6,572 results match your criteria Toxic Epidermal Necrolysis


HLA associated antiepileptic drug-induced cutaneous adverse reactions.

HLA 2019 Mar 20. Epub 2019 Mar 20.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

Adverse drug reactions (ADRs) are a common cause of hospital admissions (up to 19%), with the majority of cases due to off-target predictable drug effects (type A reactions). However, idiosyncratic drug-induced immune activated (type B) reactions contribute to a range of hypersensitivity reactions, with T-cell mediated type IV hypersensitivity reactions mainly manifesting as cutaneous ADRs (cADRs). Aromatic antiepileptic drugs (AEDs), used in the treatment of epilepsy as well as bipolar disorder or neuropathic pain, have been implicated as culprit drugs in a spectrum of pathologies ranging from mild maculopapular exanthema (MPE) to severe and life-threatening conditions including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

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http://dx.doi.org/10.1111/tan.13530DOI Listing

Incidence of bloodstream infections and predictive value of qualitative and quantitative skin cultures of patients with overlap syndrome or toxic epidermal necrolysis: a retrospective observational cohort study of 98 cases.

J Am Acad Dermatol 2019 Mar 16. Epub 2019 Mar 16.

Department of Dermatology, AP-HP Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France, Université Paris Est UPEC, Créteil France; National Reference Center for Toxic Bullous Dermatosis, AP-HP Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France, Université Paris Est UPEC, Créteil France; EA7379, UPEC, Créteil, France. Electronic address:

Background: Epidermal necrolysis (EN) involving ≥10% body surface area (BSA) is often complicated by bacterial infections.

Objective: To describe the epidemiology of bloodstream infections (BSIs) in EN involving a BSA≥10% and the diagnostic performances of skin cultures for predicting the pathogen(s) isolated from BSIs.

Methods: This retrospective single-center observational study was conducted between 2009 and 2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.030DOI Listing

Sutureless amniotic membrane transplantation with cyanoacrylate glue for acute Stevens-Johnson syndrome/toxic epidermal necrolysis.

Ocul Surf 2019 Mar 11. Epub 2019 Mar 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. Electronic address:

Amniotic membrane (AM) transplantation, when performed in the acute phase in Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) for patients with ocular complications, is known to reduce the morbidity of ocular complications in the chronic phase. In conditions such as SJS/TEN, AM needs to be secured to the ocular surface as well as the eyelids. Previously, techniques of securing a large sheet of AM with fibrin glue to the ocular surface and with sutures and bolsters to the eyelids have been described in the acute phase of SJS/TEN. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.03.001DOI Listing
March 2019
1 Read

Ciprofloxacin-induced Stevens-Johnson Syndrome with Grapefruit Juice Consumption: A Case Report.

Cureus 2019 Jan 4;11(1):e3827. Epub 2019 Jan 4.

Dermatology, University of Arizona College of Medicine, Tucson, USA.

We describe the case of a 49-year-old, otherwise healthy, Hispanic male who underwent an uncomplicated vasectomy and was treated prophylactically with a one-week course of ciprofloxacin. Two days after completing the antibiotic course, he developed a pruritic, blistering rash that covered 90% of his body surface area. Punch biopsy of the skin lesions confirmed the diagnosis of Stevens-Johnson syndrome (SJS). Read More

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http://dx.doi.org/10.7759/cureus.3827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402866PMC
January 2019

A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine.

Methods Mol Biol 2019 ;1939:181-198

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

In the era of big data and informatics, computational integration of data across the hierarchical structures of human biology enables discovery of new druggable targets of disease and new mode of action of a drug. We present herein a computational framework and guide of integrating drug targets, gene expression data, transcription factors, and prior knowledge of protein interactions to computationally construct the signaling network (mode of action) of a drug. In a similar manner, a disease network is constructed using its disease targets. Read More

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http://link.springer.com/10.1007/978-1-4939-9089-4_10
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http://dx.doi.org/10.1007/978-1-4939-9089-4_10DOI Listing
January 2019
2 Reads

Chemotherapy-induced skin toxicity and capillary leak syndrome.

Int J Dermatol 2019 Mar 7. Epub 2019 Mar 7.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.

Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Read More

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http://dx.doi.org/10.1111/ijd.14392DOI Listing
March 2019
1 Read

Development and Validation of a Risk Prediction Model for In-Hospital Mortality Among Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis-ABCD-10.

JAMA Dermatol 2019 Mar 6. Epub 2019 Mar 6.

Department of Dermatology, University of Pennsylvania, Philadelphia.

Importance: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of severe mucocutaneous drug reaction associated with significant morbidity and mortality. A previously developed SJS/TEN-specific severity-of-illness model (Score of Toxic Epidermal Necrolysis [SCORTEN]) has been reported to overestimate and underestimate SJS/TEN-related in-hospital mortality in various populations.

Objective: To derive a risk prediction model for in-hospital mortality among patients with SJS/TEN and to compare prognostic accuracy with the SCORTEN model in a multi-institutional cohort of patients in the United States. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5605DOI Listing
March 2019
5 Reads

Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo.

Dermatol Res Pract 2019 30;2019:4917024. Epub 2019 Jan 30.

Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, Togo.

Aim: The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae.

Patients And Method: Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone.

Results: Between January 1995 and December 2017, 177 cases of SJS/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS/TEN overlap) were admitted into two university hospitals of Lomé (Togo). Read More

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http://dx.doi.org/10.1155/2019/4917024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374872PMC
January 2019
1 Read

Pediatric toxic epidermal necrolysis treated successfully with infliximab.

Pediatr Dermatol 2019 Mar 4. Epub 2019 Mar 4.

Departments of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Read More

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http://dx.doi.org/10.1111/pde.13778DOI Listing
March 2019
2 Reads

Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

Acta Biomed 2019 Jan 29;90(3-S):52-60. Epub 2019 Jan 29.

Department of Pediatrics, Senigallia Hospital, Senigallia, Italy.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN are considered a spectrum of life-threatening adverse drug reactions. They have the same clinical manifestations and the only difference is in the extent of epidermal detachment. Read More

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http://dx.doi.org/10.23750/abm.v90i3-S.8165DOI Listing
January 2019
1 Read

British Association of Dermatologists guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in children and young people 2018.

Br J Dermatol 2019 Mar 4. Epub 2019 Mar 4.

Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, U.K.

The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in children (0-12) and young people (13-17) during the acute phase of the disease. The document aims to: offer an appraisal of all relevant literature up to July 2018, focusing on any key developments. address important, practical clinical questions relating to the primary guideline objective. Read More

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http://dx.doi.org/10.1111/bjd.17841DOI Listing

Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population.

Seizure 2019 Feb 20;66:99-103. Epub 2019 Feb 20.

All India Institute of Medical Sciences, Neurology, Neurosciences Centre, Room no-705, 7th floor, 110029, New Delhi, India. Electronic address:

Purpose: Aromatic antiepileptic drugs (AEDs) are frequently implicated in cutaneous adverse drug reactions (cADRs), a few of which are associated with certain human leukocyte antigen (HLA) alleles in some populations. We aimed to find HLA-associations with AED-related cADRs among North Indians.

Methods: North Indian subjects with cADR due to an AED, and those who were AED-tolerant were recruited as cases and controls, respectively. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.011DOI Listing
February 2019
7 Reads

Stevens-Johnson syndrome and toxic epidermal necrolysis: retrospective review of 10-year experience.

Int J Dermatol 2019 Mar 1. Epub 2019 Mar 1.

Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous disorders. To date, relatively few studies have looked at institutional approaches to treatment of SJS/TEN, particularly with a focus on wound care.

Methods: A retrospective review was conducted on patients admitted to the Hennepin County Medical Center from 2007 to 2017 with a final diagnosis of SJS or TEN. Read More

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http://dx.doi.org/10.1111/ijd.14409DOI Listing
March 2019
1 Read

Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.

Int J Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacy Practice, JSS College of Pharmacy, Jagadguru Shri Shivarathreeshwara University, Mysuru, Karnataka, India.

Valproic acid (VPA) is a commonly used antiepileptic drug (AED). Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are the rare but fatal cutaneous adverse drug reactions for VPA. We aimed to identify and critically evaluate all the literature of SJS in association with VPA and to describe the clinical features of the condition. Read More

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http://dx.doi.org/10.1111/ijd.14411DOI Listing
February 2019
3 Reads

Skin Complications of Orthopedic Procedures and Devices.

Iran J Public Health 2018 Dec;47(12):1937-1944

Kassir Dermatology, Dallas, Texas, USA.

Background: Knowledge of skin complications and contributing factors in orthopedic patients is important for design and development of preventive approaches. Therefore, this study was designed to assess skin complications in orthopedic patients.

Methods: In this case-series study, 126 orthopedic patients referred to Rasoul-e-Akram and Bahman hospitals from 2012 to 2016 with skin complications were analyzed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379618PMC
December 2018
2 Reads

Spectrum of gastrointestinal involvement in Stevens - Johnson syndrome.

World J Gastrointest Endosc 2019 Feb;11(2):115-123

Health Center, National Institute of Technology, Patna 800014, India.

Stevens - Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with involvement of skin and mucosal membranes, and carries significant risk of mortality and morbidity. Mucus membrane lesions usually involve the oral cavity, lips, bulbar conjunctiva and the anogenitalia. The oral/anal mucosa and liver are commonly involved in SJS or TEN. Read More

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http://dx.doi.org/10.4253/wjge.v11.i2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379748PMC
February 2019

Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

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http://dx.doi.org/10.5858/arpa.2018-0239-RADOI Listing
February 2019
1 Read

Late-onset Stevens-Johnson syndrome due to nivolumab use for hepatocellular carcinoma.

J Oncol Pharm Pract 2019 Feb 19:1078155219830166. Epub 2019 Feb 19.

1 Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, CA, USA.

Nivolumab is a fully human immunoglobulin G4 immune checkpoint inhibitor antibody approved for use in the treatment of several malignancies. Severe side effects such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have only extremely rarely been reported with this drug. We present herein a patient who developed SJS after 16 weeks of therapy with nivolumab. Read More

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http://dx.doi.org/10.1177/1078155219830166DOI Listing
February 2019
3 Reads

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019
6 Reads

[Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)].

Bull Soc Pathol Exot 2018 ;111(1):9-11

Service d'anesthésie-réanimation, CHU de Bouaké, BP 1174 Bouaké, Côte d'Ivoire.

Lyell's syndrome or toxic epidermal necrolysis is an acute and severe cutaneous adverse drug reaction with a significant morbidity and mortality. It is a very rare condition but a vital emergency with a poor prognosis. The diagnosis is clinical and confirmed by a cutaneous biopsy showing a necrosis of the epidermis. Read More

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http://dx.doi.org/10.3166/bspe-2018-0009DOI Listing
January 2018

Intravenous immunoglobulin treatment: Where do dermatologists stand?

Authors:
Selma Emre

Dermatol Ther 2019 Feb 13:e12854. Epub 2019 Feb 13.

Department of Dermatology, Yildirim Beyazit University, Medical School, Ankara, Turkey.

Intravenous immunoglobulins (IVIG) are therapeutic products, comprising polyclonal IgGs, which are obtained from human plasma pool of healthy blood donors. Despite the lack of Food and Drug Administration (FDA) approval, the experience of using IVIG in various dermatological diseases increases day by day and exciting results are reported. However, experience with the use of IVIG in dermatological indications are mostly case reports whereas randomized, controlled, double-blind, multicentric studies have not been performed. Read More

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http://dx.doi.org/10.1111/dth.12854DOI Listing
February 2019
5 Reads

Bullous Pemphigoid-like Skin Eruption during Treatment with Rivaroxaban: A Clinical Case Study.

Eur J Case Rep Intern Med 2018 21;5(3):000724. Epub 2018 Mar 21.

Serviço de Anatomia Patológica, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Little has been documented about hypersensitivity reactions caused by treatment with rivaroxaban. This paper reports a bullous pemphigoid-like skin eruption that occurred in a 76-year-old female patient during rivaroxaban treatment. This case highlights the vigilance required by healthcare workers in recognising potential adverse effects of newly marketed drugs and in making medication changes when necessary. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/724
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http://dx.doi.org/10.12890/2018_000724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346955PMC
March 2018
3 Reads

-associated Mucositis: A Recently Described Entity.

Eur J Case Rep Intern Med 2018 28;5(11):000977. Epub 2018 Nov 28.

Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

(MP) is a common cause of respiratory infections and can be associated with extrapulmonary complications. MP mucositis has recently been described as a distinct endemic clinical entity called e-induced rash and mucositis (MIRM). The authors present the case of a 46-year-old man with atypical pneumonia associated with exuberant mucositis, conjunctival hyperaemia and positive serological assays for MP IgM. Read More

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http://dx.doi.org/10.12890/2018_000977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346809PMC
November 2018
1 Read

Ocular Surface Reconstruction Using Circumferentially-trephined Autologous Oral Mucosal Graft Transplantation in Limbal Stem Cell Deficiency.

Korean J Ophthalmol 2019 Feb;33(1):16-25

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To investigate the effects of transplantation of a circumferentially-trephined autologous oral mucosal graft using a vacuum trephine on ocular surface reconstruction in patients with limbal stem cell deficiency.

Methods: Patients with a limbal stem cell deficiency who underwent transplantation of autologous oral mucosal graft performed by a particular surgeon in Seoul National University Hospital were included. The medical records of these five patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.3341/kjo.2018.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372385PMC
February 2019
1 Read

Bronchiolitis Obliterans After Cefuroxime-Induced Stevens-Johnson Syndrome.

Am J Case Rep 2019 Feb 9;20:171-174. Epub 2019 Feb 9.

Department of Inernal Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

BACKGROUND Bronchiolitis obliterans is the term used to describe a clinical syndrome of irreversible airflow obstruction. Among the etiologies linked to this entity is the rarely reported association with Stevens-Johnson syndrome, which has had a poor outcome in most of the previously published cases. The optimum management of bronchiolitis obliterans as a complication of Stevens-Johnson syndrome is not well defined. Read More

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http://dx.doi.org/10.12659/AJCR.913723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380208PMC
February 2019
1 Read

Multi-Step Grading System for Evaluation of Chronic Ocular Sequelae in Patients with Stevens-Johnson Syndrome.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Vision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre, University of Melbourne, Australia.

Purpose: To propose a new scoring system for grading of chronic ocular sequelae in Stevens-Johnson syndrome (SJS).

Design: Reliability and validity analysis PARTICIPANTS: Four hundred eyes of 200 patients with chronic ocular SJS/TEN were included in the study.

Settings: Single centre, tertiary eye care referral centre METHODS: All patients of SJS/TEN with chronic (more than one year) ocular sequelae were recruited for the study. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.028DOI Listing
February 2019
1 Read

Docetaxel-Induced Stevens-Johnson Syndrome in a Patient with Metastatic Prostate Adenocarcinoma.

Case Rep Oncol Med 2019 8;2019:7928752. Epub 2019 Jan 8.

Department of Medicine, Creighton University, Omaha, NE, USA.

Docetaxel is a commonly used chemotherapeutic agent in a variety of cancer treatment regimens. We present a case of apparent docetaxel-induced Stevens-Johnson syndrome (SJS) in a patient recently treated for metastatic prostate cancer. This medication is not classically associated with the development of SJS but in our case, along with a number of other case reports, and a single phase II clinical trial, an association was recognized. Read More

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http://dx.doi.org/10.1155/2019/7928752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341237PMC
January 2019
2 Reads

Epidermal necrolysis: SCORTEN performance in AIDS and non-AIDS patients.

An Bras Dermatol 2019 Jan-Feb;94(1):17-23

Division of Dermatology, Department of Internal Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa (PR), Brazil.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening blistering drug reactions with high incidence of ocular sequela. The term 'Epidermal Necrolysis' has been recently used to better describe the full spectrum of the disease that includes Stevens-Johnson syndrome and toxic epidermal necrolysis at opposite ends, which differ by the extent of body surface area with epidermal detachment. SCORTEN is a mortality prognosis score for 'Epidermal Necrolysis' cases that still needed validation in acquired immunodeficiency syndrome. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20196864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360969PMC
February 2019
2 Reads

Toxic Epidermal Necrolysis Induced by Leflunomide in a Patient With Rheumatoid Arthritis.

J Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Rheumatology and Immunology The Affiliated Hospital of Inner Mongolia Medical University Hohhot, Department of Rheumatology and Immunology The Affiliated Hospital of Inner Mongolia Medical University Hohhot, China.

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http://dx.doi.org/10.1097/RHU.0000000000000997DOI Listing
February 2019
9 Reads

Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Background/aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313263DOI Listing
January 2019
1 Read

Biologic TNF-alpha inhibitors in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: a systemic review.

J Dermatolog Treat 2019 Jan 31:1-8. Epub 2019 Jan 31.

a Department of Dermatology, First Affiliated Hospital , College of Medicine, Zhejiang University , Hangzhou , China.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) is one of severe cutaneous adverse reactions with low morbidity but high mortality. Different systemic immunomodulating treatments are proposed but still remain controversial. Tumor necrosis factor (TNF)-alpha is long thought to be a vital mediator of epithelial cell death in SJS-TEN, indicating a potential target for therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1577548DOI Listing
January 2019
7 Reads

A Review of the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Adv Emerg Nurs J 2019 Jan/Mar;41(1):56-64

Department of Pharmacy Services, University of Kentucky HealthCare, Lexington.

Stevens-Johnson syndrome and toxic epidermal necrolysis represent a spectrum of severe cutaneous adverse reactions that carry the potential for severe, long-term adverse effects, including death. Although medications are most commonly implicated in the development of these diseases, other factors, including infection and genetics, play a role. Management is generally supportive in nature and includes maintenance of the patient's airway, breathing, and circulation. Read More

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http://dx.doi.org/10.1097/TME.0000000000000225DOI Listing
February 2019
2 Reads

Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database.

Clin Drug Investig 2019 Jan 28. Epub 2019 Jan 28.

Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Background And Objective: Adverse cutaneous drug reactions associated with antiepileptic drugs (AEDs) are a serious problem in the clinical setting. New-generation AEDs have been reported to be better tolerated than old-generation forms; however, information about the risks of adverse cutaneous drug reactions to new-generation AEDs is limited.

Objective: The purpose of this study was to clarify the association of AEDs with adverse cutaneous drug reactions using a spontaneous reporting database. Read More

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http://dx.doi.org/10.1007/s40261-019-00754-zDOI Listing
January 2019

Oseltamivir-induced toxic epidermal necrolysis in a patient with Cushing's disease.

Indian J Dermatol Venereol Leprol 2019 Jan 25. Epub 2019 Jan 25.

PIELenRed Consortium, Príncipe de Asturias University Hospital, Alcalá de Henares; Department of Endocrinology and Nutrition, La Paz University Hospital, Autonomous University of Madrid, Madrid, Spain.

We report a case of a patient with Cushing's disease with oseltamivir-induced toxic epidermal necrolysis, who was treated with cyclosporine with favorable evolution. There is only one case reported of Cushing's disease and toxic epidermal necrolysis and very few oseltamivir-induced toxic epidermal necrolysis cases in literature. This report also discusses the role that the preexisting hypercortisolism condition may have played in the development and favorable resolution of the toxic epidermal necrolysis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_53_18DOI Listing
January 2019
1 Read

Interventions for erythema multiforme: a systematic review.

J Eur Acad Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Service de Dermatologie, AP-HP, Hôpital Henri Mondor, Créteil, France.

Treatment of erythema multiforme (EM) is not codified. We performed a systematic review of the effect of any topical or systemic treatment on time to healing and frequency of episodes with acute and chronic forms of EM in adults. Four databases (MEDLINE, CENTRAL, EMBASE and LILACS) and other sources were searched for articles published up to 20 March 2018. Read More

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http://dx.doi.org/10.1111/jdv.15447DOI Listing
January 2019
1 Read

Stevens - Johnson syndrome (SJS) following Murunga leaf (Moringa oleifera) consumption

Ceylon Med J 2018 12;63(4):188-189

Base Hospital, Deniyaya, Sri Lanka.

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http://dx.doi.org/10.4038/cmj.v63i4.8771DOI Listing
December 2018
1 Read

Analysis of Individual Case Safety Reports of Severe Cutaneous Adverse Reactions in Korea.

Yonsei Med J 2019 Feb;60(2):208-215

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Purpose: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea.

Materials And Methods: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting System from 1988 to 2013. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.2.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342723PMC
February 2019
3 Reads

Prosthetic Replacement of the Ocular Surface Ecosystem Treatment for Ocular Surface Disease in Pediatric Patients with Stevens-Johnson Syndrome.

Am J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: To report the outcomes of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment in pediatric patients with chronic ocular surface disease associated with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).

Design: Retrospective, interventional case series METHODS: Patients ages 18 or younger seen in consultation for PROSE treatment at a single center between January 1992 and December 2016 with a history of SJS/TEN were reviewed. Demographics, etiology of SJS/TEN, age at treatment milestones, best corrected visual acuity (BCVA) at treatment milestones and treatment failures were recorded. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.006DOI Listing
January 2019
4 Reads

Severe Cutaneous Adverse Reactions in Korean Pediatric Patients: A Study From the Korea SCAR Registry.

Allergy Asthma Immunol Res 2019 Mar;11(2):241-253

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Although severe cutaneous adverse drug reactions (SCARs) are rare, they are associated with high morbidity and mortality, and thus early diagnosis and treatment are critical for improving prognoses. However, few studies have reported the characteristics of SCARs in children. Thus, we aimed to evaluate the clinical characteristics, current management and prognosis of pediatric SCARs. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340806PMC
March 2019
4 Reads

Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs.

Allergy Asthma Immunol Res 2019 Mar;11(2):212-221

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Purpose: Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean SCAR registry.

Methods: A retrospective survey of NSAID-induced SCARs recorded between 2010 and 2015 at 27 university hospitals in Korea was conducted. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2019.1
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http://dx.doi.org/10.4168/aair.2019.11.2.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340804PMC
March 2019
10 Reads
3.084 Impact Factor

Rapid remission of Stevens-Johnson syndrome by combination therapy using etanercept and intravenous immunoglobulin and a review of the literature.

Dermatol Ther 2019 Jan 18:e12832. Epub 2019 Jan 18.

Department of Dermatology, Peking University First Hospital, Beijing, China.

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are spectrum of rare, acute, and life-threatening delayed-type drug hypersensitivity reactions that are associated with high mortality rates. However, no therapeutic standard has been proposed for SJS/TEN. Here, we report a case of a patient diagnosed with Stevens-Johnson syndrome whose disease progression was halted by a single dose of etanercept and was treated successfully. Read More

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http://doi.wiley.com/10.1111/dth.12832
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http://dx.doi.org/10.1111/dth.12832DOI Listing
January 2019
8 Reads

Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study.

BMC Ophthalmol 2019 Jan 18;19(1):22. Epub 2019 Jan 18.

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Background: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Methods: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. Read More

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http://dx.doi.org/10.1186/s12886-018-1014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339389PMC
January 2019
3 Reads

Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007⁻2018.

Pharmacy (Basel) 2019 Jan 17;7(1). Epub 2019 Jan 17.

Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-531 Krakow, Poland.

Paracetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for patient management. The EudraVigilance (EV) database serves as a system for monitoring adverse events (AE) due to drug intake. Read More

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http://dx.doi.org/10.3390/pharmacy7010012DOI Listing
January 2019
6 Reads

Incidence of pneumocystosis among patients exposed to immunosuppression.

J Am Acad Dermatol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York. Electronic address:

Background: The decision to administer prophylaxis to patients receiving immunosuppression against pneumocystosis remains a dilemma.

Objective: To determine overall and age-specific 5-year pneumocystosis incidence within a population exposed to immunosuppressants.

Methods: Retrospective cohort analysis identifying incident pneumocystosis cases among adults without HIV, AIDS, or cancer exposed to immunosuppressant, corticosteroid therapy, or both. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.052DOI Listing
January 2019
1 Read

Allopurinol-Induced Stevens-Johnson Syndrome.

Am J Med Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York.

Allopurinol is a first line agent in treating gout, but it also carries the risk of severe side effects. Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol. The severity of the severe cutaneous adverse reactions can be categorized based upon the area of skin involvement: (1) erythema multiforme major limited to 1-2 % of the body surface area (BSA); (2) SJS involving <10% of the BSA, (3) SJS and toxic epidermal necrolysis overlap involving 10-30% of the BSA and (4) toxic epidermal necrolysis syndrome involving >30% of the BSA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183044
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http://dx.doi.org/10.1016/j.amjms.2018.11.018DOI Listing
December 2018
8 Reads

Dark skin phototype is associated with more severe ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Br J Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology - Charles Nicolle University Hospital, Rouen, France.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe skin reactions with extensive apoptosis of the epidermis and mucous membranes. Ocular involvement occurs in up to 75% of patients at the acute phase, described as mild, moderate and severe involvement and may result in long-term severe sequelae with dryness, photophobia, cicatrising conjunctivitis complicated with corneal vascularisation and scarring, which may result in severe visual loss. The acute management of SJS/TEN ocular complications has not been codified. Read More

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http://dx.doi.org/10.1111/bjd.17627DOI Listing
January 2019
9 Reads

Stevens Johnson Syndrome and Toxic Epidermal Necrolysis - an Australian analysis of treatment outcomes and mortality.

J Dermatolog Treat 2019 Jan 11:1-19. Epub 2019 Jan 11.

b Department of Dermatology , Royal Adelaide Hospital , Australia.

Background: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases with devastating consequences on morbidity and mortality. There are currently no standardized guidelines for treatment of SJS/TEN in Australia.

Method: Retrospective chart review of all SJS/TEN cases treated at the Royal Adelaide Hospital from 2000 to 2017. Read More

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http://dx.doi.org/10.1080/09546634.2019.1568380DOI Listing
January 2019
6 Reads

Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab.

Ann Otol Rhinol Laryngol 2019 Apr 11;128(4):365-368. Epub 2019 Jan 11.

2 MEEI, Boston, MA, USA.

Objective:: To describe an observed case of spontaneous regression of cholesteatoma in a patient on chronic anti-tumor necrosis factor-alpha (TNF-a) therapy and inspire further research into the role of TNF-a in cholesteatoma.

Methods:: Clinical assessment of disease in a single-patient case report.

Results:: A 49-year-old woman suffered a severe case of Stevens-Johnson syndrome when she was 12 years old, leaving her with bilateral corneal opacification and tympanic membrane perforations with extensive cholesteatoma. Read More

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http://dx.doi.org/10.1177/0003489418823790DOI Listing
April 2019
6 Reads

Use of Cyclosporine for the treatment of Steven Johnson Syndrome/ Toxic Epidermal Necrolysis.

J Am Acad Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Massachusetts General Hospital Department of Dermatology. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.09.063DOI Listing
January 2019
1 Read

Comprehensive assessment of T cell receptor β repertoire in Stevens-Johnson syndrome/toxic epidermal necrolysis patients using high-throughput sequencing.

Mol Immunol 2019 Feb 7;106:170-177. Epub 2019 Jan 7.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Stevens-Johnson syndrome (SJS) /toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse drug reactions characterized by widespread epidermal necrosis. Recent studies have indicated that SJS/TEN is a specific immune reaction regulated by T cells. Certain drug serves as foreign antigens that are presented by major histocompatibility complex (MHC) and recognized by T cell receptors (TCRs), inducing adaptive immune responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183080
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http://dx.doi.org/10.1016/j.molimm.2019.01.002DOI Listing
February 2019
9 Reads