1,092 results match your criteria Thyroid Papillary Carcinoma Early


A Novel Combination of Metachronous Primary Malignancies of the Thyroid and Breast in a Patient with Neurofibromatosis Type 1.

Cureus 2020 Apr 8;12(4):e7590. Epub 2020 Apr 8.

Hematology and Oncology, Creighton University Maricopa Medical Center, Phoenix, USA.

Neurofibromatosis 1 (NF1) is a genetic condition of variable presentations. It has been shown to increase the risk of multiple cancers. Therefore, NF1 has been identified as a tumor-provoking condition. Read More

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http://dx.doi.org/10.7759/cureus.7590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212712PMC

Racial Disparities in Cancer Presentation and Outcomes: The Contribution of Overdiagnosis.

JNCI Cancer Spectr 2020 Apr 6;4(2):pkaa001. Epub 2020 Apr 6.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Racial disparities in cancer have been attributed to population differences in access to care. Differences in cancer overdiagnosis rates are another, less commonly considered cause of disparities. Here, we examine the contribution of overdiagnosis to observed racial disparities in papillary thyroid cancer and estrogen/progesterone receptor positive (ER/PR+) breast cancer. Read More

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http://dx.doi.org/10.1093/jncics/pkaa001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190210PMC

Hurthle Cell Adenoma with Micro-Papillary Carcinoma and Parathyroid Adenoma in a Transplant Recipient with Graft Failure: A Case Report.

Gulf J Oncolog 2020 Jan;1(32):66-70

Kuwait Cancer Control Center, Kuwait.

Chronic immunosuppression is known to cause an increased risk of cancers in organ transplant recipients leading to the rise in morbidity and mortality among these patients. Recent studies have observed that thyroid lesions are more frequently encountered in kidney transplant recipients. A 45-year-old woman with history of chronic hypertension, kidney transplant and graft failure, was admitted for assessment for a second renal transplant and detected to have a thyroid nodule by ultrasound (US). Read More

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January 2020

The impact of radioactive iodine treatment on survival among papillary thyroid cancer patients according to the 7th and 8th editions of the AJCC/TNM staging system: a SEER-based study.

Updates Surg 2020 Apr 27. Epub 2020 Apr 27.

Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin, 300052, People's Republic of China.

Papillary thyroid cancer is a very common endocrine malignancy. The 8th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system introduced major changes. We conducted this retrospective cohort analysis to assess the benefits of radioactive iodine (RAI) according to different stratification of patients. Read More

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http://dx.doi.org/10.1007/s13304-020-00773-yDOI Listing

[Modern thyroid surgery - the surgeon's endocrine-surgical understanding and his responsibility for the extent of surgery and complication rate].

Wien Med Wochenschr 2020 Apr 27. Epub 2020 Apr 27.

Chirurgie, Sanatorium Kettenbrücke der Barmherzigen Schwestern, Sennstraße 1, 6020, Innsbruck, Österreich.

High quality thyroid surgery implies a surgeon with an endocrine-surgical understanding aiming at best possible outcome. This includes an appropriate extent of the resection and a low rate of complications. It is important that the surgeon is involved at an early stage being part of the decision process for or against partial or total thyroidectomy. Read More

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http://dx.doi.org/10.1007/s10354-020-00750-5DOI Listing

Expression based biomarkers and models to classify early and late-stage samples of Papillary Thyroid Carcinoma.

PLoS One 2020 23;15(4):e0231629. Epub 2020 Apr 23.

Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India.

Introduction: Recently, the rise in the incidences of thyroid cancer worldwide renders it to be the sixth most common cancer among women. Commonly, Fine Needle Aspiration biopsy predominantly facilitates the diagnosis of the nature of thyroid nodules. However, it is inconsiderable in determining the tumor's state, i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231629PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179925PMC
April 2020
3.234 Impact Factor

Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.

Int J Oncol 2020 May 25;56(5):1284-1293. Epub 2020 Feb 25.

Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Ribosomal S6 kinase 4 (RSK4) is a putative tumor suppressor gene which is inactivated by epigenetic events in a number human malignancies; however, its role in papillary thyroid carcinoma (PTC) remains largely unknown. The aim of this study was to explore the methylation status of the RSK4 promoter in PTC, and to determine its potential role in thyroid carcinogenesis. Reverse transcription‑quantitative PCR (RT‑qPCR) and western blot analyses were performed to examine the RSK4 mRNA and protein levels, respectively. Read More

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http://dx.doi.org/10.3892/ijo.2020.4999DOI Listing

[Clinical pathology and incidence trend of thyroid cancer based on 21 980 cases].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(14):1072-1076

Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Key-Discipline Laboratory Clinical Medicine for Colleges and Universities in Henan, Zhengzhou 450052, China.

To analyze the clinical pathological characteristics and incidence of thyroid cancer. The clinical and pathological data of 21 980 thyroid cancer patients who underwent surgery in the Department of Thyroid Surgery of the First Affiliated Hospital of Zhengzhou University from January 2012 to December 2018, including the gender, age, pathological type, tumor size, tumor number, central and lateral lymph node metastasis, was retrospectively analyzed. There were 16 895 females and 5 085 males (gender ratio: 3. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190905-01972DOI Listing

Acceleration of BRAF-induced thyroid carcinogenesis by TGFβ signal deficiency in mice.

Endocrine 2020 Apr 12. Epub 2020 Apr 12.

Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Purpose: Transforming growth factor-β (TGFβ) has pleiotropic actions, including both anti- and pro-tumorigenic abilities. We have previously shown no tumor development in the thyroid-specific TGFβ receptor type II knockout (Tgfβr2 KO) mice, indicating the insufficiency of defective TGFβ signal itself for thyroid cancer initiation. In the current study, we evaluated whether defective TGFβ signal accelerates BRAF-mediated thyroid carcinogenesis in our mouse model, in which intrathyroidal injection of adenovirus expressing Cre under thyroglobulin (TG) promoter (Ad-TgP-Cre) into thyroid lobes of conditional Braf knock-in mice (Braf) induces thyroid cancers 12 months later. Read More

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http://dx.doi.org/10.1007/s12020-020-02298-1DOI Listing

Cystic Lateral Lymph Node Metastases From Papillary Thyroid Cancer Patients.

Laryngoscope 2020 Apr 10. Epub 2020 Apr 10.

Department of Surgery, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.

Objectives/hypothesis: Papillary thyroid carcinoma (PTC) tends to metastasize rather early to local lymph nodes (LNs). Incidences of cystic LN metastases is relatively rare compared with that of solid LN metastases. Few studies have attempted to assess the characteristics in these patients. Read More

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http://dx.doi.org/10.1002/lary.28631DOI Listing

Adult Ectopic Cervical Thymic Tissue in relation to a Parathyroid Adenoma and a Papillary Thyroid Carcinoma: A Report of Two Cases.

Case Rep Otolaryngol 2020 11;2020:9127635. Epub 2020 Mar 11.

Department of Otolaryngology, Maharishi Markandeshwar Institute of Medical Sciences and Research, MMDU, Mullana, Ambala, Haryana, India.

Ectopic cervical thymus is a rare congenital anomaly, which results because of the failure of complete descent of the thymus. They are incidental findings in the young and may disappear during the early years of life; however, they have rarely been described in adults. Some of them may undergo hyperplasia or neoplastic transformation and become visible or cause symptoms. Read More

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http://dx.doi.org/10.1155/2020/9127635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086421PMC

Long-term therapeutic outcomes of papillary thyroid carcinoma with concomitant hyperparathyroidism: A single center case-control study.

Biomed J 2020 Feb 27;43(1):53-61. Epub 2020 Feb 27.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Papillary thyroid carcinoma occasionally presents with concomitant hyperparathyroidism; however, the clinical significance has not been well established. This study aimed to evaluate the long-term cancer prognosis following a multimodality therapy.

Methods: We conducted a case-control study using prospectively maintained data from a medical center thyroid cancer database between 1980 and 2013. Read More

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http://dx.doi.org/10.1016/j.bj.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090315PMC
February 2020

The Impact of Arterial Phase on the Detection of Cervical Lymph Node Metastasis From Papillary Thyroid Carcinoma: A Quantitative Evaluation on Multiphasic Computed Tomography.

J Comput Assist Tomogr 2020 Mar/Apr;44(2):262-268

Otorhinolaringology, School of Medicine, Ankara University, Ankara, Turkey.

Objective: The purpose of this study was to assess the diagnostic performance of multiphasic computed tomography (CT) in the discrimination of metastatic lymph nodes (LNs) of papillary thyroid cancer by using quantitative parameters.

Methods: This study enrolled 272 pathologically proven metastatic and benign LNs. Multiphasic CT was utilized by using nonenhanced, arterial (25-second delay), and venous (80-second delay) phases. Read More

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http://dx.doi.org/10.1097/RCT.0000000000001005DOI Listing

[Mutation of RAS gene in follicular-differentiated thyroid tumors and its significance].

Zhonghua Bing Li Xue Za Zhi 2020 Mar;49(3):256-261

Department of Pathology, Shunyi Region Hospital of Beijing, Beijing 101300, China.

To investigate the frequency and clinical significance of RAS mutation in thyroid tumors with follicular differentiation. The samples and clinical data of 207 patients with thyroid follicular-differentiated tumors were collected at Shunyi Region Hospital of Beijing from January 2000 to December 2017, including 60 cases of follicular variant of papillary thyroid carcinoma (FVPTC), 42 cases of classical papillary thyroid carcinoma (CPTC), 26 cases of follicular thyroid carcinoma (FTC), 40 cases of follicular adenoma (FTA) and 39 cases of adenomatoid hyperplasia. BRAF V600E mutations were detected using immunohistochemical staining. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.03.007DOI Listing

Thyroid carcinoma with atypical metastasis to the pituitary gland and unexpected postmortal diagnosis.

Endocrinol Diabetes Metab Case Rep 2020 Mar 13;2020. Epub 2020 Mar 13.

Departments of Endocrinology, Diabetology and Internal Medicine.

Summary: Papillary thyroid gland carcinoma is the most common type of malignancy of the endocrine system. Metastases to the pituitary gland have been described as a complication of papillary thyroid cancer in few reported cases since 1965. We report the case of a 68-year-old female patient with a well-differentiated form of thyroid gland cancer. Read More

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http://dx.doi.org/10.1530/EDM-19-0148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077587PMC

Identification of potential novel biomarkers to differentiate malignant thyroid nodules with cytological indeterminate.

BMC Cancer 2020 Mar 12;20(1):199. Epub 2020 Mar 12.

Institute of Life Sciences, Jiangsu University, 301 Xuefu Road, JinKou District, Zhenjiang, 212013, PR China.

Background: The fine-needle aspiration (FNA) biopsy was broadly applied to clinical diagnostics evaluation for thyroid carcinomas nodule, while companioning with higher uncertainty rate (15~30%) to identify malignancy for cytological indeterminate cases. It is requirement to discover novel molecular biomarkers to differentiate malignant thyroid nodule more precise.

Methods: We employed weighted gene co-expression network analysis (WGCNA) to discover genes significantly associated with malignant histopathology for cytological indeterminate nodules. Read More

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http://dx.doi.org/10.1186/s12885-020-6676-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066786PMC

Bilateral central neck dissection in the treatment of early unifocal papillary thyroid carcinomas with poor risk factors A mono-institutional experience.

Ann Ital Chir 2019 Dec 20;8. Epub 2019 Dec 20.

Introduction: Papillary thyroid carcinoma is the most common type of thyroid cancer worldwide. While total thyroidectomy is widely considered the standard surgical approach for papillary thyroid carcinomas, the role of central lymphadenectomy in early stage poor-risk papillary thyroid tumors is still a matter of debate. This study was designed to assess surgical complications and local disease control rates in patients affected by poor-risk early stage papillary thyroid carcinomas. Read More

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December 2019

Radiation-Associated Secondary Malignancies in BRCA Mutation Carriers Treated for Breast Cancer.

Int J Radiat Oncol Biol Phys 2020 Jun 19;107(2):353-359. Epub 2020 Feb 19.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Radiation Oncology Department, Chaim Sheba Medical Center, Ramat-Gan, Israel. Electronic address:

Purpose: Radiation therapy (RT), a standard breast cancer (BC) treatment modality, is associated with a small increased risk of in-field second primary malignancy (SPM). SPM rates after RT in BRCA mutation carriers have rarely been reported. An elevated risk of SPM would affect the safety of breast conservation for early BC or prophylactic radiation as a method of prevention. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.02.020DOI Listing

State-of-the-Art Strategies for Targeting -Dependent Cancers.

J Clin Oncol 2020 Apr 21;38(11):1209-1221. Epub 2020 Feb 21.

Department of Investigational Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.

Activating receptor tyrosine kinase RET (rarranged during transfection) gene alterations have been identified as oncogenic in multiple malignancies. RET gene rearrangements retaining the kinase domain are oncogenic drivers in papillary thyroid cancer, non-small-cell lung cancer, and multiple other cancers. Activating RET mutations are associated with different phenotypes of multiple endocrine neoplasia type 2 as well as sporadic medullary thyroid cancer. Read More

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http://dx.doi.org/10.1200/JCO.19.02551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145587PMC

Mapping the Molecular Basis and Markers of Papillary Thyroid Carcinoma Progression and Metastasis Using Global Transcriptome and microRNA Profiling.

OMICS 2020 Mar 19;24(3):148-159. Epub 2020 Feb 19.

Department of Pathology, School of Medicine, Kocaeli University, Kocaeli, Turkey.

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer (TC). In a subgroup of patients with PTC, the disease progresses to an invasive stage or in some cases to distant organ metastasis. At present, there is an unmet clinical and diagnostic need for early identification of patients with PTC who are at risk of disease progression or metastasis. Read More

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http://dx.doi.org/10.1089/omi.2019.0188DOI Listing

BIRC7 promotes epithelial-mesenchymal transition and metastasis in papillary thyroid carcinoma through restraining autophagy.

Am J Cancer Res 2020 1;10(1):78-94. Epub 2020 Jan 1.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.

Papillary thyroid carcinoma (PTC) is the most common cancer of the endocrine system, which is usually associated with a favorable therapeutic response and prognosis. However, metastatic spreading occurs in around 5% of the PTC patients. Identification of molecular markers could early predict the metastatic potential, which is essential for reducing the patient's overtreatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017743PMC
January 2020

Exon 15 Mutations in Papillary Carcinoma and Adjacent Thyroid Parenchyma: A Search for the Early Molecular Events Associated with Tumor Development.

Cancers (Basel) 2020 Feb 12;12(2). Epub 2020 Feb 12.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna-Molecular Diagnostic Unit, Azienda USL di Bologna, 40138 Bologna, Italy.

exon 15 mutations are the most common molecular alterations found in papillary thyroid carcinoma (PTC). To date, there is no information regarding alterations in the thyroid parenchyma surrounding the tumor. To explore the early events associated with the development of PTC, we used massively parallel sequencing to investigate exon 15 in 30 PTCs and in 100 samples from the thyroid parenchyma surrounding the tumor. Read More

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http://dx.doi.org/10.3390/cancers12020430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072486PMC
February 2020

Markers of immune activation: novel biomarkers to predict the early-warning indicator of patients with papillary thyroid carcinoma.

Diagn Pathol 2020 Feb 12;15(1):16. Epub 2020 Feb 12.

Department of Central Laboratory, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, People's Republic of China.

Background: Papillary thyroid carcinoma (PTC) is an indolent tumor that is exploding with increasing thyroid nodules (TN). Environmental carcinogens, lifestyle changes increased the incidence of thyroid carcinoma. With the development of B-ultrasound imaging, more and more thyroid cancer has been found. Read More

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http://dx.doi.org/10.1186/s13000-020-00931-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017425PMC
February 2020
2.411 Impact Factor

Intratumoral Genetic Heterogeneity in Papillary Thyroid Cancer: Occurrence and Clinical Significance.

Cancers (Basel) 2020 Feb 7;12(2). Epub 2020 Feb 7.

Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.

Intratumoral heterogeneity (ITH refers to a subclonal genetic diversity observed within a tumor. ITH is the consequence of genetic instability and accumulation of genetic alterations, two mechanisms involved in the progression from an early tumor stage to a more aggressive cancer. While this process is widely accepted, the ITH of early stage papillary thyroid carcinoma (PTC) is debated. Read More

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http://dx.doi.org/10.3390/cancers12020383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072350PMC
February 2020

Recurrence following hemithyroidectomy in patients with low- and intermediate-risk papillary thyroid carcinoma.

Br J Surg 2020 May 5;107(6):687-694. Epub 2020 Feb 5.

Department of Otolaryngology - Head and Neck Surgery, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Korea.

Background: This study evaluated the incidence, patterns and risk factors for recurrence after hemithyroidectomy in patients with low- and intermediate-risk papillary thyroid carcinoma (PTC), and verified the predictive role of the risk staging systems in current use.

Methods: The clinicopathological characteristics and risk categories were analysed according to recurrence in patients who underwent hemithyroidectomy for low- and intermediate-risk conventional PTC, and were followed up for at least 24 months. Five risk staging systems were used to stratify risk: the 2015 American Thyroid Association (ATA) system; Age, Metastases, Extent and Size (AMES) system; Metastases, Age, Complete resection, Invasion and Size (MACIS) system; Grade, Age, Metastases, Extent and Size (GAMES) system; and the eighth AJCC system. Read More

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http://dx.doi.org/10.1002/bjs.11430DOI Listing

Preparation and SPECT/CT Imaging of Lu-Labeled Peptide Nucleic Acid (PNA) Targeting CITED1: Therapeutic Evaluation in Tumor-Bearing Nude Mice.

Onco Targets Ther 2020 15;13:487-496. Epub 2020 Jan 15.

Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Purpose: The expression of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (CITED1) is upregulated in papillary thyroid carcinoma (PTC) and mediates cell proliferation and migration. To facilitate early diagnosis and monitoring of recurrent or metastatic PTC, we designed Lu-labeled antisense peptide nucleic acid (PNA) targeting CITED1 mRNA to evaluate the therapeutic potential, while analyzing its distribution in nude mice and the characteristics withsingle-photon emission-computed tomography/computed tomography (SPECT/CT) imaging.

Materials And Methods: Lu-DOTA-anti-CITED1-PNA (Lu-asPNA) was obtained by indirect labeling. Read More

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http://dx.doi.org/10.2147/OTT.S238098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970276PMC
January 2020
1.342 Impact Factor

An Animal Model Further Uncovers the Role of Mutant Braf during Papillary Thyroid Cancer Development.

Am J Pathol 2020 03 14;190(3):702-710. Epub 2020 Jan 14.

Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. Electronic address:

Papillary thyroid carcinomas (PTCs) account for 90% of human thyroid cancer cases, which represent 1% of all cancer cases. They are likely to develop from papillary thyroid microcarcinomas (PTMCs), found in up to 36% of healthy individuals, due to rare progression events (0.01%). Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.11.006DOI Listing

Active Surveillance of Papillary Thyroid Microcarcinoma: Where Do We Stand?

Eur Thyroid J 2019 Dec 25;8(6):298-306. Epub 2019 Sep 25.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

The recent sharp increase in thyroid cancer incidence is mainly due to increased detection of small papillary thyroid microcarcinoma (PTMC). Due to the indolent nature of the disease, active surveillance (AS) of low-risk PTMCs is suggested as an alternative to immediate surgery to reduce morbidity from surgery. For appropriately selected PTMC patients, AS can be a good management option and surgical intervention can be safely delayed until progression occurs. Read More

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http://dx.doi.org/10.1159/000503064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944910PMC
December 2019

Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice.

J Surg Res 2020 May 7;249:58-66. Epub 2020 Jan 7.

Department of Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address:

Background: Treatment approaches for pediatric papillary thyroid cancer (PTC) are historically extrapolated from adult experience. However, pediatric PTC demonstrates a greater propensity for lymph node involvement, early metastases, and recurrence, highlighting the need for pediatric-specific treatment paradigms.

Materials And Methods: A retrospective review included patients with PTC aged ≤21 y, with ≥18 mo of follow-up, treated between 2002 and 2015. Read More

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http://dx.doi.org/10.1016/j.jss.2019.12.002DOI Listing

Silencing of PPM1D inhibits cell proliferation and invasion through the p38 MAPK and p53 signaling pathway in papillary thyroid carcinoma.

Oncol Rep 2020 Mar 9;43(3):783-794. Epub 2020 Jan 9.

Department of Head and Neck Surgery, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.

Endeavors towards identifying key molecular markers for early diagnosis and treatment are driving the clinical study of papillary thyroid carcinoma (PTC). Recent studies have indicated that protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) exerts an oncogenic function by increasing cell proliferation, migration and invasion in various cancer types. In addition, PPM1D has a high frequency of genetic alterations and has been proposed as a tumor driver in thyroid cancer, making PPM1D an attractive potential oncotarget for cancer treatment. Read More

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http://dx.doi.org/10.3892/or.2020.7458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040886PMC

Sellar surprises: a single-centre experience of unusual sellar masses.

Endocr Connect 2020 Feb;9(2):111-121

Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India.

Background: Most common incidentally detected sellar-suprasellar region (SSR) masses are pituitary adenomas, followed by craniopharyngioma, rathke's cleft cyst, hypophysitis, and meningioma. Besides these, certain unusual SSR lesions can sometimes present as diagnostic challenges, where diagnosis is often made post-operatively on histopathology, the pre-operative suspicion of which might have influenced the management strategies. Series describing such masses are few. Read More

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http://dx.doi.org/10.1530/EC-19-0497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993267PMC
February 2020

Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma - Case report and literature review.

Auris Nasus Larynx 2019 Dec 31. Epub 2019 Dec 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan. Electronic address:

Silicosis is caused by inhalation of silica dust and is the most common type of pneumoconiosis. The characteristics of silicosis are inflammation of lung tissue and calcified lymphadenopathy of pulmonary hilum, mediastinum and paratrachea. We present a papillary thyroid carcinoma (PTC) case with paratracheal and superior mediastinal calcified lymphadenopathy caused by silicosis. Read More

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http://dx.doi.org/10.1016/j.anl.2019.12.003DOI Listing
December 2019

Micro-FTIR spectroscopy as robust tool for psammoma bodies detection in papillary thyroid carcinoma.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Mar 24;229:117984. Epub 2019 Dec 24.

Department of Engineering, Roma Tre University, via Vito Volterra 62, Roma, Italy. Electronic address:

The presence of psammoma bodies (PBs), concentric lamellated calcified structures, in thyroid tissues is considered a reliable diagnostic marker for Papillary thyroid carcinoma (PTC) and has been correlated to aggressive tumour behaviours such as multifocality and lymph node metastasis. Fourier transform infrared (FTIR) microspectroscopy already proved to be a powerful tool for biological tissues study thanks to its ability to spatially resolve information on the chemical composition of the analysed samples. FTIR maps were collected from thyroid tumour resections and analysed by multivariate unsupervised Principal Component Analysis (PCA) and Clustering (K-means and fuzzy c-means clustering) techniques. Read More

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http://dx.doi.org/10.1016/j.saa.2019.117984DOI Listing

Integrated analysis identifies DUSP5 as a novel prognostic indicator for thyroid follicular carcinoma.

Thorac Cancer 2020 Feb 10;11(2):336-345. Epub 2019 Dec 10.

Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, China.

Background: Differentiated thyroid cancer involves thyroid follicular carcinoma (FTC) and papillary thyroid carcinoma (PTC). Patients with FTC have a worse prognosis than those with PTC for early metastasis through blood of FTC. However, the mechanism of poor prognosis of FTC is still unclear. Read More

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http://dx.doi.org/10.1111/1759-7714.13270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996982PMC
February 2020

Occult papillary thyroid carcinoma with cystic nodal metastasis mimicking a thyroglossal duct cyst: A case report.

Int J Surg Case Rep 2020 27;66:76-79. Epub 2019 Nov 27.

Gladstone Hospital, Park Street, Gladstone, QLD, 4680, Australia(1).

Introduction: The approach to the anterior neck lump involves the consideration of numerous benign and malignant differentials.

Presentation Of Case: We present a rare case of an occult papillary thyroid cancer with cystic nodal metastases presenting as a thyroglossal duct cyst.

Discussion: We explore the literature surrounding occult papillary thyroid carcinoma/microcarcinomas and the potential for the disease to present as a cervical lump. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911979PMC
November 2019

DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis.

J Clin Invest 2020 Mar;130(3):1479-1490

Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada.

BACKGROUNDDICER1 is the only miRNA biogenesis component associated with an inherited tumor syndrome, featuring multinodular goiter (MNG) and rare pediatric-onset lesions. Other susceptibility genes for familial forms of MNG likely exist.METHODSWhole-exome sequencing of a kindred with early-onset MNG and schwannomatosis was followed by investigation of germline pathogenic variants that fully segregated with the disease. Read More

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http://dx.doi.org/10.1172/JCI130206DOI Listing
March 2020
13.215 Impact Factor

Metastatic thyroid carcinoma presented as a large craniofacial mass: Case report and CT findings.

Radiol Case Rep 2020 Feb 23;15(2):128-132. Epub 2019 Nov 23.

Radiodiagnostic and Medical Imaging Department of Treichville Hospital and University Center, Abidjan, Côte d'Ivoire.

Cranial metastases are uncommon locations of thyroid papillary carcinoma. They significantly reduce patients' survival, especially in a context of late management. We report the case of a 46-year-old woman who presented an anterior cervical swelling, then a progressive large craniofacial mass for more than 5 years without any treatment. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881619PMC
February 2020

A novel RNA sequencing-based risk score model to predict papillary thyroid carcinoma recurrence.

Clin Exp Metastasis 2020 Apr 2;37(2):257-267. Epub 2019 Dec 2.

Department of General Surgery, Shengjing Hospital of China Medical University, No. 39 Huaxiang Street, Tiexi District, Shenyang, 110000, Liaoning Province, People's Republic of China.

The papillary thyroid carcinoma (PTC) usually shows an excellent prognosis. But some patients suffer recurrence after treatment. Recent progress in RNA sequencing (RNA-Seq) allows us to explore whole-transcriptomic gene expression profiles to develop RNA-seq based predictive model for stratifying the risk of recurrence of PTC. Read More

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http://dx.doi.org/10.1007/s10585-019-10011-4DOI Listing

Concomitant medullary thyroid carcinoma with paraganglioma-like pattern and papillary thyroid carcinoma.

Endocrinol Diabetes Metab Case Rep 2019 Nov 28;2019. Epub 2019 Nov 28.

Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, Modena, Italy.

Summary: A 74-year-old man was referred to the Endocrinology Unit because of multinodular goiter. The dominant nodule (1.7 × 1. Read More

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http://dx.doi.org/10.1530/EDM-19-0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893314PMC
November 2019

Diagnostic values of thyroglobulin in lymph node fine-needle aspiration washout: a systematic review and meta-analysis diagnostic values of FNA-Tg.

Endocr J 2020 Feb 14;67(2):113-123. Epub 2019 Nov 14.

Department of Neurosurgeon, Zhejiang Cancer Hospital, Hangzhou 310022, People's Republic of China.

Thyroglobulin measurement in the needle washout after fine-needle aspiration (FNA-Tg) served as an important measurement for suspicious recurrent or metastatic lesions. We conducted a pooled analysis to evaluate the diagnostic accuracy of FNA-Tg and searched electronic databases for original articles in English from 1993 through 2017. Finally, a total of 22 studies containing 2,670 lymph nodes (LNs) that enrolled participants with suspicious neck LNs during thyroid nodule workup or papillary thyroid cancer (PTC) follow-up were included. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0558DOI Listing
February 2020

A novel gene panel for prediction of lymph-node metastasis and recurrence in patients with thyroid cancer.

Surgery 2020 01 9;167(1):73-79. Epub 2019 Nov 9.

Department of Surgery, Division of General, Endocrine and Oncological Surgery, Tulane University School of Medicine, New Orleans, LA. Electronic address:

Background: Although well-differentiated papillary thyroid cancer may remain indolent, lymph node metastases and the recurrence rates are approximately 50% and 20%, respectively. No current biomarkers are able to predict metastatic lymphadenopathy and recurrence in early stage papillary thyroid cancer. Hence, identifying prognostic biomarkers predicting cervical lymph-node metastases would prove very helpful in determining treatment. Read More

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http://dx.doi.org/10.1016/j.surg.2019.06.058DOI Listing
January 2020

[Individualization of the surgical procedure in response to overdiagnosis and overtreatment in differentiated thyroid carcinomas].

Pathologe 2019 Dec;40(Suppl 3):342-346

Sektion Endokrine Chirurgie, Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsmedizin Mainz, Johannes Gutenberg-Universität Mainz, Langenbeckstraße 1, 55131, Mainz, Deutschland.

Background: Advances in diagnostic methods have led to an early detection of thyroid nodules with debatable malignant potential in numerous cases. This can result in a potential overtreatment of thyroid lesions with very good prognosis.

Objectives: To avoid surgical overtreatment, an individualized, risk-adapted management is required that respects the different tumor biology of the underlying histological entities. Read More

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http://dx.doi.org/10.1007/s00292-019-00699-2DOI Listing
December 2019

LncRNA PTCSC3 Is a Biomarker for the Treatment and Prognosis of Gastric Cancer.

Cancer Biother Radiopharm 2020 Feb 8;35(1):77-81. Epub 2019 Nov 8.

Department of Oncology, Daqing Oilfield General Hospital, Daqing, Heilongjiang, P.R. China.

Long noncoding RNA (lncRNA) papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits several types of cancer, whereas its role in gastric cancer is unknown. From May 2010 to May 2015, this study included 68 (36 males and 32 females, 35-69 years, 48.3 ± 7. Read More

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http://dx.doi.org/10.1089/cbr.2019.2991DOI Listing
February 2020

Predictive role of intraoperative clinicopathological features of the central compartment in estimating lymph nodes metastasis status.

Ann Transl Med 2019 Sep;7(18):471

Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu 610000, China.

Background: To explore the feasibility of immediate assessment, which focuses on clinicopathological characteristics of central lymph nodes (LNs) during operation. Moreover, to analyze the predictive effect of various evaluated indicators on the nature, quantities, and ratios of central lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC), to provide the basis for precise individualized central lymph node dissection (LND).

Methods: According to the inclusion and exclusion criteria, 1,271 PTC patients were selected in this cohort study. Read More

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http://dx.doi.org/10.21037/atm.2019.08.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803219PMC
September 2019

Risks of Hypoparathyroidism After Total Thyroidectomy in Children: A 21-Year Experience in a High-Volume Cancer Center.

World J Surg 2020 Feb;44(2):442-451

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1484, Houston, TX, 77030-4095, USA.

Background: Hypoparathyroidism occurs relatively frequently after thyroid surgery in children. However, few studies have reported risk factors. We aimed to identify risk factors for hypoparathyroidism that occurred after total thyroidectomy for proven or suspected malignancy in children. Read More

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http://dx.doi.org/10.1007/s00268-019-05231-4DOI Listing
February 2020

Evolution and Impact of Subclonal Mutations in Papillary Thyroid Cancer.

Am J Hum Genet 2019 11 24;105(5):959-973. Epub 2019 Oct 24.

Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia. Electronic address:

Unlike many cancers, the pattern of tumor evolution in papillary thyroid cancer (PTC) and its potential role in relapse have not been elucidated. In this study, multi-region whole-exome sequencing (WES) was performed on early-stage PTC tumors (n = 257 tumor regions) from 79 individuals, including 17 who had developed relapse, to understand the temporal and spatial framework within which subclonal mutations catalyze tumor evolution and its potential clinical relevance. Paired primary-relapse tumor tissues were also available for a subset of individuals. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849094PMC
November 2019
10.931 Impact Factor

EpCAM (MOC-31) - immunohistochemical profile and clinico-pathological correlations in different histological variants of papillary thyroid carcinoma.

Rom J Morphol Embryol 2019 ;60(2):429-436

Department of Morphofunctional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

EpCAM is a cell-adhesion molecule, located at the basolateral membrane of the normal epithelial cells. Changes in EpCAM expression are reported in several malignancies, as an early indicator for carcinogenesis. Our study aimed to evaluate the EpCAM expression in different subtypes of papillary thyroid carcinoma (PTC), focusing on its role in the risk stratification of the histological variants and its relationship with the classical clinico-pathological characteristics. Read More

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Melanoma and Thyroid Carcinoma: Our Current Understanding.

J Clin Aesthet Dermatol 2019 Sep 1;12(9):39-41. Epub 2019 Sep 1.

Dr. Lazzara is a Dermatology Resident (PGY-4) at Larkin Community Hospital Palm Springs, Lake Erie College of Osteopathic Medicine in Hialeah, Florida.

Melanoma is listed among the most common cancers in the United States, with new cases increasing steadily.1 Due to the aggressive nature of melanoma and its high risk of metastasis, early detection and treatment is essential. It is noted that the majority of unresectable and metastatic melanomas are BRAF V600-mutated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777696PMC
September 2019

Impact of overweight and obesity on U.S. papillary thyroid cancer incidence trends (1995-2015).

J Natl Cancer Inst 2019 Oct 22. Epub 2019 Oct 22.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Background: Since the early 1980s, papillary thyroid cancer (PTC) incidence rates and the prevalence of obesity, a risk factor for PTC, have increased substantially in the United States. We estimated the proportion of PTC incidence in the United States attributable to overweight/obesity during 1995-2015.

Methods: NIH-AARP Diet and Health Study cohort data (n = 457,331 participants, 50-71 years and cancer-free at baseline) were used to estimate multivariable-adjusted hazard ratios (HRs) for PTC across body mass index categories. Read More

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http://dx.doi.org/10.1093/jnci/djz202DOI Listing
October 2019
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The most reliable time point for intact parathyroid hormone measurement to predict hypoparathyroidism after total thyroidectomy with central neck dissection to treat papillary thyroid carcinoma: a prospective cohort study.

Eur Arch Otorhinolaryngol 2020 Feb 16;277(2):549-558. Epub 2019 Oct 16.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Research Institute for Medical Science, Chungnam National University, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-721, Republic of Korea.

Purpose: We assessed the optimal time for intact parathyroid hormone (iPTH) measurement for early detection of post-total thyroidectomy (TT) hypocalcemia in patients with papillary thyroid carcinoma (PTC).

Methods: In this single-center prospective cohort study, 143 patients who underwent TT with central neck dissection with or without lateral neck dissection for PTC were included. Biochemical profiles including iPTH, corrected total calcium, and ionized calcium within 24 h after surgery were analyzed. Read More

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http://dx.doi.org/10.1007/s00405-019-05693-1DOI Listing
February 2020
4 Reads