Search our Database of Scientific Publications and Authors

I’m looking for a

    15824 results match your criteria Thyroid Papillary Carcinoma

    1 OF 317

    Latero-cervical lymph node metastases (N1b) represent an additional risk factor for papillary thyroid cancer outcome.
    J Endocrinol Invest 2017 Jun 23. Epub 2017 Jun 23.
    Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Via Palermo 636, 95122, Catania, Italy.
    Purpose: Papillary thyroid carcinoma (PTC), the most common thyroid cancer histotype, has a good prognosis even when spread to the neck lymph node (LN). The prognostic role of LN metastases' location is still controversial. The aim of the present study was to evaluate the clinical relevance of the number and location of LN metastases at presentation in PTCs. Read More

    Correlation between BRAF (V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma.
    Sci China Life Sci 2017 Jun 15. Epub 2017 Jun 15.
    Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
    In adults, the presence of the BRAF (V600E) mutation in papillary thyroid cancer (PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF (V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF (V600E) mutation in 48 pediatric patients with PTC, aged 3-13 years. Read More

    Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors.
    Int J Endocrinol 2017 31;2017:4208178. Epub 2017 May 31.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University, Keelung, Taiwan.
    A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinical features between 626 multifocal and 1,910 solitary PTC cases showed that patients in the multifocal PTC group were older and had a smaller mean tumor size, a more advanced tumor-node-metastasis (TNM) stage, and a higher percentage of nonremission status compared to patients in the solitary PTC group. Read More

    Inclusion Body Myositis: A Case Presenting with Respiratory Failure and Autopsy Findings Leading to the Hypothesis of a Paraneoplastic Cause.
    Am J Case Rep 2017 Jun 23;18:700-706. Epub 2017 Jun 23.
    SUNY Downstate Medical Center, Brooklyn, NY, USA.
    BACKGROUND Sporadic inclusion body myositis (IBM) is the most common acquired myopathy seen in adults aged over 50 years, with a prevalence estimated at between 1 and 70 per million. Weakness of the diaphragm with loss of vital capacity is almost universal in IBM. This is almost always asymptomatic. Read More

    RAS-positive thyroid nodules.
    Curr Opin Endocrinol Diabetes Obes 2017 Jul 20. Epub 2017 Jul 20.
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, The Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: The current review focuses on the uncertainty regarding the management of rat sarcoma viral oncogene homolog RAS-positive thyroid nodules. The application of oncogene testing has been heralded for improving risk assessment for indeterminate cytology thyroid nodules and has grown in clinical use. RAS mutations are historically considered oncogenic. Read More

    Endotracheal Leiomyoma Mimicking Malignancy on 18F-FDG PET/CT in a Patient With Papillary Thyroid Carcinoma.
    Clin Nucl Med 2017 Jun 20. Epub 2017 Jun 20.
    From the Departments of *Nuclear Medicine, †Otorhinolaryngology, and ‡Pathology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
    Endotracheal leiomyoma is a rare benign lesion, accounting for approximately 1% of tracheal tumors, and generally occurs in the lower respiratory tract. Because its growth causes airway obstruction symptom, surgical treatment is generally suggested after detection. We report a case with leiomyoma of the cervical endotracheal space showing intense FDG uptake on F-FDG PET/CT mimicking malignancy in a 79-year-old woman with papillary thyroid carcinoma. Read More

    Discovery of novel wtRET and V804MRET inhibitors: from hit to lead.
    ChemMedChem 2017 Jun 22. Epub 2017 Jun 22.
    University of Padova, Pharmaceutical Sciences, via Marzolo 5, I-35131, Padova, ITALY.
    Oncogenic activation of the RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma and non-small cells lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wtRET and its mutants (e. Read More

    Accuracy of Fine Needle Cytology in Histological Prediction of Papillary Thyroid Carcinoma Variants: a Prospective Study.
    Endocr Pathol 2017 Jun 21. Epub 2017 Jun 21.
    Clinical Cytopathology Service, Institute of Pathology, via A. Franzoni - 45, 6601, Locarno, Switzerland.
    Fine needle cytology (FNC) is a crucial procedure in the preoperative diagnosis of thyroid tumors. Papillary thyroid carcinoma (PTC), in its classic variant (cPTC), is the most common malignant neoplasm of the thyroid. Several histological variants of PTC have been described, each one with its own characteristics and prognosis. Read More

    Surgical management for follicular variant of papillary thyroid carcinoma.
    Oncotarget 2017 Jun 16. Epub 2017 Jun 16.
    Department of Breast and Thyroid Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. China.
    Background And Aims: For most patients with follicular variant of papillary thyroid carcinoma (FVPTC), surgery is required, while the surgical management remains controversial. We aim to further understanding of treatment of FVPTC and to determine whether specific features could be identified for the decision of surgical strategy.

    Materials And Methods: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program database during 2003 and 2013. Read More

    [RET/PTC rearrangement affects multifocal formation of papillary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):435-439
    Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
    Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors. Methods: From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Read More

    [Retrospective comparison of screening criteria for active surveillance for papillary thyroid microcarcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):430-434
    Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
    Objective: To investigate the rationality of management of active surveillance for papillary thyroid microcarcinoma (PTMC) and the main indications for active surveillance for PTMC. Methods: In this study, two criteria were used to evaluate patients with PTMC: low-risk PTMC conditions defined by Kuma hospital and Chinese Association of Thyroid Oncology (CATO) consensus on PTMC management of active surveillance. The patients had received surgical treatment. Read More

    [Clinicopathological characteristics of papillary thyroid microcarcinoma and risk factors for central lymph node metastasis].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):426-429
    Department of Thyroid and Breast Surgery, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
    Objective: To analyze the clinicopathological characteristics of papillary thyroid microcarcinoma (PTMC) and risk factors for central lymph node metastasis(CLNM) in PTMC. Methods: The data of 900 patients with PTMC initially treated in our hospital from January 2004 to December 2015 were retrospectively analyzed. Chi-square test and Logistic regression analysis were performed to determine the risk factors for CLNM. Read More

    [Risk factors for central neck lymph node metastases of papillary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):421-425
    Department of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
    Objective: To investigate the impact factors for central neck lymph node metastases(CLNM) of papillary thyroid carcinoma(PTC). Methods: A total of 498 patients with PTC who underwent total or hemi-thyroidectomy plus central neck lymph node dissection between January 2014 and July 2016 were included. Univariate and multivariate analyses were performed to identify clinicopathological characteristics, thyroid function parameters and US findings that associated with CLNM of PTC. Read More

    [Clinical features of postoperative cervical lymph nodes recurrence in papillary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):416-420
    Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Beijing 100021, China.
    Objective: To analyse the postoperative metastasis or recurrence of cervical lymph nodes in individual neck levels for papillary thyroid carcinoma and to evaluate the outcomes and complications of re-surgery. Methods: A retrospective cohort study of 259 patients who underwent lymph node dissection for PTC relapse from January 2010 to June 2011. Lymph node metastases in each of neck levels were detected, postoperative complications were evaluated, and the patients were followed up with examining thyroglobulin levels to assess the therapeutic effect. Read More

    Atypical Histiocytoid Cells in Metastatic Papillary Thyroid Carcinoma An Underrecognized Cytologic Pattern.
    Am J Clin Pathol 2017 Jun 15. Epub 2017 Jun 15.
    Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.
    Objectives: Fine-needle aspiration (FNA) of head and neck lymph nodes (LNs) is useful in diagnosing metastatic papillary thyroid carcinoma (PTC) and most commonly shows classic cytologic features of PTC. Metastatic PTC, however, may occasionally present with a pattern unfamiliar to most pathologists: atypical histiocytoid cells (AHCs).

    Methods: All PTC thyroidectomy specimens with associated FNA of LNs were retrieved from our files for 2007 to 2013. Read More

    [BRAF-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer].
    Arkh Patol 2017 ;79(3):27-33
    Academician B.V. Petrovsky Russian Surgery Research Center, Moscow, Russia.
    To paper describes a case of paucicellular anaplastic cancer in the presence of tall cell variant papillary thyroid carcinoma. Microscopic examination showed that the differentiated component of the tumor was composed of papillary structures with tall cells, the height of which exceeded 3-4 times the width. Its anaplastic component consisted of fibrous tissue with occasional spindle-shaped cells and focal lymphocytic infiltration to the extent of 70%. Read More

    Poorly differentiated thyroid carcinoma: A hospital-based clinicopathological study and review of literature.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171
    Department of Otorhinolaryngology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
    Introduction: Poorly differentiated thyroid carcinoma (PDTC) is a rare aggressive malignancy of thyroid follicular cells and has unique features in morphology and behavior. This study was aimed to describe the experience of a tertiary medical center with PDTC within a 10-year period.

    Materials And Methods: This is a descriptive retrospective study of eight cases of PDTC among 418 various thyroid carcinomas. Read More

    The absence of CD56 expression can differentiate papillary thyroid carcinoma from other thyroid lesions.
    Indian J Pathol Microbiol 2017 Apr-Jun;60(2):161-166
    Department of Pathology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
    Context: The neural cell adhesion molecule CD56 is an antigen important for the differentiation of the follicular epithelium. Recent studies have reported low or absent expression of CD56 in papillary thyroid carcinoma (PTC) and its presence in normal thyroid tissue, benign thyroid lesions, and most follicular non-PTC tumors.

    Aim: We wish to estimate the value of CD56 in the differentiation of PTC (including follicular variant-PTC [FV-PTC]) from other nontumoral lesions and follicular thyroid neoplasias. Read More

    Insights into the management of papillary microcarcinoma of the thyroid.
    Thyroid 2017 Jun 19. Epub 2017 Jun 19.
    Kuma Hospital, Department of Surgery , Shimoyamate-dori, Chuo-ku, Kobe , Kobe, Japan , 6500011 ;
    Background: Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from thyroid carcinoma have been reported from many countries, and these increases are thought to be due mostly to the increased detection of small papillary thyroid carcinomas (PTCs), including papillary microcarcinomas (PMCs, i.e., PTCs ≤10 mm). Read More

    Influence of chronic lymphocytic thyroiditis on the risk of persistent and recurrent disease in patients with papillary thyroid carcinoma and elevated antithyroglobulin antibodies after initial therapy.
    Braz J Otorhinolaryngol 2017 Jun 2. Epub 2017 Jun 2.
    Santa Casa de Belo Horizonte, Serviço de Endocrinologia, Belo Horizonte, MG, Brazil.
    Introduction: In patients with papillary thyroid carcinoma who have negative serum thyroglobulin after initial therapy, the risk of structural disease is higher among those with elevated antithyroglobulin antibodies compared to patients without antithyroglobulin antibodies. Other studies suggest that the presence of chronic lymphocytic thyroiditis is associated with a lower risk of persistence/recurrence of papillary thyroid carcinoma.

    Objective: This prospective study evaluated the influence of chronic lymphocytic thyroiditis on the risk of persistence and recurrence of papillary thyroid carcinoma in patients with negative thyroglobulin but elevated antithyroglobulin antibodies after initial therapy. Read More

    The total number of prelaryngeal and pretracheal lymph node metastases: is it a reliable predictor of contralateral central lymph node metastasis in papillary thyroid carcinoma?
    J Surg Res 2017 Jun 3;214:162-167. Epub 2015 Mar 3.
    Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China. Electronic address:
    Background: Central lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC) is common and being able to predict CLN metastasis helps surgeons determine individualized therapy. However, the relationship between contralateral CLN metastasis and the total number of positive lymph nodes (LNs) in the combined prelaryngeal and pretracheal region remains unclear. This study aimed to investigate whether the total number of positive LNs in the combined prelaryngeal and pretracheal region has clinical significance as a predictor for contralateral CLN metastasis. Read More

    Correlation of thyroid stimulating hormone receptor mRNA expression levels in peripheral blood with undesirable clinicopathological features in papillary thyroid carcinoma patients.
    Oncotarget 2017 May 26. Epub 2017 May 26.
    Department of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China.
    To determine the extent to which thyroid stimulating hormone receptor (TSHR) mRNA in peripheral blood (PB) has diagnostic value for papillary thyroid carcinoma (PTC). We obtained pre- and postoperative PB samples from 104 thyroid disease patients and collected 11 healthy volunteers' PB samples twice apiece at different times. We used reverse transcription polymerase chain reaction (RT-PCR) to quantify TSHR mRNA expression levels in the samples. Read More

    Papillary thyroid carcinoma expressing CD20.
    Pathol Int 2017 Jun 15. Epub 2017 Jun 15.
    Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
    We identified a case of lymphadenopathy of metastatic papillary thyroid carcinoma (PTC) with CD20 expression, which was also expressed by the primary tumor. CD20 expression was identified using immunohistochemistry (IHC) in metastatic PTC biopsy samples from a 58-year-old woman. CD20 expression was initially determined using a CD20-recognizing L26 clone. Read More

    The Molecular Effect of Diagnostic Absorbed Doses from (131)I on Papillary Thyroid Cancer Cells In Vitro.
    Molecules 2017 Jun 15;22(6). Epub 2017 Jun 15.
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz; Poland.
    Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of a therapeutic dose of (131)I. Unfortunately, administration of the radioisotope in a diagnostic dose may decrease further radioiodine uptake-the phenomenon called "thyroid stunning". We estimated radiation absorbed dose-dependent changes in genetic material, in particular in the sodium iodide symporter (NIS) gene promoter, and the NIS protein level in a K1 cell line derived from the metastasis of a human papillary thyroid carcinoma exposed to (131)I in culture. Read More

    Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature.
    Clin Med Insights Endocrinol Diabetes 2017 6;10:1179551417712521. Epub 2017 Jun 6.
    Clínica de Endocrinología y Metabolismo, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
    Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. Read More

    TERT promoter mutations were not found in papillary thyroid microcarcinomas that showed disease progression on active surveillance.
    Thyroid 2017 Jun 14. Epub 2017 Jun 14.
    Kuma Hospital, Surgery , 8-2-35 Shimoyamate-dori, Chuo-ku, , Kobe, Japan , 650-0011.
    Background: Papillary thyroid carcinoma (PTC) generally has an indolent course, and non-operative management is acknowledged for papillary thyroid microcarcinoma (PTMC). However, some PTMCs progress and we cannot predict future progression at their presentation. BRAF and TERT promoter mutations were recently reported to be associated with poor outcomes of PTC. Read More

    Lymph node metastasis characteristics of papillary thyroid carcinoma located in the isthmus: A single-center analysis.
    Medicine (Baltimore) 2017 Jun;96(24):e7143
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China.
    The frequency and pattern of lymph node metastasis and the extent of dissection for isthmic papillary thyroid carcinoma (PTC) remain unclear, and the aim of this present study was to evaluate these characteristics and to attempt to detect the best surgical protocol for isthmic PTCs. A total of 3185 consecutive patients with PTCs were reviewed. Of these patients, 47 with a single isthmic PTC were enrolled in our study, and matched 47 patients with a single PTC located in the unilateral lobe were randomly selected and added for comparison of their baseline tumor characteristics and lymph node metastasis characteristics. Read More

    Value of 99mTc-MIBI SPECT/CT parathyroid imaging and ultrasonography for concomitant thyroid carcinoma.
    Nucl Med Commun 2017 Jun 13. Epub 2017 Jun 13.
    Departments of aNuclear Medicine bEndocrine and Metabolic Diseases, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Purpose: We aimed to assess the frequency of carcinoma in cases with suspected parathyroid adenoma and test the value of Tc-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) parathyroid imaging and neck ultrasonography in detecting concomitant thyroid carcinoma.

    Patients And Methods: We enrolled 741 patients with clinically suspected parathyroid adenoma who underwent Tc-MIBI planer scans and SPECT/CT of the skull base, neck, and thorax; patients also underwent ultrasonography within 1 month before SPECT/CT. Each case with suspected lesion was analyzed and correlated with pathology. Read More

    [Molecular Aspects of Thyroid Tumors with Emphasis on MicroRNA and Their Clinical Implications].
    Klin Onkol 2017 ;30(3):167-174
    Background: Central to neoplastic transformation and tumor progression is alteration of the signaling pathways that control cell proliferation and apoptosis. The key mechanisms for this neoplastic process are genetic changes (mutations of cancer-related genes) and recently identified epigenetic changes that involve DNA methylation, chromatin remodeling (which has a profound effect on the control of gene expression), and noncoding, regulatory RNA (notably, microRNA - miRNA). MiRNAs control expression of their target gene post-transcriptionally. Read More

    Surgical approach to level VI in papillary thyroid carcinoma: an overview.
    Updates Surg 2017 Jun 13. Epub 2017 Jun 13.
    Istituto di Semeiotica Chirurgica, U.O. Chirurgia Endocrina e Metabolica, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, L.go A. Gemelli 8, 00168, Rome, Italy.
    One of the most controversial issues in the treatment of thyroid cancer is the management of the central neck nodes in patients with papillary thyroid carcinoma (PTC). Lymph node involvement is common in patients with PTC and it may negatively affect recurrence rate and, probably, survival. Although therapeutic compartment-oriented central neck dissection is the standard treatment for patients with clinical nodal involvement (cN1) PTC, the role and the extension for elective or prophylactic central neck dissection (PCND) in patients with clinically node negative (cN0) neoplasms remains controversial. Read More

    Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014.
    Eur Thyroid J 2017 Feb 9;6(1):40-46. Epub 2016 Nov 9.
    Clinic of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Background: Thyroid cancer (TC) is a rare condition in children. It may be associated with radiation, iodine deficiency or familial inheritance.

    Aims: The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania. Read More

    Patients with Multifocal Macroscopic Papillary Thyroid Carcinoma Have a Low Risk of Recurrence at Early Follow-Up after Total Thyroidectomy and Radioactive Iodine Treatment.
    Eur Thyroid J 2017 Feb 4;6(1):31-39. Epub 2016 Oct 4.
    Department of Pathology, Endocrinology Service, Department of Medicine, N.Y., USA.
    Background: Multifocal thyroid cancer involvement is a common presentation in papillary thyroid cancer. The risk of recurrence of intrathyroidal multifocal papillary microcarcinoma (<1 cm) is documented to be low. However, the risk of recurrence of multifocal macroscopic thyroid cancer is not known. Read More

    Financial Implication of Radioactive Iodine Therapy for Early-Stage Papillary Thyroid Cancer.
    Oncology 2017 Jun 14;93(2). Epub 2017 Jun 14.
    Objective: The aim of this study was to evaluate disease-specific survival and cost related to radioactive iodine therapy (RAI) utilization in patients with early-stage papillary thyroid carcinoma (PTC).

    Methods: This was a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database, 2004-2012.

    Results: A total of 38,374 patients with PTC were identified. Read More

    Triage of the indeterminate thyroid aspirate: What are the options for the practicing cytopathologist?
    Cancer 2017 Jun;125(S6):477-485
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
    Fine-needle aspiration (FNA) plays a key role in the early evaluation of patients with thyroid nodules; however, from 15% to 30% of FNA specimens are cytologically indeterminate. Molecular testing has proven useful when applied to indeterminate thyroid FNAs, and its use has been endorsed in the American Thyroid Association guidelines. In addition to the noncommercial ("in-house") application of v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), rat sarcoma (RAS), rearranged in transformation/papillary thyroid carcinoma (RET/PTC), and peroxisome proliferator-activated receptor γ/paired box gene 8 (PPARγ/PAX8) testing, there are currently 3 commercially available molecular panels that vary in their relative reported performances, strengths, and limitations. Read More

    Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma.
    J Surg Oncol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Background And Objectives: Stratification of extranodal extension (ENE) extent has the potential to improve the accuracy of risk estimations in papillary thyroid carcinoma (PTC). This study examined the prognostic importance of nodal factors, including ENE, in PTC patients.

    Methods: This study enrolled 2071 consecutive patients with treatment-naïve PTC who underwent thyroidectomy between 2006 and 2010. Read More

    Increased incidence of thyroid cancer in Navarra (Spain). Evolution and clinical characteristics, 1986-2010.
    Endocrinol Diabetes Nutr 2017 Jun - Jul;64(6):303-309. Epub 2017 May 11.
    Servicio de Endocrinología, Complejo Hospitalario de Navarra, IdiSNA, Navarra Institute for Health Research, Pamplona, España. Electronic address:
    Introduction: The latest published studies show an increased incidence of thyroid cancer worldwide. The aim of this study was to analyze the changes in the incidence of thyroid cancer in Navarra and its clinical presentation regarding sex, histological subtype and size over the last 25 years.

    Methods: Thyroid cancer incidence rates were calculated on the basis of data from the Cancer Registry of Navarra during 1986-2010. Read More

    Multi-modality surgical treatment for an increasingly common patient with morbid obesity and papillary thyroid carcinoma.
    J Surg Case Rep 2017 Jun 6;2017(6):rjw200. Epub 2017 Jun 6.
    Department of Minimally Invasive and Bariatric Surgery, Stanford University Hospitals and Clinics, Stanford, CA, USA.
    The link between obesity and health disorders such as hypertension, diabetes and coronary artery disease is well known. When a morbidly obese patient presents with a new diagnosis of any cancer, it adds to the many challenges both the patient and treating physicians face. Not only is surgical resection of the malignancy more technically challenging, but also postoperative care such as therapeutic radiation and follow-up imaging is limited by the weight and size restrictions of the machines. Read More

    Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with squamous differentiation: A novel histological finding.
    Hum Pathol 2017 Jun 7. Epub 2017 Jun 7.
    Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo 276-8524, Japan.
    Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm originating from the nasopharyngeal surface epithelium. Histopathologically, TL-LGNPPA is characterized by cuboidal/columnar tumor cells forming papillary fronds and thyroid transcription factor-1 (TTF-1) expression resembling papillary thyroid carcinoma. To date, the recorded histological features of TL-LGNPPA have been almost uniform, and the range of histological variations in this tumor type has not been sufficiently understood. Read More

    Papillary thyroid carcinoma metastasizing to anaplastic meningioma: an unusual case of tumor-to-tumor metastasis.
    Brain Tumor Pathol 2017 Jun 9. Epub 2017 Jun 9.
    Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada.
    Tumor-to-tumor metastasis is a relatively uncommon entity, whereby the so-called 'recipient' tumor is involved by another biologically unrelated 'donor' tumor. Intracranially, meningioma (WHO grade 1) is the most common recipient tumor, while breast and lung cancers are the most common donor tumors. We present an unusual case of intracranial tumor-to-tumor metastasis involving papillary thyroid carcinoma (PTC) believed to have metastasized to an anaplastic meningioma (WHO grade 3). Read More

    Long-term outcomes of central neck dissection for cN0 papillary thyroid carcinoma.
    Am J Otolaryngol 2017 Jun 7. Epub 2017 Jun 7.
    Otolaryngology Unit, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy.
    Objective: The risk-benefit ratio of central neck dissection (CND) in patients affected by papillary thyroid carcinoma (PTC) without clinical or ultrasonographic (US) evidence of neck lymph node metastasis (cN0) is currently debated. The aim of this study was to evaluate long-term outcome of CND on locoregional recurrence, distant metastasis, survival, and postoperative complications in a large series of patients with cN0-PTC.

    Study Design: Observational retrospective controlled study. Read More

    Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma.
    Oncol Lett 2017 Jun 11;13(6):4252-4266. Epub 2017 Apr 11.
    Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
    Circulating microRNAs (miRNAs/miRs) are considered to be potential biomarkers for numerous types of cancer. However, previous investigations into the expression of miRNAs in the serum of patients with papillary thyroid carcinoma (PTC) to predict diagnosis, prognosis and recurrence have reported conflicting results, and the role of miRNAs remains unclear. The present study dynamically assessed the circulating miRNA profile in patients with PTC and determined whether miRNAs in the serum could be used as biomarkers for the diagnosis, prognosis and recurrence of PTC. Read More

    Consumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
    J Nutr 2017 Jun 7. Epub 2017 Jun 7.
    International Agency for Research on Cancer, Lyon, France.
    Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Read More

    Papillary Thyroid Carcinoma: Analysis of the Central Compartment's Lymph Nodes Metastases.
    Acta Medica (Hradec Kralove) 2017 ;60(1):44-50
    Department of Medical Biochemistry JFM CU, Slovakia.
    Background: Papillary thyroid carcinoma is typical by regional lymph nodes metastases. Therefore we decided to analyse associated risk factors.

    Objective: In this retrospective study we focused on the incidence of metastatic involvement of the central compartment's lymph nodes correlated with age, size of the primary tumour, infiltration of thyroid gland capsule, positive lymphangioinvasion in order to assess risk factors. Read More

    Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features.
    J Endocrinol Invest 2017 Jun 6. Epub 2017 Jun 6.
    Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, 2 Al Simeonidi Str, 54007, Thessaloniki, Greece.
    Purpose: Vitamin D receptor (VDR) and progesterone receptor (PR) expression has been described in papillary thyroid carcinoma (PTC) but data regarding association with tumor histological characteristics and localization of the protein expression are scarce.

    Materials And Methods: Formalin-fixed, paraffin-embedded specimens from 45 patients with PTC (cases) were retrieved and tumor histological data were recorded. We analyzed gene and protein expression of VDR and PR and gene expression of vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzymes in follicular cancer cells and the adjacent non-neoplastic thyroid tissue (NNTT). Read More

    Lymph Node Metastases in Papillary and Medullary Thyroid Carcinoma Are Independent of Intratumoral Lymphatic Vessel Density.
    Eur Thyroid J 2017 Apr 17;6(2):57-64. Epub 2017 Mar 17.
    Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
    Background: Blood and lymph vessel invasion are well-recognized markers of tumor aggressiveness, as these are the routes that lead to metastases. Thyroid tumors, depending on the histological variant, tend to have distinctive biological behaviors and use different vascular routes to metastasize, yet the mechanisms underlying the metastatic process are still poorly understood.

    Objectives: The aim of this study was to assess how the lymph vessel density (LVD) in different histological types of thyroid tumors, and in their surrounding tissue, correlate with the presence of lymph node metastases (LNM) and tumor pathological features. Read More

    Renal metastases as the initial presentation of papillary thyroid carcinoma: A case report and literature review.
    Mol Clin Oncol 2017 Jun 8;6(6):821-824. Epub 2017 May 8.
    Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
    Distant metastasis of thyroid carcinoma is rare, and it occurs particularly rarely in renal regions, which represent ~3% of all thyroid distant metastases, with fewer than 30 single case study reports existing in the literature. The present study (and subsequent literature review) of papillary thyroid carcinoma (PTC) reports the case of a 53-year-old male patient who presented with a left renal mass and who had no previous history of thyroid disease. Following renal and thyroid surgery, postoperative pathology confirmed the case to be a follicular variant of PTC, accompanied by renal metastasis. Read More

    A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter.
    BMC Clin Pathol 2017 2;17. Epub 2017 Jun 2.
    Department of Pathology, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka City, Osaka, 543-0035 Japan.
    Background: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare.

    Case Presentation: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Read More

    Diagnostic Performance of (18)F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative (131)I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level.
    Sci Rep 2017 Jun 6;7(1):2849. Epub 2017 Jun 6.
    Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
    Differentiated thyroid cancer (DTC) patients with negative serum thyroglobulin (Tg), negative (131)I whole-body scintigraphy ((131)I-WBS) at first post-ablation and progressively increased TgAb level are a relatively rare entity in the follow-up after total thyroidectomy and radioactive iodine therapy. The value of (18)F-FDG PET/CT in detecting the recurrence of disease in these patients has only been reported in a small case series. The goal of this study was to investigate the diagnostic accuracy of (18)F-FDG PET/CT in detecting recurrent disease in these specific PTC patients and to identify risk factors for patients with positive (18)F-FDG PET/CT results. Read More

    Disease Progression in Papillary Thyroid Cancer with Biochemical Incomplete Response to Initial Therapy.
    Ann Surg Oncol 2017 Jun 5. Epub 2017 Jun 5.
    Endocrine Surgical Unit, University of Sydney, Sydney, NSW, Australia.
    Background: Dynamic risk stratification is utilized in the follow-up of patients with papillary thyroid carcinoma (PTC). Analysis of outcomes after biochemical incomplete response (BIR) to initial therapy will allow better individualization of care.

    Methods: A total of 494 patients with PTC were followed prospectively. Read More

    Benign and Malignant Thyroid Gland Diseases in the Patients with Primary Hyperparathyroidism.
    Int J Appl Basic Med Res 2017 Apr-Jun;7(2):117-120
    Department of Endocrinology and Metabolism, Medical Faculty, Trakya University, Edirne, Turkey.
    Introduction: This study aimed to evaluate concurrently detected thyroid pathologies in the patients who underwent surgery for primary hyperparathyroidism (PHPT).

    Materials And Methods: In this study, we retrospectively analyzed the files of the patients who underwent surgery for PHPT between 2012 and 2015. Pre- and post-operative laboratory examination results and preoperative radiological and nuclear medicine findings of the patients were retrospectively recorded. Read More

    1 OF 317