1,117 results match your criteria Tick-Borne Diseases Relapsing Fever


Tick-Borne Relapsing Fever in the White Mountains, Arizona, USA, 2013-2018.

Emerg Infect Dis 2019 Apr;25(4):649-653

Tick-borne relapsing fever (TBRF) is a bacterial infection transmitted by tick bites that occurs in several different parts of the world, including the western United States. We describe 6 cases of TBRF acquired in the White Mountains of Arizona, USA, and diagnosed during 2013-2018. All but 1 case-patient had recurrent fever, and some had marked laboratory abnormalities, including leukopenia, thrombocytopenia, hyperbilirubinemia, and elevated aminotransaminases. Read More

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http://dx.doi.org/10.3201/eid2504.181369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433026PMC
April 2019
2 Reads

Meningitis with cranial polyneuritis and cavernous sinus thrombosis by Borrelia crocidurae: First autochthonous case in Europe.

Int J Infect Dis 2019 Feb 25;82:30-32. Epub 2019 Feb 25.

Infectious Diseases Clinic, Department of Medicine, Perugia University, Perugia, Italy.

Borrelia crocidurae is endemic in West Africa, where it represents the leading cause of tick-borne relapsing fever (TBRF). TBRF typically presents with high fever and systemic symptoms, followed by recurrent episodes. Neurological complications may occur during febrile relapses. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.028DOI Listing
February 2019
3 Reads

Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs.

Transbound Emerg Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas.

Tick-borne diseases (TBD), caused by borrelial, rickettsial and babesial pathogens, are common across the United States and can cause severe clinical disease in susceptible hosts, such as domestic dogs. However, there are limited TBD molecular epidemiological reports for dogs in Texas, and none for the non-Lyme borrelial pathogen responsible for causing tick-borne relapsing fever (TBRF). Therefore, data to support the prevalence of TBRF in the canine population is inadequate. Read More

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http://doi.wiley.com/10.1111/tbed.13145
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http://dx.doi.org/10.1111/tbed.13145DOI Listing
February 2019
16 Reads

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.

Clin Cosmet Investig Dermatol 2018 9;11:561-569. Epub 2018 Nov 9.

IGeneX Laboratories, Palo Alto, CA, USA.

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. Read More

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http://dx.doi.org/10.2147/CCID.S184521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233863PMC
November 2018
22 Reads

An immunocompromised mouse model to infect Ixodes scapularis ticks with the relapsing fever spirochete, Borrelia miyamotoi.

Ticks Tick Borne Dis 2019 02 27;10(2):352-359. Epub 2018 Nov 27.

Centers for Disease Control and Prevention, United States. Electronic address:

The hard tick-borne relapsing fever spirochete, Borrelia miyamotoi, has recently gained attention as a cause of human illness, but fundamental aspects of its enzootic maintenance are still poorly understood. Challenges to experimental studies with B. miyamotoi-infected vector ticks include low prevalence of infection in field-collected ticks and seemingly inefficient horizontal transmission from infected immunocompetent rodents to feeding ticks. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.017DOI Listing
February 2019
2 Reads

Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas.

PLoS Negl Trop Dis 2018 10 29;12(10):e0006877. Epub 2018 Oct 29.

Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

Background: In low elevation arid regions throughout the southern United States, Borrelia turicatae is the principal agent of tick-borne relapsing fever. However, endemic foci and the vertebrate hosts involved in the ecology of B. turicatae remain undefined. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006877
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http://dx.doi.org/10.1371/journal.pntd.0006877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224114PMC
October 2018
14 Reads

Relapsing fever in California: a pilot serological study.

Int J Gen Med 2018 21;11:373-382. Epub 2018 Sep 21.

Union Square Medical Associates, San Francisco, CA, USA,

Background: spirochetes are tick-borne Gram-negative bacteria that cause disease in humans and animals. Although many studies have focused on (Bb), the agent of Lyme disease, recent studies have examined the role of Relapsing Fever (RFB) in human disease. In this pilot study, we have evaluated serological reactivity against Bb and RFB in patients residing in California. Read More

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https://www.dovepress.com/relapsing-fever-borrelia-in-califo
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http://dx.doi.org/10.2147/IJGM.S176493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160281PMC
September 2018
18 Reads

A delayed diagnosis: recurrent fever and beta thalassaemia.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

1st Department of Medicine, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Familial Mediterranean fever and beta-thalassaemia are two genetic disorders, with a largely common geographical distribution. However, they have not much else in common, as the first is an autoinflammatory disorder, while the other is a haemoglobinopathy. We describe a patient with known beta-thalassaemia intermedia who presented with recurrent fevers and he was diagnosed with familial Mediterranean fever 2 years later. Read More

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http://dx.doi.org/10.1136/bcr-2018-225802DOI Listing
September 2018
7 Reads

Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia.

Proc Natl Acad Sci U S A 2018 10 24;115(41):10422-10427. Epub 2018 Sep 24.

Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, N-0316 Oslo, Norway;

Louse-borne relapsing fever (LBRF) is known to have killed millions of people over the course of European history and remains a major cause of mortality in parts of the world. Its pathogen, , shares a common vector with global killers such as typhus and plague and is known for its involvement in devastating historical epidemics such as the Irish potato famine. Here, we describe a European and historical genome of , recovered from a 15th century skeleton from Oslo. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1807266115
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http://dx.doi.org/10.1073/pnas.1807266115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187149PMC
October 2018
7 Reads

Borrelia miyamotoi Disease in an Immunocompetent Patient, Western Europe.

Emerg Infect Dis 2018 09;24(9):1770-1772

Borrelia miyamotoi disease is a hard tick-borne relapsing fever illness that occurs across the temperate climate zone. Human B. miyamotoi disease in immunocompetent patients has been described in Russia, North America, and Japan. Read More

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http://dx.doi.org/10.3201/eid2409.180806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106421PMC
September 2018
3 Reads

Case Report and Genetic Sequence Analysis of Candidatus Borrelia kalaharica, Southern Africa.

Emerg Infect Dis 2018 09;24(9):1659-1664

Tickborne relapsing fever caused by Borrelia species is rarely reported in travelers returning from Africa. We report a case of a 71-year-old woman who sought treatment at University Medical Center in Freiburg, Germany, in 2015 with recurrent fever after traveling to southern Africa. We detected spirochetes in Giemsa-stained blood smears. Read More

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http://wwwnc.cdc.gov/eid/article/24/9/17-1381_article.htm
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http://dx.doi.org/10.3201/eid2409.171381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106409PMC
September 2018
2 Reads

Tick-Borne Illnesses in the United States.

Prim Care 2018 Sep 9;45(3):379-391. Epub 2018 Jul 9.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA.

Close interaction with nature can lead to tick-borne illnesses, which are seen most frequently in primary care clinics when patients present symptoms. Considerable morbidity can result from untreated infections. Fortunately, these illnesses are often easily managed when diagnosed early. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00954543183004
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http://dx.doi.org/10.1016/j.pop.2018.05.011DOI Listing
September 2018
36 Reads

Pilot Study of Immunoblots with Recombinant Antigens for Laboratory Diagnosis of Lyme Disease.

Healthcare (Basel) 2018 Aug 14;6(3). Epub 2018 Aug 14.

ID-FISH Technology Inc., 797 San Antonio Road, Palo Alto, CA 94303, USA.

Accurate laboratory diagnosis of Lyme disease (Lyme borreliosis), caused by the spirochete (BB), is difficult and yet important to prevent serious disease. The US Centers for Disease Control and Prevention (CDC) presently recommends a screening test for serum antibodies followed by confirmation with a more specific Western blot (WB) test to detect IgG and IgM antibodies against antigens in whole cell lysates of BB. species related to BB cause tick-borne relapsing fever (TBRF). Read More

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http://dx.doi.org/10.3390/healthcare6030099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163603PMC
August 2018
24 Reads

Lyme Disease in 2018: What Is New (and What Is Not).

JAMA 2018 08;320(7):635-636

Division of Infectious Diseases, New York Medical College, Valhalla.

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http://dx.doi.org/10.1001/jama.2018.10974DOI Listing
August 2018
2 Reads

Case control study: Serological evidence that Borrelia miyamotoi disease occurs nationwide in Japan.

J Infect Chemother 2018 Oct 26;24(10):828-833. Epub 2018 Jul 26.

Department of Bacteriology-I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan. Electronic address:

Since 2011, Borrelia miyamotoi disease (BMD) has been reported in five countries in the northern hemisphere. The causative agent of BMD is transmitted by Ixodes ticks, which are also vectors of Lyme disease borreliae. In this study, we examined 459 cases of clinically suspected Lyme disease (LD group), and found twelve cases that were seropositive for the glycerophosphodiester phosphodiesterase (GlpQ) antigen derived from B. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.06.017DOI Listing
October 2018
2 Reads

Transmission of the relapsing fever spirochete, Borrelia miyamotoi, by single transovarially-infected larval Ixodes scapularis ticks.

Ticks Tick Borne Dis 2018 09 10;9(6):1464-1467. Epub 2018 Jul 10.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, United States. Electronic address:

The relapsing fever spirochete, Borrelia miyamotoi, is increasingly recognized as a cause of human illness (hard tick-borne relapsing fever) in the United States. We previously demonstrated that single nymphs of the blacklegged tick, Ixodes scapularis, can transmit B. miyamotoi to experimental hosts. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135663PMC
September 2018
4 Reads

Relapsing fever in a Moroccan man.

Med Sante Trop 2018 May;28(2):141-143

Hôpital militaire d'instruction Mohamed V, Laboratoire de parasitologie, Faculté de médecine et de pharmacie, Université Mohammed V, Rabat, Maroc.

Tick-borne relapsing fever is a zoonosis caused by spirochetes of the genus Borrelia, transmitted by hematophagous ticks. This life-threatening condition is still misdiagnosed. We report a case of tick-borne relapsing fever in a 54 year-old man in Morocco with a history of hiking, who was hospitalized for an isolated fever. Read More

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http://dx.doi.org/10.1684/mst.2018.0792DOI Listing
May 2018
3 Reads

Tick-borne relapsing fever as a potential veterinary medical problem.

Authors:
Nusirat Elelu

Vet Med Sci 2018 11 26;4(4):271-279. Epub 2018 Jun 26.

Department of Veterinary Public Health and Preventive Medicine, University of Ilorin, Ilorin, Kwara State, Nigeria.

Tick-borne relapsing fever (TBRF) caused by the bacteria Borrelia, is poorly documented in veterinary medicine. Given the widespread presence of the soft tick vectors - Ornithodoros and the recently discovered hard tick vectors, as well as their close association with animal hosts, it is highly likely that infection occurs, but is rarely reported to be of veterinary importance. Sporadic reports of canine infection, some being fatal through to probable cause of abortion in horses have been published. Read More

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http://dx.doi.org/10.1002/vms3.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236141PMC
November 2018

Update on Tick-Borne Bacterial Diseases in Travelers.

Curr Infect Dis Rep 2018 May 22;20(7):17. Epub 2018 May 22.

Aix Marseille University, IRD, AP-HM, SSA, Vecteurs-Infections Tropicales et Méditerranéennes (VITROME), IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.

Purpose Of Review: Ticks are the second most important vectors of infectious diseases after mosquitoes worldwide. The growth of international tourism including in rural and remote places increasingly exposes travelers to tick bite. Our aim was to review the main tick-borne infectious diseases reported in travelers in the past 5 years. Read More

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http://link.springer.com/10.1007/s11908-018-0624-y
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http://dx.doi.org/10.1007/s11908-018-0624-yDOI Listing
May 2018
12 Reads

Shifts in Borrelia burgdorferi (s.l.) geno-species infections in Ixodes ricinus over a 10-year surveillance period in the city of Hanover (Germany) and Borrelia miyamotoi-specific Reverse Line Blot detection.

Parasit Vectors 2018 05 18;11(1):304. Epub 2018 May 18.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hanover, Germany.

Background: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp. Read More

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http://dx.doi.org/10.1186/s13071-018-2882-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960134PMC
May 2018
13 Reads

Evaluation of the protective efficacy of Ornithodoros moubata midgut membrane antigens selected using omics and in silico prediction algorithms.

Ticks Tick Borne Dis 2018 07 30;9(5):1158-1172. Epub 2018 Apr 30.

Parasitología Animal, Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA, CSIC), Cordel de Merinas, 40-52, 37008 Salamanca, Spain. Electronic address:

The African argasid tick Ornithodoros moubata transmits two important pathogens, the African swine fever virus and the spirochete Borrelia duttoni, the cause of human relapsing fever. To date, only conventional control measures such as widespread application of acaricides, strict control measures, and animal movement restrictions have been implemented to confine these diseases. Vaccines against tick infestations have the potential to be among the most efficacious interventions for the management of these diseases. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.04.015DOI Listing
July 2018
5 Reads

Relapsing Fevers: Neglected Tick-Borne Diseases.

Front Cell Infect Microbiol 2018 4;8:98. Epub 2018 Apr 4.

Early Bacterial Virulence: Borrelia Group, Université de Strasbourg, Facultés de Médecine et de Pharmacie, CHRU Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, VBB EA 7290, Strasbourg, France.

Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the family which also contain Lyme disease spirochaetes. Read More

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http://journal.frontiersin.org/article/10.3389/fcimb.2018.00
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http://dx.doi.org/10.3389/fcimb.2018.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893795PMC
April 2019
8 Reads

Dynamics of Spirochetemia and Early PCR Detection of Borrelia miyamotoi.

Emerg Infect Dis 2018 05;24(5):860-867

We investigated whether Borrelia miyamotoi disease can be detected in its early stage by using PCR for borrelial 16S rRNA, which molecule (DNA or RNA) is the best choice for this test, and whether spirochetes are present in blood during the acute phase of B. miyamotoi disease. A total of 473 patients with a suspected tickborne infection in Yekaterinburg, Russia, in 2009, 2010, and 2015 were enrolled in this study. Read More

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http://dx.doi.org/10.3201/eid2405.170829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938775PMC
May 2018
3 Reads

Integrative taxonomy of Afrotropical Ornithodoros (Ornithodoros) (Acari: Ixodida: Argasidae).

Ticks Tick Borne Dis 2018 05 27;9(4):1006-1037. Epub 2018 Mar 27.

Gertrud Theiler Tick Museum, Epidemiology, Parasites and Vectors, Agricultural Research Council - Onderstepoort Veterinary Research, Pretoria, 0110, South Africa; Department of Veterinary Tropical Diseases, University of Pretoria, Pretoria, South Africa; Department of Life and Consumer Sciences, University of South Africa, South Africa. Electronic address:

Afrotropical Ornithodoros (Ornithodoros) ticks are revised based on qualitative morphology of females and nymphs, as well as tarsus I shape outlines of females measured in a geometric morphometric framework. These lines of evidence corroborate lineages based on 16S rRNA nucleotide sequence data. Four previously unrecognized species are described, along with a revived nomen nudum that was previously considered a synonym. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.03.024DOI Listing
May 2018
8 Reads

Primordial origin and diversification of plasmids in Lyme disease agent bacteria.

BMC Genomics 2018 03 27;19(1):218. Epub 2018 Mar 27.

Department of Biology, The Graduate Center, City University of New York, New York, NY, USA.

Background: With approximately one-third of their genomes consisting of linear and circular plasmids, the Lyme disease agent cluster of species has the most complex genomes among known bacteria. We report here a comparative analysis of plasmids in eleven Borreliella (also known as Borrelia burgdorferi sensu lato) species.

Results: We sequenced the complete genomes of two B. Read More

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http://dx.doi.org/10.1186/s12864-018-4597-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870499PMC
March 2018
5 Reads

Isolation and molecular characterization of a relapsing fever Borrelia recovered from Ornithodoros rudis in Brazil.

Ticks Tick Borne Dis 2018 05 9;9(4):864-871. Epub 2018 Mar 9.

Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo, SP, 05508-270, Brazil.

In South America, early reports from more than 50 years ago incriminated Ornithodoros rudis as vector of Borrelia venezuelensis, an agent of tick-borne relapsing fever (TBRF). Herein we report the rediscovery of O. rudis by means of morphological, biological and molecular analyses, which also comprise the first report of this tick species in Brazil. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173057
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http://dx.doi.org/10.1016/j.ttbdis.2018.03.008DOI Listing
May 2018
7 Reads

First detection of Borrelia miyamotoi in Ixodes ricinus ticks from northern Italy.

Parasit Vectors 2018 03 20;11(1):130. Epub 2018 Mar 20.

Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.

Background: Borrelia miyamotoi is a spirochete transmitted by several ixodid tick species. It causes a relapsing fever in humans and is currently considered as an emerging pathogen. In Europe, B. Read More

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http://dx.doi.org/10.1186/s13071-018-2713-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859684PMC
March 2018
9 Reads

The Complement Binding and Inhibitory Protein CbiA of Degrades Extracellular Matrix Components by Interacting with Plasmin(ogen).

Front Cell Infect Microbiol 2018 2;8:23. Epub 2018 Feb 2.

Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt, Germany.

The emerging relapsing fever spirochete (.) is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spirochetes resistant to complement-mediated lysis. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801413PMC
January 2019
11 Reads

Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks.

Authors:
Lars Eisen

Ticks Tick Borne Dis 2018 03 31;9(3):535-542. Epub 2018 Jan 31.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156, Rampart Road, Fort Collins, CO 80521, United States. Electronic address:

The blacklegged tick, Ixodes scapularis, is the primary vector to humans in the eastern United States of the deer tick virus lineage of Powassan virus (Powassan virus disease); the protozoan parasite Babesia microti (babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum (anaplasmosis), Borrelia burgdorferi and Borrelia mayonii (Lyme disease), Borrelia miyamotoi (relapsing fever-like illness, named Borrelia miyamotoi disease), and Ehrlichia muris eauclairensis (a minor causative agent of ehrlichiosis). With the notable exception of Powassan virus, which can be transmitted within minutes after attachment by an infected tick, there is no doubt that the risk of transmission of other I. scapularis-borne pathogens, including Lyme disease spirochetes, increases with the length of time (number of days) infected ticks are allowed to remain attached. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173041
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http://dx.doi.org/10.1016/j.ttbdis.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857464PMC
March 2018
35 Reads

Amblyomma americanum (Acari: Ixodidae) Ticks Are Not Vectors of the Lyme Disease Agent, Borrelia burgdorferi (Spirocheatales: Spirochaetaceae): A Review of the Evidence.

J Med Entomol 2018 May;55(3):501-514

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO.

In the early 1980s, Ixodes spp. ticks were implicated as the key North American vectors of Borrelia burgdorferi (Johnson, Schmid, Hyde, Steigerwalt and Brenner) (Spirocheatales: Spirochaetaceae), the etiological agent of Lyme disease. Concurrently, other human-biting tick species were investigated as potential B. Read More

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http://dx.doi.org/10.1093/jme/tjx250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459681PMC
May 2018
9 Reads

Un diagnostic de borréliose sur frottis sanguin.

Ann Biol Clin (Paris) 2018 Jan;76(1):118-119

Service de bactériologie, CHU Amiens-Picardie, Amiens, France.

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http://dx.doi.org/10.1684/abc.2017.1320DOI Listing
January 2018
2 Reads

The dynamics of vector-borne relapsing diseases.

Math Biosci 2018 03 12;297:32-42. Epub 2018 Jan 12.

University of Montana, USA.

In this paper, we describe the dynamics of a vector-borne relapsing disease, such as tick-borne relapsing fever, using the methods of compartmental models. After some motivation and model description we provide a proof of a conjectured general form of the reproductive ratio R, which is the average number of new infections produced by a single infected individual. A disease free equilibrium undergoes a bifurcation at R=1 and we show that for an arbitrary number of relapses it is a transcritical bifurcation with a single branch of endemic equilibria that is locally asymptotically stable for R sufficiently close to 1. Read More

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http://dx.doi.org/10.1016/j.mbs.2018.01.001DOI Listing
March 2018
7 Reads

A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan.

Ticks Tick Borne Dis 2018 03 28;9(3):465-470. Epub 2017 Dec 28.

Department of Bacteriology-1, National Institute of Infectious Disease, Tokyo, Japan. Electronic address:

A relapsing fever group Borrelia sp. was detected from the blood of wild deer (Cervus nippon) in Japan. The Borrelia sp. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2017.12.016DOI Listing
March 2018
4 Reads

Borrelia persica infection in rock hyraxes.

Ticks Tick Borne Dis 2018 02 9;9(2):382-388. Epub 2017 Dec 9.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot Israel. Electronic address:

Tick-borne relapsing fever (TBRF) is an acute infectious disease caused by arthropod-borne spirochetes of the genus Borrelia and characterized by recurrent episodes of fever. Borrelia persica, the causative agent of this disease in Israel, is transmitted by the argasid tick Ornithodoros tholozani. There is little information about the maintenance and possible vertebrate reservoirs of B. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2017.12.003DOI Listing
February 2018
9 Reads

Spatial multi-criteria decision analysis for modelling suitable habitats of Ornithodoros soft ticks in the Western Palearctic region.

Vet Parasitol 2018 Jan 2;249:2-16. Epub 2017 Nov 2.

Georges Lemaitre Earth and Climate Research Centre, Earth and Life Institute, Université Catholique de Louvain (UCL), Louvain-La-Neuve, Belgium; Fonds de la Recherche Scientifique F.R.S. (FNRS), Brussels, Belgium. Electronic address:

Ticks are economically and medically important ectoparasites due to the injuries inflicted through their bite, and their ability to transmit pathogens to humans, livestock, and wildlife. Whereas hard ticks have been intensively studied, little is known about soft ticks, even though they can also transmit pathogens, including African Swine Fever Virus (ASFV) affecting domestic and wild suids or Borrelia bacteria causing tick-borne relapsing fever (TBRF) in humans. We thus developed a regional model to identify suitable spatial areas for a community of nine Ornithodoros tick species (O. Read More

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http://dx.doi.org/10.1016/j.vetpar.2017.10.022DOI Listing
January 2018
13 Reads

Surveillance for and Discovery of Borrelia Species in US Patients Suspected of Tickborne Illness.

Clin Infect Dis 2018 Jun;66(12):1864-1871

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado.

Background: Tick-transmitted Borrelia fall into 2 heterogeneous bacterial complexes comprised of multiple species, the relapsing fever (RF) group and the Borrelia burgdorferi sensu lato group, which are the causative agents of Lyme borreliosis (LB), the most common tickborne disease in the Northern Hemisphere. Geographic expansion of LB in the United States and discovery of emerging Borrelia pathogens underscores the importance of surveillance for disease-causing Borrelia.

Methods: De-identified clinical specimens, submitted by providers throughout the United States, for patients suspected of LB, anaplasmosis, ehrlichiosis, or babesiosis were screened using a Borrelia genus-level TaqMan polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1093/cid/cix1107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985202PMC
June 2018
17 Reads

A historical snapshot of Ixodes scapularis-borne pathogens in New Jersey ticks reflects a changing disease landscape.

Ticks Tick Borne Dis 2018 02 15;9(2):418-426. Epub 2017 Dec 15.

Tick-Borne Disease Program, Monmouth County Mosquito Control Division, Tinton Falls, NJ, USA; Center for Vector Biology, Rutgers University, New Brunswick, NJ, USA.

Historical specimens, when available, can provide new insight into the distribution and evolution of pathogens that may not be discernible from more recent samples. We used ticks collected from hunter-killed white-tailed deer in New Jersey in 2002 to examine the prevalence and distribution of four pathogens transmitted by Ixodes scapularis, the blacklegged tick. Infection with Borrelia burgdorferi sensu stricto, Babesia microti, and Anaplasma phagocytophilum (the agents of Lyme disease, human babesiosis, and human granulocytic anaplasmosis, respectively) was highest in the Coastal Plain and lowest in the northwestern Skylands region. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2017.12.009DOI Listing
February 2018
13 Reads

Molecular identification of Borrelia spirochetes in questing Ixodes ricinus from northwestern Spain.

Parasit Vectors 2017 Dec 20;10(1):615. Epub 2017 Dec 20.

Departamento de Patología Animal (Grupo INVESAGA), Facultad de Veterinaria, Universidade de Santiago de Compostela, Lugo, Spain.

Background: Ixodes ricinus, the predominant tick species in Europe, can transmit the causative agents of important human diseases such as Lyme borreliosis (LB), caused by Borrelia spirochetes. In northern Spain, LB is considered endemic; recently, a significant increase of the annual incidence of LB was reported in the northwestern (NW) region.

Methods: In order to provide information on the prevalence of Borrelia spp. Read More

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http://dx.doi.org/10.1186/s13071-017-2574-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738910PMC
December 2017
20 Reads

[Clinical presentation of Ixodes tick-borne borreliosis caused by Borrelia miyamotoi in the context of an immune response to the pathogen].

Ter Arkh 2017;89(11):35-43

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia.

Ixodes tick-borne borreliosis caused by Borrelia miyamotoi (ITBB-BM) is a previously unknown infectious disease discovered in Russia.

Aim: The present study continues the investigation of the clinical features of ITBB-BM in the context of an immune system-pathogen interaction.

Subjects And Methods: The study enrolled 117 patients with ITBB-BM and a comparison group of 71 patients with Lyme disease (LD) that is ITBB with erythema migrans. Read More

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http://dx.doi.org/10.17116/terarkh2017891135-43DOI Listing
March 2018
3 Reads

Cis-acting DNA elements flanking the variable major protein expression site of Borrelia hermsii are required for murine persistence.

Microbiologyopen 2018 06 17;7(3):e00569. Epub 2017 Dec 17.

Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, USA.

In Borrelia hermsii, antigenic variation occurs as a result of a nonreciprocal gene conversion event that places one of ~60 silent variable major protein genes downstream of a single, transcriptionally active promoter. The upstream homology sequence (UHS) and downstream homology sequence (DHS) are two putative cis-acting DNA elements that have been predicted to serve as crossover points for homologous recombination. In this report, a targeted deletion/in cis complementation technique was used to directly evaluate the role for these elements in antigenic switching. Read More

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http://doi.wiley.com/10.1002/mbo3.569
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http://dx.doi.org/10.1002/mbo3.569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011951PMC
June 2018
7 Reads

Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs.

PLoS One 2017 12;12(12):e0189786. Epub 2017 Dec 12.

Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, United States of America.

Tick-Borne Relapsing Fever (TBRF) is caused by spirochetes in the genus Borrelia. Very limited information exists on the incidence of this disease in humans and domestic dogs in the United States. The main objective of this study is to evaluate exposure of dogs to Borrelia turicatae, a causative agent of TBRF, in Texas. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189786PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726638PMC
January 2018
6 Reads

Borrelia miyamotoi: Should this pathogen be considered for the diagnosis of tick-borne infectious diseases in Spain?

Enferm Infecc Microbiol Clin 2018 11 26;36(9):568-571. Epub 2017 Nov 26.

Centro de Rickettsiosis y Enfermedades Transmitidas por Artrópodos Vectores, Departamento de Enfermedades Infecciosas, Hospital San Pedro-CIBIR, Logroño (La Rioja), Spain. Electronic address:

Introduction: Borrelia miyamotoi is a tick-borne pathogen belonging to the relapsing fever group. It had not been reported from Spain, but its wide distribution and the presence of the tick-vector (Ixodes ricinus) made us suspect its circulation. The aim of this study was to investigate the presence of Borrelia spp. Read More

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http://dx.doi.org/10.1016/j.eimc.2017.10.020DOI Listing
November 2018
10 Reads

Conspecific hyperparasitism: An alternative route for Borrelia hermsii transmission by the tick Ornithodoros hermsi.

Ticks Tick Borne Dis 2018 02 21;9(2):334-339. Epub 2017 Nov 21.

Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT, United States.

Ixodid and argasid ticks may hyperparasitize other individuals of their own species to acquire a blood meal, however most accounts are based on single observations and the behavior has rarely been studied. While maintaining laboratory colonies of Ornithodoros species, we noticed that unfed ticks occasionally fed on other ticks that were feeding on mice, and unfed ticks parasitized engorged ticks when confined together in tubes. Therefore, we investigated hyperparasitism by Ornithodoros hermsi and the ability of these ticks to acquire and transmit the relapsing fever spirochete Borrelia hermsii when feeding on other ticks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X173041
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http://dx.doi.org/10.1016/j.ttbdis.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803302PMC
February 2018
12 Reads

Colony formation in solid medium by the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae.

Ticks Tick Borne Dis 2018 02 12;9(2):281-287. Epub 2017 Nov 12.

Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Electronic address:

Relapsing fever (RF) in North America is caused primarily by the spirochete Borrelia hermsii and is associated with the bite of its tick vector Ornithodoros hermsi. Although this spirochete was known long before the discovery of the Lyme disease (LD) spirochete, Borrelia burgdorferi, basic methods to facilitate the study of B. hermsii have lagged behind. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803322PMC
February 2018
24 Reads

Detection of relapsing fever Borrelia spp., Bartonella spp. and Anaplasmataceae bacteria in argasid ticks in Algeria.

PLoS Negl Trop Dis 2017 Nov 16;11(11):e0006064. Epub 2017 Nov 16.

Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix Marseille Université, UM63, CNRS 7278, IRD 198, Inserm 1095, AP-HM, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.

Background: Argasid ticks (soft ticks) are blood-feeding arthropods that can parasitize rodents, birds, humans, livestock and companion animals. Ticks of the Ornithodoros genus are known to be vectors of relapsing fever borreliosis in humans. In Algeria, little is known about relapsing fever borreliosis and other bacterial pathogens transmitted by argasid ticks. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708834PMC
November 2017
56 Reads

Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America.

PLoS Negl Trop Dis 2017 Oct 30;11(10):e0006047. Epub 2017 Oct 30.

Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.

Tick-borne relapsing fever in western North America is a zoonosis caused by the spirochete bacterium, Borrelia hermsii, which is transmitted by the bite of infected Ornithodoros hermsi ticks. The pathogen is maintained in natural cycles involving small rodent hosts such as chipmunks and tree squirrels, as well as the tick vector. In order for these ticks to establish sustained and viable populations, a narrow set of environmental parameters must exist, primarily moderate temperatures and moderate to high amounts of precipitation. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679642PMC
October 2017
9 Reads

Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa.

Am J Trop Med Hyg 2017 Dec 21;97(6):1669-1672. Epub 2017 Sep 21.

Unité de Recherche sur le Maladies Infectieuses et Tropicales Émergentes (URMITIE) IRD198, CNRS 7278, INSERM 1095, Institute Hospitalo-Universitarie (IHU) Méditerranée-Infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.

We report two cases of louse-borne relapsing fever observed at our Institution in June 2016. Both patients were young asylum seekers from Africa who had recently arrived in Milan, Italy. Notably, direct microscopic examination of peripheral blood smears was repeatedly negative for the presence of spirochetes and the diagnosis, supported by clinical and epidemiologic evidence, required molecular confirmation by polymerase chain reaction amplification of DNA extracted from blood and sequencing of the amplified products. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805056PMC
December 2017
14 Reads

Presence of Borrelia spp. DNA in ticks, but absence of Borrelia spp. and of Leptospira spp. DNA in blood of fever patients in Madagascar.

Acta Trop 2018 Jan 3;177:127-134. Epub 2017 Oct 3.

University Medical Center, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address:

The occurrence of tick-borne relapsing fever and leptospirosis in humans in Madagascar remains unclear despite the presence of their potential vectors and reservoir hosts. We screened 255 Amblyomma variegatum ticks and 148 Rhipicephalus microplus ticks from Zebu cattle in Madagascar for Borrelia-specific DNA. Borrelia spp. Read More

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http://dx.doi.org/10.1016/j.actatropica.2017.10.002DOI Listing
January 2018
28 Reads

Molecular detection of Borrelia burgdorferi sensu lato - An analytical comparison of real-time PCR protocols from five different Scandinavian laboratories.

PLoS One 2017 22;12(9):e0185434. Epub 2017 Sep 22.

Clinical Microbiology, Laboratory Medicine, Region Jönköping County, Sweden.

Introduction: Lyme borreliosis (LB) is the most common tick transmitted disease in Europe. The diagnosis of LB today is based on the patient´s medical history, clinical presentation and laboratory findings. The laboratory diagnostics are mainly based on antibody detection, but in certain conditions molecular detection by polymerase chain reaction (PCR) may serve as a complement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185434PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609768PMC
October 2017
32 Reads