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    VARIABILITY IN THYROID CANCER MANAGEMENT AND PROGNOSIS AMONG HISPANIC VERSUS NON-HISPANIC PATIENTS : 17 YEARS DATA FROM UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AND UNIVERSITY HEALTH SYSTEM AT SAN ANTONIO.
    Endocr Pract 2017 Aug 17. Epub 2017 Aug 17.
    Endocrinology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill-Cornell College of Medicine, New York, NY.
    Abstracts: Objective : Given the increase in the incidence of thyroid cancer in the United States, and it's potential public health implications, patient studies assessing ethnic, disparity and health care access are important. In this study, we retrospectively examined the variability in stage of thyroid cancer at presentation and final outcome among Hispanic vs non-Hispanic patients.

    Method: After obtaining IRB approval, we retrospectively reviewed the medical records of 220 adult patients with papillary thyroid carcinoma(PTC) who were treated at UT Health Science Center San Antonio between1996 and 2013. Read More

    Synchronous malignancies of thyroglossal duct cyst and thyroid gland.
    Natl Med J India 2017 Mar-Apr;30(2):76-77
    Radiation Medicine Centre (Bhabha Atomic Research Centre), Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra 400012; Homi Bhabha National Institute, Mumbai, Maharashtra, India.
    Malignant involvement of thyroglossal duct cyst is rare, still rarer is the synchronous malignant involvement of the thyroid gland. Although the Sistrunk procedure is often regarded as adequate, controversy exists of the need for an additional total thyroidectomy and radioiodine ablative therapy, the decision of which depends upon the presence of (i) suspicious thyroid gland nodule; (ii) presence of lymphadenopathy; or (iii) a previous history of neck irradiation. We report a 47-year-old woman diagnosed with papillary carcinoma within a recurrent thyroglossal duct cyst with infiltration into surrounding soft tissues and a suspicious thyroid nodule of the left thyroid lobe with no regional lymph node involvement. Read More

    A study of Galactin-3 on fine needle aspiration as a diagnostic marker differentiating benign from malignant thyroid neoplasm.
    Pak J Med Sci 2017 May-Jun;33(3):726-731
    Prof. Dr. Ihtesham uddin Qureshi, MBBS, M.Phil. Professor of Pathology, Postgraduate Medical Institute, Lahore, Pakistan.
    Background & Objective: Thyroid nodules are very common in our setup and their diagnosis on fine needle aspiration is not easy and is a taxing affair. It is a challenge to differentiate between follicular adenoma and follicular carcinoma without histology. Our objective was to investigate the role of Galectin-3 in fine needle aspirates of thyroid nodules as a prospective diagnostic marker and consequently its ability to differentiate benign from malignant neoplasms. Read More

    Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma.
    Pathobiology 2017 Aug 16. Epub 2017 Aug 16.
    Department of Clinical Laboratory, Kuma Hospital, Kobe, Japan.
    Objective: The purpose of this study was to clarify the diagnostic significance of cytoplasmic lipid accumulation (CLIA) in the cribriform variant of papillary thyroid carcinoma (CV-PTC).

    Methods: We performed a histological, immunohistochemical, and cytological examination of 35 CV-PTC cases at the Kuma Hospital. CLIA was defined as bubble-like multivacuolation in cytoplasm with distinct cell border. Read More

    Relationship Between (18)F-fluorodeoxyglucose Accumulation and the BRAF (V600E) Mutation in Papillary Thyroid Cancer.
    World J Surg 2017 Aug 14. Epub 2017 Aug 14.
    Department of Otolaryngology-Head and Neck Surgery, Research Institute for Medical Science, College of Medicine, Chungnam National University, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-721, Republic of Korea.
    Background: To determine whether (18)F-fluoro-2-deoxyglucose ((18)F-FDG)-PET/CT is useful for predicting the BRAF (V600E) mutation status of a primary papillary thyroid carcinoma (PTC).

    Methods: A retrospective analysis was performed in 108 patients who underwent (18)F-FDG positron emission tomography-computed tomography (PET/CT) for staging before thyroidectomy and BRAF analysis in biopsy-confirmed PTC. The maximum standardized uptake value (SUVmax) of the primary tumor was calculated according to FDG accumulation. Read More

    Evaluating the effectiveness of prophylactic central neck dissection with total thyroidectomy for cN0 papillary thyroid carcinoma: An update meta-analysis.
    Eur J Surg Oncol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, PR China. Electronic address:
    Background: The effectiveness of prophylactic central neck dissection (pCND) following total thyroidectomy (TT) in patients with clinical node-negative (cN0) papillary thyroid carcinoma (PTC) is still controversial. The aim of the meta-analysis is to evaluate the outcome of pCND and provide quantitative evidence.

    Method: A detailed literature search of PubMed, EMBASE, ClinicalTrails. Read More

    Role of Contrast-Enhanced Ultrasound in the Pre-operative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma.
    Ultrasound Med Biol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Ultrasound, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou City, Zhejiang Province, China. Electronic address:
    The objective of this study was to prospectively evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiating between benign and metastatic cervical lymph nodes in patients with papillary thyroid cancer (PTC). Three hundred nineteen cervical lymph nodes (162 metastatic from PTC and 157 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Metastatic lymph nodes more often manifested centripetal or asynchronous perfusion, hyper-enhancement, heterogeneous enhancement, perfusion defects and ring-enhancing margins than benign lymph nodes at pre-operative CEUS (all p values < 0. Read More

    A potential role for the Hippo pathway protein, YAP, in controlling proliferation, cell cycle progression, and autophagy in BCPAP and KI thyroid papillary carcinoma cells.
    Am J Transl Res 2017 15;9(7):3212-3223. Epub 2017 Jul 15.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430022, China.
    Purpose: The aims were two-fold: first, to examine the expression of Yes-activated protein (YAP), a key Hippo pathway regulator, in clinical thyroid papillary carcinoma samples and to correlate this with clinicopathological parameters; second, to explore the role of YAP in regulating cell growth and division in vitro.

    Methods And Results: YAP expression was determined by immunohistochemistry of clinical thyroid papillary carcinoma tissue microarrays and expression was correlated with clinicopathological parameters. YAP expression positively correlated with TNM stage and lymph node metastasis. Read More

    Patients with Non-invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features are Unlikely to have Malignant Preoperative Cytology.
    Ann Surg Oncol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.
    Background: The newly termed tumor 'noninvasive follicular thyroid neoplasm with papillary-like nuclear features' (NIFTP) acts in an indolent manner and can likely be safely managed with a thyroid lobectomy. Preoperative fine-needle aspiration (FNA) is the cornerstone of surgical planning, but the ability of FNA to distinguish NIFTP from other variants of papillary thyroid carcinoma (PTC) has not been well-evaluated.

    Methods: A 9-year retrospective review of the preoperative cytology and surgical pathology of PTC patients who underwent a thyroidectomy at our tertiary referral center. Read More

    Ethanol and thermal ablation for malignant thyroid tumours.
    Int J Hyperthermia 2017 Aug 11:1-8. Epub 2017 Aug 11.
    a Department of Radiology and Research Institute of Radiology , University of Ulsan College of Medicine, Asan Medical Center , Seoul , Korea.
    Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid malignancy and has a good prognosis and low mortality rate. Surgery is the standard treatment for patients with primary and recurrent thyroid cancer. Although patients with PTC usually exhibit excellent treatment outcome, the incidence of recurrence in the neck ranges from 20% to 59%. Read More

    Papillary thyroid carcinoma with desmoid-type fibromatosis: A clinical, pathological, and immunohistochemical study of 14 cases.
    Endocr J 2017 Aug 10. Epub 2017 Aug 10.
    Department of Surgery, Kuma Hospital, Kobe, Kuma Hospital, Japan.
    Papillary thyroid carcinoma (PTC) with desmoid-type fibromatosis (DTF) is characterized by genetic alterations of the fibroblasts. However, PTC-DTF is extremely rare, and the reports on such cases have been sporadic. Immunohistochemical staining using the antibody for beta-catenin is useful in diagnosing the variant. Read More

    Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine.
    Endocr J 2017 Aug 10. Epub 2017 Aug 10.
    Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.
    This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series. On multivariate comparison, the Japanese pediatric PTC was characterized by a higher sex ratio (p=1. Read More

    [Related factors on skip metastasis of neck lymph node in papillary thyroid carcinoma].
    Zhonghua Wai Ke Za Zhi 2017 Aug;55(8):599-602
    Department of Thyroid Surgery, the First Hospital of Jilin University, Changchun 130021, China.
    Objective: To investigate the correlation between skip metastasis of neck lymph node and clinicopathological features in papillary thyroid carcinoma. Methods: Totally 272 papillary thyroid carcinoma patients with lateral lymph node metastases who received surgical procedure at Department of Thyroid Surgery, the First Hospital of the Jilin University from January 2014 to June 2016 were analyzed retrospectively. There were 105 male and 167 female patients, aging from 16 to 73 years with a mean age of (42±8) years. Read More

    [Related factors analysis for lymph node metastasis in papillary thyroid carcinoma: a series of 2 073 patients].
    Zhonghua Wai Ke Za Zhi 2017 Aug;55(8):592-598
    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
    Objective: To investigate the related factors for lymph node metastasis (LNM), especially for high volume LNM (>5 metastatic lymph nodes) in papillary thyroid carcinoma (PTC). Methods: The medical records of 2 073 consecutive PTC patients who underwent lobectomy, near-total thyroidectomy or total thyroidectomy with ipsilateral or bilateral central lymph node dissection in Department of General Surgery, Peking Union Medical College Hospital from November 2013 to October 2014 were reviewed. Clinical and pathological features were collected. Read More

    [Preliminary experience with transoral endoscopic thyroidectomy via vestibular approach: a report of 150 cases in a single center].
    Zhonghua Wai Ke Za Zhi 2017 Aug;55(8):587-591
    Department of Thyroid Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
    Objective: To summarize the preliminary experience with transoral endoscopic thyroidectomy via vestibular approach (TOETVA). Methods: A total of 150 consecutive patients with thyroid disease underwent TOETVA from November 2014 to February 2017 at Department of Thyroid Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine. The patients were comprised of 138 females and 12 males. Read More

    Association between the BRAF V600E mutation and ultrasound features of the thyroid in thyroid papillary carcinoma.
    Oncol Lett 2017 Aug 29;14(2):1439-1444. Epub 2017 May 29.
    Department of Medical Ultrasonics, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, P.R. China.
    The aim of the present study was to investigate the association between the BRAF V600E mutation and ultrasound features of the thyroid in papillary thyroid carcinoma (PTC). Fresh thyroid carcinoma tissue and paracarcinoma tissue were obtained from 34 patients undergoing surgery for PTC. The BRAF V600E mutation was detected by PCR amplification and direct DNA sequencing. Read More

    In situ preservation of the inferior parathyroid gland during central neck dissection for papillary thyroid carcinoma.
    Br J Surg 2017 Aug 7. Epub 2017 Aug 7.
    Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Background: Postoperative hypocalcaemia due to dysfunction of the parathyroid glands is the most common complication after total thyroidectomy plus central neck dissection (CND). There is a lack of surgical techniques described to help preserve the inferior parathyroid gland in situ during CND. The objective of this study was to introduce the 'TBP layer' (layer of thymus-blood vessel-inferior parathyroid gland) concept for preserving the inferior parathyroid gland in situ during CND, and to evaluate its effectiveness. Read More

    Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients.
    Int J Endocrinol 2017 11;2017:2645904. Epub 2017 Jul 11.
    Department of Medical Genetics and Developmental Biology, Capital Medical University, Beijing 100069, China.
    Background: Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown.

    Materials And Methods: We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction. Read More

    Accounting for tissue heterogeneity in infrared spectroscopic imaging for accurate diagnosis of thyroid carcinoma subtypes.
    Vib Spectrosc 2017 Jul 16;91:77-82. Epub 2016 Sep 16.
    Department of Pathology, University of Illinois at Chicago, 840 S Wood St. 130 CSN, Chicago, IL 60612, USA.
    Fourier transform infrared (FT-IR) microscopy was used to image tissue samples from twenty patients diagnosed with thyroid carcinoma. The spectral data were then used to differentiate between follicular thyroid carcinoma and follicular variant of papillary thyroid carcinoma using principle component analysis coupled with linear discriminant analysis and a Naïve Bayesian classifier operating on a set of computed spectral metrics. Classification of patients' disease type was accomplished by using average spectra from a wide region containing follicular cells, colloid, and fibrosis; however, classification of disease state at the pixel level was only possible when the extracted spectra were limited to follicular epithelial cells in the samples, excluding the relatively uninformative areas of fibrosis. Read More

    Letter regarding the article: "Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls" by Kern et al.
    Eur J Med Genet 2017 Aug 2. Epub 2017 Aug 2.
    Division of Endocrine and Metabolic Diseases, Istituto Auxologico IRCCS, Milan, Italy.
    This Journal recently published a study (Kern et al., 2017) reporting the genetic analysis of the whole HABP2 gene in 11 independent kindreds with familial non medullary thyroid cancer (FNMTC). The Authors showed that a new variant (p. Read More

    Macrometastasis in Papillary Thyroid Cancer Patients is Associated with Higher Recurrence in Lateral Neck Nodes.
    World J Surg 2017 Aug 4. Epub 2017 Aug 4.
    Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul, 135-720, Republic of Korea.
    Background: The use of routine central compartment neck dissection surgery for papillary thyroid carcinoma (PTC) is controversial. Although macroscopic central neck lymph node metastasis (CNLN) in PTC is a poor prognostic factor correlated with increased loco-regional recurrence, the significance of microscopic metastasis to the central lymph nodes is not established. Herein, we aimed to assess the influence of the size of CNLN on disease recurrence among PTC patients. Read More

    The Molecular Landscape of Noninvasive Follicular Thyroid Neoplasm With Papillary-like Nuclear Features (NIFTP): A Literature Review.
    Adv Anat Pathol 2017 Sep;24(5):252-258
    *Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa †Unit of Pathological Anatomy, 3rd Division, University Hospital of Pisa, Pisa, Italy ‡Department of Pathology, Queen Alexandra Hospital, University of Portsmouth, Portsmouth, UK §Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA.
    The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding overtreatment of patients with NIFTP lesions who in the past were diagnosed with thyroid carcinoma and typically received completion thyroidectomy followed by radioactive iodine ablation. Read More

    Thyrospheres from B-CPAP Cell Line with BRAF and TERT Promoter Mutations have Different Functional and Molecular Features than Parental Cells.
    J Cancer 2017 3;8(9):1629-1639. Epub 2017 Jun 3.
    Department of Biomedical Sciences, University of Cagliari, Italy.
    Human thyroid cancer derived cell lines are widely used to study the mechanisms involved in thyroid carcinogenesis. However, there is limited availability of non-cross-contaminated cancer cell lines derived from papillary thyroid carcinoma (PTC), and the B-CPAP cell line is one of the few such lines. B-CPAP cells have been genetically and cytogenetically well-characterized, but details of their stemness features remain uncertain. Read More

    An Indian Tertiary Care Hospital Scenario of Papillary Carcinoma of Thyroid.
    J Clin Diagn Res 2017 Jun 1;11(6):EC26-EC29. Epub 2017 Jun 1.
    Clinical Research Scholar, Department of Division of Pulmonary and Critical Care Medicine, Emory University, School of Medicine, Atlanta, GA, USA.
    Introduction: Thyroid carcinoma is the most common endocrine malignancy and its Papillary Histotype {Papillary Carcinoma of Thyroid (PTC)} is the most common type of Thyroid cancer. The clinicopathological features of PTC vary with geographical location.

    Aim: To describe the clinicopathological profile of PTC in a Tertiary Care Hospital located in Chennai, Tamil Nadu, India. Read More

    The role of microRNAs in different types of thyroid carcinoma: a comprehensive analysis to find new miRNA supplementary therapies.
    J Endocrinol Invest 2017 Jul 31. Epub 2017 Jul 31.
    Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    The most common endocrine malignancy is thyroid cancer, and researchers have made a great deal of progress in deciphering its molecular mechanisms in the recent years. Many of molecular changes observed in thyroid cancer can be used as biomarkers for diagnosis, prognosis, and therapeutic targets for treatment. MicroRNAs (miRNAs) are important parts in biological and metabolic pathways such as regulation of developmental stages, signal transduction, cell maintenance, and differentiation. Read More

    Adequate sampling of multiple thyroid nodules by fine-needle aspiration.
    Cancer 2017 Jul 31. Epub 2017 Jul 31.
    Department of Pathology, Baptist Hospital and Miami Cancer Institute, Miami, Florida.
    Background: Recommendations regarding how many nodules to biopsy with thyroid fine-needle aspiration vary.

    Methods: The authors reviewed fine-needle aspiration specimens of 12,763 nodules from 10,506 patients and correlated them with the number of nodules biopsied.

    Results: Compared with patients in whom only a single nodule was biopsied, patients in whom multiple nodules were biopsied were found to be significantly younger, more likely female, and to have larger tumors, and those tumors were more often papillary (all P<. Read More

    A distinct serum metabolic signature of distant metastatic papillary thyroid carcinoma.
    Clin Endocrinol (Oxf) 2017 Jul 29. Epub 2017 Jul 29.
    Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
    Background: Although the incidence rate for thyroid cancer seems to have begun stabilizing in recent years, an increased rate of advanced stage of this disease has been reported. Additionally, distant metastasis is one of the most important prognostic factors of patients with papillary thyroid carcinoma (PTC). Unfortunately, the underlying mechanisms of distant metastasis as well as cell status like metabolism changes in distant metastatic tumors have not been clearly elucidated. Read More

    Circulating levels of PTEN and KLLN in papillary thyroid carcinoma: can they be considered as novel diagnostic biomarkers?
    Endocrine 2017 Jul 28. Epub 2017 Jul 28.
    Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: PTEN and KLLN are two tumor suppressor genes located in 10q23, share a bidirectional promoter and have roles in carcinogenesis. Formerly, the role of PTEN mutations and KLLN epimutations were identified in incidence of thyroid lesions in individuals with Cowden syndrome, a rare autosomal dominant inherited disorder. This study is the first of its type to assess PTEN and KLLN circulating levels in patients with sporadic papillary thyroid carcinoma (PTC) and compare to patients with multinodular goiter (MNG) and healthy individuals. Read More

    Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases.
    Sci Rep 2017 Jul 27;7(1):6670. Epub 2017 Jul 27.
    Departments of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.
    Preoperative assessment of the cervical lymph node status is important in therapeutic schedule and further evaluations of prognosis for papillary thyroid carcinoma (PTC) patients. Our aim was to investigate the diagnostic values of conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) features and the expression of MMP-9 of PTC in predicting the cervical lymph node metastases (LNM). In total, 156 patients with PTC confirmed by surgical pathology were included. Read More

    The role of external beam radiation therapy in well-differentiated thyroid cancer.
    Expert Rev Anticancer Ther 2017 Aug 2:1-6. Epub 2017 Aug 2.
    a BC Cancer Agency , Vancouver , Canada.
    Introduction: This review article explores the use of external beam radiotherapy (EBRT) in well differentiated thyroid cancer. Areas covered: The published literature on EBRT for advanced pT4 disease and macroscopic unresectable disease to improve locoregional control is reviewed. EBRT techniques, volumes and doses are discussed in detail. Read More

    Comparison of Consecutive Results from Fine Needle Aspiration and Core Needle Biopsy in Thyroid Nodules.
    Endocr Pathol 2017 Jul 26. Epub 2017 Jul 26.
    Department of Radiology, Seoul National University College of Medicine, Bundang Hospital, Gyeonggi-Do, South Korea.
    There are papers suggesting the complementary role of core needle biopsy (CNB) in the diagnosis of thyroid nodules. By comparing the result of CNB and fine needle aspiration (FNA) cytology performed in consecutive cases of thyroid nodules, the role of CNB was evaluated. Retrospective reviews of 2131 FNA and 275 CNB which were performed as first-line biopsy for 2406 thyroid nodules in 2187 patients were performed. Read More

    Letter to the Editor: Reply to "Ultrasonography and cytology as predictors of noninvasive follicular thyroid (NIFTP) neoplasm with papillary-like nuclear features: importance of the differential diagnosis with the invasive encapsulated follicular variant of papillary thyroid cancer".
    Clin Endocrinol (Oxf) 2017 Jul 26. Epub 2017 Jul 26.
    Department of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
    As Dr. Rosario pointed out, it might be more useful to differentiate NIFTP from invasive encapsulated follicular variant of papillary thyroid carcinoma (iE-FVPTC), not from infiltrative FVPTC (I-FVPTC) in clinical setting since infiltrative FVPTCs show overt malignant US features more frequently. However, in the previous study, we attempted to describe the characteristic ultrasound (US) features and diagnostic method of NIFTP specifically. Read More

    Nomograms predicting disease-specific regional recurrence and distant recurrence of papillary thyroid carcinoma following partial or total thyroidectomy.
    Medicine (Baltimore) 2017 Jul;96(30):e7575
    aCollege of Medicine, Zhejiang University bDepartment of Head and Neck Surgery cMedical Record Department, Zhejiang Cancer Hospital dZhejiang Chinese Medical University eDepartment of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
    The study aimed to establish effective nomograms for prediction of tumor regional recurrence and distant recurrence of papillary thyroid carcinoma (PTC) patients after partial or total thyroidectomy.These nomograms were based on a retrospective study on 1034 patients who underwent partial or total thyroidectomy for PTC. The predictive accuracy and discriminative ability of the nomograms were evaluated by the concordance index (C-index) and calibration curve. Read More

    Radioactive Iodine Ablation Decrease Recurrences in Papillary Thyroid Microcarcinoma with Lateral Lymph Node Metastasis in Chinese Patients.
    World J Surg 2017 Jul 24. Epub 2017 Jul 24.
    Department of Thyroid Surgery, The 1st Hospital of Jilin University, Changchun, 130021, People's Republic of China.
    Introduction: We aimed to carry out a retrospective study from a single institution to determine whether radioactive iodine (RAI) ablation decreases the risk of recurrence of papillary thyroid microcarcinoma (PTMC) patients that presented with lateral lymph node metastasis (LLNM).

    Methods: We retrospectively analyzed a total of 6361 consecutive PTMC patients who initially underwent surgery for the treatment of thyroid carcinoma at the First Hospital of Jilin University, between January 2005 and February 2015. Altogether, 137 patients with PTMC with LLNM have been enrolled in our study. Read More

    MiR-195 Inhibits Tumor Growth and Metastasis in Papillary Thyroid Carcinoma Cell Lines by Targeting CCND1 and FGF2.
    Int J Endocrinol 2017 27;2017:6180425. Epub 2017 Jun 27.
    Department of Endocrinology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
    Background: MicroRNA (miRNA) dysregulation was commonly seen in papillary thyroid carcinoma (PTC), and miR-195 was verified to be downregulated in PTC by the large data set analysis from The Cancer Genome Atlas (TCGA). Our study aimed to explore the biological functions and the underlying molecular mechanisms of miR-195 in PTC.

    Methods: The relative expression of miR-195 and its target genes were assessed by quantitative RT-PCR assay in 38 pairs of PTC and the adjacent thyroid tissues. Read More

    Molecular alterations of coexisting thyroid papillary carcinoma and anaplastic carcinoma: identification of TERT mutation as an independent risk factor for transformation.
    Mod Pathol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.
    Thyroid papillary carcinoma is the most common endocrine neoplasm and generally carries a favorable prognosis. However, a small subset of papillary carcinomas transforms into anaplastic carcinoma, an undifferentiated cancer with a dismal prognosis. Recent studies using next-generation sequencing revealed the genomic landscape of papillary carcinoma and anaplastic carcinoma. Read More

    Immune Escape Mechanism is Impaired in the Microenvironment of Thyroid Lymph Node Metastasis.
    Endocr Pathol 2017 Jul 20. Epub 2017 Jul 20.
    Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo Street, Campinas, SP, Brazil.
    We previously identified the infiltration of CD8+ lymphocytes and COX2 expression as an independent factor of risk for recurrence in papillary thyroid carcinoma (PTC) patients. However, the presence of lymph node (LN) metastasis at diagnosis lost its significance in a multivariate model analysis. These results encouraged us to compare the immune cells arrangement in the microenvironment of the LN metastasis and the primary tumor. Read More

    HER-2÷neu expression in different histological subtypes of papillary thyroid carcinoma.
    Rom J Morphol Embryol 2017 ;58(2):439-444
    Department of Morphofunctional Sciences - Histology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;
    The identification and validation of new, complementary prognostic factors represents a challenging issue in thyroid pathology, opening the perspective of papillary thyroid carcinoma (PTC) stratification based on differences of aggressiveness at molecular level. Our study aims to analyze the HER-2÷neu expression in different subtypes of PTC and its relationship with the classical clinicopathological factors. We investigated 120 cases of sporadic PTC. Read More

    Transoral robotic thyroidectomy: lessons learned from an initial consecutive series of 24 patients.
    Surg Endosc 2017 Jul 19. Epub 2017 Jul 19.
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
    Background: Transoral thyroid surgery is an ideal method for minimally invasive thyroidectomy, as there is less flap dissection during the procedure and no postoperative scars. Nonetheless, technical obstacles have precluded the wide dissemination of this procedure. We present the surgical procedures and outcomes of transoral robotic thyroidectomy (TORT). Read More

    High Expression of Angiopoietin-1 is Associated with Lymph Node Metastasis and Invasiveness of Papillary Thyroid Carcinoma.
    World J Surg 2017 Jul 17. Epub 2017 Jul 17.
    Department of Otolaryngology-Head and Neck Surgery, Research Institute for Medical Sciences, Chungnam National University School of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon, 301-721, Republic of Korea.
    Background: We investigated the expression of angiopoietins in patients with papillary thyroid carcinoma (PTC) and the role of angiopoietins as biomarkers predicting the aggressiveness of PTC.

    Methods: Expression of angiopoietins was evaluated by immunohistochemistry of tumor specimens from patients with PTC. We demonstrated potential correlations between expression of angiopoietins and clinicopathologic features. Read More

    Immunohistochemical expression of ER-α and PR in papillary thyroid carcinoma.
    Ecancermedicalscience 2017 13;11:748. Epub 2017 Jun 13.
    Department of Oncology, Faculty of Medicine, Menoufia University, Gamal Abd-Elnaser street, Shebein Elkom 32511, Egypt.
    Papillary thyroid carcinoma (PTC) is the most common thyroid cancer with multiple risk factors including exposure to ionising radiation. Oestrogens contribute to papillary carcinoma development by promoting cell proliferation and invasion of mutated epithelial follicular cells. The present study aimed to assess ER-α and PR expression in PTC and to correlate their expression with the clinicopathological parameters in this cancer. Read More

    The role of adjuvant external beam radiation therapy for papillary thyroid carcinoma invading the trachea.
    Radiat Oncol J 2017 Jun 30;35(2):112-120. Epub 2017 Jun 30.
    Department of Radiation Oncology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.
    Purpose: To evaluate the effect of adjuvant external beam radiation therapy (EBRT) on local failure-free survival rate (LFFS) for papillary thyroid cancer (PTC) invading the trachea.

    Materials And Methods: Fifty-six patients with locally advanced PTC invading the trachea were treated with surgical resection. After surgery, 21 patients received adjuvant EBRT and radioactive iodine therapy (EBRT group) and 35 patients were treated with radioactive iodine therapy (control group). Read More

    The epigenetic landscape of differentiated thyroid cancer.
    Mol Cell Endocrinol 2017 Jul 12. Epub 2017 Jul 12.
    Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
    Differentiated thyroid carcinoma of follicular cell-derivation is the most common endocrine neoplasm with a rapidly increasing incidence. The majority represent papillary carcinomas; more rarely, they are follicular carcinomas. The vast majority have indolent behavior, however a significant proportion progress to develop lymph node metastases and a smaller proportion disseminate systemically. Read More

    Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures.
    Endocr Pathol 2017 Jul 14. Epub 2017 Jul 14.
    Department of Pathology, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA.
    Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Read More

    Surgery for Cardiac Papillary Fibroelastoma: A 12-Year Single Institution Experience.
    Med Sci Monit Basic Res 2017 Jul 14;23:258-263. Epub 2017 Jul 14.
    Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg, Germany.
    BACKGROUND We reviewed our clinical experience with cardiac papillary fibroelastoma from 2005 to 2017. The objective of this study was to investigate the clinical and operative data, as well as the early survival rate and immediate postoperative complications. MATERIAL AND METHODS We performed a retrospective analysis of 11 patients (eight males and three females) who underwent resection of cardiac papillary fibroelastoma in our institution. Read More

    Brugada syndrome in a patient with amyotrophic lateral sclerosis: a case report.
    J Med Case Rep 2017 Jul 14;11(1):192. Epub 2017 Jul 14.
    Department of Neurology, University of Missouri Healthcare, 5 Hospital Drive, CE 540, Columbia, MO, 65201, USA.
    Background: Amyotrophic lateral sclerosis is a fatal neuromuscular disorder characterized by progressive death of the upper and lower motor neurons in the central nervous system. Patients with this disease die mostly as a result of respiratory failure; however, owing to prolonged survival through assisted ventilation, cardiovascular causes are increasingly responsible for mortality. We report what is to the best of our knowledge the first case of type 2 Brugada syndrome causing ventricular tachyarrhythmia and cardiac arrest in a patient with upper limb onset amyotrophic lateral sclerosis. Read More

    LONG TERM OUTCOMES AND PROGNOSTIC FACTORS IN PATIENTS WITH DIFFERENTIATED THYROID CANCER AND DISTANT METASTASES.
    Endocr Pract 2017 Jul 13. Epub 2017 Jul 13.
    Endocrine Institute, Assaf Harofeh Medical Center, Zerifin.
    Objective: Distant metastatic spread is the most frequent cause of thyroid cancer-related death. The objective of this study was to evaluate overall and disease-related survival of patients with differentiated thyroid cancer (DTC) and distant metastases (DM) attending a single medical center and to investigate variables predictive of better long-term outcomes.

    Methods: The Rabin Medical Center Thyroid Cancer Registry was searched for patients with DM from DTC. Read More

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