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Medicine (Baltimore) 2019 Mar;98(9):e14675

Department of Endocrinology, Xiangya Hospital, Changsha, Central South University.

Rational: Thyroid hormone resistance (RTH) is a rare disease that is characterised by a lowered sensitivity of the target organs to thyroid hormone. Herein, we present 3 cases of confirmed RTH, with the support of clinical lab results and/or gene sequencing at diagnosis.

Patient Concerns: The 3 included patients were found to have elevated levels of free T3 (FT3), free T4 (FT4), and non-supressed levels of thyroid stimulating hormone (TSH). Read More

Medicine (Baltimore) 2019 Feb;98(8):e14606

Department of Nuclear Medicine, Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry.

Rationale: Thyroid hemiagenesis is a rare congenital dysplasia, whereas a variety of pathological changes may occur in residual thyroid lobe. The most frequently described pathology in residual thyroid lobe is Graves' hyperthyroidism. Although I therapy has been generally recommended as the preferred treatment for Graves' disease (GD), subjects relating to hemiagenesis are very limited, especially in China. Read More

Endocrine 2019 Feb 25. Epub 2019 Feb 25.

Department of Endocrinology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Purpose: Nivolumab is a monoclonal antibody that blocks the activation of programmed death-1 receptor, promoting T-cell activation against cancer cells. Thyroid dysfunction (TD) is a common immune-related adverse event (irAE) induced by nivolumab. We report the prevalence, patterns and outcomes of nivolumab-induced TD among cancer patients in our center. Read More

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):34-39. Epub 2019 Feb 4.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: A hypercalcaemic crisis, also called para thyrotoxicosis, hyper parathyroid crisis or parathyroid storm, is a complication of primary hyperparathyroidism (PHPT) and an endocrinology emergency that can have dramatic or even fatal consequences if it is not recognised and treated in time.

Case Presentation: Two cases presented in the emergency department with critical hypercalcaemic symptoms and severe elevation of serum calcium and parathyroid hormone levels, consistent with a hypercalcaemic crisis. The first case, a 16-year-old female patient, had imaging data that highlighted a single right inferior parathyroid adenoma and a targeted surgical approach was used. Read More

Clin Nucl Med 2019 Apr;44(4):327-329

From the Departments of Nuclear Medicine.

A 66-year-old man with follicular thyroid cancer after total thyroidectomy was referred for I therapy. Thyroid function tests before I administration exhibited severe thyrotoxicosis although the patient did not take levothyroxine after thyroidectomy. A 185 MBq I whole-body scintigraphy and SPECT/CT revealed multiple iodine-avid pulmonary metastases with the largest tumor diameter of 1. Read More

Endocr Pathol 2019 Mar;30(1):74-80

Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

Thyrotropin (TSH)-secreting pituitary tumors are the rarest functioning pituitary tumors. Nonetheless, they are not infrequently plurihormonal, as they may express/secrete hormones made by other pituitary cells derived from the Pit-1 lineage such as growth hormone (GH), prolactin (PRL), and α-subunit (αSU). However, adrenocorticotropin (ACTH) or gonadotropin secretion by such a tumor is exceptional. Read More

Ann Endocrinol (Paris) 2018 Dec 18;79(6):608-617. Epub 2018 Aug 18.

Service d'endocrinologie, CHU de Rabat, Rabat, Morocco.

Diagnostic procedure in suspected Graves' disease has never been studied scientifically and actual practice seems quite variable, notably between countries. Recommendations are few and weak (expert opinion). This article presents the recommendations of an expert consensus meeting organized by the French Society of Endocrinology in 2016. Read More

Ned Tijdschr Geneeskd 2018 Jul 20;162. Epub 2018 Jul 20.

Scheper Ziekenhuis, afd. Endocrinologie, Emmen.

Background: Thyrotoxicosis and orbitopathy are the best-known expressions of Graves' disease. There are also rarer and less-known phenomena, such as thymic hyperplasia. Identification of these is important in order to avoid potentially unnecessary invasive interventions. Read More

Clin Nucl Med 2018 Sep;43(9):655-662

From the Department of Medicine (DIMED), Endocrinology Unit, and.

Purpose Of The Report: Distinguishing between amiodarone-induced thyrotoxicosis (AIT) caused by excessive hormone synthesis (AIT-1) or by a destructive process (AIT-2) has important therapeutic implications, but is still difficult and debated. Tc-sestaMIBI thyroid scintigraphy (99m-STS) has been proposed as a tool for classifying the two forms.

Material And Methods: 30 AIT patients (11 females and 19 males) who underwent 99m-STS were retrospectively assessed for the present study. Read More

BMJ Case Rep 2018 Jul 3;2018. Epub 2018 Jul 3.

Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.

We report a case of a 27-year-old man with a history of untreated HIV who presented with fever, rash and leg cramps. Initial suspicion was high for an infectious process; however, after an exhaustive evaluation, thyrotoxicosis was revealed as the aetiology of his symptoms. Recent intravenous contrast administration complicated his workup to determine the exact cause of hyperthyroidism. Read More

Australas Phys Eng Sci Med 2018 Sep 25;41(3):747-756. Epub 2018 Jun 25.

Nuclear Medicine, SA Medical Imaging, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, 5006, Australia.

Radioiodine (I) therapies on younger children with thyroid cancer and neuroblastoma can be challenging as they are required to be isolated for a period of time due to radiation safety concerns. At our hospital these therapies are performed in a purpose-built child-friendly therapy room. Nursing staff are able to provide personal care during the isolation period with minimum radiation exposure. Read More

Ann Otol Rhinol Laryngol 2018 Aug 17;127(8):558-562. Epub 2018 Jun 17.

1 Section of Endocrinology and Metabolism, Department of Internal Medicine, Louisiana State University Health Sciences Center in Shreveport, Shreveport, Louisiana, USA.

Objectives: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. Read More

Medicine (Baltimore) 2018 Jun;97(24):e11047

Department of Endocrinology and Metabolism.

Rationale: Thyrotropin-secreting adenoma (TSHoma) is rare. Even though the thyrotoxicosis is mild in patients with TSHoma, it is still a rare cause of arrhythmia, ignore of mild disfunction of thyroid function of TSHoma can lead to the delayed diagnosis of pituitary tumor or leading to recurring of complications. Graves' disease is an auto-immue endocrinological disorder. Read More

Acta Otorrinolaringol Esp 2019 Mar - Apr;70(2):61-67. Epub 2018 Jun 9.

Servicio de Otorrinolaringología, Hospital Clínico Universitario de Valencia, Valencia, España.

Background: Thyroid abscess or acute suppurative thyroiditis is an unusual clinical condition. We present our experience with cases attended over 41 years.

Materials And Methods: A retrospective study was performed on these patients reviewing their epidemiological characteristics and the diagnostic and therapeutic manoeuvres chosen for them all, as well as their clinical outcome. Read More

BMJ Case Rep 2018 May 2;2018. Epub 2018 May 2.

Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland Medical Center, Baltimore, Maryland, USA.

Anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis is a novel disease discovered within the past 10 years. It is an autoimmune disease (AD) that has been associated with other ADs, such as Graves' disease. However, association with autoimmune polyglandular syndromes (APS) has not been previously described. Read More

Endocr J 2018 Jul 26;65(7):737-746. Epub 2018 Apr 26.

Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.

A 29-year-old man was referred to our department due to adrenal insufficiency with the inappropriate secretion of TSH (SITSH). Magnetic resonance imaging revealed a pituitary tumor. A weak TSH response in the TRH test, elevated sex hormone binding globulin (SHBG) levels, and the absence of a family medical history of SITSH or TRβ gene mutations supported the diagnosis of TSH-secreting pituitary adenoma (TSHoma). Read More

Pol J Radiol 2017 15;82:536-541. Epub 2017 Sep 15.

Department of Internal Medicine, Mansoura Faculty of Medicine, Mansoura, Egypt.

Background: To assess the role of diffusion-weighted MR imaging in differentiation between Graves' disease and painless thyroiditis.

Material/methods: A prospective study was conducted among 37 consecutive patients with untreated thyrotoxicosis (25 female and 12 male; mean age of 44 years) and 15 ageand sex-matched controls. Diffusion-weighted MR imaging of the thyroid gland was performed in patients and controls. Read More

Exp Clin Endocrinol Diabetes 2018 Jun 20;126(6):333-341. Epub 2018 Mar 20.

Department of Endocrinology, Diabetes & Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom, LA1 4RP.

Amiodarone is one of the most commonly prescribed antiarrhythmic agents in clinical practice owing to its efficacy, even with high toxicity profile. The high iodine content and the prolonged biological half-life of the drug can result in thyroid dysfunction in a high proportion of patients treated with amiodarone even after cessation of amiodarone. Both hypothyroidism and hyperthyroidism are common side effects that mandate regular monitoring of patients with thyroid function tests. Read More

Am J Ther 2018 Nov/Dec;25(6):e666-e669

Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL.

Clinical Features: The patient we present is a 39-year-old woman with a history of hyperthyroidism who developed fast atrial fibrillation secondary to thyrotoxic storm. After the initiation of intravenous diltiazem drip, she developed hypotension, bradycardia, then asystole cardiac arrest.

Therapeutic Challenge: It is well known that calcium channel blockers and beta blockers should be used with extreme caution if the patient with thyroid storm has decompensated heart failure with reduced ejection fraction. Read More

Intern Med 2018 Jul 28;57(13):1939-1942. Epub 2018 Feb 28.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.

We herein report a case of central diabetes insipidus complicated with thyroid storm. A middle-aged woman who was receiving treatment for Graves' disease suddenly complained of polydipsia, polyuria and general fatigue. Laboratory tests showed hyperthyroidism, hypernatremia, hypoosmolar urine and a decreased plasma vasopressin level. Read More

In Vivo 2018 Mar-Apr;32(2):345-351

The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.

Background: Immune-checkpoint inhibitors (ICIs) are novel promising agents for the treatment of malignant tumors. However, critical endocrine immune-related adverse events (irAEs) by ICIs often occur.

Case Report: A 63-year-old woman with advanced malignant melanoma had received anti-PD-1 antibody (nivolumab, 2 mg/kg every 3 weeks) for 8 cycles (from day 0 to day 147). Read More

J Med Case Rep 2018 Feb 23;12(1):51. Epub 2018 Feb 23.

Department of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Pyrexia of unknown origin is a difficult and challenging problem for the physician. Endocrine disorders, such as subacute thyroiditis, rarely present with pyrexia of unknown origin. Subacute thyroiditis can have a broad spectrum of clinical presentations including fever and biochemical thyrotoxicosis without overt signs or symptoms. Read More

Medicine (Baltimore) 2018 Feb;97(7):e9949

Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Johnan-cho, Hitachi, Ibaraki, Japan.

Rationale: Various neurological manifestations are observed in thyroid storm patients but protracted disturbance of consciousness is rare.

Patient Concerns: A 58-year-old male was admitted to our hospital after a traffic accident.

Diagnoses: Although awake on arrival, he fell into coma after admission. Read More

Medicine (Baltimore) 2017 Dec;96(50):e8912

Department of Endocrinology.

Rationale: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are exceedingly rare. To date, there are only 6 cases reported. Here, we describe an even rarer ectopic TSH-secreting pituitary adenoma (TSH-oma) concomitant with papillary thyroid carcinoma. Read More

Sultan Qaboos Univ Med J 2017 Nov 10;17(4):e460-e463. Epub 2018 Jan 10.

Department of Neurology, Royal Hospital, Muscat, Oman.

Acute polyneuropathy is a rare manifestation of severe hyperthyroidism. We report a 22-year-old Omani male who presented to the Sohar Hospital, Sohar, Oman, in 2016 with acute-onset rapidly progressive flaccid areflexic paraplegia as the presenting manifestation of thyrotoxicosis. Nerve conduction studies revealed mixed axonal and demyelinating polyneuropathy in both the motor and sensory nerves. Read More

Medicina (B Aires) 2018;78(1):44-46

Servicio de Endocrinología, Servicio de Endocrinología y Metabolismo, Complejo Médico Churruca-Visca, Buenos Aires, Argentina.

Hyperthyroidism is defined as an excessive production of thyroid hormones by eutopic or ectopic mature thyroid tissue. The overall prevalence of hyperthyroidism is 1.2% and the most common cause is Graves' disease. Read More

Endokrynol Pol 2018 10;69(1):28-31. Epub 2018 Jan 10.

Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University.

Introduction: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seldom been reported to cause thyrotoxicosis. Read More

Case Rep Neurol 2017 Sep-Dec;9(3):228-233. Epub 2017 Oct 16.

Department of Internal Medicine, Botucatu School of Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, São Paulo, Brazil.

We report a case of a male patient with stroke caused by atrial fibrillation (AF) due to thyrotoxicosis. At hospital admission, he presented hypertension and AF. Magnetic resonance imaging confirmed a right-side ischemic area. Read More

BMJ Case Rep 2017 Nov 27;2017. Epub 2017 Nov 27.

Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

A 13-½-year-old boy was referred to the Department of Endocrinology as a case of thyrotoxicosis for initiation of antithyroid medication. His chief complaint was a swelling in front of the neck, which was incidentally noted by his mother 2 weeks prior to presentation. He denied any history of symptoms suggestive of hyperthyroidism or ophthalmological involvement. Read More

J Emerg Med 2017 Dec 6;53(6):e125-e128. Epub 2017 Nov 6.

Virginia Tech Carilion Emergency Medicine Residency, Department of Emergency Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia.

Background: Thyroid storm (also known as thyroid or thyrotoxic crisis) is part of the spectrum of thyrotoxicosis and represents the extreme end of that spectrum. The condition is quite rare, yet mortality rates are high and may approach 10-30%.

Case Report: A 34-year-old-man who had a history of Graves disease presented in atrial fibrillation with rapid ventricular response and mild congestive heart failure. Read More

Osteoporos Int 2018 01 25;29(1):237-241. Epub 2017 Oct 25.

Section on Skeletal Disorders and Mineral Homeostasis, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

In fibrous dysplasia/McCune-Albright syndrome (FD/MAS), bone and bone marrow are, to varying degrees, replaced by fibro-osseous tissue typically devoid of hematopoietic marrow. Despite the extensive marrow replacement in severely affected patients, bone marrow failure is not commonly associated with FD/MAS. We present a 14-year-old girl with FD/MAS, who developed pancytopenia and extramedullary hematopoiesis (EMH) with no identified cause, in the setting of iatrogenic thyrotoxicosis and hyperparathyroidism. Read More

Korean J Pediatr 2017 Aug 14;60(8):266-271. Epub 2017 Aug 14.

Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.

Purpose: The aim of this study was to assess the clinical characteristics of hypertensive encephalopathy according to the underlying etiologies in children.

Methods: We retrospectively evaluated 33 pediatric patients who were diagnosed as having hypertensive encephalopathy in Chonbuk National University Children's Hospital. Among the patients, 18 were excluded because of incomplete data or because brain magnetic resonance imaging (MRI) was not performed. Read More

Clin Med (Lond) 2017 Oct;17(5):453-457

Kings College London, London, UK.

Molecular radiotheragnostics directly links nuclear medicine diagnostic imaging to therapy. The imaging study is used to detect a specific molecular target associated with a disease process. A radiotherapeutic molecule with a similar biodistribution to the diagnostic agent can then be used to deliver targeted therapy. Read More

Ther Adv Endocrinol Metab 2017 Jul 12;8(7):111-115. Epub 2017 Sep 12.

Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, 920 Madison Ave, Suite 300A, Memphis TN 38163, USA.

Background: Radioactive iodine (RAI) is the most cost effective therapy for Graves' disease (GD). Patients with GD who have become hypothyroid after therapeutic RAI, rarely develop recurrence of disease. Herein we describe a case of recurrence of thyrotoxicosis after 2 years of hypothyroidism. Read More

Endocrinol Diabetes Metab Case Rep 2017 29;2017. Epub 2017 Aug 29.

Regional Centre for Endocrinology, Royal Victoria Hospital, BelfastUK.

A 42-year-old male presented with a one-week history of palpitations and sweating episodes. The only significant history was of longstanding idiopathic dilated cardiomyopathy. Initial ECG demonstrated a sinus tachycardia. Read More

BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.

Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand.

We present two patients with Graves' disease and concurrent myasthenia gravis. The impact of the dual diagnosis on the clinical course and the potential for a delayed diagnosis of myasthenia gravis is discussed. Patient 1, a 28-year-old man was diagnosed with Graves' disease following his second respiratory arrest. Read More

Curr Radiopharm 2017 Nov;10(3):146-154

Ion Chiricuta Institute of Oncology, Cluj-Napoca, Romania.

Background And Objective: The use of amiodarone for the treatment of ventricular and supraventricular dysrhythmias brings in organism an increased amount of iodine, interfering with thyroid function. If the treatment needs to be interrupted, iodine remains at abnormal levels for months or even years. The aim of the study was to review the literature regarding the optimal tests for early diagnostic and to analyze the role of nuclear medicine tests in the differential and correct assessment of the amiodarone-induced thyroid pathology. Read More

J Stroke Cerebrovasc Dis 2017 Oct 2;26(10):e195-e196. Epub 2017 Aug 2.

First Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background: Non-traumatic convexity subarachnoid hemorrhage (cSAH) is a rarely reported condition with a wide spectrum of etiologies. Cerebral ischemia secondary to extracranial or intracranial atherosclerotic disease has been identified as a relatively uncommon cause of cSAH.

Case Report: We report a case of cSAH caused by cardioembolic stroke. Read More

Intern Med 2017 1;56(15):2053-2056. Epub 2017 Aug 1.

Department of Neurology, Akita Red Cross Hospital, Japan.

Neuromuscular disorders associated with hyperthyroidism have several variations in their clinical phenotype, such as ophthalmopathy, periodic paralysis, and thyrotoxic myopathy. We herein report an unusual case of thyrotoxic myopathy presenting as unilateral drop foot. Histopathological examinations of the left tibialis anterior muscle showed marked variation in the fiber size, mild inflammatory cell infiltration, and necrotic and regenerated muscle fibers with predominantly type 1 fiber atrophy. Read More

Medicine (Baltimore) 2017 Aug;96(31):e7700

Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

Graves disease is the most common cause of thyrotoxicosis. Although medical intervention with antithyroid drugs (ATDs) is commonly the first choice of treatment in Korea, the remission rate associated with this approach is not satisfactory. During ATD therapy, low or undetectable serum levels of thyroid-stimulating hormone (TSH) receptor antibodies (TRAbs) have been reported to affect the incidence of Graves disease remission. Read More

Medicine (Baltimore) 2017 Jul;96(30):e7535

aPET Imaging Center, Asahi General Hospital bDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba cDepartment of Diagnostic Radiology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo dDepartment of Radiology, Asahi General Hospital, Chiba, Japan.

Background: In addition to its established role in oncologic imaging, F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is useful for the assessment of inflammatory activity. However, subacute thyroiditis (SAT) in thyrotoxicosis is rarely detected during these scans.

Case: A 66-year-old man with SAT in thyrotoxicosis demonstrated symptoms of transient fatigue, headache, and fever, without typical neck pain. Read More

Hormones (Athens) 2017 Apr;16(2):194-199

Pediatric Neurological, Clinical University Hospital of Santiago de Compostela, Santiago, Spain.

Monocarboxylate transporter 8 (MCT8) is an active and specific thyroid hormone transporter into neurons. MCT8 mutations cause an X-linked condition known as Allan-Herndon-Dudley syndrome and are characterized by impaired psychomotor development and typical abnormal thyroid function. We describe a 10-year-old boy with severe cognitive disability, axial hypotonia, spastic quadriplegia and sporadic dyskinetic episodes. Read More

Ultrasound Obstet Gynecol 2017 07;50(1):132-134

Department of Paediatrics, Sainte-Justine University Hospital Center, University of Montreal, 3175 Chemin de la Côte Sainte Catherine, Montreal, Quebec, H3T 1C5, Canada.

Cardiol J 2017;24(3):342-343

Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland, Switzerland.

Neurologist 2017 Jul;22(4):134-137

*Neurology Department, Papageorgiou General Hospital ‡Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece †Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background: Thyrotoxic periodic paralysis (TPP) is an uncommon complication of Graves' disease, characterized by the triad of acute hypokalemia without total body potassium deficit, episodic muscle paralysis, and thyrotoxicosis. Graves' encephalopathy is an extremely rare form of encephalopathy associated with autoimmune thyroid disease (EAATD), characterized by neuropsychiatric symptoms, increased antithyroid antibodies and cerebrospinal fluid protein concentration, nonspecific electroencephalogram abnormalities, and cortico-responsiveness. Coexistence of both these complications in the same patient has not been reported before. Read More

J Med Case Rep 2017 Jun 23;11(1):173. Epub 2017 Jun 23.

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Background: Thyrotoxic crisis and pheochromocytoma multisystem crisis are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of a patient who simultaneously developed thyrotoxic crisis and pheochromocytoma multisystem crisis and required intensive cardiovascular management.

Case Presentation: A 60-year-old Asian man experienced nausea and vomiting, and subsequently developed dyspnea and cold sweats while farming. Read More

Medicine (Baltimore) 2017 Jun;96(22):e7053

aDepartment of Cardiovascular Medicine bDepartment of Therapeutic Strategy for Heart Failure cDepartment of Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Rationale: Heart failure is relatively common in patients with hyperthyroidism, but thyrotoxic cardiomyopathy with poor left ventricular (LV) systolic function is very rare.

Patient Concerns: We experienced a representative case of a patient who presented with severe LV dysfunction related to thyroid storm and needed extracorporeal membrane oxygenation (ECMO) temporally.

Diagnosis: Thyrotoxic cardiomyopathy. Read More

Clin Nucl Med 2017 Jun;42(6):475-477

From the *Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, †Nuclear Medicine, Department of Radiology, and ‡Department of Pathology, University of Michigan, Ann Arbor, MI.

We report the case of a 61-year-old woman with persistent thyrotoxicosis for 7 years despite low thyroidal radioiodine uptake and methimazole treatment. Her initial I whole-body scan (WBS) was read as negative. Upon evaluation in our institution, she remained hyperthyroid after discontinuation of methimazole. Read More

Am J Emerg Med 2017 Jul 27;35(7):1039.e5-1039.e7. Epub 2017 Feb 27.

Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

Background: Ipilimumab (a monoclonal antibody against CTLA-4) and nivolumab (a humanized antibody against PD-1) target these immune checkpoint pathways and are used for treatment of melanoma and an increasing number of other cancers. However, they may cause immune-related adverse effects (IRAEs). Although many endocrinopathies are known to be IRAEs, primary hypoparathyroidism with severe hypocalcemia has never been reported. Read More

BMJ 2017 Feb 9;356:j534. Epub 2017 Feb 9.

Mater Misericordiae Health Services Brisbane Ltd, Queensland Diabetes and Endocrine Centre, South Brisbane, Queensland, Australia