Search Our Scientific Publications & Authors

Lasers Med Sci 2019 Jan 19. Epub 2019 Jan 19.

Department of Physics, Indian Institute of Technology Kanpur (IITK), Kanpur, 208016, India.

In vivo detection of oral precancer has been carried out by a fluorescence-based, in-house-developed handheld probe on three groups: oral squamous cell carcinoma (OSCC), dysplastic (precancer), and control (normal). Measurements have been performed on a total of 141 patients and volunteers of different age groups. Excitation wavelength of 405 nm was used and fluorescence emission spectra were recorded in the scan range of 450. Read More

Cancer Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Oral & Maxillofacial Surgery, No. 2 Affiliated Hospital,Sun-Yat-Sen University.

MicroRNAs (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiR have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA(mtDNA) transcription remains to be determined. Here we report that the mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation (OXPHOS) and upregulation of glycolysis. Read More

Animals (Basel) 2019 Jan 17;9(1). Epub 2019 Jan 17.

School of Animal & Veterinary Sciences, University of Adelaide, Adelaide, SA 5005, Australia.

Reptiles are held at wildlife parks and zoos for display and conservation breeding programs and are increasingly being kept as pets. Reliable indicators of welfare for reptiles need to be identified. Current guidelines for the captive management of reptiles utilize resource-based, rather than animal-based indicators; the latter being a more direct reflection of affective state. Read More

Toxins (Basel) 2019 Jan 17;11(1). Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan.

Lingual dystonia is a debilitating type of oromandibular dystonia characterized by involuntary, often task-specific, contractions of the tongue muscle activated by speaking or eating. Botulinum neurotoxin (BoNT) has been used to treat lingual dystonia; however, it is known to cause serious complications, such as dysphasia and aspiration. The purpose of this study was to evaluate the efficacy and adverse effects of individualized BoNT therapy for lingual dystonia. Read More

Am J Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Pathology, North Florida Regional Medical Center.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):198-206

Department of Stomatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, China.

Objective: LncRNA MALAT1 has been proved to be involved in the development of various types of human cancers while the involvement of MALAT1 in tongue squamous cell carcinoma has not been reported. In view of this, our study aimed to investigate the functionality of MALAT1 in tongue squamous cell carcinoma.

Patients And Methods: The expression of MALAT1 in tumor tissues and adjacent healthy tissues of tongue cancer patients, and the serum from tongue cancer patients as well as healthy controls, were detected by quantitative Real Time-PCR (qRT-PCR). Read More

Cell Stress Chaperones 2019 Jan 17. Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital, Capital Medical University, Tiantanxili 4, Dongcheng District, Beijing, 100050, China.

Sirtuin 3 (Sirt3)-modified mitochondrial fission participates in the progression of several types of cancers. However, its role in tongue cancer requires investigation. The aim of our study is to determine whether Sirt3 knockdown regulates the viability of tongue cancer cells via modulating mitochondrial fission. Read More

Oncol Lett 2019 Jan 16;17(1):63-68. Epub 2018 Oct 16.

Cancer Center and Key Laboratory of Brain and Spinal Cord Injury of Liaoning Province, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China.

Inhibitor of growth family 5 (ING5) functions as a type-II tumor suppressor gene and exerts an important role in DNA repair, apoptotic induction, proliferative inhibition, chromatin remodeling and the invasion process. In the present study, immunohistochemistry was performed to characterize the expression profile of ING5 protein on a tissue microarray containing mouse and human normal tissues, and human cancer tissues, including hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), endometrial (n=96) and lung carcinoma (n=192). In the mouse tissues, ING5 expression was detected in the cytoplasm of neurons, the nephric tubule and glomerulus, alveolar epithelium, gastrointestinal glands, squamous epithelium of the skin and skeletal muscles. Read More

J Orofac Sci 2018 Jul-Dec;10(2):86-95. Epub 2019 Jan 2.

Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Affiliated to the Tamil Nadu Dr. M.G.R. Medical University.

Objective: Schizophrenia is a psychiatric disorder that requires long-term treatment. Long-term antipsychotic treatment is often associated with the emergence of tardive dyskinesia (TD), the severity of which is measured by Abnormal Involuntary Movement Scale (AIMS). This study examined the relationship among TD, orofacial musculature activity, and patient's awareness of AIM. Read More

Arch Dis Child 2019 Jan 17. Epub 2019 Jan 17.

Paediatrics, Queen's Medical Centre, Nottingham NG7 2UH, UK.

J Biol Regul Homeost Agents 2018 Jan 18;33(1). Epub 2018 Jan 18.

Department of Emergency and Organ Transplantation, Aldo Moro University, Bari, Italy.

Oral squamous cell carcinoma in patients under 20 years of age is extremely rare, the alveolar gingiva being the most frequently affected site. The metachronous occurrence (eight years later) of a dentinogenic ghost cell tumour of the anterior maxilla in the same patient has never been previously reported. The patient had been diagnosed with a poorly differentiated squamous cell carcinoma of the ventral tongue when 12 years of age and was treated by en-block resection with functional neck dissection. Read More

Ann Am Thorac Soc 2019 Jan 17. Epub 2019 Jan 17.

University of Michigan, Pulmonary & Critical Care, Ann Arbor, Michigan, United States.

Rationale: There is an unmet need to investigate the lower airways in chronic obstructive pulmonary disease (COPD) to define pathogenesis and to identify potential markers to accelerate therapeutic development. Although bronchoscopy is well-established to sample airways in various conditions, a comprehensive COPD research protocol is not currently published.

Objectives: To evaluate the safety and tolerability of a comprehensive research bronchoscopy procedure suitable for multicenter trials and to identify factors associated with adverse events. Read More

J Eur Acad Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Saint-Louis Hospital, APHP, Paris Diderot University, INSERM U976, Paris, France.

Mycosis fungoides (MF), the most frequent type of cutaneous T-cell lymphoma, is characterized in the early stage by patches and plaques that predominate in sun-protected areas. MF is rarely associated with vulvar involvement. We report two cases of MF with predominant vulvar lesions. Read More

Am J Trop Med Hyg 2019 Jan 14. Epub 2019 Jan 14.

School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.

The pig is the natural intermediate host of , a parasite causing significant burden of disease in both humans and pigs. Porcine cysticercosis is traditionally detected via tongue palpation and slaughterhouse meat inspection, both with limited sensitivity. Serum antibody detection has a better performance; however, it does not discriminate past from present infection. Read More

Head Neck 2019 Jan 16. Epub 2019 Jan 16.

Department of Otolaryngology - Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.

Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer.

Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012.

Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2. Read More

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):318-324

General Dental Practitioner, Ferozepur, Punjab, India.

Introduction: Human papilloma virus (HPV)-associated oral squamous cell carcinoma (OSCC) shows different biological behavior as compared to tobacco-induced OSCC. Mere presence of HPV in OSCC is of no clinical significance; however, the integration of HPV-DNA through E6/E7 gene into the host genome is important as it affects the development and progression of OSCC.

Aim: The aim of this study was to determine the presence of E6/E7 proteins of high-risk (HR) HPV (HPV16 and HPV18) in saliva as well as lesional tissue of OSCC patients and to determine the use of saliva as an alternative to tissue for E6 and E7 proteins in OSCC. Read More

Oral Radiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Dentistry, Oral and Maxillofacial-Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.

Osseous choristoma is a rare entity in the oral and maxillofacial region. The most common site is the tongue, followed by the buccal mucosa. Osseous choristoma of the muscle is unusual and few cases have been described in the literature. Read More

Neuroradiol J 2019 Jan 16:1971400918825485. Epub 2019 Jan 16.

2 Department of Radiology, University of Pennsylvania Health System, USA.

Spontaneous internal carotid artery dissection occurs in patients of all ages, rarely presenting with hypoglossal nerve palsy. The characteristic imaging findings of internal carotid artery dissection and tongue denervation are reviewed in four patients. Recognition of internal carotid artery dissection is critical for appropriate treatment and to minimise the risk of thromboembolic-ischaemic complications. Read More

Dent Med Probl 2018 Oct-Dec;55(4):405-410

Department of Periodontology, Faculty of Dentistry, Wroclaw Medical University, Poland.

Background: The morbidity of certain oral pathologies, for example denture-related stomatitis, burning mouth syndrome (BMS) and benign neoplasms is higher in the elderly. It is necessary to periodically assess the changes in the profile of the occurrence of these diseases and determine the dominant risk factors associated with their incidence.

Objectives: The aim of the study was to evaluate the prevalence of oral mucosal pathologies (in particular, potentially malignant and cancerous disorders) in a randomly selected population of 65-74-year-old residents of Wrocław and Oława, Poland. Read More

J Magn Reson Imaging 2019 Jan 16. Epub 2019 Jan 16.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Background: Surgical resection of tongue cancer may impair swallowing and speech. Knowledge of tongue muscle architecture affected by the resection could aid in patient counseling. Diffusion tensor imaging (DTI) enables reconstructions of muscle architecture in vivo. Read More

Microsurgery 2019 Jan 15. Epub 2019 Jan 15.

Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: With the rising number of patients in advanced age receiving microsurgical procedures, coronary artery disease (CAD) and its challenging management is of increasing importance. Evidence based data concerning morbidity and mortality are rare. We present our experiences with this highly selected patient population and propose a preoperative assessment algorithm. Read More

Cureus 2018 Oct 29;10(10):e3508. Epub 2018 Oct 29.

Neurology, University of Missouri, Columbia, USA.

Movement disorders are rarely reported in association with antiphospholipid syndrome (APS). Although it is a rare manifestation in APS, chorea is the most common movement disorder. We report a case of APS in a patient who presented with hyperkinesia, tics, choreiform movements, and other dyskinetic movements involving the mouth and tongue along with behavioral changes. Read More

Case Rep Hematol 2018 13;2018:6910624. Epub 2018 Dec 13.

Otorhinolaryngology Department, Avicenna Military Hospital, Marrakech, Morocco.

Multiple myeloma is a plasma cell dyscrasis characterized by mature B cells proliferation in the bone marrow. In rare cases, the disease can present as an extramedullary location, making diagnosis and management more challenging. Here, we describe a rare case of tongue extramedullary myeloma and discuss diagnostic, prognostic, and therapeutic issues. Read More

Case Rep Anesthesiol 2018 17;2018:4245809. Epub 2018 Dec 17.

Department of Anaesthesiology and Critical Care, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

A 79-year-old lady, who was taking warfarin, presented to the Emergency Department with a painless anterior neck swelling, which was associated with hoarseness of voice, odynophagia, and shortness of breath. She first noticed the swelling after she removed her dentures in the evening. On examination, she had an increased respiratory rate. Read More

Curr Health Sci J 2018 Jul-Sep;44(3):211-224. Epub 2018 Jul 15.

Department of Clinical Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Tongue squamous cell carcinoma is one of the most commonly diagnosed intraoral squamous cell carcinomas (25-40%), being considered an aggressive form of squamous cell carcinoma, as it is most commonly associated with lymph node metastases and the survival rate at five years is below 50%. In according with these data, we have proposed in this study to individualize an epidemiological and histopathological profile of the patients with such oral cancers, diagnosed and treated in the Oral and Maxillofacial Surgery Clinic and in the Otolaryngology Surgery Clinic of the Emergency Clinical County Hospital Craiova, between 2015-2017. The cases were histopathologically reassessed according to the latest WHO classification of head and neck tumors, the variables of interest being the age of the patients, the gender, the lesion topography, the histological subtype, the degree of tumor differentiation, the pTNM stage, the resection margin status and the Brandwein-Gensler prognostic score. Read More

Swiss Dent J 2019 Jan 16;2(2019). Epub 2019 Jan 16.

Department of Oral Surgery, University Center for Dental Medicine Basel, University of Basel

The anaerobic microenvironment of the grooved tongue surface provides optimal conditions for the survival of microorganisms. These microbes may promote caries, periodontitis marginalis, periimplantitis as well as halitosis. A new device, the TS1 tongue vacuum cleaner, is designed to remove bacterial biofilm from the tongue’s surface. Read More

Clin Otolaryngol 2019 Jan 15. Epub 2019 Jan 15.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

Objective: Various anatomical structures of upper airway and physical differences are known to be risk factors for obstructive sleep apnea (OSA). Torus mandibularis is a structure that can appear on the inside of the mandible. Therefore, it is possible for tori to influence airway volume by occupying the space for tongue, and cause sleep apnea. Read More

Logoped Phoniatr Vocol 2019 Jan 15:1-7. Epub 2019 Jan 15.

c Department of Epidemiology and Biostatistics, Faculty of Health, Health promotion research center , Zahedan University of Medical Sciences , Zahedan , Iran.

Purpose: Hearing-impaired (HI) speakers show changes in vowel production and formant frequencies, as well as more cases of overlapping between vowels and more restricted formant space, than hearing speakers. This study was intended to explore whether the use of different acoustic parameters (Formant Centralization Ratio (FCR), Vowel Space Area (VSA), F2i/F2u ratio (second formant of/i,u/)) was suitable or not for characterizing impairments in the articulation of vowels in the speech of HL speakers. In fact, correlated acoustic parameters are used to determine the limits of tongue movements in vowel production in different severity degrees of hearing impairment. Read More

Tremor Other Hyperkinet Mov (N Y) 2018 8;8:610. Epub 2019 Jan 8.

Department of Neurology, Govind Ballabh Pant Postgraduate Institute of Medical Education and Research, New Delhi, IN.

Background: Lingual dystonia is extremely rare following stroke. We describe clinical features and neuroimaging findings in a series of 11 patients (seven acute and four chronic) with post-stroke lingual dystonia and review the literature.

Methods: This was a case series using a preformed structured proforma and review of literature using a PubMed search. Read More

Onco Targets Ther 2019 27;12:257-267. Epub 2018 Dec 27.

Department of Periodontology, School of Stomatology, Lanzhou University, Lanzhou, Gansu, China,

Objective: The aim of this study was to investigate whether evodiamine (EVO) could potentiate the antitumor activity of gemcitabine (GEM) in tongue cancer cells and determine its potential underlying mechanisms.

Materials And Methods: Human Tca8113 and CAL-27 tongue squamous carcinoma cell lines were treated with EVO and GEM in different sequences and doses, after which cell proliferation was measured. Drug interactions were analyzed using the Chou-Talalay method with CompuSyn software. Read More

Tohoku J Exp Med 2019 01;247(1):19-25

Department of Otorhinolaryngology, Nagoya City University.

Patients with laryngopharyngeal reflux (LPR) were reported to suffer from hypogeusia that affects quality of life. Proton pump inhibitor (PPI) is a useful drug in the treatment of LPR, but its effect on hypogeusia is not known. We therefore assessed the effects of PPI or a histamine H2 receptor antagonist (H2 blocker) on hypogeusia among patients with LPR. Read More

J Oral Maxillofac Surg 2018 Dec 18. Epub 2018 Dec 18.

Medical Director, Department of Craniofacial Surgery and Research Centre, SDM College of Medical Sciences, Dharwad, Karnataka, India.

Purpose: In the present study, we have highlighted the occurrence of different palatal fistulas and evaluated the difficulty level in planning the treatment, thereby enabling the prediction of the prognosis preoperatively.

Materials And Methods: The present retrospective study included 62 nonsyndromic cases with primary surgery and palatal fistula repair performed in our unit. Data were collected on the fistula incidence, site, and size, cleft type, fistula closure method. Read More

J Craniomaxillofac Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China. Electronic address:

Objective: To explore the application of modified resection compared with traditional segmental resection of the mandible for patients with anterior floor of the mouth and tongue squamous cell carcinoma (SCC) without infiltration of the mandible.

Subjects And Methods: This is a retrospective study including 36 eligible patients with anterior floor of the mouth SCC(9 patients received modified mandibulectomy, and 27 patients received segmental mandibulectomy).

Results: No patients in the modified mandibulectomy group developed recurrence in the floor of the mouth, and all of the patients survived. Read More

J Prosthet Dent 2019 Jan 9. Epub 2019 Jan 9.

Professor, Department of Maxillofacial Prosthetics, Graduate school of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Statement Of Problem: A palatogram aids prosthodontists and speech pathologists in evaluating the precise prosthetic treatment needed and the effectiveness of such treatment to improve speech intelligibility. Powder is commonly used to visualize tongue-palate contact, where wetted areas of powder in the oral cavity reveal such contact during palatography. However, discomfort and the risk of aspiration are among the shortcomings of this method, and an improved method is needed. Read More

Elife 2019 Jan 14;8. Epub 2019 Jan 14.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.

Development of vertebrate jaws involves patterning neural crest-derived mesenchyme cells into distinct subpopulations along the proximal-distal and oral-aboral axes. Although the molecular mechanisms patterning the proximal-distal axis have been well studied, little is known regarding the mechanisms patterning the oral-aboral axis. Using unbiased single-cell RNA-seq analysis followed by analysis of gene expression profiles, we show that Shh and Bmp4 signaling pathways are activated in a complementary pattern along the oral-aboral axis in mouse embryonic mandibular arch. Read More

J Dent Anesth Pain Med 2018 Dec 28;18(6):361-365. Epub 2018 Dec 28.

Department of Oral Health Sciences, KU Leuven, Belgium.

Background: Recently, we examined the effects of 2% lidocaine gel on the tactile sensory and pain thresholds of the face, tongue and hands of symptom-free individuals using quantitative sensory testing (QST); its effect was less on the skin of the face and hands than on the tongue. Consequently, instead of 2% lidocaine gel, we examined the effect of 8% lidocaine spray on the tactile sensory and pain thresholds of the skin of the face and hands of healthy volunteers.

Methods: Using Semmes-Weinstein monofilaments, QST of the skin of the cheek and palm (thenar skin) was performed in 20 healthy volunteers. Read More

Mov Disord Clin Pract 2018 Nov-Dec;5(6):661-662. Epub 2018 Oct 1.

Department of Neurology Mater Misericordiae University Hospital Eccles Street, Dublin 7 Ireland.

Pan Afr Med J 2018 30;30:298. Epub 2018 Aug 30.

Department of Otorhinolaryngology, Head and Neck Surgery, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin 12200, Germany.

J Cell Biochem 2019 Jan 11. Epub 2019 Jan 11.

Department of Oral and Maxillofacial Surgery, The Affiliated Zhongshan Hospital, Sun Yat-sen University, Zhongshan, China.

Tongue cancer remains a massive threat to public health due to the high rate of metastasis. Tumor cell epithelial-mesenchymal transition (EMT), which can be induced by transforming growth factor β1 (TGFβ1), has been regarded as a significant contributor to cancer invasion and migration. In our previous study, long noncoding RNA (lncRNA) MALAT1/miR-124/JAG1 axis modulates the growth of tongue cancer. Read More

Muscle Nerve 2019 Jan 12. Epub 2019 Jan 12.

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.

Vet Rec 2019 Jan 11. Epub 2019 Jan 11.

Epidemiology Research Unit, Scotland's Rural College, Edinburgh, UK.

The capability to set baselines and monitor trends of health and welfare conditions is an important requirement for livestock industries in order to maintain economic competitiveness and sustainability. Monitoring schemes evaluate the relative importance of conditions so that: appropriate actions can be determined, prioritised and implemented; new and (re)emerging conditions can be promptly detected and the effectiveness of any actions can be measured. In 2011, the national pig levy board published a strategy document highlighting health and welfare conditions of importance to the pig industry that were to be targeted for control. Read More

World J Surg Oncol 2019 Jan 11;17(1):15. Epub 2019 Jan 11.

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala, 670 103, India.

Background: Oral cancer is very common in India. The reported 5-year survival of such patients is around 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries.

Methods: A retrospective study of a prospective database of oral cancer patients undergoing surgery from June 2009 to June 2013 was conducted. Read More

BMC Med Genet 2019 Jan 11;20(1):12. Epub 2019 Jan 11.

Division of Plastic Surgery, King Saud University, PO Box 18097, Riyadh, 11415, Saudi Arabia.

Background: Rubinstein-Taybi syndrome (RSTS) Type 1 (OMIM 180849) is characterized by three main features: intellectual disability; broad and frequently angulated thumbs and halluces; and characteristic facial dysmorphism.

Case Presentation: We report on a Saudi boy with RSTS Type 1 and the following distinct features: a midline notch of the upper lip, a bifid tip of the tongue, a midline groove of the lower lip, plump fingers with broad / flat fingertips, and brachydactyly. The child was found to be heterozygous in the CREBBP gene for a sequence variant designated c. Read More

Exp Gerontol 2019 Jan 8;118:45-50. Epub 2019 Jan 8.

Division of Otolaryngology-Head and Neck Cancer, Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America; Department of Biomedical Engineering, University of Wisconsin-Madison, United States of America; Department of Communication Sciences and Disorders, University of Wisconsin-Madison, United States of America.

Background: Aging rodent models allow for the discovery of underlying mechanisms of cranial muscle dysfunction. Methods are needed to allow quantification of complex, multivariate biomechanical movements during swallowing. Videofluoroscopic swallow studies (VSS) are the standard of care in assessment of swallowing disorders in patients and validated quantitative, kinematic, and morphometric analysis methods have been developed. Read More

Head Neck 2019 Jan 11. Epub 2019 Jan 11.

Vanderbilt University Medical Center, Department of Otolaryngology, Nashville, Tennessee, USA.

Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown.

Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Read More

Head Neck 2019 Jan 11. Epub 2019 Jan 11.

Department of Head and Neck Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.

Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown.

Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC.

Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Read More

Ann Plast Surg 2019 Jan 9. Epub 2019 Jan 9.

Department of Plastic Surgery, University of São Paulo, São Paulo, Brazil.

Background: Crouzon syndrome is associated with severe respiratory impairment of the upper airway due in part to midfacial dysmorphology. We calculated the distinctive nasal diameter and pharyngeal airway volume in patients with Crouzon syndrome and compared them with age-matched control subjects.

Methods: Children with computed tomography scans in the absence of surgical intervention were included. Read More

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):603-604

Cardiology Department, Chippenham Hospital, Richmond VA, USA.

Angioedema is a life-threatening reaction characterized by swelling of the face, lips, tongue or larynx. Known adverse effects of Pitavastatin do not include angioedema. We report first case of a 55-year-old Asian male developing post exposure angioedema to 2 mg Pitavastatin. Read More

PLoS One 2019 10;14(1):e0210527. Epub 2019 Jan 10.

Department of Oral Medicine and Periodontology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.

Objectives: The aim of this cross-sectional observational study was to compare the prevalence of different oral Candida spp. in patients with Type 2 Diabetes and chronic periodontitis in two oral sites: dorsal surface of the tongue and subgingival area. In order to determine subgingival areas as potential reservoirs of yeasts, this study aimed to find differences in the yeasts' detection between the dorsum of the tongue, as the oral site most commonly inhabited with microorganisms, and subgingival samples. Read More

Mol Med Rep 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiovascular Intervention, Affiliated Hospital of Inner Mongolia University for The Nationalities, Tongliao, Inner Mongolia 028000, P.R. China.

Numerous microRNAs (miRNAs) are dysregulated in tongue squamous cell carcinoma (TSCC), and their dysregulation has been demonstrated to have a strong correlation with TSCC progression via regulation of their targets. Therefore, miRNAs have potential use in the diagnosis and treatment of patients with TSCC. In the present study, miRNA‑758 (miR‑758) expression in TSCC tissues and cell lines was detected through reverse transcription‑quantitative polymerase chain reaction, and the effects of miR‑758 on TSCC cell proliferation and invasion were investigated by using Cell Counting kit‑8 and Transwell invasion assays. Read More