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    16724 results match your criteria Thyroid Papillary Carcinoma

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    Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-κB signaling pathway.
    Biomed Pharmacother 2018 Apr 17;103:490-498. Epub 2018 Apr 17.
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, China. Electronic address:
    Papillary thyroid carcinoma (PTC) is the most common endocrine carcinoma. Our previous study revealed that punicalagin (PUN), an active component from pomegranate, triggered autophagic cell death and DNA damage response (DDR) in papillary thyroid carcinoma BCPAP cells. But the detailed anti-cancer mechanisms of punicalagin against PTC still remained to be further explored. Read More

    Histopathological pattern of thyroid diseases in Zaria: A 10-year review.
    Niger Postgrad Med J 2018 Jan-Mar;25(1):37-42
    Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.
    Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens.

    Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Read More

    Dynamic risk stratification system in post-lobectomy low-risk and intermediate-risk papillary thyroid carcinoma patients.
    Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
    Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine,20 Ilsan-ro, Wonju, Gangwon-do,, 26426, Korea.
    Objective: The dynamic risk stratification (DRS) and its current definition of each response-to-therapy category in post-lobectomy papillary thyroid carcinoma (PTC) patients have not been well studied. This study aimed to validate the DRS system and to investigate useful thyroglobulin (Tg) or anti-Tg antibody (Ab)-related parameters in defining each response-to-therapy category DESIGN: Retrospective observational study.

    Patients: This historical cohort study included 619 patients with PTC treated by thyroid lobectomy. Read More

    Young Age Is Associated With Increased Rates of Residual & Recurrent Pediatric Differentiated Thyroid Carcinoma.
    Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
    Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada.
    Objective: Differentiated thyroid carcinoma is rare in young children. There are conflicting data as to whether disease in this age group differs from that in adolescents and specifically, if it is more aggressive. Current practice guidelines do not differentiate treatment between these groups, but speculate that differences may exist. Read More

    An Analysis of The American Joint Committee on Cancer 8th Edition T Staging System for Papillary Thyroid Carcinoma.
    J Clin Endocrinol Metab 2018 Apr 16. Epub 2018 Apr 16.
    Department of Head and Neck Surgery, Liverpool Hospital, NSW, Australia.
    Background: The American Joint Committee on Cancer (AJCC) removed microscopic extrathyroidal extension (m-ETE) from the 8th edition T staging for papillary thyroid carcinoma (PTC) based on increasing evidence that it is not an independent prognostic factor.

    Objectives: We aimed to compare the prognostic performance of AJCC 7th (pT7) and 8th (pT8) edition T stage systems, particularly in patient's ≥55 years old without macroscopic ETE or distant metastases, in whom T classification impacts TNM stage.

    Method: A retrospective analysis of disease-free survival (DFS) in 577 patients with PTC comparing pT8 versus pT7 using the Akaike information criterion (AIC), Harrell's C-index and Proportion of Variation Explained (PVE). Read More

    Thyroid-Like Intrahepatic Cholangiocarcinoma: Report of a Case and Review of the Literature.
    Int J Surg Pathol 2018 Apr 1:1066896918769381. Epub 2018 Apr 1.
    1 Department of Pathology, Fuzhou General Hospital of PLA, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou City, Fujian Province, China.
    Intrahepatic cholangiocarcinoma is a relatively uncommon malignant neoplasm. We recently encountered an unusual case of intrahepatic cholangiocarcinoma that histologically resembled a thyroid carcinoma. A thorough review of the English literature revealed only 2 similar cases that have been previously reported. Read More

    Overexpression of epidermal growth factor receptor and its downstream effector, focal adhesion kinase, correlates with papillary thyroid carcinoma progression.
    Int J Exp Pathol 2018 Apr 17. Epub 2018 Apr 17.
    Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Belgrade-Zemun, Serbia.
    Epidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between EGFR and FAK expression and their possible correlation with the clinical phenotype of patients with papillary thyroid carcinoma (PTC). Expression profiles of EGFR and FAK were analysed in PTC tissue samples (n = 104) by immunohistochemistry and Western blotting. Read More

    Positive Surgical Margins in Favorable-Stage Differentiated Thyroid Cancer.
    Am J Clin Oncol 2018 Apr 16. Epub 2018 Apr 16.
    Departments of Radiation Oncology.
    Objective: The significance of positive margin in favorable-stage well-differentiated thyroid cancer is controversial. We report outcomes of positive-margin patients with a matched-pair comparison to a negative-margin group.

    Materials And Methods: A total of 25 patients with classic-histology papillary or follicular carcinoma, total thyroidectomy +/- node dissection, stage T1-3N0-1bM0, positive surgical margin at primary site, adjuvant radioactive iodine (I-131), and age older than 18 years were treated between 2003 and 2013. Read More

    The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells.
    J Cell Biochem 2018 Apr 16. Epub 2018 Apr 16.
    Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.
    Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins. Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC-133, and papillary K1 thyroid carcinoma cells were rich in α-2,6, α-2,3, sialic acid, and α-1,6 fucose residues. Read More

    Dual Pathologies of Parathyroid Adenoma and Papillary Thyroid Cancer on Fluorocholine and Fluorodeoxyglucose PET/CT.
    Nucl Med Mol Imaging 2018 Apr 25;52(2):154-158. Epub 2017 Jul 25.
    1Department of Nuclear Medicine, PGIMER, Sector-12, Chandigarh, 160012 India.
    F-Fluorocholine (FCH) PET/CT is evolving as a functional imaging modality for the preoperative imaging of abnormal parathyroid tissue(s) helping to localize eutopic and ectopic parathyroid tissue and limit the extent of surgery. FCH PET/CT may show incidental uptake in various thyroid lesions necessitating further evaluation, whereas the role of F-fluorodeoxyglucose (FDG) PET/CT in the detection of incidental thyroid nodules is well documented. The case of a middle-aged woman with dual pathology of parathyroid adenoma and papillary thyroid cancer detected on FCH and FDG PET/CT is presented. Read More

    Pediatric Patient With Cerebral Metastasis From Papillary Thyroid Cancer.
    Clin Nucl Med 2018 Apr 13. Epub 2018 Apr 13.
    From the Department of Radiology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
    Brain metastasis from papillary thyroid carcinoma is uncommon. Concurrent cerebral and pulmonary metastases from papillary thyroid carcinoma is rare, especially in pediatric patients. We report a case of a brain metastasis revealed on post-therapy I scan in a 12 year old girl with thyroid cancer who also had diffuse pulmonary metastases which were partially responsive to sequential I therapy. Read More

    SONOGRAPHIC FEATURES OF MULTIFOCAL PAPILLARY THYROID CARCINOMAS.
    Endocr Pract 2018 Apr;24(4):351-360
    Objective: It is uncertain whether papillary thyroid carcinomas (PTCs) of the same subtype display similar sonographic features. This retrospective analysis of pre-operative sonographic and pathologic findings aimed to assess whether PTCs of the same subtype share sonographic features.

    Methods: Before undergoing thyroid surgery, 137 patients underwent ultrasound (US) examination. Read More

    Reduced expression of oestrogen receptor-β is associated with tumour invasion and metastasis in oestrogen receptor-α-negative human papillary thyroid carcinoma.
    Int J Exp Pathol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.
    Oestrogens play an important role in the development and progression of papillary thyroid carcinoma (PTC) through oestrogen receptor (ER)-α and -β, which may exert different or even opposing actions in PTC. The roles of ERβ in ERα-negative PTC are still not clear. This study investigated the expression dynamics of ERβ1 (wild-type ERβ) and its clinical significance in female ERα-negative PTC patients. Read More

    In papillary thyroid carcinoma, expression by immunohistochemistry of BRAF V600E, PD-L1, and PD-1 is closely related.
    Virchows Arch 2018 Apr 12. Epub 2018 Apr 12.
    Department of Pathology, Nara Hospital, Kindai University Faculty of Medicine, Ikoma, Nara, 630-0293, Japan.
    Immune checkpoint inhibitor therapies targeting PD-L1/PD-1 have been shown to be effective in treating several types of human cancer. In papillary thyroid carcinoma (PTC), little is known about the expression of PD-L1/PD-1 in the tumor microenvironment or its potential correlation with BRAF V600E mutation status. In this study, we examined the expression of PD-L1, PD-1, and BRAF V600E in PTC by immunohistochemistry and investigated the clinical significance of expression status. Read More

    Early evolutionary divergence between papillary and anaplastic thyroid cancers.
    Ann Oncol 2018 Apr 10. Epub 2018 Apr 10.
    Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital Barcelona, Spain.
    Background: Papillary thyroid cancer (PTC) is the most common thyroid carcinoma and exhibits an almost uniformly good prognosis, while anaplastic thyroid cancer (ATC) is less frequent and is one of the most aggressive cancers usually resistant to conventional treatment. Current hypothesis posits that ATC derives from PTC through the progressive acquisition of a discrete number of genomic alterations and implies that the mutational landscape of ATC resembles that of PTC. However, the clinical behaviour of ATC and PTC is radically different. Read More

    Role of Preablative Stimulated Thyroglobulin in Prediction of Nodal and Distant Metastasis on Iodine Whole-Body Scan.
    Indian J Nucl Med 2018 Apr-Jun;33(2):93-98
    Department of Endocrinology, Diabetes and Metabolism, Narayana Health City, Bengaluru, Karnataka, India.
    Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (I WBS) in the management of low-to-intermediate-risk DTC patients. Read More

    Metaplastic breast carcinoma composed of epithelial-myoepithelial carcinoma and squamous cell carcinoma: A case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0364
    Department of Oncology.
    Rationale: Metaplastic breast carcinomas are a group of breast malignancies with varying histomorphological characteristics and prognoses. The tumor composed of epithelial -myoepithelial carcinoma and squamous cell carcinoma was not reported previously.

    Patient Concerns: An 81-year-old woman presented with a palpable nodule in the left breast for 4 days. Read More

    Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter.
    Arch Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Department of Clinical & Experimental Medicine, University Hospital of Messina, Messina, Italy.
    Objective: Incidental thyroid cancers (ITCs) are often microcarcinomas; among them, the most frequent histotype is the papillary one. The purpose of this study was to evaluate the rate of papillary thyroid cancer (PTC) in patients thyroidectomized for benign multinodular goiter.

    Subject And Methods: We retrospectively evaluated the histological incidence of PTC in 207 consecutive patients who, in a 1-year period, underwent thyroidectomy for benign multinodular goiter. Read More

    Cytopathology of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: A comparative study with similar patterned papillary thyroid carcinoma variants.
    Cytopathology 2018 Apr 11. Epub 2018 Apr 11.
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
    Objective: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently described, indolent thyroid tumor, with well-defined histopathological diagnostic criteria. Cytology features are not well documented. We reviewed cytology of histologically proven cases of NIFTP and some of its common differentials to look for salient diagnostic features. Read More

    The Spectrum of Thyroid Gland Pathology in Carney Complex: The Importance of Follicular Carcinoma.
    Am J Surg Pathol 2018 May;42(5):587-594
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
    The initial description of Carney complex (CNC) in 1985 included myxomas, spotty skin pigmentation, and endocrine overactivity (of the adrenal, the pituitary, and the testis). In 1997, thyroid neoplasms were found in 3 patients with CNC and involvement of the gland in the syndrome was apparent. Herein, we describe the clinical, pathologic, and follow-up findings in 26 patients with CNC and a disorder of the thyroid gland. Read More

    Anaplastic lymphoma kinase (ALK) gene rearrangements in radiation-related human papillary thyroid carcinoma after the Chernobyl accident.
    J Pathol Clin Res 2018 Apr 6. Epub 2018 Apr 6.
    Bundeswehr Institute of Radiobiology, Munich, Germany.
    Childhood radiation exposure has been associated with increased papillary thyroid carcinoma (PTC) risk. The role of ALK gene rearrangements in radiation-related PTC remains unclear, but STRN-ALK fusions have recently been detected in PTCs from radiation-exposed persons after Chernobyl using targeted next-generation sequencing and RNA-seq. We investigated ALK and RET gene rearrangements as well as known driver point mutations in PTCs from 77 radiation-exposed patients (mean age at surgery 22. Read More

    MiR-144-3p promotes the tumor growth and metastasis of papillary thyroid carcinoma by targeting paired box gene 8.
    Cancer Cell Int 2018 4;18:54. Epub 2018 Apr 4.
    1Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, 155 NanJing North Road, Shenyang, 110000 China.
    Background: Paired box gene 8 (PAX8) is expressed in and indispensable to thyroid development. MiR-144-3p is found dys-regulated in cancers, and it can block the expression of target gens. This study sought to understand the effect of MiR-144-3p in papillary thyroid carcinoma (PTC) as well as the associated mechanisms. Read More

    Impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features on the Bethesda system for reporting thyroid cytopathology: a multi-institutional study in five Asian countries.
    Pathology 2018 Apr 6. Epub 2018 Apr 6.
    Department of Pathology, Nara Hospital, Kindai University Faculty of Medicine, Nara, Japan.
    Several Western studies showed that the recent introduction of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) significantly decreased risk of malignancy for cytological diagnostic categories. We aimed to determine the impact of NIFTP on risk of malignancy within a cohort of thyroid nodules from Asian countries, and to compare distribution of diagnostic categories between NIFTP and invasive encapsulated follicular variant of papillary thyroid carcinoma (eFV-PTC). Consecutive thyroid fine-needle aspirates from six institutions were retrospectively analysed. Read More

    Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background.
    Mitochondrion 2018 Apr 6. Epub 2018 Apr 6.
    Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal; Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, Portugal; Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address:
    We conducted the first systematic omics study of the oncocytic phenotype in 488 papillary thyroid carcinomas (PTC) from The Cancer Genome Atlas. Oncocytic phenotype is secondary to PTC, being unrelated to several pathologic scores. The nuclear genome had low impact on this phenotype (except in specific copy number variation), which was mostly driven by the significant accumulation of mitochondrial DNA non-synonymous and frameshift mutations at high heteroplasmy levels. Read More

    LncRNA SNHG12 promotes the proliferation and metastasis of papillary thyroid carcinoma cells through regulating wnt/β-catenin signaling pathway.
    Cancer Biomark 2018 Mar 30. Epub 2018 Mar 30.
    Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
    Objective: To investigate the expression and role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 12 (SNHG12) in papillary thyroid carcinoma (PTC).

    Methods: The relative expression levels of lncRNA SNHG12 (hereinafter referred to as SNHG12) in 42 pairs of PTC tissues and para-carcinoma tissues were detected via quantitative reverse transcription polymerase chain reaction (qRT-PCR). SNHG12 specific interference sequences were designed and synthesized. Read More

    Molecular markers in well-differentiated thyroid cancer.
    Eur Arch Otorhinolaryngol 2018 Apr 6. Epub 2018 Apr 6.
    International Head and Neck Scientific Group, Padua, Italy.
    Purpose: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. Read More

    Network-based meta-analysis in the identification of biomarkers for papillary thyroid cancer.
    Gene 2018 Apr 3. Epub 2018 Apr 3.
    Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
    Papillary thyroid carcinoma (PTC) has been increasing across the world with incomplete understanding of its pathogenesis. We aimed to investigate gene alterations and biomarkers contributing to PTC development. A total of five eligible microarray datasets including 94 PTC and 81 normal thyroid samples were included to identify gene expression signatures. Read More

    Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma.
    BMC Cancer 2018 Apr 5;18(1):390. Epub 2018 Apr 5.
    Thyroid and Parathyroid Surgery Group of West China Hospital of Sichuan University, Chengdu, China.
    Background: Hyperfibrinogenemia is increasingly being recognized as an important risk factor related to cancer stage, development and outcomes. We evaluated whether preoperative serum fibrinogen levels predict recurrence of papillary thyroid carcinoma (PTC).

    Methods: We retrospectively collected data for 1023 PTC patients who underwent surgery at our institution from Aug 2014 to Aug 2016. Read More

    LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway.
    Mol Med Rep 2018 Apr 5. Epub 2018 Apr 5.
    Department of Breast Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
    The incidence of thyroid cancer has increased the past few decades, the most frequent type has been identified to be the papillary thyroid carcinoma (PTC). Following thyroidectomy, radioiodine ablation treatment on PTC is routinely performed. However, many patients do not benefit from radioiodine therapy. Read More

    Unusual Presentation of Differentiated Thyroid Cancer Metastasis.
    Int Arch Otorhinolaryngol 2018 Apr 14;22(2):167-170. Epub 2017 Jul 14.
    Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
     The rates of thyroid cancers are on a rise, especially well-differentiated thyroid cancers. This could be partly due to newer diagnostic modalities, like high-resolution ultrasound, that can pick up smaller lesions. Differentiated thyroid cancers with distant metastases are not common, and even rarer is the initial presentation with complaints not related to the neck. Read More

    Prognostic value of the 8 tumor-node-metastasis classification for follicular carcinoma and poorly differentiated carcinoma of the thyroid in Japan.
    Endocr J 2018 Apr 4. Epub 2018 Apr 4.
    Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan.
    Follicular thyroid carcinoma (FTC), a form of differentiated thyroid carcinoma, is the second most common malignancy arising from thyroid follicular cells. Recently, the tumor-node-metastasis (TNM) classification for differentiated thyroid carcinoma was revised from the 7 to the 8 edition. The diagnostic criteria for poorly differentiated carcinoma (PDC) were also updated in the latest World Health Organization (WHO) classification. Read More

    The mTOR Kinase Inhibitor CZ415 Inhibits Human Papillary Thyroid Carcinoma Cell Growth.
    Cell Physiol Biochem 2018 Mar 28;46(2):579-590. Epub 2018 Mar 28.
    Background/aim: Mammalian target of rapamycin (mTOR) plays an important role in papillary thyroid carcinoma (PTC) cell progression. CZ415 is a novel, highly-efficient and specific mTOR kinase inhibitor. The current study tested the potential anti-tumor activity of CZ415 in human PTC cells. Read More

    Inhibiting TRK Proteins in Clinical Cancer Therapy.
    Cancers (Basel) 2018 Apr 4;10(4). Epub 2018 Apr 4.
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
    Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer therapeutics. The TRK family contains three members, TRKA, TRKB, and TRKC, and these proteins are encoded by the genes NTRK1, NTRK2, and NTRK3, respectively. Read More

    Lenvatinib-induced renal failure: two first-time case reports and review of literature.
    Expert Opin Drug Metab Toxicol 2018 Apr 13:1-7. Epub 2018 Apr 13.
    a Head and Neck Cancer Medical Oncology 3 Department , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
    Introduction: Lenvatinib (LEN) is a multi-kinase anti-angiogenic drug recently approved in several cancers. LEN is not easily manageable due to its complex safety profile. Proteinuria and renal failure (RF) were reported among the most frequent LEN-induced adverse events (AEs), often leading to discontinuations or dose modifications. Read More

    Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features and Its Impact on the Risk of Malignancy in the Bethesda System for Reporting Thyroid Cytopathology: An Institutional Experience.
    J Pathol Transl Med 2018 Apr 3. Epub 2018 Apr 3.
    Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
    Background: This study was performed to analyze cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and its impact on the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).

    Materials And Methods: 5549 cases of thyroid fine-needle aspiration cytology (FNAC) diagnosed between 2012 and 2014 were included in this study. Diagnostic categories based on TBSRTC were compared with final surgical diagnoses, and the ROM in each category was calculated both including and excluding NIFTP from the malignant lesions. Read More

    Comparison of Immunohistochemistry and Direct Sequencing Methods for Identification of the BRAF Mutation in Papillary Thyroid Carcinoma.
    Ann Surg Oncol 2018 Apr 2. Epub 2018 Apr 2.
    Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
    Background: BRAF mutation is the most common somatic variant in papillary thyroid carcinoma (PTC) and is associated with aggressive prognostic factors. The conventional detection method for BRAF mutations is polymerase chain reaction followed by Sanger sequencing. Recently, an immunohistochemistry (IHC) method using a BRAF-specific antibody (VE1) has been developed and widely adopted in the clinics; however, there is a lack of evidence regarding the comparability of the IHC and Sanger sequencing methods. Read More

    Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer.
    Open Access Maced J Med Sci 2018 Mar 2;6(3):435-441. Epub 2018 Mar 2.
    Trakia University, Medical Faculty, Department of General and Clinical Pathology, Stara Zagora, Bulgaria.
    Background: Papillary thyroid carcinoma (PTC) accounts for 80% of the thyroid malignancies that are characterised by slow growth and an excellent prognosis. Over-expression of SMAD4 protein restores TGF-β signalling, determines a strong increase in anti-proliferative effect and reduces invasive potential of tumour cells expressing it.

    Aim: The study aimed to analyse the immunohistochemical expression of TGF-β1 and its downstream phosphorylated SMAD4, element and of the inhibitory SMAD7 PTC variants and their association with the localisation of TAMs within the tumour microenvironment. Read More

    Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma.
    Cold Spring Harb Mol Case Stud 2018 Apr 2;4(2). Epub 2018 Apr 2.
    BC Children's Hospital Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.
    Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A fusion was identified in one tumor, with outlier expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. Read More

    Diagnosing between papillary carcinoma and reactive papillary changes in an infarcted thyroid nodule after fine needle aspiration and accompanied by a synchronous brain stem astrocytoma.
    North Clin Istanb 2018 10;5(1):67-71. Epub 2018 Jan 10.
    Department of General Surgery, Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
    A 22-year-old patient underwent fine needle aspiration of a nodule at the outer center of the right lobe of the thyroid, and it was reported to be Bethesda system category IV, Hurthle cell follicular neoplasia. The patient, who persented to Onsekiz Mart University Research and Application Hospital, underwent surgery. During right total thyroidectomy, an almost totally infarcted nodule and papillary structures around these infarcted areas were detected. Read More

    Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism.
    Case Rep Obstet Gynecol 2018 21;2018:2091082. Epub 2018 Jan 21.
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes.

    Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Read More

    Efficiency of the Bethesda System for Thyroid Cytopathology.
    Cir Esp 2018 Mar 28. Epub 2018 Mar 28.
    Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario de La Princesa, Madrid, España; Departamento de Cirugía, Universidad Autónoma de Madrid, Madrid, España.
    Introduction: Fine-needle aspiration biopsies are a key tool for preoperative assessment of thyroid nodules, and the Bethesda system is the preferred method to report cytological analysis. The purpose of this study is to assess the efficiency of the Bethesda system to identify the malignancy risk of thyroid nodules.

    Methods: Patients who underwent thyroid surgery between June 2010 and June 2017 were included. Read More

    Solid Papillary Breast Carcinomas Resembling the Tall Cell Variant of Papillary Thyroid Neoplasms (Solid Papillary Carcinomas with Reverse Polarity) Harbor Recurrent Mutations Affecting IDH2 and PIK3CA: A Validation Cohort.
    Histopathology 2018 Mar 30. Epub 2018 Mar 30.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Aims: Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histologic type of breast cancer that morphologically resembles the tall cell variant of papillary thyroid carcinoma. BPTCs are characterized by IDH2 R172 hotspot somatic mutations or mutually exclusive TET2 somatic mutations, concurrently with mutations affecting PI3K pathway-related genes. We sought to characterize their histology, and investigate the frequency of IDH2 and PIK3CA mutations in an independent cohort of BPTCs, as well as in conventional solid papillary carcinomas (SPCs). Read More

    A Clinical Decision Support System Using Ultrasound Textures and Radiologic Features to Distinguish Metastasis From Tumor-Free Cervical Lymph Nodes in Patients With Papillary Thyroid Carcinoma.
    J Ultrasound Med 2018 Mar 30. Epub 2018 Mar 30.
    Solid Tumor Research Center, Faculty of Medicine, Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran.
    Objectives: This study investigated the potential of a clinical decision support approach for the classification of metastatic and tumor-free cervical lymph nodes (LNs) in papillary thyroid carcinoma on the basis of radiologic and textural analysis through ultrasound (US) imaging.

    Methods: In this research, 170 metastatic and 170 tumor-free LNs were examined by the proposed clinical decision support method. To discover the difference between the groups, US imaging was used for the extraction of radiologic and textural features. Read More

    The role of septin 7 in physiology and pathological disease: A systematic review of current status.
    J Cell Mol Med 2018 Mar 30. Epub 2018 Mar 30.
    Department of Pathology, Tianjin Union Medical Center, Tianjin, China.
    Septins are a conserved family of cytoskeletal GTPases present in different organisms, including yeast, drosophila, Caenorhabditis elegans and humans. In humans, septins are involved in various cellular processes, including exocytosis, apoptosis, leukemogenesis, carcinogenesis and neurodegeneration. Septin 7 is unique out of 13 human septins. Read More

    Prognostic value of long non-coding RNA BLACAT1 in patients with papillary thyroid carcinoma.
    Cancer Cell Int 2018 27;18:47. Epub 2018 Mar 27.
    1Department of Endocrinology and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400043 China.
    Background: Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients with papillary thyroid cancer (PTC) remain unknown.

    Methods: The expression profile of BLACAT1 in 87 PTC patients (case group) and 36 patients with nodular goiter (control group) were investigated by qRT-PCR. Read More

    AZD5153, a novel BRD4 inhibitor, suppresses human thyroid carcinoma cell growth in vitro and in vivo.
    Biochem Biophys Res Commun 2018 May 31;499(3):531-537. Epub 2018 Mar 31.
    Department of Breast Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:
    The development of novel anti-papillary thyroid carcinoma agents is urgent. AZD5153 is a novel and specific Bromodomain-containing protein 4 (BRD4) inhibitor. Here, we show that AZD5153 dose-dependently inhibited survival, proliferation and cell cycle progression in TPC-1 cells and primary human thyroid carcinoma cells. Read More

    Thyroid nodules and cancer in children and adolescents affected by hashimoto's thyroiditis.
    Br J Radiol 2018 Apr 9:20180014. Epub 2018 Apr 9.
    Department of Radiology, Soonchunhyang University Bucheon Hospital , Bucheon , Korea.
    Objective: To investigate the rates of thyroid nodules and cancer in pediatric cases of Hashimoto's thyroiditis (HT) in Korea.

    Methods: We retrospectively reviewed 89 pediatric and adolescent patients (age, 3-18.0 years) with HT who underwent thyroid ultrasonography (US) at our institution from February 2006 to July 2016. Read More

    Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer.
    Eur Thyroid J 2018 Mar 10;7(2):95-101. Epub 2018 Jan 10.
    Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada.
    Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy.

    Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC.

    Design: Retrospective study. Read More

    A Case Report of Syndromic Multinodular Goitre in Adolescence: Exploring the Phenotype Overlap between Cowden and DICER1 Syndromes.
    Eur Thyroid J 2018 Jan 21;7(1):44-50. Epub 2017 Nov 21.
    Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia.
    Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome.

    Material And Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Read More

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