1,404 results match your criteria Tick-Borne Diseases Rocky Mountain Spotted Fever


Multistate Survey of American Dog Ticks (Dermacentor variabilis) for Rickettsia Species.

Vector Borne Zoonotic Dis 2019 Apr 3. Epub 2019 Apr 3.

1 Rickettsial Zoonoses Branch, National Center for Emerging and Zoonotic Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia.

Dermacentor variabilis, a common human-biting tick found throughout the eastern half and along the west coast of the United States, is a vector of multiple bacterial pathogens. Historically, D. variabilis has been considered a primary vector of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever. Read More

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http://dx.doi.org/10.1089/vbz.2018.2415DOI Listing
April 2019
2 Reads

Diagnostic Methods Used to Classify Confirmed and Probable Cases of Spotted Fever Rickettsioses - United States, 2010-2015.

MMWR Morb Mortal Wkly Rep 2019 Mar 15;68(10):243-246. Epub 2019 Mar 15.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC.

Spotted fever rickettsioses (SFR), including Rocky Mountain spotted fever (RMSF), are nationally notifiable diseases in the United States caused by spotted fever group Rickettsia. The annual incidence of SFR increased from 1.7 cases per 1 million persons in 2000 to 13. Read More

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http://dx.doi.org/10.15585/mmwr.mm6810a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421962PMC

Circulation of spotted fever group rickettsiae among dogs seropositive for Leishmania spp. in an urban area of Brazil.

Rev Soc Bras Med Trop 2019 Feb 21;52:e20180133. Epub 2019 Feb 21.

Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niterói, RJ, Brasil.

Introduction: Dogs play an epidemiological role in several vector-borne diseases that affect human and animal health worldwide. We aimed to identify rickettsial circulation among dogs with canine visceral leishmaniasis (CVL) from a region endemic for both diseases.

Methods: CVL-seropositive dogs were screened for spotted fever group rickettsiae using an indirect immunofluorescence assay. Read More

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http://dx.doi.org/10.1590/0037-8682-0133-2018DOI Listing
February 2019
2 Reads

Hosts mobility and spatial spread of Rickettsia rickettsii.

PLoS Comput Biol 2018 12 26;14(12):e1006636. Epub 2018 Dec 26.

Robert Koch-Institute, Berlin, Germany.

There are a huge number of pathogens with multi-component transmission cycles, involving amplifier hosts, vectors or complex pathogen life cycles. These complex systems present challenges in terms of modeling and policy development. A lethal tick-borne infectious disease, the Brazilian Spotted Fever (BSF), is a relevant example of that. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324817PMC
December 2018
1 Read

Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host.

Infect Immun 2019 Feb 24;87(2). Epub 2019 Jan 24.

Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University (CVM-KSU), Manhattan, Kansas, USA

Rocky Mountain spotted fever (RMSF) is a potentially fatal tick-borne disease in people and dogs. RMSF is reported in the United States and several countries in North, Central, and South America. The causative agent of this disease, , is transmitted by several species of ticks, including , , and RMSF clinical signs generally include fever, headache, nausea, vomiting, muscle pain, lack of appetite, and rash. Read More

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http://iai.asm.org/lookup/doi/10.1128/IAI.00628-18
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http://dx.doi.org/10.1128/IAI.00628-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346123PMC
February 2019
35 Reads

Fatal case of co-infected of rickettiosis and dengue virus in Mexico

Rev Med Inst Mex Seguro Soc 2018 Oct 25;56(3):320-322. Epub 2018 Oct 25.

Universidad de Sonora, Departamento de Medicina y Ciencias de la Salud. Hermosillo, Sonora, México

Background: Rocky Mountain spotted fever (RMSF) is a disease spread by an infected tick and it is lethal if patient is not treated on time. Symptom similarities with other exanthematous diseases may delay the diagnosis, which leads to its mortality.

Clinical Case: We show the lethal case of a patient with medical record of high blood pressure and no history of travel, who lived in Sonora, Mexico. Read More

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October 2018
2 Reads

Exposure to Ticks and their Pathogens in Northeast Missouri.

Authors:
Deborah A Hudman

Mo Med 2018 Jul-Aug;115(4):374-379

Deborah A. Hudman, MS, is in the Department of Microbiology/Immunology, A.T. Still University Kirksville College of Osteopathic Medicine.

While the prevalence of human pathogens has been quantified in ticks in Adair County, Missouri, the prevalence of residents acquiring tick-borne diseases and seeking medical treatment has not. A public survey (n=109) revealed that 96% of respondents reported finding attached ticks on their person; of these, 38% developed symptoms post tick bite; of these, 55% reported consultation with a health care provider. Overall, 89% of practitioners surveyed had treated at least one patient for tick-borne disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140261PMC
September 2018
6 Reads

Evidence of locally acquired spotted fever group rickettsioses in Southeast Texas, 2008-2016.

Zoonoses Public Health 2018 11 27;65(7):897-901. Epub 2018 Aug 27.

Section of Pediatric Tropical Medicine, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

We identified six paediatric case-patients from southeast Texas diagnosed with confirmed or probable Spotted Fever Group Rickettsiosis (SFGR) between 2008 and 2016. Only one case had a history of travel to an endemic area. Clinical and laboratory findings strongly suggest locally acquired Rocky Mountain Spotted Fever in one Houston patient. Read More

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http://dx.doi.org/10.1111/zph.12518DOI Listing
November 2018
4 Reads

Serologic assessment for exposure to spotted fever group rickettsiae in dogs in the Arizona-Sonora border region.

Zoonoses Public Health 2018 12 21;65(8):984-992. Epub 2018 Aug 21.

Arizona Department of Health Services, Office of Infectious Disease Services, Phoenix, Arizona.

Rocky Mountain spotted fever (RMSF) is a severe tick-borne rickettsial illness. In the south-western United States and Mexico, RMSF displays unique epidemiologic and ecologic characteristics, including Rhipicephalus sanguineus sensu lato (brown dog tick) as the primary vector. Expansion and spread of the disease from hyperendemic regions of Arizona or Mexico to new areas is a key public health concern. Read More

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http://dx.doi.org/10.1111/zph.12517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217800PMC
December 2018
3 Reads

Effects of Rickettsia amblyommatis Infection on the Vector Competence of Amblyomma americanum Ticks for Rickettsia rickettsii.

Vector Borne Zoonotic Dis 2018 11 10;18(11):579-587. Epub 2018 Aug 10.

Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention , Atlanta, Georgia .

Although Dermacentor spp. ticks are considered the primary vectors of Rickettsia rickettsii in the United States, other North American tick species are also capable of transmitting the agent, including the lone star tick-Amblyomma americanum. The lone star tick is an aggressive human-biting tick abundant in the South, Central, and Mid-Atlantic United States, which has been shown to be a competent vector of R. Read More

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http://dx.doi.org/10.1089/vbz.2018.2284DOI Listing
November 2018
4 Reads

Septic Shock Caused by Rocky Mountain Spotted Fever in a Suburban Texas Patient with Pet Dog Exposure: A Case Report.

Am J Case Rep 2018 Aug 4;19:917-919. Epub 2018 Aug 4.

Department of Internal Medicine, The Methodist Hospital, Houston, TX, USA.

BACKGROUND Rocky Mountain spotted fever (RMSF) is associated with high mortality and requires prompt identification and treatment to ensure better outcomes. CASE REPORT We describe an advanced case of RMSF in a 45-year-old female patient with pet dog exposure who presented with altered mental status, dyspnea, and ataxia progressing to septic shock and acute hypoxic respiratory failure requiring intubation and mechanical ventilation. CONCLUSIONS This case illustrates the importance of keeping RMSF in the differential diagnosis in patient populations outside of the usual geographic areas of incidence in the appropriate clinical setting. Read More

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http://dx.doi.org/10.12659/AJCR.909636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091339PMC
August 2018
18 Reads

Abiotic and habitat drivers of tick vector abundance, diversity, phenology and human encounter risk in southern California.

PLoS One 2018 31;13(7):e0201665. Epub 2018 Jul 31.

Department of Biology, Stanford University, Stanford, California, United States of America.

The distribution, abundance and seasonal activity of vector species, such as ticks and mosquitoes, are key determinants of vector-borne disease risk, and are strongly influenced by abiotic and habitat conditions. Despite the numerous species of tick vectors in the heavily populated North American West Coast, all but Ixodes pacificus, the primary vector of the Lyme disease spirochete, is poorly characterized with regard to seasonal activity patterns and fine scale drivers of distribution and abundance, particularly in heavily populated regions of southern California. This lack of knowledge inhibits both scientific understanding and public health efforts to minimize vector exposure and risk of pathogen transmission to humans. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067749PMC
February 2019
2 Reads

Diversity of rickettsiae and potential vectors of spotted fever in an area of epidemiological interest in the Cerrado biome, midwestern Brazil.

Med Vet Entomol 2018 12 3;32(4):481-489. Epub 2018 Jul 3.

Programa de Pós-Graduação em Biodiversidade e Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

The Brazilian state of Goiás, untouched by spotted fever (SF) until 2012, has subsequently reported cases of the disease in several regions. This study aimed to survey the diversity of potential vectors and rickettsia in areas of Goiás under environmental surveillance or case investigation for SF. Collected specimens were assayed with molecular biology technology using DNA extraction, amplification and sequencing of fragments of the genes gltA, ompA, ompB and sca4 to detect rickettsia in ticks and fleas. Read More

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http://dx.doi.org/10.1111/mve.12315DOI Listing
December 2018
2 Reads

The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum.

MBio 2018 06 26;9(3). Epub 2018 Jun 26.

Host-Parasite Interactions Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA

Strains of , the tick-borne agent of Rocky Mountain spotted fever, vary considerably in virulence. Genomic comparisons of strains have identified a relatively small number of genes divergent in an avirulent strain. Among these is one annotated as ankyrin repeat protein 2 (RARP-2). Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00975-18
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http://dx.doi.org/10.1128/mBio.00975-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020290PMC
June 2018
13 Reads

Mosquito and Tick-borne Illnesses in the United States. Guidelines for the Recognition and empiric Treatment of Zoonotic Diseases in the Wilderness.

Authors:
Suresh Antony

Infect Disord Drug Targets 2018 Jun 26. Epub 2018 Jun 26.

Department of Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, Texas and Burrell College of Osteopathic Medicine, Las Cruses, New Mexico. United States.

In the United States, tick-borne illnesses account for a significant number of patients that have been seen and treated by health care facilities. This in turn, has resulted in a significant morbidity and mortality and economic costs to the country. The distribution of these illnesses is geographically variable and is related to the climate as well. Read More

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http://www.eurekaselect.com/163221/article
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http://dx.doi.org/10.2174/1871526518666180626123340DOI Listing
June 2018
17 Reads

Prevalence of Rickettsia Species (Rickettsiales: Rickettsiaceae) in Dermacentor variabilis Ticks (Acari: Ixodidae) in North Carolina.

J Med Entomol 2018 Aug;55(5):1284-1291

Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC.

The American dog tick, Dermacentor variabilis (Say), is a vector of spotted fever group (SFG) rickettsiae, including Rickettsia rickettsii the causative organism of Rocky Mountain spotted fever (RMSF). In North Carolina, SFG rickettsioses (including RMSF) are a leading cause of tick-borne illness. Knowledge of the infection rate and geographic distribution of D. Read More

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http://dx.doi.org/10.1093/jme/tjy074DOI Listing
August 2018
4 Reads

Vital Signs: Trends in Reported Vectorborne Disease Cases - United States and Territories, 2004-2016.

MMWR Morb Mortal Wkly Rep 2018 May 4;67(17):496-501. Epub 2018 May 4.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Fort Collins, Colorado.

Introduction: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. Read More

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http://www.cdc.gov/mmwr/volumes/67/wr/mm6717e1.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6717e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933869PMC
May 2018
82 Reads

The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature.

J Emerg Med 2018 07 22;55(1):42-50. Epub 2018 Apr 22.

Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Rocky Mountain spotted fever (RMSF) is potentially deadly and can present subtly with signs and symptoms overlapping with other clinical conditions. Delayed diagnosis can be fatal.

Objective: This review provides an evidence-based summary of the current data for the evaluation and management of RMSF in the emergency department. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.02.043DOI Listing
July 2018
1 Read

[A fatal case series of Rocky Mountain spotted fever in Sonora, México].

Biomedica 2018 Mar 15;38(1):69-76. Epub 2018 Mar 15.

Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Hermosillo, México.

Introduction: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly.

Objective: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México.

Materials And Methods: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. Read More

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http://dx.doi.org/10.7705/biomedica.v38i0.3507DOI Listing
March 2018
6 Reads

Descriptions of two new cases of Rocky Mountain spotted fever in Panama, and coincident infection with Rickettsia rickettsii in Rhipicephalus sanguineus s.l. in an urban locality of Panama City, Panama.

Epidemiol Infect 2018 05 5;146(7):875-878. Epub 2018 Apr 5.

Instituto Conmemorativo Gorgas de Estudios de la Salud,Ciudad de Panamá,Panama.

The clinical and pathologic characterisation of two fatal cases of tick-borne rickettsiosis in rural (El Valle) and urban (City of Panama) Panama are described. Clinical and autopsy findings were non-specific, but the molecular analysis was used to identify Rickettsia rickettsii in both cases. No ticks were collected in El Valle, while in the urban case, R. Read More

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http://dx.doi.org/10.1017/S0950268818000730DOI Listing
May 2018
9 Reads

Detection of Rickettsia spp. in ticks (Acari: Ixodidae) of domestic animals in Colombia.

Ticks Tick Borne Dis 2018 05 9;9(4):819-823. Epub 2018 Mar 9.

Departamento de Biologia, Instituto de Biociências, UNESP - Universidade Estadual Paulista, Avenida 24-A, 1515, Bairro Bela Vista, Rio Claro, SP, CEP13506-900, Brazil.

Rickettsiosis are emerging or re-emerging diseases, with a worldwide distribution associated to transmission by arthropod vectors. Rickettsia species belong to the spotted fever group (SFG) and are transmitted by hard ticks (Acari: Ixodidae) that may act as vectors and reservoirs. This study carried out a molecular detection of Rickettsia from 7 species of the family Ixodidae collected from domestic hosts by PCR amplification of fragments of the citrate synthase "gltA" gene and outer membrane protein "ompA" gene. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.03.006DOI Listing
May 2018
4 Reads

Tick borne illness - Rocky mountain spotted fever.

Authors:
Robin B McFee

Dis Mon 2018 May 15;64(5):185-194. Epub 2018 Mar 15.

Department of Emergency/Family Medicine, Debusk College of Osteopathic Medicine, Lincoln Memorial University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.disamonth.2018.01.006DOI Listing
May 2018
4 Reads

What's eating you? clinical manifestations of Dermacentor tick bites.

Cutis 2018 Jan;101(1):19;20;36

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, USA.

Dermacentor ticks are hard ticks found throughout most of North America and are easily identified by their large size, ornate scutum, and prominent dorsal pits. They are important disease vectors and are implicated in transmission of Rocky Mountain spotted fever (RMSF), Colorado tick fever, tularemia, and erlichiosis. They also are an important cause of fatal tick paralysis. Read More

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January 2018
21 Reads

EMERGING INFECTIOUS DISEASES - OVERVIEW.

Authors:
Robin B McFee

Dis Mon 2018 May 7;64(5):163-169. Epub 2018 Mar 7.

Debusk College of Osteopathic Medicine, Lincoln Memorial University. Electronic address:

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http://dx.doi.org/10.1016/j.disamonth.2018.01.002DOI Listing
May 2018
3 Reads

Rocky Mountain spotted fever: brain imaging findings.

Braz J Infect Dis 2018 Mar - Apr;22(2):153-154. Epub 2018 Mar 1.

Universidade Estadual de Campinas, Departamento de Clínica Médica, Campinas, SP, Brazil.

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http://dx.doi.org/10.1016/j.bjid.2018.02.004DOI Listing
June 2018
7 Reads

[Some information regarding the historical development of typhoid fever in Chile].

Authors:
Enrique Laval

Rev Chilena Infectol 2017 Oct;34(5):491-493

Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.

During the historical development of typhoid fever in Chile, its confusion with other infectious diseases is particularly noteworthy, especially with murine typhus, a problem that was mainly resolved during the 1918 epidemic. The importance of chloramphenicol treatment is also highlighted, which meant an enormous improvement in typhoid/paratyphoid fevers, in combination with public health and health education actions that allowed to almost eliminate these infectious diseases in our country. Read More

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http://dx.doi.org/10.4067/S0716-10182017000500491DOI Listing
October 2017
4 Reads

Comparative genomic analysis of Rickettsia rickettsii for identification of drug and vaccine targets: tolC as a proposed candidate for case study.

Acta Trop 2018 Jun 21;182:100-110. Epub 2018 Feb 21.

Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, 211004, India. Electronic address:

Background: Antibiotic resistance is increasing rapidly in pathogenic organisms, creating more complications for treatment of diseases. Rocky Mountain spotted fever (RMSF) is a neglected tropical disease in humans caused by Rickettsia rickettsii for which no effective therapeutic is available. Subtractive genomics methods facilitate the characterization of non-homologous essential proteins that could be targeted for the discovery of potential therapeutic compounds against R. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.02.021DOI Listing
June 2018
5 Reads

Analysis of the Salivary Gland Transcriptome of Unfed and Partially Fed Ticks and Descriptive Proteome of the Saliva.

Front Cell Infect Microbiol 2017 21;7:476. Epub 2017 Nov 21.

Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Ticks are obligate blood feeding ectoparasites that transmit a wide variety of pathogenic microorganisms to their vertebrate hosts. is vector of , the causative agent of Rocky Mountain spotted fever (RMSF), the most lethal rickettsiosis that affects humans. It is known that the transmission of pathogens by ticks is mainly associated with the physiology of the feeding process. Read More

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http://journal.frontiersin.org/article/10.3389/fcimb.2017.00
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http://dx.doi.org/10.3389/fcimb.2017.00476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702332PMC
July 2018
18 Reads

Influence of microhabitat use and behavior of Amblyomma sculptum and Amblyomma dubitatum nymphs (Acari: Ixodidae) on human risk for tick exposure, with notes on Rickettsia infection.

Ticks Tick Borne Dis 2018 01 16;9(1):67-71. Epub 2017 Oct 16.

Laboratório de Ixodologia, Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Av. Pará, 1720/Campus Umuarama-Bloco 2T, CEP 38400-902 Uberlândia, Minas Gerais, Brazil. Electronic address:

Brazilian spotted fever (BSF) is a potentially lethal human disease caused by Rickettsia rickettsii transmitted by ticks, including Amblyomma sculptum. However, in Southeast Brazil, where most BSF cases occur, capybaras are key hosts for both A. sculptum and Amblyomma dubitatum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173028
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http://dx.doi.org/10.1016/j.ttbdis.2017.10.007DOI Listing
January 2018
10 Reads

Th1 epitope peptides induce protective immunity against Rickettsia rickettsii infection in C3H/HeN mice.

Vaccine 2017 12 10;35(51):7204-7212. Epub 2017 Oct 10.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20# Dong-Dia-Jie Street, Fengtai, Beijing 100071, China; Army Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute for Tuberculosis Research, The 309th Hospital of Chinese PLA, 17# Hei-Shan-Hu Road, Haidian, Beijing 100091, China. Electronic address:

Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. Read More

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http://dx.doi.org/10.1016/j.vaccine.2017.09.068DOI Listing
December 2017
11 Reads

Fatal Rocky Mountain Spotted Fever along the United States-Mexico Border, 2013-2016.

Emerg Infect Dis 2017 10;23(10):1621-1626

Rocky Mountain spotted fever (RMSF) is an emerging public health concern near the US-Mexico border, where it has resulted in thousands of cases and hundreds of deaths in the past decade. We identified 4 patients who had acquired RMSF in northern Mexico and subsequently died at US healthcare facilities. Two patients sought care in Mexico before being admitted to US-based hospitals. Read More

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http://wwwnc.cdc.gov/eid/article/23/10/17-0309_article.htm
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http://dx.doi.org/10.3201/eid2310.170309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621527PMC
October 2017
28 Reads

Microbial Invasion vs. Tick Immune Regulation.

Front Cell Infect Microbiol 2017 5;7:390. Epub 2017 Sep 5.

Department of Pathobiological Sciences, Louisiana State UniversityBaton Rouge, LA, United States.

Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al. Read More

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http://journal.frontiersin.org/article/10.3389/fcimb.2017.00
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http://dx.doi.org/10.3389/fcimb.2017.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591838PMC
July 2018
34 Reads

Development of an electrochemical immunosensor for the diagnostic testing of spotted fever using synthetic peptides.

Biosens Bioelectron 2018 Feb 16;100:115-121. Epub 2017 Aug 16.

Center of Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation on Neglected Diseases (INCT-IDN), FIOCRUZ, Rio de Janeiro, RJ, Brazil; Laboratory of Experimental and Computational Biochemistry of Pharmaceuticals, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, RJ, Brazil; Department of Cellular and Molecular Biology, Biology Institute, Federal University Fluminense, Niterói, RJ, Brazil.

Spotted fever is a rare acute and multisystemic febrile infectious disease with a mortality rate of ≥50% without adequate antibiotic treatment, and in diagnosed and treated cases, of approximately 2.5%. Currently, the applied test to diagnose this disease is the indirect immunofluorescence reaction, however two samples of paired sera are necessary to confirm the diagnosis, since using only one sample may allow for confusion with cross reactions. Read More

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http://dx.doi.org/10.1016/j.bios.2017.08.029DOI Listing
February 2018
88 Reads

Tick Talk: Tick-borne Diseases of South Dakota.

S D Med 2017 Sep;70(9):410-414

Center for Family Medicine.

In addition to being a nuisance, ticks can carry disease. This article presents a brief review of ticks and associated tick-borne disease relevant to South Dakota and surrounding regions. Tick-borne diseases of special relevance in South Dakota include tularemia, Rocky Mountain spotted fever, and Lyme disease. Read More

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September 2017
6 Reads

Efficacy of sarolaner (Simparic™) against induced infestations of Amblyomma cajennense on dogs.

Parasit Vectors 2017 Aug 17;10(1):390. Epub 2017 Aug 17.

Zoetis, Veterinary Medicine Research and Development, 333 Portage St, Kalamazoo, MI, 49007, USA.

Background: Amblyomma cajennense is the main vector of Rickettsia rickettsii which causes Brazilian spotted fever. This adult tick preferably infests horses and capybaras, but has low host specificity during its immature stages, thus posing a threat to humans and dogs. In this study, the efficacy of sarolaner (Simparic™/Simparica®, Zoetis) when administered once orally to dogs at 2 mg/kg was evaluated against induced infestations of A. Read More

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http://dx.doi.org/10.1186/s13071-017-2324-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559851PMC
August 2017
10 Reads

Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico.

Am J Trop Med Hyg 2017 Sep 19;97(3):795-798. Epub 2017 Jul 19.

Department of Medicine and Health Sciences, University of Sonora, Hermosillo, Mexico.

We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015-2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Read More

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http://dx.doi.org/10.4269/ajtmh.16-0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590584PMC
September 2017
11 Reads

Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma, Ehrlichia, and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee.

Vector Borne Zoonotic Dis 2017 08 9;17(8):527-538. Epub 2017 Jun 9.

3 Department of Forestry, Wildlife and Fisheries, University of Tennessee , Knoxville, Tennessee.

Ehrlichiosis and rickettsiosis are two common bacterial tick-borne diseases in the southeastern United States. Ehrlichiosis is caused by ehrlichiae transmitted by Amblyomma americanum and rickettsiosis is caused by rickettsiae transmitted by Amblyomma maculatum and Dermacentor variabilis. These ticks are common and have overlapping distributions in the region. Read More

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http://dx.doi.org/10.1089/vbz.2016.2091DOI Listing
August 2017
41 Reads

Transmission dynamics and control of Rickettsia rickettsii in populations of Hydrochoerus hydrochaeris and Amblyomma sculptum.

PLoS Negl Trop Dis 2017 Jun 5;11(6):e0005613. Epub 2017 Jun 5.

Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil.

Background: Brazilian Spotted Fever (BSF), caused by the bacterium Rickettsia rickettsii, is the tick-borne disease that generates the largest number of human deaths in the world. In Brazil, the current increase of BSF human cases has been associated with the presence and expansion of capybaras Hydrochoerus hydrochaeris, which act as primary hosts for the tick Amblyomma sculptum, vector of the R. rickettsii in this area. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472331PMC
June 2017
33 Reads

Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014.

N C Med J 2017 May-Jun;78(3):156-163

biostatistics lecturer, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; biostatistician, Rho, Inc., Chapel Hill, North Carolina

Tick bites are a source of illness and disease agents that may lead to morbidity and occasional fatalities in North Carolina. Public health interest in tick-borne illness and disease has increased due to continuing discoveries of tick-borne diseases and their increasing geographic spread and disease incidence. There are no data published on lay individuals with cumulative tick bites and associated illnesses over a period of years. Read More

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http://dx.doi.org/10.18043/ncm.78.3.156DOI Listing
July 2018
28 Reads

The Distinct Transcriptional Response of the Midgut of and Ticks to Correlates to Their Differences in Susceptibility to Infection.

Front Cell Infect Microbiol 2017 28;7:129. Epub 2017 Apr 28.

Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São PauloSão Paulo, Brazil.

is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus and , are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in susceptibility to infection, where is more susceptible than . Read More

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http://dx.doi.org/10.3389/fcimb.2017.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409265PMC
December 2017
44 Reads

An unusual case of sepsis and petechial rash.

JAAPA 2017 May;30(5):30-32

Christina Gardner practices in the ED and VelocityCare Clinics at Carilion Clinic, is director of the Advanced ACP Fellowship in Urgent Care and Rural Health, and is an assistant professor in the PA program at Jefferson College of Health Sciences, all in Roanoke, Va. The author has disclosed no potential conflicts of interest, financial or otherwise.

This article describes a man who presented to the ED in acute distress with signs and symptoms of sepsis, pneumonia, and a new petechial rash on his chest. He was eventually diagnosed with Rocky Mountain spotted fever. Aggressive treatment of sepsis and timely administration of empiric antibiotics were lifesaving in this situation. Read More

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http://dx.doi.org/10.1097/01.JAA.0000513349.15030.59DOI Listing
May 2017
8 Reads

Vector competence of Amblyomma americanum (Acari: Ixodidae) for Rickettsia rickettsii.

Ticks Tick Borne Dis 2017 06 12;8(4):615-622. Epub 2017 Apr 12.

Rickettsial Zoonoses Branch, Centers for Disease Control, Prevention, Atlanta, GA, United States.

Rickettsia rickettsii - the etiologic agent of Rocky Mountain spotted fever (RMSF) - is widely spread across the Americas. In the US, Dermacentor spp. ticks are identified as primary vectors of R. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X163030
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http://dx.doi.org/10.1016/j.ttbdis.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657001PMC
June 2017
15 Reads

Rocky Mountain spotted fever in Mexico: past, present, and future.

Lancet Infect Dis 2017 06 30;17(6):e189-e196. Epub 2017 Mar 30.

National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Rocky Mountain spotted fever, a tick-borne zoonosis caused by Rickettsia rickettsii, is among the most lethal of all infectious diseases in the Americas. In Mexico, the disease was first described during the early 1940s by scientists who carefully documented specific environmental determinants responsible for devastating outbreaks in several communities in the states of Sinaloa, Sonora, Durango, and Coahuila. These investigators also described the pivotal roles of domesticated dogs and Rhipicephalus sanguineus sensu lato (brown dog ticks) as drivers of epidemic levels of Rocky Mountain spotted fever. Read More

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http://dx.doi.org/10.1016/S1473-3099(17)30173-1DOI Listing
June 2017
12 Reads

Rickettsia parkeri in Amblyomma dubitatum ticks in a spotted fever focus from the Brazilian Pampa.

Acta Trop 2017 Jul 28;171:182-185. Epub 2017 Mar 28.

Instituto de Pesquisas Veterinárias Desidério Finamor (IPVDF), Eldorado do Sul, RS, Brazil. Electronic address:

Spotted fever is an acute febrile illness, which is considered severely underreported and misdiagnosed in the Brazilian Pampa, caused by tick-borne Rickettsiae. Here, we report an eco-epidemiological investigation of Rickettsia spp. in ticks from a spotted fever focus in Toropi, southern Brazil. Read More

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http://dx.doi.org/10.1016/j.actatropica.2017.03.028DOI Listing
July 2017
17 Reads

Child Neurology: Rocky Mountain spotted fever encephalitis.

Neurology 2017 03;88(11):e92-e95

From the Departments of Neurology (M.J.B., N.V.) and Medicine (Infectious Disease) and Health Policy (K.C.B.), Vanderbilt University Medical Center; and the Department of Pediatrics, Division of Pediatric Neurology (K.B.L.), and Pediatric Neuroradiology (S.P.), Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, TN.

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http://dx.doi.org/10.1212/WNL.0000000000003722DOI Listing
March 2017
7 Reads

Molecular and serological evidence of flea-associated typhus group and spotted fever group rickettsial infections in Madagascar.

Parasit Vectors 2017 03 4;10(1):125. Epub 2017 Mar 4.

Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.

Background: Rickettsiae are obligate intracellular bacteria responsible for many febrile syndromes around the world, including in sub-Saharan Africa. Vectors of these pathogens include ticks, lice, mites and fleas. In order to assess exposure to flea-associated Rickettsia species in Madagascar, human and small mammal samples from an urban and a rural area, and their associated fleas were tested. Read More

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http://dx.doi.org/10.1186/s13071-017-2061-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336680PMC
March 2017
29 Reads

Unique Strain of Rickettsia parkeri Associated with the Hard Tick Dermacentor parumapertus Neumann in the Western United States.

Appl Environ Microbiol 2017 05 17;83(9). Epub 2017 Apr 17.

Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Starkville, Mississippi, USA.

In 1953, investigators at the Rocky Mountain Laboratories in Hamilton, MT, described the isolation of a spotted fever group (SFGR) species from ticks collected from black-tailed jackrabbits () in northern Nevada. Several decades later, investigators characterized this SFGR (designated the parumapertus agent) by using mouse serotyping methods and determined that it represented a distinct rickettsial serotype closely related to ; nonetheless, the parumapertus agent was not further characterized or studied. To our knowledge, no isolates of the parumapertus agent remain in any rickettsial culture collection, which precludes contemporary phylogenetic placement of this enigmatic SFGR. Read More

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http://aem.asm.org/lookup/doi/10.1128/AEM.03463-16
Publisher Site
http://dx.doi.org/10.1128/AEM.03463-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394329PMC
May 2017
66 Reads

Predictive Factors for Fatal Tick-Borne Spotted Fever in Brazil.

Zoonoses Public Health 2017 11 7;64(7):e44-e50. Epub 2017 Feb 7.

Medical Parasitology and Vector Biology Laboratory, University of Brasília, Brasília, DF, Brazil.

In Brazil, two pathogenic Rickettsia species have been identified causing tick-borne spotted fever (SF). The aetiological agent Rickettsia rickettsii causes serious illness, particularly in the south-eastern region of the country. Moreover, the Rickettsia sp. Read More

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http://doi.wiley.com/10.1111/zph.12345
Publisher Site
http://dx.doi.org/10.1111/zph.12345DOI Listing
November 2017
5 Reads

[Fatal case of rickettsiosis in a toddler from southeastern Mexico].

Arch Argent Pediatr 2017 02;115(1):e5-e8

Laboratorio de Enfermedades Emergentes y Reemergentes, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi" (CIR), Universidad Autónoma de Yucatán, Mérida, Yucatán, México.

Rocky Mountain spotted fever is a disease caused by Rickettsia rickettsii, a bacteria transmitted by infected ticks. It is characterized by fever, exanthema, arthralgias and myalgias; but sometimes its clinical presentation is non specific. Due to its similarities with other exanthematic diseases like dengue or chikungunya, Rocky Mountain spotted fever is not a first line diagnosis, even though countries like Mexico show the ecologic and socioeconomic characteristics that favor its transmission, with a 30% mortality rate among pediatric patients. Read More

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http://dx.doi.org/10.5546/aap.2017.e5DOI Listing
February 2017
4 Reads

Rocky Mountain Spotted Fever.

Authors:
Jennan Phillips

Workplace Health Saf 2017 Jan;65(1):48

1 University of Alabama at Birmingham.

The tick-borne disease Rocky Mountain spotted fever (RMSF) can have deadly outcomes unless treated appropriately, yet nonspecific flu-like symptoms complicate diagnosis. Occupational health nurses must have a high index of suspicion with symptomatic workers and recognize that recent recreational or occupational activities with potential tick exposure may suggest RMSF. Read More

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http://journals.sagepub.com/doi/10.1177/2165079916683711
Publisher Site
http://dx.doi.org/10.1177/2165079916683711DOI Listing
January 2017
8 Reads