1,234 results match your criteria Tick-Borne Diseases Relapsing Fever


Borreliosis Transmission from Ticks Associated with Desert Tortoise Burrows: Examples of Tick-Borne Relapsing Fever in the Mojave Desert.

Vector Borne Zoonotic Dis 2021 Jun 18. Epub 2021 Jun 18.

Department of Agriculture, Veterinary and Rangeland Sciences, University of Nevada-Reno, Reno, Nevada, USA.

Ticks transmit pathogens and parasitize wildlife in turn causing zoonotic diseases in many ecosystems. Argasid ticks, such as spp., harbor and transmit spp. Read More

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Diversity of microorganisms in Hyalomma aegyptium collected from spur-thighed tortoise (Testudo graeca) in North Africa and Anatolia.

Transbound Emerg Dis 2021 Jun 14. Epub 2021 Jun 14.

CIBIO/InBIO - Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Vairão, Portugal.

Ticks carry a diverse community of microorganisms including non-pathogenic symbionts, commensals, and pathogens, such as viruses, bacteria, protozoans, and fungi. The assessment of tick-borne microorganisms (TBM) in tortoises and their ticks is essential to understand their eco-epidemiology, and to map and monitor potential pathogens to humans and other animals. The aim of this study was to characterize the diversity of microorganisms found in ticks collected from the spur-thighed tortoise (Testudo graeca) in North Africa and Anatolia. Read More

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The evolution of hard tick-borne relapsing fever borreliae is correlated with vector species rather than geographical distance.

BMC Ecol Evol 2021 05 31;21(1):105. Epub 2021 May 31.

Joint Graduate School of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.

Background: Relapsing fever (RF) borreliae are arthropod-borne spirochetes and some of them cause human diseases, which are characterized by relapsing or recurring episodes of fever. Recently, it has been classified into two groups: soft tick-borne RF (STRF) borreliae and hard tick-borne RF (HTRF) borreliae. STRF borreliae include classical RF agents and HTRF borreliae, the latter of which include B. Read More

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Endogenous and Borrowed Proteolytic Activity in the .

Microbiol Mol Biol Rev 2021 May 12;85(2). Epub 2021 May 12.

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

SUMMARYThe spp. are tick-borne pathogenic spirochetes that include the agents of Lyme disease and relapsing fever. As part of their life cycle, the spirochetes traffic between the tick vector and the vertebrate host, which requires significant physiological changes and remodeling of their outer membranes and proteome. Read More

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Detection of Genetic Variability in Borrelia miyamotoi (Spirochaetales: Spirochaetaceae) Between and Within the Eastern and Western United States.

J Med Entomol 2021 May 6. Epub 2021 May 6.

Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.

Borrelia miyamotoi is a hard tick-associated relapsing fever spirochete that is geographically widespread in Ixodes spp. (Acari: Ixodidae) ticks, but typically occurs at low prevalence. Genetic variability has been described among strains derived from Asia, Europe, and North America, and among tick species that carry the infection, but little variability has been described within foci or tick species. Read More

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Simultaneous Detection and Differentiation of Clinically Relevant Relapsing Fever with Semimultiplex Real-Time PCR.

J Clin Microbiol 2021 Jun 18;59(7):e0298120. Epub 2021 Jun 18.

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.

Bacterial vector-borne diseases, including species, present a significant diagnostic, clinical, and public health challenge due to their overlapping symptoms and the breadth of causative agents and arthropod vectors. The relapsing fever (RF) borreliae encompass both established and emerging pathogens and are transmitted to humans by soft ticks, hard ticks, or lice. We developed a real-time semimultiplex PCR assay that detects multiple RF borreliae causing human illness and classifies them into one of three groups. Read More

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Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea.

Ticks Tick Borne Dis 2021 07 15;12(4):101711. Epub 2021 Mar 15.

Daejeon Metropolitan City Institute of Health and Environment, 407 Daehak-ro, Yuseong-gu, Daejeon, 34142, Republic of Korea.

Ticks (Ixodidae, also known as hard ticks) as principal vectors of zoonotic diseases such as severe fever with thrombocytopenia syndrome (SFTS), Lyme borreliosis, relapsing fever, anaplasmosis, ehrlichiosis, babesiosis, coxiellosis (Q fever), and tularemia pose a major public health threat. This study was conducted to identify the distribution profile of ticks and tick-borne pathogens in Daejeon and the adjacent areas in South Korea, where no such epidemiological study has been conducted. From April to October 2019, 16,765 ticks were collected from three genera and four species: Haemaphysalis longicornis (n = 14,949; 89. Read More

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RNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle.

Parasit Vectors 2021 Mar 20;14(1):170. Epub 2021 Mar 20.

Parasitología Animal, Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA, CSIC), Cordel de Merinas, 40-52, 37008, Salamanca, Spain.

Background: The argasid tick Ornithodoros erraticus is the main vector of tick-borne human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin. Tick salivary proteins secreted to the host at the feeding interface play critical roles for tick feeding and may contribute to host infection by tick-borne pathogens; accordingly, these proteins represent interesting antigen targets for the development of vaccines aimed at the control and prevention of tick infestations and tick-borne diseases.

Methods: To identify these proteins, the transcriptome of the salivary glands of O. Read More

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Transmission of the Human Relapsing Fever Spirochete Borrelia persica by the Argasid Tick Ornithodoros tholozani Involves Blood Meals from Wildlife Animal Reservoirs and Mainly Transstadial Transfer.

Appl Environ Microbiol 2021 05 11;87(11). Epub 2021 May 11.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel

, transmitted by the argasid tick , causes human tick-borne relapsing fever in the Middle East and Central Asia. Infection is acquired often when visiting tick-infested caves and reported to be transmitted mainly transovarially between ticks, occasionally infecting humans. To study the epidemiology of this infection, ticks were trapped in 24 caves in 12 geographic zones covering all of Israel and identified morphologically. Read More

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First detection of Borrelia miyamotoi infections in ticks and humans from the northeast of Inner Mongolia, China.

Acta Trop 2021 May 11;217:105857. Epub 2021 Feb 11.

College of Veterinary Medicine, Northeast Agricultural University, Changjiang Road No.600, Harbin 150030, Heilongjiang Province, China. Electronic address:

Borrelia miyamotoi is a relapsing fever spirochete that can cause chills, fatigue, headache, myalgia, arthralgia, and even meningitis, damaging human health. B. miyamotoi has a wide distribution since its discovery in Ixodes persulcatus in 1994. Read More

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Sialotranscriptomics of the argasid tick Ornithodoros moubata along the trophogonic cycle.

PLoS Negl Trop Dis 2021 02 5;15(2):e0009105. Epub 2021 Feb 5.

Parasitology Laboratory, Institute of Natural Resources and Agrobiology (IRNASA, CSIC), Cordel de Merinas, Salamanca, Spain.

The argasid tick Ornithodoros moubata is the main vector of human relapsing fever (HRF) and African swine fever (ASF) in Africa. Salivary proteins are part of the host-tick interface and play vital roles in the tick feeding process and the host infection by tick-borne pathogens; they represent interesting targets for immune interventions aimed at tick control. The present work describes the transcriptome profile of salivary glands of O. Read More

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February 2021

Quantitative real-time PCR in Borrelia persica tick-borne relapsing fever demonstrates correlation with the Jarisch-Herxheimer reaction.

Eur J Clin Microbiol Infect Dis 2021 May 4;40(5):1113-1116. Epub 2021 Jan 4.

Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

The purpose of this study is to explore whether a correlation exists between the bacterial load of Borrelia persica in tick-borne relapsing fever (TBRF), established by quantitative real-time PCR, and the development of Jarisch-Herxheimer reaction (JHR) after the initiation of antibiotic treatment. Forty-two blood samples were included in our study. The mean bacterial load, as established by real-time PCR, in patients who developed JHR was significantly greater than in those patients who did not develop JHR (443,293 copies vs. Read More

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Borrelia in neotropical bats: Detection of two new phylogenetic lineages.

Ticks Tick Borne Dis 2021 03 28;12(2):101642. Epub 2020 Dec 28.

Centro de Medicina Tropical, Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address:

The genus Borrelia encompasses 50 spirochetal species, several of which are pathogenic and have been detected in a wide range of mammals, especially rodents and cervids. Although the order Chiroptera is the second most diverse mammalian order, and borreliosis represents a human and veterinary health problem in endemic countries, few studies have previously reported infections of Borrelia in these flying mammals. For this reason, the aim of the present study was to detect the presence of, and to analyze the diversity of Borrelia species in several bat species from Mexico. Read More

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Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors.

PLoS One 2020 28;15(12):e0243950. Epub 2020 Dec 28.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, United States of America.

The western blacklegged tick, Ixodes pacificus, an important vector in the western United States of two zoonotic spirochetes: Borrelia burgdorferi (also called Borreliella burgdorferi), causing Lyme disease, and Borrelia miyamotoi, causing a relapsing fever-type illness. Human cases of Lyme disease are well-documented in California, with increased risk in the north coastal areas and western slopes of the Sierra Nevada range. Despite the established presence of B. Read More

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February 2021

Aggregation of data from 4 clinical studies demonstrating efficacy of single-dose doxycycline postexposure for prevention of the spirochetal infections: Lyme disease, syphilis, and tick-borne relapsing fever.

Diagn Microbiol Infect Dis 2021 Apr 13;99(4):115293. Epub 2020 Dec 13.

Baystate Medical Center, Springfield, MA, USA.

Single-dose doxycycline, given within 72 hours of exposure, has been evaluated in 4 clinical studies for postexposure prophylaxis of 3 spirochetal infections: Lyme disease, syphilis, and tick-borne relapsing fever. In this study, data from the 4 studies were aggregated using a meta-analytic random-effects approach, with the DerSimonian-Laird method for variance estimation, analyzing a total of 2468 subjects. The findings of this analysis demonstrated an overall efficacy rate for prevention of the 3 spirochetal infections of 78% (95% confidence interval: 50%-91%). Read More

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Relapsing Fever Group Borreliae in Human-Biting Soft Ticks, Brazil.

Emerg Infect Dis 2021 01;27(1):322-324

We conducted a molecular survey for Borrelia spp. in Ornithodoros ticks previously reported as biting humans. We collected specimens in natural ecosystems and inside human dwellings in 6 states in Brazil. Read More

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January 2021

Pathogen Coinfections Harbored by Adult from White-Tailed Deer Compared with Questing Adults Across Sites in Maryland, USA.

Vector Borne Zoonotic Dis 2021 Feb 14;21(2):86-91. Epub 2020 Dec 14.

Invasive Insect Biocontrol & Behavior Laboratory, USDA-ARS, Beltsville, Maryland, USA.

The blacklegged tick, , can acquire and transmit tick-borne pathogens (TBPs) responsible for diseases such as human granulocytic anaplasmosis ( [ANPH]), babesiosis ( [BABE]), Lyme borreliosis ( lato [BBSL]), and the relatively novel relapsing fever-like illness, (BMIY) disease in the northeastern United States. Coinfections with these pathogens are becoming increasingly more common in and their hosts, likely attributed to their shared enzootic cycles. Urban habitats are favorable to host species such as white-tailed deer () and these ungulates are known to be important to for reproduction and dispersal in North America. Read More

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February 2021

A case of tick-borne relapsing fever in pregnancy.

Can Commun Dis Rep 2020 Oct 1;46(10):362-364. Epub 2020 Oct 1.

Division of Infectious Diseases, Department of Medicine, University of Calgary, Calgary, AB.

Tick-borne relapsing fever (TBRF) is an infection caused by spirochetes. In North America, is the most common cause for TBRF. This vector-borne disease is transmitted by , a soft-bodied tick found in high altitudes in northwestern United States and southwestern Canada. Read More

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October 2020

Tick-borne diseases and co-infection: Current considerations.

Ticks Tick Borne Dis 2021 01 9;12(1):101607. Epub 2020 Nov 9.

European Centre for Disease Prevention and Control, Solna, Sweden.

Over recent years, a multitude of pathogens have been reported to be tick-borne. Given this, it is unsurprising that these might co-exist within the same tick, however our understanding of the interactions of these agents both within the tick and vertebrate host remains poorly defined. Despite the rich diversity of ticks, relatively few regularly feed on humans, 12 belonging to argasid and 20 ixodid species, and literature on co-infection is only available for a few of these species. Read More

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January 2021

Pathogenic New World Relapsing Fever Borrelia in a Myotis Bat, Eastern China, 2015.

Emerg Infect Dis 2020 12;26(12):3083-3085

We identified Candidatus Borrelia fainii, a human pathogenic bacterium causing New World relapsing fever in a Myotis bat in eastern China. This finding expands knowledge about the geographic distribution of Borrelia spp. and the potential for infection with New World relapsing fever in China. Read More

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December 2020

Serology in a Clinical Population With Persistent Symptoms and Suspected Tick-Borne Illness.

Front Med (Lausanne) 2020 27;7:567350. Epub 2020 Oct 27.

Lyme & Tick-Borne Diseases Research Center, Columbia University Irving Medical Center, New York, NY, United States.

Eighty-two patients seeking consultation for long-term sequalae after suspected tick-borne illness were consecutively tested for antibodies using a recombinant glycerophosphodiester phosphodiesterase (GlpQ) enzyme immunoassay. Twenty-one of the 82 patients (26%) tested positive on the GlpQ IgG ELISA. Nearly all of the patients (98%) had no prior testing, indicating that clinicians rarely test for this emerging tick-borne pathogen. Read More

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October 2020

The habitat suitability model for the potential distribution of Ornithodoros tholozani (Laboulbène et Mégnin, 1882) and Ornithodoros lahorensis (Neumann, 1908) (Acari: Argasidae): the main vectors of tick-borne relapsing fever in Iran.

Ann Parasitol 2020 ;66(3):357-363

Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Ghods 31, Tehran 1417613151, Iran.

Endemic relapsing fever (RF) is one of the most important arthropod-borne diseases caused by various types of Borrelia and transmitted by soft tick species. The investigation of the distribution of vectors in a region can help control and prevent the disease. This study aimed to investigate the distribution of Ornithodoros tholozani and Ornithodoros lahorensis in Iran and to identify the most influential climatic variables affecting their distribution. Read More

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November 2020

Borrelia miyamotoi strain LB-2001 retains plasmids and infectious phenotype throughout continuous culture passages as evaluated by multiplex PCR.

Ticks Tick Borne Dis 2021 01 6;12(1):101587. Epub 2020 Oct 6.

Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.

Borrelia miyamotoi is a tick-borne spirochete of the relapsing fever borrelia group and an emerging pathogen of public health significance. The genomes of relapsing fever borreliae and Lyme disease borreliae consist of multiple linear and circular plasmids in addition to the chromosome. Previous work with B. Read More

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January 2021

Case 32-2020: A 63-Year-Old Man with Confusion, Fatigue, and Garbled Speech.

N Engl J Med 2020 10;383(16):1578-1586

From the Departments of Neurology (S.S.M.), Medicine (K.L.A.), Radiology (P.W.S.), and Pathology (J.A.B.), Massachusetts General Hospital, and the Departments of Neurology (S.S.M.), Medicine (K.L.A.), Radiology (P.W.S.), and Pathology (J.A.B.), Harvard Medical School - both in Boston.

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October 2020

The impact of in vitro cultivation on the natural life cycle of the tick-borne relapsing fever spirochete Borrelia turicatae.

PLoS One 2020 12;15(10):e0239089. Epub 2020 Oct 12.

Department of Pediatrics, National School of Tropical Medicine, Baylor College Medicine, Houston, Texas, United States of America.

Tick-borne relapsing fever is an infectious disease caused by Borrelia species and are primarily transmitted by Ornithodoros ticks. Prior work indicated that in vitro cultivated spirochetes remain infectious to mice by needle inoculation; however, the impact of laboratory propagation on the pathogens natural life cycle has not been determined. Our current study assessed the effect of serial cultivation on the natural tick-mammalian transmission cycle. Read More

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November 2020

Molecular detection of pathogens from ectoparasites recovered from peri-domestic animals, and the first description of a Candidatus Midichloria sp. from Haemaphysalis wellingtoni from rural communities in Malaysia.

Parasitol Int 2021 Feb 8;80:102202. Epub 2020 Oct 8.

Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Rural communities in Malaysia have been shown to be exposed to Coxiella, Borrelia and rickettsial infections in previous seroprevalence studies. Further research is necessary to identify the actual causative agents and the potential vectors of these infections. The arthropods parasitizing peri-domestic animals in these communities may serve as the vector in transmitting arthropod-borne and zoonotic agents to the humans. Read More

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February 2021

Infection of hard ticks in the Caspian Sea littoral of Iran with Lyme borreliosis and relapsing fever borreliae.

Ticks Tick Borne Dis 2020 11 1;11(6):101500. Epub 2020 Jul 1.

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran; National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.

The Caspian Sea littoral of Iran is home to various hard tick species, including Ixodes ricinus, the notorious vector of Lyme borreliosis (LB) in Eurasia. Here, in this area, we examined I. ricinus and other hard ticks, along with common rodents and small mammals for LB and relapsing fever (RF) borreliae infection. Read More

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November 2020

Identification and functional analysis of ferritin 2 from the Taiga tick Ixodes persulcatus Schulze.

Ticks Tick Borne Dis 2020 11 29;11(6):101547. Epub 2020 Aug 29.

Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, 060-0818, Japan; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, 060-0818, Japan.

Ferritin 2 (FER2) is an iron storage protein, which has been shown to be critical for iron homeostasis during blood feeding and reproduction in ticks and is therefore suitable as a component for anti-tick vaccines. In this study, we identified the FER2 of Ixodes persulcatus, a major vector for zoonotic diseases such as Lyme borreliosis and tick-borne relapsing fever in Japan, and investigated its functions. Ixodes persulcatus-derived ferritin 2 (Ip-FER2) showed concentration-dependent iron-binding ability and high amino acid conservation, consistent with FER2s of other tick species. Read More

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November 2020

Gastrointestinal and hepatic symptoms of tickborne diseases.

Vnitr Lek 2020 ;66(4):232-235

While investigating patients with gastrointestinal (GI) and/or hepatic symptoms, tickborne diseases are only rarely considered to be the cause. However, the Czech Republic is an endemic region for several of tickborne diseases and, therefore, they should be a part of differential diagnosis of GI symptoms of unknown origin. This article describes GI and hepatic symptoms of several tickborne diseases - Lyme disease, ehrlichiosis, Rocky mountain spotted fever, tularemia, Colorado tick fever, tickborne relapsing fever, Q fever and babesiosis. Read More

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November 2020