25,872 results match your criteria Toenails Ingrown


Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.

Apoptosis 2018 Dec 14. Epub 2018 Dec 14.

Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.

Epidermal keratinocytes undergo cornification to form the cellular building blocks of hard skin appendages such as nails and the protective layer on the surface of the skin. Cornification requires the cross-linking of structural proteins and the removal of other cellular components to form mechanically rigid and inert corneocytes. Autophagy has been proposed to contribute to this intracellular remodelling process, but its molecular targets in keratinocytes, if any, have remained elusive. Read More

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December 2018
1 Read

Implant-related sepsis in lower limb fractures following gunshot injuries in the civilian population: A systematic review.

Injury 2018 Dec 5. Epub 2018 Dec 5.

Division of Orthopaedics, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; Countess of Chester Hospital, Chester, UK.

Introduction: The management of long bone lower limb fractures secondary to gunshot wounds (GSWs) in the civilian setting are complex and there is currently no consensus regarding the optimal approach to managing such fractures. This study aims to address the relationship of implant related sepsis in fractures secondary to GSWs.

Methods: A systematic review of the literature was performed on both Pubmed and Scopus databases that look at fractures caused by GSWs in the lower limb. Read More

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December 2018

Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.

Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low permeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of penetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail pathologies. Read More

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December 2018

Whole exome sequencing identified two point mutations of COL7A1 and FLG in a Chinese family with dystrophic epidermolysis bullous pruriginosa and ichthyosis vulgaris.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.

We report a 21-year-old man with recurrent bullous eruptions and severe itching on the lower legs and feet since 5 years of age. Dry, dirty brown, tile-like scales covered his lower legs with dystrophic toenails. Nodular prurigo-like lesions, scarring papules and milia remitted after the bullous eruptions. Read More

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December 2018

PTP1B markedly promotes breast cancer progression and is regulated by miR-193a-3p.

FEBS J 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing University, 163 Xianlin Road, Nanjing, Jiangsu, 210023, China.

The protein tyrosine phosphatase PTP1B, which is encoded by PTPN1, is a ubiquitously expressed non-receptor protein tyrosine phosphatase. PTP1B has long been known to negatively regulate insulin and leptin receptor signalling. Recently, it was reported to be aberrantly expressed in cancer cells and to function as an important oncogene. Read More

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December 2018

High-Frequency Heating Extraction Method for Sensitive Drug Analysis in Human Nails.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Department of Legal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

A simple, sensitive, and rapid extraction method based on high-frequency (H-F) heating was developed for drug analysis in human nails. A human nail was placed in a glass tube with an extraction solvent (methanol and 0.1% formic acid; 7:3, /), and a ferromagnetic alloy (pyrofoil) was wrapped in a spiral around the glass tube. Read More

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December 2018

Targeted next-generation sequencing identifies a novel mutation of LAMB3 in a Chinese neonatal patient presented with junctional epidermolysis bullosa.

Medicine (Baltimore) 2018 Dec;97(49):e13225

Department of Obstetrics and Gynecology, Wuhan Medical & Health Center for Women and Children, Wuhan, Hubei.

Rationale: Epidermolysis bullosa (EB) refers to a group of rare inherited mechanobullous disorders that present with great clinical and genetic heterogeneity. Its severity ranges from mild blistering to life-threatening. However, the clinical symptoms of different types of EB overlap significantly, especially at an early stage. Read More

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December 2018

Quantification of fetal steroids in nails of neonates to quantify prenatal stress and growth restriction.

Biol Psychol 2018 Dec 10;140:81-85. Epub 2018 Dec 10.

General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich-Heine-University, Moorenstraße 5, 40225, Düsseldorf, Germany. Electronic address:

This study assesses the impact of prenatal stress and intrauterine growth restriction (IUGR) on the dehydroepiandrosterone (DHEA) and dehydroepiandrosteronesulfate (DHEAS) concentrations in nails of newborns. Nail samples were gained from 56 newborn infants. The concentration of DHEA and DHEAS was measured by liquid chromatography/tandem mass spectrometry. Read More

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December 2018

Single-Incision Double-Plating Approach in the Management of Isolated, Closed Osteoporotic Distal Femoral Fractures.

Geriatr Orthop Surg Rehabil 2018 11;9:2151459318799856. Epub 2018 Nov 11.

Ain-Shams University, Cairo, Egypt.

Introduction: Distal femoral fractures in elderly population had recorded an increase in incidence in the last 2 decades. Lateral distal femoral locking plating is considered one of the best options especially when dealing with comminuted fractures but varus collapse of the medial femoral condyle occurs frequently in patients with osteoporosis. Anatomical reduction of the fracture with stable rigid fixation using double-plating approach allows early mobilization of geriatric population and prevents varus collapse minimizing the comorbidities in such fractures. Read More

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November 2018

Numerical Simulation of an Intramedullary Elastic Nail: Expansion Phase and Load-Bearing Behavior.

Front Bioeng Biotechnol 2018 21;6:174. Epub 2018 Nov 21.

Department of Engineering, University of Perugia, Perugia, Italy.

The Marchetti-Vicenzi's nail is an intramedullary device where six curved nails are kept straight by a closing ring in order to allow their insertion into the medullary canal of a long bone; in a following step, these nails stabilize the fracture due to the ring withdrawal and to the consequent elastic expansion of the nails. Pre-clinical testing of this sort of device is strongly advocated in order to be able to foresee their stability inside the medullary canal and to quantify their stiffening action on a broken bone. In this numerical work, an MB (Multi Body) model of the device has been developed, with the dual purpose of evaluating forces between the bone and the system components during its progressive opening and verifying the behavior of the stabilized bone when it undergoes external loading. Read More

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November 2018

Flexible intramedullary nails for limb lengthening: a comprehensive comparative study of three nails types.

Biomed Mater 2018 Dec 4. Epub 2018 Dec 4.

Rossijskij nauchnyj tsentr Vosstanovitel'naja travmatologija I ortopedija imeni akademika G A Ilizarova, Kurgan, RUSSIAN FEDERATION.

This study aims to investigate the comparative study of calcium phosphate coatings for flexible intramedullary nails (FINs) used to lengthen long tubular bones. The presence of a calcium phosphate coating deposited by micro-arc oxidation or a composite coating based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) on the surface of the FIN significantly enhanced the regeneration of bone in the area of osteotomy during limb lengthening by combined osteosynthesis. The investigation of the physicochemical properties of the FIN coated with calcium phosphate via micro-arc oxidation demonstrated that the improved bone tissue formation resulted from favorable conditions for adhesion, proliferation, and differentiation of multipotent stem cells into osteoblasts on the coating surface. Read More

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December 2018

Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

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December 2018
2 Reads

Biomechanics of Femoral Neck Fractures and Implications for Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S27-S32

*Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany; and †Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria.

Fractures of the femoral neck can occur in young healthy individuals due to high loads occurring during motor vehicle accidents, impacts, or falls. Failure forces are lower if impacts occur sideways onto the greater trochanter as compared with vertical loading of the hip. Bone density, bone geometry, and thickness of cortical bone at the femoral neck contribute to its mechanical strength. Read More

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January 2019
3 Reads

A Quartet of Elastic Stable Intramedullary Nails for More Challenging Pediatric Femur Fractures.

J Pediatr Orthop 2019 Jan;39(1):e12-e17

Children's Healthcare of Atlanta.

Introduction: The insertion of 2 elastic stable intramedullary nails (ESINs) is a common treatment for pediatric femur fractures. However, the use of this technique in length-unstable or metadiaphyseal fractures has historically been associated with higher complication rates. To improve stability, the addition of a third ESIN has been assessed biomechanically and clinically, but the addition of a fourth nail has only been evaluated biomechanically. Read More

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January 2019

The genetic profile of bone marrow transplant patients in different samples of forensic interest.

Forensic Sci Med Pathol 2018 Dec 10. Epub 2018 Dec 10.

Unit of Legal Medicine, Department of Physiology and Pharmacology, University of Cantabria, Av Cardenal Herrera Oria s/n, 39011, Santander, Spain.

Humans constantly lose epithelial cells, and these biological traces are frequently studied in the context of criminal investigations. The objective of this work was to examine the genetic profile in samples of forensic interest (nail and skin epithelial cells) of bone marrow transplant patients and discuss its forensic and clinical implications. The genetic profile of nail, epidermal cells and blood samples of patients receiving HSCT was analyzed by the amplification and sequencing of 38 insertion/deletion polymorphisms and 15 short tandem repeat polymorphisms. Read More

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December 2018
2 Reads

To what extend is nail ultrasound discriminative between psoriasis, psoriatic arthritis and healthy subjects?

Rheumatol Int 2018 Dec 10. Epub 2018 Dec 10.

Department of Social Psychology and Methodology, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Spain.

To assess the discriminative utility of nail features detected by B-mode (BM) and color Doppler (CD) ultrasound (US) between patients with psoriasis (PsO) and psoriatic arthritis (PsA) and healthy controls. Sixty patients with PsA, 21 patients with PsO, and 20 healthy controls were prospectively included. All patients underwent a dermatologic assessment and PsA patients also a rheumatologic assessment. Read More

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December 2018

[Frequency of Epidermophyton floccosum in isolated dermatophytea laboratory from the Region of Valparaiso, Chile. Time frame: 1990-2010].

Rev Chilena Infectol 2018 ;35(3):262-265

Laboratorio de Micología, Universidad de Valparaíso, Valparaíso, Chile.

Background: Dermatophytoses are frequent infections in human, which are produced by fungus genera Trichophyton, Microsporum and Epidermophyton.

Aim: To determine frequency of E. floccosum in isolated dermatophyte in a laboratory from Valparaíso during the last three decades, in addition to knowing the most frequent localization, age and gender of patients affected by this agent. Read More

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January 2018

A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light.

Bioact Mater 2019 Mar 23;4(1):17-21. Epub 2018 Nov 23.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.

Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment . Thus, the development of novel implant materials is quite urgent. Read More

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Intramedullary nails with cannulated screw fixation for the treatment of unstable femoral neck fractures.

J Int Med Res 2018 Dec 11:300060518816185. Epub 2018 Dec 11.

1 Department of Orthopaedic Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, PR China.

Objective: Unstable femoral neck fractures are typically high-angled shear fractures caused by high-energy trauma. Internal fixation of femoral neck fractures with placement of parallel cannulated screws in an inverted triangle configuration is commonly performed in the clinical setting. This study was performed to investigate the primary results of intramedullary nailing with cannulated screws for the treatment of unstable femoral neck fractures in young and middle-aged patients. Read More

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December 2018

[Functional results and complications of the use of the proximal femoral nail in the treatment of intertrochanteric hip fractures].

Acta Ortop Mex 2018 May-Jun;32(3):126-130

Centro de Evaluación de Tecnologías, Universidad CES, Medellín, Colombia.

Introduction: Cephalomedullary nails are used for the treatment of hip fractures; however, there are few studies that allow identifying data on the complications of the use of these devices and the results in terms of restoration of the functionality of the patient.

Methods: A cross-sectional study of patients with femur fracture was conducted during the period from January 2008 to December 2012. Data on demographic and clinical variables were collected. Read More

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December 2018
2 Reads

Nail Psoriasis: An Updated Review and Expert Opinion on Available Treatments, Including Biologics.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 1, IT-40138 Bologna, Italy.

Nail psoriasis affects 50-79% of patients with skin psoriasis and up to 80% of patients with psoriatic arthritis, and can also represent a negative prognostic factor in individuals with plaque psoriasis. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies alone, and relapse is common. Among different systemic agents, secukinumab, a fully human monoclonal antibody targeting interleukin (IL)-17A, is the only antibody supported by a trial specifically conducted in patients with nail psoriasis (the TRANSFIGURE trial) and has the longest follow-up available to date. Read More

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December 2018
5 Reads

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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December 2018
4 Reads

Debridement, internal fixation and staged autogenous bone graft for the management of infected femoral non-union.

Injury 2018 Dec 3;49 Suppl 4:S48-S57. Epub 2018 Dec 3.

Hip Department - Orthopedic and Trauma v, I.R.C.C.S. Policlinico San Donato, 20097, San Donato Mil.se, Milan, Italy; Division of Orthopaedic Surgery, McMaster University, Canada.

An infected non-union is a major and potentially devastating complication following bone fractures. It is often debilitating for the patients, physically and psychologically, because of its long healing period and emotional toll on patient and caregivers. Different surgical procedures (in one or two stages) are described in literature for its treatment. Read More

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December 2018
1 Read

Total knee arthroplasty in a patient with nail-patella syndrome (NPS).

Knee 2018 Nov 29. Epub 2018 Nov 29.

Houston Methodist Othopedics & Sports Medicine, Houston, TX, United States of America. Electronic address:

Nail-patella syndrome (NPS) or hereditary onycho-osteodyaplasia is a rare genetic condition involving a mutation in the LMX1B gene affecting nails, elbows, knees, and pelvis. Due to the regulatory functions of the gene in many developmental processes through the body, patients with NPS experience wide-ranging musculoskeletal problems including patellar instability, fingernail anomalies, iliac exostoses/horns, and elbow abnormalities. The patellar changes often involve aplasia, hypoplasia, and chronic dislocation. Read More

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November 2018
4 Reads

Influence of Fluoridated Groundwater and 1,100 Ppm Fluoride Dentifrice on Biomarkers of Exposure to Fluoride.

Braz Dent J 2018 Sep-Oct;29(5):475-482

Department of Public Health and Clinic Dentistry, Health Sciences Center, UFPB - Universidade Federal da Paraiba, João Pessoa, PB, Brazil.

This research aimed to determine the influence of fluoridated groundwater and 1,100 ppm fluoride dentifrice on biomarkers of exposure to fluoride in preschoolers. A cross-sectional study was performed on thirty preschoolers recruited from naturally fluoridated and non-fluoridated areas (n=15). Total Daily Fluoride Intake (TDFI) from diet and dentifrice, and Daily Urinary Fluoride Excretion (DUFE) was measured over 24 h. Read More

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January 2018

Thick nails, plantar keratoderma, follicular hyperkeratosis, and leukokeratosis associated with a novel mutation in KRT6A gene.

Int J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense, Madrid, Spain.

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December 2018

Microbial Keratinases: Enzymes with Promising Biotechnological Applications.

Food Technol Biotechnol 2018 Sep;56(3):312-328

Chair of Microbiology and Microbial Biotechnology, Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 
SI-1230 Domžale, Slovenia.

Keratin is a complex and structurally stable protein found in human and animal hard tissues, such as feathers, wool, hair, hoof and nails. Some of these, like feathers and wool, represent one of the main sources of protein-rich waste with significant potential to be transformed into value-added products such as feed, fertilizers or bioenergy. A major limitation impeding valorization of keratinous substrates is their recalcitrant structure and resistance to hydrolysis by common proteases. Read More

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September 2018

Evaluation of the bacterial burden of gel nails, standard nail polish, and natural nails on the hands of health care workers.

Am J Infect Control 2018 Dec 6;46(12):1356-1359. Epub 2018 Jul 6.

College of Graduate Nursing, Western University, Pomona, CA.

Background: Acrylic nails harbor more bacteria than natural nails, and wear is not recommended for health care workers (HCWs). Little is known about the new and popular gel nail products. This study sought to evaluate the bacterial burden of gel nails, standard nail polish, and natural nails on the hands of HCWs. Read More

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December 2018

Bacterial and Parasitic Assessment from Fingernails in Debre Markos, Northwest Ethiopia.

Can J Infect Dis Med Microbiol 2018 18;2018:6532014. Epub 2018 Oct 18.

Department of Medical Laboratory Science, College of Medical and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Food handlers with untrimmed finger nails could contribute or serve as a vehicle for the transmission of food poisoning pathogens.

Objectives: This study was conducted to determine the prevalence of bacteria and intestinal parasites among food handlers and antibiotic susceptibility profile of the isolated bacteria in Debre Markos University, Ethiopia.

Materials And Methods: This laboratory-based cross-sectional study involved 220 food handlers working in food service establishments in Debre Markos University between 1st January 2015 to 31th June 2016. Read More

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October 2018
7 Reads

Dynamic Stress Fluoroscopy (DSF) For Evaluation of the Femoral Neck after Intramedullary Nails: Improved Sensitivity for Identifying Occult Fractures.

J Orthop Trauma 2018 Oct 8. Epub 2018 Oct 8.

Director of Orthopaedic Trauma Research, Level One Orthopaedics, Orlando Health Orthopaedic Institute, 1222 S Orange Avenue, MP 43, Orlando, Florida 32806, Orthopaedic Surgeon, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 Associate Professor and Residency Director, Director of Orthopaedic Trauma Research, University of South Florida, 5 Tampa General Circle, Suite 710, Tampa, FL 33606.

Objectives: To report on the use of dynamic stress fluoroscopy (DSF) for detection of occult fractures of the femoral neck associated with femoral shaft fractures. To compare DSF with a fully static imaging protocol in detecting occult femoral neck fractures.

Design: Multicenter retrospective cohort study SETTING:: Two urban level I trauma centers PARTICIPANTS/INTERVENTION:: A consecutive series of 1273 femoral shaft fractures were included. Read More

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October 2018

Overcoming Anterior Breaches in the Distal Femur During Long Gamma Nailing.

Orthopedics 2018 Nov 26:1-3. Epub 2018 Nov 26.

Anterior cortical penetration of distal femora when using long gamma nails is well established. To avoid this complication, using the appropriate entry point, a nail with a smaller radius of curvature, and intraoperative imaging is suggested. Despite this, there are times when the guidewire or the nail can abut or even perforate the anterior cortex. Read More

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November 2018

Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, University of California, Irvine.

Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4. Read More

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November 2018
4 Reads

Correlation over time of toenail metals among participants in the VA normative aging study from 1992 to 2014.

J Expo Sci Environ Epidemiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, 401 Park Drive, Landmark Center, L3-046, PO Box 15677, Boston, MA, 02215, USA.

Background: Scientists use biomarkers to evaluate metal exposures. One biomarker, toenails, is easily obtained and minimally invasive, but less commonly used as a biomarker of exposure. Their utility will depend on understanding characteristics of their variation in a population over time. Read More

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November 2018

Onychoscopy: an observational study in 237 patients from the Kashmir Valley of North India.

Dermatol Pract Concept 2018 Oct 31;8(4):283-291. Epub 2018 Oct 31.

Postgraduate Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, University of Kashmir, Jammu & Kashmir, India.

Background: Nail disorders comprise approximately 10% of all dermatological conditions. Because diagnosis is not always possible by clinical means alone, additional diagnostic procedures may be required at times. Dermoscopy of nails (onychoscopy) has shown promising results in diagnosing various nail disorders and also avoids time-consuming investigations such as culture and biopsy. Read More

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October 2018
2 Reads

[Trisomy 9p and clinical heterogeneity: case report of an unusual presentation].

Orv Hetil 2018 Nov;159(47):1994-2000

II. Gyermekgyógyászati Klinika, Genetikai Részleg, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Pf. 2., 1428.

Whole or partial trisomy of the short arm of chromosome 9 (9p) is considered to be one of the more frequent chromosome abnormalities compatible with life. The duplication may affect various organs, however the most common symptoms are certain specific facial dysmorphisms and abnormalities of the fingers, toes and nails. A one month old boy presented with failure to thrive, jaundice, ventricular septal defect (VSD) and dysmorphic face. Read More

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November 2018
9 Reads

Onychoscopy of non-infectious nail abnormalities in patients after allogeneic haematopoietic stem cell transplantation.

J Eur Acad Dermatol Venereol 2018 Nov 23. Epub 2018 Nov 23.

Department of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie Institute- Oncology Centre, Gliwice Branch, Gliwice, Poland.

Nail abnormalities after allogeneic haematopoietic stem cell transplantation procedure (alloHSCT) are often reported. Usually, they are related to chronic graft-versus-host disease (cGvHD). So far, only clinical manifestations of selected nail abnormalities have been described, without the presentation of dermoscopic images. Read More

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November 2018
1 Read

All-endoscopic management of benign bone lesions; a case series of 26 cases with minimum of 2 years follow-up.

SICOT J 2018 22;4:50. Epub 2018 Nov 22.

Orthopedics & Trauma Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: Assessment of the functional and oncologic outcomes regarding endoscopic curettage of different benign bone tumor types within variable anatomic locations.

Patients And Methods: During the period between February 2012 and December 2016, 26 patients with symptomatic intra-osseous benign bony lesions were included. The age ranged from 3 up to 49 years (mean 20), of 14 females and 12 males. Read More

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November 2018
3 Reads

Retrograde dynamic locked intramedullary nailing for distal femoral aseptic nonunion associated with broken antegrade locked nail.

Authors:
Chi-Chuan Wu

Acta Orthop Belg 2018 Jun;84(2):132-140

Techniques for treating distal femoral aseptic nonunions associated with antegrade locked nail breakage are controversial. Each technique has unique advantages and disadvantages. Retrograde dynamic locked nailing was used in such treatment. Read More

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June 2018
4 Reads

Should antibiotic prophylaxis before orthopedic implant surgery depend on the duration of pre-surgical hospital stay?

Antimicrob Resist Infect Control 2018 8;7:131. Epub 2018 Nov 8.

3Infectiology, Balgrist University Hospital, Forchstrasse 340, 8008 Zürich, Switzerland.

Background: Prolonged hospital stay before surgery is a risk for colonization with antibiotic-resistant microorganisms and possible antibiotic-resistant surgical site infections (SSI), which lacks acknowledgement in international guidelines for perioperative antibiotic prophylaxis.

Method: Retrospective cohort study focusing on prophylaxis-resistant SSI in adult orthopedic implant patients; with emphasis on length of hospital stay prior to the index surgery.

Results: We enrolled 611 cases of SSI (median age, 65 years; 241 females and 161 immune-suppressed) in four large implant groups: arthroplasties ( = 309), plates ( = 127), spondylodeses ( = 31), and nails ( = 46). Read More

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November 2018
6 Reads

Toenail manganese as a potential biomarker for in utero and early childhood exposure studies.

Sci Rep 2018 Nov 19;8(1):17034. Epub 2018 Nov 19.

School of Public Health, Division of Environmental Health Sciences, University of Minnesota, Minneapolis, MN, 55455, USA.

Elevated in utero and early childhood exposure to manganese may have adverse effects on neurodevelopment. We conducted preliminary analyses to evaluate toenails as a matrix for investigating manganese exposure in infants. Infant and maternal toenail and hair samples were collected from 25 infants (7 months old) and their mothers. Read More

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November 2018
5 Reads

Retrograde Stainless Steel Flexible Nails Have Superior Resistance to Bending in Distal Third Femoral Shaft Fractures.

J Pediatr Orthop 2018 Nov 16. Epub 2018 Nov 16.

Texas Scottish Rite Hospital for Children, Dallas, TX.

Background: It has been shown that retrograde titanium flexible intramedullary nails (Ti FIN) provide superior resistance to bending compared to antegrade Ti FIN in distal femur fractures. The purpose of this study was to compare resistance to torsional and bending forces of stainless steel (SS) FIN, with or without a locking screw, and Ti FIN in distal third femoral shaft fractures. We hypothesize that locked retrograde SS FIN will demonstrate greater resistance to both bending and torsional forces. Read More

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November 2018

Is nail dynamization beneficial after twelve weeks - An analysis of 37 cases.

J Clin Orthop Trauma 2018 Oct-Dec;9(4):322-326. Epub 2017 Dec 22.

Department of Orthopaedic & Spine Surgery, Ganga Hospital, Mettupalayam Road, Coimbatore 641 011, India.

Purpose: Although nail dynamization in femoral and tibial fractures is an effective method of promoting healing, its role beyond twelve weeks is still not clear. It is usually done two to three months following interlocking nailing. This study was done to evaluate the efficacy of late dynamization (after 12 weeks) and factors affecting union. Read More

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December 2017
1 Read

Mobile Phone Reminders for Onychomycosis Medication Adherence.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Weill Cornell Medicine, Department of Dermatology, NY, NY. Electronic address:

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November 2018

Topology of Psoriasis in Routine Care - Results from a High-resolution Analysis in 2,009 Patients.

Br J Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.

Background: In psoriasis, a variety of different phenotypes have been described. However, little details are known about the topology in patients from routine care.

Objectives: To characterize the frequency and distribution of body sites affected by psoriasis in Germany based on high-resolution analysis. Read More

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November 2018
5 Reads

[Motorized intramedullary lengthening nails].

Unfallchirurg 2018 Nov;121(11):858-859

Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

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November 2018

[MagicTube: new possibilities for completely internal bone segmental transport and optional lengthening : New additional module for motorized lengthening nails for treatment of large bone defects].

Unfallchirurg 2018 Nov;121(11):884-892

Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Segmental bone transport is an effective method of treatment for segmental defects but the previous need for external fixation constructs during the transport phase is a great disadvantage, especially in the femur. In order to avoid external fixation, a new cylindrical combitube segmental transport (CKTST, MagicTube) module for combination with a commercially available motorized lengthening nail was developed by the author. This MagicTube module enables completely internal segmental bone transport and also enables optional lengthening if needed. Read More

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November 2018

Uniting the un-united: should established non-unions of femoral shaft fractures initially treated with IM nails be treated by plate augmentation instead of exchange IM nailing? A systematic review.

Strategies Trauma Limb Reconstr 2018 Nov 13;13(3):119-128. Epub 2018 Nov 13.

Trauma and Orthopaedic Unit, Aberdeen Royal Infirmary, Wards 212/213, Foresterhill, Aberdeen, AB25 2ZN, UK.

The majority of femoral fractures are surgically treated with intramedullary nails. Non-union rate is low but challenging and costly if it occurs. There have been encouraging results from the use of augmentative plating as a treatment for non-union of femoral fractures. Read More

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November 2018
3 Reads

Mutation in Phospholipase C, δ1 () Gene Underlies Hereditary Leukonychia in a Pashtun Family and Review of the Literature.

Balkan J Med Genet 2018 Jun 29;21(1):69-72. Epub 2018 Oct 29.

Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology (KUST), Kohat, Khyber Pakhtunkhwa, Pakistan.

Human hereditary leukonychia is a rare nail disorder characterized by nail plates whitening on all finger and toe nails. Inheritance pattern is both autosomal dominant and recessive. To date, the only gene, phospholipase C, δ1 (), on chromosome 3p22. Read More

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