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Clin Pharmacol Ther 2018 Nov 17. Epub 2018 Nov 17.

Department of Clinical Pharmacology, University Medicine of Greifswald, Greifswald, Germany.

Bioavailability of orally administered drugs is partly determined by function of drug transporters in the liver and intestine. Therefore, we explored adenosine triphosphate-binding cassette (ABC) and solute carriers family transporters expression (quantitative polymerase chain reaction) and protein abundance (liquid chromatography tandem mass spectrometry (LC-MS/MS)) in human liver and duodenum, jejunum, ileum, and colon in paired tissue specimens from nine organ donors. The transporter proteins were detected in the liver (permeability-glycoprotein (P-gp), multidrug resistance protein (MRP)2, MRP3, breast cancer resistance protein (BCRP), organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP2B1, organic cation transporter (OCT)1, OCT3, organic anion transporter 2, Na+-taurocholate cotransporting polypeptide, monocarboxylate transporter (MCT)1, and multidrug and toxin extrusion 1) and the intestine (P-gp, multidrug-resistance protein (MRP)2, MRP3, MRP4, BCRP, OATP2B1, OCT1, apical sodium-bile acid transporter (only ileum), MCT1, and peptide transporter (PEPT1)). Read More

BMC Res Notes 2018 Oct 11;11(1):719. Epub 2018 Oct 11.

Department of Physiology, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173, Hannover, Germany.

Objective: Chloride (Cl) secretion is crucial for intestinal fluid secretion. Therefore, effects of the polyphenol Resveratrol (RSV) on Cl secretion have been investigated. In a previous study, we observed effects of RSV on forskolin-induced Cl secretion in the porcine jejunum but not the ileum although RSV itself induced a transepithelial ion current that may represent Cl secretion in the ileum. Read More

Head Neck 2018 Oct 13;40(10):2210-2218. Epub 2018 May 13.

Department of Head and Neck Surgery, Osaka Prefectural Hospital Organization, Osaka International Cancer Institute, Osaka, Japan.

Background: In pharyngoesophageal reconstruction, we transferred a long jejunum flap containing multiple pedicles to achieve a 100% flap survival rate, and used the redundant mesentery to cover important tissues and fill in the dead space to reduce common postoperative complications, such as surgical site infections and fistula formation.

Methods: A total of 243 jejunal flap transfers with multiple vascular anastomoses were reviewed to examine flap survival and rates of early postoperative complications, such as surgical site infections and fistula formation, perioperative mortality, and donor site morbidity.

Results: All 243 jejunal flaps survived without any partial necrosis. Read More

Biochim Biophys Acta Mol Basis Dis 2018 06 28;1864(6 Pt A):2131-2142. Epub 2018 Mar 28.

Avantea, Laboratory of Reproductive Technologies, Via Porcellasco 7/f, Cremona 26100, Italy; Dept. of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia, BO, Italy. Electronic address:

Leigh syndrome (LS) associated with cytochrome c oxidase (COX) deficiency is an early onset, fatal mitochondrial encephalopathy, leading to multiple neurological failure and eventually death, usually in the first decade of life. Mutations in SURF1, a nuclear gene encoding a mitochondrial protein involved in COX assembly, are among the most common causes of LS. LS patients display severe, isolated COX deficiency in all tissues, including cultured fibroblasts and skeletal muscle. Read More

Plast Reconstr Surg 2018 03;141(3):468e-469e

Department of Plastic Surgery Department of Thoracic and Cardiovascular Surgery Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

J Dairy Sci 2018 Apr 4;101(4):3099-3109. Epub 2018 Feb 4.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5. Electronic address:

The objective of this study was to investigate the effect of time of first colostrum feeding on the passive transfer of IgG and on bacterial colonization in the intestine of neonatal dairy calves. Twenty-seven male Holstein calves were randomly assigned to 1 of 3 treatments at birth: calves were fed colostrum at 45 min (0 h, n = 9), 6 h (n = 9), or 12 h after birth (n = 9). Calves were fed pooled, heat-treated colostrum (62 g of IgG/L) at their respective feeding times at 7. Read More

Toxins (Basel) 2018 01 18;10(1). Epub 2018 Jan 18.

Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

The mycotoxin enniatin B (ENN B) is a so-called emerging mycotoxin frequently contaminating poultry feed. To investigate the impact of chronic ENN B exposure on animal health, broiler chickens were fed either a diet naturally contaminated with ENN B (2352 µg/kg) or a control diet (135 µg/kg) for 2, 7, 14, or 21 days. ENN B concentrations were determined in plasma and liver using a validated ultra-high performance liquid chromatography-tandem mass spectrometry UHPLC-MS/MS method. Read More

Sci Rep 2017 Nov 6;7(1):14514. Epub 2017 Nov 6.

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Claudins are key functional and structural components of tight junctions (TJs) in epithelial cell sheets. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds to claudin-4 and reversibly modulates intestinal TJ seals, thereby enhancing paracellular transport of solutes. However, the use of C-CPE as an absorption enhancer is limited by the molecule's immunogenicity and manufacturing cost. Read More

J Am Coll Surg 2017 Nov 14;225(5):650-657. Epub 2017 Aug 14.

Department of Plastic Surgery, The Ohio State University, Columbus, OH. Electronic address:

Background: Vascularized lymph node transfer (VLNT) is a surgical treatment for lymphedema. Multiple donor sites have been described and each has significant disadvantages. We propose the jejunal mesentery as a novel donor site for VLNT. Read More

Oral Oncol 2017 09 15;72:194-196. Epub 2017 Jul 15.

Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region.

Background: To report on the feasibility of total laryngopharyngectomy and free jejunal flap transfer for patient with hypopharyngeal cancer via the transoral robotic surgery (TORS) approach.

Material And Methods: A patient with hypopharyngeal cancer involving the post-cricoid region is used for demonstration of the TORS total laryngopharyngectomy and free jejunal flap reconstruction.

Results: The procedure starts with a cruciate incision for terminal tracheostomy. Read More

Sci Rep 2017 02 8;7:42296. Epub 2017 Feb 8.

University of Pittsburgh, Drug Discovery Institute Pittsburgh, PA, USA.

Organ interactions resulting from drug, metabolite or xenobiotic transport between organs are key components of human metabolism that impact therapeutic action and toxic side effects. Preclinical animal testing often fails to predict adverse outcomes arising from sequential, multi-organ metabolism of drugs and xenobiotics. Human microphysiological systems (MPS) can model these interactions and are predicted to dramatically improve the efficiency of the drug development process. Read More

Surg Today 2017 Jul 27;47(7):891-894. Epub 2016 Dec 27.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine/Graduate School of Medicine, Kagawa University, Kida County, Miki-Cho Ikenobe, Kagawa Prefecture, 1750-1, Japan.

This paper introduces our original technique of free jejunum transfer, in which a sero-muscular patch is used to cover the jejunum. Our results demonstrate its effectiveness for touch-up surgery after esophageal leakage. Read More

Cell Stress Chaperones 2017 01 28;22(1):123-134. Epub 2016 Nov 28.

Department of Biochemistry, Institute of Experimental Medicine, Russian Academy of Medical Sciences, Acad. Pavlov St., 12, St. Petersburg, 197376, Russia.

Reactive oxygen species damage various cell components including DNA, proteins, and lipids, and these impairments could be a reason for severe human diseases including atherosclerosis. Forkhead box O1 (FOXO1), an important metabolic transcription factor, upregulates antioxidant and proapoptotic genes during oxidative stress. Apolipoprotein A-I (ApoA-I) forms high density lipoprotein (HDL) particles that are responsible for cholesterol transfer from peripheral tissues to liver for removal in bile in vertebrates. Read More

Microsurgery 2016 Oct 17;36(7):567-572. Epub 2015 Dec 17.

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.

Background: Gastric pull-up (GPU) is the most common procedure for restoring the continuity of the alimentary tract. Yet, complications because of anastomotic problems are reported to be as high as 25% after this procedure. Managing the neck with anastomotic leakage or stricture following failed GPU and/or radiotherapy is formidable. Read More

BMC Microbiol 2016 10 11;16(1):238. Epub 2016 Oct 11.

Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Xinkang Road 46#, Ya'an, Sichuan Province, 625014, People's Republic of China.

Background: The present study was conducted to compare the differences in gut microbiota composition and gut-phenotypes among pig breeds, and determine whether these differences would transmit to mice colonized with fecal microbiota of different pig breeds. A total of 24 1-day-old germ-free BALB/C mice were divided into 3 groups (TFM, YFM and RFM), which were transplanted with intact fecal microbiota of Tibetan pig (TP), Yorkshire pig (YP) and Rongchang pig (RP), respectively.

Results: Results showed that different pig breeds exhibited distinct gut microbiota profile based on high-throughput pyrosequencing. Read More

Am Surg 2016 Jun;82(6):510-7

Department of Surgery, Kochi Medical School, Nankoku, Japan.

The construction of a gastric substitute pouch after gastrectomy for gastric cancer has been proposed to help ameliorate postprandial symptoms and nutritional performance. Adequate reconstruction after gastrectomy is an important issue, because postoperative patient quality of life (QOL) primarily depends on the reconstruction method. To this end, jejunal pouch (JP) reconstructions were developed to improve the patient's eating capacity and QOL by creating large reservoirs with improved reflux barriers to prevent esophagitis and residual gastritis. Read More

Auris Nasus Larynx 2016 Dec 8;43(6):693-7. Epub 2016 Apr 8.

Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.

Free jejunal transfer is the main technique used for reconstructing a circumferential defect caused by total pharyngo-laryngo-cervical-esophagectomy in certain cancer cases. We report a rare case of severe late-onset dysphagia caused by autonomous spastic peristalsis, which led to complete obstruction of the free jejunal route. A 70-year-old man underwent treatment for hypopharyngeal cancer involving total pharyngolaryngectomy with free jejunal transfer. Read More

J Anim Sci 2016 Mar;94(3):1287-95

Numerous animal feeding studies have investigated the presence of DNA from transgenic plants in tissues from different animal species, but the data reported are sometimes controversial. The aim of this study was to investigate the presence of transgenic DNA (tDNA) in the digesta and tissues of a meat rabbit breed fed genetically modified (GM) soybean meal. Fifteen male New Zealand White rabbits were used for the experimental trial. Read More

Pathol Res Pract 2016 May 17;212(5):437-43. Epub 2016 Feb 17.

Department of Orthopaedics and Traumatology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

Introduction: The aim of this study was to compare the efficacy of Nigella sativa in protection of jejunal mucosa against harmful effects of gamma radiation.

Methods: Radiotherapy group received abdominal gamma radiation of 15Gy in addition to physiological saline. Radiotherapy+Nigella sativa treatment group received abdominal gamma radiation of 15Gy in addition to Nigella sativa treatment in the amount of 400mg/kg. Read More

J Plast Surg Hand Surg 2016 Jun 3;50(3):135-41. Epub 2016 Mar 3.

b Department of Otorhinolaryngology , Kyoto Prefectural University of Medicine , Kyoto , Japan.

Background: Intravenous heparin administration is used to prevent thrombosis in free-flap transfer. However, it is unknown whether the use of heparin affects free-flap survival. The purpose of this study is to investigate the effect of heparin in free flap transfer. Read More

Microsurgery 2017 Feb 18;37(2):177-178. Epub 2016 Feb 18.

Department of Surgery, The Ohio State University, Columbus, OH.

Microsurgery 2016 Nov 21;36(8):658-663. Epub 2016 Jan 21.

Department of Plastic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: This report evaluates the behavior of anastomosed vessels and transferred flaps after anastomosed site infection in head and neck reconstruction.

Patients And Methods: Eleven free-flap cases after infection at the vascular pedicle site were included, the patency of which was observed macroscopically after re-exploration and pus drainage. Location was in the tongue (5 cases), oropharynx (3 cases), mouth floor (1 case), mandible (1 case), and hypopharynx (1 case). Read More

Sci Rep 2016 01 20;6:19685. Epub 2016 Jan 20.

School of Medicine, Konkuk University, Chungju 380-701, Korea.

Food allergy is a hypersensitive immune reaction to food proteins. We have previously demonstrated the presence of IL-10-producing CD5(+) B cells and suggested their potential role in regulating cow's milk casein allergy in humans and IgE-mediated anaphylaxis in mice. In this study, we determined whether IL-10-producing CD5(+) regulatory B cells control casein-induced food allergic responses in mice and, if so, the underlying mechanisms. Read More

J Anim Sci 2015 Aug;93(8):4048-57

The aim of the study was to clarify 1) the distribution of 6 α-tocopherol (α-Toc)-associated gene expressions in 20 major tissues, including metabolic, reproductive, endocrine, immune, and digestive and absorptive tissues, in relation to α-Toc status and 2) the change in expression patterns of the genes induced when α-Toc was orally administered to Japanese Black (JB) calves. This study examined weaned male JB calves ( = 10), of which 5 calves were orally administered α-Toc for 2 wk (30 IU·kg BW·d; TOC group). The others did not receive the α-Toc supplement and were the control (CONT) group. Read More

ORL J Otorhinolaryngol Relat Spec 2015 29;77(5):262-7. Epub 2015 Aug 29.

Department of Head and Neck Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Purpose Of The Study: To determine the appropriate salvage method after total necrosis of a jejunal graft after reconstruction of total laryngopharyngoesophagectomy or a larynx-preserving operation, considering the complexity of medical service in China.

Procedures: We reviewed 5 patients with a mean age of 61 years who developed total jejunal graft necrosis and underwent reconstruction of a free jejunal transfer in our hospital. The total number and choice of salvage procedures, the symptoms and the results of salvage for the 5 patients have been reviewed. Read More

Toxins (Basel) 2015 Aug 18;7(8):3210-23. Epub 2015 Aug 18.

Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn 10-719, Poland.

Zearalenone and its metabolites, α-zearalenol and β-zearalenol, demonstrate estradiol-like activity and disrupt physiological functions in animals. This article evaluates the carryover of zearalenone and its selected metabolites from the digesta to intestinal walls (along the entire intestines) in pre-pubertal gilts exposed to low doses of zearalenone over long periods of time. The term "carryover" describes the transfer of mycotoxins from feed to edible tissues, and it was used to assess the risk of mycotoxin exposure for consumers. Read More

J Dairy Sci 2015 Oct 29;98(10):7153-63. Epub 2015 Jul 29.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address:

The first meal of a neonatal calf after birth is crucial for survival and health. The present experiment was performed to assess the effects of colostrum quality on IgG passive transfer, immune and antioxidant status, and intestinal morphology and histology in neonatal calves. Twenty-eight Holstein neonatal male calves were used in the current study, 24 of which were assigned to 1 of 3 treatment groups: those that received colostrum (GrC), transitional milk (GrT, which was obtained after the first milking on 2-3 d after calving), and bulk tank milk (GrB) only at birth. Read More

J Reconstr Microsurg 2015 Nov 28;31(9):643-6. Epub 2015 Jul 28.

Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center, New York.

Background: Free jejunal transfer for pharyngoesophageal reconstruction has often been criticized for its associated donor-site morbidity. Conversely, the same argument has been invoked to support use of fasciocutaneous flaps, given their low incidence of donor-site complications. The purpose of the current study was to document donor-site complication rate with free jejunal flaps for pharyngoesophageal reconstruction, in the hands of an experienced surgeon. Read More

Ann Plast Surg 2015 Jul;75(1):98-101

From the *Department of Plastic, Reconstructive and Aesthetic Surgery, Akdeniz University School of Medicine, Antalya, Turkey; †Department of Plastic, Reconstructive and Aesthetic Surgery, Tatvan State Hospital, Bitlis, Turkey; ‡Department of Plastic, Reconstructive and Aesthetic Surgery, Adana Numune Research and Training Hospital, Adana, Turkey; and §Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey.

Jejunum flap for reconstruction of the vagina provides a durable, stable coverage; patent tube passage; and natural esthetic appearance. However, excessive mucous secretion is a major drawback of the technique.We have recently presented our cases in which strict 3-hour ischemia with lower mucus secretion was applied. Read More

Int J Surg 2015 Jun 10;18:95-8. Epub 2015 Apr 10.

Department of Head and Neck Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Electronic address:

Introduction: Reconstruction following total pharyngolaryngo-oesophagectomy (PLE) still challenges surgeons because of the extreme length of removed tissue. Gastric pull-up reconstruction, one of the most common reconstructive methods after PLE, has many complications such as anastomotic fistula and gastric necrosis caused by the high anastomotic tension. However, modifications of gastric pull-up reconstruction aiming to reducing the high anastomotic tension have been less reported compared with other aspects with this technique. Read More

Gan To Kagaku Ryoho 2014 Nov;41(12):1985-7

Dept. of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine.

The patient in this case study was a 71-year-old male who underwent distal esophagectomy with gastric tube reconstruction via a posterior mediastinal route for esophageal cancer 12 years previously. An endoscopy revealed a hypopharyngeal tumor in the right piriform fossa, and the histopathological diagnosis, based on a biopsy sample, was squamous cell carcinoma. Preoperative angiography of the right gastroepiploic artery revealed poor blood flow in the remnant esophagus. Read More

Animal 2015 Apr 8;9(4):622-8. Epub 2014 Dec 8.

Center for Animal Nutrigenomics and Applied Animal Nutrition,Alltech Inc.,Nicholasville,KY 40356,USA.

The objective was to study the effect of maternal supplementation with a yeast cell wall-based product containing a mannan-rich fraction (MRF) during gestation and lactation on piglet intestinal gene expression. First parity sows were fed experimental gestation and lactation diets with or without MRF (900 mg/kg). After farrowing, piglets were fostered within treatment, as necessary. Read More

Pflugers Arch 2015 Jun 1;467(6):1203-13. Epub 2014 Jul 1.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

Intestinal epithelial electrolyte secretion is activated by increase in intracellular cAMP or Ca(2+) and opening of apical Cl(-) channels. In infants and young animals, but not in adults, Ca(2+)-activated chloride channels may cause secretory diarrhea during rotavirus infection. While detailed knowledge exists concerning the contribution of cAMP-activated cystic fibrosis transmembrane conductance regulator (CFTR) channels, analysis of the role of Ca(2+)-dependent Cl(-) channels became possible through identification of the anoctamin (TMEM16) family of proteins. Read More

Microsurgery 2014 May;34(4):319-23

Secondary reconstruction of thoracic esophageal defects is a challenging problem for microsurgeons. Because of previous surgeries and coexisting disease, gastric pull-up, and creation of a pedicled colon conduit are often impossible. Transfer of a supercharged pedicled jejunum flap or free jejunal interposition is usually the last resort; however, identifying appropriate recipient vessels and adequately covering the reconstructive conduit are often difficult. Read More

FASEB J 2014 Aug 25;28(8):3494-505. Epub 2014 Apr 25.

School of Biological Sciences, The University of Hong Kong, Hong Kong, China

Secretin, a classical gastrointestinal hormone released from S cells in response to acid and dietary lipid, regulates pleiotropic physiological functions, such as exocrine pancreatic secretion and gastric motility. Subsequent to recently proposed revisit on secretin's metabolic effects, we have confirmed lipolytic actions of secretin during starvation and discovered a hormone-sensitive lipase-mediated mechanistic pathway behind. In this study, a 12 wk high-fat diet (HFD) feeding to secretin receptor-knockout (SCTR(-/-)) mice and their wild-type (SCTR(+/+)) littermates revealed that, despite similar food intake, SCTR(-/-) mice gained significantly less weight (SCTR(+/+): 49. Read More

Microsurgery 2014 Oct 24;34(7):582-5. Epub 2014 Mar 24.

Department of Plastic and Reconstructive Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.

Intestinal malrotation results from failure of intestinal rotation and fixation during fetal life. We report two cases of esophageal reconstruction with free jejunal flaps following total laryngopharyngectomy of hypopharyngeal and cervical esophageal carcinoma in which intestinal malrotation was detected during the jejunal flap harvesting. In both cases, the ligament of Treitz was absent, and the laparotomy incision was thus extended to identify the jejunum. Read More

PLoS One 2014 21;9(2):e89130. Epub 2014 Feb 21.

The State Key Laboratory for Agro-biotechnology, China Agricultural University, Beijing, China.

Lysozyme is often used as a feed additive and acts as an antimicrobial protein that enhances immune function and defends against pathogenic bacteria in pigs. In this study, we genetically added recombinant human lysozyme (rhLZ) to sow milk by somatic cell nuclear transfer and investigated whether the presence of recombinant human lysozyme can influence intestinal microbiota and morphology in sucking pigs. We generated transgenic cloned pigs and the first-generation hybrids (F1) produced high levels of rhLZ in milk. Read More

Ann Plast Surg 2014 Apr;72(4):435-8

From the *Department of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, Republic of Korea; †Department of Plastic and Reconstructive Surgery, Institute of Ischemic and Hypoxic Disease, Seoul National University College of Medicine, Seoul, Republic of Korea; ‡Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan; and §Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.

Introduction: Free jejunal transfer is commonly used as a reliable reconstructive method after total pharyngolaryngectomy. An anastomotic fistula is the most common complication in the early postoperative period, occurring in 5% to 35% of cases. There have been several studies regarding surgical techniques for minimizing fistula formation. Read More

Innate Immun 2015 Feb 19;21(2):151-60. Epub 2014 Feb 19.

Clinic for Poultry and Fish Medicine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.

Asymptomatic carriage of Campylobacter jejuni is highly prevalent in chicken flocks. Thus, we investigated whether chronic Campylobacter carriage affects chicken intestinal functions despite the absence of clinical symptoms. An experiment was carried out in which commercial chickens were orally infected with C. Read More

Br J Oral Maxillofac Surg 2014 Mar 24;52(3):247-50. Epub 2014 Jan 24.

Queen Elizabeth Hospital Birmingham, Edgbaston, United Kingdom.

Free jejunal transfer has been used in pharyngeal reconstruction for many years, but many have criticised it as being unreliable, poorly tolerant of radiotherapy, and susceptible to stenosis and dysphagia. Recently, the trend has been to use the anterolateral thigh (ALT) flap to overcome these problems, and many authors have reported good results. At the University of Birmingham we used the jejunal free flap for pharyngeal reconstruction for many years, but in view of recent reports we changed to the ALT flap. Read More

Br J Oral Maxillofac Surg 2014 Feb 5;52(2):106-10. Epub 2013 Dec 5.

University Hospital Birmingham, Consultant Vascular Surgeon, United Kingdom.

We retrospectively audited operative complications, success of flaps, and speech and swallowing outcomes in patients with head and neck cancer who had reconstruction with jejunal free tissue transfer to the pharynx. A total of 104 patients had jejunal free flaps between 1987 and 2009 at University Hospital, Birmingham. Management was by a multidisciplinary team, and the same vascular surgeon did all the anastomoses. Read More

HNO 2014 Jun;62(6):449-53

Klinik für HNO-Heilkunde, Kopf- und Halschirurgie, plastische Operationen, Malteser-Krankenhaus St. Anna, Albertus-Magnus-Str. 33, 47259, Duisburg, Deutschland,

Advanced laryngeal and hypopharyngeal carcinomas are associated with a poor prognosis and a pronounced loss of quality of life due to impairment of the swallowing and voice function. The fundamental therapeutic challenge is successful tumor control with concomitant rehabilitation of swallowing and voice functions. Further objectives are a low complications rate (fistula, aspiration) and prompt transfer to the adjuvant radio-oncologic therapy. Read More

PLoS One 2013 11;8(11):e79745. Epub 2013 Nov 11.

Department of Surgery, Michigan State University, East Lansing, Michigan, United States of America.

Although we stimulate enterocytic proliferation to ameliorate short gut syndrome or mucosal atrophy, less effort has been directed at enterocytic differentiation. Schlafen 3 (Slfn3) is a poorly understood protein induced during IEC-6 enterocytic differentiation. We hypothesized that exogenous manipulation of Slfn3 would regulate enterocytic differentiation in vivo. Read More

J Gastrointest Surg 2014 Feb 4;18(2):286-94; discussion 294. Epub 2013 Sep 4.

Division of Pediatric Surgery, St Louis Children's Hospital, One Children's Place, Suite 5S40, St. Louis, MO, 63110, USA.

Previous studies have shown that high-fat diet (HFD) enhances adaptation if provided immediately following small bowel resection (SBR). The purpose of this study was to determine if HFD could further enhance villus growth after resection-induced adaptation had already taken place. C57/Bl6 mice underwent a 50 % proximal SBR or sham operation and were then provided a standard rodent liquid diet (LD) ad lib. Read More

Exp Anim 2013 ;62(2):109-16

Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

An unidentified Helicobacter species, strain MIT 01-6451, was frequently detected in mice obtained from domestic commercial and academic institutions in Japan. To partially characterize this strain, its distributions in the gastrointestinal tract and hepatobiliary system of mice were investigated. In gastrointestinal tissues, this strain was detected in all cecum, colon, and feces samples tested, whereas fewer mice were positive in the ileum, jejunum, and duodenum. Read More

J Plast Reconstr Aesthet Surg 2013 May 6;66(5):e133-6. Epub 2013 Feb 6.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Science, University of Okayama, Okayama 700-8558, Japan.

Free jejunal transfer using microsurgery after oesophageal or pharyngeal cancer resection is a useful operative approach. However, the disadvantage of free tissue transfer is the risk of necrosis of the transferred tissue due to impaired blood supply. In addition, jejunal flaps are more prone to blood-flow disorders such as ischaemia and congestion compared with other types of flaps. Read More

J Reconstr Microsurg 2013 Feb 2;29(2):137-40. Epub 2013 Jan 2.

Department of Plastic and Reconstructive Surgery, Nihon University School of Medicine, Tokyo, Japan.

We treated a case that exhibited dissociation between blood flow in the transferred jejunum and the monitoring flap. The monitoring flap showed a false-negative, indicating blood flow to be favorable despite blood congestion in the transferred jejunum. The patient was a 69-year-old man. Read More

Microsurgery 2013 Mar 15;33(3):169-72. Epub 2012 Nov 15.

Department of Plastic and Reconstructive Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

To clarify whether a supercharged free jejunal transfer would have a different clinical outcome from the usual transfer method, we examined clinical data from cases of esophago-pharyngeal reconstruction. Fifty-three patients in whom the hypopharynx and cervical esophagus was reconstructed with a free jejunal transfer were divided into two groups: 19 normal procedures and 34 supercharged. Clinical outcomes including intraoperative and postoperative events, complications and deglutition were compared statistically. Read More

Poult Sci 2012 Nov;91(11):2949-57

Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.

Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea. The present investigations aimed to elucidate whether the absence of diarrhea during acute Salmonella enterica serovar Enteritidis (Salmonella Enteritidis) infection may be linked to specific changes in the electrophysiological properties of the chicken gut. Read More

J Oral Maxillofac Surg 2013 Mar 29;71(3):628-35. Epub 2012 Aug 29.

Department of Oral, Maxillofacial and Plastic Facial Surgery, University Hospital of the Aachen University, Aachen, Germany.

Purpose: The reconstruction of extended soft tissue and bony defects in the maxillofacial region with microsurgical flaps is considered to be the therapy of first choice. The aim of this retrospective study was to detect different influencing factors concerning flap survival.

Materials And Methods: We examined the data of 406 patient cases (121 female and 285 male cases; mean age, 57 years) undergoing reconstruction with a microsurgical flap in our facility between 1998 and 2010. Read More