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    15426 results match your criteria Thyroid Papillary Carcinoma

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    Malignant tumors associated with ovarian mature teratoma: A single institution experience.
    Pathol Res Pract 2017 Jan 22. Epub 2017 Jan 22.
    Department of Gynecology and Obstetrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
    Objective: The aims of this study are to present demographical features of cases diagnosed with malignant tumor associated with ovarian mature teratoma and to analyze histopathological features and clinical follow up of these tumors.

    Study Design: Single-institution retrospective charts were reviewed to identify all cases of ovarian mature teratoma diagnosed from 1998 to 2015. Clinicopathological parameters that were analyzed include age, tumor size, tumor stage, histological type, laterality, IOC diagnosis and whether or not patient has received adjuvant chemotherapy. Read More

    Diagnostic utility of CK19 and CD56 in the differentiation of thyroid papillary carcinoma from its mimics.
    Pathol Res Pract 2017 Jan 22. Epub 2017 Jan 22.
    Department of Pathology,Ahmed Maher Teaching Hospital, Cairo, Egypt.
    Background: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. Read More

    The relationship between BRAFV600E, NF-κB and TgAb expression in papillary thyroid carcinoma.
    Pathol Res Pract 2017 Jan 12. Epub 2017 Jan 12.
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China. Electronic address:
    Purpose: The aim of this study was to investigate the potential link between thyroglobulin antibody (TgAb) titers and papillary thyroid carcinoma (PTC) aggressiveness.

    Materials And Methods: This retrospective study included 122 patients who had undergone total thyroidectomy and neck central area lymph dissection followed by radioactive iodine (RAI) ablation for PTC between July 2012 and July 2014. The parameters included clinical characteristics of PTC, TgAb levels and tumor histopathological characteristics. Read More

    Expression of BMP-4 in papillary thyroid carcinoma and its correlation with tumor invasion and progression.
    Pathol Res Pract 2017 Jan 17. Epub 2017 Jan 17.
    Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China. Electronic address:
    Bone morphogenetic protein 4 (BMP-4) is a member of the BMP protein family. BMP-4 was reported to induce epithelial-mesenchymal transition (EMT) and promote tumor cell immigration and invasion. This study aimed to investigate the expression of BMP-4 in papillary thyroid carcinoma (PTC) and its correlation with the patients' clinicophathological features and with tumor invasion and metastasis. Read More

    Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.
    Oncologist 2017 Feb 16. Epub 2017 Feb 16.
    Foundation Medicine, Cambridge, Massachusetts, USA.
    Background: Thyroid carcinoma, which is rare in pediatric patients (age 0-18 years) but more common in adolescent and young adult (AYA) patients (age 15-39 years), carries the potential for morbidity and mortality.

    Methods: Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements. This PAYA data series includes 41 patients with papillary thyroid carcinoma (PTC), 3 with anaplastic thyroid carcinoma (ATC), and 14 with medullary thyroid carcinoma (MTC). Read More

    Papillary thyroid microcarcinoma: the significance of high risk features.
    BMC Cancer 2017 Feb 16;17(1):142. Epub 2017 Feb 16.
    Department of Surgery, St. Paul's Hospital & University of British Columbia, St. Paul's Hospital Department of Surgery, Room C303, Burrard Building, 1081 Burrard Street, Vancouver, V6Z 1Y6, BC, Canada.
    Background: Papillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. Read More

    Study of Immunohistochemical Markers (CK-19, CD-56, Ki-67, p53) in Differentiating Benign and Malignant Solitary Thyroid Nodules with special Reference to Papillary Thyroid Carcinomas.
    J Clin Diagn Res 2016 Dec 1;10(12):EC14-EC19. Epub 2016 Dec 1.
    Post Graduate Student, Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital , Pune, Maharashtra, India .
    Introduction: Solitary Thyroid Nodule (STN) has provoked increased concern owing to higher incidence of malignancy. The inter and intra observer variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas (PTC) may sometimes pose a diagnostic difficulty.

    Aim: This study was undertaken to analyse immunohistochemical (IHC) markers (CK-19, CD-56, p53, Ki-67) to differentiate between benign and malignant surgically resected STN along with their utility in the identification of PTC. Read More

    Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression.
    PLoS One 2017 16;12(2):e0167782. Epub 2017 Feb 16.
    Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
    Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat Protein (NRARP) have been implicated in oncogenesis of many cancers, but the roles in PTCs are less studied. In this study, we show that NRARP is frequently over-expressed in thyroid carcinoma. Read More

    Synchronous papillary thyroid carcinoma and breast ductal carcinoma: A rare case report and literature review.
    Medicine (Baltimore) 2017 Feb;96(7):e6114
    aDepartment of Pathology, West China Hospital of Sichuan University bThyroid and Parathyroid Surgery Group, West China Hospital of Sichuan University, Chengdu 610041, China.
    Background: The incidences of both thyroid cancer and breast cancer have been rising in recent years; however, it is very rare to find a single person with both of these cancers. Only a few cases of synchronous thyroid and breast cancer have been published, and even fewer cases have been reported in older patients (>60 years).

    Case Summary: The current study presents a case of synchronous papillary thyroid carcinoma and breast ductal carcinoma in an elderly patient. Read More

    A rare case report of very low thyroglobulin and a negative whole-body scan in a patient with a solid variant of papillary thyroid carcinoma with distant metastases.
    Medicine (Baltimore) 2017 Feb;96(7):e6086
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China.
    Rationale: The early detection of recurrent differentiated thyroid carcinoma (DTC) cells in postsurgery DTC patients relies on the sensitivity of measuring both the level of thyroglobulin (Tg) and 131-iodine distribution on a whole-body scan (WBS). Recent studies have defined patients who subsequently have no evidence of disease as those who have a stimulated Tg level <1 ng/mL with no other radiological or clinical evidence of disease.

    Patient Concerns: A woman patient with solid variant papillary thyroid carcinoma (SVPTC) had undergone twice thyroidectomy with lymph node dissection and radioactive therapy. Read More

    Cribriform adenocarcinoma of the minor salivary gland arising in the tonsil with metastasis to a cervical lymph node: A case report with description of fine needle aspiration cytology.
    Diagn Cytopathol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Pathology, University of Kansas School of Medicine, Kansas City, Kansas, 66160.
    Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Read More

    The presence of cancerous nodules in lymph nodes is a novel indicator of distant metastasis and poor survival in patients with papillary thyroid carcinoma.
    J Cancer Res Clin Oncol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Thyroid and Breast Surgery, The First Affiliated Hospital of FuJian Medical University, No. 20, Chazhong Road, ChaTing Street, FuZhou City, 350000, FuJian Province, China.
    Purpose: Several characteristics of lymph node metastasis (LNM) as predictors of the risk of recurrence or death were examined in patients with papillary thyroid carcinoma (PTC). The presence of cancerous nodules as a characteristic of LNMs in PTC has not yet been reported. The objective of this study was to evaluate the use of the cancerous nodules in the lymph node (CNLN) to determine the risk of distant metastasis and survival in patients with PTC. Read More

    Histologic Findings and Cytological Alterations in Thyroid Nodules After Radioactive Iodine Treatment for Graves' Disease.
    Int J Surg Pathol 2017 Feb 1:1066896917693091. Epub 2017 Feb 1.
    1 Mount Sinai Medical Center, Miami Beach, FL, USA.
    Unlike the well-documented relation between radiation to the neck and development of papillary thyroid carcinoma, a causal association between radioactive iodine treatment for Graves' disease and development of thyroid malignancy is less defined. However, patients with a background of thyroid dysfunction presenting with clinically palpable thyroid nodules are followed more closely than the average population, and fine needle aspiration is recommended in such circumstances. Cytological examination of aspirates, and histologic examination of tissue provided from patients with a known history of Graves' disease, managed by radioactive iodine therapy can create a diagnostic dilemma, as the distinction between radiation effect and a malignant primary thyroid neoplasm can be very challenging. Read More

    The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma.
    Pancreas 2017 Feb 14. Epub 2017 Feb 14.
    From the *Department of Pathology, Tokyo Metropolitan Geriatric Hospital; †Institute for Integrated Medical Sciences, Tokyo Women's Medical University; ‡Division of Cancer Genomics, National Cancer Center Research Institute; §Department of Endoscopy, Tokyo Metropolitan Geriatric Hospital; ∥Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo; ¶Department of Gastroenterological, General, Breast & Thyroid Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan; #Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
    Objective: We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma.

    Methods: We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenocarcinoma and/or intraductal papillary mucinous neoplasm (mean age, 80.5 years) by submitting the entire pancreas for microscopic examination. Read More

    Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma.
    Cancer 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
    Background: The noninvasive follicular variant of papillary thyroid carcinoma (PTC) has an indolent clinical behavior in comparison with other PTCs, including the invasive follicular variant of papillary thyroid carcinoma (IFVPTC). Recently, the term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced to emphasize the low biological potential of these tumors. This study compares clinical, cytological, and molecular features of NIFTP and IFVPTC. Read More

    Diffuse Follicular Variant of Papillary Thyroid Carcinoma: A Case Report with a Revision of Literature.
    Rare Tumors 2016 Nov 20;8(4):6536. Epub 2016 Dec 20.
    Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Italy.
    The diffuse follicular variant of papillary thyroid carcinoma (DFV-PTC) is a rare malignant thyroid condition. It represents an uncommon variant of papillary carcinoma characterized by a diffuse involvement of thyroid parenchyma, follicular architecture and nuclear features of PTC in absence of a surrounding capsule. Up to date few data have been collected about this entity and, at the best of our knowledge, only 24 cases have been reported in the literature. Read More

    Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway.
    BMC Neurol 2017 Feb 10;17(1):30. Epub 2017 Feb 10.
    Ultrasound Department, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Huang Pu District, Shanghai, Zip code: 200025, People's Republic of China.
    Background: The dysregulation of long noncoding RNAs (lncRNAs) has been identified in a variety of cancers. An increasing number of studies have found the critical role of lncRNAs in the regulation of cellular processes, such as proliferation, invasion and differentiation. Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a novel lncRNA that was primarily detected in papillary thyroid carcinoma. Read More

    A comparative study of nuclear 8-hydroxyguanosine expression in Autoimmune Thyroid Diseases and Papillary Thyroid Carcinoma and its relationship with p53, Bcl-2 and Ki-67 cancer related proteins.
    Adv Med Sci 2016 Jun 22;62(1):45-51. Epub 2016 Jun 22.
    Laboratory of Analysis, Development and Food Safety, Research Group "Biotechnology and Pathology", National School of Engineers of Sfax, Sfax, Tunisia.
    Purpose: To investigate whether the oxidative stress is involved in the evolution of Graves' disease (GD) and Hashimoto thyroiditis (HT) into Papillary Thyroid Carcinoma (PTC), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cancer related proteins (Bcl-2, p53 and Ki-67) expressions were evaluated in these pathologies.

    Patients And Methods: Immunohistochemical method was applied on 25 thyroid tissues. Allred score (AS) serving to evaluate the immunostaining is based on a scale from 0 to 8. Read More

    Expression profile of biomarkers altered in papillary and anaplastic thyroid carcinoma: Contribution of Tunisian patients.
    Bull Cancer 2017 Feb 6. Epub 2017 Feb 6.
    Salah Azaiez Cancer Institute, Department of Immuno-Histo-Cytology Salah Azaiez, Place Bab Saadoun, 1006 Tunis, Tunisia.
    Aims: The objective of this study was to compare the protein expression profile between well-differentiated (papillary) and undifferentiated (anaplastic) thyroid carcinoma in Tunisian patients.

    Methods: This first Tunisian retrospective study concerned data of 38 thyroid cancer cases (19 papillary carcinoma PTC and 19 anaplastic carcinoma ATC) collected at Salah Azaiez Institute of Tunisia. Immunohistochemistry was used to evaluate tumor expression of different molecular markers (p53, Ki67, E-cadherin, cyclin D1, bcl2, S100 and Her-2). Read More

    Prognostic significance of diffuse sclerosing variant papillary thyroid carcinoma: a systematic review and meta-analysis.
    Eur J Endocrinol 2017 Apr;176(4):431-439
    Department of PathologyUniversity of Yamanashi, Yamanashi, Japan.
    Objective: Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is an uncommon variant of papillary thyroid carcinoma (PTC). The biological behaviors and prognostic outcomes of this variant, however, are still controversial. The aim of this systematic review and meta-analysis is to investigate the prognostic significance and outcomes of DSVPTCs in comparison with classical PTCs (cPTCs). Read More

    Evaluation of thyroid nodules classified as Bethesda category III on FNAC.
    J Cytol 2017 Jan-Mar;34(1):5-9
    Department of Pathology, Seth G.S.M.C. and KEM Hospital, Mumbai, Maharashtra, India.
    Background: The Bethesda (BSRTC) category III has been ascribed a malignancy rate of 5-15%, however, the probability of malignancy remains variable.

    Aim: To evaluate category III with respect to its rate and risk of malignancy and substratify it.

    Settings And Design: Atypia of undetermined significance/Follicular lesion of undetermined significance (AUS/FLUS) percentage, cytohistological correlation, and risk of malignancy were analyzed and substratification was done. Read More

    Association between single nucleotide variants of vascular endothelial growth factor a and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population.
    Oncotarget 2017 Feb 2. Epub 2017 Feb 2.
    Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
    The aim of the present study was to investigate whether genetic variants in the vascular endothelial growth factor A gene (VEGFA) were risk factors for papillary thyroid carcinoma (PTC) or nodular goiter (NG) in Han Chinese. A total of 2,319 subjects (861 PTC patients, 562 NG patients, and 896 healthy controls) were included. Five tag single nucleotide polymorphisms (tagSNPs: rs3024997, rs3025040, rs833070, rs25648, and rs10434) in VEGFA were genotyped. Read More

    Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET/CT: A case report.
    Medicine (Baltimore) 2017 Feb;96(6):e5621
    aDepartment of Experimental Medicine bDepartment of Internal Medicine and Clinical Specialities cDepartment of Radiology, Anatomopathology and Oncology, Sapienza University of Rome, Rome dNuclear Medicine Unit, Department of Interventional Oncology, Azienda Ospedaliera Ospedale di Circolo di Busto Arsizio Varese, Busto Arsizio, Varese, Italy.
    Rationale: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).

    Patient Concerns: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC). Read More

    Frequent BRAF (V600E) and Absence of TERT Promoter Mutations Characterize Sporadic Pediatric Papillary Thyroid Carcinomas in Japan.
    Endocr Pathol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Pathology, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
    Pediatric papillary thyroid carcinoma (PTC) has unique features but requires further genetic investigation. Moreover, there has been increasing concern about the risk for pediatric PTC in Japan after the Fukushima accident. This study aims to evaluate the frequencies of BRAF and TERT promoter mutations and to examine their significance in non-radiation-associated pediatric PTCs in Japan. Read More

    The Utility of Intraoperative Frozen Section for The Evaluation of Microscopic Extrathyroidal Extension in Papillary Thyroid Carcinoma.
    Clin Otolaryngol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Otolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Korea.
    Objectives: This study is designed to evaluate the usefulness of intraoperative frozen section for the evaluation of microscopic extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC).

    Design: Retrospective cohort study.

    Setting: Dong-A University Medical Center, Busan, Korea PARTICIPANTS: Three hundred sixty-four patients who underwent thyroid surgery from January 2000 to December 2010, with PTC confined to one unilateral lobe as diagnosed using preoperative ultrasonography were enrolled. Read More

    Clinico-histopathological Survey of Head and Neck Cancer at Tertiary Health Care Centre -Dhulikhel Hospital.
    Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):167-171
    College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan Nepal.
    Background Head and neck is one of the most prevalent site for cancers along with lungs, cervix, breast and stomach. Hospital based cancer registries required for effective evaluation of diagnosis and management of cancer is inadequate in Nepal. Cancer registry system established by WHO is acquired by seven major hospitals in our country. Read More

    Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes.
    Oncotarget 2017 Jan 30. Epub 2017 Jan 30.
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
    Background: EDC1 is a novel type of antibody-drug conjugate which binds and inhibits the Na,K-ATPase on the surface of cancer cells expressing dysadherin. The purpose of this study was to determine the expression of dysadherin in different types of thyroid carcinoma, and evaluate the therapeutic potential of EDC1 for thyroid carcinomas.

    Methods: Thyroid tissues from 158 patients were examined for dysadherin expression and correlation with clinicopathological features. Read More

    Patterns, Predictive Factors, and Prognostic Impact of Contralateral Lateral Lymph Node Metastasis in N1b Papillary Thyroid Carcinoma.
    Ann Surg Oncol 2017 Feb 3. Epub 2017 Feb 3.
    Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Background: Although the incidence among patients with bilateral lateral lymph node metastasis (LLNM) in N1b papillary thyroid carcinoma (PTC) is reported to be as high as 40%, only a few reports have addressed the characteristics of contralateral LLNM. Therefore, this study aimed to investigate the characteristics of patients with contralateral LLNM in N1b PTC.

    Methods: This study retrospectively reviewed 834 patients with N1b PTC who underwent modified radical neck dissection between January 1997 and June 2015. Read More

    Natural history of thyroid cancer [Review].
    Endocr J 2017 Feb 2. Epub 2017 Feb 2.
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
    Thyroid cancers have long been considered to arise in middle age and, after their repeated proliferation, resulting in further damage to the genome, they progress to more aggressive and lethal cancers. However, in 2014, some studies were reported that might lead to a marked change in our understanding of the natural history of thyroid cancer. A high prevalence of papillary carcinoma in the young suggested that the first initiation of thyroid cancer is likely to occur in the infantile period. Read More

    Radioguided sentinel lymph node biopsy in patients with papillary thyroid carcinoma.
    Gland Surg 2016 Dec;5(6):591-602
    Department of Surgery, Morphology, and Experimental Medicine, S. Anna University Hospital, University of Ferrara, Ferrara, Italy.
    Background: The ATA guidelines do not recommend prophylactic central compartment neck dissection in patients with T1-T2 papillary thyroid carcinoma (PTC) with no clinical evidence of lymph node metastasis, however patients' staging is recommended. Lymph node metastasis may be present also in small PTC, but preoperative ultrasound identifies suspicious cervical lymphadenopathy in 20-30% of patients. The role of sentinel lymph node biopsy (SLNB) remain open to debate. Read More

    Evaluation of thyroid lesions by fine-needle aspiration cytology based on Bethesda system for reporting thyroid cytopathology classification among the population of South Bihar.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):265-270
    Department of Pathology, Patna Medical College and Hospital, Patna, Bihar, India.
    Background: Fine-needle aspiration (FNA) of the thyroid gland has proven to be an important and widely accepted, cost-effective, simple, safe, and accurate method triaging patients with thyroid nodules. Awareness and understanding of wide spectrum thyroid disorders are of great value because most lesions are treatable by medical or surgical management.

    Aim: The aim of this study is to determine the accuracy of FNA cytology (FNAC) in the diagnosis of thyroid lesion using the Bethesda system for reporting thyroid cytopathology nomenclature (BSRTC) and to correlate these with histopathological findings. Read More

    Synergistic activity of N-hydroxy-7-(2-naphthylthio) heptanomide and sorafenib against cancer stem cells, anaplastic thyroid cancer.
    Neoplasia 2017 Jan 27;19(3):145-153. Epub 2017 Jan 27.
    Thyroid Cancer Center, Gangnam Severance Hospital, Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Gangnam Severance Hospital, Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea. Electronic address:
    Anaplastic thyroid carcinoma (ATC) although rare is the most deadly form of thyroid cancer. The fatality rate for ATC is high-pitched, the survival rate at 1 year after diagnosis is <20%. Control of ATC is severely hard and widespread with unpredictability. Read More

    A variation in recurrence patterns of papillary thyroid cancer with disease progression: A long-term follow-up study.
    Head Neck 2017 Jan 31. Epub 2017 Jan 31.
    Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea.
    Background: Studies effectively examining temporal patterns of papillary thyroid cancer (PTC) recurrence are currently lacking. The purpose of this study was to examine sites of PTC recurrence, interval from initial treatment to recurrence, and changing patterns of recurrence during long-term follow-up.

    Methods: Records of 134 patients with PTC recurrence were analyzed retrospectively. Read More

    Outcome of large noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
    Thyroid 2017 Jan 30. Epub 2017 Jan 30.
    Memorial Sloan-Kettering Cancer Center, Pathology , 1275 York Avenue , New York, New York, United States , 10021 ;
    Background: In 2016, encapsulated papillary thyroid carcinoma, follicular variant without invasion was renamed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, many endocrinologists remain uneasy about managing large (≥ 4 cm) NIFTP conservatively without radioactive iodine (RAI) therapy. The objectives of this study are to characterize the clinicopathologic characteristics and outcome of large NIFTP in order to assist therapeutic decision making. Read More

    [A Case of Mediastinal Dissection by Video-Assisted Thoracoscopic Surgery (VATS)in a Patient with Mediastinal Nodal Recurrence from Thyroid Carcinoma after Primary Surgery via Median Sternotomy].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2130-2132
    Dept. of Surgery, Okayama Rosai Hospital.
    A70 's male was diagnosed with advanced papillary thyroid carcinoma and underwent total thyroidectomy with left lymph node dissection(T4a, N1b, M0, stage IV A). Six years after the surgery, subclavicular and mediastinal lymph node recurrence was observed. Radioiodine therapy was not successful for those lesions. Read More

    [A Case of Minimal Thyroid Carcinoma Diagnosed by a Solitary Pulmonary Metastasis].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2127-2129
    Dept. of Surgery, Okayama Rosai Hospital.
    We report a case of minimal thyroid carcinoma diagnosed by a solitary pulmonary metastasis. A 70's man visited a medical practitioner because of chest discomfort, and there was an abnormality on the chest X-ray. Chest computed tomography(CT) showed a nodule in the right middle lobe of the lung. Read More

    [Effectiveness of Lenvatinib for Thyroid Cancer with Lung Metastases - Report of a Case].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2121-2123
    Dept. of Breast Surgery, Akiru Municipale Medical Center.
    A 73-year-old woman visited our hospital 1 year 4 months ago because of multiple lung masses that were incidentally detected on CT. We subsequently conducted a whole body examination. Ultrasonography revealed multiple masses in her thyroid. Read More

    [Clinico-pathological features of papillary thyroid cancer coexistent with Hashimoto's thyroiditis].
    Orv Hetil 2017 Feb;158(5):178-182
    Patológiai Intézet, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.
    Introduction And Aim: Former studies suggest the frequent coexistence of Hashimoto's thyreoditis with papillary thyroid cancer, frequently featured by multifocal carcinogenesis but lower clinical stages compared to thyroid cancers lacking thyroiditis. We examined the clinico-pathological correlations between Hashimoto's thyroditis and papillary thyroid cancer in our region in the North-Eastern part of Hungary.

    Patients And Method: We included a total of 230 patients with papillary thyroid cancer who underwent thyroid surgery at the Surgical Department of the University of Debrecen. Read More

    False-positive cytopathology results for papillary thyroid carcinoma: A trap for thyroid surgeons.
    Clin Otolaryngol 2017 Jan 28. Epub 2017 Jan 28.
    Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
    Objectives: Current preoperative diagnosis of thyroid nodules remains imperfect despite recent advances in cytopathology and molecular diagnostics. False-positivity in preoperative fine needle aspiration cytology (FNAC) may lead to overtreatment of patients, including total thyroidectomy, and sometimes to lawsuits for misdiagnosis and malpractice. In this study, we analyzed clinical characteristics and pathologic findings in patients with false-positivity for papillary thyroid carcinoma (PTC) in FNAC. Read More

    Is Male Gender a Prognostic Factor for Papillary Thyroid Microcarcinoma?
    Ann Surg Oncol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background: Male gender is a prognostic factor of poor outcome in papillary thyroid carcinoma (PTC). We investigated the prognostic role of male gender in papillary thyroid microcarcinoma (PTMC).

    Methods: We included 2930 patients who underwent surgery at Asan Medical Center for PTC. Read More

    Improved Diagnostic Accuracy Using Arterial Phase CT for Lateral Cervical Lymph Node Metastasis from Papillary Thyroid Cancer.
    AJNR Am J Neuroradiol 2017 Jan 26. Epub 2017 Jan 26.
    From the Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    Background And Purpose: Contrast-enhanced CT protocols for papillary thyroid cancer are yet to be optimized. Our aim was to compare the diagnostic accuracy of arterial phase CT and delayed-phase CT protocols for lateral cervical lymph node metastasis from papillary thyroid carcinoma by using the lymph node tissue attenuation.

    Materials And Methods: This retrospective study included 327 lateral cervical lymph nodes (177 metastatic and 150 benign) from 131 patients with papillary thyroid carcinoma (107 initially diagnosed and 24 recurrences). Read More

    Applying criteria of active surveillance to low-risk thyroid papillary cancer over a decade: How many surgeries and complications can be avoided?
    Thyroid 2017 Jan 26. Epub 2017 Jan 26.
    Duke, Radiology , Box 3808 , Durham, North Carolina, United States , 27710 ;
    Background: The 2015 American Thyroid Association guidelines acknowledged that "an active surveillance management approach can be considered as an alternative to immediate surgery" in patients with low risk papillary thyroid carcinoma (PTC). The aim of this study is to determine the proportion of PTC that would meet criteria for active surveillance and the surgeries and complications that could have been avoided.

    Methods: We retrospectively reviewed 681 patients with thyroid cancer who underwent thyroid surgery from 2003 to 2012. Read More

    Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure.
    Am J Surg Pathol 2017 Jan 25. Epub 2017 Jan 25.
    *Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA †Department of Pathology and Laboratory Medicine, New York University Langone Medical Center, New York, NY.
    The ETV6-NTRK3 translocation characterizes a subset of radiation associated and pediatric papillary thyroid carcinomas (PTCs). We now describe the clinicopathologic features of ETV6-NTRK3 translocated PTC in an adult population without radiation exposure. Twelve cases were identified by next-generation sequencing (ThyroSeq version 2). Read More

    The effects of radioactive iodine therapy on olfactory function.
    Am J Rhinol Allergy 2016 Nov;30(6):206-210
    Otorhinolaryngology Department, Istanbul Training and Research Hospital, Istanbul, Turkey.
    Purpose: To determine the possible adverse effects of radioactive iodine (RAI) treatment on the olfactory functions of patients with differentiated thyroid carcinoma.

    Materials And Methods: This prospective clinical study included 63 Turkish patients who had been diagnosed with papillary thyroid carcinoma only to ensure homogeneity. The Connecticut Chemosensory Clinical Research Center olfactory test was administered at 1 week before treatment and at the third week and the first year after treatment. Read More

    Upregulation of the ESR1 Gene and ESR Ratio (ESR1/ESR2) is Associated with a Worse Prognosis in Papillary Thyroid Carcinoma: The Impact of the Estrogen Receptor α/β Expression on Clinical Outcomes in Papillary Thyroid Carcinoma Patients.
    Ann Surg Oncol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea.
    Background: A gender disparity exists with respect to the incidence of papillary thyroid cancer (PTC), suggesting that sex hormones such as estrogen play a role in PTC development and progression. In this study, we compared estrogen receptor gene expression patterns in PTCs to determine the clinical significance of estrogen gene expression in PTC.

    Methods: We analyzed ESR1 and ESR2 messenger RNA expression counts using data from The Cancer Genome Atlas (TCGA). Read More

    MicroRNA-363-3p inhibits papillary thyroid carcinoma progression by targeting PIK3CA.
    Am J Cancer Res 2017 1;7(1):148-158. Epub 2017 Jan 1.
    Department of Anesthesia, The First Hospital of Jilin University 71# Xinmin Street, Chaoyang District, Changchun 130021, Jilin, P. R. China.
    MicroRNA-363-3p (miR-363-3p) reportedly plays crucial roles in tumor development and progression in many types of cancers. However, its role in papillary thyroid carcinoma (PTC) remain largely unclear. We therefore investigated the function and underlying mechanism of miR-363-3p in PTC. Read More

    RASSF1A promoter methylation is associated with increased risk of thyroid cancer: a meta-analysis.
    Onco Targets Ther 2017 9;10:247-257. Epub 2017 Jan 9.
    Department of Cardiovascular Diseases.
    Objective: Previous studies have reported that Ras-associated domain family 1A (RASSF1A), the most commonly silenced tumor suppressor via promoter methylation, played vital roles in the development of carcinogenesis. The purpose of this meta-analysis was to determine whether RASSF1A promoter methylation increased the risk of thyroid cancer.

    Methods: PubMed, Embase, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure databases were searched to obtain eligible studies. Read More

    The ATA Guidelines on Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of eFVPTC without Invasion to NIFTP.
    Thyroid 2017 Jan 23. Epub 2017 Jan 23.
    The University of Texas M. D. Anderson Cancer Center, Pathology , 1515 Holcombe Blvd, Unit 085 , Houston, Texas, United States , 77030 ;
    American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on and make recommendations related to the suggested new classification of Encapsulated Follicular Variant Papillary Thyroid Carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with the recusal of three members who were authors on the paper under review. Four pathologists and one endocrinologist were added for this specific review. Read More

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