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    Atypical adenoma of the thyroid diagnosed as anaplastic cancer by cytopathology.
    Diagn Cytopathol 2017 May 22. Epub 2017 May 22.
    Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
    Atypical adenoma of the thyroid is a rare form of tumor, and its accurate diagnosis prior to surgical resection is difficult as the histological and pathological morphologies are very similar to those of anaplastic thyroid carcinoma (ATC), and its anaplastic transformation remains to be elucidated. We reported a case of a 75-year-old female with a thyroid isthmus nodule diagnosed repeatedly by FNAC as anaplastic carcinoma. Both the first and second FNAC specimen slides showed a large number of scattered or aggregated atypical cells consisting of large, pleomorphic nuclei with irregular membranes, chromatin clumps and prominent nucleoli. Read More

    Vocal cord paresis following single-session high intensity focused ablation (HIFU) treatment of benign thyroid nodules - incidence and risk factors.
    Int J Hyperthermia 2017 May 24:1-27. Epub 2017 May 24.
    c Department of Radiology , The University of Hong Kong , Hong Kong SAR, China.
    Background: Vocal cord paresis (VCP) may occur following high intensity focused ultrasound (HIFU) of thyroid nodules. We hypothesized its occurrence relates to the distance of the focus point (FP) of the HIFU beams from the recurrent laryngeal nerve (RLN) and the thermal power that this point received. Their relationships were examined. Read More

    High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function.
    Int J Hyperthermia 2017 Apr 24:1-7. Epub 2017 Apr 24.
    c Department of Radiology , The University of Hong Kong , Hong Kong SAR , PR China.
    Background: High intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. However, its effect on underlying thyroid function remains unknown. We aimed to evaluate the 6 months changes in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) after HIFU treatment. Read More

    Radiofrequency ablation of benign thyroid nodules: depicting early sign of regrowth by calculating vital volume.
    Int J Hyperthermia 2017 Apr 10:1-6. Epub 2017 Apr 10.
    e Department of Radiology , Konkuk University Medical Center, Konkuk University School of Medicine, Research Institute of Medical Science , Seoul , Republic of Korea.
    Objective: We evaluated long-term follow-up results of radiofrequency ablation of benign thyroid nodules to analyse the role of marginal vital tissue on nodule regrowth.

    Materials And Methods: We reviewed the medical records of 54 patients who underwent radiofrequency ablation between June 2008 and November 2013 with pressure symptoms, and/or cosmetic problems. All patients were followed up at least 12 months on three occasions. Read More

    Single-session high intensity focussed ablation (HIFU) versus open cervical hemithyroidectomy for benign thyroid nodule: analysis on early efficacy, safety and voice quality.
    Int J Hyperthermia 2017 Mar 24:1-7. Epub 2017 Mar 24.
    c Division of Speech and Hearing Sciences , The University of Hong Kong , Hong Kong , Hong Kong, China.
    Background: High intensity focussed ultrasound (HIFU) is a promising non-surgical treatment for symptomatic benign thyroid nodule. We aimed to compare early efficacy, safety and voice quality between HIFU ablation and open thyroidectomy.

    Methods: Consecutive patients who underwent single-session HIFU ablation or a hemithyroidectomy for symptomatic benign thyroid nodule were included. Read More

    Ultrasonographic Assessment of Differential Diagnosis Between Degenerating Cystic Thyroid Nodules and Papillary Thyroid Microcarcinomas.
    World J Surg 2017 May 24. Epub 2017 May 24.
    Department of Ultrasonography, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
    Purpose: To enhance the diagnostic accuracy of conventional ultrasonography in differentiating papillary thyroid microcarcinomas (PTMCs) from degenerating cystic thyroid nodules mimicking malignancy (under 10 mm in diameter).

    Methods: A retrospective analysis of hypoechoic thyroid nodules under 10 mm between 162 cases of degenerating cystic thyroid nodules confirmed by ultrasound-guided fine-needle aspiration (US-FNA) and 150 cases of PTMCs confirmed by both US-FNA and postoperative pathology were performed in the aspects of shape, margin, calcification, and vascularity.

    Results: Significant differences were observed in the aspects of shape, rim calcification, and vascularity (P < 0. Read More

    Multiplex PCR approach to simultaneously identify several mutations in fine needle cytology thyroid samples.
    Oncotarget 2017 May 7. Epub 2017 May 7.
    Functional Genomics Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italia.
    The most frequent initial manifestation of thyroid cancer is the appearance of a nodule. More than 20% of the general population has a palpable thyroid nodule and the percentage rises to 70% based on ultrasound identification. In 95% of cases the nodule is simply a hyperplastic or benign lesion. Read More

    A nodule on the scalp as the first sign of extranodal disease in medullary thyroid carcinoma.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Department of Dermatology, Hospital Universitari de Bellvitge, Barcelona, Spain.
    Medullary carcinoma of the thyroid gland accounts for only 5-10% of thyroid carcinomas. Also, metastases to the skin of malignant tumors are infrequently (2-9% of patients). In the case herein reported in a 64-year old woman, a metastatic nodule on the scalp was the presenting clinical manifestation of a medullary thyroid carcinoma. Read More

    ROLE OF MOLECULAR MARKERS IN THYROID NODULE MANAGEMENT: THEN AND NOW.
    Endocr Pract 2017 May 23. Epub 2017 May 23.
    From: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
    Objective: To describe the evolution and clinical utility of molecular testing for thyroid nodules and cancer achieved over the last two decades.

    Methods: Scientific reports on thyroid cancer genetics and molecular diagnostics in thyroid nodules.

    Results: Over the last two decades, our understanding of the genetic mechanisms of thyroid cancer has dramatically expanded, such that most thyroid cancers now have known gene driver events. Read More

    REFERRAL OF OLDER THYROID CANCER PATIENTS TO A HIGH-VOLUME SURGEON: RESULTS OF A MULTIDISCIPLINARY PHYSICIAN SURVEY.
    Endocr Pract 2017 May 23. Epub 2017 May 23.
    From: 1 Division of Metabolism, Endocrinology and Diabetes; Department of Internal Medicine, University of Michigan.
    Objective: Surgical outcomes of thyroid cancer patients are improved with high-volume surgeons. However, age disparities in referral to specialist surgical centers still exist. The factors that influence decision-making regarding referral of older thyroid cancer patients to high-volume surgeons remain unknown. Read More

    Expression of claudin 1, 4 and 7 in thyroid neoplasms.
    Oncol Lett 2017 May 27;13(5):3722-3726. Epub 2017 Mar 27.
    Department of Pathology, University of Health Sciences, Antalya Education and Research Hospital, Antalya 07050, Turkey.
    The distinction of thyroid carcinoma from benign thyroid neoplasm, as well as the subtyping of papillary carcinoma (PC) and follicular carcinoma (FC), may be performed histopathologically in the majority of cases. However, in certain cases, it is difficult to histopathologically distinguish between PC and FC, as well as follicular adenoma (FA), FC and the dominant nodule of multinodular goiter (MNG-DN). The present study aimed to determine the roles of the expression levels of the tight junction proteins claudin 1, 4 and 7 in the differential diagnosis of PC, FC, FA, MNG-DN, medullary carcinoma (MC) and anaplastic carcinoma (AC). Read More

    US Elastography Using Carotid Artery Pulsation May Increase the Diagnostic Accuracy for Thyroid Nodules with US-Pathology Discordance.
    Ultrasound Med Biol 2017 May 17. Epub 2017 May 17.
    Department of Radiology, Ajou University School of Medicine, Wonchon-Dong, Yeongtong-Gu, Suwon, Korea.
    This study evaluated the diagnostic performance of ultrasound elastography (USE) using carotid arterial pulsation and determined the reproducibility of USE for thyroid nodules. A total of 148 patients with 173 thyroid nodules participated. The mean elasticity contrast index (ECI) was significantly higher in malignant nodules (3. Read More

    Incidental Thyroid Nodule Noted on Intra-arterial Hepatic MAA Scan Before 90Y-SIRT.
    Clin Nucl Med 2017 May 19. Epub 2017 May 19.
    From the *Department of Nuclear Medicine, Kaohsiung Veterans General Hospital; †Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung; and ‡National Yang-Ming University, School of Medicine, Taipei, Taiwan.
    We report a case of a 61-year-old man who had recurrent hepatocellular carcinoma admitted for series evaluation before Y selective internal radiotherapy (SIRT). Intra-arterial hepatic Tc macroaggregated albumin scan before Y-SIRT revealed a 2.7-cm incidental low-density thyroid nodule with hot uptake. Read More

    Using Ultrasonography to Evaluate the Relationship between Capsular Invasion or Extracapsular Extension and Lymph Node Metastasis in Papillary Thyroid Carcinomas.
    Chin Med J (Engl) 2017 Jun;130(11):1309-1313
    Department of Cardiology, Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
    Background: Previous studies have demonstrated that ultrasonography is the recommended imaging modality for preoperative staging of papillary thyroid carcinomas (PTCs). However, only a few studies have kept watch on preoperative evaluation of capsular invasion (CI) or extracapsular extension (ECE) and cervical lymph node metastasis using preoperative ultrasonography. This study aimed to investigate the relationship between the CI or ECE and the cervical lymph node metastasis in PTCs using preoperative ultrasonography and postoperative pathology in Chinese patients. Read More

    MALDI-MSI Analysis of Cytological Smears: The Study of Thyroid Cancer.
    Methods Mol Biol 2017 ;1618:37-47
    Department of Medicine and Surgery, Proteomics and Metabolomics Unit, University of Milano-Bicocca, Monza, 20900, Italy.
    Fine needle aspiration (FNA) biopsies are the current gold-standard for the preoperative evaluation of thyroid nodules. However, a significant number of them (15-30%) are unable to be affirmatively diagnosed and are given an "indeterminate for malignancy" final report, meaning that the malignant nature of the thyroid nodule remains unknown and the recommended therapeutic approach is total thyroidectomy. Furthermore, cytomorphological evaluation of biopsies taken post-surgery indicates that approximately 80% of nodules within this group of patients are in fact benign, and the total thyroidectomy unwarranted. Read More

    Hashimoto's thyroiditis associated with thyroid adenoma with Hürthle cells - case report.
    Rom J Morphol Embryol 2017 ;58(1):241-248
    Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). Read More

    High intensity focused ultrasound (HIFU) ablation of benign thyroid nodules - a systematic review.
    J Ther Ultrasound 2017 17;5:11. Epub 2017 May 17.
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR China.
    Background: With an increasing number of imaging studies being done nowadays, the number of incidentally discovered thyroid nodules is expected to rise. Although many of these nodules are small and benign in nature, some do grow and may cause pressure and/or thyrotoxic symptoms. Surgical resection has traditionally been recommended for symptomatic nodules but is associated with risk of hypothyroidism, bleeding, infection, and nerve damage. Read More

    Update on the role of ultrasound guided radiofrequency ablation for thyroid nodule treatment.
    Int J Surg 2017 May;41 Suppl 1:S82-S93
    Department of Surgical Sciences, Policlinico Umberto I, University Sapienza, Roma, 00185, Viale Regina Elena 324, Italy. Electronic address:
    Thyroid nodules can be frequently detected in general population, most of them are benign, however malignant cases are rising in the past decades. Ultrasound (US) is the most common imaging modality to assess thyroid nodular lesions, plan patient work-up and guide minimally invasive treatment. The present review paper has been researched to evaluate the current status of radiofrequency ablation (RFA) treatment in order to evaluate indications, techniques, complications, limitations and outcome assessment in benign solid, partially cystic nodules and recurrent malignant nodules. Read More

    The surgical approach to nodule Thyr 3-4 after the 2.2014 NCCN and 2015 ATA guidelines.
    Int J Surg 2017 May;41 Suppl 1:S21-S25
    Department of Clinical and Experimental Medicine, University Hospital of Parma, Italy. Electronic address:
    Background: The incidence of palpables thyroid nodules in general population is 5% and the prevalence of non -palpable nodules is higher (35-60%) in the endemic goiter area. In the last years the new guidelines and new classification related to thyroid nodule have changed the indication to treat it.

    Material And Method: We analyzed the patients treated from January 2013 to June 2016 for Thyr 3 and Thyr 4 thyroid nodule sec. Read More

    [Evaluation of a thyroid nodule].
    Laeknabladid 2017 Januar;102(1):23-27
    Thyroid nodules are common and their incidence has increased due to various factors. Systematic approach to the work-up of thyroid nodules is necessary to decrease overdiagnosis as well as over treatment. Applying the trifecta of history, physicial examination and high-resolution ultrasound (HRUS) as well as fine needle aspiration biopsy (FNAB) with added TSH measurement is important in the work-up. Read More

    Concordant clear cell "mesonephric" carcinoma of the bladder and lung adenocarcinoma with clear cell features - multiple primaries versus metastatic neoplasms: a case report.
    J Med Case Rep 2017 May 12;11(1):133. Epub 2017 May 12.
    Department of Pathology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
    Background: Clear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies.

    Case Presentation: Our patient was a 59-year-old African American woman who presented with hematuria. Read More

    Korean Thyroid Imaging Reporting and Data System features of follicular thyroid adenoma and carcinoma: a single-center study.
    Ultrasonography 2017 Apr 13. Epub 2017 Apr 13.
    Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea.
    Purpose: This study aimed to assess the diagnostic efficacy of Korean Thyroid Imaging Reporting and Data System (K-TIRADS) features for distinguishing follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC).

    Methods: From January 2013 to July 2016, 46 follicular neoplasms in 45 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery were included. The US features of each thyroid nodule were retrospectively evaluated by a single radiologist using a picture archiving and communication system. Read More

    Comparison of risk of malignancy in a subgroup with atypia of undetermined significance/follicular lesion of undetermined significance: A meta-analysis.
    Head Neck 2017 May 11. Epub 2017 May 11.
    Department of Otorhinolaryngology Head Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea.
    Background: As heterogeneous findings are included in the atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS) category, differing risks of malignancy in subgroups have been reported in several articles.

    Methods: We performed a meta-analysis of full-text publications written in English found in the Embase and PubMed databases.

    Results: The 4-tiered subgroup proportion meta-analysis showed that the 95% confidence interval (95% CI) of the risk of malignancy in the cellular atypia group did not overlap with the other 3 subgroups and demonstrated a significant difference. Read More

    Multiple malignant epithelioid mesotheliomas of the liver and greater omentum: a case report and review of the literature.
    Surg Case Rep 2017 Dec 10;3(1):66. Epub 2017 May 10.
    Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.
    Background: Malignant mesothelioma commonly arises from the pleura, but can also arise from the peritoneum, pericardium, and tunica vaginalis testis. However, malignant mesothelioma of the liver is extremely rare and coexistence with malignant mesothelioma of the greater omentum has not been described in the literature. In this case report, we present a case of multiple malignant mesothelioma of the liver and greater omentum. Read More

    Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review.
    Acta Cytol 2017 May 11. Epub 2017 May 11.
    Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
    Background: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare.

    Case: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. Read More

    Analysis of radioiodine therapy and prognostic factors of differentiated thyroid cancer patients with pulmonary metastasis: An 8-year retrospective study.
    Medicine (Baltimore) 2017 May;96(19):e6809
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road, Tianjin, People's Republic of China.
    To assess the efficacy of radioiodine therapy (RIT) and investigate the prognostic factors for patients with pulmonary metastasis secondary to differentiated thyroid carcinoma (DTC) through a retrospective study. A total of 80 patients with radioactive iodine-131 (I)-avid pulmonary metastasis from DTC treated with I from 2007 to 2014 at our institution entered the study. Treatment response was mainly measured by two parameters: serum thyroglobulin (Tg) levels and post-therapeutic I whole-body scan (WBS). Read More

    Elevated serum growth differentiation factor 15 levels are associated with thyroid nodules in type 2 diabetes aged over 60 years.
    Oncotarget 2017 Apr 21. Epub 2017 Apr 21.
    Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
    In order to investigate whether serum growth differentiation factor 15 is associated with thyroid nodules in type 2 diabetes. We recruited 723 type 2 diabetic patients aged over 30 years who attended the clinic of Endocrinology of Xinhua Hospital from January 2013 to January 2015. Thyroid nodule was diagnosed by thyroid ultrasonographic examination. Read More

    The thyroid cancer policy model: A mathematical simulation model of papillary thyroid carcinoma in The U.S. population.
    PLoS One 2017 8;12(5):e0177068. Epub 2017 May 8.
    Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
    Background: Thyroid cancer affects over ½ million people in the U.S. and the incidence of thyroid cancer has increased worldwide at a rate higher than any other cancer, while survival has remained largely unchanged. Read More

    Robotic thyroidectomy and parathyroidectomy: An initial experience with retroauricular approach.
    Head Neck 2017 May 5. Epub 2017 May 5.
    Division of Otolaryngology, Tulane University School of Medicine, New Orleans, Louisiana.
    Background: New approaches for robotic-assisted thyroidectomy were recently described. The purpose of this study was to present the report of our initial experience using a retroauricular approach for thyroid and parathyroid surgeries.

    Methods: This is a prospective study that was conducted under institutional review board approval and all surgeries were performed by a single surgeon at a North American academic institution. Read More

    Comparison of Mono- and Bipolar Radiofrequency Ablation in Benign Thyroid Disease.
    World J Surg 2017 May 4. Epub 2017 May 4.
    Department of Nuclear Medicine, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
    Purpose: Radiofrequency ablation (RFA) is an approved minimal invasive method for the treatment of benign thyroid nodules. Several experimental, mainly ex vivo animal studies have compared the effectiveness of different RFA procedures in liver tissue. The aim of this retrospective clinical study was to evaluate the difference between monopolar and bipolar RFA in thyroid tissue considering thyroid volume reduction, patient discomfort and ultrasound evaluation. Read More

    Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Thyroid Hormone Levels in Chinese Patients, Could It Be a Risk for Thyroid Nodules?
    Obes Surg 2017 May 3. Epub 2017 May 3.
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
    Objectives: The study aimed to evaluate the changes in thyroid function and the risk of thyroid tumors after Roux-en-Y gastric bypass (RYGB) surgery.

    Materials And Methods: This was a retrospective study of 117 patients with type 2 diabetes (T2D) and obesity who underwent laparoscopic RYGB (LRYGB) and were followed up for 36 months. Thyroids were examined with ultrasonography. Read More

    Diagnostic Value of Acoustic Radiation Force Impulse Quantification in the Differentiation of Benign and Malignant Thyroid Nodules.
    Ultrason Imaging 2017 May 1:161734617706170. Epub 2017 May 1.
    1 Department of Radio-Diagnosis, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India.
    The objective of this study was to evaluate the role of ultrasound elastography using acoustic radiation force impulse (ARFI) quantification in characterizing and differentiating malignant versus benign thyroid nodules. A total of 40 thyroid nodules were evaluated with conventional sonography and ultrasound elastography using ARFI quantification. The final diagnosis was obtained from histologic findings. Read More

    Efficacy and safety of ultrasound-guided percutaneous polidocanol sclerotherapy in benign predominantly cystic thyroid nodules: a prospective study.
    Curr Med Res Opin 2017 May 3:1-12. Epub 2017 May 3.
    a Department of Endocrinology and Metabolism , the First Affiliated Hospital of Wenzhou Medical University , Ouhai District , Wenzhou 325015 , Zhejiang Province , People's Republic of China.
    Objective: To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating of predominantly cystic thyroid nodules.

    Materials And Methods: This prospective study included 111 patients with 122 benign predominantly cystic thyroid nodules inducing pressure symptoms or cosmetic problems. The nodules were randomized to a single aspiration with (n = 61) or without (n = 61) subsequent PPI and followed up after 1, 3, 6 and 12 months. Read More

    A Rare Complication following Thyroid Percutaneous Ethanol Injection: Plummer Adenoma.
    Case Rep Endocrinol 2017 29;2017:1026139. Epub 2017 Mar 29.
    Department of Endocrinology, University Campus Bio-Medico, Rome, Italy.
    Percutaneous ethanol injection (PEI) is a technique used only for benign thyroid nodules, cystic or mixed cystic-solid with a large fluid component. It is a quite low-cost, safe, and outpatient method of treatment. Rare and severe complications have been described after PEI: jugular vein thrombosis and severe ethanol toxic necrosis of the larynx combined with necrotic dermatitis. Read More

    Is ultrasonographically detected nodule diameter concordant with pathological tumor size?
    Int J Surg 2017 Apr 29;42:95-102. Epub 2017 Apr 29.
    Ankara Yildirim Beyazit University, School of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.
    Introduction: We aimed to compare preoperative ultrasonographical and postoperative histopathological diameters of differentiated thyroid cancer (DTC) lesions and investigate possible factors that can predict the discordance between two measurements.

    Methods: Data of patients with histopathologically confirmed DTC were reviewed retrospectively. Nodules evaluated by preoperative US were matched with histopathologically examined nodules. Read More

    Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment.
    Respir Med Case Rep 2017 19;21:121-123. Epub 2017 Apr 19.
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-Ku, Tokyo, 113-8431, Japan.
    Cutaneous adenoid cystic carcinoma (CACC) is an extremely rare neoplasm of head and neck region, and is characterized by propensity for local recurrence and perineural invasion. Late distant metastases occur usually to lungs. Although patients with lung metastases from CACC cannot be cured, long-term survival may be possible due to its slow-growing malignancy. Read More

    Improving Bethesda Reporting in Thyroid Cytology: A Team Effort Goes a Long Way and Still Miles to Go….
    Indian J Endocrinol Metab 2017 Mar-Apr;21(2):277-281
    Department of Pathology, Narayana Health City, Bengaluru, Karnataka, India.
    Context: Fine-needle aspiration cytology is the first step in evaluation of thyroid nodules. Although the Bethesda classification for reporting thyroid cytology has been purported that this uniformity in reporting cytology thereby facilitating clinical decision-making, there are also studies indicating that the reporting percentage and the rates of malignancy in each category vary considerably from center to center making the clinical decision more difficult.

    Aim And Materials And Methods: We looked at our retrospective cytology and histopathology data of thyroid nodules operated between 2012 and 2014 and then prospectively collected data during 2015-2016. Read More

    An unusual case of adult-onset multi-systemic Langerhans cell histiocytosis with perianal and incident thyroid involvement.
    Endocrinol Diabetes Metab Case Rep 2017 2;2017. Epub 2017 Feb 2.
    Department of Endocrinology and Metabolism.
    Summary: Langerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal. Herein, we report a rare case of adult-onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental finding of subsequent thyroid gland involvement in the follow-up period. The patient with a history of perianal LCH treated with surgical excision and local radiotherapy was referred to our Endocrinology Department upon detection of hypermetabolic nodular lesions in the left lateral lobe of thyroid gland on positron emission tomography-computed tomography (PET/CT) scan in the nineth month of follow-up. Read More

    Innovative Techniques for Image-Guided Ablation of Benign Thyroid Nodules: Combined Ethanol and Radiofrequency Ablation.
    Korean J Radiol 2017 May-Jun;18(3):461-469. Epub 2017 Apr 3.
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
    In the treatment of benign thyroid nodules, ethanol ablation (EA), and radiofrequency ablation (RFA) have been suggested for cystic and solid thyroid nodules, respectively. Although combining these ablation techniques may be effective, no guidelines for or reviews of the combination have been published. Currently, there are three ways of combining EA and RFA: additional RFA is effective for treatment of incompletely resolved symptoms and solid residual portions of a thyroid nodule after EA. Read More

    [Pleuropulmonary metastases originating from extra-thoracic neoplasia].
    Pan Afr Med J 2017 30;26:44. Epub 2017 Jan 30.
    Service de Pneumologie, Laboratoire de Recherche Pneumologie-Cardiologie-Immunopathologie et Métabolisme, Université Qadi Ayyad, Marrakech, Maroc.
    The lungs receive the entire venous drainage of the body. This explains the high incidence of pleuropulmonary metastases originating from several cancers. The goal of this is to study the clinical manifestations of pleuro-pulmonary metastases originating from extra-thoracic cancers. Read More

    Bethesda Made It Clearer: A Review of 542 Patients in a Single Institution.
    Oncol Res Treat 2017 21;40(5):277-280. Epub 2017 Mar 21.
    Background: It is essential to interpret fine needle aspiration biopsy (FNAB) material correctly to create a common language among pathologists and surgeons, leading to a uniform approach to thyroid nodule management. We aimed to compare FNAB reports of patients at our institution who were treated with total thyroidectomy, before and after the Bethesda classification system.

    Patients And Methods: Patients who underwent total thyroidectomy for thyroid nodules are reviewed. Read More

    Fine-Needle Aspiration Versus Frozen Section in the Evaluation of Malignant Thyroid Nodules in Patients With the Diagnosis of Suspicious for Malignancy or Malignancy by Fine-Needle Aspiration.
    Arch Pathol Lab Med 2017 May;141(5):684-689
    From the Departments of Pathology (Drs Ye, Chen, and Xu, and Ms Li), Surgery (Drs Zhao and Wang), and Ultrasonography (Dr Huang), Second Affiliate Hospital, Zhejiang University, Hangzhou, China; and the Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (Drs Woo, Yang, and Rao, and Mr Yong).
    Context: - The Bethesda System for Reporting Thyroid Cytopathology recommends against the use of intraoperative frozen section (FS) during lobectomy of a thyroid nodule with a fine-needle aspiration (FNA) diagnosis of malignant. Bethesda recommendations for FS in the FNA category of suspicious for malignancy (SFM) is less well-defined. In some institutions in China, FS examination is performed during lobectomy even for FNA-proven malignant cases. Read More

    Aberrant Intrathyroid Tissue: a Report of Intrathyroid Lymph Node Metastasis and a Review of Literature.
    Indian J Surg 2017 Apr 20;79(2):148-152. Epub 2017 Jan 20.
    Department of Surgery, Waikato Hospital, Hamilton, New Zealand.
    Aberrant histological elements have been infrequently reported to exist within the intact thyroid gland. In addition to distant metastases to the thyroid, a number of ectopic tissue rests and unusual cysts have been described within the thyroid gland. In this article, we report the presence of a true intrathyroid lymph node and describe the first reported case of intrathyroid lymph node metastasis of papillary thyroid cancer. Read More

    Consensus statement for use and technical requirements of thyroid ultrasound in endocrinology units.
    Endocrinol Diabetes Nutr 2017 Mar 13;64 Suppl 1:23-30. Epub 2017 Feb 13.
    Departamento de Endocrinología, Clínica Universidad de Navarra, Pamplona, España.
    Thyroid nodule detection has increased with widespread use of ultrasound, which is currently the main tool for detection, monitoring, diagnosis and, in some instances, treatment of thyroid nodules. Knowledge of ultrasound and adequate instruction on its use require a position statement by the scientific societies concerned. The working groups on thyroid cancer and ultrasound techniques of the Spanish Society of Endocrinology and Nutrition have promoted this document, based on a thorough analysis of the current literature, the results of multicenter studies and expert consensus, in order to set the requirements for the best use of ultrasound in clinical practice. Read More

    Characterization of benign thyroid nodules with HyperSPACE (Hyper Spectral Analysis for Characterization in Echography) before and after percutaneous laser ablation: a pilot study.
    Med Ultrason 2017 Apr;19(2):172-178
    Department of Information Engineering (DINFO), University of Florence, Florence, Italy.
    Aims: To evaluate the capability of the HyperSPACE (Hyper SPectral Analysis for Characterization in Echography) method in tissue characterization, in order to provide information for the laser treatment of benign thyroid nodules in respect of conventional B-mode images and elastography.

    Material And Methods: The method, based on the spectral analysis of the raw radiofrequency ultrasonic signal, was applied to characterize the nodule before and after laser treatment. Thirty patients (25 females and 5 males, age between 37 and 81 years) with thyroid benign nodule at cytology (Thyr 2) were evaluated by conventional ultrasonography, elastography, and HyperSPACE, before and after laser ablation. Read More

    Transoral thyroidectomy: advantages and limitations.
    J Endocrinol Invest 2017 Apr 21. Epub 2017 Apr 21.
    Minimally Invasive and Endocrine Division, Department of Surgery, Police General Hospital, Bangkok, Thailand.
    In this opinion paper of the Journal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, "transoral thyroidectomy" (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a benign tumor such as a thyroid cyst or a single- or multi-nodular goiter; (e) Bethesda 3 and/or 4 category and (f) papillary microcarcinoma without the evidence of metastasis. Read More

    Understanding the Risks and Harms of Management of Incidental Thyroid Nodules: A Review.
    JAMA Otolaryngol Head Neck Surg 2017 Apr 20. Epub 2017 Apr 20.
    Department of Radiology, The Ohio State University Wexner Medical Center, Columbus.
    Importance: Incidental thyroid nodules are defined as nodules originally detected in a patient with no thyroid-related clinical symptoms, examination findings, or suspected thyroid disease. Medical imaging for diseases in the neck, chest, and spine is a common source of incidental thyroid nodules. They are easily detected but poorly characterized. Read More

    Importance of cytological subclassification of thyroid nodules with Bethesda category III cytology (AUS/FLUS) into architectural atypia only and nuclear atypia: A prospective study.
    Diagn Cytopathol 2017 Apr 19. Epub 2017 Apr 19.
    Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    Background: The objective of this study was to compare two cytological subcategories of thyroid nodules with Bethesda category III initial cytology.

    Methods: This was a prospective study. All patients with thyroid nodules > 1 cm were eligible and 98 patients with category III cytology were selected. Read More

    The role of molecular diagnostic testing in the management of thyroid nodules.
    Expert Rev Mol Diagn 2017 Jun 28;17(6):567-576. Epub 2017 Apr 28.
    a Department of Surgery , New York Presbyterian-Weill Cornell Medicine , New York , NY , USA.
    Introduction: Fine needle aspiration (FNA) with cytologic examination remains the standard of care for investigation of thyroid nodules. However, as many as 30% of FNA samples are cytologically indeterminate for malignancy, which confounds clinical management. To reduce the burden of repeat diagnostic testing and unnecessary surgery, there has been extensive investigation into molecular markers that can be detected on FNA specimens to more accurately stratify a patient's risk of malignancy. Read More

    Ultrasound is helpful to differentiate Bethesda class III thyroid nodules: A PRISMA-compliant systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Apr;96(16):e6564
    Department of Ultrasound, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
    Background: Fine-needle aspiration (FNA) is the most dependable tool to triage thyroid nodules for medical or surgical management. However, Bethesda class III cytology, namely "follicular lesion of undetermined significance" (FLUS) or "atypia of undetermined significance" (AUS), is a major limitation of the US-FNA in assessing thyroid nodules. As the most important imaging method, ultrasound (US) has a high efficacy in diagnosing thyroid nodules. Read More

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