J Med Case Rep 2021 Sep 25;15(1):473. Epub 2021 Sep 25.
Department of Endocrinology, Diabetology and Metabolism, Toyama Prefectural Rehabilitaion Hospital and Support Center for Children with Disabilities, 36 Shimo-Iino, Toyama-shi, Toyama, 931-8517, Japan.
Background: Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone. Although Graves' disease is a common autoimmune thyroid disorder, the coexistence of these two diseases is extremely rare and makes the diagnosis and treatment complicated, leading to the delayed diagnosis of resistance to thyroid hormone. We describe the case of a Japanese man with resistance to thyroid hormone coexisting with Graves' disease, in which the correct diagnosis of resistance to thyroid hormone was delayed by masking of the signs of syndrome of inappropriate secretion of thyroid stimulating hormone, with final diagnosis 30 years after the initial treatment for Graves' disease. Read More