Surgery 2021 Apr 21. Epub 2021 Apr 21.
ASPIRES (Antimicrobial Stewardship Programme), Medicine Quality and Safety, Vancouver Coastal Health, Vancouver, BC, Canada; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada; Pharmaceutical Sciences, Vancouver General Hospital, Vancouver Coastal Health, Vancouver, BC, Canada; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada. Electronic address:
Background: Cefazolin surgical prophylaxis is associated with better patient outcomes; however, its use in penicillin-allergic patients is controversial. We evaluated the safety of cefazolin as surgical prophylaxis in penicillin-allergic patients, including those with anaphylaxis histories.
Methods: We conducted a pre and postintervention quality improvement evaluation of an institution-wide policy change at a tertiary-care hospital, before (October 2017-January 2018), during (February 2018-September 2018), and after (October 2018-October 2019) transition to routine cefazolin prophylaxis for penicillin-allergic patients, including those with anaphylaxis histories but excluding severe delayed reactions (eg, Stevens-Johnson syndrome). Read More