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J AAPOS 2021 Jun 21. Epub 2021 Jun 21.

Microb Biotechnol 2021 Jun 24. Epub 2021 Jun 24.

Department of Pathogenic Microbiology & Immunology, School of Basic Medical Sciences, Xi'an Jiao Tong University Health Science Center, 76 West Yanta Road, Xi'an, 710061, China.

Trichophyton rubrum is responsible for the majority of dermatophytosis. Current systemic and topical antifungals against dermatophytosis are often tedious and sometimes unsatisfactory. Antimicrobial photodynamic therapy (aPDT) is a non-invasive alternative suitable for the treatment of superficial fungal infections. Read More

Indian J Dermatol Venereol Leprol 2021 Jun 7:1-7. Epub 2021 Jun 7.

Calcutta Skin Institute, 169, Scheme 6 M, C I T Road, Kankurgachi, Kolkata, West Bengal, India.

Background: The prevalence of dermatophytes varies with season, geographical area, socio-economic factors and effective management strategies.

Aims: The aim of the study was to assess the prevalence of pathogenic dermatophytes, clinical types of dermatophyte fungal infection, and in vitro antifungal drug susceptibility testing against dermatophytes.

Methods: Three hundred and ninety five patients with dermatophytosis were enrolled from five cities (Mumbai, Delhi, Lucknow, Kolkata and Hyderabad) across India. Read More

J Adv Pharm Technol Res 2021 Apr-Jun;12(2):169-174. Epub 2021 Apr 27.

Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.

Tinea capitis is local alopecia caused by a dermatophyte infection of the scalp. produces the squalene epoxidase enzyme, which has a crucial role in prolonged dermatophyte infection, as well as in synthesizing fatty acids in this dermatophyte group. This study analyzes compounds as anti-alopecia by inhibiting the squalene epoxidase enzyme formation, . Read More

J Mycol Med 2021 May 26;31(3):101157. Epub 2021 May 26.

Department of Medical Microbiology and Parasitology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University Kano P.M.B 3011, Kano- Nigeria.

Background: Tinea capitis is a dermatophyte infection of the scalp and hair that affects a large number of people worldwide. The disease commonly affects children and manifests with varying degrees of hair loss, scalp inflammation, and psychosocial impact. In Nigeria, the burden of tinea capitis is worrisome affecting over 15,000,000 school-age children. Read More

J Eur Acad Dermatol Venereol 2021 Jun 19. Epub 2021 Jun 19.

Dept. of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Tinea capitis is a fungal infection mostly affecting children. Epidemiology is changing over time due to migration and it has been estimated that up to 40 % of children from certain developing countries are affected. The mechanism of transmission is still unclear although asymptomatic carriage seems to have an influence in establishing persistent reservoirs that can cause or fuel epidemics. Read More

Mycoses 2021 Jun 18. Epub 2021 Jun 18.

Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Wrocław, Poland.

Fungal infections present with a broad spectrum of diseases in humans (from relatively mild superficial infections of the skin and mucous membranes to the invasive or chronic infections of internal organs, which have a high mortality rate). Globally, up to 1.6 million people die each year as a result of various types of mycoses. Read More

Sci Rep 2021 Jun 17;11(1):12789. Epub 2021 Jun 17.

iBiMed-Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Campus Universitário de Santiago, Agra do Crasto-Edifício 30, 3810-193, Aveiro, Portugal.

Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Read More

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211020879. Epub 2021 Jun 2.

Clinic of Dermatology, Aristide Le Dantec Hospital, Dakar, Senegal.

A 9-year-old girl presented a large inflammatory cup-shaped scalp lesion with alopecia surrounded by pustules, dander, and suppuration associated with an occipital inflammatory lymphadenopathy for 1 month. Wood's light exam was positive as well as KOH mount showing ectothrix type hair involvement. Hair and pus culture on Sabouraud dextrose agar (SDA) added with chloramphenicol and supplemented with cycloheximide isolated a dermatophyte species identified as according to the colonies features. Read More

Cureus 2021 May 6;13(5):e14864. Epub 2021 May 6.

Department of Cardiology, U N Mehta Institute of Cardiology and Research Centre, Ahmedabad, IND.

Neurocysticercosis is a parasitic disease often involving the central nervous system by and is commonly seen in developing countries. The majority of these cases have either isolated brain involvement or combined involvement of the brain and spinal cord. Isolated involvement of the spinal cord is very rare. Read More

Expert Rev Anti Infect Ther 2021 Jun 9. Epub 2021 Jun 9.

Mediprobe Research Inc., London, ON, CAN.

Introduction: Onychomycosis, a common nail disorder caused by fungal infection, can be managed pharmaceutically with oral or topical treatments. While oral treatments are often used first-line to treat nail infections, these systemic antifungals are not appropriate for all patients, and no oral treatments are approved for use in children in the USA. Given this need, topical antifungals were developed, which can be used as monotherapy or in combination with oral drugs. Read More

Antimicrob Agents Chemother 2021 Jun 7:AAC0032121. Epub 2021 Jun 7.

Vyome Therapeutics Limited, New Delhi, India.

Recalcitrant dermatophytic infections of the glabrous skin (tinea corporis/cruris/faciei) pose a huge challenge to healthcare systems. Combinations of oral and topical drugs may potentially improve cure rates but the same has never been objectively assessed for this condition in laboratory or clinical studies.The presentstudy was undertaken with an aim of identifying synergistic combinations of oral and topical antifungals by testing clinical isolates obtained from patients with recalcitrant tinea corporis/cruris. Read More

Cutis 2021 Apr;107(4):E30-E32

Dermatology Service Capital and Coast District Health Board, Wellington Regional Hospital, New Zealand.

Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Cockerell Dermatopathology, Dallas, TX; Icahn School of Medicine at Mount Sinai, New York, NY; Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX; Department of Pathology, Veterans Affairs North Texas Health Care System, Dallas, TX; Department of Pathology, UT Southwestern Medical Center, Dallas, TX; Dermatology and Skin Surgery Clinic, Alexandria, LA; Department of Dermatology, UT Southwestern Medical Center, Dallas, TX; and Rheumatology Section, Veterans Affairs North Texas Health Care System, Dallas, TX.

Abstract: Leukocytoclastic vasculitis (LCV) is a small vessel inflammatory condition considered to be caused by circulating immune complexes and often occurs after an acute infection or exposure to a new medication, although it may be associated with an underlying systemic disease or be idiopathic in nature. It is important to determine the etiology, identify the extent of the disease for early intervention and appropriate management, and treat and/or eliminate the underlying cause. Here, we report cases of scurvy and tinea corporis that presented with histopathologic features of LCV and had significant clinical improvement with treatment of the underlying etiologies. Read More

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):114

Department of Dermatology, Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha, India.

Amino Acids 2021 Jun 3. Epub 2021 Jun 3.

Department of Pharmaceutical Technology and Biochemistry and BioTechMed Center, Gdańsk University of Technology, Gdańsk, Poland.

Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. Read More

Photodermatol Photoimmunol Photomed 2021 Jun 3. Epub 2021 Jun 3.

Department of Dermatology, Miguel Servet University Hospital, IIS Aragón, Zaragoza, Spain.

Mycoses 2021 Jun 2. Epub 2021 Jun 2.

Cheikh Anta Diop University of Dakar, Dakar, Senegal.

Background: In developing countries, superficial fungal infections (SFI) are endemic and cause a therapeutic problem because of the duration and cost of treatment. Community living and promiscuity are key factors in the direct or indirect transmission and spread of these diseases.

Objectives: The objective was to study the epidemiological aspects of SFI, among koranic school children in two localities in Senegal. Read More

Molecules 2021 May 31;26(11). Epub 2021 May 31.

The State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co. Ltd., Dongguan 523871, China.

The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. Read More

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Dermatology, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.

The skin is the outermost layer of the body and is exposed to many environmental stimuli, which cause various inflammatory immune responses in the skin. Among them, fungi are common microorganisms that colonize the skin and cause cutaneous fungal diseases such as candidiasis and dermatophytosis. The skin exerts inflammatory responses to eliminate these fungi through the cooperation of skin-component immune cells. Read More

Actas Dermosifiliogr 2021 May 20. Epub 2021 May 20.

Servicio de Dermatología, Complejo Hospitalario Universitario de A Coruña, La Coruña, Spain.

Med Clin North Am 2021 Jul;105(4):783-797

Department of Dermatology, University of Alabama at Birmingham, 510 20th Street South, FOT Suite 858, Birmingham, AL 35233, USA. Electronic address:

This evidence-based review highlights cutaneous infections of bacterial, viral, and fungal origin that are frequently encountered by clinicians in all fields of practice. With a focus on treatment options and management, the scope of this article is to serve as a reference for physicians, regardless of field of specialty, as they encounter these pathogens in clinical practice. Read More

J Eur Acad Dermatol Venereol 2021 May 29. Epub 2021 May 29.

Nirvan Skin Clinic, Vadodara, India.

Clin Exp Dermatol 2021 May 28. Epub 2021 May 28.

Dermatology department, Fattouma Bourguiba University Hospital, University of Monastir, Research Laboratory LR20SP03A, Monastir, Tunisia.

Erythema nodosum (EN) is the most frequent variety of acute panniculitis in children. Rarely, it may be considered as a dermatophytid reaction to tinea of the scalp . A few cases of EN associated with dermatophytie infections are reported in the literature. Read More

Dermatol Ther 2021 May 27:e15010. Epub 2021 May 27.

Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Tinea capitis (TC) is the most common dermatophyte infection in children. Fungal culture the gold standard diagnostic method takes several weeks and has poor yields. Trichoscopy helps in rapid diagnosis and could work as a monitoring tool during antifungal therapy. Read More

BMJ Case Rep 2021 May 25;14(5). Epub 2021 May 25.

Division of Dermatology, The University of Kansas Health System, Kansas City, Kansas, USA.

Terbinafine is often considered contraindicated in those with liver disease, as one of the known side effects is hepatotoxicity. We report the first case documenting the safe use of oral terbinafine in a 77-year-old woman with stable autoimmune hepatitis presenting with extensive tinea corporis. Precautions were carried out to minimise the risk of worsening hepatotoxicity, including consultation with the patient's hepatologist, limiting terbinafine exposure to less than 6 weeks, monitoring of liver function tests, and patient education. Read More

J Clin Lab Anal 2021 May 24:e23850. Epub 2021 May 24.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Superficial and cutaneous fungal infections are common in tropical areas. The aim of this study was to provide a basic database of superficial and cutaneous mycoses and the most common etiological agents among patients.

Methods: Between 2015 and 2019, a total of 1807 patients suspected of superficial and cutaneous mycosis referring to the mycology laboratory of Shiraz medical school, Fars, Iran were evaluated. Read More

J Dermatol 2021 May 24. Epub 2021 May 24.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Efinaconazole is a topical antifungal drug approved in Japan for tinea unguium. Although topical treatments generally have low cure rates with a prolonged therapy period, a Cochrane review confirmed that high-quality evidence supports the effectiveness of efinaconazole for the complete cure of tinea unguium. Combination therapy is a way to improve the cure rate of onychomycosis. Read More

Fungal Biol 2021 Jun 23;125(6):459-468. Epub 2021 Jan 23.

W. Szafer Institute of Botany, Polish Academy of Sciences, Lubicz 46, PL-31-512, Kraków, Poland. Electronic address:

A clade where the most halotolerant fungus in the world - Hortaea werneckii, belongs (hereafter referred to as Hortaea werneckii lineage) includes five species: Hortaea werneckii, H. thailandica, Stenella araguata, Eupenidiella venezuelensis, and Magnuscella marina, of which the first species attracts increasing attention of mycologists. The species diversity and phylogenetic relationships within this lineage are weakly known. Read More

J Eur Acad Dermatol Venereol 2021 May 20. Epub 2021 May 20.

Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: Descriptions of cutaneous findings associated with COVID-19 have not been consistently accompanied by histopathology or confirmatory testing for SARS-CoV-2.

Objective: To describe and classify the cutaneous findings with supporting histopathology of confirmed COVID-19 inpatients.

Methods: We included consecutive inpatients with a confirmed diagnosis of COVID-19 for whom a dermatology consult was requested. Read More