10,863 results match your criteria Tick-Borne Diseases Lyme


Borrelia burgdorferi basic membrane protein A initiates proinflammatory chemokine storm in THP 1-derived macrophages via the receptors TLR1 and TLR2.

Biomed Pharmacother 2019 Apr 16;115:108874. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, China.

Lyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an important role in Lyme arthritis. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108874DOI Listing
April 2019
2 Reads

Erythema Migrans-Like Rash Mimicking Lyme Disease.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Japan.

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2635-19DOI Listing
April 2019
1 Read

Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate).

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

Institute of Parasitology, Biology Centre, Academy of Sciences of Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic.

In Europe, Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are the two vector-borne diseases with the largest impact on human health. Based on data on the density of host-seeking ticks and pathogen prevalence and using a variety of environmental data, we have created an acarological risk model for a region where both diseases are endemic (Czech Republic-South Bohemia and Germany-Lower Bavaria, Upper Palatinate). The data on tick density were acquired by flagging 50 sampling sites three times in a single season. Read More

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http://dx.doi.org/10.3390/ijerph16071173DOI Listing
April 2019
1 Read

Ticks and tick-borne diseases in the city: Role of landscape connectivity and green space characteristics in a metropolitan area.

Sci Total Environ 2019 Mar 16;670:941-949. Epub 2019 Mar 16.

Department of Biology, University of Antwerp, Wilrijk, Belgium.

Green spaces in the city are important for human wellbeing, but are also zones in which humans can become infected with zoonotic diseases. Therefore, there is a need to understand how infection risk is related to green space characteristics, wildlife communities and connectivity with rural areas hosting reservoir populations of hosts. Our hypothesis is that wildlife hosts in urban green spaces, and thereby the prevalence of questing ticks and their Lyme disease causing pathogens (Borrelia burgdorferi s. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.235DOI Listing
March 2019
2 Reads

Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".

Recent Pat Antiinfect Drug Discov 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat-382481. India.

Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Read More

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http://dx.doi.org/10.2174/1574891X14666190327114641DOI Listing
March 2019
1 Read

Geographical Features and Seroprevalence of in Erzincan, Turkey.

J Arthropod Borne Dis 2018 Dec 25;12(4):378-386. Epub 2018 Dec 25.

Department of Geography, Faculty of Arts and Sciences, Erzincan University, Erzincan, Turkey.

Background: We aimed to determine the geographical features and seroprevalence of in Erzincan, Turkey, which has a high tick population due to its geographical position and climatic conditions.

Methods: From January to December 2014, 368 people living in Erzincan, northeastern Turkey were enrolled. IgG antibodies were investigated in the collected serum samples using the ELISA method in 2015. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423460PMC
December 2018
3 Reads

Presence of and Sensu Stricto in a Tick and Dual Parasitism of and on a Bird in Canada.

Healthcare (Basel) 2019 Mar 20;7(1). Epub 2019 Mar 20.

Department of Biology, Georgia Southern University, Statesboro, GA 30458, USA.

Wild birds transport ticks into Canada that harbor a diversity of zoonotic pathogens. However, medical practitioners often question how these zoonotic pathogens are present in their locality. In this study, we provide the first report of an tick cofeeding with a blacklegged tick, , which parasitized a Veery, -a neotropical songbird. Read More

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http://dx.doi.org/10.3390/healthcare7010046DOI Listing
March 2019
1 Read

The effects of multiyear and seasonal weather factors on incidence of Lyme disease and its vector in New York State.

Sci Total Environ 2019 May 8;665:1182-1188. Epub 2019 Feb 8.

Department of Epidemiology and Biostatistics, University at Albany, State University at New York, Rensselaer, NY, United States of America; Investigations and Vector Surveillance Units, Bureau of Communicable Disease Control, New York State Department of Health, Albany, NY, United States of America.

Background: More frequent extreme weather and warmer weather due to climate change might change the spatiotemporal distributions of vector-borne diseases, including Lyme disease. However, limited studies have examined the associations of Lyme disease and its vectors with weather factors, especially multi-year and multi-weather factors related to vector life cycle.

Objectives: We investigated the associations between multi-year, unique weather indicators (relevant to tick and host activities) and Lyme disease incidence or documented I. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.123DOI Listing
May 2019
2 Reads

Geographic Range of Lyme Borreliosis in Mongolia.

Vector Borne Zoonotic Dis 2019 Mar 5. Epub 2019 Mar 5.

2 National Center for Zoonotic Diseases, Ulaanbaatar, Mongolia.

Introduction: In Asia, Borrelia garinii, B. afzelii, and B. bavariensis are transmitted by Ixodes persulcatus ticks and clinically present with a wide range of neurological and arthritic symptoms. Read More

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http://dx.doi.org/10.1089/vbz.2018.2421DOI Listing
March 2019
6 Reads

[A "new" look at "old" borreliosis].

Authors:
Tadeusz Płusa

Pol Merkur Lekarski 2019 Feb;46(272):55-59

Medical Faculty of Łazarski University in Warsaw.

The threat of borreliosis is a growing medical problem. The number of cases is constantly increasing, and the diagnostic methods and recommended treatment methods do not bring new values in comparison to the findings from over 30 years ago. Among the pathogens transmitted by ticks, apart from Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia species, Neoehrlichia mikurensis, as well as fever caused by rickettsiae and others, are referred to as "emerging" or "rediscovered". Read More

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February 2019
7 Reads

Detection of antibodies to Borrelia burgdorferi s.l. in wild small mammals and sensitivity of PCR and cultivation.

Vet Microbiol 2019 Mar 4;230:241-243. Epub 2019 Feb 4.

Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, 612 42 Brno, Czech Republic. Electronic address:

The aim of this study was to determine the seroprevalence of antibodies to B. burgdorferi s.l. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.02.004DOI Listing
March 2019
4 Reads

A framework for adaptive surveillance of emerging tick-borne zoonoses.

One Health 2019 Jun 11;7:100083. Epub 2019 Feb 11.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.

Significant global ecological changes continue to drive emergence of tick-borne zoonoses around the world. This poses an important threat to both human and animal health, and highlights the need for surveillance systems that are capable of monitoring these complex diseases effectively across different stages of the emergence process. Our objective was to develop an evidence-based framework for surveillance of emerging tick-borne zoonoses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23527714183004
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http://dx.doi.org/10.1016/j.onehlt.2019.100083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376153PMC
June 2019
4 Reads

Lyme disease overdiagnosis in a large healthcare system: a population-based, retrospective study.

Clin Microbiol Infect 2019 Feb 22. Epub 2019 Feb 22.

Public Health and Preventive Medicine Department, U.S. Air Force School of Aerospace Medicine, Wright-Patterson AFB, OH, USA.

Objectives: To evaluate the impact of false-positive IgM immunoblots on Lyme disease treatment and case reporting in a large healthcare system.

Methods: We obtained the results of all Lyme disease serological tests ordered at U.S. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.020DOI Listing
February 2019
4 Reads

Implementation of preventive measures against tick-borne infections in a non-endemic area for tick-borne encephalitis-Results from a population-based survey in Lower Saxony, Germany.

Ticks Tick Borne Dis 2019 04 16;10(3):614-620. Epub 2019 Feb 16.

Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany; German Center for Infection Research (DZIF), Hannover-Braunschweig, Germany; Institute of Epidemiology and Social Medicine, University of Münster, Domagkstraße 3, 48149, Münster, Germany. Electronic address:

Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are the most common tick-borne diseases in Germany. While for LB only non-specific prevention strategies exist, TBE can be additionally prevented by vaccination. It is unclear to which extent non-specific prevention strategies are applied by individuals living in non-endemic areas for TBE in Germany, and whether TBE vaccination status affects their implementation. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.005DOI Listing
April 2019
4 Reads

Ixodes ricinus infesting snakes: Insights on a new tick-host association in a Borrelia burgdorferi sensu lato endemic area.

Acta Trop 2019 May 19;193:35-37. Epub 2019 Feb 19.

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, 70010 Valenzano, Italy. Electronic address:

The castor bean tick Ixodes ricinus is one of the most abundant tick species in Europe, being able to parasitize a wide number of vertebrate hosts, including mammals, birds, and reptiles. This tick species has an important role as vector of zoonotic pathogens, including the causative agents of Lyme borreliosis (i.e. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.021DOI Listing
May 2019
1 Read

Detection of municipalities at-risk of Lyme disease using passive surveillance of Ixodes scapularis as an early signal: A province-specific indicator in Canada.

PLoS One 2019 19;14(2):e0212637. Epub 2019 Feb 19.

Policy Integration and Zoonoses Division, Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, Québec, Canada.

Lyme disease, the most commonly reported vector-borne disease in North America, is caused by the spirochete Borrelia burgdorferi sensu stricto, which is transmitted by Ixodes scapularis in eastern Canada and Ixodes pacificus in western Canada. Recently, the northward range expansion of I. scapularis ticks, in south-eastern Canada, has resulted in a dramatic increase in the incidence of human Lyme disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380584PMC
February 2019
6 Reads

Association of small fiber neuropathy and post treatment Lyme disease syndrome.

PLoS One 2019 12;14(2):e0212222. Epub 2019 Feb 12.

Dean Center for Tick Borne Illness, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

Objectives: To examine whether post-treatment Lyme disease syndrome (PTLDS) defined by fatigue, cognitive complaints and widespread pain following the treatment of Lyme disease is associated with small fiber neuropathy (SFN) manifesting as autonomic and sensory dysfunction.

Methods: This single center, retrospective study evaluated subjects with PTLDS. Skin biopsies for assessment of epidermal nerve fiber density (ENFD), sweat gland nerve fiber density (SGNFD) and functional autonomic testing (deep breathing, Valsalva maneuver and tilt test) were performed to assess SFN, severity of dysautonomia and cerebral blood flow abnormalities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212222PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372188PMC
February 2019
11 Reads

[Guideline for the diagnosis and treatment of Lyme borreliosis].

Klin Mikrobiol Infekc Lek 2018 09;24(3):88-99

Department of Children's Infectious Diseases, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic, e-mail:

The national guideline aims to highlight the latest knowledge about clinical manifestations of the infection, to summarize the diagnostic algorithm and to recommend the appropriate antibiotic therapy with respect to evidence-based medicine. The recommendations are consistent with most European guidelines as well as those published by the IDSA. The guideline provides the most recent information on the epidemiology, etiology and pathogenesis of Lyme borreliosis, dermatological, neurological and musculoskeletal involvement, the appropriate diagnostic procedure and prevention. Read More

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September 2018
7 Reads

Human Tick-Borne Diseases in Australia.

Front Cell Infect Microbiol 2019 28;9. Epub 2019 Jan 28.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

There are 17 human-biting ticks known in Australia. The bites of , and can cause paralysis, inflammation, and severe local and systemic reactions in humans, respectively. Six ticks, including , and may transmit , or subsp. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360175PMC
January 2019
7 Reads

Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs.

Transbound Emerg Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas.

Tick-borne diseases (TBD), caused by borrelial, rickettsial and babesial pathogens, are common across the United States and can cause severe clinical disease in susceptible hosts, such as domestic dogs. However, there are limited TBD molecular epidemiological reports for dogs in Texas, and none for the non-Lyme borrelial pathogen responsible for causing tick-borne relapsing fever (TBRF). Therefore, data to support the prevalence of TBRF in the canine population is inadequate. Read More

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http://doi.wiley.com/10.1111/tbed.13145
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http://dx.doi.org/10.1111/tbed.13145DOI Listing
February 2019
16 Reads

Ticks and tick-borne diseases.

Med Mal Infect 2019 Mar 6;49(2):87-97. Epub 2019 Feb 6.

Service des maladies infectieuses et tropicales, Hôpitaux Universitaires de Strasbourg, Fédération de Médecine translationnelle de Strasbourg, Membre du groupe ESGBOR de l'ESCMID, 67000 Strasbourg, France.

Ticks are a major group of arthropod vectors, characterized by the diversity of pathogens they transmit, by their impact on human and animal health, and by their socioeconomic implication especially in countries of the Southern Hemisphere. In Europe, Ixodes is the most important tick due to its wide distribution in the ecosystems and the variety of transmitted pathogens, in particular Borrelia (responsible for Lyme borreliosis), but also the tick-borne encephalitis virus. Their increased presence in the environment since the beginning of the 20th century is undeniable, because of major modifications in the biodiversity caused by humans. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.007DOI Listing
March 2019
6 Reads

Nymphal Ixodes scapularis questing behavior explains geographic variation in Lyme borreliosis risk in the eastern United States.

Ticks Tick Borne Dis 2019 04 19;10(3):553-563. Epub 2019 Jan 19.

Center for Wildlife Health, University of Tennessee Institute of Agriculture, Knoxville, TN, 37996, USA. Electronic address:

Most people who contract Lyme borreliosis in the eastern United States (US) acquire infection from the bite of the nymphal life stage of the vector tick Ixodes scapularis, which is present in all eastern states. Yet <5% of Lyme borreliosis cases are reported from outside the north-central and northeastern US. Geographical differences in nymphal questing (i. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.01.001DOI Listing
April 2019
2 Reads

Scaling of Host Competence.

Trends Parasitol 2019 03 29;35(3):182-192. Epub 2019 Jan 29.

Global and Planetary Health, University of South Florida, Tampa, FL 33620, USA.

Body size influences many traits including those that affect host competence, the propensity to cause new infections. Here, we employ a new framework to reveal that, for at least two infections, West Nile virus and Lyme disease, large hosts should be more competent than small ones, but their lower abundance could mitigate their impacts on local risk. By contrast, for rabies, small hosts will be disproportionately more competent than large ones, an effect amplified by the higher densities of small species. Read More

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http://dx.doi.org/10.1016/j.pt.2018.12.002DOI Listing
March 2019
4 Reads

Prevalence of Borrelia burgdorferi, Anaplasma spp., Ehrlichia spp. and Dirofilaria immitis in Canadian dogs, 2008 to 2015: a repeat cross-sectional study.

Parasit Vectors 2019 Jan 28;12(1):64. Epub 2019 Jan 28.

University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Background: Vector-borne pathogens are emerging concerns in multiple regions of Canada. Determining regional prevalence of canine vector-borne pathogens and documenting change will improve clinician awareness, enable targeted prevention, enhance diagnosis and ideally reduce the risk of disease. Study objectives were to: (i) estimate the prevalence of positive canine vector-borne test results from samples submitted in Canada; (ii) assess change in prevalence over time, from baseline (2008) to 2015; and (iii) estimate the prevalence of pathogen co-infections. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-019-3299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350403PMC
January 2019
9 Reads

Lyme Disease Emergence after Invasion of the Blacklegged Tick, Ixodes scapularis, Ontario, Canada, 2010-2016.

Emerg Infect Dis 2019 02;25(2):328-332

Analysis of surveillance data for 2010-2016 in eastern Ontario, Canada, demonstrates the rapid northward spread of Ixodes scapularis ticks and Borrelia burgdorferi, followed by increasing human Lyme disease incidence. Most spread occurred during 2011-2013. Continued monitoring is essential to identify emerging risk areas in this region. Read More

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http://dx.doi.org/10.3201/eid2502.180771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346472PMC
February 2019
6 Reads

Opsoclonus in a child with neuroborreliosis: Case report and review of the literature.

Arch Pediatr 2019 Feb 14;26(2):118-119. Epub 2019 Jan 14.

Service de neurologie pédiatrique, CHU d'Angers, 4, rue Larrey, 49100 Angers, France.

Opsoclonus consists of massive erratic rapid eye jerks. They may occur in isolation or in association with myoclonus and ataxia, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0929693X183026
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http://dx.doi.org/10.1016/j.arcped.2018.11.013DOI Listing
February 2019
8 Reads

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea.

Korean J Parasitol 2018 Dec 31;56(6):609-613. Epub 2018 Dec 31.

Department of Internal Medicine, Inha University School of Medicine, Incheon 22212, Korea.

Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.6.609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327201PMC
December 2018
6 Reads

Comparison of the epidemiological patterns of Lyme borreliosis and tick-borne encephalitis in the Czech Republic in 2007-2016.

Epidemiol Mikrobiol Imunol Winter 2018;67(3):134-140

Background: Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are two vector-borne diseases transmitted by ticks. Both diseases are endemic and have been reported in all regions of the Czech Republic including urban agglomerations, but in varying proportions. Because of the natural conditions in the border areas, the risk of infection is also high for travelers from the neighboring countries such as Austria, Germany, Poland, and Slovakia. Read More

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April 2019
2 Reads

Dissociating effect of salivary gland extract from Ixodes ricinus on human fibroblasts: Potential impact on Borrelia transmission.

Ticks Tick Borne Dis 2019 02 23;10(2):433-441. Epub 2018 Dec 23.

EA7290, Virulence bactérienne précoce, groupe Borréliose de Lyme, Facultés de médecine et de pharmacie, Université de Strasbourg, France. Electronic address:

Understanding the mechanism of pathogen transmission is essential for the development of strategies to reduce arthropod-borne diseases. The pharmaco- and immunomodulatory properties of insect and acarine saliva play an essential role in the efficiency of pathogen transmission. The skin as the site where arthropod saliva and pathogens are inoculated - represents the key interface in vector-borne diseases. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.12.005DOI Listing
February 2019
1 Read

Prevalence of in Ticks from the Ternopil Region in Ukraine.

J Vet Res 2018 Sep 10;62(3):275-280. Epub 2018 Dec 10.

I. Horbachevsky Ternopil State Medical University, 46000 Ternopil, Ukraine.

Introduction: Lyme borreliosis/Lyme disease is caused by and is one of the most common vector-borne diseases transmitted by ticks.

Material And Methods: A total of 136 ticks, collected in the Ternopil (Ukraine) region, including 126 adults (70 females and 56 males), and 10 nymphs were examined. The identification of the species and their developmental form was based on morphological characteristics. Read More

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http://content.sciendo.com/view/journals/jvetres/62/3/articl
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http://dx.doi.org/10.2478/jvetres-2018-0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296004PMC
September 2018
14 Reads

Epidemiology of Lyme disease among US Veterans in Long Island, New York.

Ticks Tick Borne Dis 2019 02 14;10(2):407-411. Epub 2018 Dec 14.

Stony Brook University School of Medicine, Stony Brook, NY, 11794, USA; Suffolk County Chief of Arthropod-Borne Disease Laboratory, Suffolk County Department of Health Services, Yaphank, NY, 11980, USA.

In North America, Lyme disease (LD) is caused predominantly by the spirochete Borrelia burgdorferisensu stricto, and is transmitted by blacklegged ticks. Long Island, New York, is highly endemic for the disease. The C6 peptide (C6P) is currently used as a screening test for LD in our institution. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.12.003DOI Listing
February 2019
8 Reads

Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ-mediated complement evasion to promote systemic infection in vertebrate hosts.

Cell Microbiol 2019 Feb 7;21(2):e12998. Epub 2019 Jan 7.

Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.

Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. The spirochetes are transmitted from mammalian and avian reservoir hosts to humans via ticks. Following tick bites, spirochetes colonize the host skin and then disseminate haematogenously to various organs, a process that requires this pathogen to evade host complement, an innate immune defence system. Read More

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http://doi.wiley.com/10.1111/cmi.12998
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http://dx.doi.org/10.1111/cmi.12998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336514PMC
February 2019
14 Reads

Leber's hereditary optic neuropathy misdiagnosed as optic neuritis and Lyme disease in a patient with multiple sclerosis.

Authors:
Melinda Chang

BMJ Case Rep 2018 Dec 7;11(1). Epub 2018 Dec 7.

Ophthalmology, UC Davis, Sacramento, California, USA.

A 28-year-old Caucasian man developed sudden painless vision loss in the right eye. He was diagnosed with optic neuritis. MRI showed white matter lesions consistent with multiple sclerosis (MS), but no optic nerve enhancement. Read More

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http://dx.doi.org/10.1136/bcr-2018-227109DOI Listing
December 2018
28 Reads

Interventions to Improve Medication Adherence: A Review.

JAMA 2018 12;320(23):2461-2473

Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora.

Importance: Among adults with chronic illness, 30% to 50% of medications are not taken as prescribed. In the United States, it is estimated that medication nonadherence is associated with 125 000 deaths, 10% of hospitalizations, and $100 billion in health care services annually.

Observations: PubMed was searched from January 1, 2000, to September 6, 2018, for English-language randomized clinical trials of interventions to improve medication adherence. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.19271DOI Listing
December 2018
47 Reads

Controversies About Lyme Disease-Reply.

JAMA 2018 12;320(23):2482-2483

Division of Infectious Diseases, New York Medical College, Valhalla.

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http://dx.doi.org/10.1001/jama.2018.17207DOI Listing
December 2018
1 Read

Lyme Disease-An Unusual Cause of a Mitral Valve Endocarditis.

Mayo Clin Proc Innov Qual Outcomes 2018 Dec 25;2(4):398-401. Epub 2018 Oct 25.

Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN.

Lyme disease is a tick-borne infection caused by . Cardiac manifestations are rare, occurring in 0.5% to 10% of patients. Read More

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http://dx.doi.org/10.1016/j.mayocpiqo.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260468PMC
December 2018
2 Reads

p47 licenses activation of the immune deficiency pathway in the tick .

Proc Natl Acad Sci U S A 2019 01 17;116(1):205-210. Epub 2018 Dec 17.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201

The E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) acts as a molecular rheostat for the immune deficiency (IMD) pathway of the tick How XIAP activates the IMD pathway in response to microbial infection remains ill defined. Here, we identified the XIAP enzymatic substrate p47 as a positive regulator of the IMD network. XIAP polyubiquitylates p47 in a lysine 63-dependent manner and interacts with the p47 ubiquitin-like (UBX) module. Read More

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http://dx.doi.org/10.1073/pnas.1808905116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320499PMC
January 2019
2 Reads

Borrelia burgdorferi sensu lato infection in patients with peripheral facial palsy.

Ticks Tick Borne Dis 2019 02 6;10(2):398-406. Epub 2018 Dec 6.

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.

The aims of the study were to determine the frequency of borrelial infection in patients with peripheral facial palsy (PFP) and to compare clinical and laboratory characteristics of patients with borrelial PFP and patients with PFP of unknown etiology. Adult patients with PFP who presented at our department between January 2006 and December 2013 qualified for the study if they had undergone lumbar puncture and also been tested for the presence of borrelial IgM and IgG antibodies in serum and cerebrospinal fluid (CSF) in indirect chemiluminescence immunoassay. Patients with PFP who had obvious signs/symptoms indicating a disease other than Lyme borreliosis (LB) were excluded. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.019DOI Listing
February 2019
12 Reads

Host-specific expression of Ixodes scapularis salivary genes.

Ticks Tick Borne Dis 2019 02 3;10(2):386-397. Epub 2018 Dec 3.

Section of Infectious Diseases, New Haven, CT, 06520, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA.

Ixodes scapularis vectors several pathogens including Borrelia burgdorferi, the agent of Lyme disease. Nymphal and larval stages, and the pathogens transmitted by I. scapularis are maintained in a zoonotic cycle involving rodent reservoir hosts, predominantly Peromyscus leucopus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183028
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http://dx.doi.org/10.1016/j.ttbdis.2018.12.001DOI Listing
February 2019
16 Reads

Lyme Neuroborreliosis: Clinical Outcomes, Controversy, Pathogenesis, and Polymicrobial Infections.

Ann Neurol 2019 Jan;85(1):21-31

Departments of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, NY.

Lyme borreliosis is the object of numerous misconceptions. In this review, we revisit the fundamental manifestations of neuroborreliosis (meningitis, cranial neuritis, and radiculoneuritis), as these have withstood the test of time. We also discuss other manifestations that are less frequent. Read More

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http://dx.doi.org/10.1002/ana.25389DOI Listing
January 2019
4 Reads

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.

Clin Cosmet Investig Dermatol 2018 9;11:561-569. Epub 2018 Nov 9.

IGeneX Laboratories, Palo Alto, CA, USA.

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. Read More

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http://dx.doi.org/10.2147/CCID.S184521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233863PMC
November 2018
22 Reads

Regional prevalences of Borrelia burgdorferi, Borrelia bissettiae, and Bartonella henselae in Ixodes affinis, Ixodes pacificus and Ixodes scapularis in the USA.

Ticks Tick Borne Dis 2019 02 27;10(2):360-364. Epub 2018 Nov 27.

Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University (NCSU), 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:

The objective of this work was to determine the prevalence of Borrelia and Bartonella species in Ixodes spp. ticks collected from 16 USA states. Genus PCR amplification and sequence analysis of Bartonella and Borrelia 16SsRNA-23SsRNA intergenic regions were performed on DNA extracted from 929 questing adult ticks (671 Ixodes scapularis, 155 Ixodes affinis, and 103 Ixodes pacificus). Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.015DOI Listing
February 2019
1 Read

Comparative Evaluation of 2 In-Clinic Assays for Vector-Borne Disease Testing in Dogs.

Top Companion Anim Med 2018 Dec 13;33(4):114-118. Epub 2018 Sep 13.

Assay R&D, IDEXX Laboratories Inc, Westbrook, ME, USA. Electronic address:

Vector-borne agents comprise medically important infections affecting dogs throughout much of the world. Sensitive detection of antibodies directed at tick-borne disease-causing organisms in dogs is diagnostically important for veterinarians, pets and their owners, and epidemiologically important for public health surveillance. The SNAP 4Dx Plus Test (IDEXX Laboratories, Inc. Read More

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http://dx.doi.org/10.1053/j.tcam.2018.09.003DOI Listing
December 2018
6 Reads

An updated meta-analysis of the distribution and prevalence of Borrelia burgdorferi s.l. in ticks in Europe.

Int J Health Geogr 2018 12 4;17(1):41. Epub 2018 Dec 4.

Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.

Background: The bacteria of the group Borrelia burgdorferi s.l. are the etiological agents of Lyme borreliosis in humans, transmitted by bites of ticks. Read More

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https://ij-healthgeographics.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12942-018-0163-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319795PMC
December 2018
17 Reads

Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis.

J Vet Intern Med 2019 Jan 3;33(1):23-36. Epub 2018 Dec 3.

Research and Scholarship Team, McLaughlin Library, University of Guelph, Guelph, Ontario, Canada.

Background: Lyme borreliosis, a tick-borne disease, is endemic to some parts of North America and is an emerging disease in other parts of the world. Vaccination is an increasingly common, although controversial, method used in the prevention of Lyme disease in dogs; the reported efficacies of Borrelia burgdorferi vaccines in dogs are highly variable, ranging from 50% to 100%.

Objectives: To determine the efficacy of vaccines for prevention of Lyme disease in dogs in North America. Read More

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http://dx.doi.org/10.1111/jvim.15344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335541PMC
January 2019
3 Reads

Repeated cross-sectional study of Trypanosoma cruzi in shelter dogs in Texas, in the context of Dirofilaria immitis and tick-borne pathogen prevalence.

J Vet Intern Med 2019 Jan 29;33(1):158-166. Epub 2018 Nov 29.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: Vector-borne diseases have an adverse impact on health of dogs, and infected dogs can be sentinels for human infection. Infection with Trypanosoma cruzi, an agent of Chagas disease, causes fatal heart disease in dogs across the southern United States but has been neglected from wide-scale prevalence studies.

Objectives: To determine the prevalence of exposure to T. Read More

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http://dx.doi.org/10.1111/jvim.15352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335532PMC
January 2019
20 Reads

DksA Controls the Response of the Lyme Disease Spirochete to Starvation.

J Bacteriol 2019 Feb 28;201(4). Epub 2019 Jan 28.

Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, USA

The pathogenic spirochete senses and responds to changes in the environment, including changes in nutrient availability, throughout its enzootic cycle in ticks and vertebrate hosts. This study examined the role of DnaK suppressor protein (DksA) in the transcriptional response of to starvation. Wild-type and mutant strains were subjected to starvation by shifting cultures grown in rich complete medium, Barbour-Stoenner-Kelly II (BSK II) medium, to a defined mammalian tissue culture medium, RPMI 1640, for 6 h under microaerobic conditions (5% CO, 3% O). Read More

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http://jb.asm.org/lookup/doi/10.1128/JB.00582-18
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http://dx.doi.org/10.1128/JB.00582-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351744PMC
February 2019
15 Reads

Letter to the editor on "Suspicious Index in Lyme Carditis (SILC): Systematic review and proposed new risk score".

Clin Cardiol 2018 12 5;41(12):1617-1618. Epub 2018 Dec 5.

Clinical Research Scientist and Consultant, ScientificWriting Corp, Houston, Texas.

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http://dx.doi.org/10.1002/clc.23122DOI Listing
December 2018
4 Reads

Suspicious index in Lyme carditis: Construction of a new risk model in the absence of guidelines.

Clin Cardiol 2018 12 5;41(12):1619. Epub 2018 Dec 5.

Division of Cardiology, Kingston Health Science Centre, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1002/clc.23121DOI Listing
December 2018
5 Reads

Risk factors associated with the carriage of Ixodes scapularis relative to other tick species in a population of pet dogs from southeastern Ontario, Canada.

Ticks Tick Borne Dis 2019 02 17;10(2):290-298. Epub 2018 Oct 17.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2WI, Canada; Canadian Wildlife Health Cooperative, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2WI, Canada. Electronic address:

In eastern North America, the blacklegged tick, Ixodes scapularis, is the vector for Borrelia burgdorferi sensu stricto and Anaplasma phagocytophilum, the causal agents for human and canine Lyme disease and anaplasmosis, respectively. The extensive range expansion of I. scapularis in Ontario is a growing veterinary and public health concern. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.10.004DOI Listing
February 2019
7 Reads