10,798 results match your criteria Tick-Borne Diseases Lyme


Detection of municipalities at-risk of Lyme disease using passive surveillance of Ixodes scapularis as an early signal: A province-specific indicator in Canada.

PLoS One 2019 19;14(2):e0212637. Epub 2019 Feb 19.

Policy Integration and Zoonoses Division, Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, Québec, Canada.

Lyme disease, the most commonly reported vector-borne disease in North America, is caused by the spirochete Borrelia burgdorferi sensu stricto, which is transmitted by Ixodes scapularis in eastern Canada and Ixodes pacificus in western Canada. Recently, the northward range expansion of I. scapularis ticks, in south-eastern Canada, has resulted in a dramatic increase in the incidence of human Lyme disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212637PLOS
February 2019
1 Read

Association of small fiber neuropathy and post treatment Lyme disease syndrome.

PLoS One 2019 12;14(2):e0212222. Epub 2019 Feb 12.

Dean Center for Tick Borne Illness, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

Objectives: To examine whether post-treatment Lyme disease syndrome (PTLDS) defined by fatigue, cognitive complaints and widespread pain following the treatment of Lyme disease is associated with small fiber neuropathy (SFN) manifesting as autonomic and sensory dysfunction.

Methods: This single center, retrospective study evaluated subjects with PTLDS. Skin biopsies for assessment of epidermal nerve fiber density (ENFD), sweat gland nerve fiber density (SGNFD) and functional autonomic testing (deep breathing, Valsalva maneuver and tilt test) were performed to assess SFN, severity of dysautonomia and cerebral blood flow abnormalities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212222PLOS
February 2019
1 Read

Human Tick-Borne Diseases in Australia.

Front Cell Infect Microbiol 2019 28;9. Epub 2019 Jan 28.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

There are 17 human-biting ticks known in Australia. The bites of , and can cause paralysis, inflammation, and severe local and systemic reactions in humans, respectively. Six ticks, including , and may transmit , or subsp. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360175PMC
January 2019
1 Read

Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs.

Transbound Emerg Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Tick-borne diseases (TBD), caused by borrelial, rickettsial, and babesial pathogens, are common across the United States and can cause severe clinical disease in susceptible hosts, such as domestic dogs. However, there are limited TBD molecular epidemiological reports for dogs in Texas, and none for the non-Lyme borrelial pathogen responsible for causing tick-borne relapsing fever (TBRF). Therefore, data to support the prevalence of TBRF in the canine population is inadequate. Read More

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http://doi.wiley.com/10.1111/tbed.13145
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http://dx.doi.org/10.1111/tbed.13145DOI Listing
February 2019
9 Reads

Ticks and tick-borne diseases.

Med Mal Infect 2019 Feb 5. Epub 2019 Feb 5.

Service des maladies infectieuses et tropicales, Hôpitaux Universitaires de Strasbourg, Fédération de Médecine translationnelle de Strasbourg, Membre du groupe ESGBOR de l'ESCMID, 67000 Strasbourg, France.

Ticks are a major group of arthropod vectors, characterized by the diversity of pathogens they transmit, by their impact on human and animal health, and by their socioeconomic implication especially in countries of the Southern Hemisphere. In Europe, Ixodes is the most important tick due to its wide distribution in the ecosystems and the variety of transmitted pathogens, in particular Borrelia (responsible for Lyme borreliosis), but also the tick-borne encephalitis virus. Their increased presence in the environment since the beginning of the 20th century is undeniable, because of major modifications in the biodiversity caused by humans. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.007DOI Listing
February 2019

Nymphal Ixodes scapularis questing behavior explains geographic variation in Lyme borreliosis risk in the eastern United States.

Ticks Tick Borne Dis 2019 Jan 19. Epub 2019 Jan 19.

Center for Wildlife Health, University of Tennessee Institute of Agriculture, Knoxville, TN, 37996, USA. Electronic address:

Most people who contract Lyme borreliosis in the eastern United States (US) acquire infection from the bite of the nymphal life stage of the vector tick Ixodes scapularis, which is present in all eastern states. Yet <5% of Lyme borreliosis cases are reported from outside the north-central and northeastern US. Geographical differences in nymphal questing (i. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.01.001DOI Listing
January 2019
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Prevalence of Borrelia burgdorferi, Anaplasma spp., Ehrlichia spp. and Dirofilaria immitis in Canadian dogs, 2008 to 2015: a repeat cross-sectional study.

Parasit Vectors 2019 Jan 28;12(1):64. Epub 2019 Jan 28.

University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Background: Vector-borne pathogens are emerging concerns in multiple regions of Canada. Determining regional prevalence of canine vector-borne pathogens and documenting change will improve clinician awareness, enable targeted prevention, enhance diagnosis and ideally reduce the risk of disease. Study objectives were to: (i) estimate the prevalence of positive canine vector-borne test results from samples submitted in Canada; (ii) assess change in prevalence over time, from baseline (2008) to 2015; and (iii) estimate the prevalence of pathogen co-infections. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350403PMC
January 2019
5 Reads

Lyme Disease Emergence after Invasion of the Blacklegged Tick, Ixodes scapularis, Ontario, Canada, 2010-2016.

Emerg Infect Dis 2019 Feb;25(2):328-332

Analysis of surveillance data for 2010-2016 in eastern Ontario, Canada, demonstrates the rapid northward spread of Ixodes scapularis ticks and Borrelia burgdorferi, followed by increasing human Lyme disease incidence. Most spread occurred during 2011-2013. Continued monitoring is essential to identify emerging risk areas in this region. Read More

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http://dx.doi.org/10.3201/eid2502.180771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346472PMC
February 2019
5 Reads

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea.

Korean J Parasitol 2018 Dec 31;56(6):609-613. Epub 2018 Dec 31.

Department of Internal Medicine, Inha University School of Medicine, Incheon 22212, Korea.

Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.6.609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327201PMC
December 2018
5 Reads

Comparison of the epidemiological patterns of Lyme borreliosis and tick-borne encephalitis in the Czech Republic in 2007-2016.

Epidemiol Mikrobiol Imunol 2018 ;67(3):134-140

Background: Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are two vector-borne diseases transmitted by ticks. Both diseases are endemic and have been reported in all regions of the Czech Republic including urban agglomerations, but in varying proportions. Because of the natural conditions in the border areas, the risk of infection is also high for travelers from the neighboring countries such as Austria, Germany, Poland, and Slovakia. Read More

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January 2018
2 Reads

Dissociating effect of salivary gland extract from Ixodes ricinus on human fibroblasts: Potential impact on Borrelia transmission.

Ticks Tick Borne Dis 2019 02 23;10(2):433-441. Epub 2018 Dec 23.

EA7290, Virulence bactérienne précoce, groupe Borréliose de Lyme, Facultés de médecine et de pharmacie, Université de Strasbourg, France. Electronic address:

Understanding the mechanism of pathogen transmission is essential for the development of strategies to reduce arthropod-borne diseases. The pharmaco- and immunomodulatory properties of insect and acarine saliva play an essential role in the efficiency of pathogen transmission. The skin as the site where arthropod saliva and pathogens are inoculated - represents the key interface in vector-borne diseases. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.12.005DOI Listing
February 2019

Prevalence of in Ticks from the Ternopil Region in Ukraine.

J Vet Res 2018 Sep 10;62(3):275-280. Epub 2018 Dec 10.

I. Horbachevsky Ternopil State Medical University, 46000 Ternopil, Ukraine.

Introduction: Lyme borreliosis/Lyme disease is caused by and is one of the most common vector-borne diseases transmitted by ticks.

Material And Methods: A total of 136 ticks, collected in the Ternopil (Ukraine) region, including 126 adults (70 females and 56 males), and 10 nymphs were examined. The identification of the species and their developmental form was based on morphological characteristics. Read More

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http://content.sciendo.com/view/journals/jvetres/62/3/articl
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http://dx.doi.org/10.2478/jvetres-2018-0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296004PMC
September 2018
7 Reads

Epidemiology of Lyme disease among US Veterans in Long Island, New York.

Ticks Tick Borne Dis 2019 02 14;10(2):407-411. Epub 2018 Dec 14.

Stony Brook University School of Medicine, Stony Brook, NY, 11794, USA; Suffolk County Chief of Arthropod-Borne Disease Laboratory, Suffolk County Department of Health Services, Yaphank, NY, 11980, USA.

In North America, Lyme disease (LD) is caused predominantly by the spirochete Borrelia burgdorferisensu stricto, and is transmitted by blacklegged ticks. Long Island, New York, is highly endemic for the disease. The C6 peptide (C6P) is currently used as a screening test for LD in our institution. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.12.003DOI Listing
February 2019
1 Read

Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ-mediated complement evasion to promote systemic infection in vertebrate hosts.

Cell Microbiol 2019 Feb 7;21(2):e12998. Epub 2019 Jan 7.

Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.

Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. The spirochetes are transmitted from mammalian and avian reservoir hosts to humans via ticks. Following tick bites, spirochetes colonize the host skin and then disseminate haematogenously to various organs, a process that requires this pathogen to evade host complement, an innate immune defence system. Read More

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http://doi.wiley.com/10.1111/cmi.12998
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http://dx.doi.org/10.1111/cmi.12998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336514PMC
February 2019
10 Reads

Interventions to Improve Medication Adherence: A Review.

JAMA 2018 12;320(23):2461-2473

Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora.

Importance: Among adults with chronic illness, 30% to 50% of medications are not taken as prescribed. In the United States, it is estimated that medication nonadherence is associated with 125 000 deaths, 10% of hospitalizations, and $100 billion in health care services annually.

Observations: PubMed was searched from January 1, 2000, to September 6, 2018, for English-language randomized clinical trials of interventions to improve medication adherence. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.19271DOI Listing
December 2018
27 Reads

Controversies About Lyme Disease-Reply.

JAMA 2018 12;320(23):2482-2483

Division of Infectious Diseases, New York Medical College, Valhalla.

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http://dx.doi.org/10.1001/jama.2018.17207DOI Listing
December 2018
1 Read

Lyme Disease-An Unusual Cause of a Mitral Valve Endocarditis.

Mayo Clin Proc Innov Qual Outcomes 2018 Dec 25;2(4):398-401. Epub 2018 Oct 25.

Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN.

Lyme disease is a tick-borne infection caused by . Cardiac manifestations are rare, occurring in 0.5% to 10% of patients. Read More

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http://dx.doi.org/10.1016/j.mayocpiqo.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260468PMC
December 2018
1 Read

p47 licenses activation of the immune deficiency pathway in the tick .

Proc Natl Acad Sci U S A 2019 01 17;116(1):205-210. Epub 2018 Dec 17.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201

The E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) acts as a molecular rheostat for the immune deficiency (IMD) pathway of the tick How XIAP activates the IMD pathway in response to microbial infection remains ill defined. Here, we identified the XIAP enzymatic substrate p47 as a positive regulator of the IMD network. XIAP polyubiquitylates p47 in a lysine 63-dependent manner and interacts with the p47 ubiquitin-like (UBX) module. Read More

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http://dx.doi.org/10.1073/pnas.1808905116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320499PMC
January 2019
1 Read

Borrelia burgdorferi sensu lato infection in patients with peripheral facial palsy.

Ticks Tick Borne Dis 2019 02 6;10(2):398-406. Epub 2018 Dec 6.

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.

The aims of the study were to determine the frequency of borrelial infection in patients with peripheral facial palsy (PFP) and to compare clinical and laboratory characteristics of patients with borrelial PFP and patients with PFP of unknown etiology. Adult patients with PFP who presented at our department between January 2006 and December 2013 qualified for the study if they had undergone lumbar puncture and also been tested for the presence of borrelial IgM and IgG antibodies in serum and cerebrospinal fluid (CSF) in indirect chemiluminescence immunoassay. Patients with PFP who had obvious signs/symptoms indicating a disease other than Lyme borreliosis (LB) were excluded. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.019DOI Listing
February 2019
3 Reads

Host-specific expression of Ixodes scapularis salivary genes.

Ticks Tick Borne Dis 2019 02 3;10(2):386-397. Epub 2018 Dec 3.

Section of Infectious Diseases, New Haven, CT, 06520, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA.

Ixodes scapularis vectors several pathogens including Borrelia burgdorferi, the agent of Lyme disease. Nymphal and larval stages, and the pathogens transmitted by I. scapularis are maintained in a zoonotic cycle involving rodent reservoir hosts, predominantly Peromyscus leucopus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183028
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http://dx.doi.org/10.1016/j.ttbdis.2018.12.001DOI Listing
February 2019
10 Reads

Lyme Neuroborreliosis: Clinical Outcomes, Controversy, Pathogenesis, and Polymicrobial Infections.

Ann Neurol 2019 Jan;85(1):21-31

Departments of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, NY.

Lyme borreliosis is the object of numerous misconceptions. In this review, we revisit the fundamental manifestations of neuroborreliosis (meningitis, cranial neuritis, and radiculoneuritis), as these have withstood the test of time. We also discuss other manifestations that are less frequent. Read More

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http://dx.doi.org/10.1002/ana.25389DOI Listing
January 2019
2 Reads

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.

Clin Cosmet Investig Dermatol 2018 9;11:561-569. Epub 2018 Nov 9.

IGeneX Laboratories, Palo Alto, CA, USA.

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. Read More

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http://dx.doi.org/10.2147/CCID.S184521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233863PMC
November 2018
17 Reads

Comparative Evaluation of 2 In-Clinic Assays for Vector-Borne Disease Testing in Dogs.

Top Companion Anim Med 2018 Dec 13;33(4):114-118. Epub 2018 Sep 13.

Assay R&D, IDEXX Laboratories Inc, Westbrook, ME, USA. Electronic address:

Vector-borne agents comprise medically important infections affecting dogs throughout much of the world. Sensitive detection of antibodies directed at tick-borne disease-causing organisms in dogs is diagnostically important for veterinarians, pets and their owners, and epidemiologically important for public health surveillance. The SNAP 4Dx Plus Test (IDEXX Laboratories, Inc. Read More

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http://dx.doi.org/10.1053/j.tcam.2018.09.003DOI Listing
December 2018
5 Reads

Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis.

J Vet Intern Med 2019 Jan 3;33(1):23-36. Epub 2018 Dec 3.

Research and Scholarship Team, McLaughlin Library, University of Guelph, Guelph, Ontario, Canada.

Background: Lyme borreliosis, a tick-borne disease, is endemic to some parts of North America and is an emerging disease in other parts of the world. Vaccination is an increasingly common, although controversial, method used in the prevention of Lyme disease in dogs; the reported efficacies of Borrelia burgdorferi vaccines in dogs are highly variable, ranging from 50% to 100%.

Objectives: To determine the efficacy of vaccines for prevention of Lyme disease in dogs in North America. Read More

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http://dx.doi.org/10.1111/jvim.15344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335541PMC
January 2019
2 Reads

Repeated cross-sectional study of Trypanosoma cruzi in shelter dogs in Texas, in the context of Dirofilaria immitis and tick-borne pathogen prevalence.

J Vet Intern Med 2019 Jan 29;33(1):158-166. Epub 2018 Nov 29.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: Vector-borne diseases have an adverse impact on health of dogs, and infected dogs can be sentinels for human infection. Infection with Trypanosoma cruzi, an agent of Chagas disease, causes fatal heart disease in dogs across the southern United States but has been neglected from wide-scale prevalence studies.

Objectives: To determine the prevalence of exposure to T. Read More

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http://dx.doi.org/10.1111/jvim.15352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335532PMC
January 2019
8 Reads

DksA Controls the Response of the Lyme Disease Spirochete to Starvation.

J Bacteriol 2019 Feb 28;201(4). Epub 2019 Jan 28.

Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, USA

The pathogenic spirochete senses and responds to changes in the environment, including changes in nutrient availability, throughout its enzootic cycle in ticks and vertebrate hosts. This study examined the role of DnaK suppressor protein (DksA) in the transcriptional response of to starvation. Wild-type and mutant strains were subjected to starvation by shifting cultures grown in rich complete medium, Barbour-Stoenner-Kelly II (BSK II) medium, to a defined mammalian tissue culture medium, RPMI 1640, for 6 h under microaerobic conditions (5% CO, 3% O). Read More

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http://jb.asm.org/lookup/doi/10.1128/JB.00582-18
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http://dx.doi.org/10.1128/JB.00582-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351744PMC
February 2019
10 Reads

Letter to the editor on "Suspicious Index in Lyme Carditis (SILC): Systematic review and proposed new risk score".

Clin Cardiol 2018 12 5;41(12):1617-1618. Epub 2018 Dec 5.

Clinical Research Scientist and Consultant, ScientificWriting Corp, Houston, Texas.

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http://dx.doi.org/10.1002/clc.23122DOI Listing
December 2018
3 Reads

Suspicious index in Lyme carditis: Construction of a new risk model in the absence of guidelines.

Clin Cardiol 2018 12 5;41(12):1619. Epub 2018 Dec 5.

Division of Cardiology, Kingston Health Science Centre, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1002/clc.23121DOI Listing
December 2018
4 Reads

Passage of Borrelia burgdorferi through diverse Ixodid hard ticks causes distinct diseases: Lyme borreliosis and Baggio-Yoshinari syndrome.

Clinics (Sao Paulo) 2018 Nov 14;73:e394. Epub 2018 Nov 14.

Reumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Baggio-Yoshinari syndrome is an emerging, tick-borne, infectious disease recently discovered in Brazil. This syndrome is similar to Lyme disease, which is common in the United States of America, Europe and Asia; however, Brazilian borreliosis diverges from the disease observed in the Northern Hemisphere in its epidemiological, microbiological, laboratory and clinical characteristics. Polymerase chain reaction procedures showed that Baggio-Yoshinari syndrome is caused by the Borrelia burgdorferi sensu stricto spirochete. Read More

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http://dx.doi.org/10.6061/clinics/2018/e394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218955PMC
November 2018
13 Reads

Role of mustelids in the life-cycle of ixodid ticks and transmission cycles of four tick-borne pathogens.

Parasit Vectors 2018 Nov 20;11(1):600. Epub 2018 Nov 20.

Centre for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Background: Elucidating which wildlife species significantly contribute to the maintenance of Ixodes ricinus populations and the enzootic cycles of the pathogens they transmit is imperative in understanding the driving forces behind the emergence of tick-borne diseases. Here, we aimed to quantify the relative contribution of four mustelid species in the life-cycles of I. ricinus and Borrelia burgdorferi (sensu lato) in forested areas and to investigate their role in the transmission of other tick-borne pathogens. Read More

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http://dx.doi.org/10.1186/s13071-018-3126-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245527PMC
November 2018
2 Reads

Clinical spectrum of Lyme disease.

Eur J Clin Microbiol Infect Dis 2019 Feb 19;38(2):201-208. Epub 2018 Nov 19.

University Hospital "Dr. Jose Eleuterio Gonzalez", Department of Dermatology, Universidad Autonoma de Nuevo Leon, Av. Madero y Gonzalitos s/n, Colonia Mitras Centro, 64460, Monterrey, NL, Mexico.

Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. Read More

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http://link.springer.com/10.1007/s10096-018-3417-1
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http://dx.doi.org/10.1007/s10096-018-3417-1DOI Listing
February 2019
13 Reads

Can Google Trends data improve forecasting of Lyme disease incidence?

Zoonoses Public Health 2019 02 16;66(1):101-107. Epub 2018 Nov 16.

Department of Neurology and Stroke, Neurology Clinics, Eberhard Karls University, Tübingen, Germany.

Background: Online activity-based epidemiological surveillance and forecasting is getting more and more attention. To date, Google search volumes have not been assessed for forecasting of tick-borne diseases. Thus, we performed an analysis of forecasting of the Lyme disease incidence based on the traditional data extended with Google Trends. Read More

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http://doi.wiley.com/10.1111/zph.12539
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http://dx.doi.org/10.1111/zph.12539DOI Listing
February 2019
9 Reads

High burdens of Ixodes scapularis larval ticks on white-tailed deer may limit Lyme disease risk in a low biodiversity setting.

Ticks Tick Borne Dis 2019 02 3;10(2):258-268. Epub 2018 Nov 3.

Department of Ecology, Evolution, and Environmental Biology, Columbia University, 1200 Amsterdam Ave., 10027 New York, NY, United States. Electronic address:

An inverse relationship between biodiversity and human health has been termed the 'dilution effect' paradigm. In the case of tick-borne infections such as Lyme disease, the key assumption is that Borrelia burgdorferi sensu lato abundance is increased by the loss of less competent (dilution) hosts as biodiversity declines. White-tailed deer play a dual role in the pathogen cycle, as key reproductive hosts for adult ticks and incompetent hosts for the pathogen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183029
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http://dx.doi.org/10.1016/j.ttbdis.2018.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377166PMC
February 2019
10 Reads

Characterization of tick organic anion transporting polypeptides (OATPs) upon bacterial and viral infections.

Parasit Vectors 2018 Nov 14;11(1):593. Epub 2018 Nov 14.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.

Background: Ixodes scapularis organic anion transporting polypeptides (OATPs) play important roles in tick-rickettsial pathogen interactions. In this report, we characterized the role of these conserved molecules in ticks infected with either Lyme disease agent Borrelia burgdorferi or tick-borne Langat virus (LGTV), a pathogen closely related to tick-borne encephalitis virus (TBEV).

Results: Quantitative real-time polymerase chain reaction analysis revealed no significant changes in oatps gene expression upon infection with B. Read More

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http://dx.doi.org/10.1186/s13071-018-3160-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236954PMC
November 2018
2 Reads
3.430 Impact Factor

Extensive Distribution of the Lyme Disease Bacterium, Sensu Lato, in Multiple Tick Species Parasitizing Avian and Mammalian Hosts across Canada.

Healthcare (Basel) 2018 Nov 12;6(4). Epub 2018 Nov 12.

Department of Biology, Georgia Southern University, Statesboro, GA 30458, USA.

Lyme disease, caused by the spirochetal bacterium, sensu lato (Bbsl), is typically transmitted by hard-bodied ticks (Acari: Ixodidae). Whenever this tick-borne zoonosis is mentioned in medical clinics and emergency rooms, it sparks a firestorm of controversy. Denial often sets in, and healthcare practitioners dismiss the fact that this pathogenic spirochetosis is present in their area. Read More

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http://dx.doi.org/10.3390/healthcare6040131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315338PMC
November 2018
2 Reads

Of Old Lyme, ticks, and new Borrelia.

Travel Med Infect Dis 2018 Nov - Dec;26:74. Epub 2018 Nov 10.

Medizinische Fakultät, Departement Klinische Forschung (DKF), Emeritus, Departement Klinische Medizin, Ksp. 1, 7.St.W, Spitalstrasse 21, 4031 Basel CH, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2018.11.004DOI Listing
January 2019
2 Reads

Seroprevalence and current infections of canine vector-borne diseases in Nicaragua.

Parasit Vectors 2018 Nov 12;11(1):585. Epub 2018 Nov 12.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hannover, Germany.

Background: Vector-borne diseases constitute a major problem for veterinary and public health, especially in tropical regions like Central America. Domestic dogs may be infected with several vector-borne pathogens of zoonotic relevance, which may also severely compromise canine health.

Methods: To assess the prevalence of canine vector-borne diseases in Nicaragua, 329 dogs from seven cities, which were presented to the veterinarian for various reasons, were included in this study. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3173-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233566PMC
November 2018
7 Reads

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn.

PLoS One 2018 12;13(11):e0207067. Epub 2018 Nov 12.

National Microbiology Laboratory, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada.

Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207067PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231644PMC
November 2018
14 Reads

Case 34-2018: A 58-Year-Old Woman with Paresthesia and Weakness of the Left Foot and Abdominal Wall.

N Engl J Med 2018 11;379(19):1862-1868

From the Departments of Neurology (H.M.R., N.V.), Radiology (H.B.H.), and Pathology (J.A.B.), Massachusetts General Hospital, and the Departments of Neurology (H.M.R., N.V.), Radiology (H.B.H.), and Pathology (J.A.B.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1810387DOI Listing
November 2018
2 Reads

Inter- and intraspecies-specific adhesion of Lyme borreliae to human keratinocytes.

Ticks Tick Borne Dis 2019 01 28;10(1):207-212. Epub 2018 Oct 28.

Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul-Ehrlich-Str. 40, D-60596, Frankfurt, Germany. Electronic address:

Spirochetes have developed sophisticated means to successfully colonize host tissues and survive in unfavorable environments. Attachment to human cells is thought to be a key step for the establishment of an infection that causes multiple clinical symptoms. Infection of host tissues largely depends on the ability of spirochetes to attach to different cell types. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183028
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http://dx.doi.org/10.1016/j.ttbdis.2018.10.006DOI Listing
January 2019
15 Reads

High seroprevalence of Babesia antibodies among Borrelia burgdorferi-infected humans in Sweden.

Ticks Tick Borne Dis 2019 01 28;10(1):186-190. Epub 2018 Oct 28.

Department of Laboratory Medicine, Lund University, Skåne University Hospital, Lund, Sweden. Electronic address:

In northern Europe, tick-borne diseases such as Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are well known. The actual incidence of Babesia infections, however, has remained elusive. In this study, the prevalence of antibodies against two Babesia spp. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.10.007DOI Listing
January 2019
2 Reads

Acrodermatitis chronica atrophicans in children: Report on two cases and review of the literature.

Ticks Tick Borne Dis 2019 01 26;10(1):180-185. Epub 2018 Oct 26.

Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia. Electronic address:

Acrodermatitis chronica atrophicans is a late manifestation of European Lyme borreliosis and is characterized by high levels of borrelial IgG antibodies, slowly expanding skin redness usually beginning on distal parts of extremities, and corresponding histologic findings. It very rarely develops in children. The main prerequisite for the diagnosis is clinical suspicion. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.10.009DOI Listing
January 2019
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Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases.

Sci Rep 2018 Oct 29;8(1):15932. Epub 2018 Oct 29.

Department of Biological and Environmental Sciences, NanoScience Center, University of Jyväskylä, Jyväskylä, Finland.

There is insufficient evidence to support screening of various tick-borne diseases (TBD) related microbes alongside Borrelia in patients suffering from TBD. To evaluate the involvement of multiple microbial immune responses in patients experiencing TBD we utilized enzyme-linked immunosorbent assay. Four hundred and thirty-two human serum samples organized into seven categories followed Centers for Disease Control and Prevention two-tier Lyme disease (LD) diagnosis guidelines and Infectious Disease Society of America guidelines for post-treatment Lyme disease syndrome. Read More

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http://www.nature.com/articles/s41598-018-34393-9
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http://dx.doi.org/10.1038/s41598-018-34393-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206025PMC
October 2018
35 Reads

Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.

Int J Parasitol 2018 Oct 24. Epub 2018 Oct 24.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:

The incidence of babesiosis, Lyme disease and other tick-borne diseases has increased steadily in Europe and North America during the last five decades. Babesia microti is transmitted by species of Ixodes, the same ticks that transmit the Lyme disease-causing spirochete, Borrelia burgdorferi. B. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.06.006DOI Listing
October 2018
2 Reads

Immunoblot reactivity at follow-up in treated patients with Lyme neuroborreliosis and healthy controls.

Ticks Tick Borne Dis 2019 01 26;10(1):166-169. Epub 2018 Sep 26.

Department of Neurology, Medical Center - University of Freiburg, Germany.

About 5-20% of the general population in endemic areas have seroprevalence for anti-borrelial antibodies. Previous studies have shown a high rate of 25-97% of persisting anti-borrelial antibodies in patients with treated Lyme neuroborreliosis (LNB) at follow-up. These studies used immunoblots with antigens from whole-cell sonicates, which could be less specific than modern recombinant antigens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183031
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http://dx.doi.org/10.1016/j.ttbdis.2018.09.011DOI Listing
January 2019
11 Reads

Using volunteered observations to map human exposure to ticks.

Sci Rep 2018 Oct 18;8(1):15435. Epub 2018 Oct 18.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe and its incidence has steadily increased over the last two decades. In the Netherlands alone, more than 20,000 citizens are affected by LB each year. Because of this, two Dutch citizen science projects were started to monitor tick bites. Read More

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http://dx.doi.org/10.1038/s41598-018-33900-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194133PMC
October 2018
13 Reads

Current Status of Tick-Borne Diseases in South Korea.

Vector Borne Zoonotic Dis 2018 Oct 17. Epub 2018 Oct 17.

1 Department of Internal Medicine and Inha University School of Medicine , Incheon, Republic of Korea.

Background: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. Read More

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http://dx.doi.org/10.1089/vbz.2018.2298DOI Listing
October 2018
4 Reads

Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters.

BMC Vet Res 2018 Oct 16;14(1):312. Epub 2018 Oct 16.

Merial Inc., Boehringer Ingelheim, Athens, GA, USA.

Background: Prevention of Lyme disease in dogs in North America depends on effective vaccination against infection by the tick vector-born spirochete Borrelia burgdorferi. Most vaccines effectively prevent spirochete transmission to dogs during tick feeding based on immunization with the outer-surface lipoprotein A (OspA) of B. burgdorferi. Read More

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http://dx.doi.org/10.1186/s12917-018-1625-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191903PMC
October 2018
6 Reads