12,324 results match your criteria Tick-Borne Diseases Lyme

[Role of systemic infections in canine kidney diseases].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2022 Apr 6;50(2):124-136. Epub 2022 May 6.

Medizinische Kleintierklinik, Zentrum für klinische Tiermedizin, Ludwig-Maximilians-Universität München.

Kidney diseases represent a common problem as well as a frequent cause of death in dogs. Infectious agents may be responsible for glomerulopathies and acute kidney injuries. Many infections commonly associated with the development of immune complex glomerulonephritis in central and southern Europe are important as travel-associated diseases in Germany. Read More

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Cerebrospinal fluid markers of inflammation and brain injury in Lyme neuroborreliosis - a prospective follow-up study.

Clin Chem Lab Med 2022 May 2. Epub 2022 May 2.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden.

Objectives: The purpose of this study was to evaluate levels and kinetics of cerebrospinal fluid (CSF) markers of inflammation and brain injury in patients with Lyme neuroborreliosis (LNB).

Methods: Adult patients with clinically suspected LNB were enrolled, in a prospective clinical study in the South East of Sweden. Patients were classified according to the European Federation of Neurological Societies' guidelines. Read More

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Deletion of a Genetic Region of lp17 Affects Plasmid Copy Number in .

Front Cell Infect Microbiol 2022 12;12:884171. Epub 2022 Apr 12.

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, United States.

, the Lyme disease pathogen, is maintained in its enzootic life cycle through complex gene regulatory pathways encoded on its uniquely fragmented genome. This genome consists of over 20 plasmids, and the regulatory mechanisms of plasmid maintenance and replication are largely unknown. The gene, encoded on lp17 and a member of the paralogous family 32 proteins, was originally proposed to be a putative orthologue involved with plasmid partitioning; however, this function has not been confirmed to date. Read More

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A Computer Vision Approach to Identifying Ticks Related to Lyme Disease.

IEEE J Transl Eng Health Med 2022 30;10:4900308. Epub 2021 Dec 30.

Vector Institute for Artificial Intelligence Toronto ON M5G 1M1 Canada.

Lyme disease (caused by ) is an infectious disease transmitted to humans by a bite from infected blacklegged ticks () in eastern North America. Lyme disease can be prevented if antibiotic prophylaxis is given to a patient within 72 hours of a blacklegged tick bite. Therefore, recognizing a blacklegged tick could facilitate the management of Lyme disease. Read More

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Behavioral risk factors associated with reported tick exposure in a Lyme disease high incidence region in Canada.

BMC Public Health 2022 Apr 22;22(1):807. Epub 2022 Apr 22.

Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique (GREZOSP), Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.

Background: Tick-borne diseases, and especially Lyme Disease (LD), are on the rise in Canada and have been met with increasing public health concern. To face these emerging threats, education on the prevention of tick bites remains the mainstay of public health intervention. The objective of this study was to assess the adoption of preventive behaviors toward tick bites and LD and to investigate the association between behavioral risk factors and reported tick exposure in a Canadian, LD high incidence region (Estrie region, Quebec, Canada). Read More

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Plasma Proteomic Profile of Patients with Tick-Borne Encephalitis and Co-Infections.

Int J Mol Sci 2022 Apr 15;23(8). Epub 2022 Apr 15.

Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.

Despite the increasing number of patients suffering from tick-borne encephalitis (TBE), Lyme disease, and their co-infection, the mechanisms of the development of these diseases and their effects on the human body are still unknown. Therefore, the aim of this study was to evaluate the changes in the proteomic profile of human plasma induced by the development of TBE and to compare it with changes in TBE patients co-infected with other tick-borne pathogens. The results obtained by proteomic analysis using a nanoLC-Q Exactive HF mass spectrometer showed that the most highly elevated groups of proteins in the plasma of TBE patients with co-infection were involved in the pro-inflammatory response and protein degradation, while the antioxidant proteins and factors responsible for protein biosynthesis were mainly downregulated. Read More

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Model-based extrapolation of ecological systems under future climate scenarios: The example of Ixodes ricinus ticks.

PLoS One 2022 22;17(4):e0267196. Epub 2022 Apr 22.

Department of Ecological Modelling, Helmholtz-Centre for Environmental Research GmbH-UFZ, Leipzig, Germany.

Models can be applied to extrapolate consequences of climate change for complex ecological systems in the future. The acknowledged systems' behaviour at present is projected into the future considering climate projection data. Such an approach can be used to addresses the future activity and density of the castor bean tick Ixodes ricinus, the most widespread tick species in Europe. Read More

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Effects of Tick-Control Interventions on Tick Abundance, Human Encounters with Ticks, and Incidence of Tickborne Diseases in Residential Neighborhoods, New York, USA.

Emerg Infect Dis 2022 05;28(5):957-966

Tickborne diseases (TBDs) such as Lyme disease result in ≈500,000 diagnoses annually in the United States. Various methods can reduce the abundance of ticks at small spatial scales, but whether these methods lower incidence of TBDs is poorly understood. We conducted a randomized, replicated, fully crossed, placebo-controlled, masked experiment to test whether 2 environmentally safe interventions, the Tick Control System (TCS) and Met52 fungal spray, used separately or together, affected risk for and incidence of TBDs in humans and pets in 24 residential neighborhoods. Read More

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Radiculoneuritis due to Lyme disease in a North American child.

Am J Emerg Med 2022 Apr 7. Epub 2022 Apr 7.

Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, United States of America; Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA, United States of America.

Lyme disease is the most frequently reported vector-borne illness in the United States. It is caused by infection with Borrelia burgdorferi via the bite of an infected blacklegged tick (Ixodes spp.) Lyme disease has three stages: early localized, early disseminated, and late. Read More

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Exploring the Effects of Prescribed Fire on Tick Spread and Propagation in a Spatial Setting.

Comput Math Methods Med 2022 5;2022:5031806. Epub 2022 Apr 5.

Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence KS, USA.

Lyme disease is one of the most prominent tick-borne diseases in the United States, and prevalence of the disease has been steadily increasing over the past several decades due to a number of factors, including climate change. Methods for control of the disease have been considered, one of which is prescribed burning. In this paper, the effects of prescribed burns on the abundance of ticks present in a spatial domain are assessed. Read More

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Spatiotemporal trends and socioecological factors associated with Lyme disease in eastern Ontario, Canada from 2010-2017.

BMC Public Health 2022 Apr 13;22(1):736. Epub 2022 Apr 13.

School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.

Currently, there is limited knowledge about socioeconomic, neighbourhood, and local ecological factors that contribute to the growing Lyme disease incidence in the province of Ontario, Canada. In this study, we sought to identify these factors that play an important role at the local scale, where people are encountering ticks in their communities. We used reported human Lyme disease case data and tick surveillance data submitted by the public from 2010-2017 to analyze trends in tick exposure, spatiotemporal clusters of infection using the spatial scan statistic and Local Moran's I statistic, and socioecological risk factors for Lyme disease using a multivariable negative binomial regression model. Read More

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Measurement of High Sensitivity Troponin T in Patients with Early Stage Lyme Disease: Preliminary Evidence for Possible Subclinical Cardiac Involvement.

Ann Clin Lab Sci 2022 Mar;52(2):179-184

Department of Pathology, Division of Clinical Laboratories and Molecular Medicine, Massachusetts General Hospital, Boston, MA, USA

Objective: In patients with early Lyme disease (ELD), cardiac involvement is known to occur in approximately 1% of patients. We measured high-sensitivity troponin T (hsTnT) in patients with early Lyme disease to evaluate the possibility of subclinical cardiac involvement.

Methods: We measured hsTnT in 41 patients with well characterized ELD. Read More

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Persistent Symptoms, Lyme Disease, and Prior Trauma.

J Nerv Ment Dis 2022 May;210(5):359-364

Abstract: One prior study suggests that traumatic events before Lyme disease play an important role in symptom severity. We examined this hypothesis among 60 individuals with persistent symptoms after Lyme disease using validated measures of trauma history, mental and physical symptoms, and functional status. Analysis of variance with Tukey-Kramer multiple comparisons test revealed that a greater number of traumatic events were significantly associated with greater symptom severity on the scales of mood (stress, depression, and anxiety), cognition, multisystem symptom burden, and functional status (mental and physical), but not on measures of pain and fatigue. Read More

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Mapping the risk distribution of sensu lato in China from 1986 to 2020: a geospatial modelling analysis.

Emerg Microbes Infect 2022 Dec;11(1):1215-1226

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.

Lyme borreliosis, recognized as one of the most important tick-borne diseases worldwide, has been increasing in incidence and spatial extent. Currently, there are few geographic studies about the distribution of Lyme borreliosis risk across China. Here we established a nationwide database that involved sensu lato () detected in humans, vectors, and animals in China. Read More

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December 2022

Invasive raccoon (Procyon lotor) and raccoon dog (Nyctereutes procyonoides) as potential reservoirs of tick-borne pathogens: data review from native and introduced areas.

Parasit Vectors 2022 Apr 11;15(1):126. Epub 2022 Apr 11.

Department of Parasitology, Faculty of Biological Sciences, University of Wrocław, Wrocław, Poland.

In recent decades, populations of the raccoon (Procyon lotor) and the raccoon dog (Nyctereutes procyonides) have increased and adapted to peri-urban and urban environments in many parts of the world. Their ability to rapidly colonize new territories, high plasticity and behavioral adaptation has enabled these two species to be considered two of the most successful invasive alien species. One of the major threats arising from continually growing and expanding populations is their relevant role in maintaining and transmitting various vector-borne pathogens among wildlife, domestic animals and humans. Read More

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A 60-Year-Old Swiss Woman Presenting with Migratory Radicular Pain Diagnosed with Lyme Disease by Western Blot.

Am J Case Rep 2022 Apr 10;23:e935717. Epub 2022 Apr 10.

Private Clinical Practice, Marly, Switzerland.

BACKGROUND Many diagnostic guidelines have been established to support the diagnosis of Lyme disease, but a recent meta-analysis did not find that 2-tier tests were better than individual tests. Here, we present the case of a patient who was diagnosed by immunoblot only, a second-line test that is usually not performed if the first-line test is negative. CASE REPORT A 60-year-old Swiss woman, without relevant comorbidities, presented to our clinic with 1-week symptoms of migratory radiculitis in the L1, L2, and L5-S1 right dermatomes. Read More

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Sensitisation and allergic reactions to alpha-1,3-galactose in Podlasie, Poland, an area endemic for tick-borne infections.

Infect Dis (Lond) 2022 Apr 5:1-8. Epub 2022 Apr 5.

Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Białystok, Poland.

Purpose: Ticks transmit several pathogens and seem implicated in the production of specific IgE antibodies to alpha-1,3-galactose (α-gal sIgE). They cause delayed and immediate allergy to mammalian meat and medication including antivenoms, vaccines and monoclonal antibodies.

Methods: We assessed the prevalence of α-gal sIgE in forest workers and healthy controls in the Podlasie voivodeship, north-eastern Poland; the relationship between α-gal sIgE and allergy to α-gal-containing products; the correlation between α-gal sIgE and anti- and anti-tick-borne encephalitis virus (TBEV) antibodies; the relationship between α-gal sIgE and markers of infection with lesser-known pathogens transmitted by ticks such as . Read More

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Personal protection measures to prevent tick bites in the United States: Knowledge gaps, challenges, and opportunities.

Lars Eisen

Ticks Tick Borne Dis 2022 Mar 26;13(4):101944. Epub 2022 Mar 26.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA. Electronic address:

Personal protection measures to prevent human tick encounters from resulting in bites are widely recommended as the first line of defense against health impacts associated with ticks. This includes using repellents, wearing untreated or permethrin-treated protective clothing, and conducting tick checks after coming inside, aided by removing outdoor clothing articles and running them in a dryer on high heat (to kill undetected ticks) and taking a shower/bath (to aid in detecting ticks on the skin). These measures have the benefit of incurring no or low cost, but they need to be used consistently to be most effective. Read More

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Could the Optiplex assay replace the traditional, two-step method of diagnosing Lyme disease?

Ann Agric Environ Med 2022 Mar 16;29(1):63-71. Epub 2022 Mar 16.

Department of Laboratory Medicine, Pomeranian Medical University, Szczecin, Poland.

Introduction And Objective: Serological assays for Lyme disease (LD) routinely performed in laboratories often give inconclusive results, thereby making correct diagnosis difficult and delaying treatment. The aim of the study was to assess the usefulness of a commercial Optiplex (OB) assay in the serological diagnostics of LD. Based on the results obtained in a previous study on the seroreactivity of the sera of patients with LD to spp. Read More

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An unexpected case of Borrelia garinii liver infection.

Ann Clin Microbiol Antimicrob 2022 Mar 27;21(1):15. Epub 2022 Mar 27.

Centre Hospitalier Universitaire de Bordeaux, Laboratoire de Bactériologie, 33000, Bordeaux, France.

Background: Lyme borreliosis is the most prevalent arthropod-borne infection in the Northern Hemisphere. In Europe, Borrelia afzelii is predominantly involved in cutaneous manifestations, Borrelia garinii and Borrelia bavariensis in neurological manifestations, and Borrelia burgdorferi sensu stricto in articular ones. Liver impairement is not classical in Lyme borreliosis. Read More

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Multidisciplinary Management of Suspected Lyme Borreliosis: Clinical Features of 569 Patients, and Factors Associated with Recovery at 3 and 12 Months, a Prospective Cohort Study.

Microorganisms 2022 Mar 12;10(3). Epub 2022 Mar 12.

Epidemiology of Emerging Diseases Unit, Institut Pasteur, 75015 Paris, France.

. Because patients with a suspicion of Lyme borreliosis (LB) may have experienced difficult care paths, the Tick-Borne Diseases Reference Center (TBD-RC) was started in 2017. The aim of our study was to compare the clinical features of patients according to their final diagnoses, and to determine the factors associated with recovery in the context of multidisciplinary management for suspected LB. Read More

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Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis.

Pathogens 2022 Mar 17;11(3). Epub 2022 Mar 17.

Anses, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France.

The tick-borne encephalitis virus (TBEV) causes a life-threatening disease named Tick-borne encephalitis (TBE). The clinical symptoms associated with TBE range from non-specific to severe inflammation of the central nervous system and are very similar to the clinical presentation of other viral meningitis/encephalitis. In consequence, TBE is often misclassified by clinical physicians, mainly in the non-identified high-risk areas where none or only a few TBE cases have been reported. Read More

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Human Co-Infections between s.l. and Other -Borne Microorganisms: A Systematic Review.

Pathogens 2022 Feb 23;11(3). Epub 2022 Feb 23.

Institut de Bactériologie, Fédération de Médecine Translationnelle de Strasbourg, University of Strasbourg, UR7290, ITI InnoVec, 3 Rue Koeberlé, F-67000 Strasbourg, France.

When it comes to tick-borne diseases, co-infections are often mentioned. This concept includes several entities. On the one hand, tick vectors or vertebrate reservoir host can harbor several microorganisms that can be pathogenic for humans. Read More

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February 2022

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15.

Int J Mol Sci 2022 Mar 15;23(6). Epub 2022 Mar 15.

Centro de Investigaciones Biológicas, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.

Salp15 is one of the proteins in the saliva of the tick . Together with other biomolecules injected into the mammalian host at the biting site, it helps the tick to sustain its blood meal for days. Salp15 interferes with the cellular immune response of the mammalian host by inhibiting the activation of CD4 T-lymphocytes. Read More

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The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNβ-mediated Lyme arthritis.

PLoS Pathog 2022 03 24;18(3):e1010365. Epub 2022 Mar 24.

Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America.

Type I interferon (IFN) has been identified in patients with Lyme disease, and its abundant expression in joint tissues of C3H mice precedes development of Lyme arthritis. Forward genetics using C3H mice with severe Lyme arthritis and C57BL/6 (B6) mice with mild Lyme arthritis identified the Borrelia burgdorferi arthritis-associated locus 1 (Bbaa1) on chromosome 4 (Chr4) as a regulator of B. burgdorferi-induced IFNβ expression and Lyme arthritis severity. Read More

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Characteristics of Lyme optic neuritis: a case report of Lyme associated bilateral optic neuritis and systematic review of the literature.

BMC Neurol 2022 Mar 23;22(1):113. Epub 2022 Mar 23.

Department of Neurology, Neuroscience Institute, Geisinger Health System, Danville, PA, USA.

Optic Neuritis is rare in Lyme borreliosis. The current knowledge of optic nerve involvement in Lyme borreliosis relies solely on case reports. The aim of this systematic review was to characterize and investigate the associated factors of optic neuritis in Lyme borreliosis. Read More

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Incidence of Lyme disease in the United Kingdom and association with fatigue: A population-based, historical cohort study.

PLoS One 2022 23;17(3):e0265765. Epub 2022 Mar 23.

Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: Estimations of Lyme disease incidence rates in the United Kingdom vary. There is evidence that this disease is associated with fatigue in its early stage but reports are contradictory as far as long-term fatigue is concerned.

Methods And Findings: A population-based historical cohort study was conducted on patients treated in general practices contributing to IQVIA Medical Research Data: 2,130 patients with a first diagnosis of Lyme disease between 2000 and 2018 and 8,510 randomly-sampled patients matched by age, sex, and general practice, followed-up for a median time of 3 years and 8 months. Read More

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Unique Clinical, Immune, and Genetic Signature in Patients with Borrelial Meningoradiculoneuritis.

Emerg Infect Dis 2022 04;28(4)

Lyme neuroborreliosis (LNB) in Europe may manifest with painful meningoradiculoneuritis (also known as Bannwarth syndrome) or lymphocytic meningitis with or without cranial neuritis (peripheral facial palsy). We assessed host immune responses and the prevalence of TLR1 (toll-like receptor 1)-1805GG polymorphism to gain insights into the pathophysiology of these conditions. Regardless of LNB manifestation, most mediators associated with innate and adaptive immune responses were concentrated in cerebrospinal fluid; serum levels were unremarkable. Read More

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[Diplopia and neck pain may be a sign of Lyme neuroborreliosis].

Ugeskr Laeger 2022 03;184(11)

Afdeling for Hjerne- og Nervesygdomme, Rigshospitalet.

We report the case of a 76-year-old male previously known with ischaemic heart disease, diabetes mellitus, hypertension and hypercholesterolaemia, who presented with a 14-day history of radicular neck pain, binocular diplopia and a left partial oculomotor palsy. Cerebrospinal fluid analysis showed lymphocytic pleocytosis and an intrathecal synthesis of IgG and IgM antibodies against Borrelia burgdorferi was confirmed. This case report highlights the importance of remembering Lyme neuroborreliosis in the differential diagnosis of diplopia and oculomotor palsy. Read More

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[Lyme neuroborreliosis in adults].

Ugeskr Laeger 2022 03;184(10)

Medicinsk Afdeling, Sjællands Universitetshospital Roskilde.

Lyme neuroborreliosis (LNB) caused by the spirochete bacteria Borrelia burgdorferi sensu lato complex is the most common bacterial neuroinfection in Denmark (180 cases per year). One of the main challenges to LNB is the diagnosis due to its variant manifestations often involving the skin, musculosceletal or nervous system affecting patient morbidity. Recent data shows a diagnostic delay of 21 days in laboratory-confirmed patients in Denmark. Read More

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