2,854 results match your criteria Tick-Borne Diseases Ehrlichiosis


Proteome Analysis Revealed Changes in Protein Expression Patterns Caused by Mutations in .

Front Cell Infect Microbiol 2019 18;9:58. Epub 2019 Mar 18.

Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Vector-Borne Diseases, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.

The tick-borne rickettsial pathogen, , causes monocytic ehrlichiosis in people and other vertebrate hosts. Mutational analysis in genome aids in better understanding of its infection and persistence in host cells and in the development of attenuated vaccines. Our recent RNA deep sequencing study revealed that three genomic mutations caused global changes in the gene expression patterns, which in turn affect the ability of pathogen's survival in a host and the host's ability to induce protection against the pathogen. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00058
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http://dx.doi.org/10.3389/fcimb.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431617PMC
March 2019
7 Reads

Molecular evidence of and and the association of infections with hematological responses in naturally infected dogs in Kalasin, Thailand.

Vet World 2019 Jan 23;12(1):131-135. Epub 2019 Jan 23.

Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan.

Background: Tick-borne bacteria, and are well recognized as the etiology of anemia and thrombocytopenia in dogs. The clinical signs of anaplasmosis and ehrlichiosis range from asymptomatic to severe symptoms . There are insufficient studies about epidemiological surveys of these blood parasites, also the association of infections with the hematological study. Read More

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http://dx.doi.org/10.14202/vetworld.2019.131-135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431820PMC
January 2019
1 Read

Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".

Recent Pat Antiinfect Drug Discov 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat-382481. India.

Lyme's Disease (LD) is a severe rapidly growing broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdoferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in present scenario in many countries from species to species. Read More

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http://dx.doi.org/10.2174/1574891X14666190327114641DOI Listing
March 2019
1 Read

A review on the occurrence of companion vector-borne diseases in pet animals in Latin America.

Parasit Vectors 2019 Mar 28;12(1):145. Epub 2019 Mar 28.

Institute of Parasitology, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Companion vector-borne diseases (CVBDs) are an important threat for pet life, but may also have an impact on human health, due to their often zoonotic character. The importance and awareness of CVBDs continuously increased during the last years. However, information on their occurrence is often limited in several parts of the world, which are often especially affected. Read More

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http://dx.doi.org/10.1186/s13071-019-3407-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438007PMC
March 2019
1 Read

Transmission of Anaplasma phagocytophilum (Foggie, 1949) by Ixodes ricinus (Linnaeus, 1758) ticks feeding on dogs and artificial membranes.

Parasit Vectors 2019 Mar 26;12(1):136. Epub 2019 Mar 26.

Bayer Animal Health GmbH, Monheim, Germany.

Background: The interplay of speed of activity of acaricidal products and tick-borne pathogen transmission time is the major driver for disease prevention. This study aimed to investigate the time required for transmission of Anaplasma phagocytophilum by adult Ixodes ricinus ticks in vivo on dogs, and to confirm the time required for transmission observed in vivo, in vitro.

Methods: Nymphs of I. Read More

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http://dx.doi.org/10.1186/s13071-019-3396-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434881PMC
March 2019
3.430 Impact Factor

Prevalence of Borrelia burgdorferi, Anaplasma spp., Ehrlichia spp. and Dirofilaria immitis in Canadian dogs, 2008 to 2015: a repeat cross-sectional study.

Parasit Vectors 2019 Jan 28;12(1):64. Epub 2019 Jan 28.

University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Background: Vector-borne pathogens are emerging concerns in multiple regions of Canada. Determining regional prevalence of canine vector-borne pathogens and documenting change will improve clinician awareness, enable targeted prevention, enhance diagnosis and ideally reduce the risk of disease. Study objectives were to: (i) estimate the prevalence of positive canine vector-borne test results from samples submitted in Canada; (ii) assess change in prevalence over time, from baseline (2008) to 2015; and (iii) estimate the prevalence of pathogen co-infections. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350403PMC
January 2019
9 Reads

First detection of Ehrlichia minasensis in Hyalomma marginatum ticks collected from cattle in Corsica, France.

Vet Med Sci 2019 Jan 21. Epub 2019 Jan 21.

EA7310 BIOSCOPE, Laboratoire de Virologie, Université de Corse-Inserm, Corte, France.

Ehrlichiosis are severe, feverish tick-borne illnesses caused by specific species within the genus Ehrlichia (Anaplasmataceae family). Recent data suggest that ruminants in Corsica area reservoir for several Anaplasmataceae species. The purpose of our study was to determine whether Ehrlichia species could be detected in ticks collected in Corsican ruminants by using molecular methods. Read More

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http://dx.doi.org/10.1002/vms3.140DOI Listing
January 2019

PCR detection of Ehrlichia ruminantium and Babesia bigemina in cattle from Kwara State, Nigeria: unexpected absence of infection.

Parasitol Res 2019 Mar 17;118(3):1025-1029. Epub 2019 Jan 17.

Bristol Veterinary School, University of Bristol, Langford, Bristol, BS40 5DU, UK.

Ticks and tick-borne diseases (TBDs) continue to pose an insidious and ever-present threat to livestock and livelihoods across the globe. Two of the most significant TBDs of cattle in Africa are heartwater and babesioisis, caused by Ehrlichia ruminantium and Babesia bigemina respectively. Both pathogens are endemic in Nigeria. Read More

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http://dx.doi.org/10.1007/s00436-019-06204-1DOI Listing
March 2019
1 Read
2.327 Impact Factor

Molecular detection and characterization of Ehrlichia ruminantium from cattle in Mozambique.

Acta Trop 2019 Mar 9;191:198-203. Epub 2019 Jan 9.

Laboratório de Imunoparasitologia, Departamento de Patologia Veterinária, Faculdade de Ciências Agrárias e Veterinárias (FCAV), Universidade Estadual Paulista (Unesp), Jaboticabal, SP, Brazil. Electronic address:

Heartwater caused by Ehrlichia ruminantiumis a disease of domestic and wild ruminants and one of the most economically important tick-borne diseases in Africa. The present study aimed to investigate the occurrence and genetic diversity of E. ruminantium in blood samples from 210 cattle sampled in five districts of Maputo Province, Mozambique. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.007DOI Listing
March 2019
2 Reads

Molecular Detection and Phylogenetic Analysis of Anaplasma phagocytophilum in Horses in Korea.

Korean J Parasitol 2018 Dec 31;56(6):559-565. Epub 2018 Dec 31.

College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.

The identification and characterization of pathogenic and zoonotic tick-borne diseases like granulocytic anaplasmosis are essential for developing effective control programs. The differential diagnosis of pathogenic Anaplasma phagocytophilum and non-pathogenic A. phagocytophilum-like Anaplasma spp. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.6.559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327205PMC
December 2018
8 Reads

Molecular identification of Ehrlichia ewingii in a polyarthritic Texas dog.

Vet Clin Pathol 2019 Mar 9;48(1):96-99. Epub 2019 Jan 9.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas.

An 8-year-old, neutered male, Golden Retriever presented for bilateral carpal joint effusion. A complete blood count revealed mild leukopenia and marked thrombocytopenia. Samples were sent to the Texas A&M Veterinary Medical Diagnostic Laboratory for blood smear review and serologic testing for tick-borne diseases. Read More

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http://doi.wiley.com/10.1111/vcp.12690
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http://dx.doi.org/10.1111/vcp.12690DOI Listing
March 2019
18 Reads

Evidence of in Argentina through molecular detection in marsh deer ().

Int J Parasitol Parasites Wildl 2019 Apr 17;8:45-49. Epub 2018 Dec 17.

Instituto de Biotecnología, Instituto Nacional de Tecnología Agropecuaria (INTA), Las Cabañas y Los Reseros s/n (B1712WAA), Castelar, Buenos Aires, Argentina.

Vector-borne pathogens are responsible for serious emerging diseases and have been widely described in wildlife. causes the zoonotic "monocytic ehrlichiosis" in humans, is transmitted by the tick and its reservoir host is the white-tailed deer () in North America. Little is known about the native reservoir and the tick vectors involved in the transmission cycle in South America. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312859PMC
April 2019
1 Read

Low genetic diversity of Ehrlichia canis associated with high co-infection rates in Rhipicephalus sanguineus (s.l.).

Parasit Vectors 2019 Jan 7;12(1):12. Epub 2019 Jan 7.

UMR BIPAR, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94700, Maisons-Alfort, France.

Background: Rhipicephalus sanguineus sensu lato (s.l.) is the most widely distributed ixodid tick and is a vector of major canine and human pathogens. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-018-3194-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322249PMC
January 2019
18 Reads
3.430 Impact Factor

Ehrlichia ruminantium antigens and peptides induce cytotoxic T cell responses in vitro.

Vet Immunol Immunopathol 2019 Jan 19;207:1-9. Epub 2018 Nov 19.

Agricultural Research Council-Onderstepoort Veterinary Research, Private Bag X5, Onderstepoort 0110, South Africa; Department of Veterinary Tropical Diseases, Veterinary Faculty, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa.

Since CD8 T cells play an important role in resistance to infection with heartwater, effective vaccines against this disease will likely require identification of antigens that contain CD8 T cell epitopes responsible for cytotoxic T lymphocyte (CTL) responses. With the use of the fluorescent antigen-transfected target cell (FATT)-CTL assay, IFN-γ ELISPOT and flow cytometry, peptides that induce CTL, proliferation of CD8 + T cells and IFN-γ production were identified as possible target antigens for vaccine development. Of particular relevance was the finding that different peptides from different antigens were able to elicit varied cytotoxic activities by immune peripheral blood mononuclear cells (PBMC) from heartwater immune tick-infected sheep. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652427183029
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http://dx.doi.org/10.1016/j.vetimm.2018.11.012DOI Listing
January 2019
15 Reads

Molecular detection of rickettsial tick-borne agents in white-tailed deer (Odocoileus virginianus yucatanensis), mazama deer (Mazama temama), and the ticks they host in Yucatan, Mexico.

Ticks Tick Borne Dis 2019 02 27;10(2):365-370. Epub 2018 Nov 27.

Campus de Ciencias Biológicas y Agropecuarias, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Yucatán, Mexico.

Twenty-five white-tailed deer (Odocoileus virginianus yucatanensis) (WTD), 4 mazama deer (Mazama temama) (MD), and the ticks they host in Yucatan, Mexico were sampled to run a molecular survey for tick-borne rickettsial agents. The prevalence of rickettsial agents was 20% in WTD (5/25) and 50% in MD (2/4). When sequencing the nested PCR products, E. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.018DOI Listing
February 2019
1 Read

Comparative Evaluation of 2 In-Clinic Assays for Vector-Borne Disease Testing in Dogs.

Top Companion Anim Med 2018 Dec 13;33(4):114-118. Epub 2018 Sep 13.

Assay R&D, IDEXX Laboratories Inc, Westbrook, ME, USA. Electronic address:

Vector-borne agents comprise medically important infections affecting dogs throughout much of the world. Sensitive detection of antibodies directed at tick-borne disease-causing organisms in dogs is diagnostically important for veterinarians, pets and their owners, and epidemiologically important for public health surveillance. The SNAP 4Dx Plus Test (IDEXX Laboratories, Inc. Read More

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http://dx.doi.org/10.1053/j.tcam.2018.09.003DOI Listing
December 2018
6 Reads

Isolation and molecular detection of Ehrlichia species from ticks in western, central, and eastern Japan.

Ticks Tick Borne Dis 2019 02 13;10(2):344-351. Epub 2018 Nov 13.

United Graduate School of Agricultural Science and Veterinary Science, Gifu University, Gifu, Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.

Ehrlichiosis is a tick-borne bacterial disease caused by pathogens of the Ehrlichia genus. Although human ehrlichiosis has not been reported in Japan, Ehrlichia spp., which are closely related to Ehrlichia chaffeensis, were detected in several species of ixodid ticks. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.010DOI Listing
February 2019
1 Read

PCR sensitivity of peripheral blood of dogs co-infected with Leishmania spp. and Ehrlichia spp. in endemic area of Brazil.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):843-847

Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal da Grande Dourados , Dourados, MS, Brasil.

Introduction: Peripheral blood of 400 dogs infected with Leishmania and Ehrlichia were analyzed using polymerase chain reaction (PCR), and clinical signs were characterized.

Methods: PCR and parasitological tests were conducted.

Results: PCR was positive for Leishmania in 84. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0037-8682-0040-2018DOI Listing
February 2019
13 Reads

Repeated cross-sectional study of Trypanosoma cruzi in shelter dogs in Texas, in the context of Dirofilaria immitis and tick-borne pathogen prevalence.

J Vet Intern Med 2019 Jan 29;33(1):158-166. Epub 2018 Nov 29.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: Vector-borne diseases have an adverse impact on health of dogs, and infected dogs can be sentinels for human infection. Infection with Trypanosoma cruzi, an agent of Chagas disease, causes fatal heart disease in dogs across the southern United States but has been neglected from wide-scale prevalence studies.

Objectives: To determine the prevalence of exposure to T. Read More

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http://dx.doi.org/10.1111/jvim.15352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335532PMC
January 2019
19 Reads

Occupational risk for personnel working in veterinary clinics through exposure to vectors of rickettsial pathogens.

Ticks Tick Borne Dis 2019 02 31;10(2):299-304. Epub 2018 Oct 31.

Universidad Autónoma de Cd. Juárez (UACJ), Av. Plutarco Elias Calles 1210, Cd. Juárez, Chihuahua, 32310, Mexico. Electronic address:

Workers at veterinary clinics are exposed to zoonotic pathogens, which, though infrequently, can lead to serious consequences. The aim of the present study was to estimate the seroprevalence for rickettsial pathogens in veterinary clinic personnel in Ciudad Juárez, Chihuahua, Mexico. Voluntary participants included 106 veterinarians, 19 pet groomers, 36 veterinary assistants and 6 administrative workers who supplied blood samples taken by venipuncture. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.10.012DOI Listing
February 2019
14 Reads

Risk factors associated with the carriage of Ixodes scapularis relative to other tick species in a population of pet dogs from southeastern Ontario, Canada.

Ticks Tick Borne Dis 2019 02 17;10(2):290-298. Epub 2018 Oct 17.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2WI, Canada; Canadian Wildlife Health Cooperative, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2WI, Canada. Electronic address:

In eastern North America, the blacklegged tick, Ixodes scapularis, is the vector for Borrelia burgdorferi sensu stricto and Anaplasma phagocytophilum, the causal agents for human and canine Lyme disease and anaplasmosis, respectively. The extensive range expansion of I. scapularis in Ontario is a growing veterinary and public health concern. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.10.004DOI Listing
February 2019
6 Reads

Role of mustelids in the life-cycle of ixodid ticks and transmission cycles of four tick-borne pathogens.

Parasit Vectors 2018 Nov 20;11(1):600. Epub 2018 Nov 20.

Centre for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Background: Elucidating which wildlife species significantly contribute to the maintenance of Ixodes ricinus populations and the enzootic cycles of the pathogens they transmit is imperative in understanding the driving forces behind the emergence of tick-borne diseases. Here, we aimed to quantify the relative contribution of four mustelid species in the life-cycles of I. ricinus and Borrelia burgdorferi (sensu lato) in forested areas and to investigate their role in the transmission of other tick-borne pathogens. Read More

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http://dx.doi.org/10.1186/s13071-018-3126-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245527PMC
November 2018
3 Reads

Investigation of the tick-borne pathogens Rickettsia helvetica and Anaplasma phagocytophilum in the blood of the domestic goat (Capra hircus).

Authors:
A Rymaszewska

Pol J Vet Sci 2018 Jun;21(2):415-417

Department of Genetics, University of Szczecin, Felczaka 3C, 71-412 Szczecin, Poland.

The bacterial species Anaplasma phagocytophilum and Rickettsia helvetica are pathogenic for humans and domestic animals and are transmitted by ticks, e.g., of the Ixodes genus. Read More

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http://dx.doi.org/10.24425/122607DOI Listing
June 2018
1 Read

Seroprevalence and current infections of canine vector-borne diseases in Nicaragua.

Parasit Vectors 2018 Nov 12;11(1):585. Epub 2018 Nov 12.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hannover, Germany.

Background: Vector-borne diseases constitute a major problem for veterinary and public health, especially in tropical regions like Central America. Domestic dogs may be infected with several vector-borne pathogens of zoonotic relevance, which may also severely compromise canine health.

Methods: To assess the prevalence of canine vector-borne diseases in Nicaragua, 329 dogs from seven cities, which were presented to the veterinarian for various reasons, were included in this study. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3173-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233566PMC
November 2018
15 Reads

The relationship between ehrlichiosis and the development of hematologic malignancies.

Med Hypotheses 2018 Dec 14;121:57-59. Epub 2018 Sep 14.

Rush University Medical Center, Division of Hematology/Oncology and Cell Therapy, 1725 W. Harrison, Suite 809, Chicago, IL 60612, United States. Electronic address:

Viral and bacterial infections cause chronic inflammation and produce bacterial metabolites that may lead to carcinogenesis. Ehrlichiosis is an intracellular infection that primarily infects white blood cells. Given that infections can lead to cancer, and that Ehrlichia has tropism for white blood cells, it can be deduced that Ehrlichia may cause hematologic malignancies, such as acute leukemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183047
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http://dx.doi.org/10.1016/j.mehy.2018.09.026DOI Listing
December 2018
13 Reads

Seroprevalence of vector-borne pathogens in dogs from Croatia.

Parasitol Res 2019 Jan 31;118(1):347-352. Epub 2018 Oct 31.

Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Savska cesta 143, 10000, Zagreb, Croatia.

Canine vector-borne pathogens (VBPs) are a group of globally distributed and rapidly spreading microorganisms transmitted by arthropods. In the present survey, we investigated Anaplasma spp., Ehrlichia canis, Dirofilaria immitis and Borrelia burgdorferi sensu lato seroprevalence between three groups of dogs (asymptomatic, suspected and deceased) from continental and coastal regions of Croatia with the commercial point-of-care SNAP®4Dx®Plus for VBPs. Read More

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http://link.springer.com/10.1007/s00436-018-6129-7
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http://dx.doi.org/10.1007/s00436-018-6129-7DOI Listing
January 2019
4 Reads

Current Status of Tick-Borne Diseases in South Korea.

Vector Borne Zoonotic Dis 2019 Apr 17;19(4):225-233. Epub 2018 Oct 17.

1 Department of Internal Medicine and Inha University School of Medicine, Incheon, Republic of Korea.

Background: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. Read More

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http://dx.doi.org/10.1089/vbz.2018.2298DOI Listing
April 2019
10 Reads

Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology.

Onderstepoort J Vet Res 2018 Oct 9;85(1):e1-e5. Epub 2018 Oct 9.

Department of Companion Animal Clinical Studies, University of Pretoria.

Canine babesiosis and ehrlichiosis are important tick-borne infections in South Africa. Many South African general veterinary practitioners perceive co-infection with Ehrlichia spp. as a common occurrence in dogs with babesiosis. Read More

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http://dx.doi.org/10.4102/ojvr.v85i1.1626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324083PMC
October 2018
5 Reads

Epidemiology of Ehrlichia canis in healthy dogs from the Southeastern region of the state of Rio de Janeiro, Brazil.

Prev Vet Med 2018 Nov 14;159:135-142. Epub 2018 Sep 14.

Department of Epidemiology and Public Health, Veterinary Institute, Federal Rural University of Rio de Janeiro, Br 465, km 7, Seropedica, Rio de Janeiro, 23897-000, Brazil. Electronic address:

This cross-sectional, observational, and descriptive study aims to investigate the epidemiology of Ehrlichia canis in healthy owned dogs from the Southeastern region of Rio de Janeiro, Brazil. Blood samples were collected from 390 households dogs. During the visits, an epidemiological questionnaire was filled out concerning the dogs' characteristics as well as the environments in which they lived. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675877183032
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http://dx.doi.org/10.1016/j.prevetmed.2018.09.012DOI Listing
November 2018
13 Reads

Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura.

BMJ Case Rep 2018 Oct 2;2018. Epub 2018 Oct 2.

Department of Pulmonary and Critical Care Medicine, University of Louisville, Louisville, Kentucky, USA.

Ehrlichiosis is a rare tickborne illness that can manifest from an asymptomatic, self-limiting disease to a severe presentation with encephalopathy and renal failure. Ehrlichiosis is diagnosed largely based on patient history with confirmatory tests including peripheral blood smear, serology and PCR. Empiric treatment is warranted in patients with suspected tick bites as a delay in treatment can result in multiorgan failure. Read More

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http://dx.doi.org/10.1136/bcr-2018-226665DOI Listing
October 2018
9 Reads

Large-scale health disparities associated with Lyme disease and human monocytic ehrlichiosis in the United States, 2007-2013.

PLoS One 2018 27;13(9):e0204609. Epub 2018 Sep 27.

Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado, United States of America.

Promoting health equity is a fundamental public health objective, yet health disparities remain largely overlooked in studies of vectorborne diseases, especially those transmitted by ticks. We sought to identify health disparities associated with Lyme disease and human monocytic ehrlichiosis, two of the most pervasive tickborne diseases within the United States. We used general linear mixed models to measure associations between county-level disease incidence and six variables representing racial/ethnic and socioeconomic characteristics of counties (percent white non-Hispanic; percent with a bachelors degree or higher; percent living below the poverty line; percent unemployed; percent of housing units vacant; per capita number of property crimes). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204609PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160131PMC
March 2019
2 Reads

Continued expansion of tick-borne pathogens: Tick-borne encephalitis virus complex and Anaplasma phagocytophilum in Denmark.

Ticks Tick Borne Dis 2019 01 17;10(1):115-123. Epub 2018 Sep 17.

Clinical Centre for Emerging and Vector-borne Infections, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark; Department of Infectious diseases, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark. Electronic address:

Tick-borne encephalitis virus (TBEV) is a tick-transmitted flavivirus within the tick-borne encephalitis (TBE) complex. The TBE complex is represented by both TBEV and louping ill virus (LIV) in Denmark. Anaplasma phagocytophilum is also transmitted by ticks and is believed to play an essential role in facilitating and aggravating LIV infection in sheep. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.09.007DOI Listing
January 2019

Exposure to Ticks and their Pathogens in Northeast Missouri.

Authors:
Deborah A Hudman

Mo Med 2018 Jul-Aug;115(4):374-379

Deborah A. Hudman, MS, is in the Department of Microbiology/Immunology, A.T. Still University Kirksville College of Osteopathic Medicine.

While the prevalence of human pathogens has been quantified in ticks in Adair County, Missouri, the prevalence of residents acquiring tick-borne diseases and seeking medical treatment has not. A public survey (n=109) revealed that 96% of respondents reported finding attached ticks on their person; of these, 38% developed symptoms post tick bite; of these, 55% reported consultation with a health care provider. Overall, 89% of practitioners surveyed had treated at least one patient for tick-borne disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140261PMC
September 2018
6 Reads

Identification of novel immunoreactive proteins and delineation of a specific epitope of Anaplasma phagocytophilum.

Microb Pathog 2018 Dec 11;125:183-188. Epub 2018 Sep 11.

Department of Microbiology, College of Medicine, Soochow University, Suzhou, Jiangsu Province, 215123, China. Electronic address:

Human granulocytic anaplasmosis (HGA), an increasingly recognized febrile tick-borne illness, is caused by a gram-negative obligate intracellular bacterium Anaplasma phagocytophilum. Because of nonspecific clinical manifestations, diagnosis of HGA highly depends on laboratory tests. Identification of immunoreactive proteins is prerequisite for development of specific and sensitive immunoassays for HGA. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.09.017DOI Listing
December 2018
2 Reads
2.000 Impact Factor

Molecular detection and characterization of tick-borne protozoan and rickettsial pathogens isolated from cattle on Pemba Island, Tanzania.

Ticks Tick Borne Dis 2018 09 4;9(6):1437-1445. Epub 2018 Jul 4.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

Tick-borne diseases cause significant losses to livestock production in tropical and subtropical regions. In Tanzania, detailed studies on tick-borne pathogens in cattle using sensitive molecular detection methods are scarce. In this study, we investigated the occurrence of Theileria spp. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.06.014DOI Listing
September 2018
6 Reads

Tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran: A systematic review.

PLoS Negl Trop Dis 2018 09 11;12(9):e0006722. Epub 2018 Sep 11.

Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Background: Tick-borne zoonoses in the Order Rickettsiales and Legionellales cause infections that often manifest as undifferentiated fevers that are not easy to distinguish from other causes of acute febrile illnesses clinically. This is partly attributed to difficulty in laboratory confirmation since convalescent sera, specific diagnostic reagents, and the required expertise may not be readily available. As a result, a number of tick-borne zoonoses are underappreciated resulting in unnecessary morbidity, mortality and huge economic loses. Read More

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https://dx.plos.org/10.1371/journal.pntd.0006722
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http://dx.doi.org/10.1371/journal.pntd.0006722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181433PMC
September 2018
34 Reads

Some aspects on tick species in Mongolia and their potential role in the transmission of equine piroplasms, Anaplasma phagocytophilum and Borrelia burgdorferi L.

Parasitol Res 2018 Nov 3;117(11):3557-3566. Epub 2018 Sep 3.

Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210, Wien, Austria.

Ticks are cosmopolitan vectors of numerous diseases, and detection of various pathogens in ticks can help to assess their distribution. In the current study, 528 adult ticks were collected from grazing animals or the ground in ten different Mongolian provinces. Dermacentor nuttalli constituted 76. Read More

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http://dx.doi.org/10.1007/s00436-018-6053-xDOI Listing
November 2018
5 Reads

Tick-Borne Illnesses in the United States.

Prim Care 2018 Sep 9;45(3):379-391. Epub 2018 Jul 9.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA.

Close interaction with nature can lead to tick-borne illnesses, which are seen most frequently in primary care clinics when patients present symptoms. Considerable morbidity can result from untreated infections. Fortunately, these illnesses are often easily managed when diagnosed early. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00954543183004
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http://dx.doi.org/10.1016/j.pop.2018.05.011DOI Listing
September 2018
36 Reads

Ticks infesting dogs in rural communities of Yucatan, Mexico and molecular diagnosis of rickettsial infection.

Transbound Emerg Dis 2019 Jan 31;66(1):102-110. Epub 2018 Aug 31.

Facultad de Medicina Veterinaria y Zootecnia, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México.

Rickettsial infection in dog-associated ticks in three rural communities of Yucatan, Mexico was investigated using qPCR and nested PCR assays. A total of 319 dogs were studied and ticks samples were collected. A total of 170 dogs were infested with ticks (frequency of 53. Read More

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http://dx.doi.org/10.1111/tbed.12990DOI Listing
January 2019
12 Reads

Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection.

PLoS Pathog 2018 08 6;14(8):e1007234. Epub 2018 Aug 6.

Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America.

Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we sought to investigate the impact of type I IFNs on hematopoiesis in a tick-borne infection with a virulent ehrlichial pathogen that causes shock-like disease. During infection, IFNα/β induced severe bone marrow (BM) loss, blunted infection-induced emergency myelopoiesis, and reduced phenotypic HSPCs and HSCs. Read More

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https://dx.plos.org/10.1371/journal.ppat.1007234
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http://dx.doi.org/10.1371/journal.ppat.1007234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095620PMC
August 2018
8 Reads

Detection of Anaplasmataceae agents and co-infection with other tick-borne protozoa in dogs and Rhipicephalus sanguineus sensu lato ticks.

Exp Appl Acarol 2018 Aug 2;75(4):429-435. Epub 2018 Aug 2.

Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, Malaysia.

Anaplasmosis and ehrlichiosis are of serious health concern worldwide for animals and humans. In the present study, we report the occurrence of Anaplasma platys and Ehrlichia canis in dogs and Rhipicephalus sanguineus sensu lato (s.l. Read More

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http://dx.doi.org/10.1007/s10493-018-0280-9DOI Listing
August 2018
7 Reads
1.622 Impact Factor

Zoonotic Anaplasma phagocytophilum, Ehrlichia canis, Dirofilaria immitis, Borrelia burgdorferi, and spotted fever group rickettsiae (SFGR) in different types of dogs.

Parasitol Res 2018 Nov 31;117(11):3407-3412. Epub 2018 Jul 31.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Dogs can carry and share zoonotic pathogens with humans. This problem is understudied in different parts of the world, including Jordan. This study determined the prevalence of Anaplasma phagocytophilum, Ehrlichia canis, Dirofilaria immitis, and Borrelia burgdorferi using the SNAP 4Dx Plus test and spotted fever group rickettsiae (SFGR) using enzyme immunoassay IgG test in different types of dogs (farm/breeding, police, and stray) in Jordan. Read More

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http://link.springer.com/10.1007/s00436-018-6033-1
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http://dx.doi.org/10.1007/s00436-018-6033-1DOI Listing
November 2018
9 Reads

Unexpected cause of fever in a patient with untreated HIV.

BMJ Case Rep 2018 Jul 3;2018. Epub 2018 Jul 3.

Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.

We report a case of a 27-year-old man with a history of untreated HIV who presented with fever, rash and leg cramps. Initial suspicion was high for an infectious process; however, after an exhaustive evaluation, thyrotoxicosis was revealed as the aetiology of his symptoms. Recent intravenous contrast administration complicated his workup to determine the exact cause of hyperthyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2018-225087DOI Listing
July 2018
29 Reads

Serological Evidence of Borrelia burgdorferi, Anaplasma phagocytophilum and Ehrlichia Spp. Infections in Horses from Southeastern Bulgaria.

Vector Borne Zoonotic Dis 2018 11 3;18(11):588-594. Epub 2018 Jul 3.

4 Department of Infectious Diseases, Military Medical Academy , Sofia, Bulgaria .

Lyme Borreliosis and granulocytic anaplasmosis are less extensively studied in horses than in dogs and humans. Equine ehrlichiosis is not known in Europe and is in the initial stage of investigation in South, Central, and North America. The aim of this study was to determine the seroprevalence of these infections in Bulgaria. Read More

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http://dx.doi.org/10.1089/vbz.2018.2293DOI Listing
November 2018
27 Reads

Molecular survey and characterization of Theileria annulata and Ehrlichia ruminantium in cattle from Northwest China.

Parasitol Int 2018 Dec 27;67(6):679-683. Epub 2018 Jun 27.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

Theileriosis and ehrlichiosis are two important tick-borne diseases affecting cattle farming in China. However, limited information is available regarding prevalence and molecular characterization of Theileria annulata and Ehrlichia ruminantium in cattle in Xinjiang Uygur Autonomous Region (XUAR), northwestern China. In this study, a total of 176 blood samples of cattle from three rural areas of XUAR were collected in June 2017 and were tested by nested-PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835769183008
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http://dx.doi.org/10.1016/j.parint.2018.06.011DOI Listing
December 2018
10 Reads

Serological reactivity to Anaplasma phagocytophilum in neoehrlichiosis patients.

Eur J Clin Microbiol Infect Dis 2018 Sep 14;37(9):1673-1678. Epub 2018 Jun 14.

Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

The tick-borne bacterium Candidatus (Ca.) Neoehrlichia (N.) mikurensis is a cause of "fever of unknown origin" because this strict intracellular pathogen escapes detection by routine blood cultures. Read More

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http://dx.doi.org/10.1007/s10096-018-3298-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133046PMC
September 2018
4 Reads

Protein and DNA synthesis demonstrated in cell-free Ehrlichia chaffeensis organisms in axenic medium.

Sci Rep 2018 Jun 18;8(1):9293. Epub 2018 Jun 18.

Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA.

Ehrlichia chaffeensis, a tick-transmitted rickettsial bacterium, is the causative agent of human monocytic ehrlichiosis. Biochemical characterization of this and other related Rickettsiales remains a major challenge, as they require a host cell for their replication. We investigated the use of an axenic medium for E. Read More

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http://dx.doi.org/10.1038/s41598-018-27574-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006305PMC
June 2018
6 Reads

A new TaqMan method for the reliable diagnosis of Ehrlichia spp. in canine whole blood.

Parasit Vectors 2018 Jun 18;11(1):350. Epub 2018 Jun 18.

ERBA Molecular, Bartholomew's Walk, Cambridgeshire Business Park, Ely, Cambridgeshire, CB7 4EA, UK.

Background: Ehrlichiosis is an important emerging infectious disease of the canid family and humans worldwide. To date, no extensive evaluation or validation of a molecular diagnostic test for ehrlichiosis has been published. Here, we present data for a newly designed TaqMan assay and compare its performance to a commercial technology (PCRun®). Read More

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http://dx.doi.org/10.1186/s13071-018-2914-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006785PMC
June 2018
6 Reads