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    6310 results match your criteria Toxic Epidermal Necrolysis

    1 OF 127

    Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder.
    Prim Care Companion CNS Disord 2018 Mar 29;20(2). Epub 2018 Mar 29.
    Saga University, Department of Psychiatry, Nabeshima 5-1-1, Saga-city, Saga 849-8501, Japan.
    Background: Although lamotrigine may be useful for treating patients with treatment-resistant bipolar disorder, some lamotrigine-associated adverse effects, including mild to moderate skin rash, may prevent the continuation of treatment.

    Methods: We investigated lamotrigine rechallenge for the treatment of bipolar disorder. The present study was based on retrospective chart review of outpatients with bipolar disorder (DSM-5 criteria) who visited the hospital's psychiatric department between July 2011 and August 2017. Read More

    [Treatment of severe cutaneous adverse drug reactions].
    Ann Dermatol Venereol 2018 Apr 13. Epub 2018 Apr 13.
    Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; Centre de référence des dermatoses bulleuses toxiques et toxidermies graves (filière FIMARAD), hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France.

    Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Call for Optimum Patient Stratification and Theranostics via Pharmacogenomics.
    Annu Rev Genomics Hum Genet 2018 Apr 13. Epub 2018 Apr 13.
    South East Asian Pharmacogenomics Research Network (SEAPHARM).
    The Global Genomic Medicine Collaborative, a multinational coalition of genomic and policy experts working to implement genomics in clinical care, considers pharmacogenomics to be among the first areas in genomic medicine that can provide guidance in routine clinical practice, by linking genetic variation and drug response. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe life-threatening reactions to medications with a high incidence worldwide. Genomic screening prior to drug administration is a key opportunity and potential paradigm for using genomic medicine to reduce morbidity and mortality and ultimately eliminate one of the most devastating adverse drug reactions. Read More

    An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.
    J Immunol Res 2018 13;2018:6431694. Epub 2018 Feb 13.
    Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou, Keelung, Taiwan.
    Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Read More

    Chem Res Toxicol 2018 Apr 12. Epub 2018 Apr 12.
    Dysregulation in the expression of microRNAs (miRNAs), single stranded RNAs which regulate gene expression, has been associated with diseases such as Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN), although their cellular origin has not been explored. Thus, the focus of this work was to study expression patterns of reported miRNAs involved in T - cell activation following drug-specific stimulation in peripheral blood mononuclear cells (PBMCs) and drug specific CD4+ T-cell clones (TCC) from patients with different cutaneous manifestations of delayed-type drug hypersensitivity reactions. CD4+ T - cells from hypersensitive patients were stimulated to proliferate, secreted cytokines (IFN-γ and IL-22), cytolytic molecules (Granzyme B) and up-regulate miRNAs 24 to 48 h after drug exposure. Read More

    A retrospective investigation of HLA-B*5801 in hyperuricemia patients in a Han population of China.
    Pharmacogenet Genomics 2018 Apr 10. Epub 2018 Apr 10.
    Functional Genomics Group, Genomic Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.
    Background: Hyperuricemia and gout have become increasingly prevalent in China. Allopurinol is an effective urate-lowering therapy, but it has severe side effects. HLA-B*5801 is highly associated with the allopurinol-induced toxic epidermal necrolysis and Stevens-Johnson syndrome. Read More

    Retrospective review of paediatric case reports of Stevens-Johnson syndrome and toxic epidermal necrolysis with lamotrigine from an international pharmacovigilance database.
    BMJ Paediatr Open 2017 4;1(1):e000039. Epub 2017 Aug 4.
    Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UK.
    Objectives: This study aims to characterise paediatric reports with lamotrigine (LTG) and Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN), and to explore whether potential risk factors can be identified.

    Design: This is a retrospective review of suspected adverse drug reaction (ADR) reports. Reported time from LTG start to SJS/TEN onset, indication for use and dose was explored. Read More

    CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment.
    Pharmgenomics Pers Med 2018 29;11:51-58. Epub 2018 Mar 29.
    Department of Neurology, Catholic University of Parana (PUCPR), Curitiba, Brazil.
    Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and status epilepticus, and effective in controlling focal seizures with and without tonic-clonic generalization and status epilepticus. The metabolization of PHT is carried out by two oxidative cytochrome P450 enzymes CYP2C9 and CYP2C19; 90% of this metabolization is done by CYP2C9 and the remaining 10% by CYP2C19. Genetic polymorphism of CYP2C9 may reduce the metabolism of PHT by 25-50% in patients with variants *2 and *3 compared to those with wild-type variant *1. Read More

    A meta-analysis of cyclosporine treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis.
    J Inflamm Res 2018 28;11:135-142. Epub 2018 Mar 28.
    Department of Paediatrics, National University Hospital, National University Health System, Singapore.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are dermatologic emergencies with high morbidity and mortality risk. Cyclosporine, an immunomodulatory agent, is sometimes used off-label, and its role continues to be debated. This meta-analysis aimed to provide an update of current evidence and to clarify the role of cyclosporine in SJS/TEN treatment better. Read More

    Epidermal necrolysis French national diagnosis and care protocol (PNDS; protocole national de diagnostic et de soins).
    Orphanet J Rare Dis 2018 Apr 10;13(1):56. Epub 2018 Apr 10.
    Dermatology Department, AP-HP, Henri Mondor Hospital, 51 avenue du maréchal de Lattre de Tassigny, 94000, Créteil, France.
    Epidermal necrolysis (EN) encompasses Stevens-Johnson syndrome (SJS, < 10% of the skin affected), Lyell syndrome (toxic epidermal necrolysis, TEN, with ≥30% of the skin affected) and an overlap syndrome (10 to 29% of the skin affected). These rare diseases are caused, in 85% of cases, by pharmacological treatments, with symptoms occurring 4 to 28 days after treatment initiation. Mortality is 20 to 25% during the acute phase, and almost all patients display disabling sequelae (mostly ocular impairment and psychological distress). Read More

    Treatment of toxic epidermal necrolysis by a multidisciplinary team. A review of literature and treatment results.
    Burns 2018 Apr 4. Epub 2018 Apr 4.
    Department of Dermatology and Skin Science, University of British Columbia, Canada.
    Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are mucocutaneous hypersensitivity reactions, usually to drugs or their metabolites. TEN is the most severe involving greater than 30% of the total body surface area (TBSA). Management of these patients usually benefits from a large multidisciplinary team for both wound and medical management. Read More

    Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis.
    Int Arch Allergy Immunol 2018 Apr 3. Epub 2018 Apr 3.
    Background: Acetaminophen is the most commonly used antipyretic in children. However, there are limited data assessing hypersensitivity reactions related to acetaminophen usage.

    Objectives: To conduct a systematic review to characterize reported reactions to acetaminophen in adults and children, and perform a meta-analysis to assess the prevalence of acetaminophen hypersensitivity in children with a suspected acetaminophen allergy. Read More

    Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population.
    JAMA Neurol 2018 Apr 2. Epub 2018 Apr 2.
    RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
    Importance: Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated.

    Objective: To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs. Read More

    and Oxcarbazepine-Induced DRESS in a Patient With Seizures and Complete Deletion.
    Pediatrics 2018 Apr;141(Suppl 5):S434-S438
    Clinical Pharmacogenomics Service,
    Oxcarbazepine is an antiepileptic drug (AED) commonly used as a first-line treatment option for focal epilepsy. Several AEDs, including carbamazepine, oxcarbazepine, and phenytoin are associated with various delayed-hypersensitivity reactions such as drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, or toxic epidermal necrolysis. The Food and Drug Administration-approved label for oxcarbazepine currently presents information regarding a pharmacogenomic association with the HLA antigen allele and hypersensitivity reactions in certain ancestry groups with a high incidence of this allele. Read More

    A polymicrobial fungal outbreak in a regional burn center after Hurricane Sandy.
    Am J Infect Control 2018 Mar 30. Epub 2018 Mar 30.
    The Johns Hopkins University, School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, Baltimore, MD.
    Objective: To describe a polymicrobial fungal outbreak after Hurricane Sandy.

    Design: An observational concurrent outbreak investigation and retrospective descriptive review.

    Setting: A regional burn intensive care unit that serves the greater Baltimore area, admitting 350-450 burn patients annually. Read More

    Histopathology of Cutaneous Inflammatory Disorders in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):115-149
    1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
    Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Read More

    Trichloroethylene Hypersensitivity Syndrome: Should Be Considered When Diagnosing DRESS Syndrome.
    J Korean Med Sci 2018 Apr 2;33(14):e106. Epub 2018 Apr 2.
    Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.
    Trichloroethylene (TCE) is an organic solvent that is used for degreasing and removing impurities from metal parts. However, this solvent's characteristics and hypersensitivity can produce clinical patterns and laboratory data that mimic drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. Thus, exposure confirmation is critical to making an accurate diagnosis. Read More

    The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.
    J Immunol Res 2018 11;2018:4320195. Epub 2018 Feb 11.
    Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
    Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. Read More

    Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma.
    Case Rep Oncol 2018 Jan-Apr;11(1):119-124. Epub 2018 Feb 15.
    Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands.
    Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. Read More

    Selected presentations of lip enlargement: clinical manifestation and differentiation.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):18-25. Epub 2018 Feb 20.
    Department of Oral Surgery, Poznan University of Medical Sciences, Poznan, Poland.
    Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. Read More

    Vancomycin-Induced Stevens-Johnson Syndrome in a Boy Under 2 Years Old: An Early Diagnosis by Granulysin Rapid Test.
    Front Pediatr 2018 13;6:26. Epub 2018 Mar 13.
    School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Stevens-Johnson syndrome (SJS) is a life-threatening disease, which is mainly ascribed to drugs, such as sulfonamides and psychoepileptics. In this article, we present a pediatric case of vancomycin-induced SJS and an alternative diagnostic algorithm. The patient presented with multiple target-like rashes and vesicles throughout the whole body after receiving vancomycin. Read More

    A New Search Method Using Association Rule Mining for Drug-Drug Interaction Based on Spontaneous Report System.
    Front Pharmacol 2018 9;9:197. Epub 2018 Mar 9.
    Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
    Adverse events (AEs) can be caused not only by one drug but also by the interaction between two or more drugs. Therefore, clarifying whether an AE is due to a specific suspect drug or drug-drug interaction (DDI) is useful information for proper use of drugs. Whereas previous reports on the search for drug-induced AEs with signal detection using spontaneous reporting systems (SRSs) are numerous, reports on drug interactions are limited. Read More

    Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies.
    J Immunol Res 2018 17;2018:5376476. Epub 2018 Jan 17.
    Department of Dermatology, College of Medicine, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, Taiwan.
    Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite). Differentiating SCARs from other more commonly seen reactions with a better outcome help prevent discontinuation of therapy and inappropriate use of systemic immunosuppressants for presumable allergic reactions, of which will affect the clinical outcome. Read More

    Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management.
    Curr Allergy Asthma Rep 2018 Mar 24;18(4):26. Epub 2018 Mar 24.
    Department of Rheumatology, Immunology and Allergology, University Hospital and University of Bern, Bern, Switzerland.
    Purpose Of Study: Immune-mediated adverse drug reactions occur commonly in clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated hypersensitivity, and severe cutaneous adverse drug reactions (SCAR). SCARs represent an uncommon but potentially life-threatening form of delayed T cell-mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis (AGEP) to drug reaction with eosinophilia with systemic symptoms (DRESS), to the most severe form of illness, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis-like cutaneous presentation of chikungunya fever: A case series.
    Pediatr Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Pediatrics, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
    Chikungunya fever is a benign, self-limiting, acute viral illness. An epidemic occurred in New Delhi, India, in August and September 2016. We observed many cases with atypical cutaneous features mimicking Stevens-Johnson syndrome and toxic epidermal necrolysis during this epidemic, especially in infants and children. Read More

    The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison to the USA FDA Label.
    Clin Pharmacol Ther 2018 Mar 23. Epub 2018 Mar 23.
    Chang Gung Memorial Hospital, Linkou, Taiwan.
    Specific ethnic genetic backgrounds associated with risk of Stevens-Johnson syndrome/toxic epidermal necrolysis(SJS/TEN) especially in Asians. However, there have been no large cohort, multiple-country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998-2017. Read More

    [Severe skin reactions due to new medications].
    Hautarzt 2018 Apr;69(4):278-289
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Universitätsklinik für Dermatologie und Venerologie, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and a specific form of hypersensitivity syndrome which is nowadays called "drug reaction with eosinophilia and systemic symptoms" (DRESS) are severe, mainly drug-induced skin reactions. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as drug reaction, in total only about three quarters of the cases are actually caused by drugs. Read More

    Hemophagocytic lymphohistiocytosis in an infant with multiple triggers!!
    Asian J Transfus Sci 2018 Jan-Jun;12(1):85-88
    Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, New Delhi, India.
    Hemophagocytic lymphohistiocytosis (HLH) is a disorder of immune dysregulation secondary to a massive unregulated cytokine storm and its downstream consequences. HLH is being increasingly recognized as a cause of pyrexia of unknown origin, unexplained cytopenias, and hepatic dysfunction. However, this potentially treatable condition is often missed due to lack of suspicion, variable, and nonspecific presentations, inability to fulfil all the diagnostic criteria and availability of diagnostic tests in resource limited settings. Read More

    Mycoplasma pneumoniae-related erythema multiforme: clinical and histological features. A single center series of 33 cases compared to 100 cases induced by other causes.
    J Am Acad Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Dermatology department, AP-HP, Henri Mondor hospital, Créteil; EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val de Marne (UPEC), Creteil; Referral center for toxic bullous diseases, AP-HP, Henri Mondor hospital, Créteil; Université Paris Est-Créteil UPEC, Créteil.
    Background: Mycoplasma pneumoniae (MP) infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of MP-related EM (MP-EM) have been poorly described in the literature.

    Objective: To highlight differences between MP-EM and non-MP-EM. Read More

    Selective use of cyclosporine for Stevens-Johnson syndrome / toxic epidermal necrolysis may exclude patients with poor prognostic factors.
    J Invest Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:

    Toxic Epidermal Necrolysis: A Dermatologic Emergency and the Role of the Oral and Maxillofacial Surgeon.
    J Oral Maxillofac Surg 2018 Feb 23. Epub 2018 Feb 23.
    Associate Program Director, Department of Oral and Maxillofacial Surgery, Nassau University Medical Center, East Meadow, NY.
    Toxic epidermal necrolysis (TEN) is a rare and severe mucocutaneous disorder characterized by mucosal and epidermal necrosis and sloughing. This potentially life-threatening condition, together with the less severe Stevens-Johnson syndrome, is commonly caused by an immunologic reaction to medications and can lead to many long-term complications. The disorder initially presents with fever, malaise, and painful mucosal ulcerations (most commonly oral) but progresses to widespread cutaneous lesions. Read More

    Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.
    J Immunol Res 2018 10;2018:2780272. Epub 2018 Jan 10.
    Department of Community Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    The ∗ allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. Read More

    Association Between HLA-B*1301 and Dapsone-Induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-analysis.
    JAMA Dermatol 2018 Apr;154(4):441-446
    Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
    Importance: Dapsone-induced hypersensitivity syndrome (DHS) is a life-threatening adverse drug reaction. Based on available epidemiologic studies, HLA genotypes may play an important role in DHS.

    Objective: To assess the association between HLA-B*1301 and dapsone-induced cutaneous adverse drug reactions (cADRs). Read More

    Anterior segment optical coherence tomography findings in type I Boston keratoprosthesis.
    Arq Bras Oftalmol 2018 Jan-Feb;81(1):42-46
    Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Purpose: To report the results of high-resolution anterior segment optical coherence tomography of patients implanted with a type 1 Boston keratoprosthesis (KPro).

    Methods: The retrospective study cohort included 11 eyes of 11 patients (average age, 58.4 years; range, 34-83 years). Read More

    Severe eye complications from toxic epidermal necrolysis following initiation of Nevirapine based HAART regimen in a child with HIV infection: a case from Cameroon.
    BMC Pediatr 2018 03 13;18(1):108. Epub 2018 Mar 13.
    School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
    Background: Toxic epidermal necrolysis (TEN) is a rare life threatening dermatological disorder characterized by extensive epidermal detachment and erosion of mucous membranes. It is typically a side effect of some medications. Nevirapine, a nonnucleoside reverse transcriptase inhibitor (NNRTI) is one of the frequently used components of highly active antiretroviral therapy (HAART). Read More

    induced mucositis without rash in an 11-year-old boy.
    Clin Case Rep 2018 Mar 6;6(3):551-552. Epub 2018 Feb 6.
    Department of PediatricsSaint Barnabas Medical CenterLivingstonNew Jersey.
    is a frequent cause of childhood pneumonia, and extrapulmonary manifestations may be noted at the time of infection. While has long been associated with Stevens-Johnson syndrome, a separate diagnostic entity, induced rash and mucositis (MIRM), has recently been proposed to better characterize the rash and severe mucositis that some patients exhibit. A subset of patients with MIRM will have mucositis without skin rash. Read More

    Tumor necrosis factor alpha inhibitors in the treatment of toxic epidermal necrolysis.
    Cutis 2018 Jan;101(1):E15-E21
    Department of Dermatology, Louisiana State University Health Sciences Center, New Orleans, USA.
    Toxic epidermal necrolysis (TEN) is a rare, life-threatening adverse drug reaction for which there is no standardized or consistently effective treatment. Due to a greater understanding of disease pathogenesis and the identification of tumor necrosis factor (TNF) α as a mediator of keratinocyte death, TNF-α antagonists have been used in the treatment of TEN. Specifically, infliximab and etanercept have been shown to be effective at halting disease progression. Read More

    Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome.
    Obstet Gynecol 2018 Apr;131(4):723-726
    Departments of Obstetrics and Gynecology and Reproductive Endocrinology and Infertility, Naval Medical Center San Diego, San Diego, California.
    Background: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.

    Case: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. Read More

    Temporary Abdominal Closure Combined With an Irrigating System Utilizing Hypochlorous Acid Solution to Decrease Abdominal Mucopurulence.
    Eplasty 2018 26;18:e12. Epub 2018 Feb 26.
    Department of Surgery, Maricopa Integrated Health System, Phoenix, AZ.
    Leaving the abdominal cavity open is a well-described and frequently utilized technique in the treatment of severe intra-abdominal sepsis. Irrigation through a negative pressure wound therapy device is a technique employed to assist in the closure of wounds as well as the reduction of bacterial contamination. Furthermore, hypochlorous acid has been found to be safe and effective in microorganismal elimination from extremity wounds. Read More

    Overexpression of cytotoxic proteins correlates with liver function impairment in patients with drug reaction with eosinophilia and systemic symptoms (DRESS).
    Eur J Dermatol 2018 Feb;28(1):13-25
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
    Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterised by skin rash and multivisceral involvement. The liver is the organ most frequently affected and the degree of liver function impairment often correlates with the mortality rate of DRESS. We aimed to examine the expression of cytotoxic proteins, including soluble Fas ligand (sFasL), TNF-α, granulysin, perforin, and granzyme B in the sera and skin lesions of patients with DRESS and evaluate their clinical significance. Read More

    A Rare Case Report of Toxic Epidermal Necrolysis due to Ofloxacin.
    Curr Drug Saf 2018 Mar 2. Epub 2018 Mar 2.
    Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar - 364001 (Gujarat), India.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet uncleared. A 45-year-old male patient by chance on re-exposure to Ofloxacin developed severe cutaneous adverse drug reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN were lead him to death. Read More

    Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review.
    Medicine (Baltimore) 2018 Jan;97(1):e9112
    Department of Children's Critical Care Medicine, Xin-Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Rationale: Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. SJS in children is not common but potentially serious disease. But the epidemiology of SJS in China is not well defined. Read More

    [Factors associated with the severity of acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis in sub-Saharan Africa].
    Ann Dermatol Venereol 2018 Feb 24. Epub 2018 Feb 24.
    Service de dermatologie et IST, CHU de Sylvanus Olympio, université de Lomé, BP 30785, Lomé, Togo.
    Aim: The purpose of this study was to identify risk factors associated with the severity of acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in sub-Saharan Africa.

    Patients And Method: A retrospective study was carried out at the dermatology department in collaboration with the ophthalmology department for SJS/TEN patients between January 2000 and December 2016 in Lomé (Togo). The severity of acute ocular involvement was evaluated using the Power classification, and the drug eruption score was assessed using de Bastuji-Garin classification. Read More

    Risks associated with lamotrigine prescription: a review and personal observations.
    Australas Psychiatry 2018 Feb 1:1039856218760733. Epub 2018 Feb 1.
    Scientia Professor of Psychiatry, University of New South Wales, Sydney, NSW, and; Professorial Fellow, Black Dog Institute, Randwick, NSW, Australia.
    Objectives: To detail some serious lamotrigine side effects and their management, and raise awareness about the possible lack of quality control of some brands of lamotrigine.

    Methods: A literature review is provided and some personal observations added.

    Results: While most psychiatrists are aware of the risks of Stevens-Johnson syndrome (SJS), awareness of two other serious side effects - toxic epidermal necrosis (TEN) and drug-related eosinophilia and systemic symptoms (DRESS) - is seemingly lower. Read More

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