1,173 results match your criteria Tick-Borne Diseases Relapsing Fever


A novel Borrelia species, intermediate between Lyme disease and relapsing fever groups, in neotropical passerine-associated ticks.

Sci Rep 2020 Jun 30;10(1):10596. Epub 2020 Jun 30.

MIVEGEC (Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle), Centre National de la Recherche Scientifique (CNRS) - Institut pour la Recherche et le Développement (IRD) - Université de Montpellier (UM), Montpellier, France.

Lyme disease (LD) and relapsing fevers (RF) are vector-borne diseases caused by bacteria of the Borrelia genus. Here, we report on the widespread infection by a non-described Borrelia species in passerine-associated ticks in tropical rainforests of French Guiana, South America. This novel Borrelia species is common in two tick species, Amblyomma longirostre and A. Read More

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http://dx.doi.org/10.1038/s41598-020-66828-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327063PMC

Presence of Borrelia miyamotoi infection in a highly endemic area of Lyme disease.

Ann Clin Microbiol Antimicrob 2020 May 30;19(1):22. Epub 2020 May 30.

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

A series of cases in the Northeast of the US during 2013-2015 described a new Borrelia species, Borrelia miyamotoi, which is transmitted by the same tick species that transmits Lyme disease and causes a relapsing fever-like illness. The geographic expansion of B. miyamotoi in the US also extends to other Lyme endemic areas such as the Midwestern US. Read More

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http://dx.doi.org/10.1186/s12941-020-00364-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260789PMC

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy.

J Obstet Gynaecol Can 2020 05;42(5):644-653

Halifax, NS.

Objective: Lyme disease is an emerging infection in Canada caused by the bacterium belonging to the Borrelia burgdorferi sensu lato species complex, which is transmitted via the bite of an infected blacklegged tick. Populations of blacklegged ticks continue to expand and are now established in different regions in Canada. It usually takes more than 24 hours of tick attachment to transfer B. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.01.001DOI Listing

A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Sensu Lato Species and Isolate Differentiation.

Front Microbiol 2020 21;11:690. Epub 2020 Apr 21.

Division of Infectious Diseases and Tropical Medicine, University Hospital LMU, Munich, Germany.

The genus comprises vector-borne bacterial pathogens that can severely affect human and animal health. Members of the sensu lato species complex can cause Lyme borreliosis, one of the most common vector-borne diseases in the Northern hemisphere. Besides, members of the relapsing fever group of spirochetes can cause tick-borne relapsing fever in humans and various febrile illnesses in animals in tropical, subtropical and temperate regions. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186393PMC

Rapid clearance of Borrelia burgdorferi from the blood circulation.

Parasit Vectors 2020 Apr 21;13(1):191. Epub 2020 Apr 21.

Bacteriology and Mycology, Institute for Infectious Diseases and Zoonoses, Department of Veterinary Science, Faculty of Veterinary Medicine, LMU Munich, Munich, Germany.

Background: Borrelia burgdorferi is a tick-borne spirochete that causes Lyme borreliosis (LB). After an initial tick bite, it spreads from the deposition site in the dermis to distant tissues of the host. It is generally believed that this spirochete disseminates via the hematogenous route. Read More

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http://dx.doi.org/10.1186/s13071-020-04060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171858PMC

Assessment of Borrelia miyamotoi in febrile patients and ticks in Alsace, an endemic area for Lyme borreliosis in France.

Parasit Vectors 2020 Apr 17;13(1):199. Epub 2020 Apr 17.

University of Strasbourg, Virulence bactérienne précoce UR7290-Lyme borreliosis group, FMTS - CHRU Strasbourg, Institut de Bactériologie, Strasbourg, France.

Background: Borrelia miyamotoi is a relapsing fever Borrelia species transmitted by ticks of the Ixodes ricinus complex. Human disease caused by B. miyamotoi was first described in Russia and later in the USA and Japan. Read More

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http://dx.doi.org/10.1186/s13071-020-04071-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165395PMC

Transovarial transmission of Borrelia spp., Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus under field conditions extrapolated from DNA detection in questing larvae.

Parasit Vectors 2020 Apr 7;13(1):176. Epub 2020 Apr 7.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hanover, Germany.

Background: Ixodes ricinus constitutes the main European vector tick for the Lyme borreliosis pathogen Borrelia burgdorferi (sensu lato), the relapsing fever borrelia Borrelia miyamotoi, as well as Anaplasma phagocytophilum and several Rickettsia species. Under laboratory conditions, a transovarial transmission to the next tick generation is described for Rickettsia spp. and Borrelia spp. Read More

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http://dx.doi.org/10.1186/s13071-020-04049-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140504PMC

Tick-Borne Diseases in the United States.

Clin Chem 2020 Apr;66(4):537-548

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Background: Tick-borne diseases are an important cause of human morbidity and mortality in the United States. The past several decades have witnessed an increase in both the number of recognized tick-borne pathogens and the number of tick-borne disease cases, whereas tick surveys have revealed substantial geographic expansions of tick populations throughout the country. Multiple laboratory testing options exist for diagnosis of tick-borne diseases, including serology, microscopy, and molecular-based methods. Read More

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http://dx.doi.org/10.1093/clinchem/hvaa040DOI Listing

Doxycycline for Prevention of Spirochetal Infections-Status Report.

Authors:
Gary P Wormser

Clin Infect Dis 2020 Mar 11. Epub 2020 Mar 11.

Division of Infectious Diseases, New York Medical College, Valhalla, NY.

Important human infections caused by spirochetal microorganisms include Lyme disease, syphilis, leptospirosis, and tick-borne relapsing fever. Doxycycline prophylactic regimens have been shown to significantly reduce the risk for developing all of these infections in potentially exposed individuals, which is highly clinically relevant since no vaccines to prevent these infections in humans are currently available. Additional data, however, are needed to define more precisely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and syphilis, infections that can be potentially prevented by a single 200 mg dose of doxycycline given within 72 hours post-exposure. Read More

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http://dx.doi.org/10.1093/cid/ciaa240DOI Listing

Transgenic functional complementation with a transmission -associated protein restores spirochete infectivity by tick bite.

Ticks Tick Borne Dis 2020 May 20;11(3):101377. Epub 2020 Jan 20.

Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT, 59840, USA.

The relapsing fever spirochete Borrelia hermsii and the Lyme disease spirochete Borrelia burgdorferi sensu stricto each produces an abundant, orthologous, outer membrane protein, Vtp and OspC, respectively, when transmitted by tick bite. Gene inactivation studies have shown that both proteins are essential for spirochete infectivity when transmitted by their respective tick vectors. Therefore, we transformed a vtp-minus mutant of B. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101377DOI Listing

Borrelia prevalence and species distribution in ticks removed from humans in Germany, 2013-2017.

Ticks Tick Borne Dis 2020 Mar 23;11(2):101363. Epub 2019 Dec 23.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany. Electronic address:

Lyme borreliosis caused by spirochaetes of the Borrelia burgdorferi sensu lato (s.l.) complex is the most common tick-borne disease in Europe. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101363DOI Listing

Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in (Acari: Ixodidae) in Connecticut, USA.

J Parasitol 2020 02;106(1):30-37

Department of Environmental Sciences, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, Connecticut 06511.

is currently known to transmit 7 pathogens responsible for Lyme disease, anaplasmosis, babesiosis, tick-borne relapsing fever, ehrlichiosis, and Powassan encephalitis. can also be colonized by endosymbiotic bacteria including those in the genus of . We screened 459 ticks submitted to the Connecticut Agricultural Experiment Station Tick Testing Laboratory with the objectives to (1) examine differences in infection prevalence of , , , and , (2) evaluate whether prevalence of co-infections occur at the same frequency that would be expected based on single infection, and (3) determine the presence of rickettsial endosymbionts in . Read More

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February 2020

Single dose of Doxycycline for the prevention of TBRF.

Clin Infect Dis 2020 Jan 19. Epub 2020 Jan 19.

Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Israel.

The current post-exposure prophylaxis regimen for Tick Borne Relapsing Fever (TBRF) consists of 5 days Doxycycline. In this observational study of 77 spelunkers at high-risk for TBRF, a single dose of 100 mg Doxycycline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease. Read More

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http://dx.doi.org/10.1093/cid/ciaa034DOI Listing
January 2020
8.886 Impact Factor

A man with recurrent fever, arthritis, and rashes-brucellosis? A case report.

BMC Infect Dis 2020 Jan 7;20(1):18. Epub 2020 Jan 7.

Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, Liaoning Province, China.

Background: We report a rare case of chronic brucellosis accompanied with myelodysplastic syndrome and neutrophilic dermatosis, which to the best of our knowledge, has never been reported.

Case Presentation: A young man was admitted to our hospital complaining of recurrent fever, arthritis, rashes and anemia. He had been diagnosed with brucellosis 6 years prior and treated with multiple courses of antibiotics. Read More

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http://dx.doi.org/10.1186/s12879-019-4746-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947870PMC
January 2020
2.613 Impact Factor

Whole genome sequencing of Borrelia miyamotoi isolate Izh-4: reference for a complex bacterial genome.

BMC Genomics 2020 Jan 6;21(1):16. Epub 2020 Jan 6.

Central Research Institute of Epidemiology, Moscow, 111123, Russia.

Background: The genus Borrelia comprises spirochaetal bacteria maintained in natural transmission cycles by tick vectors and vertebrate reservoir hosts. The main groups are represented by a species complex including the causative agents of Lyme borreliosis and relapsing fever group Borrelia. Borrelia miyamotoi belongs to the relapsing fever group of spirochetes and forms distinct populations in North America, Asia, and Europe. Read More

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http://dx.doi.org/10.1186/s12864-019-6388-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945570PMC
January 2020

Detection of Borrelia crocidurae in a vaginal swab after miscarriage, rural Senegal, Western Africa.

Int J Infect Dis 2020 Feb 19;91:261-263. Epub 2019 Dec 19.

IHU - Méditerranée Infection, Marseille, France; Aix Marseille Université, IRD, AP-HM, MEPHI, Marseille, France. Electronic address:

Tick-borne relapsing fever (TBRF) borreliae are one of the main causes of fever in rural Africa and can cause miscarriages. This article reports Borrelia crocidurae as a probable cause of spontaneous miscarriage, which was detected through vaginal self-sampling. This appears to be the first such report. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.12.020DOI Listing
February 2020

Immunosuppressive effects of sialostatin L1 and L2 isolated from the taiga tick Ixodes persulcatus Schulze.

Ticks Tick Borne Dis 2020 Mar 10;11(2):101332. Epub 2019 Nov 10.

Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Hokkaido, Japan.

Tick saliva contains immunosuppressants which are important to obtain a blood meal and enhance the infectivity of tick-borne pathogens. In Japan, Ixodes persulcatus is a major vector for Lyme borreliosis pathogens, such as Borrelia garinii, as well as for those causing relapsing fever, such as B. miyamotoi. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101332DOI Listing

Presence of diverse Rickettsia spp. and absence of Borrelia burgdorferi sensu lato in ticks in an East Texas forest with reduced tick density associated with controlled burns.

Ticks Tick Borne Dis 2020 Jan 17;11(1):101310. Epub 2019 Oct 17.

College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, 4458 TAMU, College Station, TX 77843-4467, USA. Electronic address:

As tick-borne diseases continue to emerge across the United States, there is need for a better understanding of the tick and pathogen communities in the southern states and of habitat features that influence transmission risk. We surveyed questing and on-host ticks in pine-dominated forests with various fire management regimes in the Sam Houston National Forest, a popular recreation area near Houston, Texas. Four linear transects were established- two with a history of controlled burns, and two unburned. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101310DOI Listing
January 2020

Population structure of Borrelia turcica from Greece and Turkey.

Infect Genet Evol 2020 01 30;77:104050. Epub 2019 Oct 30.

German National Reference Centre for Borrelia, Bavarian Health and Food Safety Authority, Veterinärstr. 2, Oberschleissheim 85764, Germany.

Borrelia turcica, a member of the reptile-associated Borrelia clade, is vectored by Hyalomma aegyptium. The only suggested reservoir hosts of B. turcica are tortoises of the genus Testudo. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.104050DOI Listing
January 2020
3.015 Impact Factor

Host Competency of the Multimammate Rat Demonstrated by Prolonged Spirochetemias with the African Relapsing Fever Spirochete .

Am J Trop Med Hyg 2019 12;101(6):1272-1275

Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana.

African multimammate rats, , are widely distributed in sub-Saharan Africa and live in close association with humans. In West Africa, numerous field studies have shown these animals may be naturally infected with the relapsing fever spirochete , the primary cause of tick-borne relapsing fever in this region of the continent. However, naturally infected individual rats have never been examined over time; therefore, the true host competency of these rats for this spirochete is unknown. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896849PMC
December 2019
1 Read

Reptile-associated Borrelia spp. In Amblyomma ticks, Thailand.

Ticks Tick Borne Dis 2020 Jan 14;11(1):101315. Epub 2019 Oct 14.

Biodiversity Research Cluster, Department of Biology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand; Center of Excellence for Vectors and Vector-Borne Diseases, Faculty of Science, Mahidol University at Salaya, Phutthamonthon 4 Road, Nakhon Pathom, Thailand. Electronic address:

A total of 127 Amblyomma ticks (A. helvolum, A. varanense and A. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101315DOI Listing
January 2020
1 Read

[Meningitis due to infection with Borrelia hispanica].

Ned Tijdschr Geneeskd 2019 10 10;163. Epub 2019 Oct 10.

Elisabeth-TweeSteden Ziekenhuis, afd. Neurologie, Tilburg.

BACKGROUND Tick-borne relapsing fever is a disease that is caused by infection with a Borrelia bacterium, and is transmitted by ticks. This infectious disease is characterised by relapsing episodes of high fever, often accompanied by aspecific symptoms. CASE DESCRIPTION We describe the history of a 20-year-old woman who developed recurrent episodes of fever with headache and vomiting after a holiday in Morocco. Read More

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October 2019
1 Read

Laboratory Blood-Based Testing for Non-Lyme Disease Tick-Borne Infections at a National Reference Laboratory.

Am J Clin Pathol 2020 01;153(1):139-145

Quest Diagnostics, Secaucus, NJ.

Objectives: We evaluated trends in non-Lyme disease tick-borne disease (NLTBI) testing at a national reference laboratory.

Methods: Testing data performed at Quest Diagnostics during 2010 to 2016 were analyzed nationally and at the state level.

Results: Testing and positivity for most NLTBIs increased dramatically from 2010 through 2016 based on testing from a large reference laboratory. Read More

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http://dx.doi.org/10.1093/ajcp/aqz139DOI Listing
January 2020
1 Read

Discovery of the Lyme Disease Agent.

mBio 2019 09 17;10(5). Epub 2019 Sep 17.

Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, New York, USA

A detailed first-hand account of the events leading up to the discovery of the Lyme disease agent has been lacking. Nearly 40 years have elapsed since the discovery of the organism that was named There are thousands of articles in the scientific and medical literature on this organism and the disease that it causes. In the interval since the organism's discovery, however, misconceptions have arisen regarding not only the disease but the discovery itself. Read More

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http://dx.doi.org/10.1128/mBio.02166-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751065PMC
September 2019
6 Reads

Borrelia microti infection in an Italian woman returning from Kyrgyzstan and Tajikistan.

Travel Med Infect Dis 2020 May - Jun;35:101448. Epub 2019 Jul 6.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2019.07.004DOI Listing
July 2019
4 Reads

Borrelia crocidurae tick-borne relapsing fever upon return from Senegal.

Med Mal Infect 2019 11 12;49(8):624-625. Epub 2019 Jun 12.

Service de bactériologie-virologie-hygiène hospitalière, hôpital Bretonneau, CHRU de Tours, 2 boulevard Tonnellé, 37044 Tours, France; Infectiologie et santé publique, INRA, université de Tours, UMR1282, 37380 Nouzilly, France. Electronic address:

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http://dx.doi.org/10.1016/j.medmal.2019.05.005DOI Listing
November 2019
2 Reads

A relapsing fever Borrelia and spotted fever Rickettsia in ticks from an Andean valley, central Chile.

Exp Appl Acarol 2019 Jul 5;78(3):403-420. Epub 2019 Jun 5.

Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.

In humans, emerging infectious diseases are mostly zoonoses with ticks playing an important role as vectors. Tick-borne relapsing fever Borrelia and spotted fever Rickettsia occur in endemic foci along tropical and subtropical regions of the globe. However, both are widely neglected etiologic agents. Read More

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http://dx.doi.org/10.1007/s10493-019-00389-xDOI Listing
July 2019
15 Reads

Evaluating the risk of tick-borne relapsing fever among occupational cavers-Austin, TX, 2017.

Zoonoses Public Health 2019 09 31;66(6):579-586. Epub 2019 May 31.

Centers for Disease Control and Prevention, Fort Collins, Colorado.

Tick-borne relapsing fever (TBRF) is a potentially serious spirochetal infection caused by certain species of Borrelia and acquired through the bite of Ornithodoros ticks. In 2017, Austin Public Health, Austin, TX, identified five cases of febrile illness among employees who worked in caves. A cross-sectional serosurvey and interview were conducted for 44 employees at eight organizations that conduct cave-related work. Read More

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http://dx.doi.org/10.1111/zph.12588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042895PMC
September 2019
18 Reads

Single Core Genome Sequencing for Detection of both Sensu Lato and Relapsing Fever Borrelia Species.

Int J Environ Res Public Health 2019 05 20;16(10). Epub 2019 May 20.

Department of medicine, University College Dublin, D04 V1W8 Dublin, Ireland.

Lyme disease, initially described as Lyme arthritis, was reported before nucleic-acid based detection technologies were available. The most widely used diagnostic tests for Lyme disease are based on the serologic detection of antibodies produced against antigens derived from a single strain of . The poor diagnostic accuracy of serological tests early in the infection process has been noted most recently in the 2018 Report to Congress issued by the U. Read More

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http://dx.doi.org/10.3390/ijerph16101779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571920PMC
May 2019
9 Reads

Questing Ixodes ricinus ticks (Acari, Ixodidae) as a vector of Borrelia burgdorferi sensu lato and Borrelia miyamotoi in an urban area of north-eastern Poland.

Exp Appl Acarol 2019 May 17;78(1):113-126. Epub 2019 May 17.

Department of Medical Biology, Faculty of Health Sciences, University of Warmia and Mazury in Olsztyn, Zolnierska 14c, 10-561, Olsztyn, Poland.

Green areas located within large cities, as natural ecotypes, are a convenient habitat for ticks and their use as recreational areas is associated with the potential risk of acquiring tick-borne diseases. This study estimated the I. ricinus tick density, prevalence of infection with Borrelia species and the diversity of these bacteria in a green urban area (Olsztyn) of north-eastern Poland, an endemic region of tick-borne diseases. Read More

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http://dx.doi.org/10.1007/s10493-019-00379-zDOI Listing
May 2019
9 Reads

A new on the block: - a human health risk?

Euro Surveill 2019 May;24(18)

European Centre for Disease Prevention and Control, Solna, Sweden.

Background clusters phylogenetically among relapsing fever borreliae, but is transmitted by hard ticks. Recent recognition as a human pathogen has intensified research into its ecology and pathogenic potential.AimsWe aimed to provide a timely critical integrative evaluation of our knowledge on , to assess its public health relevance and guide future research. Read More

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https://www.eurosurveillance.org/content/10.2807/1560-7917.E
Publisher Site
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.18.1800170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505184PMC
May 2019
22 Reads

Citizen science informs human-tick exposure in the Northeastern United States.

Int J Health Geogr 2019 05 7;18(1). Epub 2019 May 7.

Department of Biological Sciences, Northern Arizona University, 617 S. Beaver Street, Flagstaff, AZ, 86011, USA.

Background: Tick-borne disease is the result of spillover of pathogens into the human population. Traditionally, literature has focused on characterization of tick-borne disease pathogens and ticks in their sylvatic cycles. A limited amount of research has focused on human-tick exposure in this system, especially in the Northeastern United States. Read More

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https://ij-healthgeographics.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s12942-019-0173-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505254PMC
May 2019
26 Reads

Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Sonora, Mexico.

PLoS Negl Trop Dis 2019 04 11;13(4):e0007215. Epub 2019 Apr 11.

Laboratorio de Genética Microbiana, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.

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http://dx.doi.org/10.1371/journal.pntd.0007215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459496PMC
April 2019
9 Reads

Testing the Competence of Bed Bugs for the Transmission of , the Agent of Relapsing Fever.

Am J Trop Med Hyg 2019 06;100(6):1407-1412

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.

In recent years, bed bugs have reappeared in greater numbers, more frequently, and are biting humans in many new geographic areas. Infestations by these hematophagous insects are rapidly increasing worldwide. , a spirochete bacterium, is the etiologic agent of louse-borne relapsing fever. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553891PMC
June 2019
11 Reads

Tick-Borne Relapsing Fever in the White Mountains, Arizona, USA, 2013-2018.

Emerg Infect Dis 2019 04;25(4):649-653

Tick-borne relapsing fever (TBRF) is a bacterial infection transmitted by tick bites that occurs in several different parts of the world, including the western United States. We describe 6 cases of TBRF acquired in the White Mountains of Arizona, USA, and diagnosed during 2013-2018. All but 1 case-patient had recurrent fever, and some had marked laboratory abnormalities, including leukopenia, thrombocytopenia, hyperbilirubinemia, and elevated aminotransaminases. Read More

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http://dx.doi.org/10.3201/eid2504.181369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433026PMC
April 2019
12 Reads

Louse-borne relapsing fever (Borrelia recurrentis infection).

Authors:
David A Warrell

Epidemiol Infect 2019 01;147:e106

Nuffield Department of Clinical Medicine,University of Oxford,Oxford,UK.

Louse-borne relapsing fever (LBRF) is an epidemic disease with a fascinating history from Hippocrates' times, through the 6th century 'Yellow Plague', to epidemics in Ireland, Scotland and England in the 19th century and two large Afro-Middle Eastern pandemics in the 20th century. An endemic focus persists in Ethiopia and adjacent territories in the Horn of Africa. Since 2015, awareness of LBRF in Europe, as a re-emerging disease, has been increased dramatically by the discovery of this infection in dozens of refugees arriving from Africa. Read More

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http://dx.doi.org/10.1017/S0950268819000116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518520PMC
January 2019
35 Reads

Meningitis with cranial polyneuritis and cavernous sinus thrombosis by Borrelia crocidurae: First autochthonous case in Europe.

Int J Infect Dis 2019 May 25;82:30-32. Epub 2019 Feb 25.

Infectious Diseases Clinic, Department of Medicine, Perugia University, Perugia, Italy.

Borrelia crocidurae is endemic in West Africa, where it represents the leading cause of tick-borne relapsing fever (TBRF). TBRF typically presents with high fever and systemic symptoms, followed by recurrent episodes. Neurological complications may occur during febrile relapses. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.028DOI Listing
May 2019
14 Reads

Values of diagnostic tests for the various species of spirochetes.

Med Mal Infect 2019 Mar 11;49(2):102-111. Epub 2019 Feb 11.

IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Aix Marseille Université, 13005 Marseille, France.

Bacteria of the Borrelia burgdorferi sensu lato complex, responsible for Lyme disease, are members of the spirochetes phylum. Diagnostic difficulties of Lyme disease are partly due to the characteristics of spirochetes as their culture is tedious or even impossible for some of them. We performed a literature review to assess the value of the various diagnostic tests of spirochetes infections of medical interest such as Lyme borreliosis, relapsing fever borreliae, syphilis, and leptospirosis. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.009DOI Listing
March 2019
11 Reads

Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs.

Transbound Emerg Dis 2019 May 6;66(3):1291-1300. Epub 2019 Mar 6.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas.

Tick-borne diseases (TBD), caused by borrelial, rickettsial and babesial pathogens, are common across the United States and can cause severe clinical disease in susceptible hosts, such as domestic dogs. However, there are limited TBD molecular epidemiological reports for dogs in Texas, and none for the non-Lyme borrelial pathogen responsible for causing tick-borne relapsing fever (TBRF). Therefore, data to support the prevalence of TBRF in the canine population is inadequate. Read More

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http://doi.wiley.com/10.1111/tbed.13145
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http://dx.doi.org/10.1111/tbed.13145DOI Listing
May 2019
42 Reads

Repellency effect of flumethrin pour-on formulation against vectors of Crimean-Congo haemorrhagic fever.

East Mediterr Health J 2019 Jan 23;24(11):1082-1087. Epub 2019 Jan 23.

Department of Medical Entomology and Vector Control, School of Public Health and National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Background: Ticks are able to transmit important diseases to humans, including Rocky Mountain spotted fever, Q fever, Crimean-Congo haemorrhagic fever, summer Russian encephalitis, and relapsing fever.

Aims: To determine the repellency effect of 1% flumethrin pour-on formulation against hard ticks.

Methods: The concentration of flumethrin pour-on formulation was 1 mg/10 kg body weight and was administered on the dorsal midline from the head to the base of the tail. Read More

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http://dx.doi.org/10.26719/emhj.18.004DOI Listing
January 2019
13 Reads

Immunological Responses to the Relapsing Fever Spirochete in Infected Rhesus Macaques: Implications for Pathogenesis and Diagnosis.

Infect Immun 2019 04 25;87(4). Epub 2019 Mar 25.

Department of Pediatrics, National School of Tropical Medicine, Houston, Texas, USA.

The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Read More

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http://dx.doi.org/10.1128/IAI.00900-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434134PMC
April 2019
10 Reads

Blood Smears Have Poor Sensitivity for Confirming Borrelia miyamotoi Disease.

J Clin Microbiol 2019 03 27;57(3). Epub 2019 Feb 27.

Imugen, Inc., Norwood, Massachusetts, USA.

disease (BMD) is a newly recognized borreliosis that is cotransmitted by ticks wherever Lyme disease is zoonotic. Unlike , the agent of Lyme disease, is closely related to relapsing fever spirochetes, such as Some authors have suggested that the disease caused by should be considered a hard-tick-transmitted relapsing fever, and thus, the main mode of confirming a diagnosis for that infection, microscopy to analyze a blood smear, may have clinical utility. To determine whether blood smears may detect in the blood of acute BMD patients, we made standard malariological thick smears from anticoagulated blood samples that were previously determined to contain this agent (by PCR) and analyzed them for morphological evidence of spirochetes. Read More

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http://dx.doi.org/10.1128/JCM.01468-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425185PMC
March 2019
5 Reads

The genus Borrelia reloaded.

PLoS One 2018 26;13(12):e0208432. Epub 2018 Dec 26.

Bavarian Health and Food Safety Authority and National Reference Center for Borrelia, Oberschleissheim, Germany.

The genus Borrelia, originally described by Swellengrebel in 1907, contains tick- or louse-transmitted spirochetes belonging to the relapsing fever (RF) group of spirochetes, the Lyme borreliosis (LB) group of spirochetes and spirochetes that form intermittent clades. In 2014 it was proposed that the genus Borrelia should be separated into two genera; Borrelia Swellengrebel 1907 emend. Adeolu and Gupta 2014 containing RF spirochetes and Borreliella Adeolu and Gupta 2014 containing LB group of spirochetes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208432PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306154PMC
May 2019
8 Reads

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.

Clin Cosmet Investig Dermatol 2018 9;11:561-569. Epub 2018 Nov 9.

IGeneX Laboratories, Palo Alto, CA, USA.

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. Read More

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http://dx.doi.org/10.2147/CCID.S184521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233863PMC
November 2018
44 Reads

An immunocompromised mouse model to infect Ixodes scapularis ticks with the relapsing fever spirochete, Borrelia miyamotoi.

Ticks Tick Borne Dis 2019 02 27;10(2):352-359. Epub 2018 Nov 27.

Centers for Disease Control and Prevention, United States. Electronic address:

The hard tick-borne relapsing fever spirochete, Borrelia miyamotoi, has recently gained attention as a cause of human illness, but fundamental aspects of its enzootic maintenance are still poorly understood. Challenges to experimental studies with B. miyamotoi-infected vector ticks include low prevalence of infection in field-collected ticks and seemingly inefficient horizontal transmission from infected immunocompetent rodents to feeding ticks. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.017DOI Listing
February 2019
10 Reads

The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector.

Cell Microbiol 2019 02 4;21(2):e12987. Epub 2019 Jan 4.

Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.

The relapsing fever spirochete Borrelia turicatae possesses a complex life cycle in its soft-bodied tick vector, Ornithodoros turicata. Spirochetes enter the tick midgut during a blood meal, and, during the following weeks, spirochetes disseminate throughout O. turicata. Read More

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http://dx.doi.org/10.1111/cmi.12987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454574PMC
February 2019
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Predicting the ligand-binding properties of Borrelia burgdorferi s.s. Bmp proteins in light of the conserved features of related Borrelia proteins.

J Theor Biol 2019 02 9;462:97-108. Epub 2018 Nov 9.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6 A, Turku FI-20520, Finland. Electronic address:

Bacteria of the genus Borrelia cause vector-borne infections like the most important hard tick-borne disease in the northern hemisphere, Lyme borreliosis (LB), and soft tick or louse transmitted relapsing fevers (RF), prevalent in temperate and tropical areas. Borrelia burgdorferi sensu lato (s.l. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225193183055
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http://dx.doi.org/10.1016/j.jtbi.2018.11.004DOI Listing
February 2019
13 Reads

Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas.

PLoS Negl Trop Dis 2018 10 29;12(10):e0006877. Epub 2018 Oct 29.

Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

Background: In low elevation arid regions throughout the southern United States, Borrelia turicatae is the principal agent of tick-borne relapsing fever. However, endemic foci and the vertebrate hosts involved in the ecology of B. turicatae remain undefined. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006877
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http://dx.doi.org/10.1371/journal.pntd.0006877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224114PMC
October 2018
35 Reads

Relapsing fever in California: a pilot serological study.

Int J Gen Med 2018 21;11:373-382. Epub 2018 Sep 21.

Union Square Medical Associates, San Francisco, CA, USA,

Background: spirochetes are tick-borne Gram-negative bacteria that cause disease in humans and animals. Although many studies have focused on (Bb), the agent of Lyme disease, recent studies have examined the role of Relapsing Fever (RFB) in human disease. In this pilot study, we have evaluated serological reactivity against Bb and RFB in patients residing in California. Read More

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https://www.dovepress.com/relapsing-fever-borrelia-in-califo
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http://dx.doi.org/10.2147/IJGM.S176493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160281PMC
September 2018
32 Reads

A delayed diagnosis: recurrent fever and beta thalassaemia.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

1st Department of Medicine, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Familial Mediterranean fever and beta-thalassaemia are two genetic disorders, with a largely common geographical distribution. However, they have not much else in common, as the first is an autoinflammatory disorder, while the other is a haemoglobinopathy. We describe a patient with known beta-thalassaemia intermedia who presented with recurrent fevers and he was diagnosed with familial Mediterranean fever 2 years later. Read More

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http://dx.doi.org/10.1136/bcr-2018-225802DOI Listing
September 2018
17 Reads