22,866 results match your criteria Thyroid Papillary Carcinoma


Clinical implication of xenotropic and polytropic retrovirus receptor 1 in papillary thyroid carcinoma.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):90-96

Department of Thyroid Surgery,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.

To investigate the expression of xenotropic and polytropic retrovirus receptor 1 () in papillary thyroid cancer (PTC) and its clinical implication. The HPA and UALCAN databases were used to explore the expression of XPR1 in PTC and normal tissues. The cBioPortal database was used to obtain the clinical data of PTC patients and gene expression profile. Read More

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February 2021

Clinicopathological Significance of Papillary Thyroid Carcinoma Located in the Isthmus: A Meta-Analysis.

World J Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Endocrinology and Metabolism, Chosun University Hospital, Chosun University School of Medicine, 588 Seoseok-Dong, Dong-Gu, Gwangju, Republic of Korea.

Background: The thyroid isthmus is located directly anterior to the trachea and is covered by the strap muscles. Several studies have suggested that papillary thyroid carcinoma (PTC) in the isthmus is more aggressive and is associated with a poor prognosis. The purpose of this meta-analysis was to assess the clinicopathological characteristics and recurrence rates of PTC in the isthmus compared to PTC at other sites. Read More

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Papillary thyroid microcarcinoma with lung metastases: a case report and review of the literature.

Thyroid Res 2021 Jun 11;14(1):15. Epub 2021 Jun 11.

Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Distant metastasis from papillary thyroid microcarcinoma (PTMC) is rare. Here we report a case of PTMC with multiple lung metastases.

Case Presentation: A 64-year-old man presented to our hospital with abdominal pain. Read More

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Integrated bioinformatics analysis and screening of hub genes in papillary thyroid carcinoma.

PLoS One 2021 11;16(6):e0251962. Epub 2021 Jun 11.

Department of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, PR China.

Background: With the increasing incidence of papillary thyroid carcinoma (PTC), PTC continues to garner attention worldwide; however its pathogenesis remains to be elucidated. The purpose of this study was to explore key biomarkers and potential new therapeutic targets for, PTC.

Methods: GEO2R and Venn online software were used for screening of differentially expressed genes. Read More

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miR-622 Suppresses Tumor Formation by Directly Targeting VEGFA in Papillary Thyroid Carcinoma [Retraction].

Authors:

Onco Targets Ther 2021 3;14:3597. Epub 2021 Jun 3.

[This retracts the article DOI: 10.2147/OTT.S156810. Read More

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Postoperatively determined high-risk histopathologic features in papillary thyroid carcinoma initially eligible for thyroid lobectomy: a game changer.

Endocrine 2021 Jun 10. Epub 2021 Jun 10.

Department of Surgical, Medical, Pathology, and Critical Care, The University of Pisa, Pisa, 56124, Italy.

Purpose: Recent clinical practice guidelines consider thyroid lobectomy a viable alternative for low-risk papillary thyroid carcinoma PTC measuring 1-4 cm in size. We aimed to assess the likelihood of finding postoperatively determined high-risk histopathologic features that would lead to the recommendation of completion thyroidectomy.

Methods: A retrospective review of patients who underwent total thyroidectomy for PTC measuring 1-4 cm in size between Jan 2012 and Jan 2018 was conducted. Read More

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circRPS28 (hsa_circ_0049055) is a novel contributor for papillary thyroid carcinoma by regulating cell growth and motility via functioning as ceRNA for miR-345-5p to regulate frizzled family receptor 8 (FZD8).

Endocr J 2021 Jun 10. Epub 2021 Jun 10.

Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China.

Circular RNA 40S ribosomal protein S28 (circRPS28; hsa_circ_0049055) is upregulated in papillary thyroid carcinoma (PTC) patients. However, its role remained uncovered in the progression of PTC. Above all, expression of circRPS28 was determined in PTC samples by real-time quantitative PCR and circRPS28 was highly expressed in tumor tissues and cells. Read More

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Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study.

Endocrinol Metab (Seoul) 2021 Jun 10. Epub 2021 Jun 10.

Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Background: We aimed to evaluate the clinicopathological features and biological behaviors of Korean thyroid cancer patients with rare variants of papillary thyroid carcinoma (PTC) to address the ambiguity regarding the prognostic consequences of these variants.

Methods: We retrospectively reviewed the medical records of 5,496 patients who underwent thyroid surgery for PTC, between January and December 2012, in nine tertiary hospitals. Rare PTC variants included tall cell (TCV), columnar cell (CCV), diffuse sclerosing (DSV), cribriform-morular (CMV), solid (SV), hobnail, and Warthin-like variants. Read More

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A unique case of splenic tumor exhibiting a serous carcinoma phenotype.

SAGE Open Med Case Rep 2021 24;9:2050313X211016992. Epub 2021 May 24.

Departments of Pathology and Translational Research, Graduate School of Medicine, Gifu University, Gifu, Japan.

The spleen has no epithelial element; thus, primary carcinoma of the spleen is quite rare. We present the case of a patient with serous carcinoma of the spleen. A 76-year-old woman with no significant medical history presented with a huge lesion in the spleen. Read More

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Risk factors for recurrence of follicular thyroid cancer: A systematic review.

Thyroid 2021 Jun 9. Epub 2021 Jun 9.

Rigshospitalet HovedOrtoCentret, 545086, Department of Otorhinolaryngology, Head and Neck Surgery, And Audiology, Kobenhavn, Denmark;

Background: In risk assessment of recurrence, papillary (PTC) and follicular thyroid cancer (FTC) are often grouped together as differentiated thyroid cancer (DTC). However, while risk factors affecting recurrence of PTC are well established, risk factors for recurrence of FTC are not. This systematic review examines risk factors for recurrence of FTC and evaluates their significance. Read More

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[Analysis of correlation factors of contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma with lateral cervical lymph node metastasis].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):502-506

Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

To examine the correlation factors of contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma with lateral cervical lymph node metastasis. The clinical data of patients with unilateral papillary thyroid carcinoma who underwent total thyroidectomy and bilateral central lymph node dissection and ipsilateral cervical lymph node dissection from June 2016 to June 2018 at Department of Thyroid Surgery, West China Hospital, Sichuan University were analyzed retrospectively. A total of 317 patients, including 87 males and 230 females, aged (41. Read More

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Diagnostic and prognostic impact of Cytokeratin 19 expression analysis in human tumors: A tissue microarray study of 13,172 tumors.

Hum Pathol 2021 Jun 5. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

To evaluate cytokeratin 19 expression in normal and cancerous tissues, 15,977 samples from 122 tumor types and 608 samples of 76 normal tissue types were analyzed by immunohistochemistry. In normal tissues, CK19 expression occurred in epithelial cells of most glandular organs but was strictly limited to the basal cell layer of non-keratinizing squamous epithelium and absent in the skin. CK19 expression in ≥90% of cases was seen in 34% of the tumor entities including the adenocarcinomas of the pancreas (99. Read More

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Overexpression of serum lncRNA-ABHD11-AS1 as poor prognosis of patients with papillary thyroid carcinoma.

Exp Mol Pathol 2021 Jun 6;121:104658. Epub 2021 Jun 6.

Nuclear Medicine Department, The First Hospital of Jilin University, Changchun City 130000, Jilin Province, China. Electronic address:

This paper was aimed at exploring the correlation of long non-coding RNA (lncRNA)-ABHD11 Antisense RNA1 (ABHD11-AS1) with the poor prognosis of patients with papillary thyroid carcinoma (PTC) and at investigating its effects on the survival of PTC cells. Serum was respectively collected from 64 PTC patients who were admitted to our hospital (PTC group) and from 50 healthy controls who underwent physical examinations (HC group) both from April 2011 to April 2015. The expression levels of ABHD11-AS1 in the serum were detected, and the values of it for diagnosis and prognosis (5-year follow-ups) were analyzed. Read More

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Silencing of cystatin SN (CST1) abrogates cancer progression and stem cell properties in papillary thyroid carcinoma (PTC).

FEBS Open Bio 2021 Jun 8. Epub 2021 Jun 8.

Department of Ultrasound, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Liyushan South Road No.137, Urumqi, 830054, People's Republic of China.

Papillary thyroid carcinoma (PTC) accounts for approximately 80% of total thyroid cancer worldwide. Although the prognosis for early-stage PTC is favorable, the 5-year survival rate of patients with late-stage PTC is still very poor. Cystatin SN (cystatin 1, CST1) facilitates the progression of multiple cancers, but its role in regulating papillary thyroid carcinoma (PTC) pathogenesis is still largely unknown. Read More

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Thyroglossal Duct Cyst Papillary Carcinoma With Airway Compromise.

Ear Nose Throat J 2021 Jun 8:1455613211022077. Epub 2021 Jun 8.

Department of Otolaryngology-Head and Neck Surgery, 36897Mackay Memorial Hospital, Taipei.

Thyroglossal duct cysts are typically benign and usually asymptomatic. Malignant transformation is uncommon. Intralaryngeal extension is rare and results in dysphonia or dyspnea. Read More

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Multifocality and Progression of Papillary Thyroid Microcarcinoma During Active Surveillance.

World J Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Endocrine Surgery, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Background: Prospective trials of active surveillance (AS) have shown low rates of progression in low-risk papillary thyroid microcarcinoma (PTMC; T1aN0M0). However, the significance of multifocality as a prognostic factor remains controversial.

Methods: Data from 571 patients (mean age, 53. Read More

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A 44-Year-Old Woman With Multiple Neoplasms and Cystic Lung Disease.

Chest 2021 Jun;159(6):e381-e384

Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL.

Case Presentation: A 44-year-old woman with a history of renal cell carcinoma and thyroid cancer was referred to our institution for evaluation of cystic lung disease. She was an active smoker with a 15-pack-year of tobacco use. Two years before her presentation, she underwent a left nephrectomy for renal cell carcinoma, clear cell type. Read More

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Reproductive and menstrual factors for papillary thyroid cancer risk: A case-control study in Chinese women.

Cancer Epidemiol 2021 Jun 4;73:101964. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China. Electronic address:

Background: Thyroid cancer (TC) is threefold more common in women than men. Reproductive and menstrual factors may be related to the onset of papillary thyroid cancer (PTC). This study aims to determine the association of reproductive and menstrual factors with PTC in Chinese females. Read More

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Well-Differentiated Thyroid Cancer Invading the Trachea in a Pediatric Patient.

AACE Clin Case Rep 2021 May-Jun;7(3):207-210. Epub 2021 Mar 23.

University of Michigan, Department of Otolaryngology-Head and Neck Surgery, Ann Arbor, Michigan.

Objectives: Pediatric thyroid cancer is rare. Most cases are well-differentiated thyroid cancers (WDTCs). However, gross laryngotracheal invasion of WDTCs is unusual. Read More

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Increased Thyroid-Hormone Requirements Consistent With Type 3 Deiodinase Induction Related to Ibrutinib in a Thyroidectomized Woman.

AACE Clin Case Rep 2021 Mar-Apr;7(2):121-123. Epub 2020 Dec 28.

Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective: Tyrosine-kinase inhibitors (TKIs) are chemotherapeutic agents associated with increased thyroid-hormone requirements and altered deiodinase activity. We present the first case to link these findings to the TKI ibrutinib.

Methods: Serial thyroid-stimulating hormone (TSH), free-thyroxine (FT4), free-triiodothyronine (FT3), and reverse-triiodothyronine (rT3) levels were assessed. Read More

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December 2020

Predictive Factor of Large-Volume Central Lymph Node Metastasis in Clinical N0 Papillary Thyroid Carcinoma Patients Underwent Total Thyroidectomy.

Front Oncol 2021 19;11:574774. Epub 2021 May 19.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Large-volume central lymph node metastasis (large-volume CLNM) is associated with high recurrence rate in papillary thyroid carcinoma (PTC) patients. However, sensitivity in investigating large-volume CLNM on preoperative ultrasonography (US) is not high. The aim of this study is to investigate the clinical factors associated with large-volume CLNM in clinical N0 PTC patients. Read More

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Cytological and molecular diagnosis of Hürthle cell thyroid tumors: Analysis of three cases.

Mol Clin Oncol 2021 Jul 28;15(1):149. Epub 2021 May 28.

Department of Surgery, Novosibirsk State Medical University, Novosibirsk 630091, Russia.

The cytological diagnosis of Hürthle cell (oncocytic) thyroid tumors by means of fine-needle aspiration biopsy represents a challenge, as Hürthle cell polymorphism and atypia alone are not indications of malignancy. In our recent work, an original diagnostic algorithm was proposed, which identified and typed malignant thyroid tumors by analyzing the molecular markers of cytological preparations. The aim of the present study was to assess the effectiveness of this algorithm at detecting Hürthle cell thyroid tumors in clinical samples used for cytological examination. Read More

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Change of Therapeutic Response Classification According to Recombinant Human Thyrotropin-Stimulated Thyroglobulin Measured at Different Time Points in Papillary Thyroid Carcinoma.

Nucl Med Mol Imaging 2021 Jun 29;55(3):116-122. Epub 2021 Apr 29.

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun-gun, Jeollanam-do 58128 Republic of Korea.

Purpose: We investigated whether response classification after total thyroidectomy and radioactive iodine (RAI) therapy could be affected by serum levels of recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin (Tg) measured at different time points in a follow-up of patients with papillary thyroid carcinoma (PTC).

Methods: A total of 147 PTC patients underwent serum Tg measurement for response assessment 6 to 24 months after the first RAI therapy. Serum Tg levels were measured at 24 h (D1Tg) and 48-72 h (D2-3Tg) after the 2 injection of rhTSH. Read More

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ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma.

J Cancer 2021 13;12(13):3997-4010. Epub 2021 May 13.

Zhangjiakou Key Laboratory of Thyroid Cancer Precision Diagnosis, Hebei North University, Zhangjiakou, 075000, China.

Adenosine A1 Receptor (ADORA1) is an adenosine receptor particularly relevant to the immunomodulatory process of malignant tumors. There are growing evidences that dysregulated overexpression of ADORA1 can promote many types of tumorigenesis. However, the expression and prognostic value and mechanism of ADORA1 in thyroid papillary carcinoma have not been reported. Read More

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Clinical value of color Doppler ultrasound combined with serum tumor markers for the diagnosis of medullary thyroid carcinoma.

Oncol Lett 2021 Jul 27;22(1):561. Epub 2021 May 27.

Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

The present study aimed to explore the clinical value of color Doppler ultrasound combined with serum tumor markers, including calcitonin (CT) and carcinoembryonic antigen (CEA), for the diagnosis of medullary thyroid carcinoma (MTC). A total of 39 patients with MTC (MTC group), 50 patients with papillary thyroid carcinoma (PTC) (PTC group) and 30 patients with thyroid adenoma (benign control group) were enrolled in the present study. The patients were hospitalized at the Affiliated Hospital of Qingdao University from January 2012 to December 2018 and were diagnosed through surgical procedures and pathology laboratory results. Read More

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A Preliminary Study of Quantitative Ultrasound for Cancer-Risk Assessment of Thyroid Nodules.

Front Endocrinol (Lausanne) 2021 19;12:627698. Epub 2021 May 19.

Section of Endocrinology, Diabetes and Nutrition, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States.

Background: Gray-scale, B-mode ultrasound (US) imaging is part of the standard clinical procedure for evaluating thyroid nodules (TNs). It is limited by its instrument- and operator-dependence and inter-observer variability. In addition, the accepted high-risk B-mode US TN features are more specific for detecting classic papillary thyroid cancer rather than the follicular variant of papillary thyroid cancer or follicular thyroid cancer. Read More

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Feasibility study of using virtual non-contrast images derived from dual-energy CT to replace true non-contrast images in patients diagnosed with papillary thyroid carcinoma.

J Xray Sci Technol 2021 Jun 3. Epub 2021 Jun 3.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: To assess the feasibility of using virtual non-contrast (VNC) images derived from dual-energy computed tomography (DECT) to replace true non-contrast (TNC) images of papillary thyroid carcinoma (PTC) patients.

Methods: Images of 96 PTC patients were retrospectively analyzed. TNC images were acquired under the single-energy mode of DECT after the plain scanning. Read More

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Thyroid Cancer Detected on 68Ga-PMSA PET/CT.

J Pak Med Assoc 2021 May;71(5):1511-1512

Jack Brignall PET-CT Centre, Castle Hill Hospital, Cottingham.

Ga-68 PSMA is a promising radiotracer for both staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the endothelium of tumour-associated neo vasculature of various solid malignancies possibly due to tumour-associated angiogenic factors and endothelial cell sprouting. We report a case of 72-yearold male with known prostate cancer on follow-up with mild increase in serum PSA level. Read More

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E-Cadherin expression in human tumors: a tissue microarray study on 10,851 tumors.

Biomark Res 2021 Jun 5;9(1):44. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Background: The E-Cadherin gene (CDH1, Cadherin 1), located at 16q22.1 encodes for a calcium-dependent membranous glycoprotein with an important role in cellular adhesion and polarity maintenance.

Methods: To systematically determine E-Cadherin protein expression in normal and cancerous tissues, 14,637 tumor samples from 112 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types were analyzed by immunohistochemistry in a tissue microarray format. Read More

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The first competing risk survival nomogram in patients with papillary renal cell carcinoma.

Sci Rep 2021 Jun 4;11(1):11835. Epub 2021 Jun 4.

Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of cancer-specific mortality (CSM) and other-cause mortality (OCM) of pRCC over time, and constructed a nomogram predicting the probability of 2-, 3- and 5-year CSM based on competing risk regression. A total of 5993 pRCC patients who underwent nephrectomy between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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