233,585 results match your criteria Toxic Megacolon Imaging


β-Elemene Inhibits Human Sperm Function by Affecting Sperm Vitality and Intracellular Calcium.

Cell Physiol Biochem 2018 Dec 6;51(5):2019-2029. Epub 2018 Dec 6.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou,

Background/aims: β-Elemene is a bioactive sesquiterpene compound that exhibits a potent anti-tumor effect and is used in various clinical applications. However, little is known about its effect on the male reproductive system. The objective of this study was to investigate the in vitro actions of β-elemene on human sperm function and elucidate the underlying mechanism. Read More

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December 2018
2 Reads

A perspective on biogenic synthesis of platinum nanoparticles and their biomedical applications.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 19;211:94-99. Epub 2018 Nov 19.

Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Science Campus, Alagappa University, Karaikudi 630003, India. Electronic address:

In recent era, the interest on inorganic nanoparticles is augmenting due to their engrossing and uncanny properties. Among them, platinum nanoparticles (PtNPs) are highly remarkable owing to their intrinsic physicochemical and biological properties making them an effective candidate towards catalytic and biomedical applications. Nevertheless, conventional physical and chemical methodologies of PtNPs synthesis are among the most prevalent protocols to synthesize PtNPs of desired shape and size. Read More

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November 2018

The involvement of iron responsive element (-) divalent metal transporter 1-mediated the spinal iron overload via CXCL10/CXCR3 pathway in neuropathic pain in rats.

Neurosci Lett 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology, Tianjin First Central Hospital, Tianjin 300192, China. Electronic address:

Background: Iron is pivotal for life, but it is toxic if in excess. Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases. Chemokine-induced neuroinflammation involves the development of pathological pain. Read More

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December 2018

The accumulation of metals, PAHs and alkyl PAHs in the roots of Echinacea purpurea.

PLoS One 2018 6;13(12):e0208325. Epub 2018 Dec 6.

Department of Biology, University of Ottawa, Ottawa, ON, Canada.

We examined the accumulation of polycyclic aromatic hydrocarbons (PAHs), alkyl PAHs, and toxic metals in soils by the roots of Echinacea purpurea (L.) Moench, in a 20-week greenhouse study and a 2-year field study. In the greenhouse study, inoculation by arbuscular mycorrhizal fungus (AMF), Rhizoglomus intraradices (N. Read More

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December 2018
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Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death.

PLoS One 2018 6;13(12):e0208201. Epub 2018 Dec 6.

Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, India.

Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. Read More

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December 2018
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2'-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006930. Epub 2018 Dec 6.

Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil.

Background: To overcome the current problems in leishmaniasis chemotherapy, natural products have become an interesting alternative over the past few decades. Flavonoids have been studied as promising family of compounds for leishmaniasis treatment. 2'-Hydroxyflavanone (2HF) is a flavanone, a class of flavonoid that has shown promising results in cancer studies. Read More

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December 2018

Arsenic concentrations, speciation, and localization in 141 cultivated market mushrooms: implications for arsenic exposure to humans.

Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.

Mushrooms accumulate arsenic (As), yet As concentrations, speciation, and localization in cultivated mushrooms across a large geographic distribution are unknown. We characterized 141 samples of 9 species from markets in 9 capital cities in China, with samples of Lentinula edodes, Pleurotus ostreatus, and Agaricus bisporus being analyzed for As speciation and localization. Total As concentrations ranged 0. Read More

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December 2018

Efficient production of antifungal proteins in plants using a new transient expression vector derived from tobacco mosaic virus.

Plant Biotechnol J 2018 Nov 22. Epub 2018 Nov 22.

Centre for Research in Agricultural Genomics (CRAG, CSIC-IRTA-UAB-UB), Cerdanyola del Vallès, Spain.

Fungi that infect plants, animals or humans pose a serious threat to human health and food security. Antifungal proteins (AFPs) secreted by filamentous fungi are promising biomolecules that could be used to develop new antifungal therapies in medicine and agriculture. They are small highly stable proteins with specific potent activity against fungal pathogens. Read More

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November 2018
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Association of Chemoradiotherapy With Outcomes Among Patients With Stage I to II vs Stage III Small Cell Lung Cancer: Secondary Analysis of a Randomized Clinical Trial.

JAMA Oncol 2018 Dec 6:e185335. Epub 2018 Dec 6.

Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.

Importance: There is limited evidence to guide stage I to II small cell lung cancer (SCLC) treatment.

Objective: To examine the characteristics and outcomes among patients with stage I to II SCLC treated with modern chemoradiotherapy.

Design, Setting, And Participants: In this post hoc secondary analysis of the Concurrent Once-Daily vs Twice-Daily Radiotherapy Trial (CONVERT), a multicenter phase 3 trial conducted in patients with limited-stage SCLC from April 7, 2008, to November 29, 2013, patients with TNM stage I to II SCLC were compared with those with stage III disease. Read More

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December 2018
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Phytol ameliorated benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice via inhibition of oxidative stress and apoptosis.

Environ Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biotechnology, Alagappa University (Science Campus), Karaikudi, Tamil Nadu, India.

In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated group and also in animals post-treated with low concentration (50 mg/kg) of phytol. Read More

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December 2018
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The antibiotic action of methylarsenite is an emergent property of microbial communities.

Mol Microbiol 2018 Nov 22. Epub 2018 Nov 22.

Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, 33199, USA.

Arsenic is the most ubiquitous environmental toxin. Here, we demonstrate that bacteria have evolved the ability to use arsenic to gain a competitive advantage over other bacteria at least twice. Microbes generate toxic methylarsenite (MAs(III)) by methylation of arsenite (As(III)) or reduction of methylarsenate (MAs(V)). Read More

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November 2018

A two-tier standard method to test the toxicity of microplastics in marine water using Paracentrotus lividus and Acartia clausi larvae.

Environ Toxicol Chem 2018 Dec 5. Epub 2018 Dec 5.

ECIMAT, Universidade de Vigo, Illa de Toralla, E-36331, Vigo, Galicia.

A two-tier standardized protocol was designed in order to test the toxicity of microplastics to planktonic organisms. The protocol uses sea-urchin (Paracentrotus lividus) and copepod (Acartia clausi) larvae since they are common biological models in marine research, and standard methods for toxicity testing with regulatory applications are available. In Tier I, leachates obtained at a 100:1 liquid to solid ratio are tested, and toxic units (TU) are calculated using a probit dose:response model in order to quantify the toxicity of the plastics. Read More

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December 2018

Knockdown of sal-like 4 expression by small interfering RNA induces apoptosis in breast cancer cells.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Breast cancer is the most prevalent cancers worldwide and causes a significant amount of deaths annually. Spalt-like transcription factor 4 is known as a transcription factor, which has an important role in the proliferation of cancerous cells. Small interfering RNA (siRNA) is a short-chain molecule of 20 to 25 nucleotides that protrude on two sides of the 3', two nucleotides. Read More

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December 2018

Passive sampling of pesticides and polychlorinated biphenyls (PCBs) along the Quequén Grande River watershed (Argentina).

Environ Toxicol Chem 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Ecotoxicología y Contaminación Ambiental, Instituto de Investigaciones Marinas y Costeras (IIMyC), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Deán Funes 3350, Mar del Plata, 7600, Argentina.

Water monitoring is of great importance, especially for waterbodies in agricultural or industrial areas. Grab sampling is a widely used technique for aquatic monitoring but represents only a snapshot of the contaminant levels at a specific point in time. Passive sampling, on the other hand, is an integrative technique which provides an average concentration of contaminants representative for its deployment period. Read More

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December 2018
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Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system.

J Neurochem 2018 Dec 6. Epub 2018 Dec 6.

Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV.

Improper protein folding and trafficking are common pathological events in neurodegenerative diseases that result in the toxic accumulation of misfolded proteins within the lumen of the endoplasmic reticulum (ER). While low-level stimulation of the unfolded protein response (UPR) is protective, sustained UPR activation resulting from prolonged ER stress can promote neurotoxicity. The cell-autonomous mechanisms of the UPR have been extensively characterized. Read More

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December 2018

Bioassay Method for Toxicity Studies of Toxic Bait Formulations to Ceratitis capitata (Diptera: Tephritidae).

Neotrop Entomol 2018 Dec 5. Epub 2018 Dec 5.

Embrapa Uva e Vinho, Bento Gonçalves, Rio Grande do Sul, Brasil.

The development of appropriate methodologies for bioassays is of paramount importance to study the methodological factors that may interfere in the experimental design. Thus, laboratory bioassays have become increasingly important for the determination of data that are realistic and replicable. The objective of the study was to develop a bioassay methodology with the ready-to-use toxic bait Success™ 0. Read More

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December 2018

[Toxic metabolic alterations of the central nervous system].

Authors:
W Reith

Radiologe 2018 Dec;58(12):1053

Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Deutschland.

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December 2018

Novel insights into molecular chaperone regulation of ribonucleotide reductase.

Curr Genet 2018 Dec 5. Epub 2018 Dec 5.

Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC, 28223, USA.

The molecular chaperones Hsp70 and Hsp90 bind and fold a significant proportion of the proteome. They are responsible for the activity and stability of many disease-related proteins including those in cancer. Substantial effort has been devoted to developing a range of chaperone inhibitors for clinical use. Read More

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December 2018

Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation.

Chem Commun (Camb) 2018 Dec 6. Epub 2018 Dec 6.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

Here, we report the first synthesis of quasi-stable trimer models of full-length Aβ40 with a toxic conformation using a 1,3,5-phenyltris-l-alanyl linker at position 34, 36, or 38. The only trimer to exhibit weak neurotoxicity against SH-SY5Y cells was the one which was linked at position 38. This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model. Read More

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December 2018
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Deep cutaneous infection in a patient recovering from toxic epidermal necrolysis.

Med Mycol Case Rep 2019 Mar 26;23:26-28. Epub 2018 Oct 26.

Brooke Army Medical Center, 3551 Roger Brooke Drive, San Antonio, TX, USA.

Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. Read More

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March 2019
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Investigation of tolerability and quality of life for carboplatin-based chemotherapy in an elderly urothelial carcinoma patient undergoing hemodialysis: a case report.

J Pharm Health Care Sci 2018 29;4:29. Epub 2018 Nov 29.

1Department of Pharmacy, Nagoya City University Hospital, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8602 Japan.

Background: To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly patients' quality of life (QOL) is unknown. We report a case of gemcitabine plus CBDCA chemotherapy treatment in an 81-year-old man with metastatic urothelial carcinoma undergoing hemodialysis. Read More

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November 2018

Physicochemical properties of air discharge-generated manganese oxide nanoparticles: Comparison to welding fumes.

Environ Sci Nano 2018 15;2018(5):696-707. Epub 2018 Jan 15.

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA.

Exposures to high doses of manganese (Mn) via inhalation, dermal contact or direct consumption can cause adverse health effects. Welding fumes are a major source of manganese containing nanoparticles in occupational settings. Understanding the physicochemical properties of manganese-containing nanoparticles can be a first step in understanding their toxic potential following exposure. Read More

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January 2018
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The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells.

J Cancer 2018 11;9(23):4536-4546. Epub 2018 Nov 11.

Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL.

: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy treatment. Previously, we showed that stearidonic acid (SDA), an omega-3 fatty acid, enhances the cytotoxicity of doxorubicin (DOX) in human PCa cells. Read More

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November 2018
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Inhibition or Stimulation of Ochratoxin A Synthesis on Inoculated Barley Triggered by Diffuse Coplanar Surface Barrier Discharge Plasma.

Front Microbiol 2018 16;9:2782. Epub 2018 Nov 16.

Leibniz Institute for Agricultural Engineering and Bioeconomy, Quality and Safety of Food and Feed, Potsdam, Germany.

Ochratoxin A (OTA) is one of the most abundant food-contaminating mycotoxins. Besides their high toxicity, mycotoxins are highly stable to physical, chemical or biological detoxification. Therefore, the treatment with cold atmospheric plasma could be one approach to reduce the amount of mycotoxins in different products. Read More

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November 2018

Endogenous toxins and the coupling of gregariousness to conspicuousness in Argidae and Pergidae sawflies.

Sci Rep 2018 Dec 5;8(1):17636. Epub 2018 Dec 5.

SNSB - Zoologische Staatssammlung München, Münchhausenstr. 21, 81247, Munich, Germany.

Phytophagous insects tend to be either cryptic and solitary, or brightly colored and gregarious, as a defense against vertebrate predators. Here, we tested whether potent defensive chemicals produced de novo by larvae of Argidae and Pergidae sawflies have influenced the evolutionary relationship between larval appearance and levels of gregariousness. Phylogeny-based correlation analyses indicated only a weak trend for solitary species to be cryptic, and for gregarious ones to be conspicuous. Read More

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December 2018

Sustainable production of highly conductive multilayer graphene ink for wireless connectivity and IoT applications.

Nat Commun 2018 Dec 5;9(1):5197. Epub 2018 Dec 5.

School of Electrical and Electronic Engineering, University of Manchester, Manchester, M13 9PL, UK.

Printed electronics offer a breakthrough in the penetration of information technology into everyday life. The possibility of printing electronic circuits will further promote the spread of the Internet of Things applications. Inks based on graphene have a chance to dominate this technology, as they potentially can be low cost and applied directly on materials like textile and paper. Read More

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December 2018

All that is silver is not toxic: silver ion and particle kinetics reveals the role of silver ion aging and dosimetry on the toxicity of silver nanoparticles.

Part Fibre Toxicol 2018 Dec 5;15(1):47. Epub 2018 Dec 5.

Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.

Background: When suspended in cell culture medium, nano-objects composed of soluble metals such as silver can dissolve resulting in ion formation, altered particle properties (e.g. mass, morphology, etc. Read More

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December 2018

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells.

BMC Complement Altern Med 2018 Dec 5;18(1):321. Epub 2018 Dec 5.

Pharmacology and toxicology department, King Saud University, Riyadh, Saudi Arabia.

Background: Eugenol is a natural phenolic compound and possesses anticancer and antibacterial activities. Breast cancer is a major global health problem, and most of the chemotherapeutic agents are highly toxic with long-term side effects. Therefore, this study aimed to explore the possibility of using eugenol as an anti-metastatic and anti-proliferative agent against MDA-MB-231 and SK-BR-3 breast cancer cells. Read More

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December 2018

Zebrafish embryos exposed to deltamethrin exhibited abnormalities in spite of induced expression of related genes ( you, you-too, momo and u-boot).

Toxicol Ind Health 2018 Dec 5:748233718807046. Epub 2018 Dec 5.

2 Department of Animal Biology, School of life Sciences, University of Hyderabad, Telangana, India.

Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. Read More

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December 2018

Review for Analytical Methods for the Determination of Sodium Cephalothin.

Crit Rev Anal Chem 2018 Dec 5:1-8. Epub 2018 Dec 5.

a School of Pharmaceutical Sciences , São Paulo State University (UNESP) , Araraquara , São Paulo , Brazil.

Infections are the second leading cause of global morbidity and mortality, therefore it is highly important to study the antimicrobial agents such as cephalosporins. Cephalothin, an antimicrobial agent that belongs to the class of cephalosporins, has bactericidal activity and it is widely used in the Brazilian health system. In literature, some analytical methods are found for the identification and quantification of this drug, which are essential for its quality control, which ensures maintaining the product characteristics, therapeutic efficacy and patient's safety. Read More

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December 2018

Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

School of Medicine and Surgery, University of Milan-Bicocca, Via Cadore 48, 20900 Monza, Italy.

The cholangipathies are a class of liver diseases that specifically affects the biliary tree. These pathologies may have different etiologies (genetic, autoimmune, viral, or toxic) but all of them are characterized by a stark inflammatory infiltrate, increasing overtime, accompanied by an excess of periportal fibrosis. The cellular types that mount the regenerative/reparative hepatic response to the damage belong to different lineages, including cholagiocytes, mesenchymal and inflammatory cells, which dynamically interact with each other, exchanging different signals acting in autocrine and paracrine fashion. Read More

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December 2018
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MAPLE Assembled Acetylcholinesterase⁻Polyethylenimine Hybrid and Multilayered Interfaces for Toxic Gases Detection.

Sensors (Basel) 2018 Dec 4;18(12). Epub 2018 Dec 4.

National Institute for Lasers, Plasma and Radiation Physics, Magurele RO, Bucharest 077125, Romania.

Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic compounds can be obtained, regarding both materials used as active surfaces and fabrication methods. Herein, we report a preliminary study on using a laser-based method (i. Read More

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December 2018

Homologous Recombination: To Fork and Beyond.

Authors:
Félix Prado

Genes (Basel) 2018 Dec 4;9(12). Epub 2018 Dec 4.

Department of Genome Biology, Andalusian Molecular Biology and Regenerative Medicine Center (CABIMER), CSIC-University of Seville-University Pablo de Olavide, 41092 Seville, Spain.

Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair for later. This process of lesion bypass during DNA damage tolerance can lead to the accumulation of single-strand DNA (ssDNA) fragments behind the fork, which have to be filled in before chromosome segregation. Read More

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December 2018
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Green Synthesis of High Temperature Stable Anatase Titanium Dioxide Nanoparticles Using Gum Kondagogu: Characterization and Solar Driven Photocatalytic Degradation of Organic Dye.

Nanomaterials (Basel) 2018 Dec 4;8(12). Epub 2018 Dec 4.

Institute for Nanomaterials, Advanced Technologies and Innovation (CXI), Technical University of Liberec (TUL), Studentská 1402/2, 46117 Liberec 1, Czech Republic.

The present study reports a green and sustainable method for the synthesis of titanium dioxide (TiO₂) nanoparticles (NPs) from titanium oxysulfate solution using Kondagogu gum (), a carbohydrate polymer, as the NPs formation agent. The synthesized TiO₂ NPs were categorized by techniques such as X-Ray Diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy analysis, Raman spectroscopy, scanning electron microscope- Energy-dispersive X-ray spectroscopy (SEM-EDX), Transmission electron microscopy (TEM), High-resolution transmission electron microscopy (HR-TEM), UV-visible spectroscopy, Brunauer-Emmett-Teller (BET) surface area and particle size analysis. Additionally, the photocatalytic actions of TiO₂ NPs were assessed with regard to their ability to degrade an organic dye (methylene blue) from aqueous solution in the presence of solar light. Read More

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December 2018

Polymorphisms in CYP2E1, GSTM1 and GSTT1 and anti-tuberculosis drug-induced hepatotoxicity.

An Acad Bras Cienc 2014 Jun;86(2):855-865

Departamento de Biologia Molecular e Biotecnologia, IB e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Anti-tuberculosis drug-induced hepatitis (ATD- induced hepatitis) has been linked to polymorphisms in genes encoding drug metabolizing enzymes. N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1) and glutathione S-transferase (loci GSTM1 and GSTT1) are involved in the metabolism of isoniazid, the most toxic drug for the treatment of tuberculosis (TB). This study was designed to determine the frequency and to evaluate whether polymorphisms at CYP2E1, GSTM1 and GSTT1 genes are associated with drug response, as well as to identify clinical risk factors for ATD-induced hepatitis. Read More

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Removing Boundaries to Enhance Communication Between People.

Authors:
Shaw Bronner

Med Probl Perform Art 2018 Dec;33(4):292-293

Alvin Ailey and ADAM Center, New York, NY.

Regardless of your view of national or global politics, we are living through an era of toxic partisan rhetoric. From belligerent tweets on Twitter to "fake news" on Facebook and Instagram, where is this taking us? It is so easy to misunderstand a text and even an email. I've been thinking about the artists we work with and what we do in our professional lives. Read More

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December 2018

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer Sheva, Israel. Electronic address:

Acute myeloid leukemia (AML) is one of the deadliest hematological malignancies without effective treatment for most patients. Vitamin D derivatives (VDDs) - active metabolites 1α,25-dihydroxyvitamin D (1,25D2) and 1α,25-dihydroxyvitamin D (1,25D3) and their analogs - are differentiation-inducing agents which have potential for the therapy of AML. However, calcemic toxicity of VDDs limits their clinical use at doses effective against cancer cells in vivo. Read More

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November 2018
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IN VITRO ANALYSIS OF SYNTHETIC PEPTIDES IN BLOCKING THE ENTRY OF DENGUE VIRUS.

Virus Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address:

Dengue fever is the most prevalent arthropod-borne viral disease, and no specific therapeutic or promising antiviral drug is available for its treatment. Peptide inhibitors are less toxic than synthetic compounds and have found proven effective against viral infections. Here, three peptides that mimic part of the E protein of the dengue virus (DENV) were synthesized and evaluated for their inhibitory activity against four serotypes of DENV in African green monkey kidney (Vero) and rhesus macaque (Macaca mulatta) monkey kidney (LLC-MK2) cell lines. Read More

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November 2018

Reusable Enzymatic Fiber Mats for Neurotoxin Remediation in Water.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Highly effective and reusable organophosphorus hydrolase (OPH)-loaded fiber mats have been fabricated that are capable of degrading toxic organophosphates (OPs) over a broad range of relevant concentrations (from 8 ppm to 8,250 ppm). The inherent fragility of enzymes, a major impediment in their incorporation into technologically-relevant materials, was overcome while retaining their high catalytic efficiency, selectivity and sensitivity via a random heteropolymers (RHP) approach. Kinetic analysis guides the design of polycaprolactone matrix morphology from films to fibers, facilitating substrate diffusion in the material. Read More

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December 2018

Wavelength-Tunable Band-Edge Photoluminescence of Nonstoichiometric Ag-In-S Nanoparticles via Ga Doping.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Graduate School of Engineering , Nagoya University , Chikusa-ku, Nagoya 464-8603 , Japan.

The nonstoichiometry of I-III-VI semiconductor nanoparticles, especially the ratio of group I to group III elements, has been utilized to control their physicochemical properties. We report the solution-phase synthesis of nonstoichiometric Ag-In-S and Ag-In-Ga-S nanoparticles and results of the investigation of their photoluminescence (PL) properties in relation to their chemical compositions. While stoichiometric AgInS nanoparticles simply exhibited only a broad PL band originating from defect sites in the particles, a narrow band edge PL peak newly appeared with a decrease in the Ag fraction in the nonstoichiometric Ag-In-S nanoparticles. Read More

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December 2018

Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand-DNA Adducts.

Chemistry 2018 Dec 3. Epub 2018 Dec 3.

Institut Curie, UMR9187-U1196, Bât. 110, Centre universitaire Paris-Sud, 91405, Orsay, FRANCE.

Ligands interacting with abasic (AP) sites in DNA may generate roadblocks in base-excision DNA repair (BER) due to indirect inhibition of DNA repair enzymes (e.g., APE1) and/or formation of toxic byproducts, resulting from ligand-induced strand cleavage or covalent cross-links. Read More

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December 2018

Cannabinoid receptor 2 agonist prevents local and systemic inflammatory bone destruction in rheumatoid arthritis.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedics, The First Affiliated Hospital of Soochow University.

Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis. Here, we observed that CB2 expression was markedly higher in the collagen-induced arthritis (CIA) mice synovium and bone tissues than in the non-inflamed synovium and bone tissues. The CB2 selective agonist (JWH133) but not antagonist (SR144528) suppressed CIA in mice without toxic effects, as demonstrated by the decreased synovial hyperplasia, inflammatory responses, cartilage damage, and periarticular and systemic bone destruction. Read More

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December 2018

Pesticide Exposure Assessment Paradigm for Stingless Bees.

Environ Entomol 2018 Dec 3. Epub 2018 Dec 3.

Federal University of Bahia (UFBA), Salvador, BA, Brazil.

Although the importance of bees as the pollinators responsible for maintaining gene flow for many native and cultivated plants in ecosystems around the world is recognized, much of their biodiversity and behavior remains to be discovered. Stingless bees are considered key pollinators for several plant species in tropical and subtropical ecosystems and they also provide pollination services for economically important agricultural crops. Many countries are using the honey bee (Apis mellifera Linnaeus, 1758, Hymenoptera: Apidae) as a surrogate to evaluate the risk of pesticides to all species of bees. Read More

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December 2018

Pyrazole appended quinoline-BODIPY based arene ruthenium complexes: their anticancer activity and potential applications in cellular imaging.

Dalton Trans 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi - 221005, UP, India.

Synthesis of an entirely new series of arene ruthenium complexes [Ru(η6-C6H6)(L1)Cl]PF6, (1), [Ru(η6-C10H14)(L1)Cl]PF6 (2), [Ru(η6-C6H6)(L2)Cl]PF6 (3) and [Ru(η6-C10H14)(L2)Cl]PF6 (4) involving 5-[2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L1) and 5-[6-methoxy-2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L2) was described. The ligands and complexes were thoroughly characterized by various physicochemical techniques and the structures of L1, 1 and 4 were determined by X-ray single crystal analyses. Photo-/ and electrochemical property, DNA binding, cytotoxicity, cellular uptake and apoptotic studies on 1-4 were performed by various methods, while singlet oxygen-mediated cytotoxicity via photo-irradiation by visible light was supported by 1,3-diphenylisobenzofuran titration studies. Read More

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December 2018

Arsenic Exposure and Incident Hypertension of Adult Residents Living in Rural Areas Along the Yangtze River, Anhui, China.

J Occup Environ Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Epidemiology and Biostatistics, School of Public Health (Dr Zhong, Ms Zhang, Dr Zhang, Mr Jiang, Dr Liang, Dr Huang); Ma'anshan Center for Disease Control and Prevention, Ma'anshan (Dr Qin, Mr Chen); and Experimental Center Platform for Physical and Chemical (Dr Huang), Anhui Medical University, Hefei, Anhui, P.R. China.

Objective: As a widespread toxic metal, arsenic had potential effect for hypertensive. We evaluated the association between urinary arsenic and the incidence of hypertension in adult residents along the Yangtze River of China.

Methods: We conducted the study of 1358 adults 18 to 74 years of age from Chizhou, Maanshan, and Tongling of Anhui province, who participated in the baseline study in 2014 to 2015. Read More

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November 2018

The Flint Water Crisis: A Coordinated Public Health Emergency Response and Recovery Initiative.

J Public Health Manag Pract 2019 Jan/Feb;25 Suppl 1, Lead Poisoning Prevention:S84-S90

Lead Poisoning Prevention and Environmental Health Tracking Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia (Ms Ruckart and Dr Ettinger); Pediatric Public Health Initiative and Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Flint, Michigan (Dr Hanna-Attisha); Department of Pediatrics and Human Development/Division of Public Health, Michigan State University, East Lansing, Michigan (Dr Jones); Office of Science, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, Georgia (Ms Davis); and National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, Georgia (Dr Breysse).

Context: The City of Flint was already distressed because of decades of financial decline when an estimated 140 000 individuals were exposed to lead and other contaminants in drinking water. In April 2014, Flint's drinking water source was changed from Great Lakes' Lake Huron (which was provided by the Detroit Water and Sewerage Department) to the Flint River without necessary corrosion control treatment to prevent lead release from pipes and plumbing. Lead exposure can damage children's brains and nervous systems, lead to slow growth and development, and result in learning, behavior, hearing, and speech problems. Read More

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December 2018

Lead Elimination for the 21st Century.

J Public Health Manag Pract 2019 Jan/Feb;25 Suppl 1, Lead Poisoning Prevention:S3-S4

National Center for Environmental Health/Agency for Toxic Substances and Disease Registry (NCEH/ATSDR), Centers for Disease Control and Prevention, Atlanta, Georgia.

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December 2018

Growth, pubertal development, and skeletal health in boys with Duchenne Muscular Dystrophy.

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Division of Endocrinology and Diabetes, Golisano Children's Hospital, University of Rochester Medical Centre, Rochester, New York, USA.

Purpose Of Review: Glucocorticoid therapy is currently the most widely used treatment for Duchenne muscular dystrophy (DMD), having consistently shown to prolong ambulation by 2 years, reduce the frequency of scoliosis, and improve cardiorespiratory function. Among the most frequent side effects of glucocorticoids are fractures due to osteoporosis, linear growth retardation or arrest, and pubertal delay, the subjects of this review.

Recent Findings: The diagnosis of osteoporosis has shifted in recent years away from a bone mineral density-centric to a fracture-focused approach, with particular emphasis on early vertebral fracture identification (one of the key triggers for osteoporosis intervention). Read More

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November 2018