(1):28. Epub 2018 Jun 5.

Wollega University, Nekemte, Ethiopia.

Background: Human Immunodeficiency Virus (HIV) is one of the main causes of morbidity and mortality; because of this it continues to be a major global public health concern. It has believed to kill more than 34 million lives so far. Sub Saharan Africa constitutes about 70% of people living with HIV among the 37 million on the globe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40360-018-0220-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989450PMC

Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study.

Int J Ophthalmol 2018 18;11(5):780-785. Epub 2018 May 18.

Department of Pharmacology, Erzincan University Hospital, College of Medicine, Erzincan 24100, Turkey.

Aim: To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ethanol.

Methods: Totally 30 rats were divided into 5 groups, with 6 rats in each group as follows: healthy controls (C), methotrexate (MTX), methotrexate+methanol (MTM), methotrexate+methanol+ethanol (MTME) and methotrexate+ methanol+Rutin (MTMR). In all rabbits except those of the control group, MTX, diluted in sterile serum physiologic, 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18240/ijo.2018.05.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957028PMC
May 2018
16 Reads
0.500 Impact Factor

Vitamin B deficiency-induced neuropathy secondary to prolonged recreational use of nitrous oxide.

Am J Emerg Med 2018 Sep 24;36(9):1717.e1-1717.e2. Epub 2018 May 24.

Beth Israel, United States. Electronic address:

A 24-year-old female, otherwise healthy, presented to the Emergency Department (ED) with difficulty walking and bilateral leg pain. The patient was a recreational nitrous oxide (NO) user, also known as "whippets" or simply nitrous. Neurologic examination demonstrated an unsteady gait and positive Romberg sign along with normal deep tendon reflexes and normal muscle strength in upper and lower extremities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2018.05.029DOI Listing
September 2018
21 Reads

Phase II study of panitumumab combined with capecitabine and oxaliplatin as first-line treatment in metastatic colorectal cancer patients: clinical results including extended tumor genotyping.

Med Oncol 2018 May 31;35(7):101. Epub 2018 May 31.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

This clinical trial assessed the efficacy and toxicity of panitumumab combined with oxaliplatin and capecitabine as first-line treatment in KRAS exon 2 wild-type metastatic colorectal cancer (mCRC) patients. Patients with exon 2 KRAS wild-type mCRC received panitumumab 9 mg/Kg, oxaliplatin 130 mg/m, and capecitabine 2000 mg/m repeated every 3 weeks. The primary endpoint was objective response rate (ORR, minimum 42 responses). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12032-018-1160-1DOI Listing
May 2018
8 Reads

Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes.

JAMA Neurol 2018 Aug;75(8):980-988

Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Importance: In light of the excellent long-term survival of childhood cancer patients, it is imperative to screen for factors affecting health, function, and quality of life in long-term survivors.

Objective: To comprehensively assess chemotherapy-induced peripheral neuropathy in childhood cancer survivors to define disease burden and functional effect and to inform screening recommendations.

Design, Setting, And Participants: In this cross-sectional observational study, cancer survivors who were treated with chemotherapy for extracranial malignancy before age 17 years were recruited consecutively between April 2015 and December 2016 from a single tertiary hospital-based comprehensive cancer survivorship clinic and compared with healthy age-matched controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2018.0963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142928PMC

The Superoxide Dismutase Mimetic TEMPOL and Its Effect on Retinal Ganglion Cells in Experimental Methanol-Intoxicated Rats.

Ophthalmol Ther 2018 Jun 24;7(1):167-172. Epub 2018 May 24.

Ophthalmology Department, Universitas Padjadjaran, Bandung, Indonesia.

Introduction: The incidence of blindness due to methanol intoxication is higher in males of productive age. The management of methanol-induced toxic optic neuropathy is yet to produce satisfactory results. Antioxidant therapy is now used as an alternative method of preventing methanol intoxication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40123-018-0132-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997599PMC
June 2018
1 Read

Cuban Epidemic Neuropathy: Insights into the Toxic-Nutritional Hypothesis through International Collaboration.

MEDICC Rev 2018 Apr;20(2):27-31

Neurology and Neurosurgery Institute, Havana, Cuba.

From 1991 to 1993, an epidemic of optic and peripheral neuropathy-the largest of the century-broke out in Cuba, affecting more than 50,000 people. Initially the main clinical features were decreased visual acuity, central and cecocentral scotomas, impaired color vision and absence of the papillomacular bundle. Later, peripheral and mixed optic-peripheral forms began to appear. Read More

View Article

Download full-text PDF

Source
April 2018
5 Reads

Study of the Efficiency of the Hydroporation for Delivery of Plasmid DNA to the Cells on the Model of Toxic Neuropathy.

Bull Exp Biol Med 2018 Apr 27;164(6):798-802. Epub 2018 Apr 27.

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.

We compared the efficiency of delivery of plasmid DNA (active ingredient concentration 1 mg/kg) that provides production of nerve growth factor (NGF) after intravenous administration to rats and after administration by hydroporation. The method of hydroporation ensured plasmid penetration into the liver tissue and lengthened the time of its detection in the organ. DNA concentration in 1 h after its introduction by hydroporation or intravenous route was 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10517-018-4083-0DOI Listing

Risk factors for the development of paclitaxel-induced neuropathy in breast cancer patients.

J Peripher Nerv Syst 2018 Jun 11;23(2):129-133. Epub 2018 May 11.

Department of Neurology, University of Minnesota, Minneapolis, Minnesota.

Peripheral neuropathy is a common side effect of many chemotherapeutic agents including paclitaxel. We prospectively evaluated demographic and laboratory data in a cohort of 61 woman with breast cancer prior to paclitaxel exposure to explore factors that predispose to neuropathy development. Neuropathy was graded based on the total neuropathy score reduced version (rTNS) at baseline and at 4 months after initiation of chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jns.12271DOI Listing
June 2018
3 Reads

Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry.

Cutan Ocul Toxicol 2018 Dec 24;37(4):319-323. Epub 2018 Apr 24.

a Department of General Ophthalmology , Medical University , Lublin , Poland.

Purpose: To measure the area of central scotoma obtained with semi-automated kinetic perimetry (SKP) in patients suffering from tobacco-alcohol toxic neuropathy (TATN).

Methods: Twelve eyes of six patients with TATN were examined with SKP. Area of central scotoma was measured in square degrees (deg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2018.1459666DOI Listing
December 2018
8 Reads

Case Report: Linezolid Optic Neuropathy and Proposed Evidenced-based Screening Recommendation.

Optom Vis Sci 2018 May;95(5):468-474

Salem Veterans Affairs Medical Center, Salem, Virginia.

Significance: This case illustrates a novel screening protocol for linezolid-induced toxic optic neuropathy.

Purpose: To present a case report and analysis of linezolid-induced optic neuropathies in adult patients to develop screening recommendations.

Case Report: A case report of optic neuropathy from extended use of linezolid illustrates its potential effects on vision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/OPX.0000000000001216DOI Listing
May 2018
2 Reads

Abnormal Myocardial Dietary Fatty Acid Metabolism and Diabetic Cardiomyopathy.

Can J Cardiol 2018 05 16;34(5):605-614. Epub 2018 Jan 16.

Division of Endocrinology, Department of Medicine, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Québec, Canada. Electronic address:

Patients with diabetes are at very high risk of hospitalization and death from heart failure. Increased prevalence of coronary heart disease, hypertension, autonomic neuropathy, and kidney failure all play a role in this increased risk. However, cardiac metabolic abnormalities are now recognized to play a role in this increased risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2017.12.029DOI Listing
May 2018
2 Reads