4,006 results match your criteria Thyroid Nodule Imaging


[Anhydrous Ethanol Improves Efficiency of Radiofrequency Ablation for the Treatment of Benign Thyroid Nodules:A Prospective Randomized Controlled Trial].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):331-337

Department of Ultrasound,Chinese PLA General Hospital,Beijing 100853,China.

To investigate the value of injecting a small amount of absolute ethanol into the benign solid nodules of the thyroid before radiofrequency ablation(RFA)to improve the efficiency of radiofrequency ablation. A total of 98 eligible patients(98 nodules)with pathologically confirmed benign solid nodules who were treated in our center from December 2016 to February 2018 were included and randomized into ethanol ablation(EA)combined with radiofrequency ablation(RFA)group(EA+RFA group)and RFA group,with 49 patients in each group.Routine ultrasound,contrast-enhanced ultrasound(CEUS),and thyroid function test were performed before treatment and 1,3,6,and 12 months after treatment. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11512DOI Listing

Nodule Localization in Thyroid Ultrasound Images with a Joint-Training Convolutional Neural Network.

J Digit Imaging 2020 Jun 30. Epub 2020 Jun 30.

Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, China.

The accurate localization of nodules in ultrasound images can convey crucial information to support a reliable diagnosis. However, this is usually challenging due to low contrast and image artifacts, especially in thyroid ultrasound images where nodules are relatively small in most cases. To address these problems, in this paper, we propose a joint-training convolutional neural network (CNN) for thyroid nodule localization in ultrasound images. Read More

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http://dx.doi.org/10.1007/s10278-020-00366-6DOI Listing

Incidental detection of unexpected neck lymphatic III level node metastasis from occult papillary thyroid carcinoma during cervical disc surgery: first literature report.

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Pathology Department, District Hospital, Arkonska 4, 71-455 Szczecin, Poland.

Background: The regional lymph node metastases of papillary thyroid carcinoma are very common. Subclinical neck lymphatic malignancy of the undiagnosed papillary carcinoma can be found by chance at autopsy or intravitally, especially during neck imaging scrutiny for other reasons. And cervical lymph node metastasis as the initial manifestation of occult papillary thyroid carcinoma is very rare phenomenon. Read More

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http://dx.doi.org/10.5603/EP.a2020.0031DOI Listing

The Diagnostic Role of Computed Tomography for ACR TI-RADS 4-5 Thyroid Nodules With Coarse Calcifications.

Front Oncol 2020 5;10:911. Epub 2020 Jun 5.

Department of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Coarse calcifications are prone to cause echo attenuation during ultrasonography (US) and hence affect the classification of benign and malignant nodules. This study aimed to investigate the diagnostic role of computed tomography (CT) for differentiating the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) 4-5 nodules with coarse calcifications. CT data of 216 ACR TI-RADS 4-5 nodules with coarse calcifications confirmed by surgery and pathology in 207 patients were analyzed retrospectively. Read More

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http://dx.doi.org/10.3389/fonc.2020.00911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289989PMC

Comparison of Ultrasonography Features and K-TIRADS for Isthmic and Lobar Papillary Thyroid Carcinomas: A Single-Center Study.

Front Endocrinol (Lausanne) 2020 4;11:328. Epub 2020 Jun 4.

Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, South Korea.

This study aimed to compare ultrasonography (US) features and the Korean-Thyroid Imaging Reporting and Data System (K-TIRADS) categories for diagnosing isthmic and lobar papillary thyroid carcinomas (PTC). From January 2009 to December 2012, 163 patients who underwent thyroid surgery and were confirmed with a post-operative histopathological diagnosis of isthmic PTC were retrospectively included. Fifty-nine patients were excluded because their tumor size was <0. Read More

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http://dx.doi.org/10.3389/fendo.2020.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287017PMC

Use of strain ultrasound elastography versus fine-needle aspiration cytology for the differential diagnosis of thyroid nodules: a retrospective analysis.

Clinics (Sao Paulo) 2020 22;75:e1594. Epub 2020 Jun 22.

Department of Doppler Ultrasonil, Xingtai People's Hospital, Xingtai, Hebei, China, 054001.

Objective: Fine-needle aspiration cytology is the risk stratification tool for thyroid nodules, and ultrasound elastography is not routinely used for the differential diagnosis of thyroid cancer. The current study aimed to compare the diagnostic parameters of ultrasound elastography and fine-needle aspiration cytology, using surgical pathology as the reference standard.

Methods: In total, 205 patients with abnormal thyroid function test results underwent ultrasound-guided fine-needle aspiration cytology on the basis of the American College of Radiology Thyroid Imaging-Reporting and Data System classification and strain ultrasound elastography according to the ASTERIA criteria. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297517PMC

Clinicopathologic factors and preoperative ultrasonographic characteristics for predicting central lymph node metastasis in papillary thyroid microcarcinoma: a single center retrospective study.

Braz J Otorhinolaryngol 2020 Jun 4. Epub 2020 Jun 4.

Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Department of Medical Imaging, Liaoning Province, People's Republic of China. Electronic address:

Introduction: The treatment of papillary thyroid microcarcinoma remains controversial. Central lymph node metastasis is common in papillary thyroid microcarcinoma and it is an important consideration in treatment strategy selection.

Objective: The aim of this study was to investigate clinicopathologic risk factors and thyroid nodule sonographic characteristics for central lymph node metastasis in papillary thyroid microcarcinoma. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.004DOI Listing

Treatment of benign thyroid nodules by radiofrequency thermal ablation

Orv Hetil 2020 07;161(27):1131-1136

Általános Orvostudományi Kar, Transzplantációs és Sebészeti Klinika,Semmelweis Egyetem, Budapest, Baross u. 23-25., 1082.

Introduction: Benign thyroid nodules are frequent findings in imaging studies, most of the time not requiring any intervention. Treatment is usually started when nodules increase in size, the patient becomes symptomatic or clinically relevant hyperthyroidism develops. Thermoablation is an effective alternative modality. Read More

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http://dx.doi.org/10.1556/650.2020.31726DOI Listing

Performance of EU-TIRADS in malignancy risk stratification of thyroid nodules. A meta-analysis.

Eur J Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

P Trimboli, Clinic for Nuclear Medicine and Competence Center for Thyroid Diseases, Imaging Institute of Southern Switzerland, Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Objective: Several thyroid imaging reporting and data systems (TIRADS) have been proposed to stratify the malignancy risk of thyroid nodule by ultrasound. The TIRADS by the European Thyroid Association, namely EU-TIRADS, was the last one to be published.

Design: We conducted a meta-analysis to assess the prevalence of malignancy in each EU-TIRADS class and the performance of EU-TIRADS class 5 versus 2, 3 and 4 in detecting malignant lesions. Read More

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http://dx.doi.org/10.1530/EJE-20-0204DOI Listing

Intermixed medullary and papillary thyroid cancer in a patient with renal cell carcinoma.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, Illinois, USA.

Summary: We report a rare case of concurrent medullary thyroid cancer (MTC) and papillary thyroid cancer (PTC) with intermixed disease in several of the lymph node (LN) metastases in a patient who was subsequently diagnosed with clear cell renal cell carcinoma (RCC). A 56 year old female presented with dysphagia and was found to have a left thyroid nodule and left superior cervical LN with suspicious sonographic features. Fine needle aspiration biopsy (FNAB) demonstrated PTC in the left thyroid nodule and MTC in the left cervical LN. Read More

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http://dx.doi.org/10.1530/EDM-20-0025DOI Listing

False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice.

Diagnostics (Basel) 2020 Jun 6;10(6). Epub 2020 Jun 6.

Department of Diagnostic Imaging, University of Pécs Medical School, Ifjúság út 13, 7624 Pécs, Hungary.

This study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards identifying thyroid entities associated with CAD system misdiagnoses. Two-hundred patients referred to thyroid US were prospectively enrolled. An experienced radiologist evaluated the thyroid nodules and saved axial images for further offline blinded analysis using a commercially available CAD system. Read More

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http://dx.doi.org/10.3390/diagnostics10060378DOI Listing

Thyroid Nodule Malignancy Risk Stratification Using a Convolutional Neural Network.

Ultrasound Q 2020 Jun;36(2):164-172

Department of Diagnostic Imaging, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI.

This study evaluates the performance of convolutional neural networks (CNNs) in risk stratifying the malignant potential of thyroid nodules alongside traditional methods such as American College of Radiology Thyroid Imaging Reporting and Data System (ACR TIRADS). The data set consisted of 651 pathology-proven thyroid nodules (500 benign, 151 malignant) from 571 patients collected at a single tertiary academic medical center. Each thyroid nodule consisted of two orthogonal views (sagittal and transverse) for a total of 1,302 grayscale images. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000501DOI Listing

Diagnostic performances of the KWAK-TIRADS classification, elasticity score, and Bethesda System for Reporting Thyroid Cytopathology of TI-RADS category 4 thyroid nodules.

Int J Clin Exp Pathol 2020 1;13(5):1159-1168. Epub 2020 May 1.

Department of Thyroid and Breast Surgery, The Affiliated Hospital of Hangzhou Normal University Hangzhou, China.

Objective: To explore the value of the KWAK Thyroid Imaging Reporting and Data System (KWAK-TIRADS), elasticity score (ES), and Bethesda System for Reporting Thyroid Cytopathology (BSRTC) in the diagnosis of suspicious thyroid nodules.

Materials And Methods: The study included 392 cases of TI-RADS category 4 thyroid nodules that underwent thyroidectomy between January 2017 and October 2019. All patients underwent ultrasonography, ultrasound elastography, and fine-needle aspiration cytology (FNAC) before surgery. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270670PMC

Using the American College of Radiology Thyroid Imaging Reporting and Data System at the Point of Care: Sonographer Performance and Interobserver Variability.

Ultrasound Med Biol 2020 Aug 2;46(8):1928-1933. Epub 2020 Jun 2.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Health System, Baltimore, Maryland, USA.

The purpose of this study was to assess inter-observer variability and performance when sonographers assign features to thyroid nodules on ultrasound using the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS). Fifteen sonographers retrospectively evaluated 100 thyroid nodules and assigned features to each nodule according to ACR TI-RADS lexicon. Ratings were compared with one another and to a gold standard using Fleiss' and Cohen's kappa statistics, respectively. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.04.019DOI Listing

Computer-aided diagnosis system of thyroid nodules ultrasonography: Diagnostic performance difference between computer-aided diagnosis and 111 radiologists.

Medicine (Baltimore) 2020 Jun;99(23):e20634

Ultrasound Medical Center, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

To evaluate the diagnostic efficiency of computer-aided diagnosis (CAD) system and 111 radiologists with different experience in identifying benign and malignant thyroid nodules, and to summarize the ultrasound features that may affect the diagnostic of CAD and radiologists.Fifty thyroid nodules and 111 radiologists were enrolled in this study. All the 50 nodules were diagnosed by the 111 radiologists and the CAD system simultaneously. Read More

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http://dx.doi.org/10.1097/MD.0000000000020634DOI Listing

Ultrasonographic characteristics of medullary thyroid carcinoma according to nodule size: application of the Korean Thyroid Imaging Reporting and Data System and American Thyroid Association guidelines.

Acta Radiol 2020 Jun 3:284185120929699. Epub 2020 Jun 3.

Department of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Few studies have categorized ultrasound (US) findings of various sized medullary thyroid carcinomas (MTCs) according to updated guidelines.

Purpose: To evaluate and compare the differences in US findings of MTC according to nodule size, using the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) and American Thyroid Association (ATA) guidelines.

Material And Methods: The study included 119 patients with 129 MTC nodules, which were surgically confirmed at our institution between March 1999 and September 2017. Read More

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http://dx.doi.org/10.1177/0284185120929699DOI Listing

Contemporary thyroid nodule evaluation and management.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Department of Translational and Precision Medicine, Sapienza University of Rome, Viale del Policlinico, Rome, Italy.

Context: Approximately 60% of adults harbor one or more thyroid nodules. The possibility of cancer is the overriding concern, but only about 5% prove to be malignant. The widespread use of diagnostic imaging and improved access to healthcare favor the discovery of small, subclinical nodules and small papillary cancers. Read More

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http://dx.doi.org/10.1210/clinem/dgaa322DOI Listing
June 2020
6.209 Impact Factor

Thyroid metastasis revealing a lung adenocarcinoma.

Respir Med Case Rep 2020 16;30:101065. Epub 2020 May 16.

Pulmonology Department, Fattouma Bourguiba Hospital, Monastir, Tunisia.

Thyroid metastasis revealing a primary lung cancer is an extremely rare condition. Only few cases have been reported in the literature. A multidisciplinary approach is essential for the diagnosis. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256324PMC

Comparison of 18F-FDG-PET and 18F-FDG-PET/CT for the diagnostic performance in thyroid nodules with indeterminate cytology: A meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20446

Department of Discipline Inspection, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China.

Backgrounds: We performed a meta-analysis to compare F-FDG-PET and F-FDG-PET/CT for the diagnostic performance in thyroid nodules with indeterminate cytology by Bethesda classification.

Methods: PubMed and Embase databases were searched for eligible studies from the earliest available date of indexing through September 2019. Only studies with clearly stated histopathology confirmation were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000020446DOI Listing

Diagnostic accuracy and ability to reduce unnecessary FNAC: A comparison between four Thyroid Imaging Reporting Data System (TI-RADS) versions.

Clin Imaging 2020 Apr 25;65:133-137. Epub 2020 Apr 25.

Radiology Department, Taiping Hospital, Jalan Taming Sari, 34000 Taiping, Perak, Malaysia.

Background: Thyroid Imaging Reporting Data System (TI-RADS) is used to characterize thyroid nodules while reducing unnecessary FNAC. Over the years, several versions of TI-RADS have been developed but there is no consensus on which TI-RADS is the best system. This study aimed to compare the diagnostic accuracy and ability of ACR TI-RADS, EU TI-RADS, K TI-RADS, AI TI-RADS to eliminate unnecessary FNAC. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.04.029DOI Listing

Risk Stratification of Thyroid Nodules with Bethesda III Category: The Experience of a Territorial Healthcare Hospital.

Cureus 2020 May 19;12(5):e8202. Epub 2020 May 19.

Department of Endocrine Surgery, Prince Sultan Military Medical City, Riyadh, SAU.

Background The Bethesda System for Reporting Thyroid Cytolopathology (TBSRTC) is the standardized category-based reporting system for thyroid nodule (TN) aspirations; however, atypia of undetermined significance/follicular lesion of undetermined significance (Bethesda category III, AUS/FLUS) is the most controversial category. The aim of this study was to identify the degree of malignancy risk and the related risk factors in the surgical pathology of the Bethesda Category III thyroid nodules.  Methods A total of 4074 patients (15-90 years, 81. Read More

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http://dx.doi.org/10.7759/cureus.8202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241230PMC

Osteitis Fibrosa Cystica Caused by Hyperparathyroidism Shown on 18F-NaF PET/CT.

Clin Nucl Med 2020 Jul;45(7):577-579

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People's Republic of China.

F-NaF PET/CT in hyperparathyroidism and osteitis fibrosa cystica is rarely reported. We report the case of a 16-year-old boy who underwent NaF PET/CT for the evaluation of bilateral bone destruction, which was incidentally noted on an abdominal x-ray. The PET/CT images identified multiple bony abnormalities in the skull, pelvis, and limbs. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003095DOI Listing

Diagnostic Performance Evaluation of Practice Guidelines, Elastography and Their Combined Results for Thyroid Nodules: A Multicenter Study.

Ultrasound Med Biol 2020 Aug 22;46(8):1916-1927. Epub 2020 May 22.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Ultrasound Research and Education Institute, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, China. Electronic address:

The purpose of this multicenter study was to compare the differential diagnostic value of the 2015 American Thyroid Association (ATA) and 2017 American College of Radiology (ACR) practice guidelines and elastography in thyroid nodules. This study also investigated whether the diagnostic value of practice guidelines can be improved, and the unnecessary biopsy rate decreased in combination with elastography. A total of 498 thyroid nodules were evaluated using the ATA and the ACR guidelines. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.03.031DOI Listing

ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of thyroid nodules and cancer.

Eur J Endocrinol 2020 Jul;183(1):G41-G48

Clinic for Nuclear Medicine and Competence Centre for Thyroid Diseases, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland.

Most patients with thyroid nodules and thyroid cancer (TC) referred for diagnostic work-up and treatment are not considered at higher risk of infection from SARS-CoV-2 compared to the general population. On the other hand, healthcare resources should be spared to the maximum extent possible during a pandemic. Indeed, while thyroid nodules are very common, only a small percentage are cancerous and, in turn, most thyroid cancers are indolent in nature. Read More

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http://dx.doi.org/10.1530/EJE-20-0269DOI Listing

Reproducibility of Ablated Volume Measurement Is Higher with Contrast-Enhanced Ultrasound than with B-Mode Ultrasound after Benign Thyroid Nodule Radiofrequency Ablation-A Preliminary Study.

J Clin Med 2020 May 16;9(5). Epub 2020 May 16.

Division of Interventional Radiology, European Institute of Oncology, IRCCS, 20141 Milan, Italy.

The reproducibility of contrast-enhanced ultrasound (CEUS) and standard B-mode ultrasound in the assessment of radiofrequency-ablated volume of benign thyroid nodules was compared. A preliminary study was conducted on consecutive patients who underwent radiofrequency ablation (RFA) of benign thyroid nodules between 2014 and 2016, with available CEUS and B-mode post-ablation checks. CEUS and B-mode images were retrospectively evaluated by two radiologists to assess inter- and intra-observer agreement in the assessment of ablated volume (Bland-Altman test). Read More

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http://dx.doi.org/10.3390/jcm9051504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291258PMC

Convolutional Neural Network for Breast and Thyroid Nodules Diagnosis in Ultrasound Imaging.

Biomed Res Int 2020 10;2020:1763803. Epub 2020 Jan 10.

Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 63 Duobao Road, Guangzhou, 510000 Guangdong, China.

Objective: The incidence of superficial organ diseases has increased rapidly in recent years. New methods such as computer-aided diagnosis (CAD) are widely used to improve diagnostic efficiency. Convolutional neural networks (CNNs) are one of the most popular methods, and further improvements of CNNs should be considered. Read More

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http://dx.doi.org/10.1155/2020/1763803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199615PMC
January 2020

Multimode ultrasonic technique is recommended for the differential diagnosis of thyroid cancer.

PeerJ 2020 4;8:e9112. Epub 2020 May 4.

Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China.

Background: B-mode ultrasound is one of the most commonly used imaging techniques for evaluating thyroid nodules due to its noninvasive property and excellent performance in terms of discriminating between benign and malignant nodules. However, the accuracy of differential diagnosis strongly depends on the experience of ultrasonographers. In addition to B-mode ultrasound, the elastic mode and contrast-enhanced mode have shown complimentary value in the diagnosis of thyroid nodules. Read More

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http://dx.doi.org/10.7717/peerj.9112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204870PMC

TTF-1 Positive Primary Small Cell Carcinoma of the Breast: A Case Report and Review of the Literature.

Front Endocrinol (Lausanne) 2020 29;11:228. Epub 2020 Apr 29.

Stefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.

Primary small cell carcinoma of the breast (SCCB) is a rare tumor subtype comprising <0.1% of all breast carcinomas. Here we present a case of thyroid transcription factor-1 (TTF-1) positive SCCB that recurred within 3 years of diagnosis in the lung and lymph nodes. Read More

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http://dx.doi.org/10.3389/fendo.2020.00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201766PMC

Clinical and ultrasonographic features of medullary thyroid microcarcinomas compared with papillary thyroid microcarcinomas: a retrospective analysis.

BMC Med Imaging 2020 May 14;20(1):49. Epub 2020 May 14.

Ultrasound Department, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025, China.

Background: To identify the sonographic features that help to differentiate medullary thyroid microcarcinomas (MTMCs) from papillary thyroid microcarcinomas (PTMCs).

Methods: A total of 46 MTMCs in 41 patients and 136 PTMCs in 104 patients that were proven by surgery and pathology were included in the study. Patient age and nodule size were analyzed by independent sample t-tests, and sex, multiplicity and cervical lymph node metastases were analyzed by χ or Fisher's exact tests. Read More

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http://dx.doi.org/10.1186/s12880-020-00444-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227110PMC

Classification of thyroid nodules using ultrasound images.

Bioinformation 2020 29;16(2):145-148. Epub 2020 Feb 29.

Department of Computer Applications, Alagappa University, Karaikudi, Tamilnadu, India.

Medical imaging using image sensors play an essential role in effective diagnosis. Therefore, it is of interest to use medical imaging techniques for the diagnosis of thyroid-linked dysfunction. Ultrasound is the low-cost image processing technique to study internal organs and blood flow in blood vessels. Read More

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http://dx.doi.org/10.6026/97320630016145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196169PMC
February 2020

Partially cystic thyroid cancer on conventional and elastographic ultrasound: a retrospective study and a machine learning-assisted system.

Ann Transl Med 2020 Apr;8(7):495

Department of Ultrasound, West China Hospital of Sichuan University, Chengdu 610041, China.

Background: Thyroid carcinoma constitutes the vast majority of all thyroid cancer, most of which is the solid nodule type. No previous studies have examined combining both conventional and elastic sonography to evaluate the diagnostic performance of partially cystic thyroid cancer (PCTC). This retrospective study was designed to evaluate differentiation of PCTC from benign partially cystic nodules with a machine learning-assisted system based on ultrasound (US) and elastography. Read More

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http://dx.doi.org/10.21037/atm.2020.03.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210215PMC

[Accuracy of two thyroid imaging, reporting and data systems for differential diagnosis of benign and malignant thyroid nodules].

Nan Fang Yi Ke Da Xue Xue Bao 2020 Mar;40(3):400-406

Department of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Objective: To compare the accuracy of two widely used thyroid imaging, reporting and data systems (TI-RADS), namely ACR TI-RADS and Kwak TI-RADS, in the differential diagnosis of benign and malignant thyroid nodules.

Methods: We reviewed the data of 350 thyroid nodules with definite diagnoses by surgical histopathology (=144, 41.14%) or fine needle aspiration (FNA) cytopathology (=206, 58. Read More

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http://dx.doi.org/10.12122/j.issn.1673-4254.2020.03.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167310PMC

Radiation-Associated Thyroid Cancer Surveillance and Management in a Cohort of Late Effects Patients.

World J Surg 2020 May 5. Epub 2020 May 5.

University of Melbourne, Parkville, VIC, Australia.

Background And Aims: Compared to the general population, the incidence of thyroid cancer in childhood and adolescent and young adult malignancy survivors is increased 14.0-18.0 times (CI 11. Read More

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http://dx.doi.org/10.1007/s00268-020-05547-6DOI Listing

Hounsfield Unit Values in ACR TI-RADS 4-5 Thyroid Nodules with Coarse Calcifications: An Important Imaging Feature Helpful for Diagnosis.

Cancer Manag Res 2020 22;12:2711-2717. Epub 2020 Apr 22.

Department of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Purpose: The purpose of this study is to investigate the diagnostic role of Hounsfield unit (HU) values on noncontrast computed tomography (CT) for differentiating benignity from malignancy in the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) 4-5 nodules with coarse calcifications.

Patients And Methods: CT images of 216 ACR TI-RADS 4-5 nodules with coarse calcifications from 207 patients who underwent surgery in our hospital between 2017 and 2019 were retrospectively reviewed. The average HU values (AHUVs) and maximum HU values (MHUVs) of the nodules were measured on noncontrast CT. Read More

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http://dx.doi.org/10.2147/CMAR.S242524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184120PMC

A case of reactive lymphoid hyperplasia of the liver in a patient with autoimmune hepatitis.

Surg Case Rep 2020 May 4;6(1):90. Epub 2020 May 4.

Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Japan.

Background: Reactive lymphoid hyperplasia (RLH) of the liver is a benign disorder. It is usually observed in the skin, orbit, thyroid, lung, breast, or gastrointestinal tract, but rarely in the liver. Since the first report of RLH of the liver in 1981, only 75 cases have been described in the past literature. Read More

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http://dx.doi.org/10.1186/s40792-020-00856-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198675PMC

Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules.

Int J Endocrinol 2020 14;2020:1749351. Epub 2020 Apr 14.

Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.

Background: To explore the correlation between the ultrasound elasticity score (ES) of real-time tissue elastography (RTE) and the malignant risk stratification of the Thyroid Imaging Reporting and Data System (TI-RADS) and to evaluate the added value of RTE to TI-RADS in differentiating malignant nodules from benign ones.

Methods: A total of 1,498 patients (885 women and 613 men; mean age of 43.5 ± 12. Read More

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http://dx.doi.org/10.1155/2020/1749351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178472PMC

The Relationship Between Imaging and Thyroid Cancer Diagnosis and Survival.

Oncologist 2020 Apr 23. Epub 2020 Apr 23.

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.

Background: Controversy exists over whether there has been a true increase in the occurrence of thyroid cancer or overdiagnosis secondary to imaging practices. Because cancer overdiagnosis is associated with detection of indolent disease, overdiagnosis can be associated with perceived improvement in survival.

Materials And Methods: Surveillance, Epidemiology, and End Results-Medicare linked database was used to determine the relationship between type of imaging leading to thyroid cancer diagnosis and survival. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0159DOI Listing

Quantification of Morphological Features in Non-Contrast-Enhanced Ultrasound Microvasculature Imaging.

IEEE Access 2020 21;8:18925-18937. Epub 2020 Jan 21.

Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.

There are significant differences in microvascular morphological features in diseased tissues, such as cancerous lesions, compared to noncancerous tissue. Quantification of microvessel morphological features could play an important role in disease diagnosis and tumor classification. However, analyzing microvessel morphology in ultrasound Doppler is a challenging task due to limitations associated with this technique. Read More

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http://dx.doi.org/10.1109/ACCESS.2020.2968292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179329PMC
January 2020

Diagnosis of Thyroid Nodule with New Ultrasound Imaging Modalities.

VideoEndocrinology 2019 30;7(1). Epub 2020 Mar 30.

University of Connecticut, Farmington, Connecticut.

B-mode ultrasound (US) technology is an integral part of diagnosing and assessing risk stratification of thyroid nodules (TNs). The addition of shear wave elastography and three-dimensional (3D) US imaging may improve risk stratification for thyroid cancer (TC). The patient was evaluated in our clinic with US imaging including B-mode, shear wave elastography, 3D-US, and fine needle aspiration biopsy (FNAB). Read More

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http://dx.doi.org/10.1089/ve.2020.0173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173242PMC

Ultrasound systems for risk stratification of thyroid nodules prompt inappropriate biopsy in autonomously functioning thyroid nodules.

Clin Endocrinol (Oxf) 2020 Jul 5;93(1):67-75. Epub 2020 May 5.

Clinic for Nuclear Medicine and Competence Center for Thyroid Diseases, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Objective: Ultrasound (US) risk stratification systems (RSSs) have been developed to reduce the number of unnecessary fine-needle aspiration (FNA) biopsies in patients with thyroid nodules. Autonomously functioning thyroid nodules (AFTN) account for 5%-10% of palpable lesions and are very rarely malignant. The present study was undertaken to investigate how RSSs classify AFTNs and whether RSSs are able to avoid unnecessary FNA biopsies in such cases. Read More

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http://dx.doi.org/10.1111/cen.14204DOI Listing

Treating thyroid nodules by radiofrequency: is the delivered energy correlated with the volume reduction rate? A pilot study.

Endocrine 2020 Apr 21. Epub 2020 Apr 21.

Endocrinology, Diabetes and Metabolism Department and Center for Thyroid Diseases, A.O. Ordine Mauriziano, Turin, Italy.

Objective: Radiofrequency ablation (RFA) was proven as effective in reducing thyroid nodules' volume. However, whether technical procedure aspects could influence the volume reduction rate (VRR) has not been clarified. This retrospective pilot study aimed to analyze the correlation of RFA power, duration, and energy with VRR. Read More

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http://dx.doi.org/10.1007/s12020-020-02275-8DOI Listing

Application of machine learning to ultrasound images to differentiate follicular neoplasms of the thyroid gland.

Ultrasonography 2020 Jul 29;39(3):257-265. Epub 2020 Feb 29.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study was conducted to evaluate the diagnostic performance of machine learning in differentiating follicular adenoma from carcinoma using preoperative ultrasonography (US).

Methods: In this retrospective study, preoperative US images of 348 nodules from 340 patients were collected from two tertiary referral hospitals. Two experienced radiologists independently reviewed each image and categorized the nodules according to the 2015 American Thyroid Association guideline. Read More

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http://dx.doi.org/10.14366/usg.19069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315296PMC

An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature.

Case Rep Endocrinol 2020 31;2020:2128093. Epub 2020 Mar 31.

Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, México City 14000, Mexico.

Synchronous parathyroid and papillary thyroid carcinoma are extremely rare. To our knowledge, only 15 cases have been reported in the last four decades. We describe a 50-year-old female without significant past medical or family history and no previous trauma presented with left heel pain that prompted her to seek medical attention. Read More

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http://dx.doi.org/10.1155/2020/2128093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150727PMC

Comparison of different systems of ultrasound (US) risk stratification for malignancy in elderly patients with thyroid nodules. Real world experience.

Endocrine 2020 Apr 14. Epub 2020 Apr 14.

Endocrinology Department, Cesar Milstein Hospital, CABA, Buenos Aires, Argentina.

Purpose: To comparatively assess the performance of three sonographic classification systems, American Thyroid Association (ATA), the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS), and American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology (ACE)/Associazione Medici Endocrinologi (AME) in identifying malignant nodules in an elderly population.

Methods: Cross-sectional study of patients referred for fine needle aspiration biopsy in an academic center for the elderly. One nodule/patient was considered. Read More

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http://dx.doi.org/10.1007/s12020-020-02295-4DOI Listing

Identifying predictive factors for efficacy in high intensity focused ultrasound (HIFU) ablation of benign thyroid nodules - a retrospective analysis.

Int J Hyperthermia 2020 ;37(1):324-331

Department of Radiology, The University of Hong Kong, Hong Kong SAR, China.

Since it is unclear whether clinical parameters can independently predict the subsequent treatment response following high intensity focused ultrasound (HIFU) ablation of benign thyroid nodules, we aimed to examine clinical factors that may independently predict 12-month efficacy after HIFU treatment. One hundred and forty patients who had single ablation were categorized into two groups, those with 12-month nodule shrinkage above the median (Group I,  = 70) and with shrinkage below or equal to the median (Group II,  = 70). Baseline characteristics, treatment parameters, percentage change in serum TSH, Free thyroxine (FT4) and thyroglobulin (Tg) from baseline to Day 4 and appearance of microbubbles (hyperechoic marks (HEMs)) during treatment were compared between groups. Read More

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http://dx.doi.org/10.1080/02656736.2020.1747646DOI Listing
January 2020

Computer-aided diagnostic system for thyroid nodule sonographic evaluation outperforms the specificity of less experienced examiners.

J Ultrasound 2020 Jun 3;23(2):169-174. Epub 2020 Apr 3.

Department of Radiological, Oncological, and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.

Purpose: Computer-aided diagnosis (CAD) may improve interobserver agreement in the risk stratification of thyroid nodules. This study aims to evaluate the performance of the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) classification as estimated by an expert radiologist, a senior resident, a medical student, and a CAD system, as well as the interobserver agreement among them.

Methods: Between July 2016 and 2018, 107 nodules (size 5-40 mm, 27 malignant) were classified according to the K-TIRADS by an expert radiologist and CAD software. Read More

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http://dx.doi.org/10.1007/s40477-020-00453-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242558PMC

Qualitative analysis of contrast-enhanced ultrasound in the diagnosis of small, TR3-5 benign and malignant thyroid nodules measuring ≤1 cm.

Br J Radiol 2020 Jul 9;93(1111):20190923. Epub 2020 Apr 9.

Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Objective: To evaluate the performance of contrast-enhanced ultrasound in the diagnosis of small, solid, TR3-5 benign and malignant thyroid nodules (≤1 cm).

Methods: From January 2016 to March 2018, 185 thyroid nodules from 154 patients who underwent contrast enhanced ultrasound (CEUS) and fine-needle aspiration or thyroidectomy in Shanghai General Hospital were included. The χ test was used to compare the CEUS characteristics of benign and malignant thyroid nodules, and the CEUS features of malignant nodules assigned scores. Read More

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http://dx.doi.org/10.1259/bjr.20190923DOI Listing

Intranodular Vascularity May Be Useful in Predicting Malignancy in Thyroid Nodules with the Intermediate Suspicion Pattern of the 2015 American Thyroid Association Guidelines.

Ultrasound Med Biol 2020 Jun 30;46(6):1373-1379. Epub 2020 Mar 30.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

The aim of the study described here was to determine whether vascularity patterns on Doppler ultrasonography (US) differentiate benign and malignant thyroid nodules with the intermediate suspicion pattern based on the 2015 American Thyroid Association guidelines. A total of 411 benign or malignant thyroid nodules from 406 patients with intermediate-suspicion US features were retrospectively collected. Univariate and multivariate logistic regression analyses with the generalized estimating equation were used to identify factors predicting malignancy, and odds ratios with 95% confidence intervals were calculated. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.02.016DOI Listing
June 2020
2.214 Impact Factor

Diagnostic Efficacy and Safety of Core Needle Biopsy as a First-Line Diagnostic Method for Thyroid Nodules: A Prospective Cohort Study.

Thyroid 2020 Apr 28. Epub 2020 Apr 28.

Department of Pathology, Ewha Clinical Laboratory, Seoul, Korea.

The diagnostic role of ultrasonography (US)-guided core needle biopsy (CNB) as a first-line diagnostic method for thyroid nodules remains controversial. This study was performed to determine the diagnostic efficacy and safety of CNB as a first-line diagnostic method for thyroid nodules. From February 2016 to January 2018, CNB was prospectively performed by an experienced radiologist in all consecutive patients with thyroid nodules indicated for fine-needle aspiration (FNA). Read More

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http://dx.doi.org/10.1089/thy.2019.0444DOI Listing

TI-RADS Diagnostic Performance: Which Algorithm is Superior and How Elastography and 4D Vascularity Improve the Malignancy Risk Assessment.

Diagnostics (Basel) 2020 Mar 26;10(4). Epub 2020 Mar 26.

2nd Department of Internal Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Given the increased prevalence of thyroid nodules in the general population (~50%), the real challenge resides in correctly recognizing the suspicious ones. This study proposes to compare four important Thyroid Imaging and Reporting Data Systems (TI-RADS) and evaluate the contribution of elastography and 4D Color Doppler assessment of vascularity in estimating the risk of malignancy. In the study, 133 nodules with histopathological examination were included. Read More

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http://dx.doi.org/10.3390/diagnostics10040180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235757PMC