1,012 results match your criteria Thyroid Papillary Carcinoma Early


Early Calcium Supplementation After Total Thyroidectomy Can Prevent Symptomatic Hypocalcemia - Findings from a Retrospective Study.

Gulf J Oncolog 2019 Jan;1(29):60-65

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kannur, Kerala, India.

Introduction: Thyroidectomy for thyroid cancers and central neck dissection are considered as independent predictors of postoperative hypocalcemia. Post-surgical hypocalcemia is the most common and often the most difficult long-term consequence of thyroid surgeries. Management of hypocalcemia is done with calcium supplementation, but there is no consensus on the timing and the amount of calcium supplementation. Read More

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January 2019
1 Read

Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma.

Thyroid 2019 Apr 8. Epub 2019 Apr 8.

1 Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Tumor volume (TV) of papillary thyroid carcinoma (PTC) increases exponentially during active surveillance, and the growth rate differs for each patient. TV doubling time (TVDT) is considered a strong dynamic marker for the prediction of the growth rate and progression of the tumor.

Methods: This cohort study analyzed 273 PTC patients who underwent active surveillance for more than one year rather than immediate thyroid surgery. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0609
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http://dx.doi.org/10.1089/thy.2018.0609DOI Listing
April 2019
19 Reads

Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy.

Arch Endocrinol Metab 2019 Feb;63(1):79-83

Grupo Brasileiro para Estudos de Lipodistrofias Herdadas e Adquiridas (BRAZLIPO), Hospital Universitário Walter Cantídio, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Read More

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http://dx.doi.org/10.20945/2359-3997000000096DOI Listing
February 2019
3 Reads

Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy.

Int J Mol Sci 2019 Mar 5;20(5). Epub 2019 Mar 5.

College of Medicine, Touro University Nevada, 874 American Pacific Drive, Henderson, NV 89014, USA.

The diagnostic approach to thyroid cancer is one of the most challenging issues in oncology of the endocrine system because of its high incidence (3.8% of all new cancer cases in the US) and the difficulty to distinguish benign from malignant non-functional thyroid nodules and establish the cervical lymph node involvement during staging. Routine diagnosis of thyroid nodules usually relies on a fine-needle aspirate biopsy, which is invasive and often inaccurate. Read More

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http://dx.doi.org/10.3390/ijms20051114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429352PMC
March 2019
2 Reads

Clonal analysis of early-stage bilateral papillary thyroid cancer identifies field cancerization.

Endocrine 2019 Feb 26. Epub 2019 Feb 26.

Cancer Center, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Introduction: Bilaterality is a newly identified indicator for aggressive tumor behavior and poor outcome in papillary thyroid cancer. However, the clonal origin of these bilateral tumors remains unclear.

Methods: Here we analyzed 28 pairs of early-stage papillary thyroid cancers (stage I-II without extra-thyroidal extension, lymph node metastasis or distant metastasis) that underwent surgery at First Affiliated Hospital of Zhejiang University School of Medicine (Hangzhou, China). Read More

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http://dx.doi.org/10.1007/s12020-019-01877-1DOI Listing
February 2019
1 Read

Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy.

Oncol Res Treat 2019 23;42(3):136-142. Epub 2019 Feb 23.

Thyroid cancer is a rare malignancy and accounts for less than 1% of malignant neoplasms in humans; however, it is the most common cancer of the endocrine system and responsible for most deaths from endocrine cancer. Long non-coding (Lnc)RNAs are defined as non-coding transcripts that are more than 200 nucleotides in length. Their expression deregulation plays an important role in the progress of cancer. Read More

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http://dx.doi.org/10.1159/000495151DOI Listing
February 2019
1 Read

Lipase member H is a downstream molecular target of hypoxia inducible factor-1α and promotes papillary thyroid carcinoma cell migration in BCPAP and KTC-1 cell lines.

Cancer Manag Res 2019 22;11:931-941. Epub 2019 Jan 22.

Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China,

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, which is associated with a high incidence of lymph-node metastasis. Multiple biomarkers have been identified for the precise diagnosis of PTC at an early stage. However, their role in PTC remains poorly elucidated. Read More

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http://dx.doi.org/10.2147/CMAR.S183355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349079PMC
January 2019
5 Reads

Clinicopathological Significance of Overall Frequency of Allelic Loss (OFAL) in Lesions Derived from Thyroid Follicular Cell.

Mol Diagn Ther 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251 St, 92-213, Lodz, Poland.

Background: Loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumor etiopathogenesis occurring in several chromosomal critical areas, including 3p12-25.3, 7q21-31, 10q22-24, and 15q11-13, with loci of tumor suppressor genes.

Objective: We evaluated the usefulness of LOH/MSI as a diagnostic/prognostic biomarker in lesions derived from thyroid follicular cells: follicular thyroid carcinoma (FTC); follicular adenoma (FA), papillary thyroid carcinoma (PTC), and nodular goiter (NG). Read More

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http://dx.doi.org/10.1007/s40291-019-00387-0DOI Listing
February 2019
3 Reads

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Apr 27;29(4):523-529. Epub 2019 Mar 27.

1 Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach, and colorectal cancers, as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate that MSI is absent or at least very rare in the most common and most well studied histologic subtype, papillary thyroid carcinoma. This study aimed to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457885PMC
April 2019
1 Read
4.493 Impact Factor

The Expression of FOXE-1 and STIP-1 in Papillary Thyroid Carcinoma and Their Relationship with Patient Prognosis.

Iran J Pathol 2018 17;13(2):256-271. Epub 2018 Jul 17.

Dept. of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background & Objective: Most patients with papillary carcinoma of the thyroid gland (PTC) havefavorable outcome,but sinceit has severe capability to invade the nearby tissues, there isa great risk of regional and distal lymph-nodes (LNs) metastases related to poor prognostic parameters, early recurrences, and distant metastasis that lead to bad patient outcome. Discovering other prognostic biomarkers for this cancer helps to detect early recurrences, invasion, expecting patient outcome, and possible use as therapeutic-targets for it. The , with the alternative name of , is one of thetranscription factors familiesthat is huge and containsa special fork-head-domain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339506PMC
July 2018
9 Reads

Detection of BRAF V600E mutation in fine-needle aspiration fluid of papillary thyroid carcinoma by droplet digital PCR.

Clin Chim Acta 2019 Apr 22;491:91-96. Epub 2019 Jan 22.

Central Laboratory, Huashan Hospital, Fudan University, Shanghai, China; Dept. of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objectives: Papillary thyroid carcinoma (PTC) accounts for 85% of thyroid carcinoma, which is the most common endocrine tumor. For the diagnosis of PTC, ultrasound-guided fine needle aspiration (FNA) with pathological evaluation is the standard test and BRAF V600E mutation is the most common molecular marker associated with the occurrence, progression and poor clinicopathological characteristics of PTC. However, because of the small amount of the tumor cells obtained by FNA for pathological evaluation or BRAF V600E mutation detection, more sensitive and accurate methods are required. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193003
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http://dx.doi.org/10.1016/j.cca.2019.01.017DOI Listing
April 2019
15 Reads

Radiation-induced papillary thyroid cancer: is it a distinct clinical entity?

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):117-122

Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan.

Purpose Of Review: To present the current status of knowledge regarding radiation-induced papillary thyroid cancer (RIPTC), defining its epidemiologic, pathologic, and clinical characteristics, with ensuing possible therapeutic and prognostic consequences.

Recent Findings: Cumulative evidence shows that RIPTC resembles sporadic papillary thyroid cancer (PTC) of comparable age, both in terms of clinical-pathological features and prognosis. Therefore, more aggressive treatment does not seem to be required when managing RIPTC as its prognosis is comparable to that of never-irradiated patients. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000522DOI Listing
April 2019
4 Reads

An ICET-A survey on occult and emerging endocrine complications in patients with β-thalassemia major: Conclusions and recommendations.

Acta Biomed 2019 Jan 15;89(4):481-489. Epub 2019 Jan 15.

Quisisana Hospital, Ferrara.

In adult thalassemia major (TM) patients, a number of occult and emerging endocrine complications, such as: central hypothyroidism (CH), thyroid cancer, latent hypocortisolism, and growth hormone deficiency (GHD) have emerged and been reported. As the early detection of these complications is essential for appropriate treatment and follow-up, the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescent Medicine (ICET-A) promoted a survey on these complications in adult TM patients, among physicians (pediatricians, hematologists and endocrinologists) caring for TM patients in different countries. The data reported by 15 countries are presented. Read More

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http://dx.doi.org/10.23750/abm.v89i4.7774DOI Listing
January 2019
9 Reads

Risk Haplotypes Uniquely Associated with Radioiodine-Refractory Thyroid Cancer Patients of High African Ancestry.

Thyroid 2019 Apr 13;29(4):530-539. Epub 2019 Feb 13.

1 Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio.

Background: Thyroid cancer patients with radioiodine-refractory (RAI-R) disease, resulting from insufficient RAI delivery and/or RAI resistance, have increased mortality and limited treatment options. To date, studies have largely focused on tumor mutations associated with different stages of disease, which could provide prognostic value for RAI-R disease. It was hypothesized that germline variants contributing to intrinsic differences in iodine metabolism, tumor microenvironment, and/or immune surveillance are associated with RAI-R disease. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0687
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http://dx.doi.org/10.1089/thy.2018.0687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457887PMC
April 2019
10 Reads
4.493 Impact Factor

Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers.

Nutrients 2019 Jan 9;11(1). Epub 2019 Jan 9.

Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Korea.

Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side effects. Read More

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http://www.mdpi.com/2072-6643/11/1/125
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http://dx.doi.org/10.3390/nu11010125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356543PMC
January 2019
14 Reads

Role of CD10 Marker in Differentiating Malignant Thyroid Neoplasms from Benign Thyroid Lesions (Immunohistochemical & Histopathological Study).

Open Access Maced J Med Sci 2018 Dec 19;6(12):2295-2300. Epub 2018 Dec 19.

Cairo University, Cairo, Egypt.

Background: CD10 was initially recognised as a cell-surface antigen expressed by acute lymphoblastic leukaemias, and hence it's early designation as Common Acute Lymphoblastic Leukemia Antigen (CALLA). Also, it has been proven to be reactive in various non-lymphoid cells and tissue and different types of neoplasms.

Aim: To evaluate the immunohistochemical expression of CD10 in malignant thyroid neoplasms and different benign lesions and to assess whether CD10 can be used as a malignancy marker in thyroid pathology or not. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2018.456
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http://dx.doi.org/10.3889/oamjms.2018.456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311489PMC
December 2018
7 Reads

Liquid Biopsy in Thyroid Cancer: New Insight.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):235-248

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305265PMC
July 2018
4 Reads

Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study.

Lancet Oncol 2019 Feb 21;20(2):193-201. Epub 2018 Dec 21.

Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China. Electronic address:

Background: The incidence of thyroid cancer is rising steadily because of overdiagnosis and overtreatment conferred by widespread use of sensitive imaging techniques for screening. This overall incidence growth is especially driven by increased diagnosis of indolent and well-differentiated papillary subtype and early-stage thyroid cancer, whereas the incidence of advanced-stage thyroid cancer has increased marginally. Thyroid ultrasound is frequently used to diagnose thyroid cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183076
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http://dx.doi.org/10.1016/S1470-2045(18)30762-9DOI Listing
February 2019
30 Reads
24.690 Impact Factor

[Robot-assisted transaxillary thyroidectomy: our early experience].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1051-1055

Department of Otolaryngology, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, 510120, China.

To evaluate the feasibility, effectiveness and safety of robot-assisted transaxillary thyroidectomy (RATT). The clinical data of 66 patients undergoing RATT from November 2016 to May 2018 were prospectively collected and analyzed. The average age was (38. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.14.003DOI Listing
July 2018
12 Reads

Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Murine double minute clone 2 (MDM2) protein plays an important role in the regulation of p53 tumor suppressor. Genetic polymorphisms of the MDM2 gene are the candidate variants in susceptibility to various cancers. In the present study, we aimed to investigate the possible effects of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms on papillary thyroid carcinoma (PTC) susceptibility and clinical or pathological features of the disease. Read More

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http://dx.doi.org/10.1002/jcp.27960DOI Listing
December 2018

An Unusual Case Report: Occurrence of Renal Cell Carcinoma, Basal Cell Carcinoma and Chronic Lymphocytic Leukemia in a Case of Papillary Thyroid Carcinoma Treated with Radioactive Iodine.

Iran J Med Sci 2018 Nov;43(6):659-663

Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.

The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinogen including occupational and therapy related hazard, aging and genetic susceptibility are other causes of second primary cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230934PMC
November 2018
5 Reads

A cancer of undetermined significance: Incidental thyroid carcinoma.

Diagn Cytopathol 2019 May 29;47(5):412-416. Epub 2018 Nov 29.

Faculty of Medicine, Department of Endocrinology and Metabolism, Yildirim Beyazit University, Ankara, Turkey.

Introduction: The incidence of thyroid cancer is increasing which can be attributed in part to improved ultrasonography (US) methods and increased detection of incidental thyroid carcinomas (ITC). We aimed to compare ITC with nonincidental thyroid carcinomas (NITC) in this study.

Methods: Retrospective analyses of 906 individual patients who were operated for benign and malignant thyroid disease and had a final histopathological diagnosis of thyroid carcinoma were enrolled in this study. Read More

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http://dx.doi.org/10.1002/dc.24117DOI Listing
May 2019
4 Reads

Understanding Malignancies of the Thyroid Gland: Institutional Experience.

Indian J Otolaryngol Head Neck Surg 2018 Dec 5;70(4):482-489. Epub 2018 Sep 5.

1Department of Otolaryngology and Head Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

To study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10 years are available were included in the study. Read More

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http://dx.doi.org/10.1007/s12070-018-1492-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224818PMC
December 2018
14 Reads

Serum levels of intact parathyroid hormone on the first day after total thyroidectomy as predictor of permanent hypoparathyroidism.

Endocrinol Diabetes Nutr 2019 Mar 2;66(3):195-201. Epub 2018 Nov 2.

Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.

Background: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy, causing significant morbidity and requiring long-term replacement therapy. Our study objective was to assess whether intact parathyroid hormone (iPTH) levels on the first day after total thyroidectomy are a good predictor of permanent hypoparathyroidism.

Patients And Methods: A retrospective observational study of all patients undergoing total thyroidectomy between January 2009 and December 2014. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.08.006DOI Listing
March 2019
4 Reads

Individualized Follow-Up Strategy for Patients with an Indeterminate Response to Initial Therapy for Papillary Thyroid Carcinoma.

Thyroid 2019 Feb 14;29(2):209-215. Epub 2018 Dec 14.

1 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: The concept of a dynamic risk-stratification scheme has been suggested for individualized management of patients with papillary thyroid carcinoma (PTC). However, there is no specified follow-up strategy for patients with an indeterminate response.

Methods: This study evaluated 403 PTC patients who had an indeterminate response during the first 12-24 months after initial therapy. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0391
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http://dx.doi.org/10.1089/thy.2018.0391DOI Listing
February 2019
3 Reads

Lung Recurrence of Papillary Thyroid Cancer Diagnosed With Antithyroglobulin Antibodies After 10 Years From Initial Treatment.

Front Endocrinol (Lausanne) 2018 9;9:590. Epub 2018 Oct 9.

Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Papillary thyroid cancer (PTC) is the most common endocrine malignancy. More than 98% of patients achieve an excellent response with no evidence of clinical, biochemical, or structural disease after initial treatment. In these patients structural recurrence is rare, more frequently diagnosed in the first 5 years from initial treatment and almost invariably localized in neck lymph nodes. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00590
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http://dx.doi.org/10.3389/fendo.2018.00590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190843PMC
October 2018
20 Reads

Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells.

Thyroid Res 2018 11;11:13. Epub 2018 Oct 11.

2Department of General Surgery, the affiliated Hospital of Qingdao University, Qingdao, Shandong China.

Background And Aims: The activating mutation BRAF is a frequent genetic event in papillary thyroid carcinomas (PTC). Mutation BRAF is associated with the loss of a sodium/iodine symporter (NIS), and subsequent radioiodide-refractory (RAI) metastatic disease. Use of BRAF V600E inhibitors could partly restore NIS expression and Iodide uptake by inhibition of mitogen-activated protein kinase (MAPK) pathway. Read More

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http://dx.doi.org/10.1186/s13044-018-0057-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180498PMC
October 2018
6 Reads

Characterizing the three-dimensional organization of telomeres in papillary thyroid carcinoma cells.

J Cell Physiol 2019 Apr 17;234(4):5175-5185. Epub 2018 Oct 17.

Department of Cell Biology, Research Institute of Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada.

The relationship between the three-dimensional (3D) nuclear telomere architecture and specific genetic alterations in papillary thyroid carcinoma (PTC), in particular in cancer stem-like cells (CSLCs), has not yet been investigated. We isolated thyrospheres containing CSLCs from B-CPAP, K1, and TPC-1 PTC-derived cell lines, representative of tumors with different genetic backgrounds within the newly identified BRAF -like PTC subgroup, and used immortalized normal human thyrocytes (Nthy-ori 3.1) as control. Read More

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http://doi.wiley.com/10.1002/jcp.27321
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http://dx.doi.org/10.1002/jcp.27321DOI Listing
April 2019
3 Reads

mRNA and miRNA expression profiling of follicular variant of papillary thyroid carcinoma with and without distant metastases.

Mol Cell Endocrinol 2019 Jan 24;479:93-102. Epub 2018 Sep 24.

Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, via Savi 10, 56126, Pisa, Italy. Electronic address:

Follicular Variant of Papillary Thyroid Carcinoma (FVPTC) is usually associated with a good outcome. Nevertheless, in rare cases, it develops distant metastases (1-9%). Our goal was to investigate whether mRNA and miRNA expression profiles may help distinguish between metastatic versus non-metastatic FVPTCs. Read More

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http://dx.doi.org/10.1016/j.mce.2018.09.005DOI Listing
January 2019
3 Reads

Early Onset Multiple Primary Tumors in Atypical Presentation of Cowden Syndrome Identified by Whole-Exome-Sequencing.

Front Genet 2018 31;9:353. Epub 2018 Aug 31.

INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Université Clermont Auvergne, Clermont-Ferrand, France.

A family with an aggregation of rare early onset multiple primary tumors has been managed in our oncogenetics department: the proband developed four early onset carcinomas between ages 31 and 33 years, including acral melanoma, bilateral clear cell renal carcinoma (RC), and follicular variant of papillary thyroid carcinoma. The proband's parent developed orbital lymphoma and small intestine mucosa-associated lymphoid tissue (MALT) lymphoma between 40 and 50 years old. Whole-exome-sequencing (WES) of the nuclear family (proband, parents, and sibling) identified in the proband a deleterious heterozygous mutation c. Read More

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http://dx.doi.org/10.3389/fgene.2018.00353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127642PMC
August 2018
4 Reads

Patients with Oncocytic Variant Papillary Thyroid Carcinoma Have a Similar Prognosis to Matched Classical Papillary Thyroid Carcinoma Controls.

Thyroid 2018 11;28(11):1462-1467

1 Department of Surgery, Medical College of Wisconsin , Milwaukee, Wisconsin.

Background: Previous studies have suggested that oncocytic variant papillary thyroid carcinoma (PTC) may be more aggressive, with higher rates of recurrent disease. The aim of this study was to evaluate characteristics and outcomes of patients with oncocytic variant PTC compared to classical PTC.

Methods: Patients with oncocytic variant PTC were retrospectively identified from 519 patients who underwent thyroidectomy for PTC between January 2009 and August 2015. Read More

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http://dx.doi.org/10.1089/thy.2017.0603DOI Listing
November 2018
4 Reads

Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics.

Eur Arch Otorhinolaryngol 2018 Nov 4;275(11):2823-2828. Epub 2018 Sep 4.

Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China.

Background: The incidence of thyroid cancer is fast increasing in both adults and children. The pediatric thyroid cancer had often already progressed to a more advanced stage of the disease at diagnosis. Early detection of pediatric thyroid cancer has been a problem for many years. Read More

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http://link.springer.com/10.1007/s00405-018-5118-x
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http://dx.doi.org/10.1007/s00405-018-5118-xDOI Listing
November 2018
16 Reads

Clonal evolution analysis of paired anaplastic and well-differentiated thyroid carcinomas reveals shared common ancestor.

Genes Chromosomes Cancer 2018 12 24;57(12):645-652. Epub 2018 Sep 24.

Yale Endocrine Neoplasia Laboratory, Yale School of Medicine, New Haven, Connecticut.

Foci of papillary or follicular thyroid carcinoma are frequently noted in thyroidectomy specimens of anaplastic thyroid carcinoma (ATC). However, whether ATCs evolve from these co-existing well-differentiated thyroid carcinomas (WDTCs) has not been well-understood. To investigate the progression of ATC in patients with co-existing WDTCs, five ATC tumors with co-existing WDTCs and matching normal tissues were whole-exome sequenced. Read More

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http://dx.doi.org/10.1002/gcc.22678DOI Listing
December 2018
30 Reads

Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma.

Int J Cancer 2019 Mar 24;144(6):1321-1330. Epub 2018 Sep 24.

Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, China.

Although the genotype-phenotype for familial medullary thyroid carcinoma (FMTC) is well studied, only few low susceptibility risk loci were identified for familial non-medullary thyroid carcinoma (FNMTC). The aim of this study is to screen and identify high-penetrate genes for FNMTC. A total of 34 families with more than two first-degree relatives diagnosed as papillary thyroid cancer without other familial syndrome were recruited. Read More

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http://dx.doi.org/10.1002/ijc.31825DOI Listing
March 2019
18 Reads
5.080 Impact Factor

Bleomycin inhibits proliferation and induces apoptosis in TPC-1 cells through reversing M2-macrophages polarization.

Oncol Lett 2018 Sep 6;16(3):3858-3866. Epub 2018 Jul 6.

College of Integrated Traditional Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, P.R. China.

Papillary thyroid carcinoma (PTC) is one of the most common types of thyroid malignancy. Previous studies have demonstrated that the density of tumor-associated macrophages (TAMs) within the tumor microenvironment affects the progression of PTC due to the imbalance in M1/M2 macrophage subtypes. M2 macrophages induce anti-inflammatory effects and promote tumor progression, whereas M1 macrophages destroy tumor cells. Read More

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http://dx.doi.org/10.3892/ol.2018.9103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096247PMC
September 2018
3 Reads

The prognostic value of serum thyroid-stimulating hormone level post-lobectomy in low- and intermediate-risk papillary thyroid carcinoma.

J Surg Oncol 2018 Sep 16;118(3):390-396. Epub 2018 Aug 16.

Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea.

Background: This study was undertaken to determine the optimal thyroid-stimulating hormone (TSH) value associated with structural recurrence in patients with low-risk or intermediate-risk papillary thyroid carcinoma (PTC) who underwent thyroid lobectomy.

Methods: Patients with PTC (n = 1047) who received thyroid lobectomy and central compartment node dissection were included in the study.

Results: Structural recurrence occurred in 42 of the patients (4. Read More

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http://dx.doi.org/10.1002/jso.25164DOI Listing
September 2018
2 Reads

Intermediate-Risk Papillary Thyroid Cancer: Risk Factors for Early Recurrence in Patients with Excellent Response to Initial Therapy.

Thyroid 2018 10;28(10):1311-1317

3 Departamento de Cirugía, Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional de Colombia , Bogota, Colombia .

Background: Patients with excellent response to initial therapy have a low rate of tumor recurrence. The objectives of this study were to evaluate the rate of early tumor recurrence in patients with intermediate-risk papillary thyroid cancer who had an excellent response to initial treatment and to identify risk factors.

Methods: This retrospective cohort study included 217 patients with American Thyroid Association intermediate-risk papillary thyroid cancer who had a documented excellent response to initial treatment (total thyroidectomy and adjuvant therapy with 100-150 mCi [3. Read More

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http://dx.doi.org/10.1089/thy.2017.0578DOI Listing
October 2018

Rapid Growth and Early Metastasis of Papillary Thyroid Carcinoma in an Adolescent Girl with Graves' Disease.

Horm Res Paediatr 2018 Aug 9:1-6. Epub 2018 Aug 9.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Background: The risk factors for rapid growth and early metastasis of papillary thyroid carcinoma (PTC) and the role of coexisting Graves' disease in the clinical course of PTC remain uncertain in children.

Case Description: We report on a Japanese girl, whose PTC rapidly grew and metastasized within 4 years. Graves' disease was diagnosed by the presence of serum TSH receptor antibodies at 8 years of age when thyroid ultrasonography detected no nodules. Read More

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http://dx.doi.org/10.1159/000491102DOI Listing
August 2018
33 Reads

A Comparison of Clinicopathological Characteristics and Short-Term Outcome of Papillary Thyroid Carcinoma with Tall Cell Histology and Classic Papillary Thyroid Carcinoma: A Single-Institution Experience.

Indian J Endocrinol Metab 2018 May-Jun;22(3):405-409

Department of Endocrinology, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India.

Context: Papillary thyroid carcinoma with tall cell histology (PTC-TCH) is an aggressive subtype in terms of clinicopathological features and outcome. Even 10% of tall cells can show aggressive features.

Aims: The aim of this study is to investigate the behavior of PTC-TCH, to compare with classic PTC (cPTC), and evaluate the short-term outcome. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_65_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063188PMC
August 2018
27 Reads

Thyroid Autoimmunity and Thyroid Cancer - The Pathogenic Connection: A 2018 Update.

Authors:
Yuji Nagayama

Horm Metab Res 2018 Dec 6;50(12):922-931. Epub 2018 Aug 6.

Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

The association between thyroid cancer and thyroid autoimmunity has long been suggested, but remains to be elucidated for several decades. Here the data on this issue are updated by summarizing relevant papers published between 2012 and early 2018. Although numerous papers demonstrated the significant increase in the prevalence of thyroid autoimmunity (positive intrathyroidal lymphocyte infiltration and/or anti-thyroglobulin/thyroid peroxidase antibodies) in patients with thyroid cancers as compared to those with benign nodules, and also the significant increase in the prevalence of papillary thyroid cancer (PTC) in patients with thyroid autoimmunity as compared to those without, there are some crucial biases that should be taken into account for their interpretation. Read More

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http://dx.doi.org/10.1055/a-0648-4593DOI Listing
December 2018
2 Reads

Importance of combined approach of investigations for detection of asymptomatic Hashimoto Thyroiditis in early stage.

J Lab Physicians 2018 Jul-Sep;10(3):294-298

Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.

Introduction: Hashimoto's thyroiditis (HT) is the most common cause of goitrous hypothyroidism in iodine sufficient areas. The diagnosis of HT is important because it progresses to hypothyroidism, and also, it is associated with thyroid lymphoma and papillary thyroid carcinoma. Apart from thyroid antibodies, assessment of thyroid function test (TFT) levels, ultrasonography (USG), and cytological analysis can help in early diagnosis and management of HT. Read More

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http://dx.doi.org/10.4103/JLP.JLP_72_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052823PMC
August 2018
5 Reads

Differentiation between metastatic and tumour-free cervical lymph nodes in patients with papillary thyroid carcinoma by grey-scale sonographic texture analysis.

Pol J Radiol 2018 4;83:e37-e46. Epub 2018 Feb 4.

Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Purpose: Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, and cervical lymph nodes (LNs) are the most common extrathyroid metastatic involvement. Early detection and reliable diagnosis of LNs can lead to improved cure rates and management costs. This study explored the potential of texture analysis for texture-based classification of tumour-free and metastatic cervical LNs of PTC in ultrasound imaging. Read More

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http://dx.doi.org/10.5114/pjr.2018.75017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047085PMC
February 2018
5 Reads

Applicability of sentinel lymph node biopsy in papillary thyroid cancer.

Q J Nucl Med Mol Imaging 2018 Jul 9. Epub 2018 Jul 9.

Department of Surgery, Institut de Malalties Digestives I Metabòliques, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Background: The optimal surgical management of papillary thyroid cancer (PTC) for T1-T2 tumors without pre or intrasurgical evidence of lymph node metastasis (cN0) remains controversial, since approximately 40% of patients have lymph node involvement (pN1) which becomes evident when a prophylactic lymphadenectomy (PL) is performed. The aim of this study was to investigate the feasibility of sentinel lymph node (SLN) identification with SPECT/CT lymphoscintigraphy imaging along with intraoperatory image techniques in early stages of PTC undergoing PL of central neck compartment (CNC).

Methods: A single-center, prospective consecutive study was designed for SLN mapping in patients with high suspicion of PTC (Bethesda V or VI) in early stage (cT1-2, cN0). Read More

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http://dx.doi.org/10.23736/S1824-4785.18.03097-2DOI Listing
July 2018
25 Reads

Reliable information for cancer control in Cali, Colombia.

Colomb Med (Cali) 2018 Mar 30;49(1):23-34. Epub 2018 Mar 30.

Secretaria de Salud Pública Municipal de Cali, Cali, Colombia.

Background: The Cali Population Cancer Registry (RPCC) has been in continuous operation since 1962 with the objective of producing valid statistics on the incidence of cancer, its patterns, trends and survival rates.

Methods: During the period 2008-2012, 23,046 new cases were registered and during 2011-2015 there were 12,761 cancer deaths. The trend of the rates was described with the APC average annual change rate and with the Joinpoint analysis. Read More

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http://dx.doi.org/10.25100/cm.v49i1.3689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018818PMC
March 2018
14 Reads

Identification of Biomarkers Based on Differentially Expressed Genes in Papillary Thyroid Carcinoma.

Sci Rep 2018 Jul 2;8(1):9912. Epub 2018 Jul 2.

Department of Endoerinology and Metabolism, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.

The incidence of papillary thyroid carcinoma (PTC) is increasing rapidly throughout the world. Hence, there is an urgent need for identifying more specific and sensitive biomarkers to explorate the pathogenesis of PTC. In this study, three pairs of stage I PTC tissues and matched normal adjacent tissues were sequenced by RNA-Seq, and 719 differentially expressed genes (DEGs) were screened. Read More

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http://dx.doi.org/10.1038/s41598-018-28299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028435PMC
July 2018
8 Reads

Magnetic resonance imaging in the prediction of aggressive histological features in papillary thyroid carcinoma.

Medicine (Baltimore) 2018 Jun;97(26):e11279

Department of Radiology.

To identify magnetic resonance imaging (MRI) features in the prediction of tumor aggressiveness in patients with papillary thyroid carcinoma (PTC).In this prospective study, 105 patients with 122 PTCs underwent MRI with T1-weighted, T2-weighted, diffusion-weighted imaging and contrast-enhanced sequences prior to thyroidectomy. Based on exclusion criteria, 62 patients with 62 PTCs were finally suitable for further analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000011279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039645PMC
June 2018
6 Reads

Autoimmune disease, familial clustering and thyroid carcinoma coexistent with autoimmune thyroiditis in children and adolescence: A cross-sectional study from the Czech Republic.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Jun 7. Epub 2018 Jun 7.

Department of Paediatrics, Charles University in Prague, Faculty of Medicine in Pilsen, Czech Republic.

Background: The prevalence of autoimmune thyroiditis (AIT), as the most common autoimmune disease (AD) and papillary thyroid cancer (PTC) is steadily rising in children. The aim of this study was to determine the coexistence of other AD and thyroid carcinoma (TC) in AIT.

Methods: The cross-sectional study conducted at a tertiary center comprised AIT children (< 19 years). Read More

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http://dx.doi.org/10.5507/bp.2018.030DOI Listing
June 2018
9 Reads

An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter.

J Family Med Prim Care 2018 Jan-Feb;7(1):224-229

Inflammatory Lung Disease Research Center, School of Medicine, Razi Hospital, Guilan University of Medical Science, Rasht, Iran.

Introduction: Retrosternal goiter refers to any thyroid enlargement in which over 50% of the thyroid permanently located under the thoracic inlet or the lower pole of thyroid is not palpable with the neck in hyperextended position. Due to the increasing number of surgical procedures of retrosternal goiter, the present study was carried out to examine the symptoms, diagnosis, treatment, and treatment complications in retrosternal goiter patients.

Materials And Methods: Data related to demographic data (age and gender), clinical symptoms (dyspnea, dysphagia, dysphonia, lumps in neck, and hoarseness), methods of diagnosis (computed tomography [CT], chest X-ray [CXR], ultrasonography, and magnetic resonance imaging), and postoperative complications (bleeding, early and late dysphonia, early and late dyspnea, transient and permanent hypocalcemia, transient, and permanent recurrent laryngeal nerve paralysis) were collected. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_286_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958574PMC
June 2018
21 Reads

The Outcome of Papillary Thyroid Cancer Associated with Graves' Disease: A Case Control Study.

J Thyroid Res 2018 8;2018:8253094. Epub 2018 May 8.

Department of General Surgery, Endocrine Surgery Division, Amrita Institute of Medical Sciences, Kochi, Kerala 682041, India.

Introduction: Thyroidectomy is now a less popular therapeutic option for Graves' disease. The frequency of thyroid nodule and the cancer risk of these nodules accompanying Graves' disease are controversial. The outcome of thyroid cancers coexisting with Graves' disease is debated. Read More

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http://dx.doi.org/10.1155/2018/8253094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964588PMC
May 2018
4 Reads

Central Lymph Node Status has Significant Prognostic Value in the Clinically Node-Negative Tall-Cell Variant of Papillary Thyroid Cancer Regardless of T-Staging and Radioactive Iodine Administration: First Evidence From a Population-Based Study.

Ann Surg Oncol 2018 Aug 29;25(8):2316-2322. Epub 2018 May 29.

Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: The prognostic value of central lymph node (CLN) status in papillary thyroid cancer (PTC) remains controversial. This study aimed to provide the first evidence on this issue for the aggressive tall-cell variant (TCV) subtype.

Methods: The study identified TCV patients from the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1245/s10434-018-6542-2DOI Listing
August 2018
2 Reads