5,065 results match your criteria Tourette Syndrome


Association of Antipsychotic Treatment With Risk of Unexpected Death Among Children and Youths.

JAMA Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Importance: Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown.

Objective: To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications.

Design, Setting, And Participants: This retrospective cohort study was conducted from 1999 through 2014 and included Medicaid enrollees aged 5 to 24 years in Tennessee who had no diagnosis of severe somatic illness, schizophrenia or related psychoses, or Tourette syndrome or chronic tic disorder. Read More

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December 2018
1 Read

Predictors of Receipt of School Services in a National Sample of Youth With ADHD.

J Atten Disord 2018 Dec 10:1087054718816169. Epub 2018 Dec 10.

3 Centers for Disease Control and Prevention, Atlanta, GA, USA.

Objective: The objective of the study is to describe the extent to which students with ADHD received school-based intervention services and identify demographic, diagnostic, and impairment-related variables that are associated with service receipt in a large, nationally drawn sample.

Method: Parent-reported data were obtained for 2,495 children with ADHD aged 4 to 17 years from the National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome (NS-DATA).

Results: The majority (69. Read More

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December 2018

An exploratory study into an adapted use of the Alert Program for tic disorder in children.

Australas Psychiatry 2018 Dec 3:1039856218815750. Epub 2018 Dec 3.

Paediatric Neurologist, Department of Paediatric Neurology, The Children's Hospital at Westmead, Sydney, NSW, and; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Objectives:: This preliminary study explored whether an adapted approach to the Alert Program, that uses sensorimotor strategies, might assist with management of tic disorders in children. The Alert Program, a program that uses sensorimotor strategies for self-regulation in children with neurodevelopmental disorders, had not been trialled with children with tic disorders.

Methods:: Ten children with tic disorder were assessed using the Dunn Sensory Profile 2 (SP2), the Yale Global Tic Severity Scale (YGTSS) and the Parent Tic Questionnaire (PTQ). Read More

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December 2018

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

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December 2018
3 Reads

Prefrontal Cortical Stimulation in Tourette Disorder: Proof-of-concept Clinical and Neuroimaging Study.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):499-505. Epub 2018 Oct 3.

Department of Neurology Catholic University of the Sacred Heart Milan Italy.

Background: The benefits of neurosurgery in Tourette Syndrome (TS) are still incompletely understood. Prefrontal cortical electrical stimulation offers a less invasive alternative to deep brain stimulation.

Objective: To perform a pilot assessment on safety and efficacy of prefrontal cortical bilateral electrical stimulation in TS using clinical and brain metabolic assessments. Read More

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October 2018
1 Read

Deep brain stimulation for Gilles de la Tourette syndrome in children and youth: a meta-analysis with individual participant data.

Authors:

J Neurosurg Pediatr 2018 Oct 1:1-11. Epub 2018 Oct 1.

OBJECTIVEGilles de la Tourette syndrome (GTS) is a disorder characterized by motor and vocal tics. Although by definition the onset of GTS is before age 18 years, clinical trials of deep brain stimulation (DBS) have been conducted only in adults. Using individual participant data (IPD) meta-analysis methodology, the current study investigated the safety and efficacy of DBS as a treatment for GTS in children and youth. Read More

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October 2018
1 Read

Relationship Between Physical Activity, Tic Severity and Quality of Life in Children with Tourette Syndrome.

J Can Acad Child Adolesc Psychiatry 2018 Nov 1;27(4):222-227. Epub 2018 Nov 1.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario.

Objective: To examine the relationship between physical activity, tic severity and quality of life (QoL) in children and adolescents with persistent tic disorder and Tourette Syndrome.

Method: Baseline data was examined from a larger randomized controlled trial (Clinicaltrials.gov NCT02153463). Read More

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November 2018

Intact automatic motor inhibition in patients with tourette syndrome.

Mov Disord 2018 Nov;33(11):1800-1804

Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.

Background: Behavioral disinhibition has been proposed as a key mechanism in Tourette syndrome. Yet classic inhibition tasks have yielded inconsistent results, likely reflecting interference by strategies compensating for tic release.

Methods: We examined a core inhibitory function that is immune to such interference because it suppresses movements automatically. Read More

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November 2018
3 Reads

The Prevalence of Parent-Reported Autism Spectrum Disorder Among US Children.

Pediatrics 2018 Dec;142(6)

Office of the Dean, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia.

: media-1vid110.1542/5839990273001PEDS-VA_2017-4161 OBJECTIVES: To estimate the national prevalence of parent-reported autism spectrum disorder (ASD) diagnosis among US children aged 3 to 17 years as well as their treatment and health care experiences using the 2016 National Survey of Children's Health (NSCH).

Methods: The 2016 NSCH is a nationally representative survey of 50 212 children focused on the health and well-being of children aged 0 to 17 years. Read More

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December 2018
4 Reads

Neuroimaging Applications in Tourette's Syndrome.

Int Rev Neurobiol 2018 12;143:65-108. Epub 2018 Oct 12.

Centre de Référence National Maladie Rare 'Syndrome Gilles de la Tourette, Paris, France; Sorbonne Université, UMR S 1127, CNRS UMR 7225, ICM, Paris, France; Départment de Physiologie, Hôpital Saint-Antoine, Paris, France.

Tics are neurodevelopmental hyperkinetic symptoms typically associated with unpleasant sensory experiences called premonitory urges. Tourette syndrome (TS) is the primary chronic tic disorder for which medical surveillance is most frequently required, and is associated with a complex phenotypical spectrum encompassing different types of abnormal behaviors. Animal models of tics support their link to phasic activity changes throughout the sensorimotor loop of the cortico-basal ganglia-thalamo-cortical network. Read More

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October 2018
6 Reads

Sex differences in the genetic architecture of obsessive-compulsive disorder.

Am J Med Genet B Neuropsychiatr Genet 2018 Nov 20. Epub 2018 Nov 20.

Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois.

Obsessive-compulsive disorder (OCD) is a highly heritable complex phenotype that demonstrates sex differences in age of onset and clinical presentation, suggesting a possible sex difference in underlying genetic architecture. We present the first genome-wide characterization of the sex-specific genetic architecture of OCD, utilizing the largest set of OCD cases and controls available from the Psychiatric Genomics Consortium. We assessed evidence for several mechanisms that may contribute to sex differences including a sex-dependent liability threshold, the presence of individual sex-specific risk variants on the autosomes and the X chromosome, and sex-specific pleiotropic effects. Read More

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November 2018
5 Reads

Critical aspects in the legal defence of patients with Tourette's Syndrome: An Italian case series.

Int J Law Psychiatry 2018 Nov - Dec;61:1-5. Epub 2018 Sep 22.

Studio Alleva, 6 V. Monti Street, 20100 Milan, Italy. Electronic address:

Tourette's syndrome (TS) is a developmental neurobehavioral disorder with childhood onset and relevant burden in terms of disability and reduced quality of life. In Italy the biological basis of this syndrome is still frequently ignored and TS is often recognised as a psychiatric manifestation, or even it is not recognised as pathology, which may result in inadequate treatment, social isolation and improper hospitalization. Indeed, the organic medical nature of TS needs to be taken into great consideration in evaluating causality of committing crimes in affected patients. Read More

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September 2018
3 Reads

Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome.

J Clin Neuromuscul Dis 2018 Dec;20(2):94-98

Departments of Pediatrics and.

Severe recurrent proximal muscle weakness without neuroleptic malignant syndrome secondary to antidopaminergic medication has rarely been reported. We report a 29-year-old man with history of obsessive compulsive disorder and Tourette syndrome who presented with 2 months of worsening dyspnea 3 weeks after starting ziprasidone 40 mg daily that required mechanical ventilation. A year before, after an increased risperidone dose from 0. Read More

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December 2018
6 Reads

Infection of Wildlife by in France Assessment Through a National Surveillance System, Sylvatub.

Front Vet Sci 2018 30;5:262. Epub 2018 Oct 30.

Anses, Nancy Laboratory for Rabies and Wildlife, Malzéville, France.

infection was first described in free-ranging wildlife in France in 2001, with subsequent detection in hunter-harvested ungulates and badgers in areas where outbreaks of bovine tuberculosis (TB) were also detected in cattle. Increasing concerns regarding TB in wildlife led the French General Directorate for Food (DGAL) and the main institutions involved in animal health and wildlife management, to establish a national surveillance system for TB in free-ranging wildlife. This surveillance system is known as "Sylvatub. Read More

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October 2018
3 Reads

Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort.

Biol Psychiatry 2018 Sep 29. Epub 2018 Sep 29.

Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Tourette syndrome (TS) has a well-established genetic background, but its genetic architecture remains largely unknown. The authors investigated the role of polygenic risk scores (PRSs) derived from a TS genome-wide association study in relation to the occurrence of tics and associated traits in a general population cohort.

Methods: Using the most recent TS genome-wide association study (n = 4819 cases; n = 9488 controls) as the discovery sample, PRSs were calculated in Avon Longitudinal Study of Parents and Children participants (n = 8941). Read More

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September 2018
2 Reads

[Tourette Syndrome].

Brain Nerve 2018 Nov;70(11):1237-1245

Department of Child and Adolescent Psychiatry, Tokyo Metropolitan Children's Medical Center.

Tourette syndrome (TS) is a neurodevelopmental disorder. TS was formerly considered to be a psychogenic disease; however, TS has recently been thought to be a heterogeneous disease with neurological bases and involving environmental and genetic factors. For example, it has been suggested that neurotransmitters including dopamine and cortico-striato-thalamo-cortical circuits are suggested to be associated with TS pathogenesis. Read More

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November 2018
1 Read

A Systematic Review of the Utility of Electroconvulsive Therapy in Broadly Defined Obsessive-Compulsive-Related Disorders.

Prim Care Companion CNS Disord 2018 Oct 18;20(5). Epub 2018 Oct 18.

Rua Visconde de Pirajá, 547, Sala 617, Ipanema, Rio de Janeiro, CEP: 22410-003.

Objective: To assess the efficacy of electroconvulsive therapy (ECT) in DSM-5 obsessive-compulsive-related disorders (OCRDs) and conditions subsumed under an "extended" OCD spectrum, including tic disorders and self-injurious behaviors.

Data Sources: A systematic search of the MEDLINE, Web of Science, Scopus, and LILACS databases and other sources was performed between June 6 and July 2, 2017. Search terms included (Autis*) AND (ECT OR electroconvulsive), (Self-injur*) AND (ECT OR electroconvulsive), (Tic* OR Tourette) AND (ECT OR electroconvulsive), (Body Dysmorphic Disorder OR Dysmorphophobi*) AND (ECT OR electroconvulsive), (Hoard*) AND (ECT OR electroconvulsive), (Trichotillomani*) AND (ECT OR electroconvulsive), (Skin Picking OR Excoriation) AND (ECT OR electroconvulsive), (Grooming) AND (ECT OR electroconvulsive), (Kleptomani*) AND (ECT OR electroconvulsive), and (Pyromani*) AND (ECT OR electroconvulsive). Read More

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October 2018
15 Reads

Commentary: Role of the Endogenous Opiate System in Psychiatric Disorders Other Than Addiction.

Authors:
David A Kahn

J Psychiatr Pract 2018 Nov;24(6):432-433

KAHN: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY.

Two case reports explore opiate use in relation to 2 different psychiatric disorders. In the first case report, the authors reported the finding that opiate abuse appeared to mitigate premorbid Tourette syndrome in a small series of patients with opiate addiction and that this benefit was maintained with medically supervised opiate agonist therapy. In the second case report, the authors noted a significant correlation between prescription opiate use and delusions of infestation in a large psychodermatology clinic (as well as a separate, stronger correlation with stimulant use). Read More

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November 2018
1 Read

Heroin Addiction in Serbian Patients With Tourette Syndrome.

J Psychiatr Pract 2018 Nov;24(6):424-427

SARAJLIJA, RAKETIC, and NESIC: Special Hospital for Addiction Diseases, Belgrade, Serbia.

Introduction: Tourette syndrome (TS) is a neurodevelopmental disorder with a high prevalence of psychiatric comorbidity. The most common comorbid disorder in patients with TS is attention-deficit/hyperactivity disorder (ADHD). To date, there have been few reports concerning the association of TS with addiction. Read More

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November 2018
3 Reads

Motor cortical excitability during voluntary inhibition of involuntary tic movements.

Mov Disord 2018 Nov 31;33(11):1804-1809. Epub 2018 Oct 31.

Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London, UK.

Background: Tics can be voluntarily inhibited. However, the neurophysiology of voluntary tic inhibition remains underexplored. The objective of this study was to explore state-dependent effects of voluntary tic inhibition on M1 excitability. Read More

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November 2018
10 Reads

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent.

Front Immunol 2018 9;9:2100. Epub 2018 Oct 9.

Anticancer Antibodies, CRCL, INSERM U1052, CNRS UMR 5286, CLB, UCBL, Lyon, France.

In spite of impressive response rates in multiple cancer types, immune checkpoint inhibitors (ICIs) are active in only a minority of patients. Alternative strategies currently aim to combine immunotherapies with conventional agents such as cytotoxic chemotherapies. Here, we performed a study of PD-1 or PDL-1 blockade in combination with reference chemotherapies in four fully immunocompetent mouse models of cancer. Read More

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October 2018
12 Reads

Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders.

J Med Chem 2018 Oct 11;61(20):9059-9061. Epub 2018 Oct 11.

Department of Molecular Physiology, Leiden Institute of Chemistry , Leiden University , 2333 CC Leiden , The Netherlands.

Monoacylglycerol lipase (MGLL or MAGL) is a critical point of regulation of both endocannabinoid and eicosanoid signaling pathways in the brain, thereby providing novel therapeutic opportunities for neurological and neurodegenerative diseases. In this issue Cisar et al. disclose the discovery, optimization, and initial preclinical profiling of ABX-1431, a covalent, irreversible MGLL inhibitor. Read More

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October 2018
1 Read

Face perception enhances insula and motor network reactivity in Tourette syndrome.

Brain 2018 Nov;141(11):3249-3261

Sackler Centre for Consciousness Science, University of Sussex, UK.

Tourette syndrome is a neurodevelopmental disorder, characterized by motor and phonic tics. Tics are typically experienced as avolitional, compulsive, and associated with premonitory urges. They are exacerbated by stress and can be triggered by external stimuli, including social cues like the actions and facial expressions of others. Read More

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November 2018
8 Reads

Subjective embodiment during the rubber hand illusion predicts severity of premonitory sensations and tics in Tourette Syndrome.

Conscious Cogn 2018 Oct 15;65:368-377. Epub 2018 Oct 15.

Sackler Centre for Consciousness Science, University of Sussex, UK; Department of Neuroscience, Brighton & Sussex Medical School, UK; Sussex Partnership NHS Foundation Trust, UK.

In Tourette Syndrome, the expression of tics and commonly preceding premonitory sensations is associated with perturbed subjective feelings of self-control and agency. We compared responses to the Rubber Hand Illusion in 23 adults with TS and 22 controls. Both TS and control participants reported equivalent subjective embodiment of the artificial hand: feelings of ownership, location, and agency were greater during synchronous visuo-tactile stimulation, compared to asynchronous. Read More

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October 2018
1 Read

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.

Am J Med Genet B Neuropsychiatr Genet 2018 Oct 16;177(7):641-657. Epub 2018 Oct 16.

Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), Departments of Psychiatry and Behavioral Sciences & Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York.

Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune-related phenotypes. Read More

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October 2018
5 Reads
3.420 Impact Factor

Tics and Tourette syndrome.

J Paediatr Child Health 2018 Oct;54(10):1148-1153

Department of Paediatric Neurology, University of Sydney, Sydney, New South Wales, Australia.

Tourette syndrome is a heterogeneous disorder. The genetic basis is complex, and both in utero and ex utero environmental factors may modify the phenotypic expression of the disorder. Inflammation related to aberrations in immune activation appears to play a pathogenic role in some cases. Read More

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October 2018
2 Reads

Visuomotor learning and unlearning in children and adolescents with tourette syndrome.

Cortex 2018 Dec 11;109:50-59. Epub 2018 Sep 11.

School of Medicine, University of Nottingham, UK; Institute of Mental Health, University of Nottingham, UK. Electronic address:

Tourette syndrome (TS) is a childhood-onset neurological condition characterised by an evolving repertoire of chronic motor tics and one or more phonic tics. Tics, like habits, are inflexible and repetitive behaviours that are acquired over a period of time. It has been proposed that tics arise in TS as a result of increased habit learning: which may bias the child to acquire automatic behaviours (i. Read More

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December 2018
3 Reads

Single center experience with medical cannabis in Gilles de la Tourette syndrome.

Parkinsonism Relat Disord 2018 Oct 1. Epub 2018 Oct 1.

Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Israel; Sackler School of Medicine, Tel-Aviv University, Israel; Sagol School of Neuroscience, Tel-Aviv University, Israel.

Introduction: Patients with Gilles de la Tourette syndrome (GTS) experience reduced function and impaired quality of life. The current medical treatments for this syndrome can cause significant side effects and offer partial symptomatic relief. In a few small trials medical cannabis (MC) has been suggested to offer symptomatic relief with a relatively benign side effect profile. Read More

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October 2018
11 Reads

The psychology of Tourette disorder: Revisiting the past and moving toward a cognitively-oriented future.

Clin Psychol Rev 2018 Sep 23. Epub 2018 Sep 23.

Department of Psychology, Concordia University, 7141 Sherbrooke St. West, Montreal, QC H4B 1R6, Canada. Electronic address:

Tourette syndrome is a neurodevelopmental disorder characterized by chronic tics (i.e., repetitive and stereotyped movements and vocalizations) and premonitory urges (i. Read More

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September 2018
2 Reads

Altered Functional Connectivity in Resting State Networks in Tourette's Disorder.

Front Hum Neurosci 2018 18;12:363. Epub 2018 Sep 18.

Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Brain regions are anatomically and functionally interconnected in order to facilitate important functions like cognition and movement. It remains incompletely understood how brain connectivity contributes to the pathophysiology of Tourette's disorder (TD). By using resting-state functional MRI, we aimed to identify alterations in the default mode network (DMN), frontal-parietal network (FPN), sensori-motor network (SMN), and salience network (SN) in TD compared with healthy control (HC) subjects. Read More

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September 2018
2 Reads

Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology.

Neuroscience 2018 Nov 29;392:172-179. Epub 2018 Sep 29.

Department of Psychiatry, Yale University, United States; Child Study Center, Yale University, United States; Interdepartental Neuroscience Program, Yale University, United States. Electronic address:

Histamine dysregulation has been identified as a rare genetic cause of tic disorders; mice with a knockout of the histidine decarboxylase (Hdc) gene represent a promising model of this pathophysiology. How alterations in the histamine system lead to neuropsychiatric disease, however, remains unclear. The H3R histamine receptor is elevated in the striatum of Hdc KO mice, and H3R agonists, acting in the dorsal striatum, trigger tic-like movements in the model. Read More

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November 2018
6 Reads

Low-frequency Repetitive Transcranial Magnetic Stimulation for Treatment of Tourette Syndrome: A Naturalistic Study with 3 Months of Follow-up.

Indian J Psychol Med 2018 Sep-Oct;40(5):482-486

Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.

The objective of this study is to report the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in three patients with medication-refractory Tourette syndrome (TS) and over 3-month follow-up. A review of literature on the use of rTMS for the treatment of TS is also presented. Three patients with severe, medication-refractory TS and comorbid obsessive-compulsive disorder (OCD) in two of them, received an open-label trial of rTMS at 1 Hz frequency for 4-week duration. Read More

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October 2018
8 Reads

Distinctive tics suppression network in Gilles de la Tourette syndrome distinguished from suppression of natural urges using multimodal imaging.

Neuroimage Clin 2018 19;20:783-792. Epub 2018 Sep 19.

Department of Neurology, University Medical Centre Groningen, University of Groningen, the Netherlands. Electronic address:

Background And Objectives: Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by tics. A hallmark of GTS is the ability to voluntarily suppress tics. Our aim was to distinguish the neural circuits involved in the voluntary suppression of ocular tics in GTS patients from blink suppression in healthy subjects. Read More

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September 2018
4 Reads

Software for web-based tic suppression training.

F1000Res 2017;6:2150. Epub 2017 Dec 19.

Washington University School of Medicine, St. Louis, MO, 63110, USA.

Exposure and response prevention (ERP) is a first-line behavior therapy for obsessive-compulsive disorder and Tourette syndrome (TS). However, ERP for tic disorders requires intentional tic suppression, which for some patients is difficult even for brief periods. Additionally, practical access to behavior therapy is difficult for many patients, especially those in rural areas. Read More

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December 2017
2 Reads

5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction.

Neurobiol Dis 2019 Jan 24;121:120-130. Epub 2018 Sep 24.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria SP 8, Monserrato 09042, Italy. Electronic address:

Although 1-3,4-dihydroxyphenylalanine (L-DOPA) is the mainstay therapy for treating Parkinson's disease (PD), its long-term administration is accompanied by the development of motor complications, particularly L-DOPA induced dyskinesia (LID), that dramatically affects patients' quality of life. LID has consistently been related to an excessive dopamine receptor transmission, particularly at the down-stream signaling of the striatal D receptors (DR), resulting in an exaggerated stimulation of cAMP-dependent protein kinase and extracellular signal-regulated kinase (ERK) pathway. We previously reported that pharmacological blockade of 5alpha-reductase (5AR), the rate-limiting enzyme in neurosteroids synthesis, attenuates the severity of a broad set of behavioral alterations induced by DR and DR activation, without inducing extrapyramidal symptoms. Read More

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January 2019
9 Reads

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.

Cell Rep 2018 Sep;24(13):3441-3454.e12

Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA. Electronic address:

We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We observe an overrepresentation of de novo damaging variants in simplex, but not multiplex, families; we identify a high-confidence TD risk gene, CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3); we find that the genes mutated in TD patients are enriched for those related to cell polarity, suggesting a common pathway underlying pathobiology; and we confirm a statistically significant excess of de novo copy number variants in TD. Read More

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September 2018
3 Reads

Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models.

Eur J Med Chem 2018 Oct 12;158:405-413. Epub 2018 Sep 12.

Univ. Grenoble Alpes, CNRS, DPM UMR 5063, F-38041, Grenoble, France. Electronic address:

Phosphatidylinositide 3-kinases (PI3Ks) are widely expressed enzymes involved in membrane signalization pathways. Attempts to administer inhibitors with broad activity against different isoforms have failed due to toxicity. Conversely the PI3Kδ isoform is much more selectively expressed, enabling therapeutic targeting of this isoform. Read More

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October 2018
1 Read

Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders.

Neurosci Biobehav Rev 2018 Dec 17;95:315-335. Epub 2018 Sep 17.

Center for Psychosocial Medicine, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.

Although genuine motor abnormalities (GMA) are frequently found in schizophrenia, they are also considered as an intrinsic feature of bipolar, obsessive-compulsive, and neurodevelopmental disorders with early onset such as autism, ADHD, and Tourette syndrome. Such transnosological observations strongly suggest a common neural pathophysiology. This systematic review highlights the evidence on GMA and their neuroanatomical substrates in bipolar, obsessive-compulsive, and neurodevelopmental disorders. Read More

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December 2018
2 Reads

Why does the goalkeeper eschew medication? The challenge of new treatments for tourette syndrome.

Mov Disord 2018 Aug;33(8):1236-1237

Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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August 2018
1 Read

Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls.

Psychol Med 2018 Sep 17:1-8. Epub 2018 Sep 17.

Department of Complex Trait Genetics,Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam,Amsterdam,The Netherlands.

Background: Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders. Read More

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September 2018
1 Read

Electrophysiological predictors of cognitive-behavioral therapy outcome in tic disorders.

J Psychiatr Res 2018 Oct 4;105:113-122. Epub 2018 Sep 4.

Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Montreal, Qc, Canada; Département de Neurosciences, Université de Montréal, Montreal, Qc, Canada; Département de Psychiatrie, Université de Montréal, Montreal, Qc, Canada. Electronic address:

Cognitive-behavioral therapy (CBT) constitutes an empirically based treatment for tic disorders (TD), but much remains to be learned about its impact at the neural level. Therefore, we examined the electrophysiological correlates of CBT in TD patients, and we evaluated the utility of event-related potentials (ERP) as predictors of CBT outcome. ERPs were recorded during a stimulus-response compatibility (SRC) task in 26 TD patients and 26 healthy controls. Read More

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October 2018
1 Read

Korean adults' beliefs about and social distance toward attention-deficit hyperactivity disorder, Tourette syndrome, and autism spectrum disorder.

Psychiatry Res 2018 Nov 12;269:633-639. Epub 2018 Aug 12.

Department of Research Planning, Mental Health Research Institute, National Center for Mental Health, Seoul, South Korea. Electronic address:

Given the scarcity of studies examining public beliefs regarding multiple neurodevelopmental disorders, this study compared lay beliefs regarding the etiology of attention-deficit hyperactivity disorder (ADHD), Tourette syndrome (TS), and autism spectrum disorder (ASD), and attitudes toward individuals with the disorders. We recruited 673 participants aged 20-64 years via an online panel survey in South Korea. Participants completed questionnaires regarding perceived causation of each disorder. Read More

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November 2018
2 Reads

Tourette syndrome research highlights from 2017.

F1000Res 2018 23;7:1122. Epub 2018 Jul 23.

Psychiatry, Neurology, Radiology, and Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110-1093, USA.

This is the fourth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2017 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting. The  highlights from 2018 article is being drafted on the Authorea online authoring platform, and readers are encouraged to add references or give feedback on our selections using the comments feature on that page. Read More

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July 2018
3 Reads

Unmet Need and Financial Impact Disparities for US Children with ADHD.

Acad Pediatr 2018 Sep 7. Epub 2018 Sep 7.

Division of General Pediatrics (OJ Lindly, AE Chavez, and KE Zuckerman), Doernbecher Children's Hospital, Oregon Health & Science University, Portland.. Electronic address:

Objective: The 5.1 million US children with attention-deficit/hyperactivity disorder (ADHD) have pronounced needs in education, occupational and speech therapy, and medical and behavioral treatments. Given known associations of ADHD diagnosis with race/ethnicity and parent education, this study aimed to assess how measures of socioeconomic status correlate with both adverse family financial impact of ADHD and disparities in unmet treatment need for ADHD. Read More

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September 2018
1 Read

Cathodal tDCS Over Motor Cortex Does Not Improve Tourette Syndrome: Lessons Learned From a Case Series.

Front Behav Neurosci 2018 24;12:194. Epub 2018 Aug 24.

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Klinikum der Universität München, Munich, Germany.

: Current pathophysiological hypotheses of Gilles de la Tourette Syndrome (GTS) refer to temporally abnormal neuronal activation in cortico-striato-thalamo-cortical (CSTC) networks. Modifying cortical activity by non-invasive brain-stimulation appears to be a new treatment option in GTS. : Previous studies suggested therapeutic effects of cathodal transcranial direct current stimulation (tDCS) to pre-supplementary motor areas (SMA), however, treatment modalities concerning electrode placement, current intensity and stimulation-rate have not been systematically explored. Read More

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August 2018
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Differentiating tic-related from non-tic-related impairment in children with persistent tic disorders.

Compr Psychiatry 2018 Nov 25;87:38-45. Epub 2018 Aug 25.

Marquette University, 604 N. 16th St., Milwaukee, WI 53233, United States of America. Electronic address:

Children with persistent (chronic) tic disorders (PTDs) experience impairment across multiple domains of functioning, but given high rates of other non-tic-related conditions, it is often difficult to differentiate the extent to which such impairment is related to tics or to other problems. The current study used the Child Tourette's Syndrome Impairment Scale - Parent Report (CTIM-P) to examine parents' attributions of their child's impairment in home, school, and social domains in a sample of 58 children with PTD. Each domain was rated on the extent to which the parents perceived that impairment was related to tics versus non-tic-related concerns. Read More

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November 2018
2 Reads

Ecopipam, a D1 receptor antagonist, for treatment of tourette syndrome in children: A randomized, placebo-controlled crossover study.

Mov Disord 2018 Aug 7;33(8):1272-1280. Epub 2018 Sep 7.

Psyadon Pharmaceuticals, Inc., Germantown, Maryland, USA.

Background: Dopamine D2 receptor antagonists used to treat Tourette syndrome may have inadequate responses or intolerable side effects. We present results of a 4-week randomized, double-blind, placebo-controlled crossover study evaluating the safety, tolerability, and efficacy of the D1 receptor antagonist ecopipam in children and adolescents with Tourette syndrome.

Methods: Forty youth aged 7 to 17 years with Tourette syndrome and a Yale Global Tic Severity Scale - total tic score of ≥20 were enrolled and randomized to either ecopipam (50 mg/day for weight of <34 kg, 100 mg/day for weight of >34 kg) or placebo for 30 days, followed by a 2-week washout and then crossed to the alternative treatment for 30 days. Read More

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August 2018
5 Reads

Effect of topiramate on sweat chloride level while screening for cystic fibrosis.

BMJ Case Rep 2018 Sep 5;2018. Epub 2018 Sep 5.

Department of Pediatrics, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.

Cystic fibrosis is the most common life-limiting genetic condition in Caucasians caused by Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene mutations. Sweat chloride is the current gold standard for diagnosis where values >60 mmol/L are diagnostic and values >30 mmol/L are indeterminate. There is limited literature on the effect of medications on the sweat chloride values. Read More

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September 2018
9 Reads

A peculiar condition: A history of the Jumping Frenchmen Syndrome in scientific and popular accounts.

J Hist Neurosci 2018 Oct-Dec;27(4):355-374. Epub 2018 Sep 5.

a Department of History , State University of New York at Plattsburgh , Plattsburgh , New York , USA.

In 1878, Dr. George Beard reported to other neurologists that in Maine there existed French-Canadian woodsmen who jumped when excited. Beard observed the phenomenon firsthand and his subsequent reports attracted the attention of Georges Gilles de la Tourette in France and other neurologists worldwide for a couple of decades. Read More

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September 2018
6 Reads