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    16284 results match your criteria Thyroid Papillary Carcinoma

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    The Significance of TROP2 Expression in Predicting BRAF Mutations in Papillary Thyroid Carcinoma.
    J Pathol Transl Med 2017 Dec 11. Epub 2017 Dec 11.
    Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea.
    Background: Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that is overexpressed in several types of epithelial cancers, and is suggested to be associated with an unfavorable prognosis. BRAF mutations are the most common genetic alteration in papillary thyroid carcinoma (PTC). We evaluated the correlation between TROP2 expression and BRAF mutation in PTC. Read More

    Clinical implications of pathologic factors after thyroid lobectomy in patients with papillary thyroid carcinoma.
    Oral Oncol 2017 Dec 18;75:1-5. Epub 2017 Oct 18.
    Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Objective: We evaluated the clinical and prognostic significance of pathologic factors by analyzing the treatment results of patients who underwent thyroid lobectomy.

    Materials And Methods: We retrospectively analyzed data from 734 patients diagnosed with papillary thyroid cancer who underwent thyroid lobectomy at Korea University Hospital from January 2004 to December 2016.

    Results: A total of 734 patients were included in the study and their mean age was 44. Read More

    Tumor-suppressive function of UNC5D in papillary thyroid cancer.
    Oncotarget 2017 Nov 10;8(56):96126-96138. Epub 2017 Oct 10.
    The Core Laboratory in Medicine Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
    Background: Studies have shown an association of the UNC5D gene with kidney and bladder cancer and neuroblastoma. We investigated whether UNC5D acts as a tumor suppressor in papillary thyroid carcinoma (PTC).

    Methods: Primary PTC tumors and matched normal thyroid tissues were obtained from 112 patients to detect UNC5D mRNA by real-time PCR. Read More

    Inhibition of X-linked inhibitor of apoptosis protein suppresses tumorigenesis and enhances chemosensitivity in anaplastic thyroid carcinoma.
    Oncotarget 2017 Nov 28;8(56):95764-95772. Epub 2017 Sep 28.
    The Fourth Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
    Anaplastic thyroid carcinoma (ATC) is one of the most lethal carcinoma with a poor prognosis; however, molecular mechanisms underlying the aggressiveness of ATC remain unclear. Our goal was to examine the expression of X-linked inhibitor of apoptosis protein (XIAP) in ATC, as well as its role in ATC tumorigenesis. This is a retrospective study of ATC patients from the Second Affiliated Hospital of Harbin Medical University during June 2003 to October 2013. Read More

    MassARRAY-based simultaneous detection of hotspot somatic mutations and recurrent fusion genes in papillary thyroid carcinoma: the PTC-MA assay.
    Endocrine 2017 Dec 6. Epub 2017 Dec 6.
    Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
    Purpose: We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid cancer (PTC).

    Methods: The assay was developed using DNA and cDNA from 12 frozen and 11 formalin-fixed paraffin embedded samples from 23 PTC cases, together with positive and negative controls.

    Results: The PTC-MA assay displays high sensitivity towards point mutations and gene rearrangements, detecting their presence at frequencies as low as 5%. Read More

    "Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features" With Focal Spindle Cell Metaplasia.
    Int J Surg Pathol 2017 Dec 1:1066896917741548. Epub 2017 Dec 1.
    1 Geneva University Hospital, Geneva, Switzerland.
    "Noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) is a recent reclassification of the encapsulated follicular variant of papillary thyroid carcinoma, which is supposed to reflect its indolent clinical behavior and to prevent overtreatment of patients with this neoplasm. The diagnosis of NIFTP can only be made histologically on the surgical specimen according to specific inclusion and exclusion criteria, which requires the examination of the whole nodule and its capsule. Spindle cell proliferations, especially of follicular cell origin, arising within thyroid follicular neoplasms are very rare and may cause diagnostic difficulties. Read More

    BRAF-Oncogene-Induced Senescence and the Role of Thyroid-Stimulating Hormone Signaling in the Progression of Papillary Thyroid Carcinoma.
    Horm Cancer 2017 Dec 5. Epub 2017 Dec 5.
    The Biochemistry and Molecular Biology unit, Department of Chemistry, Faculty of Science, University of Colombo, Colombo, Sri Lanka.
    Oncogene-induced senescence (OIS) explains the phenomenon of cellular senescence triggered by the action of oncogenes. It is a mechanism adopted by a cell to inhibit progression of benign tumors into malignancy, occurs in premalignant lesions, and is almost never present in malignant lesions. BRAF mutations occur in about 40-45% of all papillary thyroid carcinomas (PTCs) and of which 99. Read More

    Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?
    Endocrine 2017 Dec 4. Epub 2017 Dec 4.
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
    Objective: In 2016, non-invasive, well-circumscribed and encapsulated, follicular variant of papillary thyroid carcinoma (NI-EFV PTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, the study cohort did not include subcentimeter tumors, i.e. Read More

    p63 inhibits CD44+/CD24- cell proliferation and chemoresistance in papillary thyroid carcinoma cells.
    Exp Ther Med 2017 Nov 19;14(5):4693-4696. Epub 2017 Sep 19.
    Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
    Thyroid cancer typically has a good prognosis; however, the risks of recurrence and chemoresistance associated with thyroid cancer remain a cause for concern. Papillary thyroid carcinoma (PTC) comprises 80% of all cases of thyroid carcinoma. A previous study reported that cluster of differentiation (CD) 44+/CD24- PTC cells may contribute to PTC recurrence and chemoresistance; however, the underlying molecular mechanisms remain elusive. Read More

    Endocrine and metabolic assessment in adults with Langerhans cell histiocytosis.
    Eur J Intern Med 2017 Nov 29. Epub 2017 Nov 29.
    U.O. di Endocrinologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Comunità, Università di Milano, Milan, Italy.
    Context: Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly defined yet.

    Objectives: Evaluate prevalence of endocrine and metabolic manifestations in a cohort of patients affected by Pulmonary LCH.

    Methods: Observational cross-sectional study on 18 adults (7 M/11 F, 42±12years) studied for complete basal and dynamic endocrine lab tests and glucose metabolism. Read More

    Harefuah 2017 11;156(11):682-685
    Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center, Beilinson Campus, Petach Tikva.
    Aims: To review the experience of a single-center with RATS and to assess its outcome, feasibility and safety.

    Background: With the advent of minimally invasive techniquesin thyroid surgery, robot-assisted transaxillary thyroid surgery (RATS) has become one of the most popular approaches. Its main advantages are improved cosmetic outcome, thereby increasing patient satisfaction, improved visualization and range of motion. Read More

    Does noninvasive follicular thyroid neoplasm with papillary-like nuclear features have distinctive features on sonography?
    Diagn Cytopathol 2017 Nov 29. Epub 2017 Nov 29.
    Department of Pathology, New York University School of Medicine, New York.
    Background: The noninvasive encapsulated follicular variant of papillary carcinoma (nEFVPTC) has recently been reclassified to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)," removing this entity from the malignant category. This re-categorization has had major implications for clinical management. NIFTP has overlapping cytohistologic features with papillary thyroid carcinoma (PTC) and with follicular adenomas (FA), but sonographic data comparing NIFTP to PTC and FA is lacking. Read More

    Implementing noninvasive follicular thyroid neoplasm with papillary-like nuclear features may potentially impact the risk of malignancy for thyroid nodules categorized as AUS/FLUS and FN/SFN.
    Diagn Cytopathol 2017 Nov 30. Epub 2017 Nov 30.
    Department of Pathology, The University of Michigan Health System, Ann Arbor, Michigan.
    Background: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).

    Methods: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections. Read More

    Clinical Significance of a Solitary Cold Thyroid Nodule in the Setting of Graves Disease.
    Clin Nucl Med 2018 Jan;43(1):e27-e28
    From the Nuclear Medicine Service, James A. Haley Veterans' Hospital & Clinics; and University of South Florida Morsani College of Medicine, Tampa, FL.
    I-NaI thyroid uptake and scan in a 46-year-old woman with symptomatic hyperthyroidism demonstrated marked, diffusely increased uptake consistent with Graves disease, as well as a solitary hypofunctioning ("cold") nodule. Pathologic evaluation following total thyroidectomy and selective neck dissection revealed invasive multifocal papillary thyroid carcinoma in a background of Graves disease and 5 of 36 lymph nodes positive for metastatic disease. This case serves as a reminder that when present a cold nodule in the setting of Graves disease warrants further evaluation for underlying malignancy. Read More

    The role of laryngectomy in locally advanced thyroid carcinoma. Review of 16 cases.
    Acta Otorhinolaryngol Ital 2017 Nov 30. Epub 2017 Nov 30.
    School of Medicine, Universidad de Antioquia, Fundación Colombiana de Cancerología Clínica Vida, Medellín, Colombia.
    Locally advanced disease with larynx invasion is a challenge to the surgeon, but laryngectomy is almost never necessary in thyroid carcinoma. The aim of this study was to review the clinical outcomes of patients with locally advanced thyroid carcinoma invading the larynx who underwent laryngectomy. A case series of patients treated in a tertiary care hospital was reviewed. Read More

    Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel.
    Food Funct 2017 Nov 29. Epub 2017 Nov 29.
    School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China.
    Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Recently, capsaicin has attracted increasing attention owing to its multiple biological activities. However, the anticancer effects of capsaicin against various types of cancers, especially on thyroid carcinoma, have not been completely elucidated. Read More

    Feasibility of sentinel lymph node dissection using Tc-99m phytate in papillary thyroid carcinoma.
    Ann Surg Treat Res 2017 Nov 27;93(5):240-245. Epub 2017 Oct 27.
    Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
    Purpose: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC). Read More

    The Hobnail variant of Papillary Thyroid Carcinoma: clinical/molecular characteristics of a large monocentric series and comparison with conventional histotypes.
    Thyroid 2017 Nov 27. Epub 2017 Nov 27.
    University of Padua, Endocrinology Unit, Department of Medicine, Padua, Italy ;
    Background: The hobnail variant of papillary thyroid carcinoma (HPTC) has an aggressive behavior. The aims of this prospective study were to define the clinical/molecular characteristics of HPTC, and to compare them with those of conventional papillary thyroid carcinoma (PTC).

    Methods: From 2010 to 2016, we treated 25 cases of HPTC, characterized clinically and molecularly (BRAF, RAS, TERT promoter and TP53), which were compared with a series of 165 consecutive cases of PTC. Read More

    Is Doppler ultrasonography of value for the differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma (iEFVPTC)?
    Clin Endocrinol (Oxf) 2017 Nov 25. Epub 2017 Nov 25.
    Instituition: Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    Recently, the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) received the name "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) and was no longer considered "cancer".1 Furthermore, the treatment recommendations for differentiated thyroid cancer no longer apply to NIFTP, which is sufficiently treated by lobectomy only.1 The probability that a thyroid nodule corresponds to NIFTP has become of great interest in clinical practice, since it would at least influence the extent of surgery. Read More

    Evaluation of Incidental Thyroid Nodules in Cancer Patients.
    J Natl Med Assoc 2017 Winter;109(4):299-306. Epub 2017 Apr 20.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Akdeniz University School of Medicine, Antalya, Turkey.
    Objective: Frequency of thyroid cancer in incidental thyroid nodules identified by imaging techniques in cancer patients is higher than that in the normal population. In the retrospective study, we have both investigated the incidence of thyroid cancer in incidentally identified nodules and compared the imaging techniques to determine whether there is any difference between them in detection of malign nodules.

    Methods: A total of 7319 patients who underwent thyroid fine-needle aspiration biopsy (FNAB) were included in the study. Read More

    [An ovarian tumor can hide another one].
    Ann Pathol 2017 Dec 21;37(6):479-483. Epub 2017 Nov 21.
    Service d'anatomie et cytologie pathologiques, hôpital de la Timone, 254, rue Saint-Pierre, 13005 Marseille, France.
    We report the case of a 33-year-old woman who went under surgery for a cystic mature teratoma. The histological exam found two cysts, one was a mature teratoma and the other was a struma ovarii with a papillary carcinomatous element. Struma ovarii cancerization is seen in 5 to 10% of the cases usually under a papillary carcinoma type. Read More

    AKT activity is elevated in aggressive thyroid neoplasms where it promotes proliferation and invasion.
    Exp Mol Pathol 2017 Dec 21;103(3):288-293. Epub 2017 Nov 21.
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, USA. Electronic address:
    The PI3K/AKT/mTOR signaling pathway controls major cellular processes such as cell growth, proliferation and survival. Stimulation of this pathway leads to AKT phosphorylation and activation, resulting in phosphorylation of mTOR and myriad other targets. AKT upregulation has been implicated in thyroid cancer pathogenesis and is a candidate treatment target for patients with advanced disease that has not responded to traditional therapies. Read More

    Long-term efficacy and safety of fourth-line multikinase inhibitor treatment with lenvatinib in a young papillary thyroid carcinoma patient.
    Drugs Context 2017 26;6:212310. Epub 2017 Jul 26.
    Dipartimento di Medicina, Università degli Studi di Perugia, Edificio D, piano +2, Piazza L. Severi 1, 06132 Perugia, Italy.
    Lenvatinib, a multikinase inhibitor, is approved for the treatment of patients with radioiodine-refractory metastatic thyroid cancer on the basis of a Phase III, prospective, double-blind, randomized, placebo-controlled trial that showed longer progression-free survival in the drug-treated arm. Here, we report the case of a young papillary thyroid cancer patient, pretreated with three other kinase inhibitors, who achieved a long-term clinical benefit from lenvatinib in the fourth-line setting. Read More

    Pre-operative features of non-invasive follicular thyroid neoplasms with papillary-like nuclear features: An analysis of their cytological, Gene Expression Classifier and sonographic findings.
    Cytopathology 2017 Dec;28(6):488-494
    Department of Pathology & Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.
    Objective: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology.

    Methods: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1st April 2016 and 1st April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen. Read More

    Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients.
    Acta Otorhinolaryngol Ital 2017 Oct;37(5):393-400
    Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Liaoning Province, People's Republic of China.
    Papillary thyroid carcinoma (PTC) is the most common malignant tumour of the thyroid. The effect of the concurrent presence of Hashimoto's thyroiditis (HT) and PTC is still under debate. The aim of this study is to investigate the influence of coexistent HT on prognostic outcomes and the association of coexistent HT with clinicopathological features. Read More

    Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.
    Oncol Lett 2017 Dec 26;14(6):6485-6496. Epub 2017 Sep 26.
    Division of Pathology Diagnostic Services, Cytology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
    Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. Read More

    Sorafenib treatment for papillary thyroid carcinoma with diffuse lung metastases in a child with autism spectrum disorder: a case report.
    BMC Cancer 2017 Nov 21;17(1):775. Epub 2017 Nov 21.
    Department of Pediatrics, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-refractory thyroid carcinoma in adults; however, pediatric experience is limited. Medical procedures and hospitalization for children with autism spectrum disorder may be challenging. Read More

    Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer.
    Case Rep Oncol Med 2017 12;2017:4276435. Epub 2017 Oct 12.
    Department of Hematology Oncology, SUNY Upstate Medical University, Syracuse, NY 13205, USA.
    Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. Read More

    Mixed subtype thyroid cancer: A surveillance, epidemiology, and end results database analysis.
    Oncotarget 2017 Oct 23;8(49):86556-86565. Epub 2017 Sep 23.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
    The prognosis of patients with mixed subtype thyroid cancer (MSTC) is unclear. The present study compared the prognoses of MSTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC) to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Read More

    Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAFV600E.
    Oncotarget 2017 Oct 24;8(49):84743-84760. Epub 2017 Sep 24.
    Laboratory of human thyroid cancers preclinical and translational research, Division of Experimental Pathology, Cancer Research Institute, Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
    Purpose: Papillary thyroid carcinoma (PTC) is the most frequent endocrine tumor. BRAFV600E represents the PTC hallmark and is targeted with selective inhibitors (e.g. Read More

    Tall cell variant of papillary breast carcinoma: an additional case with review of the literature.
    Pathologica 2017 Sep;109(3):162-167
    Division of Anatomic Pathology, Hospital "San Giacomo", Novi Ligure (AL), Italy.
    Papillary lesions of the breast can be one of the most challenging aspects of mammary pathology because of a wide morphologic spectrum that may be encountered in these lesions. An unusual breast tumor has been first classified as "breast tumor resembling the tall cell variant of papillary thyroid carcinoma" and subsequently renamed "tall cell variant of papillary breast carcinoma". To our knowledge, only 13 cases of this neoplasm have been reported so far. Read More

    Four synchronous primary cancers of the aerodigestive tract and thyroid.
    Asian Cardiovasc Thorac Ann 2017 Nov 19;25(9):645-648. Epub 2017 Nov 19.
    Department of Thoracic Surgery, 12570 Xiangya Hospital of Central South University , Changsha, Hunan, China.
    We report the case of a 60-year-old man with 4 concurrent primary cancers: thyroid papillary carcinoma, esophageal squamous cell carcinoma, lung adenocarcinoma, gastric stromal tumor, and nodular goiter. A minimally invasive McKeown esophagectomy with 3-field lymph node resection played a major role in the diagnosis and resection of all primary tumors in the same sitting. Multiorgan primary cancers are not uncommon but pose challenges in diagnosis and treatment. Read More

    HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid.
    Oncol Lett 2017 Dec 15;14(6):6505-6510. Epub 2017 Sep 15.
    Longnan Hospital of Daqing City, Daqing, Heilongjiang 163453, P.R. China.
    We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (papillary carcinoma group) and follicular differentiated thyroid carcinoma (follicular carcinoma group) to investigate the differences in expression of HBME-1. We further analyzed the correlation of the expression of HBME-1 in the papillary carcinoma group and the follicular carcinoma group with ultrasonic manifestation of thyroid. Read More

    [Analysis of Incidence and Mortality of Thyroid Cancer in China, 2013].
    Zhonghua Zhong Liu Za Zhi 2017 Nov;39(11):862-867
    Department of Thoracic Surgery, National Cancer Centre/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Objective: To evaluate the incidence and mortality status of thyroid cancer in China, 2013. Methods: Incidence and mortality data of thyroid cancer were derived from 255 population-based cancer registries in China. Age-specific and age standardized incidence and mortality rates of thyroid cancer in different areas (urban and rural) with different gender were calculated based on the stratification of area (urban and rural), gender, age and tumor position. Read More

    Associations Between Nucleus Size, and Immunohistochemical Galectin-3, Cytokeratine-19 and Hbme-1 Markers in Thyroid Papillary Carcinoma: A Morphometric Analyze.
    Pathol Oncol Res 2017 Nov 17. Epub 2017 Nov 17.
    Department of Pathology, Antalya Education and Research Hospital, Antalya, Turkey.
    This study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining. Read More

    Evaluating the projected surgical impact of reclassifying noninvasive encapsulated follicular variant of papillary thyroid cancer as noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Surgery 2017 Nov 13. Epub 2017 Nov 13.
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Institute for Technology Assessment, Boston, MA. Electronic address:
    Background: The reclassification of noninvasive encapsulated follicular variant of papillary thyroid cancer to noninvasive follicular thyroid neoplasm with papillary-like nuclear features will reduce nonefficacious and potentially harmful care. Reclassification is estimated in 18.6% of patients with papillary thyroid carcinoma; we aimed to quantify the implications of this change. Read More

    Partially cystic thyroid nodules in ultrasound-guided fine needle aspiration: Prevalence of thyroid carcinoma and ultrasound features.
    Medicine (Baltimore) 2017 Nov;96(46):e8689
    aDepartment of Ultrasound bDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Partially cystic thyroid nodules (PCTNs) are common on ultrasound (US). However, there are insufficient data on the prevalence of thyroid carcinoma among such nodules. The purpose of this study was thus to evaluate the prevalence and differentiation of partially cystic thyroid cancers in US-guided fine needle aspiration (FNA). Read More

    Endocr Pract 2017 Nov 16. Epub 2017 Nov 16.
    From: Department of Endocrinology, Diabetes and Metabolism.
    Objective: Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient.

    Methods: The literature search was performed through www. Read More

    Genetic landscape of papillary thyroid carcinoma in the Chinese population.
    J Pathol 2017 Nov 16. Epub 2017 Nov 16.
    Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
    Improvement in the clinical outcome of human cancers requires characterization of genetic alterations underlying their pathogenesis. Large-scale genomic and transcriptomic characterization of papillary thyroid carcinomas (PTCs) in Western populations has revealed multiple oncogenic drivers which are essential for understanding pathogenic mechanisms of this disease; while so far, the genetic landscape in Chinese patients with PTC remains uncharacterized. Here, we conducted a largescale genetic analysis of PTCs from patients in China to determine the mutational landscape of this cancer. Read More

    Single port thoracoscopic treatment of thoracic duct injury after thyroidectomy with neck dissection.
    Gland Surg 2017 Oct;6(5):598-601
    Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Chylous leakage is a complication of thyroidectomy accompanied by bilateral neck dissection with incidence of 0.5-6.2%. Read More

    Skin metastasis on the neck: an unusual presentation of recurrence of papillary thyroid carcinoma.
    Gland Surg 2017 Oct;6(5):594-597
    Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old. Read More

    Two-stage thyroidectomy in the era of intraoperative neuromonitoring.
    Gland Surg 2017 Oct;6(5):453-463
    Department of Endocrine Surgery, Central Clinic of Athens, Athens, Greece.
    Background: The use of intraoperative neuromonitoring (IONM) provides surgeons with real time information about recurrent laryngeal nerves (RLN) functional integrity. Hence, allowing them to modify the initially scheduled bilateral procedure, to a two-stage thyroidectomy in cases of loss of signal (LOS) on the first side of resection resulting in minimization of bilateral RLN injury. The purpose of our study was to present our results since the implementation of the above mentioned process in both malignant and benign thyroid disease. Read More

    [The difference expression and diagnostic value of RPL5 in papillary thyroid carcinoma of children and adults].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;52(11):830-834
    Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
    Objective: To study the difference expression and diagnostic value of ribosomal protein L5 (RPL5) in papillary thyroid carcinoma (PTC) of children and adults. Methods: Realtime-PCR was performed to detect the expression of RPL5 in 22 PTC tissues and 13 pericarcinous tissues. Receiver operating characteristic (ROC) curve and Youden's index were used to evaluate the diagnostic value of RPL5 in PTC of children and adults. Read More

    Pathologic basis of the sonographic differences between thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Ultrasonography 2017 Aug 19. Epub 2017 Aug 19.
    Lenox Hill Radiology, New York, NY, USA.
    Ultrasonography is pivotal in triage thyroid biopsy in the era after the identification of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). This pictorial essay illustrates the pathologic basis of the sonographic features that distinguish NIFTP from thyroid cancers. In this study, we present the correlations of ultrasonography to ×1 histopathology to assess shape and margin characteristics. Read More

    MiR-324-5p assists ultrasonography in predicting lymph node metastasis of unifocal papillary thyroid microcarcinoma without extracapsular spread.
    Oncotarget 2017 Oct 31;8(48):83802-83816. Epub 2017 Jul 31.
    Department of Ultrasonography, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Ultrasonography is the first choice of lymph node metastasis (LNM) detection which is crucial for therapeutic options of papillary thyroid cancer (PTC). However, the sensitivity of ultrasonography in detecting LNM of PTC is relatively low; especially in central LNM. MiR-324-5p has been reported to play important roles in the metastasis of various cancers. Read More

    Clinical outcomes and prognostic factors of radioiodine ablation therapy for lymph node metastases from papillary thyroid carcinoma.
    Nucl Med Commun 2018 Jan;39(1):22-27
    Department of Radiation Oncology, the First Affiliated Hospital of Zhengzhou University.
    Objective: A total of 118 patients with papillary thyroid carcinoma treated with radioactive iodine for lymph node metastases were analyzed retrospectively between August 2008 and June 2014. We describe the clinical course of these patients and focus on factors associated with lymph node metastases response to iodine-131 (I) treatment.

    Patients And Methods: A total of 118 postoperative papillary thyroid carcinoma patients who underwent I treatment with lymph nodes as the only site of metastasis on whole-body scan (I Rx-WBS) and single-photon emission computed tomography-computed tomography (SPECT-CT) were enrolled. Read More

    False-negative BRAF V600E mutation results on fine-needle aspiration cytology of papillary thyroid carcinoma.
    World J Surg Oncol 2017 Nov 13;15(1):202. Epub 2017 Nov 13.
    Department of Pathology, Chung-Ang University Hospital and Chung-Ang University College of Medicine, Seoul, South Korea.
    Background: The BRAF V600E mutation is highly specific for papillary thyroid carcinoma (PTC). A test for this mutation can increase the diagnostic accuracy of fine-needle aspiration cytology (FNAC), but a considerably high false-negative rate for the BRAF V600E mutation on FNAC has been reported. In this study, we investigated the risk factors associated with false-negative BRAF V600E mutation results on FNAC. Read More

    Back so soon? Is early recurrence of papillary thyroid cancer really just persistent disease?
    Surgery 2017 Nov 8. Epub 2017 Nov 8.
    Division of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI.
    Background: Papillary thyroid carcinoma has excellent survival, yet recurrence remains a challenge. We sought to determine the proportion of reoperations performed for persistent, rather than truly recurrent, disease.

    Methods: We conducted a retrospective review of a prospectively maintained database. Read More

    New terminology-noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) and its effect on the rate of malignancy at a single institution.
    Surgery 2017 Nov 7. Epub 2017 Nov 7.
    Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN.
    Background: The cytologic qualities of noninvasive follicular neoplasm with papillary-like nuclear features mimic papillary thyroid carcinoma (PTC) on fine-needle aspiration, leading to difficulty in distinguishing the 2 preoperatively. The aim of this study was to determine the impact of reclassification of noninvasive follicular neoplasm with papillary-like nuclear features at our practice.

    Methods: We searched 1,046 patient charts for those cases with preoperative cytology and subsequent follicular-variant papillary thyroid carcinoma diagnosis on resection. Read More

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