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    Impact of the Reclassification of the Non-Invasive Follicular Variant of Papillary Carcinoma as Benign on the Malignancy Risk of the Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis Study.
    Acta Cytol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, USA.
    Objectives: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) established diagnostic categories for cytologic specimens of the thyroid. Each category was associated with an estimated risk of malignancy. Recently, the non-invasive follicular variant of papillary thyroid carcinoma has been reclassified as benign. Read More

    Metastatic Follicular Thyroid Carcinoma and the Primary Thyroid Gross Examination: Institutional Review of Cases from 1990 to 2015.
    Endocr Pathol 2017 Apr 25. Epub 2017 Apr 25.
    Pathology Service, WRN219, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
    The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less than a millimeter of tissue segregating them from adenomas and non-invasive follicular thyroid neoplasms with papillary-like nuclear features, opinions vary internationally over how much of the capsule to submit in order to deem it well enough represented, considering that even if grossly entirely submitted in microcassettes, without leveling through each tissue block, the capsule is truly never entirely examined microscopically. Here, we retrospectively examine submission practices and outcomes at a single, high-volume institution over a 25-year period. Read More

    Association between Hashimoto's Thyroiditis and Thyroid Cancer in 64,628 Patients.
    Front Oncol 2017 10;7:53. Epub 2017 Apr 10.
    Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Background: The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL). Read More

    Aberrant Intrathyroid Tissue: a Report of Intrathyroid Lymph Node Metastasis and a Review of Literature.
    Indian J Surg 2017 Apr 20;79(2):148-152. Epub 2017 Jan 20.
    Department of Surgery, Waikato Hospital, Hamilton, New Zealand.
    Aberrant histological elements have been infrequently reported to exist within the intact thyroid gland. In addition to distant metastases to the thyroid, a number of ectopic tissue rests and unusual cysts have been described within the thyroid gland. In this article, we report the presence of a true intrathyroid lymph node and describe the first reported case of intrathyroid lymph node metastasis of papillary thyroid cancer. Read More

    Parotid gland involvement as an initial presentation of papillary thyroid carcinoma.
    Int J Oral Maxillofac Surg 2017 Apr 22. Epub 2017 Apr 22.
    Department of Pathology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
    Papillary thyroid carcinoma (PTC) is the most differentiated malignant thyroid neoplasm. Local metastases of PTC commonly occur in the regional lymph nodes, while distant metastases are mainly to the lung and bone. The case of a patient with PTC who presented with swelling of the parotid gland and neck, mimicking a primary parotid neoplasm, is presented herein. Read More

    [Clinical analysis of seven cases of pulmonary malignant tumors in children].
    Zhonghua Er Ke Za Zhi 2017 Apr;55(4):298-303
    Department of Pulmonology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China.
    Objective: To understand the clinical manifestation, imaging characteristics and outcomes of pulmonary malignant tumors in children. Method: We retrospectively collected information about seven cases of pulmonary malignant tumors in children in our hospital from Jan 2010 to Dec 2016. The information included clinical manifestation, imaging characteristics, pathologic results, and treatment. Read More

    [Factors for lymph node metastasis and survival rate in papillary thyroid microcarcinoma: from a large cohort of 3 607 cases series].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Apr;52(4):267-272
    Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.
    Objective: To investigate high-risk factors for lymph node metastasis (LNM) and 10-year survival rate in patients with papillary thyroid microcarcinoma (PTMC). Methods: We retrospectively analyzed the clinical data of 3 607 patients with PTMC received surgery in our hospital from January 2005 to December 2015. Univariate and multivariate analyses were performed to identify the factors associated with metastasis and 10-year survival rate of the patients was calculated. Read More

    [Prediction of occult carcinoma in contralateral nodules based on the ultrasonic features of unilateral papillary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Apr;52(4):259-262
    Department of Diagnostic Ultrasound, Sir Run Run Shaw Hospital of Zhejiang University College of Medicine &Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou 310016, China.
    Objective: To investigate the occurrence of occult carcinoma in contralateral lobes based on the ultrasonic features of unilateral papillary thyroid carcinoma. Methods: The study included 202 consecutives cases of unilateral papillary thyroid carcinoma with benign nodules in the contralateral lobe identified by preoperative ultrasound or fine-needle aspiration from June 2014 to December 2015. All patients received total thyroidectomies, and with postoperative pathological examination they were divided into two groups, one including 60 cases with positive occult cancer and another one consisting of 142 cases with negative occult cancer. Read More

    Immunohistochemical detection of the BRAF V600E mutation in papillary thyroid carcinoma. Evaluation against real-time polymerase chain reaction.
    Endocrinol Diabetes Nutr 2017 Feb 10;64(2):75-81. Epub 2017 Feb 10.
    Servicio de Endocrinología, Hospital Universitario de Basurto, Bilbao, España.
    Introduction: The BRAF V600E mutation is the most common genetic change in papillary thyroid carcinoma and is associated with a poorer clinical course. Usual methods for its study (DNA sequencing or molecular test based on PCR) are expensive and time-consuming. Recently, immunohistochemistry (IHC) for BRAF mutation has been introduced. Read More

    Striated duct adenoma presenting with intra-tumoral hematoma and papillary thyroid carcinoma-like histology.
    Pathol Int 2017 Apr 25. Epub 2017 Apr 25.
    Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
    Striated duct adenoma of the salivary gland is a rare benign tumor characterized by unilayered duct epithelium and striations of the tumor cell membranes. To the best of our knowledge, only six cases have been reported in the literature. Here we report an additional case, which was complicated by an intra-tumoral hematoma on clinical presentation and by papillary thyroid carcinoma-like histology on intra-operative frozen section diagnosis. Read More

    Micronuclei and nuclear buds: Highlighting overlooked indicators of chromosomal damage in thyroid aspiration smears.
    Diagn Cytopathol 2017 Apr 24. Epub 2017 Apr 24.
    Department of Pathology, Gayrettepe Florence Nightingale Hospital, Istanbul Bilim University, Istanbul, Turkey.
    Background: We aimed to examine the diagnostic utility of micronuclei (MN) and nuclear buds (NBs) in aspiration smears of the well-differentiated epithelial lesions of thyroid.

    Methods: One hundred five cases composed of 34 follicular nodular disease (FND), 31 Hashimoto's thyroiditis (HT), and 40 papillary thyroid carcinoma (PTC) were compiled retrospectively. May- Grünwald Giemsa (MGG) stained smears of each case were selected to count cells with nuclear protrusions (NPs) per 1000 cells. Read More

    Age-based disparities in the use of total thyroidectomy for papillary thyroid carcinoma.
    Clin Transl Oncol 2017 Apr 24. Epub 2017 Apr 24.
    Department of Surgery, The Everett Clinic, Medical Office Building, 1330 Rockefeller Avenue, Everett, WA, 98201, USA.
    Background: Elderly patients may be less likely than younger patients to receive indicated therapy. We hypothesized that older patients with papillary thyroid carcinoma (PTC) would be less likely to receive total thyroidectomy (TT) than their younger counterparts.

    Materials And Methods: The Surveillance, Epidemiology, and End Results database were queried for adult patients diagnosed with PTC from 2000 through 2009. Read More

    Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia.
    World J Clin Oncol 2017 Apr;8(2):151-157
    Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Department of Endocrinology, Prince Sultan Military Medical City, Riyadh 11342, Saudi Arabia.
    Aim: To stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system.

    Methods: From January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients (15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. All thyroid cyto-pathological slides and ultra sound reports were reviewed and classified according to the Bethesda System for Reporting Thyroid Cytopathology. Read More

    T cell receptor β-chain repertoire analysis reveals the association between neoantigens and tumour-infiltrating lymphocytes in multifocal papillary thyroid carcinoma.
    Int J Cancer 2017 Apr 21. Epub 2017 Apr 21.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Head & Neck Surgery, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing, 100142, China.
    To explore whether a few non-synonymous somatic mutations could induce activation and proliferation of neoantigen-specific tumour-infiltrating lymphocytes (TILs) in tumours with low mutation rates, we analysed a patient with multifocal papillary thyroid carcinoma (seven non-contiguous cancer foci) to investigate the relationship between neoantigens and TILs. These seven foci had a few or no non-synonymous somatic mutations; moreover, multiple loci had similar or different spectra of mutations. We used high-throughput sequencing of the rearranged genes in T cell receptor β-chain (TCRβ) to reveal the basic characteristics of T cells in seven tumour foci and matched adjacent normal tissue. Read More

    The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population.
    Oncotarget 2017 Apr 6. Epub 2017 Apr 6.
    Oncology Clinic, Holycross Cancer Centre, Kielce, Poland.
    Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p. Read More

    The Effectiveness of Prophylactic Modified Neck Dissection for Reducing the Development of Lymph Node Recurrence of Papillary Thyroid Carcinoma.
    World J Surg 2017 Apr 20. Epub 2017 Apr 20.
    Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-dori, Chuo-ku, Kobe, 650-0011, Japan.
    Aim: The most frequent recurrence site of papillary thyroid carcinoma (PTC) is the cervical lymph nodes. The introduction of an electric linear probe for use with ultrasonography in 1996 improved preoperative lateral neck evaluations. Before 2006, however, our hospital routinely performed prophylactic modified neck dissection (p-MND) for N0 or N1a PTCs >1 cm to prevent node recurrence. Read More

    miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
    Oncotarget 2017 Mar 3. Epub 2017 Mar 3.
    Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116044, Liaoning Province, China.
    Follicular thyroid carcinoma (FTC) is a more aggressive form of thyroid cancer than the common papillary type. Alpha-2,8-sialyltransferase (ST8SIA) family members are expressed in various cancers and may be associated with FTC progression. In this study, we measured ST8SIA family expression in two FTC cell lines with different invasive potentials (FTC-133 and FTC-238) and Nthy-ori 3-1 cell lines, as well as FTC and normal thyroid tissues. Read More

    Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma.
    Pol Arch Intern Med 2017 Apr 20. Epub 2017 Apr 20.
    INTRODUCTION    Papillary thyroid carcinoma (PTC) is a well-differentiated tumor that occurs in several histological variants whose biological behaviors remain unclear. Angiogenesis and lymphangiogenesis are critical processes that enable tumor progression.  OBJECTIVES    The purpose of this study was to evaluate the angiogenic and lymphangiogenic phenotypes of PTC considering the differences between histological variants. Read More

    Importance of cytological subclassification of thyroid nodules with Bethesda category III cytology (AUS/FLUS) into architectural atypia only and nuclear atypia: A prospective study.
    Diagn Cytopathol 2017 Apr 19. Epub 2017 Apr 19.
    Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    Background: The objective of this study was to compare two cytological subcategories of thyroid nodules with Bethesda category III initial cytology.

    Methods: This was a prospective study. All patients with thyroid nodules > 1 cm were eligible and 98 patients with category III cytology were selected. Read More

    Hyalinizing trabecular tumour of the thyroid: fine-needle aspiration cytological diagnosis and correlation with histology.
    J Clin Pathol 2017 Apr 19. Epub 2017 Apr 19.
    Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, Lausanne, Switzerland.
    Hyalinizing trabecular tumour (HTT) is a rare thyroid neoplasm of follicular cell origin characterised by a trabecular growth pattern and prominent intratrabecular and intertrabecular hyalinisation. These peculiar histological features allow the prompt recognition of this neoplasm in surgical specimens. However, cytological diagnosis of HTT remains elusive and misleading because of overlapping characteristics with other thyroid tumours, particularly papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC) and the newly described non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Read More

    HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.
    Oncotarget 2017 Mar;8(12):19843-19854
    Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
    Redifferentiation therapy with BRAF/MEK inhibitors to facilitate treatment with radioiodine represents a good choice for radioiodine-refractory differentiated thyroid carcinoma, but recent initial clinical outcomes were modest. MAPK rebound caused by BRAF/MEK inhibitors-induced activation of HER2/HER3 is a resistance mechanism, and combination with HER inhibitor to prevent MAPK rebound may sensitize BRAFV600E-mutant thyroid cancer cells to redifferentiation therapy. To evaluate if inhibiting both BRAF/MEK and HER can produce stronger redifferetiation effect, we tested the effects of BRAF/MEK inhibitor dabrafenib/selumetinib alone or in combination with HER inhibitor lapatinib on the expression and function of iodine- and glucose-handling genes in BRAFV600E-positive BCPAP and K1 cells, using BHP 2-7 cells harboring RET/PTC1 rearrangement as control. Read More

    Hobnail variant of papillary thyroid carcinoma: molecular profiling and comparison to classical papillary thyroid carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma.
    Oncotarget 2017 Mar;8(13):22023-22033
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Background: As a rare but aggressive papillary thyroid carcinoma (PTC) variant, the genetic changes of hobnail variant of PTC (HVPTC) are still unclear.

    Results: The prevalence of HVPTC was 1.69% (18/1062) of all PTC diagnosed in our cohort. Read More

    Hobnail variant of papillary thyroid carcinoma: A case with an unusual presentation.
    Diagn Cytopathol 2017 Apr 16. Epub 2017 Apr 16.
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
    Variants of papillary thyroid carcinoma (PTC) account for up to 25% of the cases, some of which are proven to be associated with aggressive clinical behavior such as tall cell and columnar cell variants. Hobnail variant of PTC (HVPTC) is recently described as a rare and aggressive variant of PTC. Herein, we are reporting a case of HVPTC in a patient who presented with hemoptysis and an intratracheal blood clot that was aspirated and submitted for cytopathological examination. Read More

    Diagnostic Limitation of Fine-Needle Aspiration (FNA) on Indeterminate Thyroid Nodules Can Be Partially Overcome by Preoperative Molecular Analysis: Assessment of RET/PTC1 Rearrangement in BRAF and RAS Wild-Type Routine Air-Dried FNA Specimens.
    Int J Mol Sci 2017 Apr 12;18(4). Epub 2017 Apr 12.
    Department of Surgery, Konkuk University School of Medicine, Seoul KS013, Korea.
    Molecular markers are helpful diagnostic tools, particularly for cytologically indeterminate thyroid nodules. Preoperative RET/PTC1 rearrangement analysis in BRAF and RAS wild-type indeterminate thyroid nodules would permit the formulation of an unambiguous surgical plan. Cycle threshold values according to the cell count for detection of the RET/PTC1 rearrangement by real-time reverse transcription-polymerase chain reaction (RT-PCR) using fresh and routine air-dried TPC1 cells were evaluated. Read More

    Endoscopic Central Lymph Node Dissection via Breast Combined with Oral Approach for Papillary Thyroid Carcinoma: A Preliminary Study.
    World J Surg 2017 Apr 17. Epub 2017 Apr 17.
    Department of General Surgery, Zhongshan Hospital Affiliated with Xiamen University, Xiamen, 361004, Fujian, China.
    Objective: To investigate the feasibility and necessity of endoscopic thyroidectomy with central lymph node dissection via the combined breast and trans-oral approaches.

    Methods: Six patients with papillary thyroid carcinoma who underwent endoscopic total thyroidectomy with central node dissection via combined breast and trans-oral approaches from November 2014 to January 2015 in Zhongshan Hospital, Xiamen University, were analyzed.

    Results: After completion of endoscopic central lymph node dissection via the traditional breast approach, eight pieces of lymph nodes could still be dissected via the trans-oral approach. Read More

    Differential diagnostic significance of HBME-1, CK19 and S100 in various thyroid lesions.
    Malays J Pathol 2017 Apr;39(1):55-67
    Sanjay Gandhi Post-graduate Institute of Medical Sciences, Department of Pathology, C-Block, Rae Bareli Road, Lucknow, Uttar Pradesh, India. Pin 226014.
    Objective: Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions.

    Materials And Methods: Immunohistochemical analysis of 60 thyroidectomy specimens (10 hyperplastic nodules, 14 follicular adenomas and 36 malignant thyroid neoplasms) was carried out. Read More

    Nuclear morphometry and texture analysis on cytological smears of thyroid neoplasms: a study of 50 cases.
    Malays J Pathol 2017 Apr;39(1):33-37
    Hindu Rao Hospital, Department of Pathology, Malka Ganj, Delhi - 110007, India.
    Background: Fine needle aspiration cytology (FNAC) is a reliable and reproducible diagnostic technique for thyroid lesions with certain limitations. Computed morphometric methods have been introduced with a view to improve the diagnostic yield of thyroid aspirates. However, a review of the existing literature revealed conflicting reports regarding morphometric parameters in thyroid neoplasms. Read More

    HSP90 inhibitor NVP-AUY922 induces cell apoptosis by disruption of the survivin in papillary thyroid carcinoma cells.
    Biochem Biophys Res Commun 2017 Apr 13. Epub 2017 Apr 13.
    Department of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang 110001, Liaoning Province, People's Republic of China. Electronic address:
    Heat shock protein 90 (HSP90) is a molecular chaperone required for maintaining the stability and function of signal proteins that plays an important role in promoting the growth and survival of cancer cells. The incidence of papillary thyroid carcinoma (PTC) has been increasing in recent years. The effect of the novel non-geldanamycin HSP90 inhibitor NVP-AUY922 on apoptosis of papillary thyroid carcinoma cells has not been investigated. Read More

    Expression of MRP1 and ABCG2 is associated with adverse clinical outcomes of the papillary thyroid carcinoma with a solid component.
    Hum Pathol 2017 Apr 11. Epub 2017 Apr 11.
    Department of Diagnostic Pathology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
    Solid variant of papillary thyroid carcinoma is characterized by a solid component (SC) retaining classical cytological features of papillary thyroid carcinoma (PTC). Despite some controversies, PTC cases with SC (PTCSC) have poor prognosis compared to well-differentiated PTC. We investigated if cancer stem cells (CSC) may have a role in pathogenesis of PTCSC. Read More

    Improving Access to Image-guided Procedures at an Integrated Rural Critical Access Hospital: Ultrasound-guided Thyroid Biopsy Program.
    Curr Probl Diagn Radiol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Critical access hospitals face difficulty providing all services locally and may need to refer patients off-site for additional care. Providing on-site minimally invasive biopsies, may obviate visits to tertiary or quaternary care centers. This study aims to assess feasibility and outcomes of an ultrasound-guided thyroid biopsy program in a critical access hospital. Read More

    Role of prophylactic central neck dissection in clinically node-negative differentiated thyroid cancer: assessment of the risk of regional recurrence.
    Updates Surg 2017 Apr 13. Epub 2017 Apr 13.
    Division of General Surgery and Surgical Oncology, School of Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italy.
    Prophylactic central neck dissection in clinically node-negative patients remains controversial. The aim of this multicenter retrospective study was to determine the rate of metastases in the central neck in clinically node-negative differentiated thyroid cancer patients, to examine the morbidity, and to assess the risk of regional recurrence in patients treated with total thyroidectomy with concomitant bilateral or ipsilateral central neck dissection compared with those undergoing total thyroidectomy alone. 258 consecutive clinically node-negative patients were divided into three groups according to the procedures performed: total thyroidectomy only (group A), total thyroidectomy with concomitant ipsilateral central neck dissection (group B), and total thyroidectomy combined with bilateral central neck dissection (group C). Read More

    Radioguided occult lesion localization for locally recurrent thyroid carcinoma.
    Eur Arch Otorhinolaryngol 2017 Apr 13. Epub 2017 Apr 13.
    Department of Nuclear Medicine, Ankara Oncology Training and Research Hospital, Ankara, Turkey.
    The aim of this study was to present our experiences with patients operated on for the recurrence of papillary thyroid cancer with the combined use of preoperative ultrasonographic mapping and radioguided occult lesion localization (ROLL). Twenty patients who had already undergone total thyroidectomy and central/lateral neck dissection for papillary thyroid carcinoma were reoperated on due to locoregional metastasis. The patients with proven recurrences and high Tg wash-out levels in cytopathologic aspirates were operated on. Read More

    Low grade mucoepidermoid tumor of Parotid gland presenting as focal asymmetry in the follow-up Radioiodine scan in a patient of differentiated papillary carcinoma of thyroid.
    J Nucl Med Technol 2017 Apr 13. Epub 2017 Apr 13.
    RADIATION MEDICINE CENTRE (BARC), Tata Memorial Hospital Annexe, India.
    Low grade mucoepidermoid tumor of the right parotid gland presenting as focal uptake in the follow-up whole body iodine scan in a patient of differentiated papillary carcinoma of thyroid 1 year after successful ablation is presented in this report. Following surgical excision, the histopathology was proven. The illustrated case represents false positive focal accumulation of (131)I in low grade mucoepidermoid carcinoma of the salivary gland that arose early in the follow-up course in differentiated thyroid carcinoma post-radioiodine (RAI). Read More

    Management of PET diagnosed thyroid incidentalomas in British Columbia Canada: Critical importance of the PET report.
    Am J Surg 2017 Mar 24. Epub 2017 Mar 24.
    Department of Surgery, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, V6Z 1Y6, Canada. Electronic address:
    Background: PET diagnosed thyroid incidentalomas (TI) should undergo prompt evaluation due to a high risk of underlying malignancy. Our study reviewed physician management of PET diagnosed TIs in British Columbia (BC), Canada.

    Methods: All PET reports from BC between 2011 and 2014 were reviewed. Read More

    Risk of Malignancy and Risk of Neoplasia in the Bethesda Indeterminate Categories: Study on 4,532 Thyroid Fine-Needle Aspirations from a Single Institution in India.
    Acta Cytol 2017 Apr 14. Epub 2017 Apr 14.
    Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Objectives: To determine the frequency of category 3 (atypia of undetermined significance [AUS]/follicular lesion of undetermined significance [FLUS]), category 4 (follicular neoplasm), and category 5 (suspicious for malignancy) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the risk of malignancy (ROM) and the risk of neoplasia (RON) in these categories.

    Study Design: A retrospective 6-year audit of 4,532 thyroid fine-needle aspirations (FNA) reported as per the TBSRTC from a single institution with cytohistological correlation in 335 cases.

    Results: The frequency of categories 3, 4, and 5 was 2. Read More

    Surgical management of papillary thyroid carcinoma: an overview.
    Updates Surg 2017 Apr 12. Epub 2017 Apr 12.
    Division of Endocrine Surgery, Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy.
    The surgical management of papillary thyroid carcinoma remains contentious and the optimal surgical strategy has not been yet established. The extent of thyroid resection has been the nub of this debate. Literature lacks prospective randomized controlled trials that could help put this debate to rest, and these have been labeled as being impractical. Read More

    Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer.
    Oncotarget 2017 Feb 23. Epub 2017 Feb 23.
    Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University, Tokyo, Japan.
    Glycans containing α-L-fucose participate in diverse interactions between cells and extracellular matrix. High glycan expression on cell surface is often associated with neoplastic progression. The lysosomal exoenzyme, α-L-fucosidase-1 (FUCA-1) removes fucose residues from glycans. Read More

    miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis.
    Oncotarget 2017 Mar 29. Epub 2017 Mar 29.
    Department of Breast and Thyroid Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.
    Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. Read More

    HABP2 p.G534E variant in patients with family history of thyroid and breast cancer.
    Oncotarget 2017 Mar 29. Epub 2017 Mar 29.
    CIPE - International Research Center, A. C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
    Familial Papillary Thyroid Carcinoma (PTC) has been described as a hereditary predisposition cancer syndrome associated with mutations in candidate genes including HABP2. Two of 20 probands from families with history of PTC and breast carcinoma (BC) were evaluated by whole exome sequencing (WES) revealing HABP2 p.G534E. Read More

    Single-Incision, Gasless, Endoscopic Trans-Axillary Total Thyroidectomy: A Feasible and Oncologic Safe Surgery in Patients with Papillary Thyroid Carcinoma.
    J Laparoendosc Adv Surg Tech A 2017 Apr 12. Epub 2017 Apr 12.
    1 Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine , Seoul, Republic of Korea.
    Background: The aim of this study is to compare the feasibility and oncologic safety of Single-incision, gasless, Endoscopic trans-axillary bilateral Total thyroidectomy (SET) with open cervical total thyroidectomy in patients with papillary thyroid carcinoma (PTC).

    Materials And Methods: From March 2008 to December 2012, PTC patients underwent bilateral total thyroidectomy. Conventional, open surgery was performed on 538 patients (Group O) and endoscopic surgery was performed on 200 patients (Group E). Read More

    Chinese data of efficacy of low- and high-dose of iodine-131 for the ablation of thyroid remnant.
    Thyroid 2017 Apr 12. Epub 2017 Apr 12.
    Xin Hua Hospital, Shanghai Jiaotong University, School of Medicine, Department of Nuclear Medicine , Kongjiang 1665 , Shanghai, China , 200092 ;
    Background: Chinese data of efficacy of low- and high-dose of radioiodine for thyroid remnant is still absent. The aim of the study is to investigate whether the low-dose of radioiodine is as effective as high-dose for remnant ablation in Chinese patients.

    Methods: Patients presenting for radioiodine ablation in our department were included. Read More

    Sonographic differences between conventional and follicular variant papillary thyroid carcinoma.
    Eur Arch Otorhinolaryngol 2017 Apr 10. Epub 2017 Apr 10.
    Department of Otolaryngology, Head and Neck Surgery, South Infirmary Victoria University Hospital, Cork, Ireland.
    Follicular variant papillary thyroid carcinoma (FVPTC) may pose a diagnostic challenge due to higher likelihood of lower risk cytology compared to conventional papillary thyroid carcinoma (CPTC). Recent guidelines have recommended the use of sonographic features to guide decisions to biopsy thyroid nodules. The purpose of this study was to evaluate the sonographic features of CPTC and FVPTC. Read More

    Usefulness of Stereotactic Radiotherapy Using CyberKnife for Recurrent Lymph Node Metastasis of Differentiated Thyroid Cancer.
    Case Rep Endocrinol 2017 15;2017:7956726. Epub 2017 Mar 15.
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
    A woman in her 60s presented with a recurrent lymph node metastasis from a papillary thyroid carcinoma in the right parapharyngeal space. She had already undergone total thyroidectomy, five resections for cervical lymph node metastases, and right carotid rebuilding. Surgical resection of the current metastasis was impossible. Read More

    Surveillance Neck Sonography After Thyroidectomy for Papillary Thyroid Carcinoma: Pitfalls in the Diagnosis of Locally Recurrent and Metastatic Disease.
    J Ultrasound Med 2017 Apr 10. Epub 2017 Apr 10.
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    A sonographic examination of the neck performed 6 to 12 months after thyroid surgery in patients with differentiated thyroid cancer is strongly recommended by the American Thyroid Association and considered mandatory by the European Thyroid Association for locoregional surveillance. The aim of this article is to review the normal anatomic changes expected after thyroid surgery and the pathologic mimics of thyroid carcinoma recurrence in post-thyroidectomy patients as they appear on neck sonography. We hope to offer some pearls to increase diagnostic confidence in this setting. Read More

    MicroRNA-based molecular classification of papillary thyroid carcinoma.
    Int J Oncol 2017 May 7;50(5):1767-1777. Epub 2017 Apr 7.
    Department of Internal Medicine and Medical Specialties, 'Sapienza' University of Rome, Rome, Italy.
    MicroRNA (miRNA) expression is dysregulated in many human malignancies, and a growing number of studies are focused on their potential use as tumor biomarkers. To identify a miRNA signature for papillary thyroid carcinomas (PTC), we investigated miRNA expression profiles in two independent cohorts of PTCs, which included major histological subtypes [classical-type (PTC‑CT), follicular-variant (PTC‑FV), and tall-cell variant (PTC‑TCV)] and cases with low or intermediate risk of recurrence. Using TaqMan® Array Human MicroRNA A+B Cards v3. Read More

    Runt-related transcription factor 2 (Runx2) is responsible for galectin-3 overexpression in human thyroid carcinoma.
    J Cell Biochem 2017 Apr 8. Epub 2017 Apr 8.
    Istanbul University, Faculty of Science Department of Biology, 34134 Vezneciler, Istanbul, Turkey.
    Runx2 promotes metastatic ability of cancer cells by directly activating some of the mediators regarding malignancy. Galectin-3 (Gal-3) extensively expressed in normal and transformed cells and it is responsible for many cellular processes. In this study, we aimed to investigate whether there is any relationship between runx2 transcription factor and regulation of galectin-3 expression in different human thyroid carcinoma cell lines. Read More

    Modeling therapeutic response to radioiodine in metastatic thyroid cancer: a proof-of-concept study for individualized medicine.
    Oncotarget 2017 Mar 29. Epub 2017 Mar 29.
    Service de Médecine Nucléaire, CHU La Timone, Aix-Marseille Université, 13385 Marseille 05, France.
    Purpose: Radioiodine therapy (RAI) has traditionally been used as treatment for metastatic thyroid cancer, based on its ability to concentrate iodine. Propositions to maximize tumor response with minimizing toxicity, must recognize the infinite possibilities of empirical tests. Therefore, an approach of this study was to build a mathematical model describing tumor growth with the kinetics of thyroglobulin (Tg) concentrations over time, following RAI for metastatic thyroid cancer. Read More

    [A Familial Non Medullary Thyroid Carcinoma (FNMTC) : a clinical and genetic update].
    Rev Med Liege 2016 Dec;71(12):557-561
    Service d'Endocrinologie, CHU de Liège, Site du Sart Tilman, Liège, Belgique.
    The syndrome of Familial Non Medullary Thyroid Carcinoma (FNMTC) includes two or more patients with an isolated non-medullary thyroid cancer (papillary, follicular, anaplastic) within the same family. To diagnose FNMTC, the clinician must exclude a syndromic presentation such as the syndromes of Cowden, Gardner or Werner, and the Carney Complex. Up to now, a hundred families with FNMTC have been genetically studied, including forms with (Ch19p13. Read More

    A Case Report on Multiple Stones in the Thyroid Gland in Association with Sclerosing Thyroiditis: An Unusual Encounter.
    J Clin Diagn Res 2017 Feb 1;11(2):PD01-PD03. Epub 2017 Feb 1.
    Associate Professor and Unit Chief, Department of General Surgery, Rajendra Institute of Medical Sciences , Ranchi, Jharkhand, India .
    Stones are very frequently found in the gallbladder and urinary tract. Rarely the thyroid gland can be a site for stone formation. Few cases of calcification in thyroid gland have been described in the medical literature in association with papillary carcinoma and multinodular goiter. Read More

    CD70 and PDL1 in anaplastic thyroid cancer -NDASH-promising targets for immunotherapy.
    Histopathology 2017 Apr 6. Epub 2017 Apr 6.
    Department of Pathology, Antwerp University Hospital, Wilrijkstaat 10, 2650, Edegem, Belgium.
    Aims: Over the last years, immune checkpoint inhibition has proven to be effective in several solid malignancies. The aim of this study was to identify novel targets for immunotherapy in anaplastic thyroid cancer by analysis of the expression of tumor antigens for which therapeutic agents are available.

    Method And Results: By immunohistochemistry we observed tumoral expression of CD70 in 49% of cases. Read More

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