6,942 results match your criteria Toxic Epidermal Necrolysis


Burns vs. toxic epidermal necrolysis: A medico-legal dilemma.

Med Leg J 2020 Jun 5:25817220926928. Epub 2020 Jun 5.

Department of Forensic Medicine and Toxicology, Government Medical College & Hospital, Chandigarh, India.

Toxic epidermal necrolysis is a rapidly progressive exfoliating dermatosis which simulates second degree burns. The authors describe a fatal case reported as due to burns. Around 95% of the deceased's total body surface area was affected, with epidermolysis over face, chest, abdomen, limbs and associated with mucosal involvement. Read More

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http://dx.doi.org/10.1177/0025817220926928DOI Listing

Differences in treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis at burn centers and non-burn centers.

J Burn Care Res 2020 Jun 4. Epub 2020 Jun 4.

Hennepin County Medical Center.

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome (SJS/TEN) are severe exfoliative skin disorders resulting primarily from allergic drug reactions and sometimes from viral causes. Because of the significant epidermal loss in many of these patients, many of them end up receiving treatment at a burn center for expertise in the care of large wounds. Previous work on the treatment of this disease focused only on the differences in care of the same patients treated at non-burn centers and then transferred to burn centers. Read More

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http://dx.doi.org/10.1093/jbcr/iraa082DOI Listing

Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.

J Dtsch Dermatol Ges 2020 May 29. Epub 2020 May 29.

Department of Dermatology and Venereology, University Medical Center, Rostock, Germany.

Prior to the first international consensus classification published in 1993, the clinical distinction between erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been subject to uncertainty and controversy for more than a century. Based on this classification, the three conditions are defined by the morphology of the individual lesions and their pattern of distribution. Etiopathogenetically, the majority of EM cases is caused by infections (primarily herpes simplex virus and Mycoplasma pneumoniae), whereas SJS/TEN are predominantly triggered by drugs. Read More

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http://dx.doi.org/10.1111/ddg.14118DOI Listing

Usage Pattern of Carbamazepine and Associated Severe Cutaneous Adverse Reactions in Singapore Following Implementation of Genotyping as Standard-of-Care.

Front Pharmacol 2020 7;11:527. Epub 2020 May 7.

Vigilance and Compliance Branch, Health Products Regulation Group, Health Sciences Authority, Singapore, Singapore.

In April 2013, the Ministry of Health and Health Sciences Authority of Singapore jointly issued recommendations for genotyping before starting carbamazepine (CBZ) in new patients of Asian ancestry as standard of care. The Ministry of Health also approved a 75% subsidy for genotyping to all patients on subsidy at public healthcare institutions. To understand the impact of these regulatory decisions, we researched the usage patterns for CBZ and levetiracetam, the trend of Stevens-Johnson syndrome/toxic epidermal necrolysis [Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)] reports associated with antiepileptic drugs and the take-up rates of tests in Singapore. Read More

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http://dx.doi.org/10.3389/fphar.2020.00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221117PMC

Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

Cureus 2020 May 19;12(5):e8198. Epub 2020 May 19.

Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.

The recent outbreak of COVID-19 has put significant strain on the current health system and has exposed dangers previously overlooked. The pathogen known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), is notable for attacking the pulmonary system causing acute respiratory distress, but it can also severely affect other systems in at-risk individuals including cardiovascular compromise, gastrointestinal distress, acute kidney injury, coagulopathies, cutaneous manifestations, and ultimately death from multi-organ failure. Unfortunately, the reliability of negative test results is questionable and the high infectious burden of the virus calls for extended safety precautions, especially in symptomatic patients. Read More

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http://dx.doi.org/10.7759/cureus.8198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243064PMC

CME Part II: Immune checkpoint inhibitor-related dermatologic adverse events.

J Am Acad Dermatol 2020 May 23. Epub 2020 May 23.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Weill Cornell Medicine, New York, NY. Electronic address:

Immune checkpoint inhibitors (CPI) have emerged as a pillar in the management of advanced malignancies. However, nonspecific immune activation may lead to immune-related adverse events (irAEs), wherein the skin and its appendages are the most frequent targets. Cutaneous irAEs (irCAEs) include a diverse group of inflammatory reactions, with maculopapular rash (MPR), pruritus, and lichenoid dermatitis being the most prevalent subtypes. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.03.132DOI Listing

Genetic association of co-trimoxazole-induced severe cutaneous adverse reactions is phenotype-specific: HLA class I genotypes and haplotypes.

Clin Pharmacol Ther 2020 May 26. Epub 2020 May 26.

Department of Molecular and Clinical Pharmacology, The Royal Liverpool, Broadgreen University Hospitals NHS Trust, MRC Centre for Drug Safety Science, Liverpool Health Partners, University of Liverpool, Liverpool, UK.

Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case-control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (HLA) and CYP2C9 in CTX-induced SCARs, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in Thai patients. Thirty cases of CTX-induced SCARs were enrolled and compared with 91 CTX-tolerant controls and 150 general Thai population. Read More

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http://dx.doi.org/10.1002/cpt.1915DOI Listing

A case of drug-induced bullous pemphigoid associated with teriflunomide: A patient with relapsing multiple sclerosis.

Mult Scler Relat Disord 2020 May 15;43:102157. Epub 2020 May 15.

Hacettepe University, Department of Neurology, Hacettepe, 06230, Ankara, Turkey.

Background: There aren't many reported skin changes associated with teriflunomide use in patients with multiple sclerosis (MS) mm Only one life-threatening gross skin change has been reported so far; a patient with toxic epidermal necrolysis. There are also a few case reports about cutaneous adverse effects of teriflunomide, such as eczema, rash and palmar pustular psoriasis.

Methods: We herein report the first case of bullous drug reaction in a patient receiving teriflunomide treatment. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102157DOI Listing

The effects of systemic cyclosporine in acute Stevens-Johnson syndrome/toxic epidermal necrolysis on ocular disease.

Ocul Surf 2020 May 20. Epub 2020 May 20.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:

Purpose: To evaluate the effect of systemic cyclosporine (CsA) on ocular disease in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients.

Methods: In this retrospective, comparative cohort study at a single center, patients with a diagnosis of SJS/TEN and with at least 3 months of follow up were divided into two groups: those who received systemic CsA and those who did not receive systemic CsA. Best-corrected visual acuity (BCVA) and chronic ocular surface complications score (COCS) at final follow-up were compared between the two groups. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.05.003DOI Listing

A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure.

Allergol Int 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.04.007DOI Listing

TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620926800

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, China.

Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. Read More

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http://dx.doi.org/10.1177/1753466620926800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243041PMC

Treatment of Oculoplastic and Ocular Surface Disease in Eyes Implanted with a Type I Boston Keratoprosthesis in Southern China: A Retrospective Study.

Adv Ther 2020 May 20. Epub 2020 May 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.

Introduction: This study aimed to describe the clinical features, surgical management of the eyelid and ocular surface, and outcomes of 16 patients implanted with a Boston type I keratoprosthesis (KPro).

Methods: A retrospective, single-center, consecutive case series of 16 patients with Stevens-Johnson syndrome (1), ocular chemical burns (12), and ocular thermal burns (3) implanted with KPro was studied. All subjects were men aged 27-51 years. Read More

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http://dx.doi.org/10.1007/s12325-020-01381-3DOI Listing

[European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology].

Hautarzt 2020 May 20. Epub 2020 May 20.

Hautklinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.

Background And Objectives: Treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence-based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future. Read More

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http://dx.doi.org/10.1007/s00105-020-04610-6DOI Listing

HLA-B*58: 01 association in allopurinol-induced severe cutaneous adverse reactions: the implication of ethnicity and clinical phenotypes in multiethnic Malaysia.

Pharmacogenet Genomics 2020 May 19. Epub 2020 May 19.

Department of Dermatology, Hospital Kuala Lumpur, Ministry of Health Malaysia.

Introduction: The association between human leukocyte antigen (HLA)-B*58:01 and risk of allopurinol-induced severe cutaneous adverse reactions (AIS) was observed across different populations. We explore the association between HLA-B*58:01 and AIS risk in multiethnic Malaysian population. The HLA-B*58:01 risk for different AIS clinical phenotypes and ethnicity was determined. Read More

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http://dx.doi.org/10.1097/FPC.0000000000000408DOI Listing

Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease.

Ophthalmic Plast Reconstr Surg 2020 May 15. Epub 2020 May 15.

University of Michigan Medical School, Ann Arbor, Michigan.

Purpose: Conjunctival cicatrizing conditions are vision threatening, with poor outcomes despite aggressive systemic therapy. This study tests the utility of serial injections of 5-fluorouracil (5-FU) into the fornices to treat conjunctival scarring in patients with ocular cicatricial pemphigoid or Stevens-Johnson syndrome/toxic epidermal necrolysis.

Methods: Retrospective cohort study. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001717DOI Listing

Clinical and pathogenic aspects of the severe cutaneous adverse reaction epidermal necrolysis (EN).

J Eur Acad Dermatol Venereol 2020 Mar 12. Epub 2020 Mar 12.

Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.

The severe cutaneous adverse reaction epidermal necrolysis (EN) which includes toxic epidermal necrolysis and the milder Stevens-Johnson syndrome is characterized by epidermal loss due to massive keratinocyte apoptosis and/or necroptosis. EN is often caused by a drug mediating a specific TCR-HLA interaction via the (pro)hapten, pharmacological interaction or altered peptide loading mechanism involving a self-peptide presented by keratinocytes. (Memory) CD8 + T cells are activated and exhibit cytotoxicity against keratinocytes via the perforin/granzyme B and granulysin pathway and Fas/FasL interaction. Read More

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http://dx.doi.org/10.1111/jdv.16339DOI Listing

Ventilatory support in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.

J Dermatolog Treat 2020 May 28:1-6. Epub 2020 May 28.

Sydney Medical School, University of Sydney, Sydney, Australia.

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are blistering cutaneous disorders that often manifest with epidermal and mucosal necrosis. In extreme cases, the upper or bronchial airways are threatened, necessitating intubation and mechanical ventilation. This systematic review and meta-analysis examines the prevalence of mechanical ventilation (MV) in patients with SJS or TENS, despite maximal medical therapy, and additionally aims to identify the risk factors associated with this requirement. Read More

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http://dx.doi.org/10.1080/09546634.2020.1770173DOI Listing
May 2020
1.764 Impact Factor

Stevens Johnson Syndrome in a Patient with Giant Cell Arteritis During Short Term Tocilizumab Therapy.

Cureus 2020 Apr 13;12(4):e7662. Epub 2020 Apr 13.

Allergy and Immunology, Rutgers New Jersey Medical School, Newark, USA.

This case report represents a rare life-threatening hypersensitivity reaction of tocilizumab drug when it is used to treat giant cell arteritis. An elderly female with history of bilateral giant cell arteritis with anterior ischemic optic neuropathy of the right eye was started on tocilizumab after developing glucocorticoid-related complications. She received one month of the tocilizumab therapy along with the prednisone taper. Read More

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http://dx.doi.org/10.7759/cureus.7662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219013PMC

Toxic epidermal necrolysis syndrome induced by tigecycline: a case report.

J Int Med Res 2020 May;48(5):300060520922416

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.

A 56-year-old man diagnosed with non-Hodgkin's lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Read More

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http://dx.doi.org/10.1177/0300060520922416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212PMC

Readmission Risk Factors and Complications in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Cureus 2020 Apr 11;12(4):e7631. Epub 2020 Apr 11.

Internal Medicine, University of Louisville, Louisville, USA.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous hypersensitivity reactions that cause necrosis of the epidermis, often at multiple sites. This process is frequently caused by medications and is associated with significant complications and mortality during hospitalization. However, increasing attention has been drawn to the less studied area of post-hospitalization complications leading to multiple readmissions. Read More

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http://dx.doi.org/10.7759/cureus.7631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213658PMC

Clindamycin induced toxic epidermal necrolysis versus Staphylococcal scalded skin syndrome: a case report.

Oxf Med Case Reports 2020 Mar 6;2020(3):omaa020. Epub 2020 May 6.

National University of Ireland, Galway, Ireland.

Toxic epidermal necrolysis and Staphylococcal scalded skin syndrome (SSSS) are potentially life-threatening dermatological emergencies that present in a similar clinical fashion. Toxic epidermal necrolysis is typically triggered by anticonvulsant and other neurological medications and reports clindamycin inducing the disease is exceedingly rare. SSSS seldomly occurs in adult patients. Read More

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http://dx.doi.org/10.1093/omcr/omaa020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202050PMC

A young male with epitheliolysis in the small bowel and colon.

Scand J Gastroenterol 2020 May 12:1-3. Epub 2020 May 12.

Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Toxic epidermal necrolysis (TEN) is characterized by epidermal necrosis of various degree, and can affect the entire body surface. Affection of small bowel and colon is a rare manifestation of TEN. We present a case with an unusual appearance of epitheliolysis of the small bowel and colon due to a toxic reaction. Read More

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http://dx.doi.org/10.1080/00365521.2020.1760344DOI Listing

Toxic epidermal necrolysis with severe hepatic involvement.

J Dtsch Dermatol Ges 2020 May 11. Epub 2020 May 11.

Dermatology Department, Hospital Universitario y Politécnico la Fe, Valencia, Spain.

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http://dx.doi.org/10.1111/ddg.14110DOI Listing

Bullous pemphigoid secondary to pembrolizumab mimicking toxic epidermal necrolysis.

JAAD Case Rep 2020 May 29;6(5):400-402. Epub 2020 Apr 29.

Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2020.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200194PMC

Early surgical correction of microstomia following Stevens-Johnson syndrome.

Arch Craniofac Surg 2020 Apr 20;21(2):119-122. Epub 2020 Apr 20.

Department of Plastic and Reconstructive Surgery, Inha University Hospital, Incheon, Korea.

Stevens-Johnson syndrome (SJS) is a rare disease in which extensive toxic epidermolysis occurs after medication. Skin and mucous membranes are involved in about 90% of SJS cases, and webbing of mouth corners (microstomia) may occur when they are affected. Few reports have been issued on microstomia in SJS, and no consensus has been reached regarding treatment methods, timings, or results. Read More

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http://dx.doi.org/10.7181/acfs.2019.00759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206467PMC

Erythema Multiforme Versus Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Subtle Difference in Presentation, Major Difference in Management.

Mil Med 2020 May 6. Epub 2020 May 6.

Department of Dermatology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda MD 20889.

Erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis are immune-mediated epidermal conditions with variable clinical presentations. Although their clinical presentations often overlap, they have distinct etiologies and potential outcomes, which necessitate specific management strategies. This case is presented to highlight the subtle differences and review management given that Stevens-Johnson syndrome/toxic epidermal necrolysis can rapidly become life-threatening. Read More

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http://dx.doi.org/10.1093/milmed/usaa029DOI Listing

Comparison of Signal Detection Algorithms Based on Frequency Statistical Model for Drug-Drug Interaction Using Spontaneous Reporting Systems.

Pharm Res 2020 Apr 30;37(5):86. Epub 2020 Apr 30.

Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1196, Japan.

Purpose: Adverse events (AEs) caused by polypharmacy have recently become a clinical problem, and it is important to monitor the safety profile of drug-drug interactions (DDIs). Mining signals using the spontaneous reporting systems is a very effective method for single drug-induced AE monitoring as well as early detection of DDIs. The objective of this study was to compare signal detection algorithms for DDIs based on frequency statistical models. Read More

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http://dx.doi.org/10.1007/s11095-020-02801-3DOI Listing

Stevens-Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn's Disease.

Case Rep Gastrointest Med 2020 15;2020:3875024. Epub 2020 Apr 15.

Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.

Stevens-Johnson syndrome (SJS) is a severe mucocutaneous adverse drug reaction with a relatively high mortality rate. SJS is described during herpes simplex virus type 1 (HSV1) infection and, rarely, even during adalimumab therapy. We report the case of a patient with Crohn's disease who developed SJS during an HSV1 infection and a contemporaneous anti-TNF therapy with adalimumab. Read More

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http://dx.doi.org/10.1155/2020/3875024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180430PMC

The Use of TNFα Inhibitors in Treating Pediatric Skin Disorders.

Paediatr Drugs 2020 Jun;22(3):311-319

Department of Dermatology, UTHealth McGovern Medical School at Houston, Houston, TX, USA.

Tumor necrosis factor alpha (TNF) inhibitors have had a significant impact in medicine since the approval of the first drug of its class by the US FDA in 1998. New clinical data and indications have emerged for TNF inhibitors in recent years. Currently, four TNF inhibitors have been approved by the US FDA for dermatology, two of which include US FDA-approved pediatric use. Read More

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http://dx.doi.org/10.1007/s40272-020-00394-3DOI Listing

Use of Etanercept in a Series of Pediatric Patients With Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis Spectrum Disease.

JAMA Dermatol 2020 Apr 29. Epub 2020 Apr 29.

Department of Dermatology, NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamadermatol.2019.3731DOI Listing

Cancer immunotherapy and toxic epidermal necrolysis.

BMJ Support Palliat Care 2020 Apr 27. Epub 2020 Apr 27.

The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Medical Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.

Objectives: Immunotherapy has come to play an increasingly important role in cancer treatment. Accordingly, immune-related adverse events (irAEs) have drawn considerable attention. In this case, a young female patient developed immune-related toxic epidermal necrolysis (TEN). Read More

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http://dx.doi.org/10.1136/bmjspcare-2019-002135DOI Listing

Toxic Epidermal Necrolysis A Diagnostic Dilemma in Puerperium: A Case Report.

JNMA J Nepal Med Assoc 2019 Sep-Oct;57(219):382-384

Department of Obstetrics and Gynecology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Toxic epidermal necrolysis is a potentially life threatening dermatologic disorder characterized by widespread erythema, necrosis and bullas, detachment of epidermis and mucous membrane resulting in exfoliation, possible sepsis and even death. This is the first case report in Nepal of toxic epidermal necrolysis in puerperium. We present a case of a 28-years-old, P1L1 on fourth postoperative day following emergency lower segment caesarean section for cephalopelvic disproportion in latent phase of labour with uneventful antenatal period. Read More

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Case of toxic epidermal necrolysis successfully treated with repeated i.v. immunoglobulin.

J Dermatol 2020 Apr 24. Epub 2020 Apr 24.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1111/1346-8138.15356DOI Listing

Stevens-Johnson Syndrome: A Perplexing Diagnosis.

Cureus 2020 Mar 23;12(3):e7374. Epub 2020 Mar 23.

Family and Community Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Stevens-Johnson syndrome/toxic epidermal necrolysis is a spectrum of mucocutaneous reactions that can occur due to drug reactions, infections with Mycoplasma pneumonia, human immunodeficiency virus (HIV), cancer, and genetics. Stevens-Johnson syndrome involves less than 10% of the body surface, while toxic epidermal necrolysis involves greater than 30%. The most common site of the lesions is mucocutaneous surfaces such as the eyes and oral cavity. Read More

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http://dx.doi.org/10.7759/cureus.7374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176330PMC

Alteplase treatment for massive lung atelectasis in a child with severe bronchiolitis obliterans complicating Stevens-Johnson syndrome.

Pediatr Pulmonol 2020 Apr 23. Epub 2020 Apr 23.

Pediatric Unit, Department of Mother and Child Health, G. Salesi Children's Hospital, Ancona, Italy.

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http://dx.doi.org/10.1002/ppul.24793DOI Listing

Levetiracetam-induced pediatric toxic epidermal necrolysis successfully treated with etanercept.

Pediatr Dermatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Dermatology, Hospital Clínico Universitario, University of Valencia, Valencia, Spain.

Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults, but few cases have been reported in children. To date, only four pediatric cases of TEN treated with infliximab and one with etanercept have been published. We present the case of an 8-year-old boy diagnosed with TEN induced by levetiracetam, successfully treated with etanercept, systemic corticosteroids, and intravenous immunoglobulin. Read More

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http://dx.doi.org/10.1111/pde.14179DOI Listing

Nikolsky's sign: A pathognomic boon.

J Family Med Prim Care 2020 Feb 28;9(2):526-530. Epub 2020 Feb 28.

Department of Dental Surgery, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India.

Nikolsky's sign has been a very useful diagnostic tool in cases of skin disorders like pemphigus, toxic epidermal necrolysis, etc., The sign is demonstrated when lateral pressure is applied on the border of an intact blister, which results in the dislodgment of the normal epidermis and extension of the blister. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_889_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114071PMC
February 2020

Therapeutic Effects of Mesenchymal Stem Cells on a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Model.

J Korean Med Sci 2020 Apr 20;35(15):e130. Epub 2020 Apr 20.

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are the most severe cutaneous drug hypersensitivity reactions, which are unpredictable adverse drug reactions. SJS/TEN is associated with significant mortality and morbidity; however, effective treatment is difficult. Mesenchymal stem cells (MSCs) are well-known for their anti-inflammatory and tissue regeneration properties. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167404PMC

Long-term sequelae from Stevens-Johnson syndrome / toxic epidermal necrolysis in a large retrospective cohort.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Departments of Dermatology and Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.020DOI Listing

Characterizing the adverse dermatologic effects of hydroxychloroquine: A systematic review.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Department of Dermatology, University of California, San Diego, La Jolla, California. Electronic address:

Background: Hydroxychloroquine is associated with myriad adverse dermatologic effects, most of which are poorly characterized by the literature, with unknown frequencies and risk factors.

Objective: To conduct a systematic review of the adverse dermatologic effects and predisposing factors of hydroxychloroquine toxicity.

Results: The review included 94 articles comprising 689 dermatologic adverse effects. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.024DOI Listing
April 2020
4.449 Impact Factor

Nivolumab-induced toxic epidermal necrolysis with retiform purpura.

Br J Dermatol 2020 Apr 13. Epub 2020 Apr 13.

Department of Dermatology, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1111/bjd.19031DOI Listing

Rash and Mucositis Associated With Mycoplasma pneumoniae and Chlamydophila pneumoniae: A Recurrence of MIRM?

J Pediatric Infect Dis Soc 2020 Apr 10. Epub 2020 Apr 10.

Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois, USA.

Introduction: A new concept has come to light recently, that is, Mycoplasma-induced rash and mucositis (MIRM). Here, we report the first case of recurrent rash, mucositis, and conjunctivitis involving Mycoplasma pneumoniae and C. pneumoniae that fits under the criteria of what is currently defined as MIRM. Read More

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http://dx.doi.org/10.1093/jpids/piaa028DOI Listing

Association of HLA genotypes with phenytoin induced severe cutaneous adverse drug reactions in Thai children.

Epilepsy Res 2020 May 13;162:106321. Epub 2020 Mar 13.

Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, 11000, Thailand. Electronic address:

Purpose: Phenytoin (PHT) is a common causative drug for severe cutaneous adverse drug reactions (SCARs) in children. SCARs, including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are associated with a variation in HLA genotypes. Blood screening for specific HLA allele before PHT prescription would help in the reduction of the incidence of PHT induced SCARs. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106321DOI Listing

Application of a simple point-of-care test to reduce UK healthcare costs and adverse events in outpatient acute respiratory infections.

J Med Econ 2020 Apr 7:1-10. Epub 2020 Apr 7.

FIND (Foundation for Innovative New Diagnostic), Geneva, Switzerland.

Acute respiratory infection (ARI) accounts for over two-thirds of total antibiotic prescriptions although most are caused by viruses that do not benefit from antibiotics. Most antibiotics are prescribed in the outpatients setting. Antibiotic overuse leads to antibiotic-related adverse events (AEs), inclusive of secondary infections, resistance, and increased costs. Read More

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http://dx.doi.org/10.1080/13696998.2020.1736872DOI Listing

Slowly developing toxic epidermal necrolysis-like reaction associated with pemetrexed and carboplatin.

Authors:
Gerhard Eichhoff

Ecancermedicalscience 2020 13;14:1010. Epub 2020 Feb 13.

Capital and Coast District Health Board, Dermatology Service, Wellington Hospital, Wellington, New Zealand.

Most cutaneous adverse drug reactions reported in association with chemotherapy, such as a limited maculopapular rash, are considered mild and do not affect the continuation of the treatment. Toxic epidermal necrolysis (TEN), however, is a life-threatening reaction that needs treatment discontinuation. The present case shows the slow progression from a pemetrexed and carboplatin-associated maculopapular rash to a TEN-like reaction. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105330PMC
February 2020

Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine.

Dermatol Ther 2020 Apr 6:e13380. Epub 2020 Apr 6.

Rutgers New Jersey Medical School, Newark, New Jersey, USA.

A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Given the anticipated surge in the use of hydroxychloroquine due to its reported benefits in those with coronavirus disease 2019, specific recognition of this entity is pivotal. Read More

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http://dx.doi.org/10.1111/dth.13380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235477PMC

[Advances in understanding of the pathophysiology of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis)].

Ann Dermatol Venereol 2020 Jun - Jul;147(6-7):475-481. Epub 2020 Apr 3.

Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; FIMARAD, centre de référence des dermatoses bulleuses toxiques et toxidermies graves, Créteil, France; UPEC, université Paris Est, Créteil, Créteil, France; Université Paris Est, Créteil, EpidermE, Créteil, France.

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http://dx.doi.org/10.1016/j.annder.2020.02.010DOI Listing

Toxic epidermal necrolysis accompanied by several immune-related adverse events developed after discontinuation of nivolumab.

Eur J Cancer 2020 May 2;131:1-4. Epub 2020 Apr 2.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.ejca.2020.02.044DOI Listing

Allogeneic Limbal Epithelial Transplantation Modified With Solid Platelet-Rich Plasma for Bilateral Limbal Stem Cell Deficiency.

Cornea 2020 Mar 27. Epub 2020 Mar 27.

Cornea Department, Hospital General de México "Dr. Eduardo Liceaga," Mexico City, Mexico.

Purpose: To present successful management of bilateral limbal stem cell deficiency (LSCD) by using an allogeneic limbal epithelial stem cell transplantation together with solid activated platelet-rich plasma (PRP).

Methods: A 59-year-old man with a history of bilateral LSCD due to penicillin-induced Stevens-Johnson Syndrome suffered from a lime corneal burn in his right eye, leading to a total LSCD with severely reduced visual acuity. After stabilizing the ocular surface, we performed an allogeneic limbal epithelial transplantation from a cadaveric donor using an autologous clot of PRP to cover the limbal grafts to nourish the ocular surface microenvironment. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002321DOI Listing