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    8058 results match your criteria Thyroid Nodule

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    Recurrent Metastatic Medullary Thyroid Carcinoma: A Case of Sustained Response to Prolonged Treatment with Somatostatin Analogues.
    Thyroid 2017 Sep 19. Epub 2017 Sep 19.
    General Hospital of Ciudad Real, Medical Oncology, Ciudad Real, Spain ;
    Background: Medullary thyroid carcinoma (MTC) is a rare disease. Treatment options for recurrent disease are limited. Somatostatin analogues might have a role as anticancer agents agents in MTC, although the evidence is inconclusive. Read More

    Pharyngoesophageal diverticula simulating thyroid nodules: An unusual occurrence with unique features.
    Diagn Cytopathol 2017 Sep 19. Epub 2017 Sep 19.
    Thyroid Cytopathology Partners, Austin, Texas.
    Pharyngoesophageal diverticula (PED) of the Zenker's and Killian-Jamieson types arise in close proximity to the thyroid gland, and may rarely be confused with a thyroid nodule on ultrasonography. In this brief report, we detail the cytologic, clinical, and radiologic findings of three PED that were thought to be thyroid nodules, and were subjected to fine-needle aspiration (FNA). The patients were females with an age range of 51-64 years. Read More

    Cervical soft tissue recurrence of differentiated thyroid carcinoma after thyroidectomy indicates a poor prognosis.
    Int J Surg 2017 Sep 14. Epub 2017 Sep 14.
    Department of Ultrasound, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100730, China. Electronic address:
    Background: We investigated cervical soft tissue recurrence of differentiated thyroid carcinoma (DTC) after thyroidectomy, and these lesions exhibited no evidence that they were lymph nodes (LNs).

    Methods: Between January 2012 and April 2016, consecutive 6308 patients underwent thyroid surgery for DTC at our center. Among them, we encountered 21 patients with recurrent cervical soft tissue lesions, none of whom had previously undergone fine needle aspiration biopsy (FNAB). Read More

    Suggesting the cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A retrospective analysis of atypical and suspicious nodules.
    Cancer 2017 Sep 15. Epub 2017 Sep 15.
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: The term "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) has replaced a subset of follicular variant of papillary thyroid carcinoma due to the indolent behavior of such tumors. NIFTPs are most often classified in an "indeterminate" diagnostic category. In the current study, the authors sought to identify cytologic features helpful in distinguishing NIFTP from other entities in these categories, particularly benign nodules. Read More

    Does Lesion Size Affect the Value of Shear Wave Elastography for Differentiating Between Benign and Malignant Thyroid Nodules?
    J Ultrasound Med 2017 Sep 14. Epub 2017 Sep 14.
    Departments of Ultrasonography and Oncology, Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.
    Objectives: We aimed to investigate the diagnostic performance of shear wave elastography (SWE) combined with conventional ultrasonography (US) for differentiating between benign and malignant thyroid nodules of different sizes.

    Methods: A total of 445 thyroid nodules from 445 patients were divided into 3 groups based on diameter (group 1, ≤ 10 mm; group 2, 10-20 mm; and group 3, > 20 mm). The mean elasticity index of the whole lesion was automatically calculated, and the threshold for differentiation between benign and malignant nodules was constructed by a receiver operating characteristic curve analysis. Read More

    [Fine-needle Aspiration of Thyroid Nodules: Is it Worth Repeating?]
    Acta Med Port 2017 Jun 30;30(6):472-478. Epub 2017 Jun 30.
    IPATIMUP Diagnósticos. Instituto de Patologia e Imunologia Molecular. Universidade do Porto. Porto. Portugal; Departamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
    Introduction: The fine-needle aspiration has a significant role in assessing the malignancy risk of thyroid nodules. There is uncertainty regarding the value of repeat fine-needle aspiration in benign nodules. This study aims to evaluate the concordance of results in consecutive fine-needle aspiration and to study the relevance of repetition in benign results. Read More

    Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results.
    Clin Endocrinol (Oxf) 2017 Sep 12. Epub 2017 Sep 12.
    Department of Radiology, 1 Seoul National University College of Medicine, Seoul, Korea.
    Objective: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP CONTEXT: Recently, it has been proposed that that non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumors, rather than cancer.

    Patients: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20.4±11. Read More

    Surgeon Performed Thyroid Ultrasound - Proving Utility and Credibility in Selecting Patients for Fine Needle Aspiration According to the American Thyroid Association Guidelines. A Retrospective Study of 500 Patients.
    Clin Otolaryngol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Otolaryngology Head and Neck Surgery, Kaplan Medical Center, Hadassah School of Medicine, Hebrew University, Rehovot, Israel.
    Design: Case series with chart review.

    Setting: Single academic center.

    Participants: The data of all patients who underwent surgeon performed ultrasound (SUS(between 7/2009 and 9/2012 was retrospectively reviewed. Read More

    Robot-Assisted Transaxillary Thyroidectomy (RATT): A Series Appraisal of More than 250 Cases from Europe.
    World J Surg 2017 Sep 8. Epub 2017 Sep 8.
    Department of Surgical Pathology, Medical, Molecular and Critical Area, University of Pisa, Via Paradisa 2, Pisa, Italy.
    Background: Robot-assisted transaxillary thyroidectomy (RATT) is widely accepted in Asian countries. However, concerns regarding the balance between its real advantages and safety and cost have been raised by North American authorities. In Europe, assessments have been limited by small numbers since now. Read More

    Diagnostic Efficiency of Quantitative Contrast-Enhanced Ultrasound Indicators for Discriminating Benign From Malignant Solid Thyroid Nodules.
    J Ultrasound Med 2017 Sep 7. Epub 2017 Sep 7.
    Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha, China.
    Objectives: We aimed to determine the most efficient quantitative parameters to establish a contrast-enhanced ultrasound (US) assessment system for distinguishing between benign and malignant thyroid nodules.

    Methods: A total of 167 patients with thyroid solitary nodules had the diagnosis confirmed by surgery or fine-needle aspiration. Quantitative contrast-enhanced US indicators (time to peak, time from peak to one-half, ascend slope, descend slope, peak intensity, and area under the curve [AUC]) were gathered in nodule and perinodule areas. Read More

    Differentiation of the Follicular Variant of Papillary Thyroid Carcinoma From Classic Papillary Thyroid Carcinoma: An Ultrasound Analysis and Complement to Fine-Needle Aspiration Cytology.
    J Ultrasound Med 2017 Sep 7. Epub 2017 Sep 7.
    Departments of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan Hsien, Taiwan.
    Objectives: It is difficult to establish a diagnosis of the follicular variant of papillary thyroid carcinoma (PTC) using fine-needle aspiration cytology (FNAC). Preoperative features on ultrasound (US) imaging are different between follicular PTC and classic PTC. This study developed a risk score system to differentiate follicular PTC from classic PTC and to correlate the risk score of follicular PTC with its FNAC categories and pathologic features. Read More

    Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer.
    Nucl Med Mol Imaging 2017 Sep 16;51(3):274-276. Epub 2016 May 16.
    Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, 2301 Erwin Rd, Box 3949, Durham, NC 27710 USA.
    Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also exhibited increased F-18 NaF activity in soft tissues. The first patient exhibited multiple F-18 NaF avid enlarged retroperitoneal and pelvic lymph nodes on consecutive PET/CT scans. Read More

    Clinical Parameter for Deciding the BRAFV600E Mutation Test in Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Thyroid Nodules: US Features According to TIRADS.
    Ultrasound Q 2017 Sep 4. Epub 2017 Sep 4.
    Department of Radiology, Yonsei University College of Medicine, Research Institute of Radiological Science, Severance Hospital, Seoul, Korea.
    This study aimed to investigate the usefulness of a thyroid imaging reporting and data system (TIRADS) to select thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytology for additional BRAF mutation testing. Three hundred three thyroid nodules were included. Statistical analysis was performed at both patient and nodule levels according to BRAF mutation positivity and clinical factors. Read More

    Robot-assisted thyroidectomy using a gasless, transaxillary approach for the management of thyroid lesions: Indian experience.
    J Minim Access Surg 2017 Oct-Dec;13(4):280-285
    Manipal Comprehensive Cancer Center, Manipal Hospital, Bengaluru, Karnataka, India.
    Aim: Since last decades, more and more thyroidectomies have been performed by the minimally invasive method. Compared to conventional thyroidectomy, minimally invasive thyroidectomy has a superior cosmetic result. However, the outcome depends, in a large extent, on the skill of the operator and the learning curve is relatively long. Read More

    Unusual presentations of Carney Complex in patient with a novel PRKAR1A mutation.
    Neuro Endocrinol Lett 2017 Aug 5;38(4):248-254. Epub 2017 Aug 5.
    Hacettepe University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.
    Carney Complex (CNC) is a multiple neoplasia syndrome characterized by skin tumors and pigmented lesions, myxomas, and various endocrine tumors. The aim of this case report was to describe a case of CNC with a novel PRKAR1A mutation. A man aged 46 years with a medical history of surgery for cardiac myxomas at the age of 39 was admitted to our hospital because of four newly-developed heart masses. Read More

    A Cervical Schwannoma Masquerading as a Thyroid Nodule.
    Eur Thyroid J 2017 Jul 21;6(4):216-220. Epub 2017 Jan 21.
    Division of Endocrinology and Metabolism, Harbor-UCLA Medical Center, Torrance, CA, USA.
    Background: We present a case of a cervical schwannoma, likely originating from the pharyngeal plexus of the vagal nerve. The lesion masqueraded as a thyroid nodule and magnetic resonance imaging (MRI) assisted in preoperative diagnosis. We review the radiographic characteristics of nerve sheath tumors on MRI as well as the diagnostic cytologic stains which can enhance the possibility of a correct preoperative diagnosis. Read More

    Thyroid Nodule Diagnostic Markers in the Face of the New Diagnosis, NIFT-P: Time for a Reset?
    Thyroid 2017 Aug 31. Epub 2017 Aug 31.
    Johns Hopkins Hospital and Health System, 23236, Endocrine Surgery, Department of Surgery, Baltimore, Maryland, United States ;
    Current thyroid molecular tests are specifically designed for the differential diagnosis of nodules with indeterminate or suspicious fine needle aspiration (FNA) cytology. However, their clinical validity faces challenges from both variation among institutions in cancer prevalence and, most recently, the new category of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P). The latter diagnosis was previously classified as malignant. Read More

    Prevalence of thyroid nodules and their associated clinical parameters: a large-scale, multicenter-based health checkup study.
    Korean J Intern Med 2017 Jul 7. Epub 2017 Jul 7.
    Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
    Background/aims: We evaluated the prevalence and characteristics of thyroid nodules detected by thyroid ultrasound (US) at health checkups and the associated clinical parameters.

    Methods: A total of 72,319 subjects who underwent thyroid US at three health checkup centers in Korea from January 2004 to December 2010 were included in this study. The correlations between the presence of thyroid nodules and other clinical parameters were analyzed. Read More

    Langerhans cell histiocytosis of the thyroid complicated by papillary thyroid carcinoma: A case report and brief literature review.
    Medicine (Baltimore) 2017 Sep;96(35):e7954
    aDepartment of General Surgery bDepartment of Endocrinology cDepartment of Nuclear Medicine dDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Rationale: Langerhans cell histiocytosis (LCH) involves mainly the skin and bone and rarely the thyroid. Meanwhile, papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Both LCH and PTC could make the thyroid enlarged and hypermetabolic. Read More

    US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules.
    Endocr J 2017 Aug 29. Epub 2017 Aug 29.
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University; Suzhou 215006 China.
    The aim of this study was to define the effectiveness and safety of ultrasound(US)-guided percutaneous microwave ablation(MWA) for benign thyroid nodules with one session treatment. A total 121 benign thyroid nodules in 100 euthyroid patients underwent MWA in one medical center between August 2014 and December 2015. MWA was performed with an internally cooled antenna under local anesthesia. Read More

    Ectopic Intrathyroidal Thymic Tissue Mimicking Thyroid Nodules in Children.
    J Ultrasound Med 2017 Aug 29. Epub 2017 Aug 29.
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Ectopic intrathyroidal thymic tissue is a benign lesion of nonthyroid origin occasionally found in the pediatric thyroid gland. Accurate diagnosis of such lesions is critical to avoid unnecessary biopsy or surgery. Twelve children referred to our center for the concern of thyroid nodules were found to have intrathyroidal thymic tissue. Read More

    Ultrasound-guided microwave ablation in the treatment of benign thyroid nodules in 435 patients.
    Exp Biol Med (Maywood) 2017 Jan 1:1535370217727477. Epub 2017 Jan 1.
    Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
    The objective of the present study was to investigate the effectiveness and safety of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules. A total of 474 benign thyroid nodules in 435 patients who underwent ultrasound-guided microwave ablation from September 2012 to August 2015 were included. Nodule volume and thyroid function were measured before treatment and at 1, 3, 6, and 12 months and subsequently after every 6 months. Read More

    Multinodular goiter: A study of malignancy risk in nondominant nodules.
    Ear Nose Throat J 2017 Aug;96(8):336-342
    Department of Otolaryngology-Head and Neck Surgery, National University Hospital, 5 Lower Kent Ridge Rd., Singapore 119074.
    The long-standing belief that multinodular goiters are associated with a lower risk of developing into carcinoma has been challenged by the results of some recent studies. In addition, we have noticed in our practice that a sizable proportion of cancers have been arising from nondominant nodules. We performed a retrospective study of 223 cases to determine (1) the incidence of carcinoma in multinodular goiters that required surgical management in our local, predominantly Asian population and (2) the incidence of carcinoma arising from nondominant nodules. Read More

    2D-Shear Wave Elastography in the Evaluation of Parathyroid Lesions in Patients with Hyperparathyroidism.
    Int J Endocrinol 2017 6;2017:9092120. Epub 2017 Aug 6.
    Department of Endocrinology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
    Background And Aims: 2D-shear wave elastography (2D-SWE) is a relatively new elastographic technique. The aim of the present study is to determine the values of the elasticity indexes (EI) measured by 2D-SWE in parathyroid benign lesions (adenomas or hyperplasia) and to establish if this investigation is helpful for the preoperative identification of the parathyroid adenoma.

    Material And Methods: The study groups were represented by 22 patients with primary or tertiary hyperparathyroidism, diagnosed by specific tests, and 43 healthy controls, in whom the thyroid parenchyma was evaluated, in order to compare the EI of the thyroid tissue with those of the parathyroid lesions. Read More

    Further Investigation on High-intensity Focused Ultrasound (HIFU) Treatment for Thyroid Nodules: Effectiveness Related to Baseline Volumes.
    Acad Radiol 2017 Aug 23. Epub 2017 Aug 23.
    Department of Nuclear Medicine, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
    Rationale And Objectives: Several minimally invasive thermal techniques have been developed for the treatment of benign thyroid nodules. A new technique for this indication is high-intensity focused ultrasound (HIFU). The aim of this study was to assess effectiveness in varying preablative nodule volumes and whether outcome patterns that were reported during studies with other thermal ablative procedures for thyroid nodule ablation would also apply to HIFU. Read More

    [Clinical and pathological differences between papillary thyroid carcinoma with Graves' disease and papillary thyroid carcinoma with Hashimoto's thyroiditis].
    Zhonghua Yi Xue Za Zhi 2017 Aug;97(32):2491-2495
    Department of Vascular & Thyroid Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
    Objective: To explore the clinical and pathological differences between papillary thyroid carcinoma (PTC) with Graves' disease (GD) and PTC with Hashimoto's thyroiditis (HT). Methods: A total of 33 PTC patients with GD and 132 PTC patients with HT in the First Affiliated Hospital of China Medical University from January 2009 to December 2015 were enrolled. The clinical and histopathological data were analyzed. Read More

    Advantages of Routine Ultrasound Combined With Contrast-Enhanced Ultrasound in Diagnosing Papillary Thyroid Carcinoma.
    Ultrasound Q 2017 Sep;33(3):213-218
    *Department of Ultrasound, Shaanxi Provincial Cancer Hospital Affiliated to Medical School, Xi'an Jiaotong University, Xi'an; †Department of Ultrasound, Yan'an University Affiliated Hospital, Yan'an; and ‡Department of Orthopaedics, Hong Hui Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
    This study aimed to evaluate the advantages of routine ultrasound (US), contrast-enhanced US (CEUS), and the combination of these 2 methods in diagnosing papillary thyroid carcinoma (PTC). We subjected 89 patients with calcified thyroid nodules to conventional US and CEUS and then retrospectively analyzed the US and CEUS features of 89 patients with single, solid PTC. On this basis, we then evaluated the ability of US, CEUS, and their combination to diagnose PTC. Read More

    Cost-effectiveness of Gene Expression Classifier Testing of Indeterminate Thyroid Nodules Utilizing a Real Cohort Comparator.
    Otolaryngol Head Neck Surg 2017 Aug 1:194599817725709. Epub 2017 Aug 1.
    1 Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, West Virginia, USA.
    Objective To predict the cost-effectiveness of implementing routine gene expression classifier testing for thyroid nodules with indeterminate fine-needle aspiration cytology, by utilizing a real cohort of patients as a comparator. Study Design Cost-effectiveness analysis of a retrospective cohort compared with a simulated cohort. Setting Tertiary academic medical center. Read More

    Importance of FNA Technique for Decreasing Non-diagnostic Rates in Thyroid Nodules.
    Head Neck Pathol 2017 Aug 17. Epub 2017 Aug 17.
    Division of Otolaryngology - Head and Neck Surgery, The George Washington University, Washington, DC, USA.
    To identify potential interventions that may lower the high non-diagnostic rates associated with ultrasound guided (US) fine needle aspiration (FNA) biopsy of the thyroid nodule. A case series of 164 thyroid nodule US-guided FNA was identified retrospectively. The following variables were analyzed in regards to diagnostic and non-diagnostic sampling: patient age, gender, size of nodule, biopsy technique (capillary vs. Read More

    All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis.
    PLoS One 2017 17;12(8):e0182835. Epub 2017 Aug 17.
    Department of Endocrine and Metabolism, Qilu Hospital, Shandong University, Jinan, China.
    Recently, diagnoses of radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) have become more common; prognosis is poor. It has been suggested that cancer stem cells account for radiotherapy resistance. By flow cytometry, different expression percents of CD133 and OCT4 in thyroid cancer cell lines were detected. Read More

    Synchronous malignancies of thyroglossal duct cyst and thyroid gland.
    Natl Med J India 2017 Mar-Apr;30(2):76-77
    Radiation Medicine Centre (Bhabha Atomic Research Centre), Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra 400012; Homi Bhabha National Institute, Mumbai, Maharashtra, India.
    Malignant involvement of thyroglossal duct cyst is rare, still rarer is the synchronous malignant involvement of the thyroid gland. Although the Sistrunk procedure is often regarded as adequate, controversy exists of the need for an additional total thyroidectomy and radioiodine ablative therapy, the decision of which depends upon the presence of (i) suspicious thyroid gland nodule; (ii) presence of lymphadenopathy; or (iii) a previous history of neck irradiation. We report a 47-year-old woman diagnosed with papillary carcinoma within a recurrent thyroglossal duct cyst with infiltration into surrounding soft tissues and a suspicious thyroid nodule of the left thyroid lobe with no regional lymph node involvement. Read More

    Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis.
    Sci Rep 2017 Aug 15;7(1):8242. Epub 2017 Aug 15.
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 138-736, Republic of Korea.
    We compared the efficacy and complications of core-needle biopsy (CNB) with those of fine-needle aspiration (FNA) in a large population of patients with initially detected thyroid nodules via a propensity score analysis. Outpatients with initially detected thyroid nodules, who had undergone CNB or FNA between January 2013 and December 2013, were selected. This study included 4,822 thyroid nodules from 4,553 consecutive patients. Read More

    Temporal Changes in Thyroid Nodule Volume: Lack of Effect on Paranodular Thyroid Tissue Volume.
    Thyroid 2017 Sep 14. Epub 2017 Sep 14.
    1 Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma Sapienza , Rome, Italy .
    Background: The term "nodular goiter" has long been used to refer to a nodular thyroid gland, based on the assumption that nodule growth may be associated with hyperplasia of the surrounding non-nodular tissue. The aim of this prospective, multicenter, observational study was to determine whether nodule growth is accompanied by growth in the non-nodular tissue.

    Methods: Eight Italian thyroid-disease referral centers enrolled 992 consecutive patients with one to four benign nodules. Read More

    Glomus Tumor of the Neck Detected With 99mTc EDDA HYNIC-TOC.
    Clin Nucl Med 2017 Oct;42(10):758-760
    From the *Clinical Department of Nuclear Medicine, and †Clinical Department of Radiology, Clinical Hospital Centre Rijeka, Krešimirova 42, Rijeka, Croatia.
    A 54-year-old woman was referred to thyroid evaluation because of a lump on the left side of the neck. Ultrasound exam did not show any thyroid abnormality, but highly perfused nodule at the left common carotid artery bifurcation was found. Because of the specific location, somatostatin receptor scintigraphy with Tc EDDA HYNIC-TOC was performed, starting with perfusion images and followed with SPECT/CT imaging at 2 and 4 hours. Read More

    A Recurrent Episode of Dermatomyositis Associated with Papillary Thyroid Cancer.
    Case Rep Endocrinol 2017 19;2017:7985953. Epub 2017 Jul 19.
    Department of Endocrinology, Swedish American Hospital, 1253 N. Alpine Road, Rockford, IL 61107, USA.
    Objective: It is uncommon for dermatomyositis to be associated with papillary thyroid cancer. We report an unusual case of papillary thyroid cancer presenting with dermatomyositis.

    Methods: The case history, imaging and laboratory data is reviewed. Read More

    Patients with Non-invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features are Unlikely to have Malignant Preoperative Cytology.
    Ann Surg Oncol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.
    Background: The newly termed tumor 'noninvasive follicular thyroid neoplasm with papillary-like nuclear features' (NIFTP) acts in an indolent manner and can likely be safely managed with a thyroid lobectomy. Preoperative fine-needle aspiration (FNA) is the cornerstone of surgical planning, but the ability of FNA to distinguish NIFTP from other variants of papillary thyroid carcinoma (PTC) has not been well-evaluated.

    Methods: A 9-year retrospective review of the preoperative cytology and surgical pathology of PTC patients who underwent a thyroidectomy at our tertiary referral center. Read More

    Predicting thyroid nodule malignancy at several prevalence values with a combined Bethesda-molecular test.
    Transl Res 2017 Oct 22;188:58-66.e1. Epub 2017 Jul 22.
    Université Lyon 1, Lyon, France; Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; CNRS UMR5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, Villeurbanne, France.
    Investigation of thyroid nodules using fine-needle aspiration cytology (FNAC) gives indeterminate results in up to 30% of samples using the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). We present a combined Bethesda-molecular predictor of nodule malignancy to improve the accuracy of the preoperative diagnosis of thyroid nodules. To detect a molecular signature of thyroid nodule malignancy, a molecular test was performed on FNACs from 128 thyroid nodules from prospectively included patients, collected in a tertiary center. Read More

    Validation of the modified 4-tiered categorization system through comparison with the 5-tiered categorization system of the 2015 American Thyroid Association guidelines for classifying small thyroid nodules on ultrasound.
    Head Neck 2017 Aug 10. Epub 2017 Aug 10.
    Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, Seoul, Korea.
    Background: The purpose of this study was to validate the modified 4-tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines.

    Methods: From January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines. Read More

    (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography May Exclude Malignancy in Sonographically Suspicious and Scintigraphically Hypofunctional Thyroid Nodules and Reduce Unnecessary Thyroid Surgeries.
    Thyroid 2017 Sep 15. Epub 2017 Sep 15.
    1 Department of Nuclear Medicine, Medical Faculty, University Duisburg-Essen , Essen, Germany .
    Background: The aim of this study was to evaluate whether (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful in the further characterization of sonographically suspicious and scintigraphically hypofunctional thyroid nodules.

    Methods: Sixty-five patients with sonographically suspicious thyroid nodules that were hypofunctional on 99m-Tc-pertechnetate scintigraphy (diameter >1 cm) were retrospectively analyzed. All patients underwent evaluation with FDG-PET/CT. Read More

    The percentage of serum thyroglobulin rise in the first-week did not predict the eventual success of high-intensity focussed ablation (HIFU) for benign thyroid nodules.
    Int J Hyperthermia 2017 Aug 10:1-6. Epub 2017 Aug 10.
    c Department of Radiology , The University of Hong Kong , Hong Kong SAR , China.
    Background: Given that high-intensity focussed ultrasound (HIFU) of benign thyroid nodules often causes a massive release of thyroglobulin (Tg) into the circulation, we hypothesised a greater initial Tg rise may result in a greater nodule shrinkage 6 months after ablation.

    Methods: One hundred and five patients who underwent HIFU for symptomatic benign thyroid nodule from 2015 to 2016 were analysed. Serum Tg and anti-Tg autoantibody were checked on treatment day (baseline) and 4 d after treatment. Read More

    Factors Associated With Discordance Between Preoperative Parathyroid 4-Dimensional Computed Tomographic Scans and Intraoperative Findings During Parathyroidectomy.
    JAMA Surg 2017 Aug 9. Epub 2017 Aug 9.
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles.
    Importance: Parathyroid 4-dimensional computed tomographic scans (4D-CTs) have emerged as an accurate and cost-effective initial localization study for patients with primary hyperparathyroidism. However, potential limitations and factors affecting the accuracy of preoperative 4D-CTs remain poorly defined.

    Objectives: To characterize factors associated with missed parathyroid lesions on preoperative 4D-CTs and to investigate patterns of commonly observed errors. Read More

    Detection of Malignancy Among Suspicious Thyroid Nodules <1 cm on Ultrasound with Various Thyroid Image Reporting and Data Systems.
    Thyroid 2017 Sep 19. Epub 2017 Sep 19.
    2 Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine , Asan Medical Center, Seoul, Korea.
    Background: In patients undergoing active surveillance of papillary thyroid microcarcinoma, definitive therapy-usually preceded by a definitive diagnostic procedure-is not recommended until evidence of disease progression is obtained, as stated in the American Thyroid Association guidelines. This is because the deferring of definitive diagnosis and therapy until disease progression has no impact on the disease-specific survival. This study evaluated the malignancy rate and probability of thyroid nodules, which was further stratified based on the size cutoff value of 1 cm, with suspicious findings on ultrasonography (US), by using various malignant stratification systems. Read More

    Serum leptin levels and GHR-d3/fl gene polymorphism in acromegalic patients with thyroid nodules.
    Adv Clin Exp Med 2017 Mar-Apr;26(2):281-286
    Department of Endocrinology and Metabolism, Pamukkale University, Denizli, Turkey.
    Background: Acromegaly is a rare and serious syndrome that is commonly associated with pituitary neoplasms. Thyroid multinodular disease is a common finding in acromegaly. Leptin is a polypeptide hormone, and studies have shown that it can increase cell proliferation and inhibit apoptosis. Read More

    [Preliminary experience with transoral endoscopic thyroidectomy via vestibular approach: a report of 150 cases in a single center].
    Zhonghua Wai Ke Za Zhi 2017 Aug;55(8):587-591
    Department of Thyroid Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
    Objective: To summarize the preliminary experience with transoral endoscopic thyroidectomy via vestibular approach (TOETVA). Methods: A total of 150 consecutive patients with thyroid disease underwent TOETVA from November 2014 to February 2017 at Department of Thyroid Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine. The patients were comprised of 138 females and 12 males. Read More

    European Thyroid Association Guidelines regarding Thyroid Nodule Molecular Fine-Needle Aspiration Cytology Diagnostics.
    Eur Thyroid J 2017 Jul 19;6(3):115-129. Epub 2017 May 19.
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
    Molecular fine-needle aspiration (FNA) cytology diagnostics has the potential to address the inherent limitation of FNA cytology which is an indeterminate (atypia of undetermined significance/follicular lesion of undetermined significance follicular neoplasm) cytology. Because of the emerging role of molecular FNA cytology diagnostics, the European Thyroid Association convened a panel of international experts to review methodological aspects, indications, results, and limitations of molecular FNA cytology diagnostics. The panel reviewed the evidence for the diagnostic value of mutation panel assessment (including at least BRAF, NRAS, HRAS, KRAS, PAX8/PPARG, RET/PTC) of targeted next generation sequencing and of a microarray gene expression classifier (GEC) test in the diagnostic assessment of an indeterminate cytology thyroid nodule. Read More

    Pathological findings of Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident, 2013-2016.
    Anim Sci J 2017 Aug 4. Epub 2017 Aug 4.
    Laboratory of Veterinary Radiology and Radiation Biology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan.
    Fifty-one Japanese black cattle from four farms in the evacuation zone of the Fukushima nuclear accident were examined pathologically during the period, 2013-2016. We found no evidence of a radiation effect on pathological findings in any of these autopsy cases, although nine cases (3.7%) of enzootic bovine leukosis (EBL) and three cases (1. Read More

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