9,216 results match your criteria Thyrotoxicosis Imaging


Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation.

Leuk Res Rep 2019 22;11:5-7. Epub 2018 Nov 22.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, Japan.

Thyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroidism. Read More

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November 2018

UNFAVORABLE SOCIOECONOMIC FACTORS UNDERLIE HIGH RATES OF HOSPITALIZATION FOR COMPLICATED THYROTOXICOSIS IN SOME REGIONS OF THE UNITED STATES.

Thyroid 2018 Dec 7. Epub 2018 Dec 7.

Texas Tech University Health Sciences Center School of Medicine, Internal Medicine, Division of Endocrinology, Lubbock, United States ;

Objective: Our institution, a safety net, university, tertiary hospital located in West Texas has a high number of hospital admissions for complicated thyrotoxicosis. We hypothesized that unfavorable socioeconomic conditions result in increased risk of poor outcomes in hyperthyroid patients, and upshot rates of hospitalization for thyrotoxicosis in West Texas. The primary aim of our study was to identify factors associated with admission for complicated thyrotoxicosis in patients living in the Panhandle and Llano Estacado of Texas. Read More

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December 2018

A silent myocardial infarction with normal coronary arteries associated with Graves' disease.

Heart Lung 2018 Nov 28. Epub 2018 Nov 28.

Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Jiefang Road 1095, Wuhan 430030, Hubei, PR China. Electronic address:

Acute myocardial infarction (AMI) is a scarce but fatal complication in Graves' disease (GD). Silent myocardial infarction (MI) associated with GD has never been reported. A 37-year-old male patient was admitted due to poorly controlled hyperthyroidism and persistent fever. Read More

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November 2018
1 Read

Management of fetal goiters : 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays de Loire perinatal network.

J Matern Fetal Neonatal Med 2018 Dec 4:1-191. Epub 2018 Dec 4.

a Department of Gynecology and Obstetrics , CIC Hôpital Mère-Enfant , Nantes , France.

Introduction: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. Read More

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December 2018
3 Reads

A Case of Thyrotoxicosis due to Simultaneous Occurrence of Subacute Thyroiditis and Graves' Disease.

Case Rep Endocrinol 2018 30;2018:3210317. Epub 2018 Oct 30.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

Subacute thyroiditis is an inflammatory disorder of the thyroid. Graves' disease is an autoimmune thyroid disease in which thyroid hormones are overproduced. Here we present a rare case of thyrotoxicosis due to the simultaneous occurrence of both diseases. Read More

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October 2018
2 Reads

Management of thyrotoxicosis in children and adolescence: a Turkish multi-center experience.

J Clin Res Pediatr Endocrinol 2018 Nov 29. Epub 2018 Nov 29.

Gaziosmanpaşa Taksim E.A.H., Çocuk Endokrinoloji Kliniği, Istanbul, Turkey.

Objective: To determine demographic and biochemical features of childhood and juvenile thyrotoxicosis and determine the treatment outcomes in them.

Methods: We reviewed records of 503 children from in 12 different cities of Turkey who were diagnosed with thyrotoxicosis between 2007 to 2017.

Results: In all, 375 (74. Read More

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November 2018
2 Reads

[Secondary osteoporosis. Hyperthyroidism.]

Authors:
Akihiro Yasoda

Clin Calcium 2018 ;28(12):1619-1625

Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Thyrotoxicosis, commonly seen in a condition with Graves' disease, causes increased bone absorption and results in osteoporosis with increased bone turnover. The osteoporotic state is dominant in cortical bones with slight impairment of calcium-homeostasis, although the precise mechanism is still elusive. It ought to be recovered in accordance with the amelioration of thyroid hormone status, but past history of thyrotoxicosis might cause bone fragility, especially in post-menopausal or senile patients. Read More

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January 2018

Diabetic Ketoacidosis Associated with Thyroxine (T₄) Toxicosis and Thyrotoxic Cardiomyopathy.

Medicina (Kaunas) 2018 Nov 26;54(6). Epub 2018 Nov 26.

Department of Internal Medicine, Hospital Regional Lambayeque, Chiclayo, Lambayeque 14012, Peru.

Thyrotoxicosis and diabetic ketoacidosis (DKA) both may present as endocrine emergencies and may have devastating consequences if not diagnosed and managed promptly and effectively. The combination of diabetes mellitus (DM) with thyrotoxicosis is well known, and one condition usually precedes the other. Furthermore, thyrotoxicosis is complicated by some degree of cardiomyopathy in at least 5% de patients; but the coexistence of DKA, thyroxin (T₄) toxicosis, and acute cardiomyopathy is extremely rare. Read More

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November 2018
1 Read

Prolonged coma resulting from massive levothyroxine overdose and the utility of N-terminal prohormone brain natriuretic peptide (NT-proBNP).

Clin Toxicol (Phila) 2018 Nov 28:1-3. Epub 2018 Nov 28.

a Monash Clinical Toxicology Unit, Emergency Medicine Service, Monash Health , Melbourne , VIC , Australia.

Introduction: Levothyroxine overdose rarely results in systemic toxicity. We report a case of intentional levothyroxine overdose with a delayed onset coma and delirium lasting two weeks.

Case Summary: A 72-year-old female ingested 12 mg levothyroxine. Read More

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November 2018

Severe cholestatic jaundice associated with Graves' disease.

Clin Case Rep 2018 Nov 12;6(11):2240-2245. Epub 2018 Oct 12.

Division of General and Geriatric Medicine, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas.

We describe a rare case of Graves' disease presenting with atrial fibrillation and severe cholestasis. An extensive evaluation for hepatobiliary causes of cholestasis, including hepatic biopsy, was entirely negative. He was successfully treated with methimazole and eventual thyroidectomy. Read More

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November 2018
2 Reads

RESISTANCE TO THYROID HORMONE WITH A MUTATION OF THE THYROID β RECEPTOR GENE IN AN EIGHT-MONTH OLD INFANT: CASE REPORT.

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Katedra i Klinika Pediatrii i Endokrynologii Dziecięcej Śląskiego Uniwersytetu Medycznego w Katowicach, ul. Medyków 16, 40-752 Katowice, Poland.

Introduction: Resistance to thyroid hormone (RTHβ) is a rare syndrome of impaired tissue responsiveness to thyroid hormones (THs). The disorder has autosomal dominant or recessive pattern of inheritance. Most of reported mutations have been detected in the thyroid hormone receptor β gene (THRB). Read More

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November 2018
3 Reads

Heart rate variability in hyperthyroidism on sub Saharan African patients: a case-control study.

BMC Res Notes 2018 Nov 15;11(1):814. Epub 2018 Nov 15.

National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.

Objective: We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. Read More

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November 2018
5 Reads

Periodic paralysis with normokalemia in a patient with hyperthyroidism: A case report.

Medicine (Baltimore) 2018 Nov;97(46):e13256

Department of Emergency Medicine, Kaohsiung Medical University Hospital.

Rationale: Thyrotoxic periodic paralysis is characterized by a sudden onset of hypokalemia and paralysis. This condition mainly affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle without typical symptoms such as palpitations, tremors, anxiety, and weight loss; this causes a difficulty in early diagnosis. Read More

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November 2018
8 Reads

Thyrotoxic periodic paralysis complicated by life-threatening acute hypercapnic respiratory failure in a Chinese male with painless thyroiditis.

Am J Emerg Med 2018 Nov 7. Epub 2018 Nov 7.

Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Wenzhou 325027, China. Electronic address:

Context: Thyrotoxic periodic paralysis (TPP) is a relatively common complication seen in Asian hyperthyroid patients. However, it is a rare occurrence to find a TPP case comprised of acute hypercapnic respiratory failure in patients with painless thyroiditis.

Patient: A 29-year-old Chinese man presented with flaccid paralysis of all four limbs and he was brought to emergency room. Read More

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November 2018
1 Read

[CME Answers: 'Thyrotoxicosis and Thyroiditis', Praxis No. 22].

Authors:
Lea Slahor

Praxis (Bern 1994) 2018 Nov;107(23):1293

1 Endokrinologie/Diabetologie, Luzerner Kantonsspital, Luzern.

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November 2018

Controversies in the pharmacological treatment of Graves' disease in children.

Expert Rev Clin Pharmacol 2018 Nov 15;11(11):1113-1121. Epub 2018 Nov 15.

a UOC Pediatria, Department of Human Pathology of Adulthood and Childhood , University of Messina , Messina , Italy.

Introduction: Graves' disease (GD) is a disorder, in which auto-immunity against the thyroid- stimulating hormone (TSH) receptor is the pivotal pathogenetic element. This disease may have different clinical manifestations, the most common being thyrotoxicosis. Treatment of this condition differs according to its etiology, but there is currently no evidence-based therapeutic strategy which is universally adopted in all countries. Read More

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November 2018
1 Read

Resistant Thyrotoxicosis due to Graves' Disease in Pregnancy: Case Report and Review of the Literature.

Cureus 2018 Aug 30;10(8):e3232. Epub 2018 Aug 30.

Department of Endocrinology, Diabetes and Metabolism, E. Venizelou Hospital, Athens, GRC.

The effective management of Graves' disease (GD) during pregnancy is crucial for maternal and neonatal well-being. Conventional treatment of GD during pregnancy includes antithyroid drugs (ATDs) and surgery, ideally during the second trimester. We report a 27-year-old woman with GD and we present the course of GD during her three consecutive pregnancies. Read More

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August 2018
4 Reads

Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease.

J Endocr Soc 2018 Nov 17;2(11):1246-1250. Epub 2018 Sep 17.

Division of Endocrine and Diabetes, Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan.

Mitral valve prolapse is a common disorder, but severe mitral regurgitation (MR) as a result of rupture of mitral valve chordae tendineae is a rare manifestation of thyrotoxic heart disease. There are limited reports with respect to the onset of severe MR as a complication of Graves disease. We report a case of a 60-year-old woman with Graves disease and thyroid-associated ophthalmopathy as her past history. Read More

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November 2018
1 Read

Technetium-99m Thyroid Scintigraphy and Human Leukocyte Antigen - B35 in Sub-Acute Thyroiditis.

Indian J Nucl Med 2018 Oct-Dec;33(4):306-311

Departments of Nuclear Medicine, Endocrinology, Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Introduction: Sub-acute thyroiditis possibly caused by a viral infection of thyroid gland is associated with a surge in thyroxine levels of the patient. Women in the younger age group are affected more than men. Markedly decreased radioactive iodine thyroid uptakes in a setting of thyrotoxicosis associated with elevated thyroxine levels and reduced thyroid stimulating hormone levels usually clinches the diagnosis. Read More

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November 2018
4 Reads

A 2017 SURVEY OF THE CLINICAL PRACTICE PATTERNS IN THE MANAGEMENT OF RELAPSING GRAVES' DISEASE.

Endocr Pract 2018 Nov 1. Epub 2018 Nov 1.

From: 1Endocrine Institute, Assaf Harofeh Medical Center, Zerifin, Israel.

Objective: Previous surveys from different world regions have demonstrated variations in the clinical management of Graves' disease (GD). We aim to investigate the clinical approach to GD relapse among endocrinologists.

Methods: Electronic questionnaires were e-mailed to all members of the Israeli Endocrine Society. Read More

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November 2018
4 Reads

National Trends in Incidence, Mortality and Clinical Outcomes of Patients Hospitalized for Thyrotoxicosis with and without Thyroid Storm in the United States, 2004-2013.

Thyroid 2018 Nov 1. Epub 2018 Nov 1.

Emory University School of Medicine, 12239, Division of Endocrinology, Atlanta, Georgia, United States ;

Background: Current evidence on the incidence and outcomes of patients with thyroid storm in the US is limited to single-center case series. We determined the national incidence of thyrotoxicosis with and without thyroid storm and clinical outcomes among hospitalized patients during a 10-year period in the US.

Methods: Retrospective longitudinal analysis of clinical characteristics, mortality, hospital length-of-stay and costs from 2004 and 2013. Read More

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November 2018

[CME: Thyrotoxicosis and Thyroiditis].

Authors:
Lea Slahor

Praxis (Bern 1994) 2018;107(22):1187-1192

1 Endokrinologie/Diabetologie, Luzerner Kantonsspital, Luzern.

Hyperthyroidism is caused by an increased synthesis of thyroid hormones or release of preformed thyroid hormones due to destruction of thyroid tissue, or there is an exogenous extrathyroidal source. The term thyroiditis describes a heterogeneous group of disorders, which result in destruction of thyroid tissue and release of preformed thyroid hormones. Although a less common condition, a thyroiditis remains an important differential diagnosis for thyrotoxicosis, and a symptomatic therapy is the cornerstone of treatment. Read More

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January 2018
3 Reads

Thyroidectomy for Amiodarone-Induced Thyrotoxicosis: Mayo Clinic Experience.

J Endocr Soc 2018 Nov 6;2(11):1226-1235. Epub 2018 Sep 6.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota.

Context: Amiodarone-induced thyrotoxicosis (AIT) is a difficult diagnostic and management challenge, especially during severe thyrotoxicosis accompanied by cardiovascular compromise.

Objective: To evaluate thyroidectomy for the management of AIT.

Design: Retrospective cohort study of adults with noncongenital heart disease with AIT after >3 months of amiodarone who underwent thyroidectomy from 1 November 2002 to 31 December 2016. Read More

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November 2018
7 Reads

Clinical Characteristics of Febrile Outpatients : Possible Involvement of Thyroid Dysfunction in Febrile Tachycardia.

Acta Med Okayama 2018 Oct;72(5):447-456

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Read More

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October 2018
6 Reads

Investigational drugs in early stage clinical trials for thyrotoxicosis with hyperthyroidism.

Expert Opin Investig Drugs 2018 Nov 31;27(11):831-837. Epub 2018 Oct 31.

a Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Endocrinology Department , Hospital Universitario de Bellvitge , Barcelona , Spain.

Introduction: Thyrotoxicosis with hyperthyroidism is treated with these classical approaches (i) antithyroid drugs to blockade thyroid hormone release and normalize thyroid hormone production and (ii) destruction of the thyroid using radioiodine or surgical removal of the thyroid. The optimal medical therapy, especially for Graves´ disease, remains a subject of debate and there has been little progress in Graves' disease therapeutics over the last decade. Areas covered: Novel treatments of thyrotoxicosis with hyperthyroidism. Read More

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November 2018
11 Reads

Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families.

Clin Epidemiol 2018 10;10:1447-1455. Epub 2018 Oct 10.

Division or Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK,

Purpose: To estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks.

Patients And Methods: This population-based study used the Taiwan National Health Insurance database to reconstruct family structure and identify people with T1D and other chronic diseases between 1999 and 2015. Relative risks (RRs) for T1D and other chronic diseases and heritability of T1D were estimated. Read More

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October 2018
1 Read

Destructive Thyroiditis Induced by Lenvatinib in Three Patients with Hepatocellular Carcinoma.

Intern Med 2018 Oct 17. Epub 2018 Oct 17.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan.

Hypothyroidism is a frequently occurring complication in patients on lenvatinib treatment. However, little is known about lenvatinib-induced thyrotoxicosis and destructive thyroiditis. We herein report the cases of three patients who developed hyperthyroidism during the course of lenvatinib treatment. Read More

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October 2018
1 Read

A pediatric case with prostaglandin I-associated thyrotoxicosis: Case report and the literature review.

J Clin Res Pediatr Endocrinol 2018 10 16. Epub 2018 Oct 16.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Prostaglandin I (PGI2) causes hyperthyroidism, a critical complication in patients with pulmonary arterial hypertension (PAH). However, it remains unknown whether PGI2 may have unfavorable effects on thyroid functions in children with congenital portosystemic venous shunt syndrome (CPSVS). We present a boy with CPSVS who developed PAH at 7 years of age. Read More

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October 2018
2 Reads

Weathering the storm: A case of thyroid storm refractory to conventional treatment benefiting from therapeutic plasma exchange.

J Clin Apher 2018 Dec 15;33(6):678-681. Epub 2018 Oct 15.

Department of Pathology, Division of Transfusion Medicine, University of Texas Medical Branch, Galveston, Texas.

Thyroid storm is a severe manifestation of thyrotoxicosis characterized by systemic organ dysfunction secondary to a hypermetabolic state. Although antithyroid drugs, steroids, beta-blockers, antipyretics, and cholestyramine are the standard of care, some patients inadequately respond to these conventional therapies. Therapeutic plasma exchange has been previously utilized as a treatment modality in patients with a poor response to routine therapies or with contraindications to them. Read More

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December 2018

Thyroiditis and immune check point inhibitors: the post-marketing experience using the French National Pharmacovigilance database.

Fundam Clin Pharmacol 2018 Oct 11. Epub 2018 Oct 11.

Department of Clinical Pharmacology and Pharmacovigilance, University Hospital of Nancy, 29 avenue du Maréchal de Lattre de Tassigny, Nancy, 54035, France.

Immunotherapy with immune checkpoint inhibitors (ICIs) for cancer has become increasingly prescribed in recent years. Indeed, it is used to treat both solid and hematological malignancies due to their considerable potential in treating melanoma, non-small cell lung and other cancers. Immune-mediated related adverse endocrine toxicity, and especially thyroiditis, is seen as a growing problem needing specific screening and management. Read More

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October 2018
2 Reads

Thyrotoxic hypokalemic periodic paralysis: a life-threatening disorder in Asian men.

Trop Doct 2018 Oct 10:49475518803251. Epub 2018 Oct 10.

2 Professor, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Thyrotoxicosis can present as a sporadic form of hypokalaemic periodic paralysis. The condition is associated with massive intracellular shift of potassium, mainly in skeletal muscles. As the total body stores of potassium remain normal, overzealous potassium supplementation targeting serum potassium level results in a poor outcome. Read More

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October 2018
4 Reads

Predicting outcomes and complications following radioiodine therapy in Graves' thyrotoxicosis.

Clin Endocrinol (Oxf) 2018 Oct 6. Epub 2018 Oct 6.

Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK.

Objective: Radioiodine (RAI) is an effective treatment for Graves' thyrotoxicosis but is associated with a failure rate of 15% and may be a risk factor for thyroid eye disease (TED) and weight gain. We sought to examine predictors of RAI failure, weight gain, TED and patient satisfaction.

Design: Retrospective cohort study. Read More

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October 2018
4 Reads

MANAGEMENT OF THYROTOXICOSIS: PRECONCEPTION, PREGNANCY, AND THE POSTPARTUM PERIOD.

Endocr Pract 2018 Oct 5. Epub 2018 Oct 5.

From: Section of Endocrinology, Diabetes, and Nutrition; Boston University School of Medicine.

Objective: To review the diagnosis and management of thyrotoxicosis in women who are preconception, pregnant, and in the postpartum period.

Methods: Literature review of English-language papers published 1980-2018.

Results: Overt thyrotoxicosis occurs in 0. Read More

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October 2018
11 Reads

2018 European Thyroid Association Guideline for the Management of Graves' Hyperthyroidism.

Eur Thyroid J 2018 Aug 25;7(4):167-186. Epub 2018 Jul 25.

Department of Endocrinology, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Graves' disease (GD) is a systemic autoimmune disorder characterized by the infiltration of thyroid antigen-specific T cells into thyroid-stimulating hormone receptor (TSH-R)-expressing tissues. Stimulatory autoantibodies (Ab) in GD activate the TSH-R leading to thyroid hyperplasia and unregulated thyroid hormone production and secretion. Diagnosis of GD is straightforward in a patient with biochemically confirmed thyrotoxicosis, positive TSH-R-Ab, a hypervascular and hypoechoic thyroid gland (ultrasound), and associated orbitopathy. Read More

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August 2018
13 Reads

[Challenges in the management of amiodarone-induced thyrotoxicosis].

Presse Med 2018 Sep 28;47(9):746-756. Epub 2018 Sep 28.

CHU Clermont-Ferrand, service d'endocrinologie, diabétologie et maladies métaboliques, 63003 Clermont-Ferrand, France; Laboratoire GReD : UMR université Clermont Auvergne-CNRS 6293, Inserm U1103, BP 10448, 63177 Aubiere, France.

Amiodarone, a benzofuranic iodine-rich pan antiarrhythmic drug, is frequently associated with thyroid dysfunction. This side effect is heterogeneous and unpredicted, motivating regular evaluation of thyroid function tests. In contrary to hypothyroidism, amiodarone-induced thyrotoxicosis (AIT) is a challenging situation owing to the risk of deterioration of the general and cardiac status of such debilitating patients. Read More

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September 2018
1 Read

Prospective Echocardiographic Evaluation of Right Ventricle and Pulmonary Arterial Pressure in Hyperthyroid Patients.

Heart Lung Circ 2018 Sep 12. Epub 2018 Sep 12.

Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University - UNESP, Botucatu, Sao Paulo, Brazil. Electronic address:

Background: Pulmonary arterial hypertension (PAH) occurs in 35% to 65% of hyperthyroid patients. Despite this high frequency, only a few authors have examined the effects of hyperthyroidism treatment on PAH and the right ventricle. We evaluated the effects of hyperthyroidism and its reversal on cardiovascular structure and function using Doppler echocardiography. Read More

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September 2018
5 Reads

Thyroid disorders induced by checkpoint inhibitors.

Rev Endocr Metab Disord 2018 Sep 21. Epub 2018 Sep 21.

Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Via Savi, 10, I-56126, Pisa, Italy.

Immune checkpoint inhibitors are drugs that inhibit the "checkpoint molecules". Different types of cancer immune checkpoint inhibitors have been approved recently: CTLA-4 monoclonal antibodies (as ipilimumab); anti-PD-1 monoclonal antibodies (as pembrolizumab and nivolumab); and anti-PD-L1 monoclonal antibodies (as atezolizumab, avelumab, and durmalumab). The increased immune response induced by these agents leads to immune-related adverse events (irAEs), that can vary from mild to fatal, according to the organ system and severity. Read More

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September 2018
6 Reads

Diagnosis and Clinical Course of Three Adolescents with Amiodarone-Induced Hyperthyroidism.

Pediatr Cardiol 2018 Dec 21;39(8):1707-1716. Epub 2018 Sep 21.

Hospital for Children and Adolescents, University Leipzig, Liebigstr. 20a, 04103, Leipzig, Germany.

Amiodarone-induced hyperthyroidism is a known side effect of amiodarone treatment. In the pediatric population, long-term amiodarone treatment is rarely indicated because of its severe side effects including thyroid function impairment. Treatment is therefore restricted to therapy-resistant arrhythmias. Read More

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December 2018
2 Reads

Adverse effects of amiodarone therapy in adults with congenital heart disease.

Congenit Heart Dis 2018 Sep 21. Epub 2018 Sep 21.

Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Objective: Amiodarone is a highly effective antiarrhythmic therapy, however its toxicity profile often limits treatment. This is particularly relevant in adults with congenital heart disease (CHD), who are often young and in whom other antiarrhythmic agents commonly fail or are contraindicated. We sought to determine incidence and predictors of adverse effects caused by amiodarone in adult CHD (ACHD). Read More

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September 2018
1 Read

Issues in amiodarone-induced thyrotoxicosis: Update and review of the literature.

Ann Endocrinol (Paris) 2018 Sep 17. Epub 2018 Sep 17.

Service d'endocrinologie, diabétologie et maladies métaboliques, CHU Clermont-Ferrand, 63003 Clermont-Ferrand, France; Laboratoire GReD, UMR Université Clermont Auvergne-CNRS 6293, Inserm U1103, BP 10448, 63177 Aubière, France.

Amiodarone, a benzofuranic iodine-rich pan-anti-arrhythmic drug, induces amiodarone-induced thyrotoxicosis (AIT) in 7-15% of patients. AIT is a major issue due to its typical severity and resistance to anti-thyroid measures, and to its negative impact on cardiac status. Classically, AIT is either an iodine-induced thyrotoxicosis in patients with abnormal thyroid (type 1), or due to acute thyroiditis in a "healthy" thyroid (type 2). Read More

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September 2018
1 Read

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone.

Front Endocrinol (Lausanne) 2018 28;9:486. Epub 2018 Aug 28.

Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Evidence shows that sympathetic nervous system (SNS) activation inhibits bone formation and activates bone resorption leading to bone loss. Because thyroid hormone (TH) interacts with the SNS to control several physiological processes, we raised the hypothesis that this interaction also controls bone remodeling. We have previously shown that mice with double-gene inactivation of α2A- and -adrenoceptors (α2A/2C-AR) present high bone mass (HBM) phenotype and resistance to thyrotoxicosis-induced osteopenia, which supports a TH-SNS interaction to control bone mass and suggests that it involves α2-AR signaling. Read More

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Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab.

Cancer Sci 2018 Nov 13;109(11):3583-3590. Epub 2018 Oct 13.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Thyroid dysfunction (TD) induced by immune checkpoint inhibitors is not sufficiently understood. The purpose of this retrospective observational study was to identify risk factors and the clinical course of TD induced by nivolumab. Patients with advanced solid tumors who were treated with nivolumab from March 2009 through to March 2016 at the National Cancer Center Hospital (Tokyo, Japan) were included. Read More

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November 2018

Diagnostic procedure in suspected Graves' disease.

Ann Endocrinol (Paris) 2018 Dec 18;79(6):608-617. Epub 2018 Aug 18.

Service d'endocrinologie, CHU de Rabat, Rabat, Morocco.

Diagnostic procedure in suspected Graves' disease has never been studied scientifically and actual practice seems quite variable, notably between countries. Recommendations are few and weak (expert opinion). This article presents the recommendations of an expert consensus meeting organized by the French Society of Endocrinology in 2016. Read More

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December 2018
1 Read

Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate-to-severe Graves' ophthalmopathy - a 1-year follow-up: study protocol for a randomized controlled trial.

Trials 2018 Sep 15;19(1):495. Epub 2018 Sep 15.

Department of Ophthalmology, Medical University Vienna, Vienna, Austria.

Background: Graves' disease (GD) is characterized by thyrotoxicosis and goiter and arises through circulating autoantibodies that bind to, and stimulate, the thyroid hormone receptor (TSHR). A temporal relation between the onset of hyperthyroidism and the onset of ophthalmopathy, a common extrathyroidal manifestation, has been demonstrated. Graves' ophthalmopathy (GO) is typically characterized by an inflammation and expansion of the extraocular muscles and an increase in retroorbital fat. Read More

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September 2018
5 Reads

Thyrotoxic periodic paralysis: case report and review of the literature.

Electron Physician 2018 Aug 25;10(8):7174-7179. Epub 2018 Aug 25.

MD., Assistant Professor, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, USA.

Introduction: Thyrotoxic periodic paralysis (TPP) is a rare and potentially lethal complication of hyperthyroidism. It is characterized by sudden onset paralysis associated with hypokalemia. Management includes prompt normalization of potassium, which results in resolution of the paralysis. Read More

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August 2018
2 Reads

An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report.

Int J Surg Case Rep 2018 5;51:218-220. Epub 2018 Sep 5.

Pathology Department, Ardabil University of Medical Sciences, Ardabil, Iran.

Introduction: Struma ovarii is an ovarian tumor with thyroid tissue as its predominant component. It usually occurs in older women and presents with abdominal mass, pain and abnormal bleeding. Most patients are euthyroid, but some reports have noted thyrotoxicosis originating from the malignant struma ovarii. Read More

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September 2018
2 Reads

Management of Amiodarone-Induced Thyrotoxicosis at a Cardiac Transplantation Centre.

Front Endocrinol (Lausanne) 2018 22;9:482. Epub 2018 Aug 22.

Department of Endocrinology, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.

Amiodarone-induced thyrotoxicosis (AIT) is associated with significant morbidity and mortality, particularly in patients with cardiac failure. The aim of the study was to evaluate the management of AIT at a tertiary hospital specialising in cardiac failure and transplantation. Retrospective audit of 66 patients treated for AIT by Endocrinology (2007-2016), classified as type 1 (T1) or type 2 (T2) based on radiological criteria. Read More

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August 2018
1 Read

[An enlarged thymus associated with Graves' disease].

Ned Tijdschr Geneeskd 2018 Jul 20;162. Epub 2018 Jul 20.

Scheper Ziekenhuis, afd. Endocrinologie, Emmen.

Background: Thyrotoxicosis and orbitopathy are the best-known expressions of Graves' disease. There are also rarer and less-known phenomena, such as thymic hyperplasia. Identification of these is important in order to avoid potentially unnecessary invasive interventions. Read More

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July 2018
2 Reads

Rapidly Progressing Fatal High-Altitude Illness in a Patient with Hyperthyroidism.

Authors:
Sang Jae Noh Ho Lee

High Alt Med Biol 2018 Sep 4;19(3):288-290. Epub 2018 Sep 4.

Department of Forensic Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences , Jeonju-si, Korea.

Noh, Sang Jae and Ho Lee. Rapidly progressing fatal high-altitude illness in a patient with hyperthyroidism. High Alt Med Biol. Read More

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September 2018
7 Reads

Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study.

Authors:
Zheng Feei Ma

Clin Endocrinol (Oxf) 2018 Nov 20;89(5):677-678. Epub 2018 Sep 20.

Department of Public Health, Xi'an Jiaotong-Liverpool University, Suzhou, China.

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November 2018