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    16136 results match your criteria Thyroid Papillary Carcinoma

    1 OF 323

    CXXC5 expression in prostate cancer: implications for cancer progression.
    Int J Exp Pathol 2017 Aug;98(4):234-243
    School of Medicine, University of Cartagena, Cartagena, Colombia.
    Identification of genes specifically deregulated in prostate adenocarcinoma may lead to discovery of new oncogenes/tumour suppressors with clinical relevance for diagnosis, prognosis and/or therapy. CXXC5 is a gene encoding a retinoid-inducible nuclear factor, whose overexpression in breast tumours, metastatic malignant melanomas and papillary thyroid carcinoma has been recently reported. We previously found differential expression of CXXC5 transcripts in metastatic prostate cancer cell lines of both rat and human origin. Read More

    (18)F-fluorodeoxyglycose-avid thyroid incidentalomas: the importance of contextual interpretation.
    J Nucl Med 2017 Oct 12. Epub 2017 Oct 12.
    Peter MacCallum Cancer Centre, Australia.
    Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). Read More

    Roles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2.
    Tumour Biol 2017 Oct;39(10):1010428317719274
    1 Department of Thyroid Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
    The incidence of thyroid cancer has increased significantly in the last decade, and the most frequent type of this cancer is papillary thyroid carcinoma. MicroRNAs have been demonstrated to be abnormally expressed in tumors and associated with the development of the tumors. Our aim was to analyze the role and molecular mechanisms of tumor suppressor let-7b in the papillary thyroid carcinoma. Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features in the pediatric age group.
    Cancer 2017 Oct 12. Epub 2017 Oct 12.
    Department of Pathology, Loyola University School of Medicine, Maywood, Illinois.
    Background: The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) to replace the noninvasive follicular variant of PTC. The objective of the current study was to evaluate previously diagnosed PTC in the pediatric population, reappraise it for NIFTP, and discuss the impact of NIFTP on the risk of malignancy (ROM) for each The Bethesda System for Reporting Thyroid Cytopathology category in the pediatric population. Read More

    Intrathyroidal carotid artery and nonrecurring right recurrent laryngeal nerve: A case report.
    Head Neck 2017 Oct 11. Epub 2017 Oct 11.
    Department of Surgery, Division of Otolaryngology - Head and Neck Surgery The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania.
    Background: When performing thyroidectomy, knowledge of normal anatomy and variants is vital to avoid injuring nearby structures. Typically, the bilateral carotids course posterolateral to the thyroid gland. We describe a rare variant of an intrathyroidal carotid artery, not previously described in the literature. Read More

    Large (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
    PLoS One 2017 12;12(10):e0186242. Epub 2017 Oct 12.
    Department of Pathology, Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea.
    Background: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology.

    Methods: 632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included. Read More

    Assessment of Risk Factors in Metastatic / Recurrent Tall Cell Variant of Papillary Thyroid Carcinoma.
    Endokrynol Pol 2017 Oct 12. Epub 2017 Oct 12.
    Gulhane Training and Research Hospital, Department of Nuclear Medicine, Etlik, Ankara, TURKEY.
    Introduction: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor. A great majority of the cases live a disease-free life with quite favorable prognosis. There are lots of variants of PTC and a few of them exhibit aggressive behaviour. Read More

    Pathologic reporting of Tall Cell Variant of Papillary Thyroid Cancer: Have we reached a consensus?
    Thyroid 2017 Oct 12. Epub 2017 Oct 12.
    H. Lee Moffitt Cancer Center and Research Institute, Anatomic Pathology, Tampa, Florida, United States ;
    Background: Tall cell variant (TCV) is widely believed to be a more aggressive subtype of papillary thyroid carcinoma (PTC). Despite the significance of TCV with respect to risk stratification and therapeutic decision making, its diagnosis is subject to interobserver variability. We aim to determine the level of agreement among expert pathologists in the identification and reporting of TCV. Read More

    Hobnail Variant of Papillary Thyroid Carcinoma: a Literature Review.
    Endocr Pathol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology "M. Malpighi" at Bellaria Hospital, University of Bologna, Via Altura No. 3, 40126, Bologna, Italy.
    Papillary thyroid carcinoma is the most common thyroid malignancy and it is usually associated with a good prognosis. However, recurrence, metastases, and cancer death may occur in 10 to 15% of patients with more aggressive types of papillary thyroid carcinoma, such as tall cell, columnar cell, solid variant, or the more recently described hobnail variant of papillary thyroid carcinoma. Papillary thyroid carcinoma with a prominent hobnail pattern is a moderately differentiated papillary thyroid carcinoma variant with aggressive clinical behavior and significant mortality. Read More

    Gastrointestinal perforation related to lenvatinib, an anti-angiogenic inhibitor that targets multiple receptor tyrosine kinases, in a patient with metastatic thyroid cancer.
    Invest New Drugs 2017 Oct 11. Epub 2017 Oct 11.
    Department of Medical Oncology, Kishiwada City Hospital, 1001 Gakuhara, Kishiwada, Osaka, 596-8501, Japan.
    Lenvatinib, a novel potent multikinase inhibitor, was approved for the treatment of radioiodine-refractory differentiated thyroid cancer based on results from phase III trial (SELECT study). Thyroid cancer is a diverse disease that includes anaplastic thyroid cancer (ATC), which the most aggressive form of the disease, although it accounts for <2% of all thyroid cancers. Current treatments for ATC have limited efficacy. Read More

    Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma.
    J Pathol Transl Med 2017 Oct 3. Epub 2017 Oct 3.
    Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
    Background: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis. Read More

    Level V metastasis, a novel predicative factor for recurrence in N1b papillary thyroid carcinoma.
    Curr Pharm Des 2017 Oct 9. Epub 2017 Oct 9.
    Department of Thyroid Surgery, Ningbo NO.2 hospital. - Department of Thyroid Surgery, Ningbo NO.2 hospital. Ningbo, Zhejiang. China.
    Background: Lymph nodal (LN) metastasis classified as pN1b is considered as an independent poor prognostic factor for Papillary thyroid carcinoma (PTC) patients. However, whether LN metastasis can serve as a predictive factor for recurrence or disease-free survival of N1b PTC is still plagued by controversy.

    Methods: The N1b PTC patients who underwent total thyroidectomy and unilateral modified radical neck dissection (MRND) by the same surgical team in Ningbo NO. Read More

    Sunitinib in the treatment of thyroid cancer.
    Curr Med Chem 2017 Oct 6. Epub 2017 Oct 6.
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa. Italy.
    Background: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors. Read More

    Altered Epigenetic Mechanisms in Thyroid Cancer Subtypes.
    Mol Diagn Ther 2017 Oct 6. Epub 2017 Oct 6.
    Cellular and Molecular Endocrine Research Center (CMERC), Research Institute for Endocrine Sciences of Shahid Beheshti University of Medical Sciences, 19395-4763, Tehran, Iran.
    Thyroid carcinoma (TC) is the most frequent malignant neoplasm of the endocrine system. Molecular methods for diagnosis of invasive thyroid disease can be effectively adopted. Epigenetic factors play an important role in the diversity patterns of gene expression and the phenotypic and biological characteristics of TC subtypes. Read More

    A Unique Immunofluorescence Protocol to Detect Protein Expression in Vascular Tissues: Tacking a Long Standing Pathological Hitch.
    Turk Patoloji Derg 2017 Oct 6. Epub 2017 Oct 6.
    Department of Research, Bhopal Memorial Hospital & Research Centre, BHOPAL-38, INDIA.
    Objective: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging. Read More

    Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
    Anticancer Res 2017 10;37(10):5399-5405
    Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background/aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Read More

    Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report.
    Int J Surg Case Rep 2017 Sep 14;40:113-115. Epub 2017 Sep 14.
    Dept. of Medicine, University Jaume I (UJI), Castellon de la Plana, Spain.
    Introduction: Struma ovarii is a rare ovarian tumor, representing 0.5-1% of all ovarian tumors and 2-5% of ovarian teratomas. It is defined as an ovarian teratoma composed mostly of thyroid tissue. Read More

    Nonfunctional double parathyroid carcinoma with incidental thyroid micropapillary carcinoma: a rare case.
    Pan Afr Med J 2017 2;27:241. Epub 2017 Aug 2.
    Department of General Surgery, Gazi University Medical Faculty, Ankara, Turkey.
    Parathyroid carcinomas are rare endocrine tumors which comprise 0.3-5.6% of all causes of hyperparathyroidism. Read More

    Predictive factors and prognosis for recurrent laryngeal nerve invasion in papillary thyroid carcinoma.
    Onco Targets Ther 2017 11;10:4485-4491. Epub 2017 Sep 11.
    Thyroid and Parathyroid Surgery Center.
    Background: Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients.

    Methods: A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid Surgery Center of West China Hospital of Sichuan University were reviewed. Read More

    Intraoperative measurement of thyroglobulin in lymph node aspirates for the detection of metastatic papillary thyroid carcinoma.
    Onco Targets Ther 2017 11;10:4435-4441. Epub 2017 Sep 11.
    Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
    Background: Among patients with papillary thyroid carcinoma (PTC), 30%-80% have cervical lymph node (LN) metastases, which are most commonly located in the central compartment. However, preoperative ultrasonography identifies malignant central compartment LNs in only 20%-30% of cases. We aimed to evaluate the diagnostic value of intraoperative thyroglobulin (Tg) measurement in fine-needle aspirates (FNA-Tg) of suspicious metastatic LNs. Read More

    A meta-analysis of Hashimoto's thyroiditis and papillary thyroid carcinoma risk.
    Oncotarget 2017 Sep 27;8(37):62414-62424. Epub 2017 Jun 27.
    Department of Ultrasound, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
    Objective: It remains inconclusive whether Hashimoto's thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question.

    Results: Twenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. Read More

    Serum ghrelin levels in papillary thyroid carcinoma.
    Arch Endocrinol Metab 2017 Sep 18. Epub 2017 Sep 18.
    SBU Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
    Objective: Ghrelin plays a role in several processes of cancer progression, and numerous cancer types express ghrelin and its receptor. We aimed to investigate serum levels of ghrelin in patients with papillary thyroid carcinoma (PTC) and its association with the prognostic factors in PTC.

    Materials And Methods: We enrolled 54 patients with thyroid cancer (7 male, 47 female) and 24 healthy controls (6 male, 18 female) in the study. Read More

    MiR-577 inhibits papillary thyroid carcinoma cell proliferation, migration and invasion by targeting SphK2.
    Eur Rev Med Pharmacol Sci 2017 Oct;21(17):3794-3800
    Department of Thyroid and Breast Surgery, Linyi People's Hospital, Linyi, Shandong, China.
    Objective: MiRNAs are small, noncoding RNA molecules that serve as important regulators of cancer-related processes. Abnormal expression of miR-577 has been found in several tumors. However, the expression pattern and biological function of miR-577 in progression of papillary thyroid cancer (PTC) remain unknown. Read More

    Risk factors for predicting central lymph node metastasis in papillary thyroid microcarcinoma (CN0): a study of 273 resections.
    Eur Rev Med Pharmacol Sci 2017 Oct;21(17):3801-3807
    Department of General Surgery, Nanjing Hospital of Traditional Chinese Medicine, No.3 Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
    Objective: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma.

    Patients And Methods: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. Read More

    PD-L1 and PD-1 expression are correlated with distinctive clinicopathological features in papillary thyroid carcinoma.
    Diagn Pathol 2017 Oct 3;12(1):72. Epub 2017 Oct 3.
    Department of Pathology, Nara Hospital, Kindai University Faculty of Medicine, Ikoma-city, Nara, 630-0293, Japan.
    Background: Immune checkpoint blockade targeting PD-1/PD-L1 has shown efficacy in several types of cancers. However, the correlation between PD-L1/PD-1 expression and the specific clinicopathological features in papillary thyroid carcinoma (PTC) has not been investigated.

    Methods: We examined the immunohistochemical expression of PD-L1, PD-1, and BRAF V600E on whole-tissue sections from 126 cases of primary PTC more than 1 cm in size. Read More

    cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis.
    Diagn Pathol 2017 Oct 3;12(1):71. Epub 2017 Oct 3.
    Cleveland Clinic, Department of Pathology and Laboratory Medicine, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.
    Background: cMYC regulates approximately 15% of human genes and is involved in up to 20% of all human cancers. Reports discussing cMYC protein expression in thyroid carcinomas are limited, with controversies pertaining to cMYC expression patterns noted in the literature. The aims of the current study were to clarify patterns and intensities of cMYC expression in follicular cell-derived thyroid carcinomas across a spectrum of cancer morphologies and disease aggressivities, to correlate cMYC with BRAF(V600E) expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas. Read More

    Harefuah 2017 Sep;156(9):568-572
    Otolaryngology, Head and Neck Surgery, Rambam Medical Campus, Haifa, Israel.
    Aims: We aimed to better define the most appropriate therapeutic protocol for this type of tumor.

    Background: The incidence of well-differentiated thyroid carcinoma is rising and the mortality from the disease remains low for patients with early disease. Nevertheless, the survival of patients with advanced disease has not improved during the last four decades and a controversy still exists in the literature regarding the optimal treatment in patients with locally advanced (T4) differentiated thyroid carcinoma. Read More

    Patterns of Thyroid Cancers in Southeastern Nigeria: A 15 Year Histopathologic Review (2000-2014).
    J Clin Diagn Res 2017 Aug 1;11(8):EC16-EC19. Epub 2017 Aug 1.
    Senior Lecturer/Consultant, Department of Radiation Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria.
    Introduction: Thyroid Cancer (TC) continues to be the most common endocrine cancer with a worldwide increase in incidence over the last three decades. This trend has been reported in all continents except Africa, where detection is adjudged to be insufficient, making it imperative for us to re-evaluate the patterns in our environment.

    Aim: To determine the patterns of TCs in Southeastern Nigeria. Read More

    EIF1AX Mutation in a Patient with Hürthle Cell Carcinoma.
    Endocr Pathol 2017 Sep 30. Epub 2017 Sep 30.
    Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street 6th Floor, Philadelphia, PA, 19107, USA.
    The EIF1AX gene is a novel cancer gene that has been reported in the tumorigenesis of papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, and anaplastic thyroid carcinoma. A 71-year-old woman presented with a right thyroid mass, which was follicular neoplasm on cytology. The fine needle aspirate of the nodule was examined by next-generation sequencing and found to harbor EIF1AX and TP53 mutations. Read More

    Hashimoto's thyroiditis - an independent risk factor for papillary carcinoma.
    Braz J Otorhinolaryngol 2017 Sep 14. Epub 2017 Sep 14.
    Comenius University, Jessenius Faculty of Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, Martin, Slovakia.
    Introduction: The link between Hashimoto's thyroiditis (HT) and thyroid carcinoma (TC) has long been a topic of controversy.

    Objective: The aim of our study was to determine the prevalence of TC and HT coexistence in histopathologic material of thyroidectomized patients.

    Methods: In a retrospective study, the clinicohistopathologic data of 2117 patients (1738 females/379 males), who underwent total or partial thyroidectomy for thyroid gland disorder at a single institution from the 1st of January 2005 to the 31st of December 2014 were analyzed. Read More

    Management of the central compartment in differentiated thyroid carcinoma.
    Eur J Surg Oncol 2017 Sep 13. Epub 2017 Sep 13.
    The Clayman Thyroid Surgery and Thyroid Cancer Center, Tampa, FL, USA. Electronic address:
    Management of differentiated thyroid carcinoma (DTC) is gradually evolving with considerations of de-escalation of treatment and/or active surveillance in a significant proportion of patients on the basis of an improved understanding of the long-term disease and functional outcomes from both surgical and non-surgical approaches. This is fueled by improved risk stratification using clinicopathologic prognostic factors as determined through high resolution ultrasound and fine needle aspiration cytology. This paper discusses general recommendations for preoperative decision-making in the management of the central compartment in DTC with particular reference to micropapillary thyroid carcinoma and encapsulated follicular variant papillary thyroid carcinoma. Read More

    Malignant pleural effusion from papillary thyroid carcinoma diagnosed by pleural effusion cytology: A case report.
    Diagn Cytopathol 2017 Sep 27. Epub 2017 Sep 27.
    Department of Cytopathology, General Chest Diseases Hospital of Athens "SOTIRIA,", Greece.
    Papillary thyroid carcinoma (PTC) is by far the most common thyroid malignancy (over 85%) of all the thyroid cancers. It has excellent prognosis and 10-year survival rate in most of the cases (95%). Most of the tumors are indolent and do not recur or metastasize after removal. Read More

    Unilateral adrenal mass as the sole initial manifestation of differentiated thyroid cancer.
    BMJ Case Rep 2017 Sep 27;2017. Epub 2017 Sep 27.
    Department of Endocrinology and Metabolism, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India.
    Unilateral adrenal metastases without disseminated disease has rarely been reported in differentiated thyroid carcinoma (DTC). A 72-year-old female presented with vague abdominal discomfort and loss of appetite of 2 months duration. She had undergone left hemithyroidectomy for a benign thyroid nodule 18 years ago. Read More

    Papillary thyroid carcinoma of the isthmus: Total thyroidectomy or isthmusectomy?
    Am J Surg 2017 Sep 19. Epub 2017 Sep 19.
    Second Department of Propedeutic Surgery, Medical School, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
    Background: Papillary thyroid carcinoma (PTC) is the most common histological type of differentiated thyroid malignancy. Although the majority of PTC is located in the thyroid lobes, a small minority arise from the thyroid isthmus. The reported incidence of PTC arising in the thyroid isthmus ranges from 1% to 9. Read More

    Clinical response to radioactive iodine therapy for prophylactic central neck dissection is not superior to total thyroidectomy alone in cN0 patients with papillary thyroid cancer.
    Nucl Med Commun 2017 Sep 25. Epub 2017 Sep 25.
    Departments of aNuclear Medicine bThyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
    Objective: Prophylactic central neck dissection (pCND) is controversial in papillary thyroid carcinoma (PTC) without clinical positive lymph nodes. The aim of this study was to investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in clinically node-negative (cN0) PTC patients treated with total thyroidectomy (TT) alone or in combination with pCND.

    Patients And Methods: One-hundred and sixty-seven cN0 PTC patients who underwent TT alone (TT) or in combination with pCND (TT+pCND) in our hospital from January 2014 to August 2015 were evaluated retrospectively. Read More

    Psammomatous Squamous Cell Carcinoma of the Skin.
    Am J Dermatopathol 2017 Sep 20. Epub 2017 Sep 20.
    *University of Michigan Medical School, Ann Arbor, MI; and Departments of †Pathology, and ‡Dermatology, University of Michigan Medical School, Ann Arbor, MI.
    Psammoma bodies (PBs) are concentric, lamellated calcifications commonly observed in malignancies such as papillary thyroid carcinoma and serous carcinoma of the ovary in which they may serve prognostic value. PBs are rare in cutaneous squamous cell carcinoma (cSCC), with only 1 previously reported case. Here, we present 3 cases of cSCC displaying PBs. Read More

    The Association of Thyrotropin and Autoimmune Thyroid Disease in Developing Papillary Thyroid Cancer.
    Int J Endocrinol 2017 29;2017:5940367. Epub 2017 Aug 29.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
    Background: Papillary thyroid carcinoma (PTC) is the most common type of malignant thyroid neoplasm. However, the incidence of PTC with autoimmune thyroid disease (AITD) varies between studies. This study aims to investigate whether patients with AITD have increased incidence of PTC. Read More

    Concomitant high expression of ERα36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas.
    Sci Rep 2017 Sep 25;7(1):12279. Epub 2017 Sep 25.
    Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China.
    ERα, ERβ, PR, ERα36, EGFR and HER2 mRNA and protein expression in papillary thyroid carcinoma (PTC) were examined by real time RT-PCR and immunohistochemical staining. The mRNA and protein expression of ERα and PR were gradually increased and those of ERβ were gradually decreased from normal thyroid tissues to nodular hyperplasias (P < 0.05) and to PTCs (P < 0. Read More

    Ultrasonic diagnosis for thyroid Hürthle cell tumor.
    Cancer Biomark 2017 Sep;20(3):235-240
    Department of Ultrasound, Peking University First Hospital, Beijing 100034, China.
    Objective: This study aims to evaluate the diagnostic value of ultrasound in thyroid Hürthle cell tumors.

    Methods: A retrospective analysis was carried out on 27 patients with thyroid Hürthle cell tumors, in terms of the size, shape, boundary, echo, aspect ratio, cystic degeneration, calcification, peripheral halo sign and blood supply of the tumor, through surgical pathological validation. Then, these were compared with postoperative pathological results. Read More

    Follicular adenoma in ectopic thyroid. A case-report.
    Int J Surg Case Rep 2017 Sep 14;40:94-96. Epub 2017 Sep 14.
    Hospital of Cava de' Tirreni, Università degli studi di Salerno, Italy. Electronic address:
    Introduction: The term ectopic thyroid refers to the presence of thyroid tissue located far from its usual anatomic placement and with no vascular connection to the main gland. The presence of swelling in atypical locations is diagnostically differentiated from other pathologies like pleomorphic adenoma or carcinoma, inflammatory lesions like sialadenitis, neurogenic tumors, paraganglioma, fibrolipoma and lymphadenopaties of diverse etiologies.

    Presentation Of Case: Here we present the case of a submandibular ectopic thyroid in a 67year old woman. Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).
    Cancer 2017 Sep 20. Epub 2017 Sep 20.
    Department of Anatomic Pathology and Histology, "A. Gemelli" University Polyclinic Foundation, University Rome, Italy.
    Background: The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk of malignancy (ROM) mostly in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories. In this multi-institutional, retrospective study, the authors investigated variations in the impact of an NIFTP diagnosis on the associated ROM for each TBSRTC category with an emphasis on the influence of pathologist and institutional diagnostic thresholds on the ROM.

    Methods: Baseline data on cytology and histology diagnostic categories were collected over a 3-year period at 3 academic center hospitals (institutions A, B, and C). Read More

    Molecular genotyping of noninvasive encapsulated follicular variant of papillary thyroid carcinoma.
    Histopathology 2017 Sep 20. Epub 2017 Sep 20.
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.
    Aim: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has been managed as low-risk malignancy. Recently, a proposal was made to reclassify this tumor type as a premalignant lesion and rename it noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). However, a comprehensive study on molecular genotype-phenotype correlations of encapsulated FVPTC is lacking. Read More

    RDM1 gene overexpression represents a therapeutic target in papillary thyroid carcinoma.
    Endocr Connect 2017 Sep 22. Epub 2017 Sep 22.
    J Tan, Nuclear Medicine, Tianjin Medical University General Hospital, tianjin, China.
    RAD52 motif containing 1 (RDM1) encodes the RAD52 protein involved in DNA double-strand break repair and recombination events. However, the importance of RDM1 in papillary thyroid carcinoma (PTC) is largely unknown. In the present study, we examined the role of RDM1 in thyroid cancer. Read More

    The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population.
    Oncotarget 2017 Aug 6;8(35):58304-58308. Epub 2017 Apr 6.
    Oncology Clinic, Holycross Cancer Centre, Kielce, Poland.
    Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p. Read More

    Papillary thyroid carcinoma with nodular fasciitis-like stroma: A rare variant with distinctive morphology.
    Indian J Pathol Microbiol 2017 Jul-Sep;60(3):390-392
    Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
    Papillary thyroid carcinoma (PTC) is a common malignancy with multiple variants, some of which are rarely encountered in routine surgical pathology practice. PTC with exuberant nodular fasciitis-like stroma or PTC with fibromatosis-like stroma is one such variant. This tumor is characterized by an abundant stromal component with an intervening epithelial component with the typical morphologic features of PTC. Read More

    Correlation between human epidermal growth factor receptor 2 oncoprotein expression and some prognostic factors in papillary thyroid carcinoma.
    Indian J Pathol Microbiol 2017 Jul-Sep;60(3):324-327
    Medical Students Research Committee, Shahed University, Tehran, Iran.
    Background: Thyroid cancer is one of the increasing cancer diagnoses in the United States. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. There are a few researches done determining the role of human epidermal growth factor receptor 2 HER2 (erbB-2) in PTC prognosis. Read More

    Breast cancer metastases to the thyroid gland - an uncommon sentinel for diffuse metastatic disease: a case report and review of the literature.
    J Med Case Rep 2017 Sep 22;11(1):269. Epub 2017 Sep 22.
    Department of Thyroid & Endocrine Surgery, Hammersmith Hospital, Imperial College Hospitals NHS Trust, London, W12 0HS, UK.
    Background: Metastases to the thyroid are rare. The most common primary cancer to metastasize to the thyroid is renal cell carcinoma, followed by malignancies of the gastrointestinal tract, lungs, and skin, with breast cancer metastases to the thyroid being rare. Overall, the outcomes in malignancies that have metastasized to the thyroid are poor. Read More

    Role of Dicer1 in thyroid cell proliferation and differentiation.
    Cell Cycle 2017 Sep 21. Epub 2017 Sep 21.
    a Istituto di Endocrinologia ed Oncologia Sperimentale - CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II" , Naples , Italy.
    DICER1 plays a central role in the biogenesis of microRNAs and it is important for normal development. Altered microRNA expression and DICER1 dysregulation have been described in several types of tumors, including thyroid carcinomas. Recently, our group identified a new somatic mutation (c. Read More

    Computed tomography features of the major salivary glands after radioactive iodine ablation in patients with papillary thyroid carcinoma.
    Radiol Med 2017 Sep 20. Epub 2017 Sep 20.
    Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, 75, Bokji-ro, Busanjin-gu, Busan, 47392, South Korea.
    Objective: No previous study has investigated computed tomography (CT) features of the major salivary glands (MSGs) after postoperative radioactive iodine ablation (RIA). This study aimed to assess CT features of the MSGs after RIA in patients with papillary thyroid carcinoma (PTC).

    Methods: The study population comprised consecutively registered PTC patients who had undergone total thyroidectomy, RIA, follow-up neck ultrasonography (US), and neck CT. Read More

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