7,673 results match your criteria Toxic Epidermal Necrolysis


Human Oral Mucosal Fibroblasts from Limbal Stem Cell Deficient Patients as an Autologous Feeder Layer for Epithelial Cell Culture.

Curr Eye Res 2022 May 16:1-10. Epub 2022 May 16.

Cells for Sight, University College London, London, UK.

Purpose: To investigate if human oral mucosal fibroblasts (HOMF) from patients with limbal stem cell deficiency (LSCD) can be used as an autologous feeder layer to support the culture of epithelial cells for potential clinical use.

Methods: HOMF were isolated from oral mucosal biopsies obtained from the following groups of patients with LSCD: aniridia, mucous membrane pemphigoid (MMP), Stevens-Johnson syndrome (SJS), and ectodermal dysplasia (ED). The ability of these cells to support the culture of human limbal epithelial cells (HLE) was compared to that of HOMF from non-LSCD donors and 3T3s commonly used to culture epithelial cells for use in the clinic to treat LSCD. Read More

View Article and Full-Text PDF

Carbamazepine Induced Stevens-Johnson Syndrome That Developed into Toxic Epidermal Necrolysis: Review of the Literature.

Case Rep Dermatol Med 2022 6;2022:6128688. Epub 2022 May 6.

An-Najah National University Hospital, Nablus, State of Palestine.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are both skin diseases believed to be following the pattern of a type IV hypersensitivity mechanism, which can be triggered by infectious agents or administration of a variety of drugs as part of the spectrum of severe cutaneous adverse reactions (SCARs). Fever and blisters, that peel forming painful raw areas, are early symptoms of this condition, and complications such as dehydration, sepsis, pneumonia, and multiple organ failure are typically seen during the course of the disease. . Read More

View Article and Full-Text PDF

Clinical characteristics of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A single-center study.

Asia Pac Allergy 2022 Apr 21;12(2):e17. Epub 2022 Apr 21.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions, most commonly triggered by medications, characterized by extensive necrosis and detachment of the epidermis.

Objective: We investigated the differences in clinical characteristics of drug-induced SJS/TEN depending on the type of drug in a single center.

Methods: The relevance of sex, age, culprit drugs, clinical features, courses, treatment options, and follow-up results were retrospectively evaluated in patients diagnosed with drug-induced SJS/TEN at Pusan National University Hospital between 2008 and 2019. Read More

View Article and Full-Text PDF

Stevens-Johnson Syndrome Following Vancomycin and Linezolid: A Real-World Analysis of Post-Marketing Surveillance Data.

Front Pharmacol 2022 28;13:872854. Epub 2022 Apr 28.

Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Stevens-Johnson syndrome (SJS) has been reported as a serious adverse effect in patients treated with vancomycin or linezolid, and there is currently a lack of real-world studies comparing specific differences in adverse effects of SJS. According to the FDA's Adverse Event Reporting System (FAERS), from January 2004 to July 2021, the data of suspected SJS after the use of vancomycin and linezolid were analyzed by imbalance and Bayesian analysis. The onset time, fatality rate and hospitalization rate of vancomycin-associated SJS and linezolid-associated SJS were also investigated. Read More

View Article and Full-Text PDF

An Updated Review of Genetic Associations With Severe Adverse Drug Reactions: Translation and Implementation of Pharmacogenomic Testing in Clinical Practice.

Front Pharmacol 2022 25;13:886377. Epub 2022 Apr 25.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Keelung, Taiwan.

Adverse drug reactions (ADR) remain the major problems in healthcare. Most severe ADR are unpredictable, dose-independent and termed as type B idiosyncratic reactions. Recent pharmacogenomic studies have demonstrated the strong associations between severe ADR and genetic markers, including specific HLA alleles (e. Read More

View Article and Full-Text PDF

Genetic markers for methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Eur Acad Dermatol Venereol 2022 06;36(6):764

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

View Article and Full-Text PDF

Case Series of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Nivolumab and Nivolumab/ Ipilimumab Combination Therapy in Metastatic Melanoma.

J Drugs Dermatol 2022 May;21(5):529-530

Nivolumab (anti PD-1 antibody) and ipilimumab (anti CTLA-4 antibody) are immune checkpoint inhibitors (ICI) that effectively stimulate the native T cell response and lead to an antitumor response. The medications have been approved for the treatment of metastatic melanoma. However, ICIs are associated with higher risk for cutaneous immune-related adverse events (irAEs). Read More

View Article and Full-Text PDF

[Translated article] Use of Intravenous Immunoglobulins and Systemic Corticosteroids in Patients With Toxic Epidermal Necrolysis: Experience of a Hospital in Mexico City.

Actas Dermosifiliogr 2022 Mar 8;113(3):T294-T299. Epub 2022 Feb 8.

División de Dermatología, Hospital General Dr. Manuel Gea González, Ciudad de México, Mexico.

Toxic epidermal necrolysis is the most serious mucocutaneous adverse drug reaction. Multidisciplinary treatment and withdrawal of the causative drug are key to reducing mortality. Few studies have analyzed the use of systemic corticosteroids and intravenous immunoglobulins (IVIG) in patients with toxic epidermal necrolysis in Latin America. Read More

View Article and Full-Text PDF

Use of Intravenous Immunoglobulins and Systemic Corticosteroids in Patients with Toxic Epidermal Necrolysis: Experience of a Hospital in Mexico City.

Actas Dermosifiliogr 2022 Mar 10;113(3):294-299. Epub 2021 Nov 10.

División de Dermatología, Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Toxic epidermal necrolysis is the most serious mucocutaneous adverse drug reaction. Multidisciplinary treatment and withdrawal of the causative drug are key to reducing mortality. Few studies have analyzed the use of systemic corticosteroids and intravenous immunoglobulins (IVIG) in patients with toxic epidermal necrolysis in Latin America. Read More

View Article and Full-Text PDF

Carbamazepine-modified HLA-A*24:02-bound peptidome: Implication of CORO1A in skin rash.

Int Immunopharmacol 2022 May 5;109:108804. Epub 2022 May 5.

Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, China. Electronic address:

Background: Previous studies have demonstrated that human leukocyte antigen (HLA)-A*24:02 is a common genetic risk factor for antiepileptic drug-induced skin rash, while HLA-B*15:02 is a specific risk factor for carbamazepine (CBZ)-induced Stevens Johnson syndrome and toxin epidermal necrolysis. The HLA-B*15:02 allele can alter the repertoire of endogenous peptides to trigger CBZ-induced hypersensitivity. However, it is uncertain whether HLA-A*24:02 could produce alterations in the peptide repertoire during treatment with antiepileptic drugs. Read More

View Article and Full-Text PDF

Fuchs Syndrome with Isolated Oral Mucosa Lesions due to Severe Herpes Simplex Cheilitis in a Patient with Idiopathic Thrombocytopenic Purpura.

Eur J Case Rep Intern Med 2022 4;9(4):003278. Epub 2022 Apr 4.

Thun General Hospital, Thun, Switzerland.

Stevens-Johnson syndrome (SJS) is a severe dermatological disease classically characterized by erythematous target lesions and mucosal involvement. Fuchs syndrome is an incomplete presentation of SJS which has oral, conjunctival and genital manifestations but no skin lesions. To the best of our knowledge, our case of Fuchs syndrome in an 80-year-old man is the first such case related to herpes simplex virus (HSV)-1 infection to be described. Read More

View Article and Full-Text PDF

Reply to: "Photodistributed toxic epidermal necrolysis in association with lamotrigine and tanning bed exposure".

JAAD Case Rep 2022 May 20;23:164-165. Epub 2022 Jan 20.

Department of Dermatology, Stanford University School of Medicine, Palo Alto, California.

View Article and Full-Text PDF

Complete response to pembrolizumab for metastatic urothelial carcinoma in the renal pelvis of allograft kidney.

IJU Case Rep 2022 May 25;5(3):199-202. Epub 2022 Mar 25.

Department of Urology Jichi Medical University Tochigi Japan.

Introduction: We present a case of urothelial carcinoma in a renal allograft successfully treated with pembrolizumab.

Case Presentation: A 39-year-old woman presented with nausea and anorexia 9 years after a renal transplantation. Positron emission tomography revealed a neoplasm of the renal pelvis of the allograft and multiple lymph nodes with peritoneal metastasis. Read More

View Article and Full-Text PDF

Photodistributed Toxic Epidermal Necrolysis: Case Report and Review of Current Literature.

JAMA Dermatol 2022 May 4. Epub 2022 May 4.

Department of Dermatology, University of North Carolina at Chapel Hill.

Importance: Cases of photodistributed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been infrequently reported since the first documented case in 1989. This emerging clinical entity and its underlying mechanism have yet to be fully characterized.

Objective: To report a case of photodistributed SJS/TEN and highlight similarities to other cases reported in the literature. Read More

View Article and Full-Text PDF

Successful Treatment of Carbamazepine-Induced Toxic Epidermal Necrolysis With Clinical Gastrointestinal Involvement: A Case Report.

Front Pediatr 2022 13;10:834037. Epub 2022 Apr 13.

Surgical Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam.

Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare and life-threatening disease of the skin and mucosal surfaces. Although gastrointestinal manifestations in adults are potential prognostic factors for disease severity, there are limited data on such cases and their standard management in the pediatric population.

Case Presentation: We herein report the case of an 8-year-old girl with a 1-year history of epilepsy, who presented with bilateral conjunctivitis and progressively widespread bullous, and pruritic eruption based on erythematous skin after administration of carbamazepine. Read More

View Article and Full-Text PDF

Purpura fulminans, TEN, and disseminated herpes simplex: An unexpected combination.

Clin Case Rep 2022 Apr 26;10(4):e05784. Epub 2022 Apr 26.

Department of Surgical Sciences Plastic Surgery Uppsala University Uppsala Sweden.

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and purpura fulminans (PF) are all rare conditions. A combination of these 3 conditions together with a viral infection is very rare. A 52-year-old, previously healthy woman which developed SJS, potentially due to a reaction to CT contrast, although this is still unknown. Read More

View Article and Full-Text PDF

COVID-19: A Curious Abettor in the Occurrence of Stevens-Johnson Syndrome.

Cureus 2022 Mar 28;14(3):e23562. Epub 2022 Mar 28.

Department of Pulmonary and Critical Care Medicine, Hartford Hospital, Hartford, USA.

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are immune-mediated life-threatening skin diseases. The condition is known to be caused by various infections, drugs (mainly antibiotics), or can be idiopathic. Amidst the novel coronavirus 2019 (COVID-19) pandemic, there is an increasing number of SJS/TEN cases being reported. Read More

View Article and Full-Text PDF

Relationship between Atopic Disease and Acute Ocular and Systemic Outcomes in Patients with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

Ocul Immunol Inflamm 2022 Apr 29:1-5. Epub 2022 Apr 29.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Objective: To describe the relationship between history of atopic disease on systemic and ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN).

Methods: Retrospective chart review of patients with SJS/TEN patients. Those with and without prior atopic diagnosis were compared. Read More

View Article and Full-Text PDF

[Treatment with Intravenous Acyclovir Desensitization for Severe Acyclovir Allergy: A Case of Herpes Encephalitis].

Mikrobiyol Bul 2022 Apr;56(2):371-376

University of Health Sciences Adana City Training and Research Hospital Clinic of Infectious Diseases and Clinical Microbiology, Adana, Turkey.

Herpes simplex virus (HSV) is a sporadic viral encephalitis agent that causes high mortality and morbidity, accompanied by neurological dysfunction findings. Acyclovir is the only antiviral treatment option that should be initiated in all patients with suspected encephalitis as soon as possible. Acyclovir is rarely possible to cause allergic reactions. Read More

View Article and Full-Text PDF

Severe cutaneous adverse reactions associated with systemic ivermectin: A pharmacovigilance analysis.

J Dermatol 2022 Apr 27. Epub 2022 Apr 27.

Division of Dermatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv, Israel.

Despite poor evidence, the antiparasitic ivermectin has been advocated as a potential COVID-19 therapy. This has led to a rise in calls to poison-control centers by people self-medicating with ivermectin, which is sold over the counter for veterinary uses. We aimed to investigate the association between severe cutaneous adverse reactions (SCARs) and ivermectin. Read More

View Article and Full-Text PDF

Rare case of Stevens-Johnson syndrome with bronchiolitis obliterans as a chronic complication.

BMJ Case Rep 2022 Apr 25;15(4). Epub 2022 Apr 25.

Department of Pediatrics, Osaka Red Cross Hospital, Osaka, Japan.

A young girl in her teens presented with fever, rashes and various mucocutaneous symptoms. Flat erythematous macules were seen mainly on the limbs, without blisters or skin detachments. The lips were swollen with crusts and haemorrhage. Read More

View Article and Full-Text PDF

Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment.

Am J Ophthalmol Case Rep 2022 Jun 14;26:101520. Epub 2022 Apr 14.

BostonSight, 464 Hillside Ave., Suite 205, Needham, MA, 02494, USA.

Purpose: To report two cases demonstrating the regression of corneal neovascularization and clearing of corneal opacification in patients with Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) undergoing prosthetic replacement of the ocular surface ecosystem (PROSE) treatment.

Observations: Four eyes of 2 patients were analyzed. Regression of neovascularization and clearing of corneal opacification was observed in both patients. Read More

View Article and Full-Text PDF

Cytokeratin profile and keratinocyte gene expression in keratinized lid margins of patients with chronic Stevens-Johnson syndrome.

Graefes Arch Clin Exp Ophthalmol 2022 Apr 23. Epub 2022 Apr 23.

Centre for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Centre (BHERC), LV Prasad Eye Institute, Road No.2, Banjara Hills, Hyderabad, 500034, Telangana, India.

Purpose: To study the cytokeratin profile and keratinization-related gene expression in keratinized lid margins of chronic Stevens-Johnson syndrome (SJS) patients.

Methods: Posterior eyelid margins from 24 chronic SJS patients undergoing mucous membrane grafting and six healthy margins (orbital exenteration, fresh body donors) were studied using immunofluorescence staining (CK10, CK1, filaggrin, transglutaminase 1 (TGM1), (CK19, MUC5AC)) and quantitative PCR (keratinization-related genes-HBEGF, KGF, EGF, TGFα, TGFβ, and TNFα). The staining and gene expression were studied separately in the lid margin epidermis (LME) and lid margin conjunctiva (LMC). Read More

View Article and Full-Text PDF

WGCNA-Based DNA Methylation Profiling Analysis on Allopurinol-Induced Severe Cutaneous Adverse Reactions: A DNA Methylation Signature for Predisposing Drug Hypersensitivity.

J Pers Med 2022 Mar 24;12(4). Epub 2022 Mar 24.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China.

Background: The role of aberrant DNA methylation in allopurinol-induced severe cutaneous adverse reactions (SCARs) is incompletely understood. To fill the gap, we analyze the DNA methylation profiling in allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients and identify the DNA methylation signature for predisposing allopurinol hypersensitivity.

Methods: Genome-scale methylation analysis was conducted using the Illumina HumanMethylation450 BeadChip. Read More

View Article and Full-Text PDF

Bosutinib-Induced Stevens-Johnson Syndrome and Evidence of Tolerance to a Structurally Dissimilar Tyrosine Kinase Inhibitor.

Cureus 2022 Mar 18;14(3):e23288. Epub 2022 Mar 18.

Division of Pulmonary, Allergy, and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, USA.

Bosutinib is a breakpoint cluster region-Abelson gene (BCR-ABL) tyrosine kinase inhibitor (TKI) used for the treatment of chronic myeloid leukemia (CML). Patients on TKIs may develop severe cutaneous adverse reactions (SCARs). A 73-year-old female with CML treated with a second-generation TKI (bosutinib) was evaluated after developing fever and a maculopapular exanthema with skin-peeling affecting her lips, oral mucosa, and genitals 10 days after starting the medication. Read More

View Article and Full-Text PDF

An Unusual TEN-Like Presentation of Juvenile Bullous Pemphigoid: A Diagnostic Challenge.

Case Rep Dermatol Med 2022 11;2022:8507156. Epub 2022 Apr 11.

Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Bullous pemphigoid (BP) is an acquired autoimmune bullous disorder rarely seen in the pediatric population. It usually presents as large and tense bullae, predominantly distributed in the acral areas. Herein, we describe a case of childhood BP with an atypical presentation mimicking toxic epidermal necrolysis (TEN). Read More

View Article and Full-Text PDF

Antibody-Negative Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS) in a Patient with Follicular Lymphoma Accompanied by an Excess of Peripheral Blood CD8+ Lymphocytes.

Curr Oncol 2022 Mar 28;29(4):2395-2405. Epub 2022 Mar 28.

Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, 44791 Bochum, Germany.

Paraneoplastic autoimmune multiorgan syndrome (PAMS) is a life-threatening autoimmune disease associated with malignancies. Here, we present a patient initially misdiagnosed with "chronic" Stevens-Johnson syndrome. Over a year later, the patient was diagnosed with stage IV follicular lymphoma and treated with an anti-CD20 antibody. Read More

View Article and Full-Text PDF