1,163 results match your criteria Thyroid Papillary Carcinoma Early


How to identify indolent thyroid tumors unlikely to recur and cause cancer death immediately after surgery-Risk stratification of papillary thyroid carcinoma in young patients.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Current histopathological diagnosis methods cannot distinguish the two types of thyroid carcinoma: clinically significant carcinomas with a potential risk of recurrence, metastasis, and cancer death, and clinically insignificant carcinomas with a slow growth rate. Both thyroid tumors are diagnosed as "carcinoma" in current pathology practice. The clinician usually recommends surgery to the patient and the patient often accepts it because of cancer terminology. Read More

View Article and Full-Text PDF

EGR1/2 Inhibits Papillary Thyroid Carcinoma Cell Growth by Suppressing the Expression of PTEN and BAX.

Biochem Genet 2021 May 10. Epub 2021 May 10.

Department of General Surgery, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, 050000, Hebei, China.

Early growth response (EGR) proteins have been reported to be involved in cell growth and apoptosis in a variety of cancer types and could inhibit tumor development. However, the role of EGR1/2 in papillary thyroid carcinoma (PTC) has not been elucidated. The expression pattern of EGR1/2 in adjacent tissues and cancer tissues and the clinical prognosis of EGR1/2 were analyzed by using the samples from TCGA database. Read More

View Article and Full-Text PDF

Dysregulation of microRNAs as the risk factor of lymph node metastasis in papillary thyroid carcinoma: systematic review.

Endokrynol Pol 2021 ;72(2):145-152

Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Papillary thyroid carcinoma (PTC) has an excellent prognosis with a relatively low mortality rate, but a small portion of PTC patients suffer from an aggressive form of the disease. In such cases early detection of lymph node metastasis (LNM) is as paramount as it is problematic. The routine use of central neck lymph node dissection is not recommended. Read More

View Article and Full-Text PDF
January 2021

Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies.

Exp Ther Med 2021 Jun 14;21(6):607. Epub 2021 Apr 14.

Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Thyroid cancer accounts for 1% of all malignancies, and is becoming increasingly common worldwide. The literature reports a prevalence of ~50% of thyroid nodules detected during autopsies in subjects with unknown thyroid pathology. An extended retrospective study of 526 autopsy cases was performed to identify the prevalence of thyroid carcinoma, among various types of thyroid nodules identified incidentally. Read More

View Article and Full-Text PDF

Limited Clinical and Diagnostic Utility of Circulating Tumor DNA Detection in Patients with Early-Stage Well-Differentiated Thyroid Cancer: Comparison with Benign Thyroid Nodules and Healthy Individuals.

Healthcare (Basel) 2021 Apr 1;9(4). Epub 2021 Apr 1.

Hallym University Medical Center, Hallym Institute of Translational Genomics and Bioinformatics, Anyang 14068, Gyeonggi-do, Korea.

Limited data are available on the diagnostic utility of circulating tumor DNA (ctDNA) in early-stage thyroid cancers for , , , and promoter mutations, which are known detectable markers for thyroid cancers. Here, we analyzed the above driver mutations in ctDNA and matched neoplastic tissues from patients with early-stage thyroid cancers in order to investigate diagnostic utility of circulating markers in distinguishing from other mimicking thyroid lesions and healthy individuals. In total, 73 matched neoplastic tissue and plasma samples [thyroid cancers (n = 62), benign thyroid disorders (n = 8), and parathyroid lesions (n = 3)] and 54 plasma samples from healthy individuals (as controls) were analyzed for , , , and promoter mutations using peptide nucleic acid clamp real-time PCR. Read More

View Article and Full-Text PDF

Morbidity and mortality associated with thyroid surgery - retrospective analysis 19912010.

Rozhl Chir 2021 ;100(3):118-125

Introduction: The incidence of thyroid disorders has been rising worldwide. Unlike the incidence, mortality associated with malignant thyroid cancer shows only a modest increase. Between 1979 and 2009, mortality in Czech women increased from 1. Read More

View Article and Full-Text PDF

Value of Combining Clinical Factors, Conventional Ultrasound, and Contrast-Enhanced Ultrasound Features in Preoperative Prediction of Central Lymph Node Metastases of Different Sized Papillary Thyroid Carcinomas.

Cancer Manag Res 2021 19;13:3403-3415. Epub 2021 Apr 19.

Department of Pathology, Lanzhou University Second Hospital, Lanzhou, Gansu, People's Republic of China.

Purpose: Early and accurate preoperative diagnosis of central lymph node metastasis (CLNM) is crucial to improve surgical management of patients with clinical lymph node-negative papillary thyroid carcinoma (PTC). Towards improving diagnosis of CLNM, we assessed the value of combining preoperative clinical characteristics, conventional ultrasound, and contrast-enhanced ultrasound (CEUS) in preoperative prediction of CLNM of different sized PTCs.

Patients And Methods: Patients were divided according to tumor size: a PTC group (>10 mm) and a papillary thyroid microcarcinoma (PTMC) group (≤10 mm). Read More

View Article and Full-Text PDF

Second Malignancies after Radiation Therapy: Update on Pathogenesis and Cross-sectional Imaging Findings.

Radiographics 2021 May-Jun;41(3):876-894. Epub 2021 Apr 23.

From the Department of Radiology, University of Texas Health at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 (L.K., A.M.P., V.S.K.); Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (S.R.P., S.Y., L.P.M.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (K.S., C.O.M.); and Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio (S.H.T.).

A wide spectrum of second cancers occur as late complications of radiation therapy (RT) used to treat various malignancies. In addition to the type and dose of radiation, lifestyle, environmental, and genetic factors are important to the development of second malignancies in cancer survivors. Typically, RT-induced malignancies (RTIMs) are biologically aggressive cancers with a variable period of 5-10 years for hematologic malignancies and 10-60 years for solid tumors between RT and the development of the second cancer. Read More

View Article and Full-Text PDF

Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.

Science 2021 May 22;372(6543). Epub 2021 Apr 22.

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (I)-exposed children. We analyzed genomic, transcriptomic, and epigenomic characteristics of 440 PTCs from Ukraine (from 359 individuals with estimated childhood I exposure and 81 unexposed children born after 1986). PTCs displayed radiation dose-dependent enrichment of fusion drivers, nearly all in the mitogen-activated protein kinase pathway, and increases in small deletions and simple/balanced structural variants that were clonal and bore hallmarks of nonhomologous end-joining repair. Read More

View Article and Full-Text PDF

Total Thyroidectomy vs Thyroid Lobectomy for Localized Papillary Thyroid Cancer in Children: A Propensity-Matched Survival Analysis.

J Am Coll Surg 2021 Apr 3. Epub 2021 Apr 3.

Section of Endocrine Surgery, Department of Surgery, University of Chicago Medicine. Chicago IL USA.

Introduction: Current guidelines recommend total thyroidectomy (TT) and radio-ablation for most papillary thyroid cancer (PTC) in children. These guidelines have been criticized as aggressive, especially for early-stage PTC, as it likely does not influence patient survival and results in life-long thyroid hormone replacement. We sought to study whether the extent of thyroidectomy (TT vs. Read More

View Article and Full-Text PDF

Differential expression of Vitamin D binding protein in thyroid cancer health disparities.

Oncotarget 2021 Mar 30;12(7):596-607. Epub 2021 Mar 30.

Division of Biochemistry, Loma Linda, CA 92350, USA.

Thyroid cancer incidence, recurrence, and death rates are higher among Filipino Americans than European Americans. We propose that vitamin D binding protein (DBP) with multifunctionality with ethnic variability plays a key role within different ethnicities. In this study, we determined the correlation between differential DBP expression in tumor tissues and cancer staging in Filipino Americans versus European Americans. Read More

View Article and Full-Text PDF

Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma.

Endocr Relat Cancer 2021 Apr 29;28(5):337-351. Epub 2021 Apr 29.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Pediatric papillary thyroid carcinomas (pPTCs) are often indolent tumors with excellent long-term outcome, although subsets of cases are clinically troublesome and recur. Although it is generally thought to exhibit similar molecular aberrancies as their counterpart tumors in adults, the pan-genomic landscape of clinically aggressive pPTCs has not been previously described. In this study, five pairs of primary and synchronously metastatic pPTC from patients with high-risk phenotypes were characterized using parallel whole-genome and -transcriptome sequencing. Read More

View Article and Full-Text PDF

Advancements in the treatment of differentiated thyroid cancer.

Ther Adv Endocrinol Metab 2021 17;12:20420188211000251. Epub 2021 Mar 17.

Department of Endocrine Surgery, Columbia University, 161 Fort Washington Ave, 8th Floor, New York, NY 10032, USA.

Derived from follicular epithelial cells, differentiated thyroid cancer (DTC) accounts for the majority of thyroid malignancies. The threefold increase in DTC incidence over the last three decades has been largely attributed to advancements in detection of papillary thyroid microcarcinomas. Efforts to address the issue of overtreatment have notably included the reclassification of encapsulated follicular variant papillary thyroid cancers (EFVPTC) to non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Read More

View Article and Full-Text PDF

Highly Sensitive Detection of Low-Abundance BRAF V600E Mutation in Fine-Needle Aspiration Samples by Zip Recombinase Polymerase Amplification.

Anal Chem 2021 04 25;93(13):5621-5628. Epub 2021 Mar 25.

The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China.

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer with high incidence in endocrine tumors, which emphasizes the significance of accurate diagnostics. Still, the commonly used cytological method (fine-needle aspiration (FNA) cytology) and molecular diagnostic methods (such as PCR and sequencing) are limited in terms of diagnostic time, sensitivity, and user-friendliness. In this study, we introduce a novel Zip recombinase polymerase amplification (Z-RPA) strategy to efficiently detect rare mutant alleles in PTC fine-needle aspiration samples, which is sensitive, fast, and simple to manipulate. Read More

View Article and Full-Text PDF

The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients.

Front Oncol 2021 5;11:645156. Epub 2021 Mar 5.

Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.

The objective of this study is to summarize the clinical and pathologic characteristics of malignant struma ovarii to facilitate the early diagnosis and treatment of this disease. All 144 patients were females from 27 countries. The mean age of the patients at diagnosis was 42. Read More

View Article and Full-Text PDF

Controversy: For or against thyroid lobectomy in>1cm differentiated thyroid cancer?

Ann Endocrinol (Paris) 2021 Apr 20;82(2):78-82. Epub 2021 Mar 20.

Department of endocrine surgery, Hôpital Lyon Sud, 165, rue du grand Revoyet, 69495 Pierre-Bénite, France; Inserm U1290, Research on Healthcare Performance Lab (RESHAPE), Université Claude-Bernard Lyon 1, domaine Rockefeller, 8, avenue Rockefeller, 69003 Lyon, France. Electronic address:

In this controversy article, the respective advantages of lobectomy vs. total thyroidectomy in differentiated thyroid cancers are argued. The authors conclude that lobectomy has the same oncological prognosis as thyroidectomy in terms of specific survival or recurrence, in case of low risk of recurrence (T1-2N0). Read More

View Article and Full-Text PDF

Investigating the demographic characteristics and pathological manifestations of thyroid Cancer during the last two decades (1997-2017) in patients referred to Baqiyatallah hospital, Tehran, Iran.

J Diabetes Metab Disord 2020 Dec 23;19(2):1165-1172. Epub 2020 Aug 23.

Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background & Objective: Thyroid cancer is among the most common endocrine cancers, and its incidence in our country is in progress over the past decades. This aggravates the necessity to evaluate the changes in thyroid cancer.

Materials & Methods: Through accessing the information of the records of all patients with a diagnosis of thyroid cancer between 1996 and 2017, the present study was conducted at Baqiyatallah Hospital (Tehran, Iran) according to scientific criteria. Read More

View Article and Full-Text PDF
December 2020

Metastatic Papillary Thyroid Carcinoma in a Paediatric Patient.

Case Rep Endocrinol 2021 5;2021:6655491. Epub 2021 Jan 5.

Department of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Services, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.

Papillary thyroid carcinoma is the most common endocrine cancer in the paediatric population. Although the disease is diagnosed at a later stage, the prognosis is favourable. When these patients present with lymph nodal and/or pulmonary metastases, they may be initially confused for infectious diseases such as tuberculosis. Read More

View Article and Full-Text PDF
January 2021

High Risk Thyroid Nodule Discrimination and Management by Modified TI-RADS.

Cancer Manag Res 2021 11;13:225-234. Epub 2021 Jan 11.

Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.

Objective: Thyroid cancer is the most common primary malignant disorder of the thyroid. We aimed to illustrate the modified TI-RADS report system for differentiating malignant thyroid nodules from benign ones, and especially its role in the management of high risk nodules.

Methods: In this retrospective study, 5,162 healthy individuals who underwent thyroid ultrasound according to modified TI-RADS from January 2014 to December 2014 were enrolled and followed up during the whole 5 years, and the medical data were investigated and reviewed. Read More

View Article and Full-Text PDF
January 2021

[Response to lenvatinib in a pediatric patient with respiratory failure associated with papillary thyroid carcinoma].

Arch Argent Pediatr 2021 02;119(1):e70-e74

Servicio de Endocrinología, Hospital J. P. Garrahan.

Papillary thyroid cancer is the most common thyroid tumor in childhood. In advanced stages, it can present with respiratory failure. The treatment of choice is total thyroidectomy and radioactive iodine. Read More

View Article and Full-Text PDF
February 2021

miR-1301-3p suppresses tumor growth by downregulating PCNA in thyroid papillary cancer.

Am J Otolaryngol 2021 Mar-Apr;42(2):102920. Epub 2021 Jan 9.

Department of Thyroid Surgery, Affiliated Hospital of Southwest Medical University, LuZhou, China. Electronic address:

Objective: Thyroid carcinoma is the most common endocrine tumor, and thyroid papillary carcinoma is the most common form. Although thyroid papillary carcinoma presents a good prognosis, some patients still exhibit recurrence or distant metastasis. miR-1301-3p has been found involved in the occurrence and development of some special tumors. Read More

View Article and Full-Text PDF
January 2021

Case report and literature review: Horner syndrome subsequent to endoscopic thyroid surgery.

BMC Surg 2021 Jan 13;21(1):36. Epub 2021 Jan 13.

Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, No.74, Linjiang Rd, Yuzhong Dist, Chongqing, 404100, People's Republic of China.

Background: Horner syndrome (HS), mainly characterized by symptoms including ptosis, miosis, and anhidrosis on the affected face, is a condition that is well documented but rarely reported as a postoperative complication of thyroidectomy, particularly in endoscopic thyroid surgery (ETS). We hereby report a case of HS due to ETS with a brief literature review on this topic.

Case Presentation: A 31-year-old female was admitted to our hospital with an unexpected physical examination finding of two thyroid nodules that were hypoechoic, had an irregular shape, and exhibited calcification. Read More

View Article and Full-Text PDF
January 2021

Selective Use of Radioactive Iodine Therapy for Papillary Thyroid Cancers With Low or Lower-Intermediate Recurrence Risk.

J Clin Endocrinol Metab 2021 Mar;106(4):e1717-e1727

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Context: Current guidelines recommend a selective use of radioiodine treatment (RAI) for papillary thyroid cancer (PTC).

Objective: This work aimed to determine how policy changes affect the use of RAI and the short-term outcomes of patients.

Methods: A retrospective analysis of longitudinal data was conducted in an academic referral center of patients with nonaggressive PTC variants; no extrathyroidal invasion or limited to soft tissues, no distant metastases, and 5 or fewer central-compartment cervical lymph node metastases. Read More

View Article and Full-Text PDF

Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study.

Lancet Diabetes Endocrinol 2021 02 18;9(2):94-105. Epub 2020 Dec 18.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway.

Background: Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). The incidence of thyroid cancer is higher in women than men diagnosed from early adolescence. However, few in-utero and early life risk exposures associated with increased risk of thyroid cancer have been identified. Read More

View Article and Full-Text PDF
February 2021

Progression of incidence and estimate of net survival from papillary thyroid cancers diagnosed between 2008 and 2016 in France.

Ann Endocrinol (Paris) 2020 Dec 5;81(6):530-538. Epub 2020 Dec 5.

FRANCIM, 1, avenue Irène-Joliot-Curie, 31059 Toulouse, France.

Background: After several decades of increasing incidence of papillary thyroid cancer (PTC), a change in this trend has been recently observed, particularly in the United States. This is attributed to the impact of new guidelines for the management of thyroid disease. The objective of this study was to describe the recent situation in France in terms of incidence and survival, taking account of tumor size. Read More

View Article and Full-Text PDF
December 2020

Annual Hazard Rate of Recurrence in Middle Eastern Papillary Thyroid Cancer over a Long-Term Follow-Up.

Cancers (Basel) 2020 Dec 3;12(12). Epub 2020 Dec 3.

Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Predicting the pattern of recurrence in papillary thyroid cancer (PTC) is necessary to establish optimal surveillance and treatment strategies. We analyzed changes in hazard rate (HR) for tumor recurrence over time in 1201 unselected Middle Eastern PTC patients. The changes in risk were further analyzed according to clinical variables predictive of early (≤5 years) and late (>5 years) recurrence using Cox regression analysis to identify patient populations that remain at risk. Read More

View Article and Full-Text PDF
December 2020

A versatile magnetic bead-based flow cytometric assay for the detection of thyroid cancer related hsa-miR-221-3p in blood and tissues.

Analyst 2021 Feb 7;146(3):842-847. Epub 2020 Dec 7.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

In vitro detection of low abundance biomolecules including microRNAs (miRNAs) is essential to biological research and early clinical diagnosis. In this work, a versatile magnetic bead (MB)-based flow cytometric assay was developed for the detection of hsa-miR-221-3p, which is strongly associated with papillary thyroid carcinoma (PTC). In the presence of hsa-miR-221-3p, the complementary DNA probe attached to the surface of MBs is hybridized with the target to form DNA/RNA heteroduplexes. Read More

View Article and Full-Text PDF
February 2021

Late-onset distant metastases confer poor prognosis in patients with well-differentiated thyroid cancer.

Gland Surg 2020 Oct;9(5):1857-1866

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Distant metastases from well-differentiated thyroid carcinoma (WDTC) occasionally occur over a wide range of time intervals after primary thyroid surgery. The prognostic impact of the timing of distant metastasis onset remains unclear.

Methods: We retrospectively reviewed the clinicopathologic features and clinical outcomes of 57 patients with WDTC and distant metastases, and evaluated the mutational profiles of , , and promoter genes. Read More

View Article and Full-Text PDF
October 2020

Effects of the Minimal Extrathyroidal Extension on Early Response Rates after (Adjuvant) Initial Radioactive Iodine Therapy in PTC Patients.

Cancers (Basel) 2020 Nov 13;12(11). Epub 2020 Nov 13.

Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.

Background: Extrathyroidal extension of differentiated thyroid cancer is a poor outcome factor but seems to be less significant in minimal extrathyroidal extension (mETE). However, the impact of mETE on response rate after (adjuvant) initial radioactive iodine (RAI) therapy remains unclear. We therefore compared response rates of patients with classical and follicular variants of papillary thyroid cancer (PTC) according to the updated eighth tumor-node-metastasis (TNM) classification to a control group. Read More

View Article and Full-Text PDF
November 2020