150 results match your criteria Toxic Anterior Segment Syndrome


Report of a cluster of cases of toxic anterior-segment syndrome after implantation of a specific intraocular lens model.

Am J Ophthalmol 2021 Apr 4. Epub 2021 Apr 4.

Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan.

Purpose: To report a cluster of cases of toxic anterior-segment syndrome (TASS) in eyes implanted with a specific foldable acrylic intraocular lens (IOL) model.

Design: Retrospective case series.

Methods: The medical records were reviewed for seven eyes of four patients diagnosed with TASS after cataract surgery at Shimane University and Matsue Red Cross Hospital between July and November 2020. Read More

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Severe Intraocular Inflammation following Hydrophilic Acrylic Phakic Intraocular Lens Implantation in A Case with Concealed History of COVID-19: A Case Report and Literature Review.

Ocul Immunol Inflamm 2021 Apr 1:1-4. Epub 2021 Apr 1.

Department of Ophthalmology, Faculty of Medicine, Pamukkale University, Kinikli, Turkey.

: To firstly present management of toxic anterior segment syndrome (TASS) and possible postoperative endophthalmitis (POE) after implantation of a new hydrophilic-acrylic posterior chamber (PC) phakic intraocular lens (pIOL) in a case with undeclared history of COVID-19. A 21-year-old male without known disease represented severe anterior chamber inflammation (hypopyon), poor vision and corneal edema without vitreous involvement (TASS) at 24-hours after PC-pIOL implantation for unilateral high myopia (amblyopic). Preoperative best-corrected visual acuity (BCVA) was 0. Read More

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Toxic Anterior Segment Syndrome with Intracameral Moxifloxacin: Case Report and Review of the Literature.

Case Rep Ophthalmol Med 2021 2;2021:5526097. Epub 2021 Mar 2.

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.

A case of severe anterior segment toxicity secondary to high-volume, undiluted intracameral moxifloxacin for endophthalmitis prophylaxis is reported. We examine the other reported cases of toxicity after intracameral moxifloxacin, as well as iris depigmentation and transillumination syndromes after oral and topical fluoroquinolone exposure. Additionally, we review the literature on safety, efficacy, and appropriate dosing of intracameral antibiotics with a focus on moxifloxacin. Read More

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Intracameral r-tPA for the management of severe fibrinous reactions in TASS after cataract surgery.

Eur J Ophthalmol 2021 Mar 15:11206721211002064. Epub 2021 Mar 15.

Ophthalmology Department, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: To describe the use of intracameral recombinant tissue plasminogen activator (r-tPA) in the treatment of severe fibrinous reactions in toxic anterior segment syndrome (TASS) after cataract surgery.

Methods: A case series of 59 eyes of 59 patients with severe fibrinous anterior chamber reaction following cataract surgery who received intracameral r-tPA (25 µg/0.1 ml). Read More

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Early Complications With Preloaded Descemet Membrane Endothelial Keratoplasty Are Not Dependent on Optisol-GS Washout or Trypan Blue Restaining.

Cornea 2020 Dec 16;Publish Ahead of Print. Epub 2020 Dec 16.

Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR; Department of Ophthalmology, Veterans Affairs Medical Center, Portland, OR; and Lions Vision Gift, Portland, OR.

Purpose: To describe the intraoperative and early postoperative complications using preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts with intraocular injection of the graft in Optisol-GS and omission of trypan blue restaining.

Methods: This is a retrospective case series of 132 consecutive eyes with Fuchs endothelial dystrophy or endothelial failure who underwent DMEK using preloaded donor tissue prepared as previously described. The graft was not restained with trypan blue by the surgeon, and Optisol-GS was injected with the graft into the eye instead of being rinsed from the injector. Read More

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December 2020

Postoperative Endophthalmitis and Toxic Anterior Segment Syndrome Prophylaxis: 2020 Update.

Ann Transl Med 2020 Nov;8(22):1548

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Improved surgical techniques have led to an increase in the number of outpatient ophthalmic procedures. In spite of decreased surgical times and overall improved outcomes, endophthalmitis remains one of the most severe complications of ophthalmic surgery. Although there are well known risk factors for postoperative endophthalmitis, some prophylaxis strategies remain controversial. Read More

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November 2020

Occlusion of AquaPORT Flow in a Case of Toxic Anterior Segment Syndrome Following Implantable Collamer Lens Surgery Causing Severe Pupillary Block.

J Refract Surg 2020 Dec;36(12):856-859

Purpose: To present a case where following Implantable Collamer Lens (ICL) implantation the patient developed toxic anterior segment syndrome (TASS) with a subsequent pupillary block as a consequence of the occlusion of the AquaPORT (STAAR Surgical) flow hole.

Methods: Case report and literature review.

Results: A V4c toric ICL (STAAR Surgical) was implanted in the left eye of a 32-year-old woman. Read More

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December 2020

Unilateral Toxic Anterior Segment Syndrome Resulting in Cataract and Urrets-Zavalia Syndrome after Sequential Uneventful Implantation of a Posterior Chamber Phakic Toric Intraocular Lens at Two Different Surgical Facilities: A Series of Unfortunate Events.

Case Rep Ophthalmol Med 2020 3;2020:1216578. Epub 2020 Nov 3.

Department of Clinical Research, Black Mammoth Surgical, Medellín, Colombia.

Background: Phakic Intraocular Lens (P-IOL) implantation is a safe, easy, predictable intervention designed to manage moderate to high refractive errors. Complications are relatively uncommon and include mainly cataract and intraocular pressure spikes. Toxic Anterior Segment Syndrome (TASS) is a rather unusual sterile anterior segment inflammation after uneventful intraocular surgery, extremely rarely reported after P-IOL implantation. Read More

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November 2020

Descemet Membrane Endothelial Keratoplasty in Toxic Anterior Segment Syndrome: A Case Series.

Cornea 2020 Oct 2. Epub 2020 Oct 2.

Department of Ophthalmology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.

Purpose: To evaluate the outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients with toxic anterior segment syndrome (TASS).

Methods: Thirteen eyes of 13 patients who underwent DMEK for endothelial decompensation secondary to TASS were retrospectively reviewed. A comprehensive ocular examination including best-corrected visual acuity (BCVA), slitlamp biomicroscopy, intraocular pressure measurement, fundus evaluation, and measurement of central corneal thickness were performed in all patients at preoperatively and postoperatively. Read More

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October 2020

The association between toxic anterior segment syndrome and intraocular pressure.

Graefes Arch Clin Exp Ophthalmol 2021 Feb 11;259(2):425-430. Epub 2020 Sep 11.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate the association between toxic anterior segment syndrome (TASS) and intraocular pressure (IOP).

Methods: This is a retrospective, controlled, single-site study. Patients who developed TASS following a clear corneal incision cataract surgery in Rabin Medical Center (Petah Tikva, Israel), between the years 2010-2018, were enrolled. Read More

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February 2021

Pure phaco: phacoemulsification without ophthalmic viscosurgical devices.

J Cataract Refract Surg 2020 02;46(2):174-178

From the Chandraprabha Eye Hospital, Jorhat, Assam, India.

The ophthalmic viscosurgical device (OVD) is an essential part of modern phacoemulsification surgery. Many times, OVDs are blamed for intraocular pressure spikes, toxic anterior segment syndrome, and capsular bag distension syndrome. To avoid these complications, we developed a technique in which phacoemulsification can be done without using OVDs. Read More

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February 2020

Diffuse lamellar keratitis associated with tabletop autoclave biofilms: case series and review.

J Cataract Refract Surg 2020 Mar;46(3):340-349

From the Department of Ophthalmology (Sorenson), Alta Bates Summit Medical Center, and School of Optometry (Sorenson, Tran, Evans, Lin), University of California, Berkeley, California, USA; Department of Ophthalmology (Holland), University of British Columbia, British Columbia, Vancouver, Canada; College of Pharmacy (Evans), Touro University California, Vallejo, Vision Science Graduate Group (Lin), University of California, Berkeley, California, and Moran Eye Center (Mamalis), University of Utah Medical Center, Salt Lake City, Utah, and Altos Eye Physicians (Chang), Los Altos, California, USA.

Purpose: To report a diffuse lamellar keratitis (DLK) cluster attributed to autoclave reservoir biofilm and to review the risk and prevention of DLK and toxic anterior segment syndrome (TASS) caused by such biofilms.

Setting: Refractive Surgery Center, University of California, Berkeley.

Design: Observational case-control study and review of literature. Read More

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Corneal higher-order aberrations in Stevens-Johnson syndrome and toxic epidermal necrolysis.

Ocul Surf 2019 10 17;17(4):722-728. Epub 2019 Jul 17.

Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Purpose: To characterize the topography patterns and quantify corneal higher-order aberrations (HOAs) in the chronic phase of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

Methods: This retrospective, consecutive case series included 84 eyes of 49 patients in the chronic phase of SJS/TEN. HOAs of the total cornea, and of the anterior and posterior surfaces were measured using anterior segment optical coherence tomography (AS-OCT). Read More

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October 2019

Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis.

Cornea 2019 Oct;38(10):1305-1308

UPMC Eye Center, Pittsburgh, PA.

Purpose: Mycoplasma pneumoniae is a common cause of pediatric respiratory infections, with a quarter having extrapulmonary complications, most commonly a mucocutaneous eruption involving the ocular surface. A detailed description of the ophthalmic manifestations in Mycoplasma-induced rash and mucositis (MIRM) is currently lacking in the scientific literature.

Methods: This is a retrospective chart review of consecutive cases of MIRM at a tertiary referral children's hospital between October 1 and December 1, 2018, with up to 2 months of follow-up. Read More

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October 2019

Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes.

Eye Contact Lens 2019 Jul;45(4):e15-e23

Sunderland Eye Infirmary (D.S.J.T., S.G.), Queen Alexandra Road, Sunderland, United Kingdom; and Academic Ophthalmology (D.S.J.T.), Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Objectives: To highlight the clinical characteristics, and visual and corneal tomographic outcomes of central toxic keratopathy (CTK) after contact lens (CL) wear and mechanical debridement.

Methods: A retrospective observational case series with literature review.

Results: Four patients (4 eyes) were included in this study; 3 (75%) females, mean age 29. Read More

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Interface Fluid Syndrome (IFS) following Toxic Anterior Segment Syndrome (TASS): not related to high intraocular pressure but to endothelial failure.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):88-93. Epub 2018 Jul 7.

Centro Oftalmológico Virgilio Galvis, Floridablanca, Colombia.

We describe the case of a 52-year-old female with past history of LASIK, 21 years earlier, without Fuchs' endothelial dystrophy, who underwent phacoemulsification and intraocular lens (IOL) implantation. During the early postoperative period severe corneal edema, anterior chamber cellularity and iris inflammation presented, accompanied by a clear space along the LASIK interface. Those findings were interpreted as part of a Toxic Anterior Segment Syndrome (TASS) and secondary interface fluid syndrome (IFS). Read More

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Toxic anterior segment syndrome: A review.

Surv Ophthalmol 2019 Jul - Aug;64(4):463-476. Epub 2019 Jan 28.

Prism Eye Institute, University of Toronto, Ontario, Canada. Electronic address:

Toxic anterior segment syndrome is a surgical complication characterized by a noninfectious anterior chamber inflammatory reaction having multiple etiologies. The clinical signs (prominent limbus-to-limbus corneal edema, anterior chamber inflammation) and symptoms (decreased visual acuity, discomfort) generally occur within the first 12-48 hours after intraocular surgery. Most patients achieve good clinical and visual outcomes when there is a prompt clinical diagnosis and adequate treatment. Read More

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December 2019

Toxic anterior segment syndrome after implantation of phakic implantable collamer lens.

Int J Ophthalmol 2019 18;12(1):175-177. Epub 2019 Jan 18.

Department of Cornea and Refractive Surgery, Conde of Valenciana Foundation Institute of Ophthalmology, Mexico City 06800, Mexico.

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January 2019

Toxic anterior segment syndrome following phakic posterior chamber IOL: a rarity.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Implantable collamer lenses (ICL) have gained popularity for correction of myopia where kerato-refractive procedures are not indicated as in cases of high myopic refractive errors. Toxic anterior segment syndrome (TASS) is a very uncommonly reported postoperative complication following ICL implantation. A young patient developed severe corneal oedema and anterior segment inflammation on the first day after ICL implantation. Read More

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December 2018

[Complications of intracameral cefuroxime in cataract surgery].

Vestn Oftalmol 2018;134(5):104-110

Volga District Medical Centre, Federal Medical and Biological Agency, 2 Nizhnevolgskaya Naberegnaya, Nizhny Novgorod, Russian Federation, 603001.

Intracameral injection of cefuroxime during phacoemulsification is considered effective in preventing endophthalmitis. Its widespread usage has led to the accumulation of data on local and systemic adverse reactions. The analysis of complications of cataract surgery with cefuroxime injections described in literature has allowed identifying a few different clusters of toxic and allergic reactions to intracameral cefuroxime for the first time. Read More

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The evolution of toxic anterior segment syndrome.

Curr Opin Ophthalmol 2019 Jan;30(1):50-55

Department of Ophthalmology, Rabin Medical Center, Petach Tikva.

Purpose Of Review: Toxic anterior segment syndrome (TASS) is a surgical complication resulting from a noninfectious inflammatory reaction to substances used during intraocular ophthalmic surgery. Continuous reporting of new information concerning risk factors and possible causes is critical for preventing this condition.

Recent Findings: The diagnosis of TASS is clinical and its main features are well known. Read More

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January 2019

Anterior chamber fibrinoid syndrome after cataract extraction in a patient on ibrutinib for B-cell chronic lymphocytic leukemia: a case report and review of the literature.

J Med Case Rep 2018 Nov 16;12(1):349. Epub 2018 Nov 16.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 N. 39th St, Philadelphia, PA, 19104, USA.

Background: Ibrutinib is a tyrosine kinase inhibitor commonly used in patients with chronic lymphocytic leukemia. Based on the published literature, it has a very sound ophthalmologic safety profile. In the following, we describe a case of anterior chamber fibrinoid syndrome in a patient on ibrutinib for B-cell chronic lymphocytic leukemia after uncomplicated cataract extraction. Read More

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November 2018

Cluster endophthalmitis due to following intravitreal bevacizumab: outcomes of patients from North India.

Br J Ophthalmol 2019 09 12;103(9):1278-1283. Epub 2018 Nov 12.

Advanced Eye Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Purpose: To study features, management and outcomes of cluster endophthalmitis following intravitreal bevacizumab (BCZ) injection in North India.

Methods: In this retrospective study, 28 patients (23 men) (mean age of 59.07±13 years) who received intravitreal injection of BCZ were included. Read More

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September 2019

Toxic anterior segment syndrome-an updated review.

BMC Ophthalmol 2018 Oct 25;18(1):276. Epub 2018 Oct 25.

Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Toxic anterior segment syndrome (TASS) can be a rare complication of anterior segment surgery. Here we reviewed the most recent advances in the understanding of TASS.

Methods: English articles related to TASS were retrieved from "PubMed" using the following keywords; "toxic anterior segment syndrome" or "TASS". Read More

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October 2018

Interface fluid syndrome secondary to endothelial failure due to toxic anterior segment syndrome after cataract surgery.

Eur J Ophthalmol 2019 May 11;29(3):NP1-NP4. Epub 2018 Sep 11.

2 Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.

Purpose: To present a case of previous laser in situ keratomileusis with interface fluid syndrome secondary to toxic anterior segment syndrome following cataract surgery.

Case Report: A 52-year-old woman, complaining blurred vision in her right eye for 18 months after cataract surgery, was referred to our clinic. She was diagnosed with toxic anterior segment syndrome, postoperatively, which resolved in 3 days. Read More

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Descemet membrane endothelial keratoplasty in multifocal pseudophakic eyes.

Arq Bras Oftalmol 2018 Jun;81(3):183-187

Departamento de Oftalmologia, Hospital Oftalmológico de Sorocaba, Banco de Olhos de Sorocaba, Sorocaba, SP, Brazil.

Purpose: This report describes the use of Descemet membrane endothelial keratoplasty for the management of endothelial decompensation after multifocal intraocular lens implantation.

Methods: In this retrospective study, we reviewed and assessed the surgical outcomes of 9 patients (9 eyes) who underwent Descemet membrane endothelial keratoplasty after multifocal intraocular lens implantation.

Results: Corneal edema occurred due to Fuchs endothelial corneal dystrophy (n=3), pseudophakic bullous keratopathy (n=3), Descemet's membrane detachment (n=2), and toxic anterior segment syndrome (n=1). Read More

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Guidelines for the cleaning and sterilization of intraocular surgical instruments.

J Cataract Refract Surg 2018 Jun 13;44(6):765-773. Epub 2018 Jun 13.

From the Altos Eye Physicians (Chang), Los Altos, California, and the John A. Moran Eye Center (Mamalis), University of Utah, Salt Lake City, Utah, USA.

These Guidelines for the Cleaning and Sterilization of Intraocular Surgical Instruments were written by the Ophthalmic Instrument Cleaning and Sterilization (OICS) Task Force, comprised of representatives of the American Society of Cataract and Refractive Surgery, the American Academy of Ophthalmology, and the Outpatient Ophthalmic Surgery Society. These consensus subspecialty guidelines include evidence-based recommendations regarding issues that may be unique to the cleaning and sterilization of intraocular instrumentation. A newly published OICS Task Force study supports the safety of common short-cycle instrument processing practices for sequential same-day anterior segment surgery. Read More

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Limbal Stem Cell Deficiency-Demography and Underlying Causes.

Am J Ophthalmol 2018 04 31;188:99-103. Epub 2018 Jan 31.

Cornea and Anterior Segment Services, Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, India. Electronic address:

Purpose: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD.

Design: Retrospective, multicenter case series.

Setting: Two large tertiary care ophthalmology hospitals. Read More

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Prevention and management of postoperative endophthalmitis: A case-based approach.

Indian J Ophthalmol 2017 Dec;65(12):1396-1402

Centre for Sight, New Delhi, India.

Endophthalmitis following intraocular surgery is a disastrous complication and can lead to poor visual outcomes and loss of globe integrity. It should be differentiated from toxic anterior segment syndrome (TASS) where management differs drastically. This article presents basic knowledge about postoperative endophthalmitis and describes nine different real-world scenarios ranging from TASS to milder forms of endophthalmitis responding to intravitreal antibiotics alone and more complicated forms associated with corneal involvement, fungal endophthalmitis and cases requiring intraocular lens removal, radical vitrectomy with hyaloid peeling, base dissection, and silicone oil. Read More

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December 2017

Corneal edema after phacoemulsification.

Indian J Ophthalmol 2017 Dec;65(12):1381-1389

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Phacoemulsification is the most commonly performed cataract surgery in this era. With all the recent advances in investigations and management of cataract through phacoemulsification, most of the patients are able to achieve excellent visual outcome. Corneal edema after phacoemulsification in the immediate postoperative period often leads to patient dissatisfaction and worsening of outcome. Read More

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December 2017