19,488 results match your criteria Thyroid Papillary Carcinoma


Predictive factors for central lymph node and lateral cervical lymph node metastases in papillary thyroid carcinoma.

Clin Transl Oncol 2019 Mar 16. Epub 2019 Mar 16.

The Third Affiliated Hospital of Soochow University, Changzhou First People'S Hospital, Changzhou, Jiangsu, China.

Background: Central lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is common. But the association between primary tumor characteristics and specific features of metastatic lymph nodes in PTC has not been fully identified. Determining risk factors for LNM may help surgeons determine rational extent of lymph node dissection. Read More

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http://dx.doi.org/10.1007/s12094-019-02076-0DOI Listing

Risk factors for skip metastasis and lateral lymph node metastasis of papillary thyroid cancer.

Surgery 2019 Mar 12. Epub 2019 Mar 12.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Lymph node metastases from papillary thyroid cancer is believed to disseminate sequentially, first to the central neck and later to the lateral neck. Skip metastases of papillary thyroid cancer, however, are defined as lateral lymph node metastasis without central lymph node metastasis. The aim of this study was to investigate the risk factors for skip metastases and lateral lymph node metastasis of papillary thyroid cancer. Read More

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http://dx.doi.org/10.1016/j.surg.2019.01.025DOI Listing

The immunocytochemical expression of VE-1 (BRAF V600E-related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid-based cytology.

Cytopathology 2019 Mar 15. Epub 2019 Mar 15.

Division of Anatomic Pathology and Histology Catholic, University of Sacred Heart, Foundation "Agostino Gemelli" University Hospital, Largo Francesco Vito 1, 00168, Rome, Italy.

Background: The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in cytology and cell block samples is rarely performed, and its diagnostic value in cytology has not been well established. In this study, we sought to determine if VE1 is suitable for FNA and cell block method. Read More

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http://dx.doi.org/10.1111/cyt.12690DOI Listing

Association Between Radiomics Signature and Disease-Free Survival in Conventional Papillary Thyroid Carcinoma.

Sci Rep 2019 Mar 14;9(1):4501. Epub 2019 Mar 14.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Patients with papillary thyroid carcinoma (PTC) would benefit from risk stratification tools that can aid in planning personalized treatment and follow-up. The aim of this study was to develop a conventional ultrasound (US)-based radiomics signature to estimate disease-free survival (DFS) in patients with conventional PTC. Imaging features were extracted from the pretreatment US images of 768 patients with conventional PTC who were treated between January 2004 and February 2006. Read More

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http://dx.doi.org/10.1038/s41598-018-37748-4DOI Listing

Identification and analysis of genes associated with papillary thyroid carcinoma by bioinformatics methods.

Biosci Rep 2019 Mar 14. Epub 2019 Mar 14.

Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai, China.

The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. This study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from GEO database. Read More

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http://dx.doi.org/10.1042/BSR20190083DOI Listing

Exosomes increased angiogenesis in papillary thyroid cancer microenvironment.

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

Z Mo, Department of Endocrinology, Third Xiang-Ya Hospital, Central South University, Changsha, China.

Tumour-derived exosomes under hypoxic conditions contain informative microRNAs involved in the interaction of cancer and para-carcinoma cells, thus contributing to tissue remodelling of the tumour microenvironment (TME). Exosomes isolated from hypoxic papillary thyroid cancer cells, BCPAP cells and KTC-1 cells, enhanced the angiogenesis of human umbilical vein endothelial cells (HUVECs) compared with exosomes isolated from normal thyroid follicular cell line (Nthy-ori-3-1), normoxic BCPAP cells or KTC-1 cells both in vitro and vivo. miR-21-5p was significantly upregulated in exosomes from papillary thyroid cancer BCPAP cells under hypoxic conditions, while the exosomes isolated from hypoxic BCPAP cells with knock-down of miR-21-5p attenuated the promoting effect of angiogenesis. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-19-
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http://dx.doi.org/10.1530/ERC-19-0008DOI Listing
March 2019
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Combination treatment with BRAFV600E inhibitor, vemurafenib, and BH3 mimetic, navitoclax, for BRAF mutant thyroid carcinoma.

Thyroid 2019 Mar 14. Epub 2019 Mar 14.

School of Medicine, Kyungpook National University, Department of Nuclear Medicine, Daegu, Korea (the Republic of).

Background Vemurafenib is a selective BRAF inhibitor (BRAFi) that has shown promising activity in BRAFV600E-positive papillary thyroid cancer (PTC). However, adverse events and resistance to a single-agent BRAFi often require discontinuation of the targeted therapy in BRAFV600E-positive PTC. Thus, we investigated the expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) family members, which is frequently overexpressed in many human cancers to inhibit apoptosis, in PTC harboring the BRAFV600E mutation after BRAFi treatment and then evaluated the cytotoxic effects of a homology 3 domain (BH3)-mimetic in combination with a BRAFi. Read More

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http://dx.doi.org/10.1089/thy.2018.0511DOI Listing

Exosomal miRNA423-5p mediated oncogene activity in papillary thyroid carcinoma: a potential diagnostic and biological target for cancer therapy.

Authors:
W Ye X Deng Y Fan

Neoplasma 2019 Mar 7. Epub 2019 Mar 7.

Department of General Surgery, Center of Thyroid and Parathyroid, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Exosomes are considered important "messengers" between cells and their cargo, and some of the miRNAs composing their cargo may be involved in oncogenic activity. Exosomal miRNA423-5p (Ex-miRNA423-5p) is upregulated in gastric cancer and associated with its poor prognosis. However, the role of exosome-derived miRNAs in papillary thyroid cancer (PTC) is still unclear and needs further study. Read More

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http://dx.doi.org/10.4149/neo_2018_180824N643DOI Listing

Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.

Endocrine 2019 Mar 13. Epub 2019 Mar 13.

Division of Cytopathology, Department of Pathology, The Johns-Hopkins Hospital, Baltimore, USA.

Background: The nomenclature "Non-invasive Follicular Neoplasm with Papillary-like Nuclear Features (NIFTP)" was introduced in 2016. While NIFTP differs from classic papillary thyroid carcinoma (PTC) in imaging, cytomorphology, histology, molecular profile, treatment, follow up, outcome, and behavior, it largely overlaps with follicular variant of PTC at imaging and cytomorphology. Herein, we review the literature for better understanding NIFTP, and its impact on patient care. Read More

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http://dx.doi.org/10.1007/s12020-019-01887-zDOI Listing

Fortuitous discovery of non-fluorocholine-fixing papillary carcinoma of vesicular variant of the thyroid.

Eur Arch Otorhinolaryngol 2019 Mar 14. Epub 2019 Mar 14.

Centre hospitalo-universitaire de Nîmes, Service d'oto-rhino-laryngologie, Rue du Professeur Robert Debré, 30900, Nîmes, France.

Purpose: Characterization of thyroid nodules is crucial to propose surgical intervention for histological verification. Cervical ultrasound potentially combined with fine needle aspiration is recommended, and fluorocholine positron emission tomography (FCH-PET), commonly used in prostatic cancers, has been evaluated in the diagnosis of thyroid cancers in recent publications.

Methods: We present two cases of patients with multinodular thyroid and primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1007/s00405-019-05370-3DOI Listing

Serum miR-22 may be a biomarker for papillary thyroid cancer.

Oncol Lett 2019 Mar 4;17(3):3355-3361. Epub 2019 Feb 4.

Department of Otolaryngology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China.

The present study aimed to examine whether serum microRNA (miR)-22 may be considered a potential biomarker to differentiate patients with papillary thyroid cancer (PTC) from healthy controls. Reverse transcription-quantitative polymerase chain reaction demonstrated that serum miR-22 expression was significantly enhanced in patients with PTC compared with in patients with benign thyroid nodules (BTN) and healthy controls. The expression levels of miR-22 were also increased in the thyroid tissue of patients with PTC compared with in patients with BTN. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.10011
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http://dx.doi.org/10.3892/ol.2019.10011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396224PMC
March 2019
1 Read

TGF-β1 promotes the invasion and migration of papillary thyroid carcinoma cells by inhibiting the expression of lncRNA-NEF.

Oncol Lett 2019 Mar 18;17(3):3125-3132. Epub 2019 Jan 18.

Intensive Care Unit, Affiliated Xinhua Hospital of Dalian University, Dalian, Liaoning 116000, P.R. China.

Increased expression levels of transforming growth factor-β1 (TGF-β1) are associated with metastasis in papillary thyroid carcinoma (PTC), although the mechanisms involved remain unknown. The present study aimed to investigate these mechanisms. The results demonstrated that the expression levels of TGF-β1 mRNA were higher and those of lncRNA-NEF were lower in tumor tissues compared with in healthy tissues. Read More

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http://dx.doi.org/10.3892/ol.2019.9947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396259PMC
March 2019
1 Read

The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors.

Sci Rep 2019 Mar 13;9(1):4390. Epub 2019 Mar 13.

Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Laboratory for Endocrine Disruptors and Chair of Endocrinology University of Pavia, 27100, Pavia, Italy.

CXCL8 is a chemokine secreted by normal and thyroid cancer cells with proven tumor-promoting effects. The presence of BRAFV600E mutation is associated with a more aggressive clinical behavior and increased ability to secrete CXCL8 by papillary-thyroid-cancer cells. Aim of this study was to test the effect of the BRAF-inhibitor (PLX4720) on the basal and TNF-α-induced CXCL8 secretions in BRAFV600E mutated (BCPAP, 8305C, 8505C), in RET/PTC rearranged (TPC-1) thyroid-cancer-cell-lines and in normal-human-thyrocytes (NHT). Read More

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http://dx.doi.org/10.1038/s41598-019-40818-wDOI Listing

Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features.

Endocr J 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, Kuma Hospital, Kobe 856-8562, Japan.

We studied cytological specimens of conventional papillary thyroid carcinoma (PTC), follicular variant papillary thyroid carcinoma (FVPTC), and noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) (formerly noninvasive FVPTC) to identify useful cytological parameters for their differentiation. Cytological findings of invasive FVPTC and NIFTP were very similar to each other but differed from those of conventional PTC. Intranuclear cytoplasmic inclusions, true papillary cell clusters, monolayered cell sheets, ropy colloids, multinucleate giant cells, psammoma bodies, and cystic background were the observed characteristic features of conventional PTC. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0525DOI Listing

RISK OF MALIGNANCY IN THYROID CYTOLOGY: THE IMPACT OF THE RECLASSIFICATION OF NONINVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP).

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Endocrinology, Diabetes and Metabolism Department, University and Hospital Center of Coimbra, Coimbra, Portugal.

Objectives: Non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NEFVPTC) was recently reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). We aimed to compare the risk of malignancy (ROM) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) on fine-needle aspiration cytology (FNAC), before and after the reclassification, in a large cohort of patients.

Methods: We analyzed 5. Read More

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http://dx.doi.org/10.4158/EP-2018-0423DOI Listing

Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma.

Thyroid 2019 Mar 13. Epub 2019 Mar 13.

Asan Medical Center, Unitersity of Ulsan College of Medicine, Internal Medicine , 88, Olympic-ro 43-gil, Songpa-gu , Seoul, Korea, Republic of , 138-736 ;

Background Tumor volume (TV) of papillary thyroid carcinoma (PTC) increases exponentially during active surveillance and the growth rate differs for each patient. TV doubling time (TVDT) is considered as a strong dynamic marker for the prediction of growth rate and progression of the tumor. Methods In this cohort study, we analyzed 273 PTC patients who underwent active surveillance for over one year rather than immediate thyroid surgery. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0609
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http://dx.doi.org/10.1089/thy.2018.0609DOI Listing
March 2019
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Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy.

Arch Endocrinol Metab 2019 Feb;63(1):79-83

Grupo Brasileiro para Estudos de Lipodistrofias Herdadas e Adquiridas (BRAZLIPO), Hospital Universitário Walter Cantídio, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Read More

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http://dx.doi.org/10.20945/2359-3997000000096DOI Listing
February 2019
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Does the Bethesda category predict aggressive features in differentiated thyroid cancer?

Arch Endocrinol Metab 2019 Feb;63(1):12-15

Serviço de Endocrinologia do Hospital Universitário da Universidade Federal do Maranhão (UFMA), São Luís, MA, Brasil.

Objective: To analyze the importance of preoperative cytology of thyroid nodules and its relationship with mortality risk, recurrence risk, dynamic stratification, and aggressive characteristics (vascular invasion, aggressive histology, incomplete tumor resection, extrathyroidal extension of the tumor, and presence of lymph node and distant metastases).

Subjects And Methods: Retrospective evaluation of 153 patients diagnosed with differentiated thyroid carcinoma (DTC) and following up at the Hospital Universitário Presidente Dutra between January 1999 and December 2016.

Results: In all, 96% of the patients were female, 79. Read More

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http://dx.doi.org/10.20945/2359-3997000000098DOI Listing
February 2019

Impact of the updated TNM staging criteria on prediction of persistent disease in a differentiated thyroid carcinoma cohort.

Arch Endocrinol Metab 2019 Feb;63(1):5-11

Grupo de Tireoide, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, RS, Brasil.

Objective: The 8th TNM system edition (TNM-8) released in 2018 presents significant changes when compared to the 7th edition (TNM-7). The aim of this study was to assess the impact of changing the TNM staging criteria on the outcomes in a Brazilian cohort of differentiated thyroid carcinoma (DTC).

Subjects And Methods: DTC patients, attending a tertiary, University-based hospital, were classified by TNM-7 and TNM-8. Read More

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http://dx.doi.org/10.20945/2359-3997000000097DOI Listing
February 2019

Concomitant paraganglioma and thyroid carcinoma: A case report.

World J Clin Cases 2019 Mar;7(5):656-662

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.

Background: Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia (MEN). However, very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid carcinoma. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i5.656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406204PMC

BRAF mutation in cytologically indeterminate thyroid nodules: after reclassification of a variant thyroid carcinoma.

Onco Targets Ther 2019 21;12:1465-1473. Epub 2019 Feb 21.

Department of Otorhinolaryngology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand,

Purpose: Fine-needle aspiration biopsy (FNAB) is regarded by the Bethesda system as the gold-standard investigation for stratifying the risk of malignancy of a thyroid nodule. However, some limitations affect the adequacy of the obtained materials, resulting in 30% of the cytological results remaining in the indeterminate category. We aimed to investigate the diagnostic value of the BRAF mutation in cytologically indeterminate thyroid nodules after the reclassification of a variant thyroid carcinoma. Read More

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http://dx.doi.org/10.2147/OTT.S190001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391130PMC
February 2019

High expression of NUCB2 promotes papillary thyroid cancer cells proliferation and invasion.

Onco Targets Ther 2019 18;12:1309-1318. Epub 2019 Feb 18.

Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, PR China,

Background: NUCB2, a novel multifunctional protein containing several functional domains, was newly found to play important roles in many cancers, but its role in papillary thyroid cancer (PTC) is not well investigated. Therefore, our study was performed to explore the functions of NUCB2 in PTC.

Methods: NUCB2 protein level was analyzed by immunohistochemistry. Read More

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http://dx.doi.org/10.2147/OTT.S184560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388962PMC
February 2019
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Correlations of lncRNAs with cervical lymph node metastasis and prognosis of papillary thyroid carcinoma.

Onco Targets Ther 2019 18;12:1269-1278. Epub 2019 Feb 18.

Department of Endocrinology and Metabolism, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150080, China,

Background: Cervical lymph node metastasis is an important prognostic indicator for papillary thyroid carcinoma (PTC) and affects treatment strategies for PTC. lncRNAs essentially contribute to the biological functions of tumors. This study aimed to identify the lncRNAs associated with cervical lymph node metastasis and prognosis of PTC and their potential pathophysiological mechanisms. Read More

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http://dx.doi.org/10.2147/OTT.S191700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388952PMC
February 2019

Oncogenic properties of the antisense lncRNA COMET in BRAF- and RET-driven papillary thyroid carcinomas.

Cancer Res 2019 Mar 12. Epub 2019 Mar 12.

Institute Genetics and Biophysics, National Research Council

RET rearrangements as well as BRAF and RAS mutations drive differential pathway activation in papillary thyroid carcinomas, leading to different tumor phenotypes and prognoses. Although The Cancer Genome Atlas Consortium has identified tumor subgroups based on protein-coding gene signatures, neither expression of long non-coding RNAs (lncRNAs) nor their correlation with specific tumor-driving mutations and rearrangements have been systematically assessed. Here we reanalyzed our RNA-sequencing data using a de novo discovery approach to identify lncRNAs and define tumor subtype-specific signatures of annotated lncRNAs. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2520DOI Listing

The influence of thyroid nodule size on the diagnostic efficacy and accuracy of ultrasound guided fine-needle aspiration cytology.

Diagn Cytopathol 2019 Mar 12. Epub 2019 Mar 12.

Department of Endocrinology and Metabolism, Ankara University Faculty of Medicine, Ankara, Turkey.

Background: Diagnostic accuracy of fine-needle aspiration cytology (FNAC) in large and subcentimeter nodules is still debated. We aimed to evaluate the impact of nodule size on efficacy of the ultrasound-guided FNAC.

Methods: B-mode grayscale ultrasound (US), US-guided FNAC according to Bethesda system and histopathological data of 514 nodules from 371 patients, who underwent thyroidectomy were examined retrospectively. Read More

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http://doi.wiley.com/10.1002/dc.24170
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http://dx.doi.org/10.1002/dc.24170DOI Listing
March 2019
1 Read

Microscopic positive margins strongly predict reduced disease-free survival in pT4a papillary thyroid cancer.

Head Neck 2019 Mar 12. Epub 2019 Mar 12.

Department of Head and Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia.

Background: Although microscopic positive margins appear to have no independent prognostic impact in papillary thyroid cancer (PTC), this may not be the case in pT4a tumors.

Methods: Retrospective analysis of 610 patients with PTC, 39 with pT4a tumors, to determine if microscopic positive margins impact disease-free survival (DFS) in pT4a PTC.

Results: On univariate analysis, microscopic positive margins were not associated with reduced DFS in patients with no extrathyroidal extension (ETE) (hazard ratio [HR], 1. Read More

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http://dx.doi.org/10.1002/hed.25730DOI Listing

A rare invasion route for differentiated thyroid carcinoma: The tracheoesophageal common party wall.

Laryngoscope 2019 Mar 12. Epub 2019 Mar 12.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York, U.S.A.

Thyroid carcinoma can infiltrate the aerodigestive tract. Invasion via the common party wall of the tracheoesophageal groove (TEG) is rare. A review of patients with thyroid cancer invading the aerodigestive tract was performed. Read More

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http://dx.doi.org/10.1002/lary.27915DOI Listing
March 2019
1 Read

Transoral endoscopic thyroidectomy using vestibular approach: A single center experience.

J Postgrad Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Seth GS Medical College, Parel, Mumbai, Maharashtra, India.

Background: Thyroid Natural Orifice Transluminal Endoscopic Surgery (NOTES) or transoral endoscopic thyroidectomy using vestibular approach is a recent advance embraced by the surgical community because of its potential for a scar-free thyroidectomy. In this article, we present our initial experience with this technique.

Materials And Methods: We used a three-port technique through the oral vestibule, one 10 mm port for the laparoscope and two additional 5 mm ports for the endoscopic instruments required. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_117_18DOI Listing

Papillary microcarcinoma of the thyroid gland: current controversies and management.

Curr Opin Otolaryngol Head Neck Surg 2019 Mar 6. Epub 2019 Mar 6.

Department of Otorhinolaryngology - Head and Neck Surgery, Head, Neck and Thyroid Oncology Unit, Guy's and St Thomas' Hospital, London, UK.

Purpose Of Review: To highlight recent advances in our understanding of the nature of micropapillary thyroid carcinoma (mPTC), its evaluation and options of management based on risk.

Recent Findings: A dramatic increase of the incidence of papillary thyroid carcinoma has been reported worldwide during recent decades, specifically those smaller than 10 mm (mPTC). Although not taking into consideration other risk factors for aggressiveness when describing tumours by their size, most of these newly diagnosed mPTC are indolent and active surveillance can be considered as valid option for their management. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000520DOI Listing

NOB1: A potential biomarker or target in cancer.

Curr Drug Targets 2019 Mar 8. Epub 2019 Mar 8.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, LN. China.

Human NIN1/RPN12 binding protein 1 homolog (NOB1), an RNA binding protein, is expressed ubiquitously in normal tissues such as the lung, liver, and spleen. Its core physiological function is to regulate protease activities and participate in maintaining RNA metabolism and stability. NOB1 is overexpressed in a variety of cancers, including pancreatic cancer, non-small cell lung cancer, ovarian cancer, prostate carcinoma, osteosarcoma, papillary thyroid carcinoma, colorectal cancer, and glioma. Read More

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http://dx.doi.org/10.2174/1389450120666190308145346DOI Listing
March 2019
2 Reads

Papillary thyroid carcinoma in cervical lymph nodes with vanished thyroid gland after ablation of Graves' disease by radioactive iodine.

Ann R Coll Surg Engl 2019 Mar 11:e1-e3. Epub 2019 Mar 11.

Surgical Oncology Unit, Oncology Center Mansoura University , Mansoura , Egypt.

Primary thyroid carcinoma after thyroid ablation by radioactive iodine is rare. We present a very rare condition of lateral apparent papillary thyroid carcinoma eight years after receiving radioactive iodine for thyrotoxicosis, which led to complete anatomical and functional involution of the thyroid gland. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0033DOI Listing

Papillary thyroid carcinoma with bilateral axillary lymph node involvement: a case report outlining hypothesis for locoregional spread and therapeutic implications.

AME Case Rep 2019 24;3. Epub 2019 Jan 24.

Department of Surgery, University of Massachusetts Memorial Medical Center, Worcester, MA, USA.

Axillary lymph node involvement (ALNI) in well differentiated papillary thyroid carcinoma (WDPTC) is a rare sequela of disease presentation. We report a case of PTC with extensive cervical lymph node involvement, local extension to the skin of the neck and bilateral ALNI without evidence of distant disease. We posit that ALNI represents local extension of disease rather than distant metastasis. Read More

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http://dx.doi.org/10.21037/acr.2019.01.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378239PMC
January 2019

Quantitative Non-Gaussian Intravoxel Incoherent Motion Diffusion-Weighted Imaging Metrics and Surgical Pathology for Stratifying Tumor Aggressiveness in Papillary Thyroid Carcinomas.

Tomography 2019 Mar;5(1):26-35

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY.

We assessed a priori aggressive features using quantitative diffusion-weighted imaging metrics to preclude an active surveillance management approach in patients with papillary thyroid cancer (PTC) with tumor size 1-2 cm. This prospective study enrolled 24 patients with PTC who underwent pretreatment multi-b-value diffusion-weighted imaging on a GE 3 T magnetic resonance imaging scanner. The apparent diffusion coefficient (ADC) metric was calculated from monoexponential model, and the perfusion fraction (), diffusion coefficient (), pseudo-diffusion coefficient (), and diffusion kurtosis coefficient () metrics were estimated using the non-Gaussian intravoxel incoherent motion model. Read More

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http://dx.doi.org/10.18383/j.tom.2018.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403039PMC

Repeatability of Quantitative Diffusion-Weighted Imaging Metrics in Phantoms, Head-and-Neck and Thyroid Cancers: Preliminary Findings.

Tomography 2019 Mar;5(1):15-25

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY.

The aim of this study was to establish the repeatability measures of quantitative Gaussian and non-Gaussian diffusion metrics using diffusion-weighted imaging (DWI) data from phantoms and patients with head-and-neck and papillary thyroid cancers. The Quantitative Imaging Biomarker Alliance (QIBA) DWI phantom and a novel isotropic diffusion kurtosis imaging phantom were scanned at 3 different sites, on 1.5T and 3T magnetic resonance imaging systems, using standardized multiple b-value DWI acquisition protocol. Read More

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http://dx.doi.org/10.18383/j.tom.2018.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403035PMC

Recent advances in understanding immune phenotypes of thyroid carcinomas: prognostication and emerging therapies.

F1000Res 2019 28;8. Epub 2019 Feb 28.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy, Italy.

Tumors modulate the host immune cells within their microenvironment to avoid recognition and elimination by our immune system, a phenotype called cancer immune escape. Different mechanisms responsible for cancer immune escape that result either in decreased tumor immunogenicity or in increased tumor immunosuppressive activity have been identified. Recently, various immunotherapeutic approaches have been developed with the aim to revert tumor immune escape. Read More

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http://dx.doi.org/10.12688/f1000research.16677.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396838PMC
February 2019
1 Read

First report of in-situ preservation of a subcapsular parathyroid gland through super-meticulous capsular dissection during robotic radical thyroidectomy.

Surg Oncol 2019 Mar 26;28:9-13. Epub 2018 Oct 26.

Breast and Thyroid Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. Electronic address:

Purpose: Meticulous capsular dissection can preserve the function of the parathyroid gland in most patients, but it is difficult to identify and preserve the subcapsular parathyroid gland. We performed in-situ preservation of the subcapsular parathyroid gland during robotic radical thyroidectomy using super-meticulous capsular dissection, and evaluated its effect on postoperative parathyroid function.

Methods: A 45-year-old woman was admitted with bilateral thyroid nodules. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.10.009DOI Listing

Preoperative predictors and prognosis of bilateral multifocal papillary thyroid carcinomas.

Surg Oncol 2019 Mar 31;28:145-149. Epub 2018 Dec 31.

Yildirim Beyazit University, Ataturk Education and Research Hospital, Endocrinology and Metabolism Department, Ankara, Turkey. Electronic address:

Background: The characteristics of multifocal PTC remain controversial. Surgical approach to multifocal tumor changes between centers. This study aimed to evaluate the incidence of bilateral involvement, predictive factors for bilaterality and whether bilaterality was related with more aggressive histopathologic features or prognosis in patients with multifocal PTC. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.12.004DOI Listing
March 2019
2 Reads

Use of Delphian lymph node metastasis to predict central and lateral involvement in papillary thyroid carcinoma: A systematic review and meta-analysis.

Clin Endocrinol (Oxf) 2019 Mar 9. Epub 2019 Mar 9.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.

Objective: Whether Delphian lymph node (DLN) metastasis is a reliable predictor of widespread lymph node metastasis in papillary thyroid carcinoma (PTC) remains controversial. This meta-analysis investigated the value of DLN metastasis for predicting central and lateral involvement in PTC.

Design And Methods: A literature search using the PubMed, SCIE, and the Chinese National Knowledge Infrastructure (CNKI) databases was conducted. Read More

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http://dx.doi.org/10.1111/cen.13965DOI Listing
March 2019
3.457 Impact Factor

MAPK Inhibitors Enhance HDAC Inhibitor-Induced Redifferentiation in Papillary Thyroid Cancer Cells Harboring : An Study.

Mol Ther Oncolytics 2019 Mar 5;12:235-245. Epub 2019 Feb 5.

Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.

Clinical efficacy of redifferentiation therapy with histone deacetylase inhibitor (HDACi) for lethal radioiodine-refractory papillary thyroid cancer (RR-PTC) is urgently needed to be improved. Given that the impairment of histone acetylation is a mechanism in -mitogen-activated protein kinase (MAPK)-induced aberrant silencing of thyroid iodine-metabolizing genes, dual inhibition of HDAC and MAPK may produce a more favorable effect. In this study, we treated -mutant (BCPAP and K1) and -wild-type (BHP 2-7) cells with HDACi (panobinostat) and MAPK inhibitor (dabrafenib or selumetinib), alone or in combination, and we tested the expression of iodine- and glucose-metabolizing genes, radioiodine uptake and efflux, and toxicity. Read More

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http://dx.doi.org/10.1016/j.omto.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389779PMC

The POLR2E rs3787016 polymorphism is strongly associated with the risk of female breast and cervical cancer.

Pathol Res Pract 2019 Feb 27. Epub 2019 Feb 27.

Clinical Laboratory, Wuhan Xinzhou District People's Hospital, Wuhan, China. Electronic address:

The rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer. To prove the hypothesis, we here performed a case-control study to explore the association between rs3787016 and cervical cancer risk, and to confirm the association between rs3787016 and breast cancer in a central Chinese population, which was followed by a meta-analysis to precisely estimate the association between rs3787016 and risk of female breast and cervical cancer. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and confirmed by sequencing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183177
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http://dx.doi.org/10.1016/j.prp.2019.02.015DOI Listing
February 2019
4 Reads

Total thyroidectomy versus lobectomy for intermediate-risk papillary thyroid carcinoma: A single-institution matched-pair analysis.

Oral Oncol 2019 Mar 31;90:17-22. Epub 2019 Jan 31.

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center For Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, China. Electronic address:

Background: Total thyroidectomy (TT) is recommended by guidelines for intermediate-risk papillary thyroid carcinoma (PTC) but its survival advantage over lobectomy has not been proven. The aim of this study was to examine the association between the extent of surgery and the clinical outcome of patients with intermediate-risk PTC.

Methods: Adult patients with PTC in the institutional database from 1996 to 2008 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.010DOI Listing
March 2019
1 Read

Influence of the reclassification of NIFTP as a uncertain tumor on risk of malignancy for the diagnostic categories according to the Bethesda System for Reporting Thyroid Cytopathology.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Klinika Endokrynologii, Świętokrzyskie Centrum Onkologii, Kielce, Poland.

Purpose: The noninvasive encapsulated, follicular variant of papillary thyroid carcinoma was reclassified as Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). The exclusion of NIFTP from the group of malignant tumors decreases the risk of malignancy (RoM) as defined by the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The aim of the present study was to evaluate the RoM for each category in TBSRTC with and without exclusion of NIFTP from the tally of malignancies. Read More

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http://dx.doi.org/10.5603/EP.a2019.0008DOI Listing

Papillary microcarcinoma of the thyroid gland: current controversies and management.

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):110-116

Department of Otorhinolaryngology - Head and Neck Surgery, Head, Neck and Thyroid Oncology Unit, Guy's and St Thomas' Hospital, London, UK.

Purpose Of Review: To highlight recent advances in our understanding of the nature of micropapillary thyroid carcinoma (mPTC), its evaluation and options of management based on risk.

Recent Findings: A dramatic increase of the incidence of papillary thyroid carcinoma has been reported worldwide during recent decades, specifically those smaller than 10 mm (mPTC). Although not taking into consideration other risk factors for aggressiveness when describing tumours by their size, most of these newly diagnosed mPTC are indolent and active surveillance can be considered as valid option for their management. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000520DOI Listing

Preoperative serum VEGF-C but not VEGF-A level is correlated with lateral neck metastasis in papillary thyroid carcinoma.

Head Neck 2019 Mar 7. Epub 2019 Mar 7.

Department of Otorhinolaryngology-Head and Neck Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.

Background: This study aimed to investigate the relationships between serum vascular endothelial growth factor (VEGF)-A or VEGF-C levels and lymph node metastasis (LNM) status in patients with papillary thyroid carcinoma (PTC).

Methods: The study enrolled 150 patients with pathologically proven PTC who underwent surgery: PTC without LNM, PTC with central neck metastasis, and PTC with lateral neck metastasis.

Results: Preoperative serum VEGF-A levels were 300. Read More

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http://dx.doi.org/10.1002/hed.25729DOI Listing
March 2019
1 Read

Previously undescribed thyroid-specific miRNA sequences in papillary thyroid carcinoma.

J Hum Genet 2019 Mar 6. Epub 2019 Mar 6.

Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, Canada.

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, wherein diagnostic limitations and lack of accurate prognostic factors are important clinical challenges. In this study, we report the discovery of 234 novel miRNAs in non-neoplastic thyroid and PTC samples, obtained from publicly available small RNA sequencing datasets (TCGA and GEO). These sequences were observed to display similar molecular features compared to currently annotated miRNAs. Read More

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http://dx.doi.org/10.1038/s10038-019-0583-7DOI Listing
March 2019
1 Read

Cutaneous Metastasis of a Papillary Thyroid Carcinoma.

J Cutan Med Surg 2019 Mar/Apr;23(2):224

3 Department of Pathology, Hotel-Dieu de Quebec et CRCEO, Quebec City, QC, Canada.

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http://dx.doi.org/10.1177/1203475418800936DOI Listing

Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma.

Ann Otol Rhinol Laryngol 2019 Mar 6:3489419834314. Epub 2019 Mar 6.

1 Changzhou First People's Hospital, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background:: Epidemiologic studies have demonstrated an increased risk for papillary thyroid carcinoma (PTC) with increasing body mass index (BMI). However, the relationships between excess weight and the behavior of PTC are inconsistent. The aim of this study was to evaluate the impact of excess weight on clinicopathologic features of PTC and on patient outcomes. Read More

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http://dx.doi.org/10.1177/0003489419834314DOI Listing
March 2019
1 Read

Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy.

Int J Mol Sci 2019 Mar 5;20(5). Epub 2019 Mar 5.

College of Medicine, Touro University Nevada, 874 American Pacific Drive, Henderson, NV 89014, USA.

The diagnostic approach to thyroid cancer is one of the most challenging issues in oncology of the endocrine system because of its high incidence (3.8% of all new cancer cases in the US) and the difficulty to distinguish benign from malignant non-functional thyroid nodules and establish the cervical lymph node involvement during staging. Routine diagnosis of thyroid nodules usually relies on a fine-needle aspirate biopsy, which is invasive and often inaccurate. Read More

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http://dx.doi.org/10.3390/ijms20051114DOI Listing
March 2019
2 Reads

Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways.

Mol Carcinog 2019 Mar 4. Epub 2019 Mar 4.

IRCCS SDN, Napoli, Italy.

Junctional adhesion molecule A (JAM-A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM-A as one of the genes mostly deregulated. The quantitative real-time polymerase chain reaction and immunohistochemistry analyses showed that downregulation of JAM-A occurred in anaplastic thyroid carcinoma (ATC) compared with normal thyroid (NT) and papillary thyroid carcinoma (PTC) tissues and correlated with extrathyroid infiltration, tumor size, and ATC histotype. Read More

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http://dx.doi.org/10.1002/mc.23001DOI Listing

MicroRNA-101 targets CXCL12-mediated Akt and Snail signaling pathways to inhibit cellular proliferation and invasion in papillary thyroid carcinoma.

Oncol Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathophysiology, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450008, China.

Escalating evidence suggests that microRNA-101 (miR-101) implicates in the development and progression of various cancers, including papillary thyroid carcinoma (PTC). However, the biological function and molecular mechanisms of miR-101 in PTC are still unclear. In this study, we demonstrated that miR-101 expression was significantly decreased in PTC tissues and cell lines. Read More

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http://dx.doi.org/10.3727/096504018X15426763753594DOI Listing