233,911 results match your criteria Toxic Anterior Segment Syndrome


Influences of coal mines, metallurgical plants, urbanization and lithology on the elemental composition of street dust.

Authors:
Gorazd Žibret

Environ Geochem Health 2018 Dec 15. Epub 2018 Dec 15.

Geological Survey of Slovenia, Dimičeva ulica 14, 1000, Ljubljana, Slovenia.

Street dust (SD) acts as a sink and a source of atmospheric particulate matter, which is especially significant in urban environments. World studies of natural and anthropogenic impacts on the elemental composition of SD are generally limited to specific areas or case studies. The objectives of this study are to determine the impacts of different anthropogenic atmospheric dust emitters and natural factors on the chemical composition of SD, and to define sources of variance in elemental composition of SD, temporal variations and geochemical associations of elements on large number of samples, collected in different time periods, anthropogenic environments and geological settings. Read More

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December 2018

N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.

Bioorg Chem 2018 Dec 4;84:418-433. Epub 2018 Dec 4.

School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland. Electronic address:

1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. Read More

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December 2018

Bioaccumulation and morphological traits in a multi-generation test with two Daphnia species exposed to lead.

Chemosphere 2018 Dec 7;219:636-644. Epub 2018 Dec 7.

Department of Biology & CESAM, University of Aveiro, 3810-193, Portugal.

Anthropic pressure negatively affects natural environments. Lead (Pb) is a non-essential highly toxic metal that is present in aquatic ecosystems. Two daphnid species from two different latitudes, the temperate Daphnia magna and the tropical Daphnia similis were used as test-organisms to evaluate a long-term Pb exposure. Read More

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December 2018

A review of recent strategies for acid mine drainage prevention and mine tailings recycling.

Chemosphere 2018 Nov 28;219:588-606. Epub 2018 Nov 28.

Division of Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University, Japan.

Acid mine/rock drainage (AMD/ARD), effluents with low pH and high concentrations of hazardous and toxic elements generated when sulfide-rich wastes are exposed to the environment, is considered as a serious environmental problem encountered by the mining and mineral processing industries around the world. Remediation options like neutralization, adsorption, ion exchange, membrane technology, biological mediation, and electrochemical approach have been developed to reduce the negative environmental impacts of AMD on ecological systems and human health. However, these techniques require the continuous supply of chemicals and energy, expensive maintenance and labor cost, and long-term monitoring of affected ecosystems until AMD generation stops. Read More

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November 2018

Response of the biomining Acidithiobacillus ferrooxidans to high cadmium concentrations.

J Proteomics 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Molecular Microbiology and Biotechnology, Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile. Electronic address:

Cadmium is a heavy metal present in contaminated soils. It has no biological role but when entering cells generates DNA damage, overexpression of stress response proteins and misfolded proteins, amongst other deleterious effects. Acidithiobacillus ferrooxidans is an acidophilic bacterium resisting high concentrations of heavy metals such as cadmium. Read More

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December 2018

Phytotoxicity reduction of the mercury chloride effect by natural products from Eugenia jambolana Lam.: A new strategy against the toxic metal pollution.

Ecotoxicol Environ Saf 2018 Dec 13;170:461-467. Epub 2018 Dec 13.

Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, 63105-000 Crato, CE, Brazil. Electronic address:

The objective of this work was to evaluate the antioxidant, metal chelating and cytoprotective activity of the Eugenia jambolana Lam. extract, as well as of its flavonoid and tannic fractions, against the action of Mercury Chloride (HgCl). Flavonoids were quantified and an LC-MS chromatographic analysis was performed to identify secondary metabolites. Read More

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December 2018

Biodegradation of Cibacron Blue 3GA by insolubilized laccase and identification of enzymatic byproduct using MALDI-ToF-MS: Toxicity assessment studies by Daphnia magna and Chlorella vulgaris.

Ecotoxicol Environ Saf 2018 Dec 13;170:453-460. Epub 2018 Dec 13.

Biochemical Processing and Biomaterial Research Laboratory, Gazi University, 06500 Teknikokullar, Ankara, Turkey.

The presented paper describes a detailed study on the use of immobilized laccase for effective degradation of Cibacron Blue 3GA dye. The amount of laccase loading on the cyclic carbonate groups containing poly(hydroxyethyl methacrylate-co-vinylene carbonate), p(HEMA-co-VC), microbeads was 27.8 mg g, and the retained immobilized enzyme activity was 73% compared to free enzyme. Read More

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December 2018

Frequency of superantigen encoding genes of Staphylococcus aureus isolates collected from multiple sclerosis (MS) patients and nasal carriers.

Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system.

Objectives: In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers.

Methods: Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Read More

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December 2018

Enzymatic strategies for (near) clinical development of antibody-drug conjugates.

Drug Discov Today Technol 2018 Dec 11;30:3-10. Epub 2018 Oct 11.

Synaffix BV, Kloosterstraat 9, 5349 AB, Oss, The Netherlands; Wageningen University and Research, Laboratory of Organic Chemistry, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. Electronic address:

Target-specific killing of tumor cells with antibody-drug conjugates (ADCs) is an elegant concept in the continued fight against cancer. However, despite more than 20 years of clinical development, only four ADC have reached market approval, while at least 50 clinical programs were terminated early. The high attrition rate of ADCs may, at least in part, be attributed to heterogeneity and instability of conventional technologies. Read More

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December 2018

Insect toxins - selective pharmacological tools and drug/chemical leads.

Curr Opin Insect Sci 2018 Dec 9;30:93-98. Epub 2018 Oct 9.

Centre for Respiratory Biology, UCL Respiratory, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK. Electronic address:

Insect toxins comprise a diverse array of chemicals ranging from small molecules, polyamines and peptide toxins. Many target nervous system and neuromuscular ion channels and so rapidly affect the behaviour of animals to which the toxin is applied or injected. Other modes of action have also been identified. Read More

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December 2018

Synthesis and characterization of a biodegradable Cellulose acetate-montmorillonite composite for effective adsorption of Eosin Y.

Carbohydr Polym 2019 Feb 15;206:863-872. Epub 2018 Nov 15.

Natural Product Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India. Electronic address:

Cellulose extracted from the rhizomes of Alpinia nigra was utilized in the synthesis of cellulose acetate. Furthermore, the cellulose acetate reacted with organophillic montmorillonite to form a composite. All the products including cellulose, cellulose acetate and the composite were characterized with the help of standard analytical techniques. Read More

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February 2019

Synthesis of pyridine-free xylan sulfates.

Carbohydr Polym 2019 Feb 2;206:65-69. Epub 2018 Nov 2.

Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Center of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743 Jena, Germany. Electronic address:

The usual sulfation of polysaccharides applying chlorosulfuric acid and pyridine may form products containing pyridine-based impurities, which may yield toxic side effects. The synthesis of pyridine-free polysaccharide sulfates could be realized simply by using xylan that was treated with a reducing agent (NaBH) prior to the sulfation reaction. The reduced xylan possess same reactivity compared to untreated xylan. Read More

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February 2019

Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.

Carbohydr Polym 2019 Feb 10;206:539-547. Epub 2018 Nov 10.

Laboratory of Enzyme Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences, Vladivostok, Russian Federation. Electronic address:

The laminarans are neutral water-soluble β-D-glucans of brown algae possessing potent immunomodulating, radioprotective, and anticancer activities. The aim of the present study was to investigate in vitro anticancer, radioprotective, and radiosensitizing activities of laminaran from brown alga Dictyota dichotoma and its sulfated derivative. The native and sulfated laminarans by themselves at non-toxic doses possessed significant anticancer activity against melanoma cells. Read More

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February 2019

Pineapple crown delignification using low-cost ionic liquid based on ethanolamine and organic acids.

Carbohydr Polym 2019 Feb 31;206:302-308. Epub 2018 Oct 31.

UNIT, Universidade Tiradentes, Av. Murilo Dantas, 300, Farolândia, 49032-490, Aracaju, SE, Brazil; ITP, Instituto de Tecnologia e Pesquisa, Av. Murilo Dantas, 300-Prédio do ITP, Farolândia, 49032-490, Aracaju, SE, Brazil. Electronic address:

Pineapple fibre was treated with protic ionic liquids (PILs) and the effects on the structure, composition, and properties of the fibres were evaluated. Treatment with PILs efficiently exposed the fibre surface, as confirmed by scanning electron microscopy. The chemical composition analysis revealed reductions in the lignin and hemicellulose contents in the treated fibres, promoting exposure of cellulose. Read More

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February 2019

Eco-friendly modification of a regenerated cellulose based film by silicon, carbon and N-doped carbon quantum dots.

Carbohydr Polym 2019 Feb 29;206:238-244. Epub 2018 Oct 29.

Grupo de Caracterización Electrocinética en Membranas e Interfases, Dpto. Física Aplicada I, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain. Electronic address:

Modification of a regenerated cellulose thin film by inclusion of different non-toxic nanodots (silicon-dots (SiDs), carbon-dots (CDs)) or nitrogen-doped carbon dots (N-CDs)) by aqueous nanodots solution immersion was performed. Nanodots presence into the cellulosic structure was evidenced by confocal microscopy images at different depth and changes in film mechanical, electrical and optical parameters. Our results reveal that the inclusion of the different nanodots in the cellulosic support increases, indifferent percentages, the mechanical resistance and electrical conductivity of modified films, but they hardly affect light transmittance. Read More

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February 2019

Mucoadhesive guargum hydrogel inter-connected chitosan-g-polycaprolactone micelles for rifampicin delivery.

Carbohydr Polym 2019 Feb 29;206:1-10. Epub 2018 Oct 29.

Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625021, India. Electronic address:

Natural polymer guar gum has one of the highest viscosities in water solution and hence, these are significantly used in pharmaceutical applications. Guar gum inter-connected micelles as a new carrier has been developed for poor water soluble rifampicin drug. The hydrogel inter-connected micelle core was formulated as a hydrophilic inner and hydrophobic outer core by using guar gum/chitosan/polycaprolactone and the carrier interaction with rifampicin was confirmed by FT-IR. Read More

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February 2019

Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos.

Chemosphere 2018 Dec 8;219:557-566. Epub 2018 Dec 8.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China; Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China. Electronic address:

α-Bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is a common ingredient in many pharmaceuticals and personal care products (PPCPs). Despite being widely used, little is known about its toxic effects on organisms and aquatic environment. In this study, we investigated the developmental toxicity of α-Bisabolol, especially its effects on the cardiac development using zebrafish embryos as a model. Read More

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December 2018

Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development.

Chemosphere 2018 Dec 8;219:517-525. Epub 2018 Dec 8.

Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Hangzhou, 310021, Zhejiang, China. Electronic address:

Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0. Read More

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December 2018
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Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity.

Mult Scler Relat Disord 2018 Dec 5;28:34-43. Epub 2018 Dec 5.

Neuroimmunological Diseases Section (NDS), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5N248, 10 Center Drive, MSC1444, Bethesda, MD 20892, United States. Electronic address:

Background: Once multiple sclerosis (MS) reaches the progressive stage, immunomodulatory treatments have limited efficacy. This suggests that processes other than activation of innate immunity may at least partially underlie disability progression during late stages of MS. Pathology identified these alternative processes as aberrant activation of astrocytes and microglia, and subsequent degeneration of oligodendrocytes and neurons. Read More

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December 2018

Excess copper promotes photoinhibition and modulates the expression of antioxidant-related genes in Zostera muelleri.

Aquat Toxicol 2018 Dec 5;207:91-100. Epub 2018 Dec 5.

Climate Change Cluster, University of Technology Sydney, NSW, Australia.

Copper (Cu) is an essential micronutrient for plants and as such is vital to many metabolic processes. Nevertheless, when present at elevated concentrations, Cu can exert toxic effects on plants by disrupting protein functions and promoting oxidative stress. Due to their proximity to the urbanised estuaries, seagrasses are vulnerable to chemical contamination via industrial runoff, waste discharges and leachates. Read More

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December 2018
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Enhanced remedial effects for vitamin D and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia. Electronic address:

Background: Lead (Pb) is a toxic heavy metal and nephropathy is common with chronic exposure. Although vitamin D (VD) and calcium (Ca) showed promising protections, their co-administration was not previously investigated in Pb nephrotoxicity. This study measured the potential interactions and remedial effects of VD and/or Ca on established Pb nephropathy. Read More

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December 2018

Revival of a Potent Therapeutic Maytansinoid Agent using a Strategy that Combines Covalent Drug Conjugation with Sequential Nanoparticle Assembly.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China. Electronic address:

Maytansine and its related analogues are a class of highly potent anti-proliferation agents that have failed to be exploited as clinical drugs for human therapy due to unacceptable systemic toxicity. Here, we delineate a novel strategy that combines rational drug conjugation with subsequent nanoparticle assembly to systemically deliver this highly potent and toxic drug. To demonstrate this concept, we covalently coupled the thiolated maytansine derivative, the DM1 agent, to amphiphilic block co-polymers, polyethylene glycol (PEG)-block-polylactide (PLA), in varying molecular weights to generate two prodrug constructs (i. Read More

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December 2018
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Biogenic nanomaterials: Synthesis, characterization, growth mechanism, and biomedical applications.

J Microbiol Methods 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Jangan-gu, Suwon, Gyeonggido 16419, Republic of Korea. Electronic address:

The biosynthesis of nanomaterials is a huge and intensifying field of research due to their application in various areas, in particular the biomedical and pharmaceutical fields. In this review, we focused on the biosynthesis of both metallic and semiconductor nanomaterials and their application in biomedicine and pharmaceutics. In order to meet an exponentially increasing need for nanostructured materials, the biological route for the synthesis of nanomaterials will have to be explored, offering advantages over chemical and physical methods as a simpler, more cost effective, and environmentally friendly method, and for which there is no need to use high pressure and temperatures or toxic chemicals. Read More

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December 2018

Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision.

Life Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation, rheumatoid arthritis, lupus erythematosus, multiple sclerosis, neuroblastoma and other types of cancer. Dose-related cardiotoxicity is a limiting factor for its use. Read More

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December 2018
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Nucleus-targeted organoiridium-albumin conjugate for photoactivated cancer therapy.

Angew Chem Int Ed Engl 2018 Dec 15. Epub 2018 Dec 15.

University of Warwick, Chemistry, Gibbet Hill Road, CV4 7AL, Coventry, UNITED KINGDOM.

: A highly phosphorescent organoiridium-albumin conjugate (Ir1-HSA) was synthesized by reacting an organo-iridium complex (Ir1) containing a pendant maleimide with human serum albumin. The phosphorescence of the Ir1-HSA conjugate is much stronger than the parent iridium complex. Real-time cellular imaging shows that the conjugate mainly accumulates in the nucleus of cancer cells. Read More

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December 2018

The Drug Shortage Crisis in the United States: Impact on Cancer Pharmaceutical Safety.

Cancer Treat Res 2019 ;171:75-92

University of Colorado Denver, Denver, CO, USA.

Drug shortages pose a significant public health concern in the United States, and cancer drugs are among those most affected. Shortages present serious safety risks for patients and substantial burden on providers and the healthcare system. Multifaceted drivers of this complex problem include manufacturing disruptions, raw material shortages, regulatory issues, market dynamics, and limited financial incentives that reward quality and production of off-patent drugs. Read More

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January 2019

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

BASF SE, Experimental Toxicology and Ecology, Carl Bosch Straße 38, 67056, Ludwigshafen, Germany.

While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay concentrations may misrepresent potential in vivo effects and do not provide dose-response data which can be used for a risk assessment. We used reverse dosimetry to compare in vitro effect concentrations-to-in vivo doses causing toxic effects related to endocrine disruption. Ten compounds (acetaminophen, bisphenol A, caffeine, 17α-ethinylestradiol, fenarimol, flutamide, genistein, ketoconazole, methyltestosterone, and trenbolone) have been tested in the yeast estrogen screening (YES) or yeast androgen-screening (YAS) assays for estrogen and androgen receptor binding, as well as the H295R assay (OECD test guideline no. Read More

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December 2018

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides.

Sci Rep 2018 Dec 14;8(1):17850. Epub 2018 Dec 14.

Traditional Chinese Medicine College, Jilin Agricultural University, Changchun City, Jilin Province, 130118, China.

Asarum spp. are important medicinal plants that have the potential for use in treating various types of fevers. Aristolochic acid is one of the main toxic compounds present in these plants. Read More

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December 2018
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Essential oils sensory quality and their bioactivity against the mosquito Aedes albopictus.

Sci Rep 2018 Dec 14;8(1):17857. Epub 2018 Dec 14.

Department of Agriculture, Food and Environment - University of Pisa, Pisa, Italy.

Repellents are a main tool to prevent the outbreak of mosquito-borne diseases that represents a threat for millions of people worldwide. Plant-based products are very promising, low-toxic and eco-friendly alternative to synthetic repellents. Here, we performed an olfactory screening of the essential oils (EOs) of Artemisia verlotiorum Lamotte (Asteraceae), Lavandula dentata L. Read More

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December 2018
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Occurrence and diversity of cyanotoxins in Greek lakes.

Sci Rep 2018 Dec 14;8(1):17877. Epub 2018 Dec 14.

Institute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Grigoriou E' & Neapoleos 27, 15341, Athens, Greece.

Toxic cyanobacteria occur in Greek surface water bodies. However, studies on the occurrence of cyanotoxins (CTs) are often limited to mainly microcystins (MCs), with use of screening methods, such as ELISA, that are not conclusive of the chemical structure of the CT variants and can be subject to false positive results. A multi-lake survey in Greece (14 lakes) was conducted in water and biomass, targeted to a wide range of multi-class CTs including MCs, nodularin-R (NOD), cylindrospermopsin (CYN), anatoxin-a (ANA-a) and saxitoxins (STXs), using multi-class/variant LC-MS/MS analytical workflows, achieving sensitive detection, definitive identification and accurate quantitation. Read More

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December 2018

Fluorine-free water-in-ionomer electrolytes for sustainable lithium-ion batteries.

Nat Commun 2018 Dec 14;9(1):5320. Epub 2018 Dec 14.

Helmholtz Institute Münster - Forschungszentrum Jülich GmbH (IEK 12), Corrensstrasse 46, 48149 Münster, D-48149, Münster, Germany.

The continuously increasing number and size of lithium-based batteries developed for large-scale applications raise serious environmental concerns. Herein, we address the issues related to electrolyte toxicity and safety by proposing a "water-in-ionomer" type of electrolyte which replaces organic solvents by water and expensive and toxic fluorinated lithium salts by a non-fluorinated, inexpensive and non-toxic superabsorbing ionomer, lithium polyacrylate. Interestingly, the electrochemical stability window of this electrolyte is extended greatly, even for high water contents. Read More

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December 2018

Safety and Activity of Sorafenib in Addition to Vinflunine in Post-Platinum Metastatic Urothelial Carcinoma (Vinsor): Phase I Trial.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.

Lessons Learned: First trial to report safety and activity of the microtubule inhibitor vinflunine plus the tyrosine kinase inhibitor sorafenib in post-platinum metastatic urothelial cancer (mUC) patients.A recommended phase II dose was identified for the treatment combination of vinflunine plus sorafenib, with main adverse events including fatigue, febrile neutropenia, neutropenia, hypertension, and hyponatremia.An overall response rate of 41% to second-line vinflunine plus sorafenib treatment in patients with platinum-resistant mUC was confirmed. Read More

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December 2018

Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells.

Immunity 2018 Dec 4. Epub 2018 Dec 4.

Center for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

Salmonella enterica (Se) bacteria cause persistent intracellular infections while stimulating a robust interferon-γ-producing CD4 T (Th1) cell response. We addressed this paradox of concomitant infection and immunity by tracking fluorescent Se organisms in mice. Se bacteria persisted in nitric oxide synthase (iNOS)-producing resident and recruited macrophages while inducing genes related to protection from nitric oxide. Read More

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December 2018

Treatment of Wastewater Using Seaweed: A Review.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Sustainable Waste-To-Wealth, UTM-MPRC Institute for Oil & Gas, Resource Sustainability Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia.

Inadequately treated or untreated wastewater greatly contribute to the release of unwanted toxic contaminants into water bodies. Some of these contaminants are persistent and bioaccumulative, becoming a great concern as they are released into the environment. Despite the abundance of wastewater treatment technologies, the adsorption method overall has proven to be an excellent way to treat wastewater from multiple industry sources. Read More

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December 2018
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RAD-ical New Insights into RAD51 Regulation.

Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.

Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

The accurate repair of DNA is critical for genome stability and cancer prevention. DNA double-strand breaks are one of the most toxic lesions; however, they can be repaired using homologous recombination. Homologous recombination is a high-fidelity DNA repair pathway that uses a homologous template for repair. Read More

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December 2018

Nile Tilapia Derived TP4 Shows Broad Cytotoxicity Toward to Non-Small-Cell Lung Cancer Cells.

Mar Drugs 2018 Dec 13;16(12). Epub 2018 Dec 13.

Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Ilan 262, Taiwan.

Non-small cell lung cancer (NSCLC) is among the leading causes of human mortality due to a lack of effective treatments. Conventional chemotherapies affect healthy cells and cause multidrug resistance, while tumors may eventually develop resistance to less-toxic targeted therapies. Thus, the need to develop novel therapies for NSCLC is urgent. Read More

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December 2018

Influence of Liver Condition and Copper on Selective Parameters of Post-Mortem Dog Tissue Samples.

Animals (Basel) 2018 Dec 13;8(12). Epub 2018 Dec 13.

Nutrition Innovation, Hill's Pet Nutrition, Topeka, KS 66601, USA.

One of the liver functions is copper storage, which can be toxic when in excess. The objective of this retrospective study was to determine the relationship between hepatic copper and pathology conditions in stored samples from 55 post-mortem dogs (37 Beagles, 12 Labrador Retrievers, and 6 Labrador Mixes). The analyses evaluated data from blood chemistry and complete blood count (CBC) that were measured immediately before euthanasia, and liver biopsies which were harvested at necropsy and frozen at -80 °C. Read More

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December 2018

Evaluation of the Bioavailability and Translocation of Selected Heavy Metals by and L for a South African Power Utility Coal Fly Ash.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Environmental Remediation and Geopollution Group, Department of Geology, Faculty of Science, Ekiti State University, Ado Ekiti, Private Mail Bag 5363, Ado Ekiti 360001 Nigeria.

This study evaluated the physicochemical and mineralogical properties, mobile chemical species bioavailability and translocation in and L. plants of a South African coal-fired power utility. Coal-fly-ash (CFA) disposal is associated with various environmental and health risks, including air, soil, surface, and groundwater pollution due to the leaching of toxic heavy metals; these ends up in food webs affecting human health, while repeated inhalation causes bronchitis, silicosis, hair loss, and lung cancer. Read More

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December 2018
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Combined In Vitro Studies and in Silico Target Fishing for the Evaluation of the Biological Activities of and .

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

Servico de Biotecnologia Vegetal, Fundacao Ezequiel Dias (FUNED), Belo Horizonte 30510-010, MG, Brazil.

This paper reports the in silico prediction of biological activities of lignans from and combined with an in vitro bioassays. The extracts from the leaves, roots and rhizomes of both species were evaluated for their antibacterial, anticholinesterasic, antioxidant and cytotoxic activities. A group of 27 lignans was selected for biological activities prediction using the Active-IT system with 1987 ligand-based bioactivity models. Read More

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December 2018
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An overview of plant-based interventions to ameliorate arsenic toxicity.

Biomed Pharmacother 2019 Jan 5;109:838-852. Epub 2018 Nov 5.

Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), SASTRA Deemed-to-be University, Thanjavur, 613 401, India. Electronic address:

The industrial and technological advancements in the world have also contributed to the rapid deterioration in the environment quality through introduction of obnoxious pollutants that threaten to destroy the subtle balance in the ecosystem. The environment contaminants cause severe adverse effects to humans, flora and fauna that are mostly irreversible. Chief among these toxicants is arsenic, a metalloid, which is considered among the most dangerous environmental toxins that leads to various diseases which affect the quality of life even when present in small quantities. Read More

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January 2019

Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats.

Biomed Pharmacother 2019 Jan 3;109:2527-2538. Epub 2018 Dec 3.

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Egypt.

Mesoporous silica nanoparticles (MSNs) represent one of the most promising drug delivery systems. MSNs have attracted considerable attention in recent years both in industry and biomedicine due to their unique properties. Thus, evaluation of the toxic effects of MSNs is necessary before the biomedical and clinical applications. Read More

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January 2019

Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo.

Biomed Pharmacother 2019 Jan 30;109:2375-2386. Epub 2018 Nov 30.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Triptolide (TP) has an anti-proteinuric effect and is used for the treatment of podocytopathies. TP has also been shown to act directly on immortalized podocytes in culture to protect them from injury. In the present study, we examined the effect of TP on healthy podocytes both in vitro and in vivo to better understand the action of TP on podocytes. Read More

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January 2019

Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model.

Biomed Pharmacother 2019 Jan 28;109:2285-2292. Epub 2018 Nov 28.

Institute of Microbiology, University of Agriculture, Faisalabad, 38040, Pakistan.

Cinnamomum zeylanicum, a widely used spice and flavor, is used in the treatment and prevention of many diseases. In the current study, Balb/c mice were pretreated with cinnamon bark aqueous extract (200 mg/kg/day i.g. Read More

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January 2019

Metformin; an old antidiabetic drug with new potentials in bone disorders.

Biomed Pharmacother 2019 Jan 26;109:1593-1601. Epub 2018 Nov 26.

Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

The prevalence of diabetes mellitus especially type 2 diabetes mellitus is increasing all over the world. In addition to cardiomyopathy and nephropathy, diabetics are at higher risk of mortality and morbidity due to greater risk of bone fractures and skeletal abnormalities. Patients with diabetes mellitus have lower bone quality in comparison to their non-diabetic counterparts mainly because of hyperglycemia, toxic effects of advanced glycosylation end-products (AGEs) on bone tissue, and impaired bone microvascular system. Read More

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January 2019

Effects of nimodipine, vinpocetine and their combination on isoproterenol-induced myocardial infarction in rats.

Biomed Pharmacother 2019 Jan 12;109:1372-1380. Epub 2018 Nov 12.

Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi, 110062, India. Electronic address:

Background: Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Nimodipine is a calcium (Ca channel blocker as well as a PDE1 inhibitor and primarily used in subarachnoid haemorrhage (SAH) due to its blood-brain barrier crossing property. Nimodipine and vinpocetine inhibit the degradation of phosphodiester bond which increases cGMP and cAMP levels causing vasodilation. Read More

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January 2019
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Protective and reversal actions of a novel peptidomimetic against a pivotal toxin implicated in Alzheimer's disease.

Biomed Pharmacother 2019 Jan 6;109:1052-1061. Epub 2018 Nov 6.

Neuro-Bio Ltd, Culham Science Centre, Building F5, Abingdon, OX14 3DB, UK.

Despite the many attempts to understand the aetiology of Alzheimer's disease, the basic mechanisms accounting for the progressive cycle of neuronal loss are still unknown. Previous work has suggested that the pivotal molecule mediating neurodegeneration could be an independently acting peptide cleaved from acetylcholinesterase. This previously unidentified agent acts as a signalling molecule in selectively vulnerable groups of cells where erstwhile developmental mechanisms are activated inappropriately to have a toxic effect in the context of the mature brain. Read More

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January 2019

Functionality and cross-regulation of the four SprG/SprF type I toxin-antitoxin systems in Staphylococcus aureus.

Nucleic Acids Res 2018 Dec 15. Epub 2018 Dec 15.

Université de Rennes 1, Inserm, BRM (Bacterial Regulatory RNAs and Medicine) UMR_S 1230, 35000 Rennes, France.

Toxin-antitoxin (TA) systems are ubiquitous among bacteria, frequently expressed in multiple copies, and important for functions such as antibiotic resistance and persistence. Type I TA systems are composed of a stable toxic peptide whose expression is repressed by an unstable RNA antitoxin. Here, we investigated the functionalities, regulation, and possible cross-talk between three core genome copies of the pathogenicity island-encoded 'sprG1/sprF1' type I TA system in the human pathogen Staphylococcus aureus. Read More

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December 2018

Significant inhibition of photosynthesis and respiration in leaves of Cucumis sativus L. by oxybenzone, an active ingredient in sunscreen.

Chemosphere 2018 Dec 3;219:456-462. Epub 2018 Dec 3.

State Key Laboratory of Crop Biology, China; College of Life Sciences, Shandong Agricultural University, China. Electronic address:

Oxybenzone (OBZ), an active ingredient in most sunscreens, was recently shown to be toxic to humans, corals and other animals. This study is the first to demonstrate that OBZ can significantly inhibit photosynthesis and respiration in the leaves of a higher plant, cucumber. An OBZ suspension content as low as 0. Read More

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December 2018
3 Reads

High-performance carbon/MnO micromotors and their applications for pollutant removal.

Chemosphere 2018 Dec 7;219:427-435. Epub 2018 Dec 7.

Institute of Environmental Engineering, ETH Zurich, Schafmattstrasse 6, 8093, Zurich, Switzerland; Advanced Analytical Technologies Laboratory, EMPA, Überlandstrasse 129, 8600, Dübendorf, Switzerland. Electronic address:

The wide applications of particulate micromotors in practice, especially in the removal of environmental pollutants, have been limited by the low production yields and demand on high concentration of fuel such as HO. Carbon/MnO micromotors were made hydrothermally using different carbon allotropes including graphite, carbon nanotube (CNT), and graphene for treatment of methylene blue and toxic Ag ions. The obtained micromotors showed high speed of self-propulsion. Read More

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December 2018
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Nitrogen transformation during pyrolysis of oilfield sludge with high polymer content.

Chemosphere 2018 Nov 27;219:383-389. Epub 2018 Nov 27.

State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.

Oilfield sludge is recognized as a hazardous solid waste in China because of its considerable hydrocarbon content and other toxic components. In this study, the nitrogen transformation during pyrolysis of typical oil sludge samples produced in the Daqing oilfield (the largest oilfield in China), was experimentally investigated. X-ray photoelectron spectroscopy (XPS) and thermos gravimetric (TG) were used in laboratory-scale experiments and batch pyrolysis experiments were conducted at 200-800 °C in a tubular reactor to obtain quantitative information on the change of nitrogen conversion in the char, tar, and gas fractions. Read More

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November 2018
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