202,542 results match your criteria Thyroid Nodule Imaging


Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

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December 2018

Early experience of transoral thyroidectomy: Comparison of robotic and endoscopic procedures.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.

Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More

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December 2018
2 Reads

Unexpected discrepancies in hospital administrative databases can impact the accuracy of monitoring thyroid surgery outcomes in France.

PLoS One 2018 6;13(12):e0208416. Epub 2018 Dec 6.

Department of General and Endocrine Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.

Objective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.

Background: Administrative data are increasingly used to track surgical outcomes.

Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included. Read More

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December 2018
1 Read

Gender Alters the MHC Class I HLA-A Association with Polyglandular Autoimmunity.

J Clin Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

Molecular Thyroid Research Laboratory, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.

Context: The Major Histocompatibility Complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA).

Objective: To evaluate the impact of gender on human leukocyte antigen (HLA) association with PGA for the first time.

Design: Cross-sectional immunogenetic study. Read More

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December 2018
1 Read

Trends in the incidence and mortality of cancer in Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

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December 2018

Apocrine papillary lesion: comparison of pathological findings from 22 years previously and the present.

Breast Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. Read More

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December 2018

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.

Endocrine 2018 Dec 5. Epub 2018 Dec 5.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background: Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B vs. Read More

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December 2018
2 Reads

Oxygen reserve index (ORi™) contributes to prediction of hypoxemia and patient safety during tracheal stent insertion using rigid bronchoscopy: a case report.

J Clin Monit Comput 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi-Ken, 329-0498, Japan.

The oxygen reserve index (ORi™) is a new noninvasive and continuous variable, which represents a moderate hyperoxygenation status, with a unitless scale between 0.00 and 1.00. Read More

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December 2018

The Association of Various Metabolic Parameters with Multiple Skin Tags.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):40-43. Epub 2018 Oct 1.

Drs. Platsidaki, Vasalou, Gerodimou, Markantoni, Kouris, Gregoriou, Rigopoulos, and Kontochristopoulos are with the Department of Dermatology and Venereology at Andreas Sygros Skin Hospital in Athens, Greece.

Skin tags (STs) are benign skin lesions. Their definite etiology remains unknown. We aim to examine the association of obesity, diabetes mellitus, hyperlipidemia, thyroid abnormalities, acanthosis nigricans, and multiple STs in a Greek primary population. Read More

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October 2018
2 Reads

TFF3 Contributes to Epithelial-Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma Cells via the MAPK/ERK Signaling Pathway.

J Cancer 2018 31;9(23):4430-4439. Epub 2018 Oct 31.

Department of Histology and Embryology, Hebei North University, Zhangjiakou, 075000, China.

Trefoil factor 3 (TFF3) was found to be overexpressed in many types of tumours. Evidence has shown that TFF3 plays an important role in tumour proliferation, migration and invasion metastasis. However, the impact of TFF3 on patients' clinicopathological characteristics and underlying mechanisms remain unknown in papillary thyroid carcinoma (PTC). Read More

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October 2018

Prognostic Impact of TTF-1 Expression in Non-Squamous Non-Small-Cell Lung Cancer: A Meta-Analysis.

J Cancer 2018 20;9(22):4279-4286. Epub 2018 Oct 20.

Division of Hemato-Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea.

Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to gain a better insight into the prognostic role of TTF-1 in patients only with non-squamous (non-SQ) NSCLC. Read More

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October 2018

Thyroid malignancy among patients with thyroid nodules in the United Arab Emirates: a five-year retrospective tertiary Centre analysis.

Thyroid Res 2018 30;11:17. Epub 2018 Nov 30.

6Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.

Objectives: Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring malignancy. Read More

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November 2018

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

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November 2018

Clinical efficacy of transcutaneous triamcinolone acetonide injection for upper eyelid retraction and swelling in patients with thyroid eye disease.

Int Med Case Rep J 2018 9;11:325-331. Epub 2018 Nov 9.

Olympia Eye Hospital, Tokyo, Japan,

Aim: To evaluate the efficacy of transcutaneous triamcinolone acetonide (TA) injection for the treatment of upper eyelid retraction and swelling in thyroid eye disease (TED) patients.

Patients And Methods: This is a case series. Three euthyroid TED patients with features of both upper eyelid retraction and swelling were recruited. Read More

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November 2018

Clinicopathological and prognostic significance of circulating tumor cells in patients with esophageal cancer: a meta-analysis.

Onco Targets Ther 2018 12;11:8053-8061. Epub 2018 Nov 12.

Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China,

Background: The aim of this meta-analysis was to assess the clinicopathological and prognostic significance of circulating tumor cells (CTCs) in patients with esophageal cancer (EC).

Methods: We searched PubMed, EMBASE, Science Citation Index Expanded, Cochrane library (from inception to July 2018) with the keywords "esophageal cancer", "circulating tumor cells", "prognosis", and "peripheral blood". HR, risk ratio (RR), OR, and their 95% CIs were set as effect measures. Read More

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November 2018
1 Read

Peritumoral implantation of hydrogel-containing nanoparticles and losartan for enhanced nanoparticle penetration and antitumor effect.

Int J Nanomedicine 2018 13;13:7409-7426. Epub 2018 Nov 13.

Department of Thyroid and Breast Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China,

Background And Purpose: Nanoparticle-loaded hydrogels - localized drug delivery devices containing a combination of therapeutic nanoparticles and implantable hydrogel - have been recipients of increased focus and interest for cancer treatment. However, it is difficult for the released nanoparticles to penetrate deeply into tumors because of the dense collagen network in the tumor extracellular matrix, which greatly limits their antitumor effect. We hypothesized that the implantation of a hydrogel loaded with both nanoparticles and losartan (Los) might enhance penetration because Los has been proven to effectively reduce collagen levels in various tumors. Read More

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November 2018

LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.

Cell Death Dis 2018 Dec 5;9(12):1167. Epub 2018 Dec 5.

Department of Radiation Oncology, Zhejiang Provincial People' s Hospital, People' s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, P.R. China.

Abstact: Conventional therapies and novel molecular targeted therapies against breast cancer have gained great advances over the past two decades. However, poor prognosis and low survival rate are far from expectation for improvement, particularly in patients with triple negative breast cancer (TNBC). Here, we found that lncRNA DANCR was significantly overregulated in TNBC tissues and cell lines compared with normal breast tissues or other type of breast cancer. Read More

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December 2018

Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination in Fukushima Prefecture.

Sci Rep 2018 Dec 5;8(1):17661. Epub 2018 Dec 5.

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima-city, Fukushima, 960-1295, Japan.

Following the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on 11 March 2011, there have been concerns regarding the health impacts of the ensuing radioactive environmental contamination, which was spatially heterogeneous. This study aimed to assess the geographical variability of thyroid cancer prevalence among children and adolescents in Fukushima Prefecture. We computed the sex- and age-standardised prevalence ratio using 115 diagnosed or suspected thyroid cancer cases among approximately 300,000 examinees at the first-round ultrasound examination during 2011-2015 from 59 municipalities in the prefecture, under the Fukushima Health Management Survey. Read More

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December 2018

Intraoperative rapid aspiration cytological method for parathyroid glands identification and protection.

Endocr J 2018 Dec 5. Epub 2018 Dec 5.

Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.

To explore new methods for intraoperative identification of parathyroid glands, 86 thyroid cancer patients, admitted to Xijing hospital from July 2017 to July 2018, were included. During lymph node dissection, parathyroid glands were firstly judged by clinician eyeballing, based on his clinical experience. Then, cytological detection was used for rapid identification via Diff-quik staining. Read More

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December 2018

T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Background: T cell dysfunction occurs in many diseases, especially in chronic virus infection and cancers. However, up to now, little is known on the distinctions in T cell exhaustion between cancer and chronic virus infection. The objective of this study is to explore the transcriptional similarities and differences in exhausted CD8 +T cell between chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Read More

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December 2018

High-accuracy Detection of Preoperative Thyroid Nodules Using Combination of BRAF Mutation and TMPRSS4 mRNA Level.

Arch Med Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address:

Background: Papillary thyroid cancer (PTC) is the most common epithelial thyroid tumor, accounting for more than 80% of all thyroid cancers. Though the fine needle aspiration biopsy (FNAB) represents as the golden standard for the diagnostics of thyroid nodules, there is a ∼25% risk of indeterminate cytological features. TMPRSS4 is a newly found transmembrane serine protease which was overexpressed in papillary thyroid cancer (PTC). Read More

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December 2018

Carence en iode pendant la grossesse.

Rev Prat 2016 Nov;67(9):998-1000

Service de gynécologieobstétrique, hôpital Beaujon, AP-HP, Clichy, France.

Iodine deficiency during pregnancy. Iodine is a necessary element to thyroid hormones synthesis, and is essential in neurological development. Iodine needs increases during pregnancy. Read More

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November 2016

Monosodium Glutamate in the Diet Does Not Raise Brain Glutamate Concentrations or Disrupt Brain Functions.

Authors:
John D Fernstrom

Ann Nutr Metab 2018 3;73 Suppl 5:43-52. Epub 2018 Dec 3.

The non-essential amino acid glutamate participates in numerous metabolic pathways in the body. It also performs important physiologic functions, which include a sensory role as one of the basic tastes (as monosodium glutamate [MSG]), and a role in neuronal function as the dominant excitatory neurotransmitter in the central nervous system. Its pleasant taste (as MSG) has led to its inclusion as a flavoring agent in foods for centuries. Read More

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December 2018

Thyrotropin receptor antibody: A novel risk indicator for pregnancy loss.

Clin Biochem 2018 Nov 30. Epub 2018 Nov 30.

Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address:

Background: Thyroid autoantibody has been associated with adverse pregnancy outcomes. However, thyroid-receptor antibody (TRAb) has not been considered as a potential risk assessment indicator for adverse pregnancy outcomes. Therefore, we assessed the role of TRAb in evaluation of the risk of adverse pregnancy outcomes. Read More

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November 2018

Thyroid state affects HO removal by rat heart mitochondria.

Arch Biochem Biophys 2018 Nov 30. Epub 2018 Nov 30.

Dipartimento di Biologia, Università di Napoli Federico II, I-80126, Napoli, Italy.

We investigated the effects of thyroid state on the mechanisms underlying rat heart mitochondrial capacity to remove HO produced by an exogenous source. The removal rates were higher in the presence of respiratory substrates independently from thyroid state and were higher in hyperthyroid than in hypothyroid preparations. The thyroid state linked changes in HO removal rates mirrored those in HO release rates showing that endogenous and exogenous HO do not compete for the removing system. Read More

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November 2018

Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

O Dekkers, Internal Medicine, Leids Universitair Medisch Centrum, Leiden, Netherlands.

Introduction: The association between type 1 diabetes (T1D) and other auto-immune diseases is well-known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking.

Methods: We searched Pubmed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo, and adrenal gland insufficiency. Read More

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December 2018
2 Reads

Organ doses evaluation for chest computed tomography procedures with TL dosimeters: Comparison with Monte Carlo simulations.

J Appl Clin Med Phys 2018 Dec 3. Epub 2018 Dec 3.

Group of Radiation Dosimetry and Medical Physics, Institute of Physics, University of São Paulo (IFUSP), São Paulo, SP, Brazil.

Purpose: To evaluate organ doses in routine and low-dose chest computed tomography (CT) protocols using an experimental methodology. To compare experimental results with results obtained by the National Cancer Institute dosimetry system for CT (NCICT) organ dose calculator. To address the differences on organ dose measurements using tube current modulation (TCM) and fixed tube current protocols. Read More

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December 2018

Comparative analysis of radiation dose and image quality between organ dose modulation and 3D smart mA modulation during head-neck CT angiography.

J Xray Sci Technol 2018 Nov 29. Epub 2018 Nov 29.

Medical school, Hebei University, China.

Objective: To assess the difference in absorbed organ dose and image quality for head-neck CT angiography using organ dose modulation compared with 3D smart mA modulation in different body mass indices (BMIs) using an adaptive statistical iterative reconstruction (ASiR-V) algorithm.

Methods: Three hundred patients underwent head-neck CTA were equally divided into three groups: A (18.5 kg/m2≦BMI <  24. Read More

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November 2018
1 Read

Evaluation of Reconstruction Parameters for Two-Dimensional Comb-push Ultrasound Shear Wave Elastography.

IEEE Trans Ultrason Ferroelectr Freq Control 2018 Nov 30. Epub 2018 Nov 30.

Shear wave elastography (SWE) is a noninvasive ultrasound imaging modality used in the assessment of the mechanical properties of tissues such as the liver, kidney, skeletal muscle, thyroid and the breast. Among the methods used to perform SWE is the comb-push ultrasound shear elastography (CUSE) method. This method uses multiple focused ultrasound beams to generate push beams with acoustic radiation force. Read More

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November 2018

Total circulating cell-free miRNA in plasma as a predictive biomarker of the thyroid diseases.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Vocational Health College, Canakkale Onsekiz Mart University, Canakkale, Turkey.

Background: Thyroid cancer is a common endocrine cancer. Great progress has been made in resolving its molecular mechanisms in recent years. The molecular changes observed in thyroid cancer can be used as biomarkers for diagnostic, prognostic and therapeutic purposes. Read More

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December 2018
1 Read

Myo-inositol in autoimmune thyroiditis, and hypothyroidism.

Rev Endocr Metab Disord 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Via Savi, 10, I-56126, Pisa, Italy.

Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns is involved in the intracellular thyroid-stimulating hormone (TSH) signaling, via Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) (PIP-3). Read More

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December 2018

Surgical management of intrathoracic goitres.

Eur Arch Otorhinolaryngol 2018 Nov 30. Epub 2018 Nov 30.

Otorhinolaryngology Head and Neck Surgery, University of Udine School of Medicine, Udine, Italy.

Background: Intrathoracic goitres (ITG) often present with compressive symptoms and require specialised care by experienced surgical teams. Most ITG can be accessed by a transcervical approach (TCA) and only between 1 and 15% will require an extracervical approach (ECA). Many controversies exist regarding the clinical presentation, evaluation, selection of cases for ECA, surgical technique and outcomes. Read More

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November 2018
1 Read

Preliminary study on application of augmented reality visualization in robotic thyroid surgery.

Ann Surg Treat Res 2018 Dec 26;95(6):297-302. Epub 2018 Nov 26.

Department of Biomedical Engineering, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Increased robotic surgery is attended by increased reports of complications, largely due to limited operative view and lack of tactile sense. These kinds of obstacles, which seldom occur in open surgery, are challenging for beginner surgeons. To enhance robotic surgery safety, we created an augmented reality (AR) model of the organs around the thyroid glands, and tested the AR model applicability in robotic thyroidectomy. Read More

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December 2018
1 Read

Current controversies and future directions in the diagnosis and management of differentiated thyroid cancers.

Gland Surg 2018 Oct;7(5):473-486

Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

Despite the development of novel diagnostic, surgical, and chemotherapeutic approaches to differentiated thyroid cancers (DTCs), the diagnosis and management of these tumors remains controversial. The most recent American Thyroid Association (ATA) guidelines, released in 2015, reflect a recent shift towards less aggressive management for patients with DTCs. However, many clinicians have expressed concern that more conservative management will put patients at risk for disease recurrence and metastasis. Read More

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October 2018

Gasless, transaxillary robotic neck dissection: the technique and evidence.

Gland Surg 2018 Oct;7(5):466-472

Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea.

Robotic neck dissection (ND) for the thyroid cancer with lateral neck metastasis case is one of the emerging surgical techniques, and has been highlighted as minimally invasive surgical technique recently. Gasless, transaxillary robotic approach enabled the surgeon to do meticulous and precise dissection in the complex procedure, such as ND, eventually showed favorable surgical safety and outcomes, as well as superior functional and cosmetic benefits. In this article, the author would like to introduce the detailed techniques and secure evidences for the gasless, transaxillary robotic ND. Read More

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October 2018
3 Reads

Impact of completion thyroidectomy timing on post-operative complications: a systematic review and meta-analysis.

Gland Surg 2018 Oct;7(5):458-465

Department of Surgery, King Khalid University Hospital, Riyadh, Saudi Arabia.

Background: Despite a number of studies, the optimal timing of completion thyroidectomy is still controversial. This systematic review and meta-analysis aims to compare the outcomes of early versus delayed completion thyroidectomy regarding post-operative complications.

Methods: We performed a systematic review in electronic databases including: bumped, Scopus, Medline and Google Scholar to identify relevant studies. Read More

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October 2018

Validation of ultrasound as a diagnostic tool to assess vocal cord motion in an animal feasibility study.

Gland Surg 2018 Oct;7(5):433-439

Department of Otolaryngology, Head and Neck Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: Post-thyroidectomy dysphonia can result from recurrent laryngeal nerve (RLN) injury. Confirmation of postoperative recurrent nerve function has prompted many surgeons to advocate laryngoscopic examination. Indirect and flexible laryngoscopy permit visualization of vocal cord motion, but not all thyroid surgeons are skilled in these techniques. Read More

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October 2018
1 Read

Comment on "Refining Dynamic Risk Stratification and Prognostic Groups for Differentiated Thyroid Cancer With TERT Promoter Mutations".

Authors:
Ashok R Shaha

Gland Surg 2018 Oct;7(5):426-427

Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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October 2018
1 Read

Comment on "The Diagnosis and Management of Thyroid Nodules: A Review".

Authors:
Ashok R Shaha

Gland Surg 2018 Oct;7(5):424-425

Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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October 2018
2 Reads

A case report of traditional Korean medicine treatments on uterine myoma with thyroid cancer.

Integr Med Res 2018 Dec 25;7(4):303-306. Epub 2018 Oct 25.

Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-jeon University, Daejeon, Republic of Korea.

Uterine myoma is a common benign tumor. When the symptoms are not severe, patients are often suggested to wait for menopause without treatment. If the size becomes too large or the symptoms get worse, the patient will receive surgery or hormone therapy. Read More

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December 2018

Efficacy of radioactive iodine treatment of graves' hyperthyroidism using a single calculated I dose.

Clin Diabetes Endocrinol 2018 28;4:20. Epub 2018 Nov 28.

1Nuclear Medicine/Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5028 USA.

Objective: To evaluate the success rate of therapeutic administration of a single calculated I activity for eliminating hyperthyroidism due to Graves' disease.

Methods And Materials: Patients with Graves' hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and clinical examination and received a calculated I activity of 0.2 mCi per estimated gram of thyroid tissue, adjusted for the 24-h RAIU. Read More

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November 2018

Evaluation of the physical and biological dosimetry methods in iodine-131-treated patients.

World J Nucl Med 2018 Oct-Dec;17(4):253-260

Department of Nuclear Medicine, Kayseri Training and Research Hospital, 38010 Kayseri, Turkey.

The aim of the study was to compare physical and biological dosimetry methods in iodine-131 (I-131)-receiving patients. The present study comprised of 47 patients (mean age: 47.9 ± 15. Read More

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December 2018

A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review.

Clin Med Insights Oncol 2018 26;12:1179554918813535. Epub 2018 Nov 26.

Department of Pathology, Wanbei Coal-Electricity Group General Hospital, Suzhou, China.

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Read More

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November 2018

Transverse cervical vascular pedicle: It's extended use as 'second-line' recipient vessels in thoracic and upper arm reconstructions in addition to head-and-neck reconstructions.

Indian J Plast Surg 2018 May-Aug;51(2):182-189

Department of Plastic and Reconstructive Surgery, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.

Background: Selection of recipient vessels is one of the key factors for a successful microvascular reconstruction. Non-availability of primary recipient vessels in the vicinity necessitates surgeon to approach a remote second-line vascular access. Transverse cervical vessels (TCV) have been described as second-line vascular access for head-and-neck reconstructions. Read More

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December 2018

Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease.

Anticancer Res 2018 Dec;38(12):6847-6853

Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland.

Background/aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid.

Patients And Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients.

Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Read More

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December 2018

Effect of Heparin-Protamine Treatment on Thyroid Cancer Cell Lines.

Anticancer Res 2018 Dec;38(12):6759-6762

Division of Molecular Cell Biology, Core Research Facilities of Basic Science, The Jikei University School of Medicine, Tokyo, Japan.

Background: Anticoagulation therapy is often used to prevent stroke in patients with thyroid cancer. However, the effects of heparin and protamine on thyroid cancer are unknown; therefore, we examined the response of thyroid cancer cell lines to heparin and protamine.

Materials And Methods: Cytotoxic assay for heparin-protamine treatment was examined on SW1736, 8505c and 8305c cell lines. Read More

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December 2018
2 Reads

Effect of Combined Epigenetic Treatments and Ectopic NIS Expression on Undifferentiated Thyroid Cancer Cells.

Anticancer Res 2018 Dec;38(12):6653-6662

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Poorly differentiated (PDTC) and anaplastic thyroid (ATC) cancer cells are characterized by the acquisition of epigenetic abnormalities, leading to the silencing of both the sodium iodide co-transporter and the Coxsackie adenovirus receptor. As aberrant histone acetylation and DNA methylation represent epigenetic mechanisms involved in neoplastic transformation, our study investigated the anticancer properties of epigenetic modifiers in thyroid carcinoma.

Materials And Methods: The cytotoxicity and gene expression modulation of histone deacetylase and DNA methyltransferase inhibitors were evaluated in both PDTC and ATC. Read More

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December 2018
1 Read

Long-term effects of radioiodine treatment on salivary gland function in adult survivors of pediatric differentiated thyroid carcinoma.

J Nucl Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Netherlands.

Pediatric differentiated thyroid cancer (DTC) is a rare disease. Initial treatment of DTC consists of a (near) total thyroidectomy and radioactive iodine (I) therapy. Previous studies in adults showed that I treatment may result in a reduced salivary gland function. Read More

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November 2018

PTEN Hamartoma Tumor Syndrome and Immune Dysregulation.

Transl Oncol 2018 Nov 29;12(2):361-367. Epub 2018 Nov 29.

Department of Human Genetics, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands; Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525, GA, Nijmegen, The Netherlands. Electronic address:

Carriers of a pathogenic germline mutations in the PTEN gene, a well-known tumor suppressor gene, are at increased risk of multiple benign and malignant tumors, e.g. breast, thyroid, endometrial and colon cancer. Read More

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November 2018
1 Read

MicroRNA-146b-5p as an oncomiR promotes papillary thyroid carcinoma development by targeting CCDC6.

Cancer Lett 2018 Nov 29. Epub 2018 Nov 29.

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Faculty of Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:

The microRNA-146-5p (miR-146b-5p) is known to be involved in the development of papillary thyroid cancer (PTC); however, the underlying mechanism is unclear. Here we have investigated the biological functions and underlying molecular mechanisms of miR-146b-5p in PTC. The expression of miR-146-5p was assessed in 92 pairs of PTC and adjacent normal tissues and showed correlation with the clinicopathological status such as the tumour size. Read More

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November 2018