1,272 results match your criteria Thyroid Papillary Carcinoma Early


Rab22a Promotes Epithelial-Mesenchymal Transition in Papillary Thyroid Carcinoma by Activating PI3K/AKT/mTOR Signaling Pathway.

Biomed Res Int 2022 15;2022:1874550. Epub 2022 Jun 15.

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Background: Rab22a is a member of the RAS superfamily, involved in early endosome formation and intracellular vesicle transport. Rab22a is significantly upregulated in a variety of malignant tumors. However, its function in thyroid cancer has never been addressed. Read More

View Article and Full-Text PDF

Identification and Validation of a Prognostic Signature for Thyroid Cancer Based on Ferroptosis-Related Genes.

Genes (Basel) 2022 Jun 1;13(6). Epub 2022 Jun 1.

Department of Surgical Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Background: Thyroid cancer is the most common endocrine malignancy. Most PTC patients have a good prognosis; however, there are 5-20% of PTC patients with extra-thyroidal invasion, vascular invasion, or distant metastasis who have relatively poor prognoses. The aim of this study is to find new and feasible molecular pathological markers and therapeutic targets for early identification and appropriate management. Read More

View Article and Full-Text PDF

Split cord malformation concomitant with spinal teratoma without open spinal dysraphism.

Childs Nerv Syst 2022 Jun 10. Epub 2022 Jun 10.

FSM Training and Research Hospital, Neurosurgery Clinic, Istanbul, Turkey.

Purpose: Split cord malformation (SCM) presenting concomitant with spinal teratoma without any open spinal dysraphism has rarely been reported in the literature. We aimed to make a systematic review and qualitative analysis of the literature about the topic and present the first case of SCM concomitant with spinal teratoma harboring papillary thyroid carcinoma (PTC) component.

Methods: Two big search tools (Pubmed/MEDLINE) and Scopus were used. Read More

View Article and Full-Text PDF

Predictive Factors Indicative of Hemithyroidectomy and Close Follow-Up versus Bilateral Total Thyroidectomy for Aggressive Variants of Papillary Thyroid Cancer.

Cancers (Basel) 2022 Jun 2;14(11). Epub 2022 Jun 2.

Department of Surgery, College of Medicine, Severance Hospital, Yonsei University, Seoul 03722, Korea.

The diagnostic and treatment rates of early thyroid cancer have been increasing, including those of aggressive variants of papillary thyroid cancer (AVPTC). This study aimed to analyze the need for completion total thyroidectomy after lobectomy for clinically low-to-intermediate-risk AVPTC. Overall, 249 patients who underwent hemithyroidectomy (HT, n = 46) or bilateral total thyroidectomy (BTT, n = 203) for AVPTC between November 2005 and December 2019 at our single institution were examined. Read More

View Article and Full-Text PDF

The fluorescence amplification strategy based on 3D DNA walker and CRISPR/Cas12a for the rapid detection of BRAF V600E.

Anal Sci 2022 Jun 3. Epub 2022 Jun 3.

Key Laboratory of Medical Diagnostics, Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, People's Republic of China.

Circulating tumor DNA (ctDNA) is a fragment of single- or double-stranded DNA originating from tumor or circulating tumor cells and provides accurate information regarding the molecular characteristics of tumors. Therefore, sensitive detection of ctDNA is of great significance to mutation analysis and clinical diagnosis. Among various ctDNAs, the BRAF V600E is related to aggressive behavior, disease recurrence, and disease-specific mortality in papillary thyroid carcinoma. Read More

View Article and Full-Text PDF

Benign and malignant thyroid nodules with autoimmune thyroiditis.

Arch Endocrinol Metab 2022 Jun 2. Epub 2022 Jun 2.

Endocrine Unit, Alexandra General Hospital, Athens, Greece.

Objective: The prevalence of autoimmune thyroiditis (AT) in papillary thyroid carcinoma (PTC) is still controversial. The aim of this study was to investigate the frequency of coexistence of PTC with AT versus that of the coexistence of benign nodules with AT.

Materials And Methods: This was a cross-sectional retrospective study including patients operated on for thyroid nodules from January 2011, to April 2021. Read More

View Article and Full-Text PDF

Insular thyroid carcinoma in a young Moroccan man: Case report and review of the literature.

Ann Med Surg (Lond) 2022 May 6;77:103592. Epub 2022 Apr 6.

Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohammed the First University, Oujda, Morocco.

Introduction: Insular thyroid carcinoma (ITC) was defined as a rare malignant thyroid cancer standing in an intermediate position between the well-differentiated (papillary and follicular) and the anaplastic thyroid carcinomas. The incidence was estimated around <1% and 10% worldwide. Despite its rarity, it remains the main cause of death from non-anaplastic follicular cell-derived thyroid cancers. Read More

View Article and Full-Text PDF

Smartphone-Based Electrochemiluminescence for Visual Simultaneous Detection of and Tumor Suppressor Gene Methylation in Thyroid Cancer Patient Plasma.

Anal Chem 2022 Jun 26;94(22):8005-8013. Epub 2022 May 26.

Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, P.O. Box 1411713137, Islamic Republic of Iran.

Visual one-step simultaneous detection of low-abundance methylation is a crucial challenge in early cancer diagnosis in a simple manner. Through the design of a closed split bipolar electrochemistry system (BE), detection of promoter methylation of tumor suppressor genes in papillary thyroid cancer, and , was achieved using electrochemiluminescence. For this purpose, electrochemiluminescence of luminol loaded into the [email protected] and gold nanorod-functionalized graphite-like carbon nitride nanosheet ([email protected] NS), separately, on the anodic and cathodic pole bipolar electrodes (BPEs) in two different chambers of a bipolar cell were recorded on a smartphone camera. Read More

View Article and Full-Text PDF

Long-term follow-up ultrasonography surveillance in a large cohort of patients with papillary thyroid carcinoma.

Endocrine 2022 May 19. Epub 2022 May 19.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Objective: This study aimed to investigate the predictive factors as well as the time and age course of recurrence/persistence in a large cohort of postoperative patients with papillary thyroid carcinoma (PTC) based on the long-term ultrasonography (US) follow-up data.

Methods: Between January 2007 and December 2016, 3106 patients underwent surgery for PTC and at least two postoperative US follow-up examination over more than three years. Tumor recurrence/persistence was confirmed based on the follow-up US data and histopathological results. Read More

View Article and Full-Text PDF

Well-Differentiated Thyroid Cancer: Who Should Get Postoperative Radiation?

Ann Surg Oncol 2022 May 18. Epub 2022 May 18.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: The mainstay of treatment of well-differentiated thyroid cancer (WDTC) is surgery followed by adjuvant radioactive iodine therapy. Postoperative radiation therapy (PORT) is rarely used.

Objective: The aim of our study was to report our experience of patients with WDTC who were selected to receive PORT. Read More

View Article and Full-Text PDF

Mandibular metastasis of follicular thyroid carcinoma: A case report along with the concise review of literature.

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):133. Epub 2022 Mar 31.

Department of Oral Pathology, Microbiology and Forensic Odontology, Laxmi Bai Institute of Dental Sciences and Hospital, Patiala, Punjab, India.

Metastasis is one of the most common consequences of malignant tumors, and it is one of the leading causes of morbidity and mortality. Metastatic cancers to oral cavity are extremely rare. Moreover, the true incidence has yet to be determined. Read More

View Article and Full-Text PDF

Non-iodine Avid Disease is Highly Prevalent in Distant Metastatic Differentiated Thyroid Cancer with Papillary Histology.

J Clin Endocrinol Metab 2022 May 12. Epub 2022 May 12.

Division of Endocrinology, Department of Medicine, University of California, San Francisco.

Context: Patients with radioactive iodine (RAI) refractory metastatic differentiated thyroid cancer (DTC) have poor prognosis. Early identification of RAI refractoriness may improve care.

Objective: To characterize DTC patients with distant metastases (DM) at diagnosis who presented with non-iodine avid disease. Read More

View Article and Full-Text PDF

Radioactive iodine therapy: multiple faces of the same polyhedron.

Arch Endocrinol Metab 2022 May 12. Epub 2022 May 12.

Memorial Sloan Kettering Cancer Center, New York, NY, United States.

The incidence of differentiated thyroid carcinoma (DTC) has increased in recent decades with early stage, low risk papillary thyroid cancer (PTC) being detected and diagnosed. As a result, the psychological, financial, and clinical ramifications of overdiagnosis and excessively aggressive therapy are being increasingly recognized with many authorities calling for a re-evaluation of the traditional "one size fits all" management approaches. To address these critical issues, most thyroid cancer guidelines endorse a more risk adapted management strategy where the intensity of therapy and follow up is matched to the anticipated risk of recurrence and death from DTC for each patient. Read More

View Article and Full-Text PDF

Evolution of Bordetella pertussis in the acellular vaccine era in Norway, 1996 to 2019.

Eur J Clin Microbiol Infect Dis 2022 Jun 11;41(6):913-924. Epub 2022 May 11.

Norwegian Institute of Public Health, Oslo, Norway.

We described the population structure of Bordetella pertussis (B. pertussis) in Norway from 1996 to 2019 and determined if there were evolutionary shifts and whether these correlated with changes in the childhood immunization program. We selected 180 B. Read More

View Article and Full-Text PDF

Prognostic Roles of ZNF703 and SMAD4 Expression in Patients with Papillary Thyroid Cancer and Association with Nodal Metastasis.

Indian J Surg Oncol 2022 Mar 15;13(1):169-177. Epub 2022 Feb 15.

Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

It is important to detect novel predictive biomarkers of cervical lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) to help the surgeons in making early decision of performing central lymph node dissection and aggressive management strategies in selected high-risk patients, thus improving their prognosis. Zinc finger protein 703 (ZNF703) is a member of the neutrophil extracellular trap (NET) transcription factors family which has roles in proliferation and invasion of cancer cells. SMAD4 is a protein that has a role in cellular processes including cell proliferation, invasion, and metastasis through many genes' transcription. Read More

View Article and Full-Text PDF

Preoperative platelet distribution width-to-platelet ratio combined with serum thyroglobulin may be objective and popularizable indicators in predicting papillary thyroid carcinoma.

J Clin Lab Anal 2022 Jun 20;36(6):e24443. Epub 2022 Apr 20.

The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Objectives: The incidence of papillary thyroid carcinoma (PTC) has increased more rapidly than that of any other cancer type in China. Early indicators with high sensitivity and specificity during diagnosis are required. To date, there has been a paucity of studies investigating the relationship between preoperative platelet distribution width-to-platelet count ratio (PPR) and PTC. Read More

View Article and Full-Text PDF

Prognostic significance of patient age in papillary thyroid carcinoma with no high-risk features.

Endocr J 2022 Apr 15. Epub 2022 Apr 15.

Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan.

Older age is recognized as a predictor of poor prognosis in papillary thyroid carcinoma (PTC) patients. However, young age is associated with disease progression of PTC measuring 1 cm or smaller in patients on active surveillance. In this study, we investigated the relationship between patient age and prognosis of PTC belonging to very low-, low-, and intermediate-risk groups based on the guidelines published by the Japan Association of Endocrine Surgery in 2018. Read More

View Article and Full-Text PDF

Pre-existing Thyroid Autoimmunity and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study of US Active-Duty Personnel.

J Clin Oncol 2022 Apr 13:JCO2102618. Epub 2022 Apr 13.

Division of Immunology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: Thyroid autoimmunity has been associated with differentiated thyroid cancer although multiple potential biases might have influenced the results of previous studies.

Methods: We conducted a case-control study nested within the cohort of US active-duty personnel 1996-2014 to assess the association between thyroid autoimmunity, defined by serology, and thyroid cancer diagnosis. The primary exposure was thyroid peroxidase (TPO) antibody status 7-10 years before the thyroid cancer index date. Read More

View Article and Full-Text PDF

A rare case of follicular thyroid carcinoma metastasis to the sacral region: A case report with literature review.

Int J Surg Case Rep 2022 May 29;94:107001. Epub 2022 Mar 29.

ENT Head and Neck Surgery Department, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

Introduction: Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer subtype after papillary thyroid cancer (PTC), and it accounts for approximately 10% of all thyroid cancers, the incidence of distant metastasis in FTC has been reported to be 6-20%, bones and lungs are the most frequent sites of distant metastases. Most occult thyroid carcinomas are papillary carcinoma.

Case Presentation: We describe an extremely rare case of a 74-year-old woman who had a history of right thyroid lobectomy 20 years ago, was referred to our hospital for metastatic thyroid follicular carcinoma to the sacral region confirmed by the biopsy of the sacral mass. Read More

View Article and Full-Text PDF

Stress, Thyroid Dysregulation and Thyroid Cancer in Children and Adolescents. Proposed Impending Mechanisms.

Horm Res Paediatr 2022 Apr 6. Epub 2022 Apr 6.

Stress is a potential catalyst for thyroid dysregulation through cross-communication of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid (HPT) axes. Stress and stressors exposure motivates molecular mechanisms affecting compound feedback loops of the HPT axis. Whilst, there is evidence of connection between stress and thyroid dysregulation, the question whether this connection is implicated in the development of thyroid cancer (TC) remains unanswered. Read More

View Article and Full-Text PDF

The Subcellular Localization of IncRNA FAM230B in Osteosarcoma and Its Interaction with Early miR-203.

Crit Rev Eukaryot Gene Expr 2022 ;32(1):59-65

Department of Orthopaedic, The First Affiliated Clinical Hospital of Harbin Medical University, Nangang District, Harbin City, Heilongjiang Province, P.R. China.

Previous studies have revealed the role of lncRNA FAM230B in promoting papillary thyroid cancer and gastric cancer. We predicted that FAM230B may interact with miR-203 and studied the crosstalk between FAM230B and miR-203 in osteosarcoma (OS). Paired OS and nontumor tissues donated by 60 patients with OS were subjected to RNA isolations and quantitative real-time PCR (RT-qPCR) to analyze the expression of both FAM230B and miR-203 (mature and premature levels). Read More

View Article and Full-Text PDF

Machine learning on thyroid disease: a review.

Front Biosci (Landmark Ed) 2022 03;27(3):101

Department of Obstetrics & Gynecology, Korea University College of Medicine, 02841 Seoul, Republic of Korea.

This study reviews the recent progress of machine learning for the early diagnosis of thyroid disease. Based on the results of this review, different machine learning methods would be appropriate for different types of data for the early diagnosis of thyroid disease: (1) the random forest and gradient boosting in the case of numeric data; (2) the random forest in the case of genomic data; (3) the random forest and the ensemble in the case of radiomic data; and (4) the random forest in the case of ultrasound data. Their performance measures varied within 64. Read More

View Article and Full-Text PDF

APOBEC SBS13 Mutational Signature-A Novel Predictor of Radioactive Iodine Refractory Papillary Thyroid Carcinoma.

Cancers (Basel) 2022 Mar 21;14(6). Epub 2022 Mar 21.

Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Standard surgery followed by radioactive iodine (I, RAI) therapy are not curative for 5-20% of papillary thyroid carcinoma (PTC) patients with RAI refractory disease. Early predictors indicating therapeutic response to RAI therapy in PTC are yet to be elucidated. Whole-exome sequencing was performed (at median depth 198x) on 66 RAI-refractory and 92 RAI-avid PTCs with patient-matched germline. Read More

View Article and Full-Text PDF

Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022: DICER1-Related Thyroid Tumors.

Head Neck Pathol 2022 Mar 21;16(1):190-199. Epub 2022 Mar 21.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

DICER1 syndrome is an autosomal dominant tumor predisposition syndrome caused by germline DICER1 mutations. In the thyroid, DICER1 syndrome is associated with early-onset multinodular goiter and thyroid carcinomas. Subsequent studies have shown that somatic DICER1 mutations, though rare, can occur in follicular-patterned thyroid tumors, such as follicular adenomas and follicular thyroid carcinomas, with a higher rate seen in pediatric follicular thyroid carcinomas and in follicular thyroid carcinomas with a macrofollicular architecture. Read More

View Article and Full-Text PDF

Phase II multicohort study of atezolizumab monotherapy in multiple advanced solid cancers.

ESMO Open 2022 04 16;7(2):100419. Epub 2022 Mar 16.

Centre of Applied Medical Research, University Clinic of Navarra, Navarra, Spain.

Background: The programmed death-ligand 1 inhibitor atezolizumab had shown clinical activity against several advanced malignancies.

Patients And Methods: This phase II, open-label basket study (NCT02458638) was conducted in 16 main cohorts of patients aged ≥18 years with stage III or IV solid tumors. In stage I, 12 patients were enrolled into each cohort. Read More

View Article and Full-Text PDF

Papillary thyroid cancer: the value of bilateral diagnostic lymphadenectomy.

Langenbecks Arch Surg 2022 Mar 17. Epub 2022 Mar 17.

Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: Papillary thyroid carcinoma (PTC) spreads early to lymph nodes (LN). However, prophylactic central (CND) and lateral neck dissection (LND) is controversially discussed in patients with clinically negative nodes (cN0). The preoperative prediction of LN metastasis is desirable as re-operation is associated with higher morbidity and poor prognosis. Read More

View Article and Full-Text PDF

Emerging Role of Oxidative Stress on EGFR and OGG1-BER Cross-Regulation: Implications in Thyroid Physiopathology.

Cells 2022 02 26;11(5). Epub 2022 Feb 26.

Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.

Thyroid diseases have a complex and multifactorial aetiology. Despite the numerous studies on the signals referable to the malignant transition, the molecular mechanisms concerning the role of oxidative stress remain elusive. Based on its strong oxidative power, HO could be responsible for the high level of oxidative DNA damage observed in cancerous thyroid tissue and hyperactivation of mitogen-activated protein kinase (MAPK) and PI3K/Akt, which mediate ErbB signaling. Read More

View Article and Full-Text PDF
February 2022

[Detection of DNA methylation of gene for differentiating malignant from benign thyroid tumors].

Nan Fang Yi Ke Da Xue Xue Bao 2022 Jan;42(1):123-129

School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Objective: To assess the value of DNA methylation level of gene as a molecular marker for differential diagnosis of malignant and benign thyroid tumors.

Methods: DNA methylation of gene in tissue specimens of 190 patients with papillary thyroid cancer (PTC) and 190 age- and gender-matched patients with benign thyroid tumors was examined by mass spectrometry, and the protein expression of HYAL2 was detected immunohistochemically for another 55 pairs of patients. Logistic regression analysis was performed to calculate the odds ratio (OR) and evaluate the correlation of per 10% reduction in DNA methylation with PTC. Read More

View Article and Full-Text PDF
January 2022

Resistance to RET targeted therapy in Thyroid Cancer: Molecular basis and overcoming strategies.

Cancer Treat Rev 2022 Apr 1;105:102372. Epub 2022 Mar 1.

Medical Oncology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain; The Ramon y Cajal Health Research Institute [IRYCIS], CIBERONC, 28034 Madrid, Spain; Medicine School, Alcalá University, 28805 Madrid, Spain. Electronic address:

Thyroid cancer is the most frequently diagnosed endocrine malignancy, with an increasing incidence over the last decades. The recent advances in understanding the molecular mechanisms underlying the carcinogenesis of thyroid cancer have led to a better therapeutic approach of these tumors. This has allowed the development and approval of several drugs during the past decade. Read More

View Article and Full-Text PDF

Targeting Diagnosis of High-Risk Papillary Thyroid Carcinoma Using Ultrasound Contrast Agent With the BRAF Mutation: An Experimental Study.

J Ultrasound Med 2022 Mar 1. Epub 2022 Mar 1.

Department of Ultrasound, The First Medical Center of PLA General Hospital, Beijing, China.

Objective: High-risk papillary thyroid carcinoma (PTC) patients with BRAF mutation have lymph node and distant metastasis and poor prognosis. Therefore, this study aims to develop a targeted ultrasound contrast agent for the BRAF mutation to screen high-risk PTC at early stage.

Methods: The targeted lipid nanobubbles carrying BRAF antibody were prepared using thin film hydration-sonication and avidin-biotin binding methods. Read More

View Article and Full-Text PDF