Search our Database of Scientific Publications and Authors

I’m looking for a

    16529 results match your criteria Thyroid Papillary Carcinoma

    1 OF 331

    A false-positive I-131 finding of duodenum diverticulum in thyroid cancer evaluation by SPECT/CT: A case report.
    Medicine (Baltimore) 2018 Feb;97(8):e9997
    Department of Nuclear Medicine, West China Hospital of Sichuan University, Guoxue Alley, Chengdu, Sichuan, People's Republic of China.
    Rationale: Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. Read More

    US Fine-Needle Aspiration Biopsy for Thyroid Malignancy: Diagnostic Performance of Seven Society Guidelines Applied to 2000 Thyroid Nodules.
    Radiology 2018 Feb 21:171074. Epub 2018 Feb 21.
    From the Departments of Radiology (E.J.H.) and Biostatistics (S.Y.K.), Ajou University School of Medicine, Wonchon-Dong, Yeongtong-Gu, Suwon 443-380, Korea; Department of Radiology, GangNeung Asan Hospital, Gangneung-si, Gangwon-do, Korea (D.G.N.); Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, Korea (D.G.N.); Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (J.H.B.); Department of Radiology, Thyroid Center, Daerim St. Mary's Hospital, Seoul, Korea (J.Y.S.); and Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea (J.H.K.).
    Purpose To compare the diagnostic performance of ultrasonography (US)-based fine-needle aspiration biopsy (FNAB) criteria from seven international societies in the detection of thyroid malignancy. Materials and Methods This study included a total of 2000 consecutive thyroid nodules (≥1 cm) in 1802 patients with final diagnoses from January 2010 to May 2011. US features of the thyroid nodules were retrospectively reviewed and were classified according to the categories defined by the seven international society guidelines. Read More

    Risk Factors for Recurrence After Treatment of N1b Papillary Thyroid Carcinoma.
    Ann Surg 2018 Feb 16. Epub 2018 Feb 16.
    Departments of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Objectives: To examine risk factors for posttreatment recurrence in papillary thyroid carcinoma (PTC) patients with initial presentation of lateral neck metastasis (N1b).

    Summary Of Background Data: N1b PTC recurs after definitive treatment.

    Methods: Study subjects were 437 consecutive PTC patients who underwent total thyroidectomy and therapeutic neck dissection of central and lateral compartments and postoperative radioactive iodine ablation therapy. Read More

    Proposal for an extended pTNM classification of thyroid carcinoma : Commentary on deficits of the 8th edition of the TNM classification.
    Pathologe 2018 Feb 19. Epub 2018 Feb 19.
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany.
    In the 8th edition of the TNM classification of thyroid carcinomas, which was introduced in 2017, carcinomas with minimal extrathyroidal extension are no longer mentioned, which might cause problems. These tumors were explicitly categorized in previous TNM classifications (5-7th editions). Studies on the prognostic relevance of minimal extrathyroidal extension have shown conflicting results. Read More

    Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
    Cancer Microenviron 2018 Feb 17. Epub 2018 Feb 17.
    Departamento de Ciências Básicas da Saúde and Laboratório de Biologia Celular, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Prédio III, Sala 613, Porto Alegre, RS, CEP 90050-170, Brazil.
    The incidence of differentiated thyroid cancer has been increasing. Nevertheless, its molecular mechanisms are not well understood. In recent years, extracellular nucleotides and nucleosides have emerged as important modulators of tumor microenvironment. Read More

    A rare case of ectopic papillary thyroid carcinoma transformed into squamous cell carcinoma.
    Pathol Int 2018 Feb 16. Epub 2018 Feb 16.
    Department of Diagnostic Pathology, Osaka Police Hospital.
    A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. Read More

    RRS1 gene expression involved in the progression of papillary thyroid carcinoma.
    Cancer Cell Int 2018 13;18:20. Epub 2018 Feb 13.
    1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
    Background: Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Despite an increasing body of evidences highlights ribosome biogenesis regulator homolog (RRS1) as a ribosome biogenesis protein in yeast and plants, little is known about human RRS1 function.

    Methods: Proliferation, cell cycle and apoptosis of PTC cells were assessed following the knockdown of RRS1 expression though MTT, colony formation assay, and flow cytometry. Read More

    Papillary thyroid carcinoma presenting as acute suppurative thyroiditis: A case report and review of the literature.
    Int J Pediatr Otorhinolaryngol 2018 Feb 5;105:12-15. Epub 2017 Dec 5.
    Department of Otolaryngology - Head and Neck Surgery, Children's Hospital of Richmond, Virginia Commonwealth University Health System, 1200 E Broad St, West Hospital, 12th Floor, South Wing, Suite 313, PO Box 980146, Richmond, VA 23298, United States. Electronic address:
    Acute suppurative thyroiditis is a rare, potentially life-threatening condition. We report the case of a 17-year-old male who initially presented with a thyroid abscess. Due to persistent symptoms and lack of evidence for underlying predisposing factors, he was followed closely and subsequently diagnosed with papillary thyroid cancer. Read More

    Thyroid carcinoma producing β-human chorionic gonadotropin shows different clinical behavior.
    Pathol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology, Shandong University School of Basic Medical Sciences, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.
    Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. Read More

    Diagnostic Performance of Margin Features in Thyroid Nodules in Prediction of Malignancy.
    AJR Am J Roentgenol 2018 Feb 15:1-6. Epub 2018 Feb 15.
    3 Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr, H1307, Stanford, CA 94305.
    Objective: The purpose of this study was to evaluate thyroid nodule margins for specific morphologic features and determine the diagnostic performance of these features in differentiating papillary carcinoma from benign thyroid nodules.

    Materials And Methods: Nodules measuring 1-3 cm in largest diameter that had been evaluated with high-resolution ultrasound (12-18 MHz) and ultrasound-guided biopsy with definitive pathologic diagnosis were analyzed. Three blinded board-certified readers evaluated high-resolution images of each nodule for jagged edges, lobulated borders, and curved borders along their margins. Read More

    Risk of recurrence in a homogeneously managed pT3-differentiated thyroid carcinoma population.
    Langenbecks Arch Surg 2018 Feb 14. Epub 2018 Feb 14.
    Department of General, Visceral, and Endocrine Surgery, Pitié Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France.
    Background: International guidelines for the management of differentiated thyroid cancers are based on the 7th TNM classification: pT3 tumors are defined as differentiated thyroid cancers (DTCs) measuring more than 4 cm in their greatest dimension that are limited to the thyroid or any tumor with minimal extrathyroidal extension (ETE; sternothyroid muscle or perithyroid soft tissues). Differences in clinicohistological features and prognosis among patients with pT3 tumors remain controversial, and studies regarding pT3 subgroups are lacking.

    Objective: To analyze the prognosis of four subgroups of pT3 DTCs (papillary, PTC; or follicular, FTC). Read More

    Role of thyroid ultrasound combined with thyroglobulin in the diagnosis of postoperative recurrence of thyroid cancer.
    Minerva Endocrinol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Ultrasonography, Lihuili East Hospital, Ningbo Medical Center, Ningbo, China -
    Background: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice.

    Methods: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed. Read More

    Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma.
    World J Surg Oncol 2018 Feb 13;16(1):30. Epub 2018 Feb 13.
    Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Full address: 1 Friendship Road, Yu Zhong District, Chongqing, 400016, China.
    Background: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. Read More

    A nomogram based on the characteristics of metastatic lymph nodes to predict papillary thyroid carcinoma recurrence.
    Thyroid 2018 Feb 14. Epub 2018 Feb 14.
    West China Hospital of Sichuan University, Chengdu, Sichuan, China ;
    Background And Aims: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk.

    Patients And Methods: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study. Read More

    BRAF and RAS mutational status in non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma in Korea.
    Thyroid 2018 Feb 14. Epub 2018 Feb 14.
    Asan Medical Center, University of Ulsan College of Medicine, Pathology, Seoul, Korea (the Republic of) ;
    Background: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor previously known as non-invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). The absence of BRAFV600E mutations has been considered characteristic of NIFTPs. However, a recent study from Korea found that 28. Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Endocr Relat Cancer 2018 Feb 9. Epub 2018 Feb 9.
    M Sobrinho-Simões, Patologia, Centro Hospitalar de Sao Joao EPE, Porto, Portugal
    The 2017 edition of the WHO book on Classification of Tumours of Endocrine Organs includes a new section entitled "Other encapsulated follicular-patterned thyroid tumours", in which the newly created NIFTP (Non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is identified and detailed described. Despite deleting the word "carcinoma" from its name, NIFTP is not a benign tumor either, and is best regarded as a neoplasm with "very low malignant potential". The main goal of the introduction of NIFTP category is to prevent overdiagnosis and overtreatment. Read More

    Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort.
    J Clin Endocrinol Metab 2018 Feb 8. Epub 2018 Feb 8.
    Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA.
    Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease.

    Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort.

    Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015. Read More

    LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer.
    Int J Oncol 2018 Feb 9. Epub 2018 Feb 9.
    Oncology Research Laboratory, Department of Radiation Sciences, Umeå University, SE-90187 Umeå, Sweden.
    Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1 expression levels are associated with patient survival in many cancer types. Read More

    The rising trend in papillary thyroid carcinoma. True increase or over diagnosis?
    Saudi Med J 2018 Feb;39(2):147-153
    Department of Histopathology, Microbiology and Forensic Medicine, University of Jordan, Amman, Jordan. E-mail.
    Objectives: To assess the changes in parameters of thyroid carcinoma, particularly papillary type, in the era of widespread use of sensitive diagnostic methods. We aim to investigate whether the increased frequency of thyroid cancer is true or resulted from over diagnosis. Methods: We conducted a retrospective study of 313 cases of thyroid carcinoma diagnosed at Jordan University Hospital and King Hussein Cancer Center from 2007-2015. Read More

    Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma.
    Biomed Res Int 2017 25;2017:8701386. Epub 2017 Dec 25.
    Department of Morphofunctional Sciences I-Histology, Pathology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Background: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors.

    Aim: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors.

    Material And Methods: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. Read More

    miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis.
    Oncotarget 2018 Jan 29;9(4):5473-5479. Epub 2017 Mar 29.
    Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
    Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. Read More

    TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases.
    Oncol Lett 2018 Mar 21;15(3):2763-2770. Epub 2017 Dec 21.
    Department of Surgical Pathology, University Hospital of Pisa, I-56126 Pisa, Italy.
    Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy and accounts for ~80% of thyroid carcinomas in adults and 90% in children. Risk stratification is important for identifying patients at higher risk and, for this reason, recent advances in molecular genetics of thyroid cancer can be applied to provide novel biomarkers useful in understanding tumor behavior. B-Raf proto-oncogene, serine/threonine kinase (BRAF) and rat sarcoma (RAS) mutations have been widely studied and appear to have an important role in thyroid tumorigenesis. Read More

    Squamous differentiation in papillary thyroid carcinoma: a rare feature of aggressive disease.
    J Surg Res 2018 Mar 9;223:39-45. Epub 2017 Nov 9.
    Department of Surgery, University of California, San Francisco, San Francisco, California. Electronic address:
    Background: Papillary thyroid carcinoma with squamous differentiation (PTC-SD) is a poorly understood pathologic finding of unknown clinical significance. Selected case reports have suggested that PTC-SD is an aggressive tumor with a poor prognosis. Here we present the largest case series of PTC-SD reported in the United States. Read More

    Rare Case of Intratracheal Metastasis Detected on 68Ga-Prostate-Specific Membrane Antigen PET/CT Scan in a Case of Thyroglobulin Elevated Negative Iodine Scan Syndrome.
    Clin Nucl Med 2018 Feb 9. Epub 2018 Feb 9.
    A 64-year-old woman underwent completion thyroidectomy with upper tracheal ring resection and right-sided neck dissection for papillary carcinoma of the thyroid infiltrating the trachea and was given I radioiodine treatment. Three years later, she presented with hemoptysis. On evaluation, she had increased serum thyroglobulin and negative iodine scan (TENIS). Read More

    Preoperative Cytologic Diagnosis of Warthin-like Tumor Variant of Papillary Thyroid Carcinoma.
    J Pathol Transl Med 2018 Feb 12. Epub 2018 Feb 12.
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution. Read More

    [Evaluation of central lymph node dissection for papillary thyroid carcinoma in cN0 T1/T2].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Feb;53(2):105-109
    Department of Thyroid Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
    To evaluate the application of the central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) in cN0 T1/T2.Retrospective analysis of 532 cases with PTC in cN0 T1/T2 who underwent CLND between October 2014 and September 2016 in the Department of Thyroid Surgery, the First Affiliated Hospital of the Kunming Medical University. The incidence of central lymph node (CLN) metastasis and risk factors were analyzed. Read More

    The Sonographic Subcentimeter Malignant Thyroid Nodule: What Does It Stand for?
    Am Surg 2018 Jan;84(1):137-139
    Thyroid cancer management has moved to less extensive surgery in lesions with favorable criteria. Our study evaluated if the sonographic (US) size of thyroid nodules is a reliable criterion to determine the extent of surgery in patients with papillary thyroid carcinoma (PTC). A retrospective study was performed to evaluate thyroid nodules measuring <10 mm in the preop sonogram with a permanent pathology of PTC. Read More

    miR-199a-5p inhibits the progression of papillary thyroid carcinoma by targeting SNAI1.
    Biochem Biophys Res Commun 2018 Feb 8. Epub 2018 Feb 8.
    Department of General Surgery, Longnan Hospital of Daqing, Heilongjiang, 163453, China. Electronic address:
    Background: Increasing evidence has emphasized the important roles of differentially expressed miRNAs in papillary thyroid cancer (PTC) development. miR-199a-5p was previously documented to be downregulated in PTCs compared with normal thyroids. However, the role of miR-199a-5p in the progression of PTC and the underlying mechanism remain to be further addressed. Read More

    Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature.
    J Pediatr Endocrinol Metab 2018 Feb 10. Epub 2018 Feb 10.
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
    Background: There have been great concerns about pediatric thyroid cancers after the accident at the Fukushima Daiichi Nuclear Power Plant in 2011.

    Case Presentation: We report a case of a 7-year-old Japanese girl with sporadic papillary thyroid carcinoma (PTC) harboring an ETV6/NTRK3 rearrangement. The patient presented with tumors in both lobes and underwent thyroidectomy followed by radioactive iodine (RAI) ablation. Read More

    Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study.
    J Cancer Res Clin Oncol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, China.
    Purpose: To evaluate the safety and efficacy of ultrasound-guided low-power microwave ablation (MWA) for the treatment of papillary thyroid microcarcinoma (PTMC) with a 3-year follow-up.

    Methods: A total of 21 nodules diagnosed as PTMC from the 15 patients were performed with MWA at a power of 20 W. The images of the nodules were recorded by ultrasound before MWA and 1, 3, 6, 12 months after MWA, and every 6 months thereafter, respectively. Read More

    The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the rate of malignancy for atypia of undetermined significance subcategories.
    Cancer Cytopathol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
    Background: The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine-needle aspiration (FNA) cytology.

    Methods: Consecutive thyroid FNAs interpreted as AUS over a period of 4 years were retrospectively analyzed. Read More

    Clinico-pathological and prognostic findings on 27 cases of medullary thyroid carcinoma.
    Tunis Med 2017 Feb;95(2):97-102
    Introduction: Medullary thyroid carcinoma is a rare tumor accounting for less than 10% of thyroid neoplasm. This tumor is characterized by important histological polymorphism which makes morphological diagnosis difficult and immunohistochemical study often necessary.

    Objective: We aim to perform a retrospective review of clinical and pathological characteristics of medullary carcinoma. Read More

    Incidental thyroid carcinoma in patients with TIR1, TIR2 and TIR3 FNA.
    Ann Ital Chir 2018 Feb 9;7. Epub 2018 Feb 9.
    Aim: The aim of our study was to evaluate the presence of incidental differentiated thyroid carcinomas, at final histological examination, in patients undergoing thyroidectomy or lobectomy for presumed benign pathology or in those with cytological diagnosis of indeterminate nodules (TIR3).

    Material Of Study: 457 patients who underwent surgery for benign disease and 179 patients with indeterminate FNA were included in our study.

    Results: 77 out of 457 patients had the diagnosis of differentiated thyroid carcinoma. Read More

    Clinicopathological significance of chemokine receptor CXCR4 expression in papillary thyroid carcinoma: a meta-analysis.
    Minerva Endocrinol 2018 Feb 8. Epub 2018 Feb 8.
    Department of General Surgery, Nanjing Hospital of Traditional Chinese Medicine, No.3 Affiliated Hospital of Nanjing, University of Chinese Medicine, Nanjing, Jiangsu, P.R China -
    Introduction: Emerging evidence indicates that C-X-C chemokine receptor type 4(CXCR 4) is a candidate oncogene in several types of human tumors including papillary thyroid carcinoma (PTC). To investigate its expression impact on clinicopathological features, a meta-analysis was performed.

    Evidence Acquisition: A comprehensive search in the PubMed, Embase and The Cochrane Library (up to March 14, 2017) was performed for relevant studies using multiple search strategies. Read More

    LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by sponging miR-222-3p in papillary thyroid carcinoma.
    Oncotarget 2018 Jan 16;9(3):3519-3530. Epub 2017 Dec 16.
    Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
    Accumulating evidence demonstrates that the long non-coding RNA Growth Arrest-Specific 5 (Gas5) has practical significance in cancer progression and metastasis. However, its role and function in papillary thyroid carcinoma (PTC) remains unknown. In this study, we aimed to explore the potential involvement of Gas5 in papillary thyroid carcinogenesis and to highlight the emerging roles of ceRNAs in the biological regulation of PTC cells. Read More

    The presence of papillary features in thyroid nodules diagnosed as atypia of undetermined significance or follicular lesion of undetermined significance increases cancer risk and should influence treatment.
    Am J Surg 2018 Jan 5. Epub 2018 Jan 5.
    Department of Surgery, St. Paul's Hospital & University of British Columbia, Vancouver, BC, Canada. Electronic address:
    Background: The objective of this study was to evaluate the influence of papillary features on risk of malignancy (ROM) within the Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance (AUS-FLUS) Bethesda System for Reporting Thyroid Cytopathology (BSRTC) diagnostic category.

    Methods: A Retrospective review of cases with an AUS-FLUS diagnosis that underwent a thyroidectomy was carried out, and cases were subcategorized based upon the presence of papillary features.

    Results: For the entire study population there were 93 (22%) of 427 FNAB specimens that had an AUS-FLUS diagnosis, and a 32% associated ROM. Read More

    Synchronous papillary thyroid cancer and non-Hodgkin lymphoma: Case report.
    Medicine (Baltimore) 2018 Feb;97(6):e9831
    General and Surgical Oncology Division, University of Perugia, Perugia, Italy.
    Rationale: Differentiated thyroid cancer is the most common endocrine malignancy with concomitant hematological malignancy in 7%.

    Patient Concerns: We present a case of a synchronous papillary thyroid cancer and a follicular variant of non-Hodgkin lymphoma and discuss the possible diagnostic and treatment dilemmas.

    Diagnosis: A 48-year-old female was reffered to our hospital with diagnosis "thyroid cancer". Read More

    Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?
    Oncotarget 2018 Jan 20;9(2):2445-2467. Epub 2017 Dec 20.
    Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for PTC development. The CXCR3-ligand system is involved in thyroid inflammation and CXCR3 has been found upregulated in many tumors, suggesting its pro-tumorigenic role under the inflammatory microenvironment. Read More

    CUNR scoring system for the prediction of lateral lymph node metastasis in papillary thyroid carcinoma.
    Oncotarget 2018 Jan 30;9(1):167-177. Epub 2017 Nov 30.
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Objective: Our present study aimed to evaluate and compare the number and rate of central lymph node metastases (LNMs) for the prediction of lateral LNM (LLNM) in papillary thyroid carcinoma (PTC) and to develop a scoring system.

    Results: Capsule invasion, tumor location in the upper portion of the thyroid, an ipsilateral central compartment LNM number ≥3, and an ipsilateral central compartment LNM rate of ≥56% were identified as significant independent predictors of ipsilateral lateral LNM in PTC. The predictive ability of an ipsilateral central compartment LNM rate ≥56% (area under the curve (AUC) = 0. Read More

    Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens.
    Ann Diagn Pathol 2018 Feb 18;32:35-40. Epub 2017 Sep 18.
    Department of Pathology, Gachon University Gil Medical Center, Incheon, Republic of Korea. Electronic address:
    Background: Core needle biopsy (CNB) has been used as an alternative or a complementary method for diagnosis of thyroid nodules. However, morphological analysis of the nuclear features of papillary thyroid carcinoma (PTC) cells obtained via CNB remains unclear. Hence, we examined the differences between the PTC nuclear features in CNB and thyroidectomy specimens. Read More

    Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis.
    Arch Endocrinol Metab 2017 Dec;61(6):643-646
    Department of Biomedical Sciences and Morphological and Functional Images, Unit of Nuclear Medicine, University of Messina, Messina, Italy.
    Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Read More

    Thyroglobulin levels before radioactive iodine therapy and dynamic risk stratification after 1 year in patients with differentiated thyroid cancer.
    Arch Endocrinol Metab 2017 Dec;61(6):590-599
    Serviço de Endocrinología, Departamento de Medicina, Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP), São Paulo, SP Brasil.
    Objectives: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of response to therapy in these patients. A retrospective chart review of patients with differentiated thyroid cancer (DTC) who underwent RIT after surgery and were followed for at least 1 year, was carried out.

    Subjects And Methods: Patients were classified according to the dynamic risk stratification 1 year after initial treatment. Read More

    HMGA2 Gene Expression in Fine-needle Aspiration Samples of Thyroid Nodules as a Marker for Preoperative Diagnosis of Thyroid Cancer.
    Appl Immunohistochem Mol Morphol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
    There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction. Read More

    Galectin-3 and HBME-1 Expression on Agarose Cell Blocks from Fine-needle aspirates of Follicular Cell-derived Thyroid Tumors.
    J Cytol 2018 Jan-Mar;35(1):27-32
    Department of Pathology, Faculty of Medicine, Cairo University, Egypt.
    Aim: To test the expression of galectin-3 (gal-3) and Hector Battifora mesothelial antigen-1 (HBME-1) on agarose cell blocks (CBs) of fine-needle aspirates aiming to determine their diagnostic value in thyroid follicle cell-derived tumors.

    Materials And Methods: Forty patients with thyroid nodule were enrolled. Fine-needle aspiration biopsy was done and processed to produce smears and CBs. Read More

    Temporal Trends in the Presentation, Treatment, and Outcome of Medullary Thyroid Carcinoma - An Israeli Multicenter Study.
    Thyroid 2018 Feb 5. Epub 2018 Feb 5.
    Hadassah-Hebrew University Medical Center, Neuroendocrine Tumor Unit, Endocrinology & Metabolism Service , P.O.B. 12000, Jerusalem , Jerusalem, Israel , 91120 ;
    Background: The widespread use of neck sonography in recent years has led to a dramatic increase in the detection of thyroid cancer, accompanied by changes in the clinicopathological features of the disease. However, small papillary carcinomas account for the bulk of this increase, while little is known about temporal changes in medullary thyroid carcinoma (MTC). The aim of this study was to evaluate trends in the presentation, treatment, and outcome of MTC. Read More

    MicroRNA-144 inhibits proliferation by targeting WW domain-containing transcription regulator protein 1 in papillary thyroid cancer.
    Oncol Lett 2018 Jan 17;15(1):1007-1013. Epub 2017 Nov 17.
    Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
    Papillary thyroid carcinoma (PTC), the most common histological subtype of thyroid cancer, accounts for between 80 and 90% of all thyroid cancer cases. Previous studies have suggested that microRNAs (miRNAs/miRs) are involved in the development of PTC. The aim of the present study was to investigate whether miR-144 inhibits cellular proliferation in PTC. Read More

    Stimulated Serum Thyroglobulin Levels versus Unstimulated Serum Thyroglobulin in the Follow-up of Patients with Papillary Thyroid Carcinoma.
    World J Nucl Med 2018 Jan-Mar;17(1):41-45
    Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
    Serum thyroglobulin (Tg) and thyroid whole-body radioiodine scintigraphy (TWBS) are used in the follow-up of patients with papillary thyroid carcinoma (PTC) after total thyroidectomy. Symptoms of hypothyroidism are frequent as patients discontinue levothyroxine 1 month before visit, favoring the use of unstimulated serum Tg (uSTg) only. This study was done to determine the reliability of stimulated serum Tg levels (sSTg) over uSTg. Read More

    Papillary Carcinoma of Thyroid with Nasal Cavity Metastases: A Case Report.
    Iran J Med Sci 2018 Jan;43(1):90-93
    Department of Ear, Nose, Throat, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
    Papillary thyroid carcinoma (PTC) is one of the most commonly diagnosed types of differentiated carcinoma of the thyroid. It is stated that lung is the most common site of metastasis followed by bone. The incidence of paranasal sinus (PNS) metastasis is fairly uncommon in case of thyroid carcinoma. Read More

    1 OF 331