874 results match your criteria Tourette Syndrome and Other Tic Disorders


Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats.

J Vis Exp 2021 May 27(171). Epub 2021 May 27.

The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center, Bar-Ilan University;

Motor tics are sudden, rapid, recurrent movements that are the key symptoms of Tourette syndrome and other tic disorders. The pathophysiology of tic generation is associated with abnormal inhibition of the basal ganglia, particularly its primary input structure, the striatum. In animal models of both rodents and non-human primates, local application of GABAA antagonists, such as bicuculline and picrotoxin, into the motor parts of the striatum induces local disinhibition resulting in the expression of motor tics. Read More

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Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study.

Mov Disord 2021 Jun 12. Epub 2021 Jun 12.

Clinical Research Center Core Facility, Hannover Medical School, Hannover, Germany.

Background: Modulation of the endocannabinoid system via monoacylglycerol lipase inhibition with Lu AG06466 (formerly known as ABX-1431) has previously been shown to reduce tics in patients with Tourette syndrome.

Objective: The aim of this study was to evaluate the efficacy and safety of Lu AG06466 in reducing tics, premonitory urges, and comorbidities in patients with Tourette syndrome.

Methods: This was a 12-week, multicenter, randomized, placebo-controlled, double-blind clinical trial of Lu AG06466 given at two dose levels in 49 adults with Tourette syndrome. Read More

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Dissociation of tic generation from tic expression during the sleep-wake cycle.

iScience 2021 Apr 31;24(4):102380. Epub 2021 Mar 31.

The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel.

Motor tics, the hallmark of Tourette syndrome (TS), are modulated by different behavioral and environmental factors. A major modulating factor is the sleep-wake cycle in which tics are attenuated to a large extent during sleep. This study demonstrates a similar reduction in tic expression during sleep in an animal model of chronic tic disorders and investigates the underlying neural mechanism. Read More

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Inhibitory control in children with tic disorder: aberrant fronto-parietal network activity and connectivity.

Brain Commun 2021 9;3(2):fcab067. Epub 2021 Apr 9.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Chronic tic disorders, including Tourette syndrome, are typically thought to have deficits in cognitive inhibition and top down cognitive control due to the frequent and repetitive occurrence of tics, yet studies reporting task performance results have been equivocal. Despite similar behavioural performance, individuals with chronic tic disorder have exhibited aberrant patterns of neural activation in multiple frontal and parietal regions relative to healthy controls during inhibitory control paradigms. In addition to these top down attentional control regions, widespread alterations in brain activity across multiple neural networks have been reported. Read More

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Tic disorders in children and adolescents: does the clinical presentation differ in males and females? A report by the EMTICS group.

Eur Child Adolesc Psychiatry 2021 May 4. Epub 2021 May 4.

Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, c/ Villarroel 170, Section 11 Floor 3, 08036, Barcelona, Spain.

Tic disorders have a strong male predominance, with a male-to-female ratio of 4:1 in Tourette syndrome (TS) and 2:1 in persistent tic disorders. In other neurodevelopmental conditions, such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), the disparity in sex distribution has been partially related to differences in symptom presentation between males and females. In tic disorders, however, little research has been conducted on this topic, probably due to the limited access to large samples with a significant proportion of females. Read More

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Is Persistent Motor or Vocal Tic Disorder a Milder Form of Tourette Syndrome?

Mov Disord 2021 May 4. Epub 2021 May 4.

Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

Background: Persistent motor or vocal tic disorder (PMVT) has been hypothesized to be a forme fruste of Tourette syndrome (TS). Although the primary diagnostic criterion for PMVT (presence of motor or vocal tics, but not both) is clear, less is known about its clinical presentation.

Objective: The goals of this study were to compare the prevalence and number of comorbid psychiatric disorders, tic severity, age at tic onset, and family history for TS and PMVT. Read More

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Comorbid chronic tic disorder and tourette syndrome in children requiring inpatient mental health treatment.

Clin Child Psychol Psychiatry 2021 Apr 16:13591045211007918. Epub 2021 Apr 16.

National and Specialist Acorn Lodge Inpatient Children's Unit, Child and Adolescent Mental Health Services, South London and the Maudsley NHS Foundation Trust, London, UK.

Objective: Children needing admission to an inpatient mental health unit often present with severe neuropsychiatric disorders characterised by complex psychopathology. We aimed to examine all admitted children with comorbid chronic tic disorder (CTD) and Tourette syndrome (TS) over a 10-year period and determine the clinical significance of these diagnoses.

Method: A retrospective, naturalistic study was conducted, comparing children with and without CTD/TS in terms of co-morbid diagnoses, medication use, access to education, aggression contributing to the admission, duration of admission, functional outcomes and satisfaction with treatment. Read More

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Clinical Correlates of Health-Related Quality of Life in Adults With Chronic Tic Disorder.

Front Psychiatry 2021 10;12:619854. Epub 2021 Mar 10.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Tics are the hallmark feature of Tourette syndrome (TS), but psychiatric and sensory symptoms are widely prevalent and increasingly recognized as core manifestations of the disorder. Accumulating evidence suggests that these psychiatric and sensory symptoms exert greater influence on quality of life (QOL) than tics themselves. However, much remains uncertain about determinants of QOL in TS due to the complexity of the clinical presentation. Read More

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Yale Global Tic Severity Scale (YGTSS): Psychometric Quality of the Gold Standard for Tic Assessment Based on the Large-Scale EMTICS Study.

Front Psychiatry 2021 25;12:626459. Epub 2021 Feb 25.

Clinic of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany.

The Yale Global Tic Severity Scale (YGTSS) is a clinician-rated instrument considered as the gold standard for assessing tics in patients with Tourette's Syndrome and other tic disorders. Previous psychometric investigations of the YGTSS exhibit different limitations such as small sample sizes and insufficient methods. To overcome these shortcomings, we used a subsample of the large-scale "European Multicentre Tics in Children Study" (EMTICS) including 706 children and adolescents with a chronic tic disorder and investigated convergent, discriminant and factorial validity, as well as internal consistency of the YGTSS. Read More

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February 2021

Clinical development of valbenazine for tics associated with Tourette syndrome.

Expert Rev Neurother 2021 Apr 1;21(4):393-404. Epub 2021 Apr 1.

Medical Affairs, Neurocrine Biosciences, Inc., San Diego, CA, USA.

: Significant need exists for effective, well-tolerated pharmacologic treatments for Tourette syndrome (TS). Medications that inhibit vesicular monoamine transporters (i.e. Read More

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Rhabdomyolysis secondary to severe tic fits.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA

Tourette syndrome (TS) is a condition wherein motor and vocal tics occur, provoked by an urge, but often not able to be completely voluntarily controlled. Tics are known to cause physical and emotional risks to quality of life, and in rare extreme cases, may have permanent consequences. We report the first cases, to our knowledge, of rhabdomyolysis due to extreme tic fits in two distinct patients with TS. Read More

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Aripiprazole for the treatment of Tourette syndrome.

Expert Rev Neurother 2021 Apr 26;21(4):381-391. Epub 2021 Feb 26.

Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, UK.

: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by multiple tics which often persisting in forms of different severity throughout adult life. The prevalence of neuropsychiatric co-morbidity in patients with TS is high. Treatment of TS can involve pharmacological, behavioral, or, in rare cases, surgical therapies. Read More

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Tourette syndrome research highlights from 2019.

F1000Res 2020 11;9:1314. Epub 2020 Nov 11.

Department of Psychiatry, Neurology, and Radiology,, Washington University School of Medicine, Saint Louis, MO, 63110, USA.

This is the sixth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2019 relevant to Tourette syndrome and other tic disorders. The highlights from 2020 is being drafted on the Authorea online authoring platform; readers are encouraged to add references or give feedback on our selections comments feature on this page. After the calendar year ends, this article is submitted as the annual update for the Tics collection F1000Research. Read More

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Tics in patients with encephalitis.

Neurol Sci 2021 Apr 23;42(4):1311-1323. Epub 2021 Jan 23.

Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, UK.

Background: Movement disorders have been described in the context of different types of encephalitis. Among hyperkinetic manifestations, tics have sporadically been reported in cases of encephalitis resulting from a range of aetiologies.

Objective: This review aimed to assess the prevalence and characteristics of tics in patients with encephalitis. Read More

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Maternal autoimmunity and inflammation are associated with childhood tics and obsessive-compulsive disorder: Transcriptomic data show common enriched innate immune pathways.

Brain Behav Immun 2021 05 8;94:308-317. Epub 2021 Jan 8.

Kids Neuroscience Centre, The Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; The Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. Electronic address:

Although genetic variation is a major risk factor of neurodevelopmental disorders, environmental factors during pregnancy and early life are also important in disease expression. Animal models demonstrate that maternal inflammation causes fetal neuroinflammation and neurodevelopmental deficits, and brain transcriptomics of neurodevelopmental disorders in humans show upregulated differentially expressed genes are enriched in immune pathways. We prospectively recruited 200 sequentially referred children with tic disorders/obsessive-compulsive disorder (OCD), 100 autoimmune neurological controls, and 100 age-matched healthy controls. Read More

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Study protocol to investigate the correlation between Tourette syndrome and allergy in children and adolescents.

J Int Med Res 2020 Dec;48(12):300060520973921

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Objective: Noting that the usefulness of cases diagnosed in administrative registers is dependent on diagnostic validity, in this study, we aim to elucidate the correlation between Tourette syndrome and allergy in children and adolescents, specifically with regard to incidence of asthma, allergic rhinitis, allergic conjunctivitis, and atopic dermatitis.

Methods: Based on a set of inclusion and exclusion criteria, we intend to enroll 200 children and adolescents aged 18 years and younger, accompanied by their parents, for a duration of 2 years. We will administer an anonymous questionnaire in a case-control study. Read More

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December 2020

Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder.

Neuropsychiatr Dis Treat 2020 2;16:2591-2601. Epub 2020 Nov 2.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Sensory hypersensitivity, defined as heightened awareness of and reactivity to external stimuli, is a bothersome symptom that affects up to 80% of adults with Tourette syndrome (TS). Such widespread prevalence suggests sensory hypersensitivity is a core feature of the disorder, but its severity and association with other clinical features of TS remain largely unexplored. Complicating matters, sensory hypersensitivity has been observed in two neurodevelopmental disorders commonly comorbid with TS: obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). Read More

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November 2020

Using Online Support Communities for Tourette Syndrome and Tic Disorders: Online Survey of Users' Experiences.

J Med Internet Res 2020 11 3;22(11):e18099. Epub 2020 Nov 3.

Division of Psychiatry & Applied Psychology, Institute of Mental Health, The University of Nottingham, Nottingham, United Kingdom.

Background: People living with a tic disorder (TD)-such as Tourette syndrome (TS)-experience many negative psychological and social challenges arising from chronic tics, such as stigmatization from peers and poorer quality of life, and these can impact upon their families too. It can be difficult for this population to access face-to-face support for tics, and so online support communities offer one avenue for support from peers facing similar experiences. However, little is known about how online support communities may be used by people with TS and other TDs, and by others (eg, parents, caregivers) supporting a person with TS/TD. Read More

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November 2020

[Investigation on the status of monotherapy for newly diagnosed tic disorders and its comorbidity in children].

Zhonghua Er Ke Za Zhi 2020 Nov;58(11):887-892

Department of Pediatrics, Beijing Anding Hospital Affiliated to Capital Medical University, Beijing 100088, China.

To investigate the status of monotherapy for newly diagnosed tic disorders and its comorbidity in children, so as to provide a reference for clinical medication. A questionnaire survey was conducted to collect the application experience of monotherapy for newly diagnosed tic disorders and comorbidities in 110 pediatric neurologists and psychiatrists from Chinese Tic Disorders Study Consortium from February to August in 2019. Doctors were asked to rate treatment options based on a rank 5-point scale with "1" least appropriate and "5" most appropriate. Read More

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November 2020

Sensory symptoms in body-focused repetitive behaviors, restless legs syndrome, and Tourette syndrome: An overlap?

Neurosci Biobehav Rev 2020 12 18;119:320-332. Epub 2020 Oct 18.

Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, United Kingdom; School of Life and Health Sciences, Aston University, Birmingham, United Kingdom; University College London and Institute of Neurology, London, United Kingdom. Electronic address:

Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple tics. Sensory symptoms play a key role in the clinical phenomenology and pathophysiology of TS, as most patients report premonitory urges driving tic expression. Interestingly, sensory symptoms have also been reported in other conditions characterized by repeated behaviors. Read More

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December 2020

What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders?

Front Neurol 2020 16;11:567407. Epub 2020 Sep 16.

Child Study Center, Yale University, New Haven, CT, United States.

The goal of this article is to review the past decade's literature and provide a critical commentary on the involvement of immunological mechanisms in normal brain development, as well as its role in the pathophysiology of Tourette syndrome, other Chronic tic disorders (CTD), and related neuropsychiatric disorders including Obsessive-compulsive disorder (OCD) and Attention deficit hyperactivity disorder (ADHD). We conducted a literature search using the Medline/PubMed and EMBASE electronic databases to locate relevant articles and abstracts published between 2009 and 2020, using a comprehensive list of search terms related to immune mechanisms and the diseases of interest, including both clinical and animal model studies. The cellular and molecular processes that constitute our "immune system" are crucial to normal brain development and the formation and maintenance of neural circuits. Read More

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September 2020

Rage attacks in Tourette Syndrome and Chronic Tic Disorder: a systematic review.

Neurosci Biobehav Rev 2020 12 25;119:21-36. Epub 2020 Sep 25.

Department of Human Neurosciences, Institute of Child and Adolescent Neuropsychiatry, Sapienza University of Rome - Italy, Via dei Sabelli, 108, 00185 Rome, Italy. Electronic address:

Tourette syndrome (TS) and chronic motor/vocal tic disorder (CTD) are neurodevelopmental conditions defined by the occurrence of multiple tics. Besides the well-known association with attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), rage attacks (RA) represent common and detrimental symptoms for patients. Inorder to explore prevalence of RA in tic disorders, relation to tic severity/comorbidities and available treatments, we performed a systematic literature review based on PRISMA Guidelines. Read More

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December 2020

Current Status, Diagnosis, and Treatment Recommendation for Tic Disorders in China.

Front Psychiatry 2020 13;11:774. Epub 2020 Aug 13.

Department of Pediatrics, Peking University People's Hospital, Beijing, China.

Tic disorders (TD) are a group neuropsychiatric disorders with childhood onset characterized by tics, i.e. repetitive, sudden, and involuntary movements or vocalizations; and Tourette syndrome (TS) is the most severe form of TD. Read More

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A pediatric neurobehavioral treatment challenge.

eNeurologicalSci 2020 Sep 20;20:100244. Epub 2020 May 20.

10225 Hickorywood Hill Ave Suite B, Huntersville, NC 28078, United States.

Tourette 's syndrome (TS) currently has very limited FDA approved treatment options, despite the fact that TS and other pediatric tic disorders are not uncommon and can cause significant emotional and physical distress for patients and their families. For providers who regularly see these conditions in practice this inadequacy is highly frustrating on the treatment side as there are such limited options to offer to these families, and the outcome to hope for is not highly optimistic. The outcome of this case presentation is an example of how health care providers can use clinical knowledge in combination with evidence-based practice to advocate for their patients and find new solutions that could be, and in this case were, life changing. Read More

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September 2020

Sensory hypersensitivity in Tourette syndrome: A review.

Brain Dev 2020 Oct 26;42(9):627-638. Epub 2020 Jun 26.

Department of Pediatrics, Division of Child Neurology, Vanderbilt Children's Hospital, United States.

Tourette syndrome (TS) is a neurodevelopmental disorder defined by tics, but most patients also experience bothersome sensory phenomena, in the form of premonitory urges and/or sensory hypersensitivity. Whereas premonitory urges are temporally paired with tics, sensory hypersensitivity is a constant, heightened awareness of external and/or internal stimuli. The intensity of sensory hypersensitivity does not strongly correlate with the severity of tics or premonitory urges, suggesting it is a dissociable clinical phenomenon. Read More

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October 2020

Case Report: DSM-5 misses an edge case in tic disorders nosology.

Authors:
Kevin J Black

F1000Res 2020 3;9:505. Epub 2020 Jun 3.

Departments of Psychiatry, Neurology, Radiology and Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110-1093, USA.

A boy with multiple phonic tics, one lifetime motor tic, and no impairment or marked distress does not meet criteria for any DSM-5 tic disorder diagnosis. The next version of the Diagnostic and Statistical Manual should adjust the criteria for Tourette's Disorder and/or for "other specified tic disorder" and "unspecified tic disorder." Read More

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Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up.

J Clin Med 2020 Jun 3;9(6). Epub 2020 Jun 3.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

Previous studies have investigated differences in the volumes of subcortical structures (e.g., caudate nucleus, putamen, thalamus, amygdala, and hippocampus) between individuals with and without Tourette syndrome (TS), as well as the relationships between these volumes and tic symptom severity. Read More

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Characteristics of diffusion tensor imaging of central nervous system in children with tourette's disease.

Medicine (Baltimore) 2020 May;99(22):e20492

Department of Radiology.

To investigate the characteristics of diffusion tensor imaging (DTI) of the central nervous system in children with Tourette syndrome (TS).Fifteen children with TS (TS group) and 15 normal children (control group) were studied, and all of them underwent DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) parameters were calculated using the DTIStudio software. Read More

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Depression in Tourette Syndrome.

Psychiatr Pol 2020 Feb 29;54(1):69-82. Epub 2020 Feb 29.

Zakład Psychologii Klinicznej i Neuropsychologii Uniwersytetu Gdańskiego.

Objectives: The aim of the study is to show relationship between severity of depressive symptoms and the severity of tics, declared feeling of stigmatization and feelings about the body.

Methods: The study included 13 people with Tourette syndrome and 13 people in a comparative group - matching method, taking into account compatibility of gender, age, number of years of education, and size of the place of residence. The study used: Polish adaptation of the Yale Global Tic Severity Scale (YGTSS), Questionnaire for Measuring Depression (Kwestionariusz do Pomiaru Depresji -KPD), Perceived Stigmatization Questionnaire (PSQ), Questionnaire of feelings about the body. Read More

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February 2020

Tackle your Tics: pilot findings of a brief, intensive group-based exposure therapy program for children with tic disorders.

Eur Child Adolesc Psychiatry 2021 Mar 20;30(3):461-473. Epub 2020 May 20.

Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands.

Tourette syndrome (TS) and other chronic tic disorders (CTD) are prevalent neurodevelopmental disorders, which can have a huge burden on families and society. Behavioral treatment is a first-line intervention for tic disorders. Despite demonstrated efficacy, tic reduction and utilization rates of behavioral treatment remain relatively low. Read More

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