21,400 results match your criteria Thyroid Papillary Carcinoma


FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway.

Mol Cell Endocrinol 2020 Jun 30:110925. Epub 2020 Jun 30.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. Electronic address:

Forkhead box N3 (FOXN3) is a subtype of FOX family that has been demonstrated to be implicated in several cancers. However, the role of FOXN3 in papillary thyroid carcinoma (PTC) and its mechanisms have not yet been investigated. Our results showed that FOXN3 was markedly down regulated in PTC tissues and cell lines. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110925DOI Listing

Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment.

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):443-455. Epub 2020 Jun 24.

Laboratory of Pathology CSD Health Care, Kyiv, Ukraine.

Background: The relationship between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains uncertain. We assessed the impact of HT on the tumor immune microenvironment (TIME) in PTC.

Methods: Thirty patients with PTC (group 1) and 30 patients with PTC and HT (group 2) were enrolled in this pilot study. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.443DOI Listing

Development and Validation of a Risk Scoring System Derived from Meta-Analyses of Papillary Thyroid Cancer.

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):435-442. Epub 2020 Jun 24.

Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Background: The aim of this study was to develop a scoring system to stratify the risk of papillary thyroid cancer (PTC) and to select the proper management.

Methods: We performed a systematic search of MEDLINE and Embase. Data regarding patients' prognoses were obtained from the included studies. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.435DOI Listing

Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer.

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):396-406. Epub 2020 Jun 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul, Korea.

Background: Obesity is associated with thyroid cancer risk. Adiponectin has insulin-sensitizing and anti-inflammatory effects, while progranulin is associated with inflammation and tumorigenesis. We investigated serum adiponectin and progranulin levels in patients with benign thyroid nodule (benign group) and papillary thyroid cancer (PTC; PTC group). Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.396DOI Listing

Association of Serum Progranulin Levels with Progression of Papillary Thyroid Cancer.

Authors:
Won Gu Kim

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):288-289. Epub 2020 Jun 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3803/EnM.2020.35.2.288DOI Listing

Case Report: Familial Hypocalciuric Hypercalcaemia and Hashimoto's Thyroiditis.

Front Surg 2020 16;7:30. Epub 2020 Jun 16.

Department of Transplant and Endocrine Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

Hypercalcaemia can be caused by many disorders. Primary hyperparathyroidism is the leading cause with parathyroidectomy being the definitive management. Familial hypocalciuric hypercalcaemia is a rarer cause in which resection of the parathyroid tissue does not result in normalized serum calcium. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308482PMC

Plasma Metabolic Profiling of Human Thyroid Nodules by Gas Chromatography-Mass Spectrometry (GC-MS)-Based Untargeted Metabolomics.

Front Cell Dev Biol 2020 16;8:385. Epub 2020 Jun 16.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

One of the challenges in the area of diagnostics of human thyroid cancer is a preoperative diagnosis of thyroid nodules with indeterminate cytology. Herein, we report an untargeted metabolomics analysis to identify circulating thyroid nodule metabolic signatures, to find new novel metabolic biomarkers. Untargeted gas chromatography-quadrupole-mass spectrometry was used to ascertain the specific plasma metabolic changes of thyroid nodule patients, which consisted of papillary thyroid carcinoma (PTC; = 19), and multinodular goiter (MNG; = 16), as compared to healthy subjects ( = 20). Read More

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http://dx.doi.org/10.3389/fcell.2020.00385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308550PMC

Urinary Exosomal Thyroglobulin in Thyroid Cancer Patients With Post-ablative Therapy: A New Biomarker in Thyroid Cancer.

Front Endocrinol (Lausanne) 2020 16;11:382. Epub 2020 Jun 16.

Department of Internal Medicine, National Taiwan University Hospital Yun-Lin/Hsin-Chu Branch, College of Medicine, National Taiwan University, Taipei, Taiwan.

Most patients with thyroid cancer typically receive thyroidectomy with ablative radioactive iodine therapy. Such patients were followed with thyroid ultrasonography and serial serum thyroglobulin evaluation. Exosomes are nanovesicles secreted into extracellular environments, including plasma, saliva, urine, and other body fluids of patients with cancer. Read More

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http://dx.doi.org/10.3389/fendo.2020.00382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308545PMC

Differences in Gene Expression Profile of Primary Tumors in Metastatic and Non-Metastatic Papillary Thyroid Carcinoma-Do They Exist?

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Nuclear Medicine and Endocrine Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, 44-101 Gliwice, Poland.

Molecular mechanisms of distant metastases (M1) in papillary thyroid cancer (PTC) are poorly understood. We attempted to analyze the gene expression profile in PTC primary tumors to seek the genes associated with M1 status and characterize their molecular function. One hundred and twenty-three patients, including 36 M1 cases, were subjected to transcriptome oligonucleotide microarray analyses: (set A-U133, set B-HG 1. Read More

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http://dx.doi.org/10.3390/ijms21134629DOI Listing

Warthin-like and classic papillary thyroid cancer have similar clinical presentation and prognosis.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Objective: Warthin-like papillary thyroid cancer (WL-PTC) is an uncommon variant of PTC, usually associated with lymphocytic thyroiditis. Scarce evidence suggests that WL-PTC has similar clinical presentation to classic PTC (C-PTC), with no studies comparing risks of recurrence and response to treatment between both variants. Our objective was to describe the clinical presentation and prognosis of WL-PTC and compare it to C-PTC. Read More

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http://dx.doi.org/10.20945/2359-3997000000270DOI Listing

Risk factors of skip lateral lymph node metastasis in papillary thyroid carcinoma.

Eur Arch Otorhinolaryngol 2020 Jun 30. Epub 2020 Jun 30.

Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Purpose: Cervical lymph node metastasis is a prognostic factor of papillary thyroid carcinoma (PTC). This study aimed to investigate clinicopathological features and risk factors of skip lateral lymph node metastasis in PTC patients.

Methods: We retrospectively reviewed medical records of patients who underwent simultaneous total thyroidectomy with therapeutic central compartment lymph node dissection (LND) and lateral LND for primary PTC from 2014 to 2019. Read More

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http://dx.doi.org/10.1007/s00405-020-06176-4DOI Listing

Clinicopathological characterization and prognostic implication of FOXP3 and CK19 expression in papillary thyroid carcinoma and concomitant Hashimoto's thyroiditis.

Sci Rep 2020 Jun 30;10(1):10651. Epub 2020 Jun 30.

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Papillary thyroid carcinoma (PTC) is considered the most prevalent thyroid malignancy. The association between Hashimoto's thyroiditis (HT) and PTC is still unclear. We aimed to examine the clinicopathological impact of immunohistochemical staining of FOXP3 and Cytokeratin 19 in PTC and concomitant HT and their correlation with patients' outcome and survival. Read More

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http://dx.doi.org/10.1038/s41598-020-67615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326975PMC

Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Endocrinology, Diabetes, and Metabolism, Mayo Clinic Florida, Jacksonville, Florida, USA.

BCL6 corepressor like-1 (BCORL1) mutation has rarely been described in thyroid cancer or in association with BRAF mutations in any malignancy. However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the BRAF K601E and BCORL1 mutations. The patient underwent a total thyroidectomy for a 3. Read More

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http://dx.doi.org/10.1136/bcr-2019-234208DOI Listing

Standards and Definitions in Neck Dissections of Differentiated Thyroid Cancer.

Sisli Etfal Hastan Tip Bul 2018 1;52(3):149-163. Epub 2018 Oct 1.

Department of General Surgery, Bahcesehir University Faculty of Medicine, Istanbul, Turkey.

Papillary and follicular thyroid carcinomas arising from the follicular epithelial cells and forming differentiated thyroid cancer (DTC) consist of >95% of thyroid cancers. Lymph node metastasis to the neck is common in DTC, especially in papillary thyroid cancer. The removal of only the metastatic lymph nodes (berry picking) does not help to achieve a potential positive contribution to the survival and recurrence of lymph node dissection in the DTC. Read More

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http://dx.doi.org/10.14744/SEMB.2018.14227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315088PMC
October 2018

Is only Thyroid Peroxidase Antibody Sufficient for Diagnosing Chronic Lymphocytic Thyroiditis?

Sisli Etfal Hastan Tip Bul 2018 8;52(2):97-102. Epub 2018 Jun 8.

Department of Endocrinology and Metabolism, Health Sciences University Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: Recently, only anti-thyroid peroxidase (anti-TPO) has been suggested as an autoantibody in the diagnosis of chronic lymphocytic thyroiditis (CLT). In contrast, anti-thyroglobulin (anti-Tg) positivity has also been reported to be important. To evaluate this relationship more clearly, we planned to retrospectively investigate the autoantibody levels of the patients who underwent thyroid surgery for various reasons and those with CLT in postoperative pathology. Read More

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http://dx.doi.org/10.14744/SEMB.2017.36450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315066PMC

Randomised comparison of 1.1 GBq and 3.7 GBq radioiodine to ablate the thyroid in the treatment of low-risk thyroid cancer: a 13-year follow-up.

Acta Oncol 2020 Jun 30:1-8. Epub 2020 Jun 30.

Department of Radiation Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland.

The optimal activity of radioiodine (I-131) administered for ablation therapy in papillary and follicular thyroid cancer after thyroidectomy remains unknown in a long-term (> 10 year) follow-up. Some, shorter follow-up studies suggest that activities 1.1 GBq and 3. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1785003DOI Listing

Genetic relationship between Hashimoto`s thyroiditis and papillary thyroid carcinoma with coexisting Hashimoto`s thyroiditis.

PLoS One 2020 30;15(6):e0234566. Epub 2020 Jun 30.

Center of Excellence in Genomic Medicine Research, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Hashimoto's thyroiditis (HT) is present in the background of around 30% of papillary thyroid carcinomas (PTCs). The genetic predisposition effect of this autoimmune condition is not thoroughly understood. We analyzed the microarray expression profiles of 13 HT, eight PTCs with (w/) coexisting HT, six PTCs without (w/o) coexisting HT, six micro PTCs (mPTCs), and three normal thyroid (TN) samples. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234566PLOS

Long noncoding RNAs SET-binding factor 2-antisense RNA1 promotes cell growth through targeting miR-431-5p/CDK14 axis in human papillary thyroid cancer.

Kaohsiung J Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

Papillary thyroid cancer (PTC) is a frequent thyroid malignancy. With the significant regulatory role in tumor progression, more attention has been employed to investigate mechanism of long noncoding RNAs (lncRNAs) in progression of PTC. We prospectively explored the mechanism whereby lncRNA SET-binding factor 2-antisense RNA1 (SBF2-AS1) is implicated in pathogenesis of PTC. Read More

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http://dx.doi.org/10.1002/kjm2.12259DOI Listing

Nomogram for Predicting Central Lymph Node Metastasis in Papillary Thyroid Cancer: A Retrospective Cohort Study of Two Clinical Centers.

Cancer Res Treat 2020 Jun 9. Epub 2020 Jun 9.

Department of General Surgery, Shanghai Jiaotong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China.

Purpose: Central lymph node metastasis (CNM) are highly prevalent but hard to detect preoperatively in papillary thyroid carcinoma (PTC) patients, while the significance of prophylactic compartment central lymph node dissection (CLND) remains controversial as a treatment option. We aim to establish a nomogram assessing risks of CNM in PTC patients, and explore whether prophylactic CLND should be recommended.

Materials And Methods: One thousand four hundred thirty-eight patients from two clinical centers that underwent thyroidectomy with CLND for PTC within the period 2016-2019 were retrospectively analyzed. Read More

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http://dx.doi.org/10.4143/crt.2020.254DOI Listing

[Molecular markers as risk factors for thyroid cancer].

Ter Arkh 2019 Oct 15;91(10):119-123. Epub 2019 Oct 15.

Sechenov First Moscow State Medical University (Sechenov University).

Thyroid cancer is the most common malignant tumor of the endocrine system. An increase in the incidence of thyroid cancer has been noted over the past decade, mainly due to papillary cancer. The influence of environmental factors, increased availability of medical care, including sensitive diagnostic tests, such as ultrasound and fine - needle aspiration (FNA), can affect the fact of the growth of this incidence. Read More

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http://dx.doi.org/10.26442/00403660.2019.10.000357DOI Listing
October 2019

Incidental detection of unexpected neck lymphatic III level node metastasis from occult papillary thyroid carcinoma during cervical disc surgery: first literature report.

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Pathology Department, District Hospital, Arkonska 4, 71-455 Szczecin, Poland.

Background: The regional lymph node metastases of papillary thyroid carcinoma are very common. Subclinical neck lymphatic malignancy of the undiagnosed papillary carcinoma can be found by chance at autopsy or intravitally, especially during neck imaging scrutiny for other reasons. And cervical lymph node metastasis as the initial manifestation of occult papillary thyroid carcinoma is very rare phenomenon. Read More

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http://dx.doi.org/10.5603/EP.a2020.0031DOI Listing

IGFBP3 as an indicator of lymph node metastasis and unfavorable prognosis for papillary thyroid carcinoma.

Clin Exp Med 2020 Jun 28. Epub 2020 Jun 28.

Affiliated Hospital of Guiyang Medical University, Guiyang, China.

Lymph node metastasis (LNM) is a usual event in papillary thyroid carcinoma (PTC) patients, which usually leads to poor prognosis. However, the molecular mechanisms of LNM remain unclear. Thus, we aimed to screen the possible key genes in the progression of LNM in PTC patients and further validate their roles. Read More

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http://dx.doi.org/10.1007/s10238-020-00642-3DOI Listing

Using Diffusion-Weighted MRI to Predict Central Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Feasibility Study.

Front Endocrinol (Lausanne) 2020 12;11:326. Epub 2020 Jun 12.

GE Healthcare, MR Research China, Bejing, China.

To investigate whether diffusion-weighted imaging (DWI) with multi b values can be used as a quantitative assessment tool to predict central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A total of 214 PTC patients were enrolled from January 2015 to April 2018. Each patient underwent multi b value DWI (300, 500, and 800 s/mm) preoperatively and then clinical treatment of central LN dissection at the Thyroid Surgery Department. Read More

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http://dx.doi.org/10.3389/fendo.2020.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303282PMC

Prevalence and diagnostic significance of noninvasive follicular thyroid neoplasm with papillary-like nuclear features among tumors previously diagnosed as follicular adenoma: a single-institutional study in Japan.

Endocr J 2020 Jun 26. Epub 2020 Jun 26.

Department of Surgery, Kuma Hospital, 8-2-35 Shimoyamate-dori, Chuo-ku, Kobe, Hyogo 650-0011, Japan.

The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate the incidence of NIFTP in tumors diagnosed as follicular adenoma (FA) in a Japanese institution and discuss the significance of NIFTP. In this study, 44 tumors were investigated, which were histologically diagnosed as FA at the Kuma Hospital in 2008. Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0198DOI Listing

Down-Regulation of the Mammalian Target of Rapamycin (mTOR) Pathway Mediates the Effects of the Paeonol-Platinum(II) Complex in Human Thyroid Carcinoma Cells and Mouse SW1736 Tumor Xenografts.

Med Sci Monit 2020 Jun 28;26:e922561. Epub 2020 Jun 28.

Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).

BACKGROUND This study aimed to investigate the effects of the paeonol-platinum(II) (PL-Pt[II]) complex on SW1736 human anaplastic thyroid carcinoma cell line and the BHP7-13 human thyroid papillary carcinoma cell line in vitro and on mouse SW1736 tumor xenografts in vivo. MATERIAL AND METHODS The cytotoxic effects of the PL-Pt(II) complex on SW1736 cells and BHP7-13 cells was measured using the MTT assay. Western blot measured the expression levels of cyclins, cell apoptotic proteins, and signaling proteins. Read More

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http://dx.doi.org/10.12659/MSM.922561DOI Listing

Is it possible to intraoperatively modulate the extent of thyroidectomy in small papillary thyroid carcinoma?

Surgery 2020 Jun 24. Epub 2020 Jun 24.

UOC Chirurgia Endocrina e Metabolica-Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento Universitario di Medicina e Chirurgia Traslazionale-Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Thyroid lobectomy is the preferred option for small, unifocal papillary thyroid carcinoma. Involvement of the central neck lymph nodes is an indication for total thyroidectomy plus central neck dissection. We aimed to verify if frozen section examination of ipsilateral central neck nodes can identify the subgroup of patients scheduled for thyroid lobectomy intraoperatively who could benefit of more extensive initial operative treatment. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.043DOI Listing

BRAF mutation, BRAF-activated long non-coding RNA and miR-9 expression in papillary thyroid carcinoma, and their association with clinicopathological features.

World J Surg Oncol 2020 Jun 27;18(1):145. Epub 2020 Jun 27.

The Fourth Department of General Surgery, the Second Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Harbin, 150001, Heilongjiang Province, China.

Background: The incidence of thyroid cancer is increasing worldwide. This study investigated the association of B-type RAF kinase (BRAF) mutation status, the expression of BRAF-activated long non-coding RNA (BANCR) and microRNA miR-9, and the clinicopathological features of papillary thyroid carcinoma (PTC).

Methods: Clinicopathological data for PTC patients (n = 51) diagnosed and treated between 2018 and 2019 were collected. Read More

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http://dx.doi.org/10.1186/s12957-020-01923-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321545PMC

[Limitation of possibilities of cytological diagnosis of papillary thyroid cancer at the pre-surgery stage].

Arkh Patol 2020 ;82(3):24-30

National Medical Research Center of Endocrinology, Moscow, Russia.

Aim Of Study: A comparison of papillary cancer variants diagnosed on the basis of cytological findings of pre-surgery puncture biopsies with a histological variant of papillary cancer.

Materials And Methods: The findings of two experts specializing in cytological diagnostics of thyroid nodules that diagnosed a possible variant of papillary cancer were compared with histological findings based on the study of material from surgically removed neoplasms.

Results: It was shown that the cytological examination at the pre-surgery stage has significant limitations in diagnosing the histological variant of the tumor, despite high sensitivity of method in diagnosing papillary cancer in general. Read More

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http://dx.doi.org/10.17116/patol20208203124DOI Listing
January 2020

HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line.

Pathol Oncol Res 2020 Jun 26. Epub 2020 Jun 26.

Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.

While papillary thyroid cancer (PTC) has largely favorable prognosis, anaplastic thyroid cancer (ATC) is a rare but extremely aggressive malignancy with grim clinical outcome. Even though new therapeutic options are emerging for ATC, additional preclinical models and novel combinations are needed for specific subsets of patients. We established a novel cell line (PF49) from the malignant pleural effusion of a 68-year-old male patient with ATC that rapidly transformed from a BRAF and TERT promoter mutant PTC. Read More

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http://dx.doi.org/10.1007/s12253-020-00834-yDOI Listing

The correlation between ultrasonographic features, bFGF, and the local invasiveness of thyroid papillary carcinoma.

Medicine (Baltimore) 2020 Jun;99(26):e20644

Department of Ultrasound.

The present study aimed to investigate the correlation between ultrasonographic features, basic fibroblast growth factor (bFGF), and the local invasiveness of papillary thyroid carcinoma (PTC).A total of 350 samples of thyroid nodules were collected. Routine ultrasonography was performed before the operation and routine pathological diagnosis and bFGF detection were performed after the operation. Read More

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http://dx.doi.org/10.1097/MD.0000000000020644DOI Listing

Tyrosine kinase inhibitor therapy and metabolic re-modeling in papillary thyroid cancer.

Endocr Relat Cancer 2020 Jun 1. Epub 2020 Jun 1.

T McMullen, Oncology, University of Alberta, Edmonton, Canada.

The present study used [18F]FDG-PET to study glucose metabolism and tumor responses for thyroid cancer xenografts expressing the glycolytic pathway modulators platelet-derived growth factor receptor (PDGFR) and BRAFV600E. PET data were correlated with immunohistochemistry staining and kinetic analysis for facilitative glucose transporter 1 (GLUT1) and hexokinase-II (HK2). Vemurafenib decreased [18F]FDG uptake in BCPAP cells in vitro; however, it was increased by ~70% with imatinib application to BCPAP cells. Read More

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http://dx.doi.org/10.1530/ERC-20-0135DOI Listing

The Fractal and GLCM Textural Parameters of Chromatin May Be Potential Biomarkers of Papillary Thyroid Carcinoma in Hashimoto's Thyroiditis Specimens.

Microsc Microanal 2020 Jun 25:1-14. Epub 2020 Jun 25.

Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080Zemun-Belgrade, Serbia.

Occasionally, Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) share similar nuclear features. The current study aims to quantify the differences between the investigated specimens of HT-associated PTC versus the HT alone, to reduce the subjective experience of an observer, by the use of fractal parameters as well as gray-level co-occurrence matrix (GLCM) textural parameters. We have analyzed 250 segmented nuclei per group (nn = 25 per patient and np = 10 patients per group) using the ImageJ software (NIH, Bethesda, MD, USA) as well as an in-house written code for the GLCM analysis. Read More

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http://dx.doi.org/10.1017/S1431927620001683DOI Listing

Prophylactic lymph node dissection in clinically N0 differentiated thyroid carcinoma: example of personalized treatment.

Per Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pharmacology - Clinical Pharmacology Unit, National & Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor, 75 Mikras Asias, 11527-Goudi, Athens, Greece.

Considering the 'differentiated thyroid carcinoma (DTC) epidemic', the indolent nature of DTC imposes a treatment paradigm shift toward elimination of recurrence. Lymph node metastases in cervical compartments, encountered in 20-90% of DTC, are the main culprit of recurrent disease, affecting 5-30% of patients. Personalized risk-stratified cervical prophylactic lymph node dissection (PLND) at initial thyroidectomy in DTC with no clinical, sonographic or intraoperative evidence of lymph node metastases (clinically N0) has been advocated, though not unanimously. Read More

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http://dx.doi.org/10.2217/pme-2019-0119DOI Listing

Predictors of recurrence after total thyroidectomy plus neck dissection and radioactive iodine ablation for high-risk papillary thyroid carcinoma.

J Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Departments of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: American Thyroid Association (ATA) proposed management guidelines for differentiated thyroid cancer, including a three-tiered risk stratification system for structural recurrence. This study aimed to compare the various 2015 ATA criteria for the strength of association with the recurrence of high-risk papillary thyroid carcinoma (PTC).

Study Design: This study included 545 consecutive patients who underwent total thyroidectomy plus neck dissection and radioactive iodine ablation (RAI) for previously untreated high-risk PTC. Read More

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http://dx.doi.org/10.1002/jso.26090DOI Listing

Papillary thyroid carcinoma: an ultrasound-based nomogram improves the prediction of lymph node metastases in the central compartment.

Eur Radiol 2020 Jun 25. Epub 2020 Jun 25.

Medical College of Nankai University, No.94, Weijin Road, Nankai District, Tianjin, 300071, People's Republic of China.

Objectives: To develop a nomogram based on postoperative clinical and ultrasound findings to quantify the probability of central compartment lymph node metastases (CLNM).

Methods: A total of 952 patients with histologically confirmed papillary thyroid carcinoma (PTC) were included in this retrospective study and assigned to three groups based on sex and age. The strongest predictors for CLNM were selected according to ultrasound imaging features, and an ultrasound (US) signature was constructed. Read More

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http://dx.doi.org/10.1007/s00330-020-06906-6DOI Listing

Comparison of Ultrasonography Features and K-TIRADS for Isthmic and Lobar Papillary Thyroid Carcinomas: A Single-Center Study.

Front Endocrinol (Lausanne) 2020 4;11:328. Epub 2020 Jun 4.

Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, South Korea.

This study aimed to compare ultrasonography (US) features and the Korean-Thyroid Imaging Reporting and Data System (K-TIRADS) categories for diagnosing isthmic and lobar papillary thyroid carcinomas (PTC). From January 2009 to December 2012, 163 patients who underwent thyroid surgery and were confirmed with a post-operative histopathological diagnosis of isthmic PTC were retrospectively included. Fifty-nine patients were excluded because their tumor size was <0. Read More

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http://dx.doi.org/10.3389/fendo.2020.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287017PMC

THE ASSOCIATION BETWEEN TUMOR TISSUE CALCIFICATION, OBESITY, AND THYROID CANCER INVASIVENESS IN A COHORT STUDY.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, 126 Xiantai Street, Changchun 130013, Jilin Province, China.

. We examined the relationships between tumor tissue calcifications of papillary thyroid cancer (PTC), body mass index (BMI), and tumor invasiveness. . Read More

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http://dx.doi.org/10.4158/EP-2020-0057DOI Listing

UNILATERAL TNM T1 AND T2 THYROID PAPILLARY CARCINOMA WITH LATERAL CERVICAL LYMPH NODE METASTASIS: TOTAL THYROIDECTOMY OR LOBECTOMY?

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Department of Thyroid Surgery, The First Hospital of China Medical University, No.155, Nanjing Bei Street, Heping District Shenyang, Liaoning Province, 110001, China.

: The aim of this study was to explore the effect of total thyroidectomy (TT) and lobectomy (LT) on the prognosis of unilateral papillary thyroid carcinoma (PTC)with lateral cervical lymph node metastasis. : Patients with PTC and lateral cervical lymph node metastasis who underwent lateral cervical lymph node dissection between January 2007 and December 2016 were retrospectively reviewed. To investigate the effect of surgical procedure on the prognosis of lymph node metastasis patients, other high-risk factors such as extrathyroidal invasion and large tumor size were excluded. Read More

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http://dx.doi.org/10.4158/EP-2020-0125DOI Listing

[Differential protein expressions in papillary thyroid carcinoma patients with or without Hashimoto's thyroiditis].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):463-468

Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To explore the differential protein expressions in papillary thyroid carcinoma (PTC) with or without Hashimoto's thyroiditis (HT). Tissue microarray was prepared and the protein expression levels of v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), vascular endothelial growth factor (VEGF), cyclinD1, mesothelial cell (MC) , CD56 and Galectin3 in the PTC tissues with or without HT were detected by immunohistochemical staining. The positive expression rates of BRAF protein in the PTC tissues with or without HT groups were 55. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20191219-00824DOI Listing

[Clinical analysis of mediastinal lymph node dissection through sternotomy approach in the treatment of papillary thyroid carcinoma with mediastinal lymph node metastasis].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1866-1871

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the rule of mediastinal lymph node metastasis of papillary thyroid carcinoma and the application of therapeutic mediastinal lymph node dissection through the sternotomy approach in the treatment of mediastinal lymph node metastasis of papillary thyroid carcinoma. All cases of papillary thyroid carcinoma with mediastinal lymph node metastasis treated through sternotomy cooperated by thoracic surgeons and head and neck surgeons from January 2006 to January 2017 in Cancer Hospital of Chinese Academy of Medical Sciences were included in this study. The distribution, metastasis rate, metastasis degree, surgical method, surgical complications and postoperative survival of patients with mediastinal lymph node metastasis were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200428-01353DOI Listing

Correlation between F18-FDG PET/CT Imaging and BRAF V600E Genetic Mutation for the Early Assessment of Treatment Response in Papillary Thyroid Cancers.

J Pers Med 2020 Jun 19;10(2). Epub 2020 Jun 19.

Department of Endocrine Tumors and Nuclear Medicine, Institute of Oncology "Prof.dr.Ion Chiricuță" 400015 Cluj-Napoca, Romania.

In thyroid neoplastic pathology, the BRAF V600E mutation is shown to be involved in the oncogenesis of papillary thyroid cancer and its subtypes. The purpose of this study is to evaluate the correlation between the mutation of the BRAF V600E oncogene and the pathological standardized uptake values (SUV) at the F18-fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) evaluation, for a group of 20 patients with radically treated (total thyroidectomy and radioiodine therapy) papillary thyroid cancer, with subclinical persistent disease, at 6 months after the initial treatment. We analyzed the correlations between the values of SUV and the presence of the BRAF mutation as well with other prognostic factors such as stage, age, specific tumor markers (thyroglobulin and anti-thyroglobulin), extrathyroid extension, the presence of metastatic lymph nodes or distant metastasis. Read More

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http://dx.doi.org/10.3390/jpm10020052DOI Listing

Thyroid cancer neck lymph nodes metastasis: Meta-analysis of US and CT diagnosis.

Eur J Radiol 2020 Jun 13;129:109103. Epub 2020 Jun 13.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address:

Purpose: Ultrasound (US) is the first imaging technique in the assessment of cervical lymph nodes metastasis (LNM) of papillary thyroid cancer (PTC) patients preoperatively. Computed tomography (CT) exerts an influence on surgical strategy especially for patients with lateral cervical LNM. This meta-analysis aimed at assessing the diagnostic values of US and CT in detecting the cervical LNM in thyroid cancer patients. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109103DOI Listing

Prevalence and Risk of Metastatic Thyroid Cancers and Management Outcomes: A National Perspective.

Laryngoscope 2020 Jun 23. Epub 2020 Jun 23.

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, U.S.A.

Objectives: Examine the prevalence and risk of metastasis in thyroid cancers and management outcomes.

Study Design: Retrospective analysis of the National Cancer Database, 2004-2014.

Methods: The study population included adult (≥ 18 years) patients with thyroid cancer. Read More

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http://dx.doi.org/10.1002/lary.28722DOI Listing

A Randomized Comparison of Carbon Nanoparticles in Endoscopic Lymph Node Dissection Via the Bilateral Areola Approach for Papillary Thyroid Cancer.

Surg Laparosc Endosc Percutan Tech 2020 Apr 21. Epub 2020 Apr 21.

Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma.

Objective: We assess the value of carbon nanoparticles (CNP) staining in patients undergoing endoscopic thyroidectomy and central compartment lymph node (CLN) dissection via the bilateral areola approach [endoscopic thyroidectomy via bilateral areola approach (ETBAA)].

Methods: This was a prospective randomized study. Three hundred two consecutive early-stage thyroid cancer patients eligible for ETBAA were recruited at the Division of Thyroid Surgery, China-Japan Union Hospital, Jilin University, China. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000793DOI Listing

IL-34 is a potential biomarker for the treatment of papillary thyroid cancer.

J Clin Lab Anal 2020 Jun 23:e23335. Epub 2020 Jun 23.

Department of General Surgery, The First Hospital of China Medical University, Shenyang, China.

Background: Interleukin (IL)-34 is a recently discovered pro-inflammatory cytokine and is a vital regulator in different tumor types. However, the function of IL-34 in thyroid carcinoma has yet to be investigated. In this study, we analyzed the expression of IL-34 in human papillary thyroid cancer (PTC) samples and determined its effects on the proliferation and apoptosis of PTC cells. Read More

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http://dx.doi.org/10.1002/jcla.23335DOI Listing

Biologically-based modeling of radiation risk and biomarker prevalence for papillary thyroid cancer in Japanese a-bomb survivors 1958-2005.

Int J Radiat Biol 2020 Jul 2:1-12. Epub 2020 Jul 2.

Biostatistics Center, Kurume University, Kurume, Japan.

Thyroid cancer of papillary histology (PTC) is the dominant type in radio-epidemiological cohorts established after nuclear accidents or warfare. Studies on post-Chernobyl PTC and on thyroid cancer in the life span study (LSS) of Japanese a-bomb survivors consistently revealed high radiation risk after exposure during childhood and adolescence. For post-Chernobyl risk assessment overexpression of the CLIP2 gene was proposed as molecular biomarker to separate radiogenic from sporadic PTC. Read More

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http://dx.doi.org/10.1080/09553002.2020.1784488DOI Listing

Clinicopathologic factors and preoperative ultrasonographic characteristics for predicting central lymph node metastasis in papillary thyroid microcarcinoma: a single center retrospective study.

Braz J Otorhinolaryngol 2020 Jun 4. Epub 2020 Jun 4.

Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Department of Medical Imaging, Liaoning Province, People's Republic of China. Electronic address:

Introduction: The treatment of papillary thyroid microcarcinoma remains controversial. Central lymph node metastasis is common in papillary thyroid microcarcinoma and it is an important consideration in treatment strategy selection.

Objective: The aim of this study was to investigate clinicopathologic risk factors and thyroid nodule sonographic characteristics for central lymph node metastasis in papillary thyroid microcarcinoma. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.004DOI Listing

Papillary and Follicular Thyroid Cancer in children and adolescents: Current approach and future directions.

Authors:
Andrew J Bauer

Semin Pediatr Surg 2020 Jun 16;29(3):150920. Epub 2020 May 16.

The Thyroid Center, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA USA 19104; Department of Pediatrics, The Perelman School of Medicine, The University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA USA 19104. Electronic address:

An increasing number of children are diagnosed with differentiated thyroid cancer. With an excellent prognosis for the majority of pediatric patients, the goal of therapy is to optimize outcome while reducing complications. Increased knowledge of the somatic, oncogenic driver mutations provides opportunities to improve the accuracy of diagnosis, to stratify surgery, and to treat patients with morbidly invasive or refractory disease. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150920DOI Listing

Sarcoidosis with cryptococcal infection apparently engaging only immune-privileged body compartments: a case report.

BMC Infect Dis 2020 Jun 22;20(1):440. Epub 2020 Jun 22.

Medical Microbiology, Innlandet Hospital Trust, Lillehammer, Norway.

Background: Infection with the Cryptococcus neoformans yeast fungus is largely restricted to patients with HIV, sarcoidosis or immunosuppressive therapies. In sarcoidosis, there is intense local immune response in granuloma lesions, coupled with a paradoxical systemic anergy. An analysis of cryptococcal infection in sarcoidosis may therefore shed light on whether opportunistic pathogens preferentially engage immune-privileged tissues. Read More

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http://dx.doi.org/10.1186/s12879-020-05174-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310135PMC

CHEK2 Mutation in Patient with Multiple Endocrine Glands Tumors. Case Report.

Int J Environ Res Public Health 2020 Jun 18;17(12). Epub 2020 Jun 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Read More

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http://dx.doi.org/10.3390/ijerph17124397DOI Listing