11,400 results match your criteria Tick-Borne Diseases Lyme


Emerging tick-borne pathogens of public health importance: a mini-review.

J Med Microbiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Entomology, Rutgers University, New Brunswick, NJ, USA.

Ticks are the most important vectors of human pathogens, leading to increased public health burdens worldwide. Tick-borne pathogens include viruses (e.g. Read More

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http://dx.doi.org/10.1099/jmm.0.001206DOI Listing

Presence of Borrelia miyamotoi infection in a highly endemic area of Lyme disease.

Ann Clin Microbiol Antimicrob 2020 May 30;19(1):22. Epub 2020 May 30.

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

A series of cases in the Northeast of the US during 2013-2015 described a new Borrelia species, Borrelia miyamotoi, which is transmitted by the same tick species that transmits Lyme disease and causes a relapsing fever-like illness. The geographic expansion of B. miyamotoi in the US also extends to other Lyme endemic areas such as the Midwestern US. Read More

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http://dx.doi.org/10.1186/s12941-020-00364-0DOI Listing

Guillain-Barre Syndrome, Neuroborreliosis, or Both.

Cureus 2020 Apr 25;12(4):e7823. Epub 2020 Apr 25.

Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA.

Guillain-Barre syndrome (GBS) is an acute paralytic neuropathy. Limited reports of GBS caused by tick-borne pathogens exist. Lyme disease is a tick-borne infectious disease that is commonly caused by Borrelia burgdorferi. Read More

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http://dx.doi.org/10.7759/cureus.7823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249767PMC

Epidemiology and cost of Lyme disease-related hospitalizations among patients with employer-sponsored health insurance-United States, 2005-2014.

Zoonoses Public Health 2020 Jun;67(4):407-415

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.

An estimated 300,000 cases of Lyme disease occur in the United States annually. Disseminated Lyme disease may result in carditis, arthritis, facial palsy or meningitis, sometimes requiring hospitalization. We describe the epidemiology and cost of Lyme disease-related hospitalizations. Read More

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http://dx.doi.org/10.1111/zph.12699DOI Listing

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy: (En français : Prise en charge des morsures de tiques et de la maladie de Lyme pendant la grossesse).

J Obstet Gynaecol Can 2020 May;42(5):644-653

Halifax, NS.

Objective: Lyme disease is an emerging infection in Canada caused by the bacterium belonging to the Borrelia burgdorferi sensu lato species complex, which is transmitted via the bite of an infected blacklegged tick. Populations of blacklegged ticks continue to expand and are now established in different regions in Canada. It usually takes more than 24 hours of tick attachment to transfer B. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.01.001DOI Listing

Predominant risk factors for tick-borne co-infections in hunting dogs from the USA.

Parasit Vectors 2020 May 13;13(1):247. Epub 2020 May 13.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, 52242, USA.

Background: Both incidence and geographical range of tick-borne disease has increased across the USA. Similar to people, dogs are hosts for Anaplasma spp., Babesia spp. Read More

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http://dx.doi.org/10.1186/s13071-020-04118-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218638PMC
May 2020
3.430 Impact Factor

Subjective health complaints and exposure to tick-borne infections in southern Norway.

Acta Neurol Scand 2020 May 11. Epub 2020 May 11.

Department of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway.

Objectives: Whether tick-borne infections can cause chronic subjective health complaints is heavily debated. If such a causal connection exists, one would expect to find more health complaints among individuals exposed to tick-borne infections than among non-exposed. In this study, we aimed to assess if exposure to tick-borne infections earlier in life, evaluated by examination of serum for IgG antibodies to tick-borne microbes, was associated with self-reported somatic symptom load. Read More

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http://dx.doi.org/10.1111/ane.13263DOI Listing

Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995-2014.

Sci Rep 2020 May 8;10(1):7796. Epub 2020 May 8.

Clinical Institute, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

In Europe, Lyme neuroborreliosis (LNB) is the most severe manifestation of Lyme borreliosis and has recently been added to the communicable disease surveillance list for EU/EEA by the European Commission. In Northern Europe, LNB is primarily caused by the spirochete Borrelia garinii and transmitted by the tick Ixodes ricinus. This Danish observational epidemiologic case-control study includes every identified LNB patient (n = 401) on Funen, Denmark, from 1995-2014. Read More

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http://dx.doi.org/10.1038/s41598-020-64638-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210281PMC

Design of a broadly reactive Lyme disease vaccine.

NPJ Vaccines 2020 1;5:33. Epub 2020 May 1.

1Sanofi, 640 Memorial Dr, Cambridge, MA 01239 USA.

A growing global health concern, Lyme disease has become the most common tick-borne disease in the United States and Europe. Caused by the bacterial spirochete sensu lato (sl), this disease can be debilitating if not treated promptly. Because diagnosis is challenging, prevention remains a priority; however, a previously licensed vaccine is no longer available to the public. Read More

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http://dx.doi.org/10.1038/s41541-020-0183-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195412PMC

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease.

Front Med (Lausanne) 2020 20;7:133. Epub 2020 Apr 20.

Centre Hospitalier de Lannemezan, Lannemezan, France.

Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease. Disulfiram has several distinct molecular targets. The most well-known is alcohol dehydrogenase, a key enzyme for detoxifying the organism after alcohol ingestion. Read More

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http://dx.doi.org/10.3389/fmed.2020.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184924PMC

A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Sensu Lato Species and Isolate Differentiation.

Front Microbiol 2020 21;11:690. Epub 2020 Apr 21.

Division of Infectious Diseases and Tropical Medicine, University Hospital LMU, Munich, Germany.

The genus comprises vector-borne bacterial pathogens that can severely affect human and animal health. Members of the sensu lato species complex can cause Lyme borreliosis, one of the most common vector-borne diseases in the Northern hemisphere. Besides, members of the relapsing fever group of spirochetes can cause tick-borne relapsing fever in humans and various febrile illnesses in animals in tropical, subtropical and temperate regions. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186393PMC

Barriers to Effective Tick Management and Tick-Bite Prevention in the United States (Acari: Ixodidae).

J Med Entomol 2020 May 6. Epub 2020 May 6.

Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, New Haven, CT.

Lyme and other tick-borne diseases are increasing in the United States. Development of tick control tools have focused primarily on the blacklegged tick, Ixodes scapularis Say. Application of acaricides or entomopathogenic fungal agents to kill host-seeking ticks or ticks on rodents can suppress I. Read More

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http://dx.doi.org/10.1093/jme/tjaa079DOI Listing

Tripartite Interactions among , and Deer: Differential Interference with Transmission Cycles of Tick-Borne Pathogens.

Pathogens 2020 Apr 30;9(5). Epub 2020 Apr 30.

Zoology Section, Department of Biology, Ege University Faculty of Science, Bornova Izmir 35040, Turkey.

For the development of sustainable control of tick-borne diseases, insight is needed in biological factors that affect tick populations. Here, the ecological interactions among , , and two vertebrate species groups were investigated in relation to their effects on tick-borne disease risk. In 1129 questing ticks, DNA was detected more often in nymphs (4. Read More

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http://dx.doi.org/10.3390/pathogens9050339DOI Listing

Molecular Identification of from Ticks Parasitizing Domestic and Wild Animals in South Korea.

Microorganisms 2020 Apr 29;8(5). Epub 2020 Apr 29.

College of Veterinary Medicine, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Korea.

Lyme borreliosis is one of the most prevalent tick-borne infectious zoonotic diseases caused by spirochetes of the sensu lato group. The present study assessed the risk factors and prevalence of Lyme borreliosis in ticks parasitizing domestic and wild animals. A total of 589 ticks (329 tick pools) collected from animals were identified as , (85. Read More

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http://dx.doi.org/10.3390/microorganisms8050649DOI Listing

Identification of the proteins of Borrelia garinii interacting with human brain microvascular endothelial cells.

Ticks Tick Borne Dis 2020 Jul 21;11(4):101451. Epub 2020 Apr 21.

Laboratory of Biomedical Microbiology and Immunology, The University of Veterinary Medicine and Pharmacy in Košice, Komenskeho 73, 04001, Kosice, Slovakia; Institute of Neuroimmunology of Slovak Academy of Sciences, 84510, Bratislava, Slovakia. Electronic address:

Lyme borreliosis is one of the major tick-borne diseases in Europe. Events of the translocation of Borrelia across the blood-brain barrier (BBB) involve multiple interactions between borrelial surface proteins and receptors on the brain microvascular endothelial cells (hBMECs). In this study, we aimed to identify proteins of Borrelia that plausibly interact with hBMECs. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101451DOI Listing

Managing patients with COVID-19 infections: a first-hand experience from the Wuhan Mobile Cabin Hospital.

Br J Gen Pract 2020 05 30;70(694):229-230. Epub 2020 Apr 30.

Department of Respiratory and Critical Care Medicine, East District of the First Affiliated Hospital of Anhui Medical University (Feidong People's Hospital), Feidong, China; Wuhan Sports Stadium Mobile Cabin Hospital, Wuhan, China. Email:

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http://dx.doi.org/10.3399/bjgp20X709529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194767PMC
May 2020
2.356 Impact Factor

: Vector to an Increasing Diversity of Human Pathogens in the Upper Midwest.

WMJ 2020 Mar;119(1):16-21

Department of Microbiology, University of Wisconsin-La Crosse, La Crosse, Wisconsin,

Introduction: The black-legged tick, , is now recognized as the deadliest tick vector in the United States. The Upper Midwest, particularly Wisconsin and Minnesota, are endemic to a diversity of tick-transmitted infectious diseases. Although , the agent of Lyme disease, still accounts for the majority of diagnosed infections, is known to transmit other bacterial, viral, and parasitic agents. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209771PMC

Climatic changes and their role in emergence and re-emergence of diseases.

Environ Sci Pollut Res Int 2020 Apr 28. Epub 2020 Apr 28.

Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Global warming and the associated climate changes are predictable. They are enhanced by burning of fossil fuels and the emission of huge amounts of CO gas which resulted in greenhouse effect. It is expected that the average global temperature will increase with 2-5 °C in the next decades. Read More

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http://dx.doi.org/10.1007/s11356-020-08896-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187803PMC

Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.

Ger Med Sci 2020 27;18:Doc03. Epub 2020 Feb 27.

German Society of Neurology (DGN), Berlin, Germany.

Lyme borreliosis is the most common tick-borne infectious disease in Europe. A neurological manifestation occurs in 3-15% of infections and can manifest as polyradiculitis, meningitis and (rarely) encephalomyelitis. This S3 guideline is directed at physicians in private practices and clinics who treat Lyme neuroborreliosis in children and adults. Read More

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http://dx.doi.org/10.3205/000279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174852PMC
February 2020

Sharing the Ride: Symbionts and Their Interactions.

Front Cell Infect Microbiol 2020 8;10:142. Epub 2020 Apr 8.

Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

The deer tick transmits a variety of disease agents in the United States, spreading the bacteria that causes Lyme borreliosis, the protozoan agent of babesiosis, and viruses such as Powassan. However, a variety of other organisms have also evolved symbiotic relationships with this tick species, and it seems likely that some of these microbes have simultaneously coevolved mechanisms to impact each other and their tick host. The number of organisms identified as symbionts has increased seemingly exponentially with the advent of PCR and next generation sequencing technologies, but convincing arguments have proposed that some of these are of environmental origin, unadapted to surviving the physiological conditions of the tick or that they are artifacts of ultrasensitive detection methods. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156593PMC

Rejection of the name and all proposed species comb. nov. placed therein.

Int J Syst Evol Microbiol 2020 May;70(5):3577-3581

Members of the ESCMID Study Group for Lyme Borreliosis (ESGBOR, www.escmid.org/esgbor).

Rejection () of the name and all new combinations therein is being requested on grounds of risk to human health and patient safety (Principle 1, subprinciple 2 and Rule 56a) and violation to aim for stability of names, to avoid useless creation of names (Principle 1, subprinciple 1 and 3) and that names should not be changed without sufficient reason (Principle 9 of the International Code of Nomenclature of Prokaryotes). Read More

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http://dx.doi.org/10.1099/ijsem.0.004149DOI Listing

Rapid clearance of Borrelia burgdorferi from the blood circulation.

Parasit Vectors 2020 Apr 21;13(1):191. Epub 2020 Apr 21.

Bacteriology and Mycology, Institute for Infectious Diseases and Zoonoses, Department of Veterinary Science, Faculty of Veterinary Medicine, LMU Munich, Munich, Germany.

Background: Borrelia burgdorferi is a tick-borne spirochete that causes Lyme borreliosis (LB). After an initial tick bite, it spreads from the deposition site in the dermis to distant tissues of the host. It is generally believed that this spirochete disseminates via the hematogenous route. Read More

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http://dx.doi.org/10.1186/s13071-020-04060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171858PMC

Assessment of Borrelia miyamotoi in febrile patients and ticks in Alsace, an endemic area for Lyme borreliosis in France.

Parasit Vectors 2020 Apr 17;13(1):199. Epub 2020 Apr 17.

University of Strasbourg, Virulence bactérienne précoce UR7290-Lyme borreliosis group, FMTS - CHRU Strasbourg, Institut de Bactériologie, Strasbourg, France.

Background: Borrelia miyamotoi is a relapsing fever Borrelia species transmitted by ticks of the Ixodes ricinus complex. Human disease caused by B. miyamotoi was first described in Russia and later in the USA and Japan. Read More

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http://dx.doi.org/10.1186/s13071-020-04071-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165395PMC

A painless erythematous swelling of the external ear as a manifestation of Lyme disease: a case report.

J Med Case Rep 2020 Apr 16;14(1):48. Epub 2020 Apr 16.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH, 45229-3039, USA.

Background: Lyme disease is the most common tick-borne illness in the USA, Canada, and Europe. Clinical manifestations vary greatly, with localized skin findings functioning as early signs of the disease, followed by disseminated disease. The rarest dermatologic presentation of Lyme is a borrelial lymphocytoma, occurring distinctly in Europe and caused typically by Borrelia afzelii. Read More

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http://dx.doi.org/10.1186/s13256-020-02377-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161252PMC

Prevalence and Coinfection of Three Tick-Borne Pathogens in Questing Adult Blacklegged Ticks (Vilas County, Wisconsin).

Vector Borne Zoonotic Dis 2020 Apr 13. Epub 2020 Apr 13.

Department of Biological Sciences, Wright State University, Dayton, Ohio.

In North America, the blacklegged tick () is a vector of several human pathogens, and tick-borne disease incidence is increasing. We estimated the prevalence of questing blacklegged ticks vectoring three zoonotic pathogens in Vilas County, Wisconsin. We collected 461 adult blacklegged ticks and used PCR to screen for the presence of pathogens that cause Lyme disease (), human granulocytic anaplasmosis (HGA, ), and babesiosis (). Read More

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http://dx.doi.org/10.1089/vbz.2020.2619DOI Listing

Protective Effectiveness of Long-Lasting Permethrin Impregnated Clothing Against Tick Bites in an Endemic Lyme Disease Setting: A Randomized Control Trial Among Outdoor Workers.

J Med Entomol 2020 Apr 11. Epub 2020 Apr 11.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.

Tick-borne diseases are a growing threat to public health in the United States, especially among outdoor workers who experience high occupational exposure to ticks. Long-lasting permethrin-impregnated clothing has demonstrated high initial protection against bites from blacklegged ticks, Ixodes scapularis Say (Acari: Ixodidae), in laboratory settings, and sustained protection against bites from the lone star tick, Amblyomma americanum (L.) (Acari: Ixodidae), in field tests. Read More

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http://dx.doi.org/10.1093/jme/tjaa061DOI Listing

Transovarial transmission of Borrelia spp., Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus under field conditions extrapolated from DNA detection in questing larvae.

Parasit Vectors 2020 Apr 7;13(1):176. Epub 2020 Apr 7.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hanover, Germany.

Background: Ixodes ricinus constitutes the main European vector tick for the Lyme borreliosis pathogen Borrelia burgdorferi (sensu lato), the relapsing fever borrelia Borrelia miyamotoi, as well as Anaplasma phagocytophilum and several Rickettsia species. Under laboratory conditions, a transovarial transmission to the next tick generation is described for Rickettsia spp. and Borrelia spp. Read More

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http://dx.doi.org/10.1186/s13071-020-04049-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140504PMC

Missing the Target.

N Engl J Med 2020 04;382(14):1353-1359

From the Departments of Medicine (C.I., F.M.M., A.L.M., J.L.) and Neurology (H.V.), Brigham and Women's Hospital, and the Departments of Medicine (C.I., F.M.M., A.L.M., J.L.) and Neurology (H.V.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1901669DOI Listing

[Lyme Borreliosis in 2020 practice, from a dermatological point of view].

Rev Med Suisse 2020 Apr;16(688):629-634

Service de dermatologie, Département de médecine, HUG, 1211 Genève 14.

Lyme borreliosis is a frequent disease in Switzerland. Due to the increasing number of symptoms attributed to this infection, the diagnostic is often controversy between different specialists and is often a subject of discussion. The diagnostic of Lyme disease lays particularly on the knowledge of cutaneous signs which are the only specific. Read More

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Tick-Borne Diseases in the United States.

Clin Chem 2020 Apr;66(4):537-548

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Background: Tick-borne diseases are an important cause of human morbidity and mortality in the United States. The past several decades have witnessed an increase in both the number of recognized tick-borne pathogens and the number of tick-borne disease cases, whereas tick surveys have revealed substantial geographic expansions of tick populations throughout the country. Multiple laboratory testing options exist for diagnosis of tick-borne diseases, including serology, microscopy, and molecular-based methods. Read More

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http://dx.doi.org/10.1093/clinchem/hvaa040DOI Listing

An Overview of Tickborne Infections in Pregnancy and Outcomes in the Newborn: The Need for Prospective Studies.

Authors:
John S Lambert

Front Med (Lausanne) 2020 6;7:72. Epub 2020 Mar 6.

Infectious Diseases Department, Mater Misericordiae University Hospital, Dublin, Ireland.

Tick-borne infections are an ever-increasing issue internationally, many factors contribute to this including a changing climate. Pregnant women represent the single largest vulnerable group in populations due to a relative immune deficiency status. Infections in pregnant women have the added gravity of potential infection in the developing fetus which may have catastrophic consequences including death or lifelong debilitation. Read More

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http://dx.doi.org/10.3389/fmed.2020.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069275PMC

Emerging tick-borne diseases and blood safety: summary of a public workshop.

Transfusion 2020 Mar 24. Epub 2020 Mar 24.

Product Review Branch, Division of Emerging & Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food & Drug Administration, Silver Spring, Maryland, USA.

Tick-borne agents of disease continue to emerge and subsequently expand their geographic distribution. The threat to blood safety by tick-borne agents is ever increasing and requires constant surveillance concomitant with implementation of appropriate intervention methods. In April 2017, the Food and Drug Administration organized a public workshop on emerging tick-borne pathogens (excluding Babesia microti and Lyme disease) designed to provide updates on the current understanding of emerging tick-borne diseases, thereby allowing for extended discussions to determine if decisions regarding mitigation strategies need to be made proactively. Read More

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http://dx.doi.org/10.1111/trf.15752DOI Listing

[Second-degree atrioventricular block caused by Lyme disease].

Ned Tijdschr Geneeskd 2020 Jan 24;164. Epub 2020 Jan 24.

Amsterdam UMC, Afd. Interne Geneeskunde.

Background: Tick-borne diseases, including Lyme disease, are becoming increasingly common in Europe. Lyme disease has a wide variety of clinical manifestations, as a result of which physicians of diverse disciplines are coming into contact with such patients.

Case Description: A 58-year-old man was seen at the emergency room with a symptomatic Wenckebach-type second-degree atrioventricular (AV) block and periods of 2:1 AV block. Read More

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January 2020

Stemming the Rising Tide of Human-Biting Ticks and Tickborne Diseases, United States.

Authors:
Lars Eisen

Emerg Infect Dis 2020 Apr;26(4):641-647

Ticks and tickborne diseases are increasingly problematic. There have been positive developments that should result in improved strategies and better tools to suppress ticks, reduce human tick bites, and roll back tickborne diseases. However, we equally need to address the question of who is responsible for implementing the solutions. Read More

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http://dx.doi.org/10.3201/eid2604.191629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101104PMC

Global Transcriptome Analysis Identifies a Diagnostic Signature for Early Disseminated Lyme Disease and Its Resolution.

mBio 2020 Mar 17;11(2). Epub 2020 Mar 17.

Department of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, New York, USA.

A bioinformatics approach was employed to identify transcriptome alterations in the peripheral blood mononuclear cells of well-characterized human subjects who were diagnosed with early disseminated Lyme disease (LD) based on stringent microbiological and clinical criteria. Transcriptomes were assessed at the time of presentation and also at approximately 1 month (early convalescence) and 6 months (late convalescence) after initiation of an appropriate antibiotic regimen. Comparative transcriptomics identified 335 transcripts, representing 233 unique genes, with significant alterations of at least 2-fold expression in acute- or convalescent-phase blood samples from LD subjects relative to healthy donors. Read More

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http://dx.doi.org/10.1128/mBio.00047-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078463PMC

Lyme neuroborreliosis in adults: A nationwide prospective cohort study.

Ticks Tick Borne Dis 2020 Jul 24;11(4):101411. Epub 2020 Feb 24.

Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

The goal of this paper is to characterize the clinical presentation, serological results, current antibiotic treatment practice, including compliance with current European guidelines, and outcome in adults with Lyme neuroborreliosis (LNB) diagnosed at departments of infectious diseases in Denmark. Using a nationwide prospective cohort of patients with central nervous system infections, we identified all adults (≥ 18 years of age) treated for LNB at departments of infectious diseases in Denmark from 2015 through 2017. The database contains information on baseline demographics, history of tick bite, erythema migrans, clinical presentation, laboratory results of blood samples, and cerebrospinal (CSF) biochemistry (e. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101411DOI Listing

Management Options for -Associated Pathogens: A Review of Prevention Strategies.

Int J Environ Res Public Health 2020 03 12;17(6). Epub 2020 Mar 12.

Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice 370 05, Czech Republic.

Ticks are important human and animal parasites and vectors of many infectious disease agents. Control of tick activity is an effective tool to reduce the risk of contracting tick-transmitted diseases. The castor bean tick () is the most common tick species in Europe. Read More

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http://dx.doi.org/10.3390/ijerph17061830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143654PMC

Doxycycline for Prevention of Spirochetal Infections-Status Report.

Authors:
Gary P Wormser

Clin Infect Dis 2020 Mar 11. Epub 2020 Mar 11.

Division of Infectious Diseases, New York Medical College, Valhalla, NY.

Important human infections caused by spirochetal microorganisms include Lyme disease, syphilis, leptospirosis, and tick-borne relapsing fever. Doxycycline prophylactic regimens have been shown to significantly reduce the risk for developing all of these infections in potentially exposed individuals, which is highly clinically relevant since no vaccines to prevent these infections in humans are currently available. Additional data, however, are needed to define more precisely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and syphilis, infections that can be potentially prevented by a single 200 mg dose of doxycycline given within 72 hours post-exposure. Read More

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http://dx.doi.org/10.1093/cid/ciaa240DOI Listing

Patient-reported outcome after treatment for definite Lyme neuroborreliosis.

Brain Behav 2020 Apr 9;10(4):e01595. Epub 2020 Mar 9.

The Norwegian National Advisory Unit on Tick-borne Diseases, Arendal, Norway.

Objective: To chart patient-reported outcome measures (PROMs) in Norwegian patients treated for definite neuroborreliosis (NB).

Material And Methods: Adult patients treated for definite NB 1-10 years earlier supplied demographics, symptoms and treatment during NB, and answered validated questionnaires; Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), health-related quality of life questionnaire (RAND-36), and Patient Health Questionnaire (PHQ-15).

Results: A higher proportion of NB-treated persons reported severe fatigue, defined as FSS score ≥ 5, than in Norwegian normative data, but when removing persons with confounding fatigue associated comorbidities (n = 69) from the analyses, there was no difference between groups. Read More

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http://dx.doi.org/10.1002/brb3.1595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177557PMC

Epidemiology of Lyme Disease in a Highly Endemic European Zone.

Medicina (Kaunas) 2020 Mar 5;56(3). Epub 2020 Mar 5.

State Research Institute Centre for Innovative Medicine, 08410 Vilnius, Lithuania.

Lyme disease, also known as Lyme borreliosis (LB), is a tick-borne infectious disease caused by the spirochete bacteria Borrelia. The risk of infection depends on the geographical area, ecological factors, and human behavior. Clinical manifestations of Lyme borreliosis have a wide range, but the most frequent clinical symptom, which is also a diagnostic symptom, is a skin rash called erythema migrans (EM). Read More

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http://dx.doi.org/10.3390/medicina56030115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143858PMC

Lyme disease: implications for general practice.

Authors:
Victoria Cairns

Br J Gen Pract 2020 03 27;70(692):106-107. Epub 2020 Feb 27.

Oxford, UK.

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http://dx.doi.org/10.3399/bjgp20X708341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038844PMC

New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle.

Front Cell Infect Microbiol 2020 30;10. Epub 2020 Jan 30.

Institute of Medical Microbiology and Infection Control, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.

Lyme disease (LD), which is caused by genospecies of the sensu lato complex, is the most common vector-borne disease in the Northern hemisphere. Spirochetes are transmitted by ticks and maintained in diverse vertebrate animal hosts. Following tick bite, spirochetes initially establish a localized infection in the skin. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002432PMC
January 2020

Vector competence studies with hard ticks and Borrelia burgdorferi sensu lato spirochetes: A review.

Authors:
Lars Eisen

Ticks Tick Borne Dis 2020 May 14;11(3):101359. Epub 2019 Dec 14.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, United States. Electronic address:

Use of emerging technology allowing for identification of genetic material from pathogens and endosymbionts in ticks collected from humans, domestic animals, wildlife, or the environment has resulted in an avalanche of new data on tick-microorganism associations. This rapidly growing stream of new information is a tremendous resource but also presents challenges, including how detection of pathogen genetic material in ticks should best be interpreted. There is a tendency in the more recent published literature to incorrectly use the term "vector" based on detection of pathogen genetic material from tick species not experimentally confirmed to serve as vectors of the pathogen in question. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.101359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127979PMC

Lymelight: forecasting Lyme disease risk using web search data.

NPJ Digit Med 2020 4;3:16. Epub 2020 Feb 4.

1Google, Mountain View, CA USA.

Lyme disease is the most common tick-borne disease in the Northern Hemisphere. Existing estimates of Lyme disease spread are delayed a year or more. We introduce Lymelight-a new method for monitoring the incidence of Lyme disease in real-time. Read More

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http://dx.doi.org/10.1038/s41746-020-0222-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000681PMC
February 2020

Ticks on the Channel Islands and implications for public health.

Ticks Tick Borne Dis 2020 May 4;11(3):101405. Epub 2020 Feb 4.

Medical Entomology and Zoonoses Ecology, Emergency Response Department, Public Health England, Porton Down, Salisbury, SP4 0JG, UK; NIHR Health Protection Research Unit in Environmental Change and Health, UK; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, UK.

The Channel Islands are British Crown dependencies located in the English Channel to the west of the Normandy coast in northern France. Whilst there have been studies investigating tick occurrence and distribution in different habitats on the mainland of the UK and in France, the Channel Islands have been relatively understudied. As such, little is known about whether the sheep tick, Ixodes ricinus, is present, and whether there is a potential risk of Lyme borreliosis on the Channel Islands. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101405DOI Listing

A fluorescent plasmonic biochip assay for multiplex screening of diagnostic serum antibody targets in human Lyme disease.

PLoS One 2020 10;15(2):e0228772. Epub 2020 Feb 10.

College of Nanoscale Science & Engineering, State University of New York Polytechnic Institute, Albany, New York, United States of America.

Lyme disease (LD) diagnosis using the current two-tier algorithm is constrained by low sensitivity for early-stage infection and ambiguity in determining treatment response. We recently developed a protein microarray biochip that measures diagnostic serum antibody targets using grating-coupled fluorescent plasmonics (GC-FP) technology. This strategy requires microliters of blood serum to enable multiplexed biomarker screening on a compact surface and generates quantitative results that can be further processed for diagnostic scoring. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010292PMC

Borrelia burgdorferi hijacks cellular metabolism of immune cells: Consequences for host defense.

Ticks Tick Borne Dis 2020 May 3;11(3):101386. Epub 2020 Feb 3.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Changes in cellular metabolism have proven to be important factors in driving cell behavior. It has been shown that cellular metabolism of immune cells changes when exposed to or infected by several pathogens: while this is often an adaptation of the host cells to the infection, sometimes it represents a mechanism through which the pathogens evade immune activation. Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis, is a pathogen that highly depends on the host to survive, as the bacterium lacks many central metabolic pathways to generate its own nutrients. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101386DOI Listing

Detection of Ehrlichia spp. and Anaplasma phagocytophilum in whole blood specimens using a duplex real-time PCR assay on the ARIES instrument.

Ticks Tick Borne Dis 2020 May 1;11(3):101387. Epub 2020 Feb 1.

University of Louisville, Department of Medicine, Division of Infectious Diseases, Infectious Diseases Laboratory, 511 S. Floyd St, Medical Dental Research Building Room 104, Louisville, KY 40292 USA. Electronic address:

Cases of tick-borne diseases are increasing in the United States, and new tick-borne pathogen species causing human illness are being discovered. The specific etiology is generally difficult to diagnose based on clinical signs and symptoms alone, because of their generalized nature and often lack of a known tick bite. For some infections, such as Lyme disease and spotted fever group rickettsioses, serology remains the most appropriate laboratory diagnostic tool, but for others such as anaplasmosis, ehrlichiosis, and babesiosis, direct detection in the blood is preferred for rapid diagnosis. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2020.101387DOI Listing

Potential impact of IVIG treatment on Lyme serology.

Diagn Microbiol Infect Dis 2020 04 10;96(4):114986. Epub 2020 Jan 10.

Central Hospital of Southern Pest, National Institute of Hematology and Infectology, Central Laboratory, 5-7 Albert Flórián Road, 1097 Budapest, Hungary.

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http://dx.doi.org/10.1016/j.diagmicrobio.2020.114986DOI Listing