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    6077 results match your criteria Toxic Epidermal Necrolysis

    1 OF 122

    Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
    Pharmacoepidemiol Drug Saf 2017 Jun 27. Epub 2017 Jun 27.
    Units of Pediatrics, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
    Purpose: H1-antihistamines are commonly used in infants and children for the relief of histamine-mediated symptoms in a variety of conditions. Little is known about their safety profile in these patients. We performed a comparative analysis of the safety profiles of H1-antihistamines using data from the WHO database (VigiBase). Read More

    The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation.
    Allergol Int 2017 Jun 22. Epub 2017 Jun 22.
    Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan. Electronic address:
    Background: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. Read More

    Inhibitor of Apoptosis Proteins (Iaps) Limit Ripk1 Mediated Skin Inflammation.
    J Invest Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:
    Inhibitor of Apoptosis Proteins (IAPs) are critical regulators of cell death and survival pathways. Mice lacking cellular IAP (cIAP) 1 and either cIAP2 or X-linked IAP (XIAP) die in utero, and myeloid lineage-specific deletion of all IAPs causes sterile inflammation, but their role in the skin is unknown. We generated epidermal-specific IAPs deficient mice and found that combined genetic deletion of cIAP1 in keratinocytes and ubiquitous cIAP2 deletion (cIap1(EKO/EKO). Read More

    Things that could be Mycoplasma pneumoniae.
    J Infect 2017 Jun;74 Suppl 1:S95-S100
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Immunology and Rheumatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address:
    M. pneumoniae infection gives rise to a wide variety of manifestations. The pathogenesis of secondary manifestations is not always known. Read More

    Ciclosporin Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches.
    J Invest Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Clinical Pharmacology Unit, Príncipe de Asturias University Hospital, Department of Biomedical Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain. Electronic address:
    Several immunomodulatory agents are used in the treatment of Epidermal Necrolysis (EN), but evidence of their efficacy is limited. The Autonomous Community of Madrid has two reference Burn Units (BUs) to which all patients with EN are referred to. One BU has mostly used ciclosporin (CsA), while the other has used non-CsA therapies (mainly high-dose intravenous immunoglobulin). Read More

    A pilot study comparing histological and immunophenotypic patterns in stage 4 skin graft versus host disease from toxic epidermal necrolysis.
    J Cutan Pathol 2017 Jun 19. Epub 2017 Jun 19.
    Harvard Medical School, Boston, Massachusetts.
    Since the inception of bone marrow transplantation, clinicians have sought to distinguish stage 4 skin graft versus host disease (GVHD) from toxic epidermal necrolysis (TEN).(1-3) In certain contexts, it can be difficult to discern among these two entities, both clinically and histologically. However, the distinction is critical because both diseases can be life-threatening and their respective management and prognosis differ. Read More

    Letter to the Editor concerning the article "Long term complications of Stevens-Johnson syndrome/Toxic epidermal necrolysis: The spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multi-disciplinary follow up.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Sunnybrook Health Sciences Centre - Division of Dermatology, Department of Medicine, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada.
    We read with great interest, the review paper by Lee et al. on the long term complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. We would like to congratulate the authors on this important and excellent overview. Read More

    Association between the HLA-B alleles and carbamazepine-induced SJS/TEN: A meta-analysis.
    Epilepsy Res 2017 Jun 3;135:19-28. Epub 2017 Jun 3.
    Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
    Purpose: From our current understanding, the association between the human leukocyte antigen (HLA), HLA-B*1502, and carbamazepine(CBZ)-induced Stevens-Jonson syndrome and toxic epidermal necrolysis (SJS/TEN) in the Asian population is quite clear. However the relationship between other HLA-B alleles and CBZ-induced severe cutaneous adverse drug reactions (SCADRs) remains unclear. We aimed to identify other non-HLA-B*1502 alleles in patients with CBZ-induced SCADRs through a meta-analysis. Read More

    Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature.
    Case Rep Dermatol 2017 May-Aug;9(2):1-7. Epub 2017 May 8.
    Department of Dermatology and Venereology, Erasme Hospital, ULB, Brussels, Belgium.
    Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Read More

    T-cell activation in two cases of Stevens-Johnson syndrome after receiving amoxicillin-clavulanic acid.
    Pediatr Allergy Immunol 2017 Jun 9. Epub 2017 Jun 9.
    Allergy Unit, Department of Pediatric Medicine, Anna Meyer Children's University Hospital, Florence, Italy.
    Stevens-Johnson syndrome (SJS) is a rare life-threatening condition attributed almost exclusively to drug exposure (1). The main etiologic factor for SJS is treatment with drugs, primarily sulfonamides and anticonvulsants, followed by penicillins and non-steroidal anti-inflammatory drugs (1). Among penicillins, amoxicillin/clavulanic acid (AMX/CLV), despite generally being a well-tolerated antimicrobial, has been reported as a risk factor for SJS in adults and children in several publications (2, 3). Read More

    Graft versus host disease: what should the oculoplastic surgeon know?
    Curr Opin Ophthalmol 2017 Jun 8. Epub 2017 Jun 8.
    University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: To provide a concise review of the oculoplastic manifestations of ocular graft versus host disease (GVHD), and to discuss their management.

    Recent Findings: Ocular GVHD occurs as a common immune-mediated complication of hematopoietic stem cell transplantation that presents as a Stevens-Johnson-like syndrome in the acute phase or a Sjögren-like syndrome in the chronic phase. Cicatricial conjunctivitis may be underreported in ocular GVHD. Read More

    Tailoring of recommendations to reduce serious cutaneous adverse drug reactions: a pharmacogenomics approach.
    Pharmacogenomics 2017 Jun 8. Epub 2017 Jun 8.
    Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way, 11-03, Helios, Singapore 138667, Singapore.
    The Health Sciences Authority launched a pharmacogenetics initiative in 2008 to facilitate evaluation of pharmacogenetics associations pertinent for Chinese, Malays and Indians in Singapore. The aim was to reduce the incidence and unpredictability of serious adverse drug reactions, with a focus on serious skin adverse drug reactions. This paper describes the gathering of evidence and weighing of factors that led to different genotyping recommendations for HLA-B*15:02 with carbamazepine and HLA-B*58:01 with allopurinol, despite both having strong genetic associations. Read More

    Oxcarbazepine-induced Stevens-Johnson syndrome: a pediatric case report.
    Oxf Med Case Reports 2017 Jun 1;2017(6):omx028. Epub 2017 Jun 1.
    Department of Pediatric Allergy and Immunology, Trakya University Medical School, Edirne, Turkey.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are two rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions and mucous membrane erosions. Anti-epileptic drugs are highly suspected to be the causative agents. Although carbamazepine (CBZ) is the most associated anti-epileptic drug, oxcarbazepine (OXC), which is a monohydrated derivative of CBZ, is proposed to be safer because of the different metabolism of the two drugs. Read More

    Aprepitant for refractory nivolumab-induced pruritus.
    Lung Cancer 2017 Jul 27;109:58-61. Epub 2017 Apr 27.
    Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.
    Although substantial progress has been made in the treatment of non-small-cell lung cancer (NSCLC) patients with immune checkpoint inhibitors (ICIs), severe immune-related adverse events (irAEs) sometimes occur. Here, we report a case of severe refractory pruritus after Stevens-Johnson syndrome (SJS) in a patient with NSCLC treated with nivolumab. The patient was a 76-year-old Japanese woman with advanced NSCLC treated with nivolumab. Read More

    Life-threatening Skin Disorders Treated in the Burn Center: Impact of Health care-associated Infections on Length of Stay, Survival, and Hospital Charges.
    Clin Plast Surg 2017 Jul 26;44(3):597-602. Epub 2017 Apr 26.
    Department of Surgery, University of North Carolina School of Medicine, 7038 Burnett-Womack, Campus Box 7195, Chapel Hill, NC 27599, USA. Electronic address:
    This article reviews a single burn center experience with life-threatening skin disorders, over a 10-year period. It explores the incidence of health care-associated infections and the impact on length of stay, hospital charges, and mortality. Read More

    Burn Center Care of Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Clin Plast Surg 2017 Jul;44(3):583-595
    Department of Surgery, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Room D712, 1075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address:
    Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, life-threatening, cutaneous drug reactions. Medications are the most common cause, although an infection may be responsible. A link between genetics and certain medications has been established. Read More

    HLA-A*31: 01 and HLA-B*15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.
    Pharmacogenet Genomics 2017 Jul;27(7):275-278
    aDepartment of Medicine, Division of Neurology bDepartment of Genetics and Molecular Biology Programme, Institute of Biological Sciences, Faculty of Science cDepartment of Medicine, Division of Dermatology, Faculty of Medicine, University of Malaya, Kuala Lumpur dDepartment of Dermatology, Hospital Sultanah Bahiyah, Alor Setar, Kedah eSchool of Pharmacy, Monash University, Selangor, Malaysia.
    The majority of the carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis CBZ-SJS/TEN are associated with HLA-B*15:02 in Asian populations where this allele is common. In contrast, the association with HLA-A*31:01 is only reported in Japanese and Europeans. This study aimed to further investigate the association with HLA-A*31:01 besides HLA-B*15:02 in a multiethnic Malaysian population. Read More

    Mucositis Secondary to Chlamydia pneumoniae Infection: Expanding the Mycoplasma pneumoniae-Induced Rash and Mucositis Concept.
    Pediatr Dermatol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Dermatology, La Paz Hospital, Madrid, Spain.
    The term Mycoplasma pneumoniae-induced rash and mucositis (MIRM) was recently proposed to identify the mucocutaneous condition secondary to M. pneumoniae infection that had historically been regarded among the more confusing pathologies of erythema multiforme and Stevens-Johnson syndrome. Based on a number of previous reports, these syndromes require differentiation since they have different prognoses and specific treatment requirements. Read More

    CYP2C19*2 status in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.
    Pharmgenomics Pers Med 2017 17;10:183-186. Epub 2017 May 17.
    Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX.
    Purpose: Genetic polymorphisms have been linked to an increased predisposition to developing certain diseases. For example, patients of Han-Chinese descent carrying the HLA-B*1502 allele are at an increased risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) if given carbamazepine. Given the complexity of in vivo drug metabolism, it is plausible that the activity of enzyme systems unrelated to specific drug metabolism may be important. Read More

    Common allergies do not influence the prevalence of cutaneous hypersensitivity reactions to antiepileptic drugs.
    Epilepsy Res 2017 May 17;135:9-13. Epub 2017 May 17.
    Dept. of Neurology, Jagiellonian University Medical College, Krakow, Poland.
    Objective: The aim of the study was to establish whether the presence of common allergies increases the risk of drug-related hypersensitivity reactions among patients with epilepsy treated with antiepileptic drugs (AEDs).

    Methods: We studied 753 patients with epilepsy seen in tertiary outpatient epilepsy clinic. We obtained data related to epilepsy type, past and ongoing treatment with AEDs, occurrence of maculopapular exanthema or more serious cutaneous adverse reactions (Stevens-Johnson syndrome - SJS) and their characteristics. Read More

    Incidence and triggers of Stevens-Johnson syndrome and toxic epidermal necrolysis in a large cancer patient cohort.
    J Invest Dermatol 2017 May 23. Epub 2017 May 23.
    Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612; DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612. Electronic address:

    A cross-sectional comparative study on chronic ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series.
    Int Ophthalmol 2017 May 25. Epub 2017 May 25.
    Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong.
    Purpose: To compare the chronic ocular manifestations in Stevens-Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort.

    Methods: All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Read More

    Efficacy and Adverse Events of Oral Isotretinoin for Acne: A Systematic Review.
    Br J Dermatol 2017 May 19. Epub 2017 May 19.
    Dept. of Community Health Sciences, Cumming School of Medicine, University of Calgary.
    Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Read More

    The effect of comorbidities on overall mortality in Stevens- Johnson Syndrome: an analysis of the Nationwide Inpatient Sample.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Yale School of Medicine Department of Dermatology, New Haven, Connecticut.
    Background: Stevens Johnson Syndrome (SJS) is a life threatening skin condition with an overall mortality rate of 5%. Although the causes and pathology of the disease have been well studied, the factors that significantly contribute to mortality remain unclear.

    Objective: To determine relevant risk factors that increase the likelihood of inpatient mortality after diagnosis of SJS. Read More

    Negative wound pressure therapy is safe and useful in pediatric burn patients.
    Int J Burns Trauma 2017 15;7(2):12-16. Epub 2017 Apr 15.
    Shriners Hospital for ChildrenBoston, MA, America.
    Introduction: Negative Pressure Wound Therapy (NPWT) has proven to be a powerful tool in facilitating healing of difficult wounds of a variety of etiologies. The pediatric experience with NPWT has been limited due to concerns about vascular compression and pain associated with treatment.

    Method: A retrospective review was performed to evaluate the therapeutic effect of NPWT on children with difficult wounds due to burns or soft-tissue trauma. Read More

    The use of Biobrane(®) for wound coverage in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Burns 2017 May 16. Epub 2017 May 16.
    Ross Tilley Burn Centre, Toronto, Canada. Electronic address:
    Introduction: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN.

    Methods: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted. Read More

    Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study.
    Eur J Dermatol 2017 May 19. Epub 2017 May 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. Read More

    Purpura fulminans mimicking toxic epidermal necrolysis - additional value of 16S rRNA sequencing and skin biopsy.
    Neth J Med 2017 May;75(4):165-168
    Department of Intensive Care medicine, Jeroen Bosch Hospital, Den Bosch, the Netherlands.
    Both purpura fulminans and toxic epidermal necrolysis (TEN) are rare and life-threatening disorders with a high mortality. We present a case of suspected rapidly progressive, severe pneumococcal sepsis-induced purpura fulminans complicated by multiple organ failure, severe epidermolysis and cutaneous necrosis. We show the diagnostic challenge to differentiate between purpura fulminans and TEN, as the extensive epidermolysis in purpura fulminans may mimic TEN and we highlight the additional value of repeated skin biopsies and 16S rRNA gene sequencing. Read More

    Delayed Stevens-Johnson Syndrome Secondary to the Use of Lamotrigine in Bipolar Mood Disorder.
    Indian J Psychol Med 2017 Mar-Apr;39(2):209-212
    Department of Internal Medicine Possible Health, Achham, Nepal.
    Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. Read More

    Risk factors of allopurinol-induced severe cutaneous adverse reactions in a Thai population.
    Pharmacogenet Genomics 2017 Jul;27(7):255-263
    aDepartment of Pharmacology bPharmacy Unit cDepartment of Medicine, Faculty of Medicine dResearch and Diagnostic Center for Emerging Infectious Diseases eResearch Center in Back, Neck Other Joint Pain and Human Performance fSleep Apnea Research Group gFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen hSchool of Pharmaceutical Sciences, University of Phayao, Phayao iPharmacy Unit, Udon Thani Hospital, Udon Thani jDepartment of Pathology, Division of Pharmacogenomics and Personalized Medicine kLaboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center lDivision of Allergy Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok mDepartment of Pharmacy, Phrae Hospital, Phrae nCenter of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand oSchool of Pharmacy pHealth and Well-being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Malaysia qSchool of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.
    Background: Allopurinol is one of the most common causes of severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). This study identified the risk factors associated with the development of allopurinol-induced SCARs in a Thai population.

    Patients And Methods: Eighty-six allopurinol-induced SCARs (i. Read More

    Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim-sulfamethoxazole.
    CEN Case Rep 2016 Nov 7;5(2):188-191. Epub 2016 Jun 7.
    Division of Nephrology, Department of Medicine, St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, MA, 02135, USA.
    Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, D-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim-sulfamethoxazole complicated by the development of the Stevens-Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies. We review the existing literature on the potential association between sulfonamides and hypersensitivity polyangiitis. Read More

    Score of Toxic Epidermal Necrosis Predicts the Outcomes of Pediatric Epidermal Necrolysis.
    Pediatr Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    Background/objectives: Epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) includes immune-mediated, life-threatening inflammatory blistering disorders that can affect children. The Score of Toxic Epidermal Necrosis (SCORTEN) tool has accurately predicted the outcome of these disorders in adults but has not been tested in children.

    Methods: We performed a retrospective chart review to compare the accuracy of the adult SCORTEN tool with that of two modifications tailored to children in predicting disease outcome. Read More

    Methotrexate-induced epidermal necrosis: A case series of 24 patients.
    J Am Acad Dermatol 2017 May 10. Epub 2017 May 10.
    Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: Methotrexate-induced epidermal necrosis (MEN) is a rare but life-threatening cutaneous reaction that mimics Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

    Objectives: To investigate the clinicopathology, risk factors, and prognostic factors of MEN.

    Methods: We enrolled 24 patients with MEN and 150 controls and analyzed the demographics, pathology, and plasma concentrations of methotrexate (MTX). Read More

    Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study.
    BMC Ophthalmol 2017 May 12;17(1):65. Epub 2017 May 12.
    Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pok Fu Lam, Hong Kong.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN.

    Methods: The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared. Read More

    Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation.
    Pediatr Transplant 2017 May 12. Epub 2017 May 12.
    Department of Pediatrics, Oita University Faculty of Medicine, Oita University, Oita, Japan.
    TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Read More

    Eruptive melanocytic nevi during azathioprine therapy for antisynthetase syndrome.
    Cutis 2017 Apr;99(4):268-270
    Department of Dermatology, University of Maryland Medical Center, Baltimore, USA.
    Eruptive melanocytic nevi (EMN) are rare multiple benign melanocytic nevi that develop within a few months. The phenomenon has been associated with a variety of dermatologic and systemic conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, Addison disease, human immunodeficiency virus infection, and internal malignancy, among others. It also is commonly attributed to medications, particularly immunosuppressive and chemotherapeutic agents. Read More

    Stevens-Johnson syndrome/toxic epidermal necrolysis caused by cefadroxil in a cat.
    JFMS Open Rep 2016 Jan-Jun;2(1):2055116916653616. Epub 2016 Jun 6.
    Servizi Dermatologici Veterinari, Legnano, Milan, Italy.
    Case Summary: A 5-year-old, spayed female, indoor-only domestic shorthair cat was referred with an acute history of multifocal cutaneous and mucocutaneous erosive-ulcerative lesions and skin detachment. The lesions occurred on the seventh day of therapy with cefadroxil. Erosive-ulcerative and occasionally crusted lesions were apparent on the medial and lateral canthus of both eyes, ventral neck, abdomen, perivulvar region, periungual skin and medial aspect of the front and hindlimbs. Read More

    Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Treatment With a Biologic: A Case Report.
    Perm J 2017 ;21
    Attending Physician in Emergency Medicine at the Santa Clara Medical Center in CA.
    Introduction: One of the most dangerous dermatologic emergencies is Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN). Although a rare disease, it can often lead to significant mortality.

    Case Presentation: In this case report, we present a 77-year-old man who developed a sloughing rash that was secondary to a nonsteroidal anti-inflammatory drug. Read More

    Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice.
    J Allergy Clin Immunol Pract 2017 May - Jun;5(3):547-563
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn; Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia. Electronic address:
    Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an uncommon, potentially life-threatening, and challenging subgroup of IM-ADRs with diverse clinical phenotypes, mechanisms, and offending drugs. T-cell-mediated immunopathology is central to these severe delayed reactions, but effector cells and cytokines differ by clinical phenotype. Read More

    Ivermectin induced Steven-Johnsons syndrome: case report.
    BMC Res Notes 2017 May 8;10(1):179. Epub 2017 May 8.
    Presbyterian General Hospital Acha-Tugi, Acha, Cameroon.
    Background: Stevens-Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit. A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign. Read More

    HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.
    Neurology 2017 Jun 5;88(23):2183-2191. Epub 2017 May 5.
    Author affiliations are provided at the end of the article.
    Objective: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions.

    Methods: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Read More

    Severe cutaneous adverse reactions to drugs.
    Lancet 2017 May 2. Epub 2017 May 2.
    Department of Dermatology, Hôpital Henri-Mondor, AP-HP, Créteil, France; Centre de Référence des Dermatoses Bulleuses Toxiques, Créteil, France; EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val-de-Marne, Créteil, France; French Satellite of the Cochrane Skin Group, Créteil, France; INSERM, Centre d'Investigation Clinique 1430, Créteil, France.
    During the past decade, major advances have been made in the accurate diagnosis of severe cutaneous adverse reactions (SCARs) to drugs, management of their manifestations, and identification of their pathogenetic mechanisms and at-risk populations. Early recognition and diagnosis of SCARs are key in the identification of culprit drugs. SCARS are potentially life threatening, and associated with various clinical patterns and morbidity during the acute stage of Stevens-Johnson syndrome and toxic epidermal necrolysis, drug reactions with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. Read More

    Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription.
    Case Rep Dent 2017 3;2017:4201357. Epub 2017 Apr 3.
    Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, UKM and UKM Medical Centre, Kuala Lumpur, Malaysia.
    Failure to screen susceptible individuals for human leucocyte allele B∗1502 leads to the onset of Stevens-Johnson syndrome (SJS). We report a case of a 27-year-old Malay female who was treated with carbamazepine following the diagnosis of trigeminal neuralgia without a genetic screening. She was prescribed 150 mg of carbamazepine initially and the dose was increased to 300 mg following the initial dose. Read More

    Retrospective Analysis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in 88 Chinese Patients.
    Chin Med J (Engl) 2017 May;130(9):1062-1068
    Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
    Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases with high mortality rates. This study was designed to analyze the pathogenic factors, clinical manifestations, complications, treatment, and prognosis of SJS/TEN and to explore the differences between surviving and deceased patients.

    Methods: SJS/TEN patients admitted to Beijing Friendship Hospital from January 2006 to December 2015 were included in the study. Read More

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