6,520 results match your criteria Toxic Epidermal Necrolysis


Incidence of Pneumocystosis Among Patients Exposed to Immunosuppression.

J Am Acad Dermatol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, NY. Electronic address:

Background: The decision to administer prophylaxis to patients receiving immunosuppression against pneumocystosis remains a dilemma.

Objective: To determine overall and age-specific 5-year pneumocystosis incidence within a population exposed to immunosuppressants.

Methods: Retrospective cohort analysis identifying incident pneumocystosis cases among adults without HIV/AIDS or cancer exposed to immunosuppressant and/or corticosteroid therapy. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.052DOI Listing
January 2019

Allopurinol-Induced Stevens-Johnson Syndrome.

Am J Med Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York.

Allopurinol is a first line agent in treating gout, but it also carries the risk of severe side effects. Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol. The severity of the severe cutaneous adverse reactions can be categorized based upon the area of skin involvement: (1) erythema multiforme major limited to 1-2 % of the body surface area (BSA); (2) SJS involving <10% of the BSA, (3) SJS and toxic epidermal necrolysis overlap involving 10-30% of the BSA and (4) toxic epidermal necrolysis syndrome involving >30% of the BSA. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.018DOI Listing
December 2018

Dark skin phototype is associated with more severe ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Br J Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology - Charles Nicolle University Hospital, Rouen, France.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute severe skin reactions with extensive apoptosis of the epidermis and mucous membranes. Ocular involvement occurs in up to 75% of patients at the acute phase, described as mild, moderate and severe involvement and may result in long-term severe sequelae with dryness, photophobia, cicatrising conjunctivitis complicated with corneal vascularisation and scarring, which may result in severe visual loss. The acute management of SJS/TEN ocular complications has not been codified. Read More

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http://dx.doi.org/10.1111/bjd.17627DOI Listing
January 2019
1 Read

Stevens Johnson Syndrome and Toxic Epidermal Necrolysis - an Australian analysis of treatment outcomes and mortality.

J Dermatolog Treat 2019 Jan 11:1-19. Epub 2019 Jan 11.

b Department of Dermatology , Royal Adelaide Hospital , Australia.

Background: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases with devastating consequences on morbidity and mortality. There are currently no standardized guidelines for treatment of SJS/TEN in Australia.

Method: Retrospective chart review of all SJS/TEN cases treated at the Royal Adelaide Hospital from 2000 to 2017. Read More

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http://dx.doi.org/10.1080/09546634.2019.1568380DOI Listing
January 2019
1 Read

Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab.

Ann Otol Rhinol Laryngol 2019 Jan 11:3489418823790. Epub 2019 Jan 11.

2 MEEI, Boston, MA, USA.

Objective:: To describe an observed case of spontaneous regression of cholesteatoma in a patient on chronic anti-tumor necrosis factor-alpha (TNF-a) therapy and inspire further research into the role of TNF-a in cholesteatoma.

Methods:: Clinical assessment of disease in a single-patient case report.

Results:: A 49-year-old woman suffered a severe case of Stevens-Johnson syndrome when she was 12 years old, leaving her with bilateral corneal opacification and tympanic membrane perforations with extensive cholesteatoma. Read More

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http://dx.doi.org/10.1177/0003489418823790DOI Listing
January 2019
1 Read

Use of Cyclosporine for the treatment of Steven Johnson Syndrome/ Toxic Epidermal Necrolysis.

J Am Acad Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Massachusetts General Hospital Department of Dermatology. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.09.063DOI Listing
January 2019

Comprehensive assessment of T cell receptor β repertoire in Stevens-Johnson syndrome/toxic epidermal necrolysis patients using high-throughput sequencing.

Mol Immunol 2019 Feb 7;106:170-177. Epub 2019 Jan 7.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Stevens-Johnson syndrome (SJS) /toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse drug reactions characterized by widespread epidermal necrosis. Recent studies have indicated that SJS/TEN is a specific immune reaction regulated by T cells. Certain drug serves as foreign antigens that are presented by major histocompatibility complex (MHC) and recognized by T cell receptors (TCRs), inducing adaptive immune responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183080
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http://dx.doi.org/10.1016/j.molimm.2019.01.002DOI Listing
February 2019
1 Read

Serum and blister-fluid elevation and decreased epidermal content of HMGB1 protein in drug-induced Stevens Johnson syndrome/toxic epidermal necrolysis.

Br J Dermatol 2019 Jan 5. Epub 2019 Jan 5.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

High-mobility group box 1 (HMGB1) is a damage-associated molecular-pattern protein indicative of cell/tissue injury and innate immune response. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are serious, immune-mediated skin-blistering conditions characterised by widespread keratinocyte death and epidermal detachment. The purpose of the study was to determine: a) serum and/or blister-fluid total HMGB1 levels in independent SJS/TEN cohorts: and b) HMGB1 expression in formalin-fixed, paraffin-embedded SJS/TEN skin vs. Read More

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http://dx.doi.org/10.1111/bjd.17610DOI Listing
January 2019

Osimertinib-induced Stevens-Johnson syndrome in a patient with EGFR T790M mutation-positive non-small cell lung cancer.

Lung Cancer 2018 Dec 31. Epub 2018 Dec 31.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 10002, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183073
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http://dx.doi.org/10.1016/j.lungcan.2018.12.030DOI Listing
December 2018
2 Reads

Oxcarbazepine-Induced Stevens-Johnson Syndrome.

Prim Care Companion CNS Disord 2018 Dec 20;20(6). Epub 2018 Dec 20.

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http://dx.doi.org/10.4088/PCC.18l02304DOI Listing
December 2018

Tetracycline Re-exposure-Induced Toxic Epidermal Necrolysis.

Am J Ther 2018 Dec 19. Epub 2018 Dec 19.

Department of Internal Medicine, St. Joseph Mercy Oakland Hospital, Pontiac, MI.

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http://dx.doi.org/10.1097/MJT.0000000000000904DOI Listing
December 2018
3 Reads

Toxic epidermal necrolysis therapeutic standardization: A holistic approach.

Burns 2018 Dec 28. Epub 2018 Dec 28.

Plastic and Reconstructive Surgery Deparment, University Hospital La Fe, Fernando Abril Martorell 1, 46026 Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.burns.2018.11.022DOI Listing
December 2018

Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation.

Am J Case Rep 2018 Dec 21;19:1519-1521. Epub 2018 Dec 21.

Department of Obstetrics Gynecology and Women's Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

BACKGROUND Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. Read More

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http://dx.doi.org/10.12659/AJCR.912123DOI Listing
December 2018

Controversies in drug allergy: Testing for delayed reactions.

J Allergy Clin Immunol 2019 Jan 17;143(1):66-73. Epub 2018 Dec 17.

Dermatology and Allergy Department, Tenon Hospital, Medecine Sorbonne University, Paris, France; Assistance publique-hopitaux de Paris, Paris, France.

Controversies exist with regard to in vivo approaches to delayed immunologically mediated adverse drug reactions, such as exanthem (maculopapular eruption), drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome/toxic epidermal necrolysis, and fixed drug eruptions. In particular, widespread differences exist between regions and practice on the availability and use of intradermal and patch testing, the standard drug concentrations used, the use of additional drugs in intradermal and patch testing to help determine cross-reactivity, the timing of testing in relation to the occurrence of the adverse drug reaction, the use of testing in specific phenotypes, and the use of oral challenge in conjunction with delayed intradermal and patch testing to ascertain drug tolerance. It was noted that there have been advances in the science of delayed T cell-mediated reactions that have shed light on immunopathogenesis and provided a mechanism of preprescription screening in the case of HLA-B*57:01 and abacavir hypersensitivity and HLA-B*15:02 and carbamazepine Stevens-Johnson syndrome/toxic epidermal necrolysis in Southeast Asian subjects. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.10.030DOI Listing
January 2019
1 Read
11.476 Impact Factor

Scoring systems for allergies and asthma in clinical research and practice.

Allergy Asthma Proc 2018 Dec 18. Epub 2018 Dec 18.

Background: Scoring systems are increasingly being developed for various diseases, including asthma and allergic disorders, with the objective of improving the classification of disease severity and the assessment of efficacy of therapeuticmodalities.

Objective: This review provided concise summaries of published scoring systems used for allergic rhinitis, asthma, atopicdermatitis, urticaria, Stevens-Johnson syndrome/toxic epidermal necrolysis, eosinophilic esophagitis, and systemic allergicreactions (anaphylaxis).

Methods: We searched the medical literature between 1985 and 2018 for published scoring systems that have been developedand used in clinical trials or in practice for assessment of asthma and a variety of allergic disorders. Read More

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https://www.ingentaconnect.com/content/10.2500/aap.2019.40.4
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http://dx.doi.org/10.2500/aap.2019.40.4196DOI Listing
December 2018
3 Reads

Adverse Drug Reaction Onsets in Uganda's VigiBase: Delayed International Visibility, Data Quality and Illustrative Signal Detection Analyses.

Pharmaceut Med 2018 17;32(6):413-427. Epub 2018 Nov 17.

3MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Introduction: Developing countries can improve their pharmacovigilance systems by analysing their own medication safety data.

Objective: The aims of this study were to characterize Uganda's reported adverse drug reaction (ADR) onsets in 2012-2015 that were registered on VigiBase by 31 December 2017, to document delays in international visibility and the influence of covariates on this delay from ADR onsets in 2013 + 2014, to examine data quality, and to illustrate analytical approaches for safety data, particularly for patients receiving antiretroviral therapy (ART).

Methods: International delay was defined as elapsed time from complete ADR onset date to entry date on VigiBase, with covariates examined using Cox proportional hazards regression. Read More

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http://dx.doi.org/10.1007/s40290-018-0253-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267548PMC
November 2018
4 Reads

[AN UPDATE ON DIAGNOSIS AND MANAGEMENT OF DRUG ALLERGY].

Authors:
Michiko Aihara

Arerugi 2018 ;67(10):1399-1404

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine.

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http://dx.doi.org/10.15036/arerugi.67.1399DOI Listing
January 2018

Stevens-Johnson syndrome on treatment with sulfasalazine for Crohn's disease: Need for a multidisciplinary approach.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology Section, DBiMis, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.5152/tjg.2018.17728DOI Listing
December 2018

An Interesting Case of Carbamazepine-Induced Stevens-Johnson Syndrome.

Drug Saf Case Rep 2018 Dec 10;6(1). Epub 2018 Dec 10.

Division of Psychiatry, Harare Central Hospital, PO Box ST 14, Southerton, Harare, Zimbabwe.

A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 post-admission, the preferred first-line antidepressant, fluoxetine, became available and the patient was switched from amitriptyline to fluoxetine 20 mg/day. Read More

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http://link.springer.com/10.1007/s40800-018-0095-y
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http://dx.doi.org/10.1007/s40800-018-0095-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288101PMC
December 2018
9 Reads

The presence of HLA-B75, DR13 homozygosity or DR14 additionally increases the risk of allopurinol induced severe cutaneous adverse reactions in HLA-B*58:01 carriers.

J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: Although HLA-B*58:01 is a well-known risk factor for the development of allopurinol-induced severe cutaneous adverse reactions (SCARs), most of the HLA-B*58:01 carriers do not suffer from SCARs despite a long-term use of allopurinol. This suggests that there are other risk factors that determine the fate of HLA-B*58:01 carriers.

Objective: The aim of this study was to investigate the additional genetic factors that increases the risk of allopurinol-induced SCARs in HLA-B*58:01 carriers. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.11.039DOI Listing
December 2018

Deep cutaneous infection in a patient recovering from toxic epidermal necrolysis.

Med Mycol Case Rep 2019 Mar 26;23:26-28. Epub 2018 Oct 26.

Brooke Army Medical Center, 3551 Roger Brooke Drive, San Antonio, TX, USA.

Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22117539183006
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http://dx.doi.org/10.1016/j.mmcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260228PMC
March 2019
7 Reads

Stevens-Johnson syndrome-like reaction without mucosal lesions associated with cyclophosphamide.

Authors:
Yang Lo Chun-An Yao

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):101-103

Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_903_17DOI Listing
December 2018

Novel complication of Flakka: Stevens-Johnson syndrome/Toxic epidermal necrolysis overlap.

Am J Emerg Med 2018 Nov 24. Epub 2018 Nov 24.

Department of Emergency Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.

Flakka, as the newest member of the synthetic cathinone group, is a substance with serious cardiovascular, neurological, psychiatric, infectious effects and addictive potential. There are only a few case reports and laboratory studies in the literature and there is no dermatological side effects reported yet. We present the first Stevens-Johnson syndrome/Toxic epidermal necrolysis (SJS/TEN) overlap case after Flakka use. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.11.037DOI Listing
November 2018

Drug-induced liver injury with skin reactions: Drugs and host risk factors, clinical phenotypes and prognosis.

Liver Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, St. John's Medical College Hospital, Bangalore, India.

While dermatologic manifestations of adverse drug reactions are frequent, drug-induced liver injury is rare. Numerous drugs are implicated in either Drug-Induced Liver Injury or Drug-Induced Skin Injury. However, concomitant Drug-Induced Liver Injury and Drug-Induced Skin Injury are uncommon, not well characterized and appear to be caused by a limited number of drugs. Read More

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http://dx.doi.org/10.1111/liv.14004DOI Listing
December 2018
3 Reads

Drug-induced linear immunoglobulin A bullous dermatosis: A French retrospective pharmacovigilance study of 69 cases.

Br J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

EA 7379 EpiDermE, Université Paris Est Créteil Val de Marne UPEC, Créteil, France.

Aims: Linear immunoglobin A (IgA) bullous dermatosis is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs and highlighted suspected drugs.

Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Read More

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http://dx.doi.org/10.1111/bcp.13827DOI Listing
December 2018
2 Reads

Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.

Lancet 2019 01 30;393(10167):156-167. Epub 2018 Nov 30.

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, National Institute of Health Research Biomedical Research Centre, London, UK.

Background: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)31999-8DOI Listing
January 2019
3 Reads

Toxic epidermal necrolysis after yellow fever vaccination.

An Bras Dermatol 2018 Nov/Dec;93(6):942-943

Medical Residency Program in Dermatology, Faculdade de Medicina de Jundiaí, Jundiaí (SP), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20188237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256206PMC
February 2018

Oral isotretinoin for acne.

Cochrane Database Syst Rev 2018 Nov 24;11:CD009435. Epub 2018 Nov 24.

Emergency Medicine and Evidence Based Medicine, Universidade Federal de São Paulo, Rua Napoleão de Barros, 865, São Paulo, Sao Paulo, Brazil, 04024-002.

Background: Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit associated with socialisation and mental health problems, may affect more than 80% of teenagers. Isotretinoin is the only drug that targets all primary causal factors of acne; however, it may cause adverse effects.

Objectives: To assess efficacy and safety of oral isotretinoin for acne vulgaris. Read More

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http://dx.doi.org/10.1002/14651858.CD009435.pub2DOI Listing
November 2018

Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.

Authors:
Mayumi Ueta

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES183-DES191

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute inflammatory vesiculobullous reactions of the mucosa of the ocular surface, oral cavity, and genitals, and of the skin. Severe ocular complications (SOC) are present in about half of SJS/TEN patients diagnosed by dermatologists. We review our group's findings on the genetic predisposition for and the etiology of SJS/TEN with SOC. Read More

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http://dx.doi.org/10.1167/iovs.17-23537DOI Listing
November 2018
1 Read

Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage.

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES80-DES86

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur in 77% of SJS/TEN patients. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-24019DOI Listing
November 2018
9 Reads

Temporal trends and patterns in carbamazepine use, related severe cutaneous adverse reactions, and HLA-B*15:02 screening: A nationwide study.

Epilepsia 2018 Dec 26;59(12):2325-2339. Epub 2018 Nov 26.

Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Objective: After discovering the association between the HLA-B*15:02 allele and carbamazepine-related severe cutaneous adverse reactions (SCARs), particularly in Southeastern Asian populations, clinical strategies to prevent carbamazepine-related SCARs have changed. We aimed to investigate 10-year trends in carbamazepine use and carbamazepine-related SCARs and to examine the patterns and determinants of HLA-B*15:02 screening in Taiwan.

Methods: A nationwide study was performed using Taiwan's National Health Insurance Research Database. Read More

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http://dx.doi.org/10.1111/epi.14599DOI Listing
December 2018
1 Read

Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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http://doi.wiley.com/10.1111/pde.13719
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http://dx.doi.org/10.1111/pde.13719DOI Listing
November 2018
6 Reads

Major Histocompatibility Complex and Psoriasis.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S79-S80

The Institute of Dermatology and Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei City, China. Electronic address:

Major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) in humans, is one of the most genetically diverse regions in the genome of various species. The human MHC contains about 400 genes in a ∼7.6-Mb span located on the short arm of the chromosomal region 6p21. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10870024183000
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http://dx.doi.org/10.1016/j.jisp.2018.09.006DOI Listing
December 2018
10 Reads

Long-term outcome of using Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) as a drug delivery system for bevacizumab in the treatment of corneal neovascularization.

Ocul Surf 2018 Nov 20. Epub 2018 Nov 20.

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.

Purpose: To report the long-term outcome of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) for delivery of bevacizumab in the treatment of corneal neovascularization (KNV).

Methods: Retrospective, non-comparative, interventional case series of 13 sequential patients treated for KNV at the BostonSight between 2006 and 2017. In all cases, PROSE treatment was initiated for management of ocular surface disease and patients wore PROSE consistently on a daily wear basis prior to bevacizumab treatment. Read More

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http://dx.doi.org/10.1016/j.jtos.2018.11.008DOI Listing
November 2018
14 Reads

Cyclosporine-induced toxic leukoencephalopathy in toxic epidermal necrolysis.

Int J Dermatol 2019 Feb 19;58(2):e36-e38. Epub 2018 Nov 19.

Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://doi.wiley.com/10.1111/ijd.14300
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http://dx.doi.org/10.1111/ijd.14300DOI Listing
February 2019
5 Reads
1.230 Impact Factor

Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Jpn J Clin Oncol 2018 Nov 17. Epub 2018 Nov 17.

Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Japan.

Background: Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma. Read More

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyy172DOI Listing
November 2018
9 Reads

Gastro-intestinal involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis : a retrospective case series.

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor - Albert Chenevier, Assistance Publique - Hôpitaux de Paris (AP-HP), Créteil, France.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by extensive skin and mucosal membrane detachment together with specific visceral involvement. While respiratory tract and ear, nose, and throat mucosal lesions have been comprehensively described, gastro-intestinal (GI) involvement, although previously reported, has been less investigated. Clinical manifestations are non-specific, including ileus, emesis, diarrhea, hematemesis, melena/rectal bleeding, abdominal pain, or dysphagia. Read More

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http://dx.doi.org/10.1111/bjd.17428DOI Listing
November 2018
2 Reads

Propranolol eye drops in patients with corneal neovascularization.

Medicine (Baltimore) 2018 Nov;97(45):e13002

Pediatric Ophthalmology Unit, Niguarda Ca' Granda Metropolitan Hospital, Milan, Italy.

Rationale: Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0001
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http://dx.doi.org/10.1097/MD.0000000000013002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250516PMC
November 2018
9 Reads

Stevens-Johnson syndrome.

Intern Emerg Med 2018 Nov 8. Epub 2018 Nov 8.

Department of ENT and Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Pillaiyarkuppam, Pondicherry, 607402, India.

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http://link.springer.com/10.1007/s11739-018-1981-0
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http://dx.doi.org/10.1007/s11739-018-1981-0DOI Listing
November 2018
4 Reads

Methotrexate-Induced Toxic Epidermal Necrolysis: A Rare Case Report and Review of Literature.

Indian J Crit Care Med 2018 Oct;22(10):740-742

Department of Medical Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Acute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric patients, and it is characterized by the presence of malignant lymphoblasts within the bone marrow and peripheral blood. The treatment of ALL involves induction, consolidation, reinduction, and maintenance therapy. Consolidation therapy in ALL-Berlin-Frankfurt-Münster 90 protocol involves the use of high-dose methotrexate (HDMTX, 5 g/m) over 24 h as continuous infusion. Read More

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http://www.ijccm.org/text.asp?2018/22/10/740/243590
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http://dx.doi.org/10.4103/ijccm.IJCCM_212_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201642PMC
October 2018
6 Reads

Erratum: Successful Treatment of Stevens-Johnson Syndrome with Cyclosporine and Corticosteroid: Correction.

Authors:

Can J Hosp Pharm 2018 Sep-Oct;71(5):292. Epub 2018 Oct 31.

[This corrects the article on p. 272 in vol. 71, PMID: 30186001. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209506PMC
October 2018
1 Read

Idiopathic Stevens-Johnson syndrome and toxic epidermal necrolysis: prevalence and patients characteristics.

J Am Acad Dermatol 2018 Nov 2. Epub 2018 Nov 2.

EA 7379 EpiDermE, Université Paris Est Créteil, France; Department of Dermatology, Hôpital Henri-Mondor, AP-HP, Créteil, France.

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http://dx.doi.org/10.1016/j.jaad.2018.10.058DOI Listing
November 2018
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Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System.

Epilepsia 2018 Dec 5;59(12):2318-2324. Epub 2018 Nov 5.

University of Rhode Island College of Pharmacy, Kingston, Rhode Island.

Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially fatal adverse skin reactions that are most commonly triggered by certain medications. One class of medications that has been highly associated with SJS/TEN reactions is antiepileptic drugs (AEDs). We sought to quantify the risk of SJS/TEN associated with AEDs as a class, as well as individual AEDs, in the United States. Read More

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http://dx.doi.org/10.1111/epi.14591DOI Listing
December 2018
2 Reads

Long-term effect of corneoscleral contact lenses on refractory ocular surface diseases.

Cont Lens Anterior Eye 2018 Oct 30. Epub 2018 Oct 30.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Electronic address:

Purpose: To report the therapeutic effect of corneoscleral contact lenses (CLs) with a diameter of 14.0 mm on the refractory ocular surface diseases.

Methods: Medical records of 13 eyes (of nine patients) attempted for fitting with corneoscleral CLs for the management of the severe refractory ocular surface diseases were retrospectively reviewed including Stevens-Johnson syndrome (SJS; eight eyes) and chronic ocular graft-versus-host disease (GVHD; five eyes). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13670484183088
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http://dx.doi.org/10.1016/j.clae.2018.10.011DOI Listing
October 2018
6 Reads

A response letter to allopurinol-induced toxic epidermal necrolysis and association with HLA-B*5801 in White patients.

Pharmacogenet Genomics 2018 Dec;28(12):268-269

Functional Genomics Group, Genomic Medicine Section, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1097/FPC.0000000000000357DOI Listing
December 2018

Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships.

J Chem Inf Model 2018 Nov 9;58(11):2203-2213. Epub 2018 Nov 9.

Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599 , United States.

Quantitative structure-activity relationships (QSAR) models are often seen as a "black box" because they are considered difficult to interpret. Meanwhile, qualitative approaches, e.g. Read More

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http://pubs.acs.org/doi/10.1021/acs.jcim.8b00450
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http://dx.doi.org/10.1021/acs.jcim.8b00450DOI Listing
November 2018
21 Reads

Generalized bullous fixed-drug eruption secondary to the influenza vaccine.

JAAD Case Rep 2018 Oct 12;4(9):953-955. Epub 2018 Oct 12.

University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.jdcr.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197945PMC
October 2018
1 Read

Corneal limbal stem cell deficiency in children with Stevens-Johnson syndrome.

Am J Ophthalmol 2018 Oct 19. Epub 2018 Oct 19.

Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: To determine the incidence of corneal limbal stem cell deficiency (LSCD) as chronic ocular sequelae in children with Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN) and analyze the factors associated with LSCD development.

Design: Retrospective case series.

Methods: Medical records were reviewed of pediatric patients who had been admitted to Seoul National University Hospital with SJS/TEN and diagnosed as having acute ocular involvement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183060
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http://dx.doi.org/10.1016/j.ajo.2018.10.016DOI Listing
October 2018
11 Reads

[When drugs induce cutaneous lupus erythematosus].

Ugeskr Laeger 2018 Oct;180(41)

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is defined as an adverse reaction to continuous use of a culprit drug. The reaction resolves upon drug withdrawal. More than 50 drugs have been linked to DI-SCLE, and it is estimated, that around 20% of the SCLE cases are drug-induced. Read More

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October 2018
3 Reads