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    Intravascular Large B-Cell Lymphoma Within a Thyroid Nodule: A Diagnostic Pitfall.
    Int J Surg Pathol 2018 Mar 1:1066896918763282. Epub 2018 Mar 1.
    1 Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
    Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large B-cell lymphoma, where the neoplastic lymphoid proliferation resides predominantly within the lumens of blood vessels but with no or few circulating neoplastic cells in the peripheral circulation. Focal or subtle involvement in some cases can cause the diagnosis to be misinterpreted or even overlooked, delaying the initiation of appropriate treatment. Our report focuses on a 78-year-old woman with a progressively enlarging thyroid mass, verified by ultrasound. Read More

    Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study.
    Endocrine 2018 Mar 22. Epub 2018 Mar 22.
    Istituto Nazionale per lo studio e la Cura dei Tumori, Fondazione G. Pascale, IRCCS, Napoli, Italy.
    Purpose: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules.

    Methods: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4-5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Read More

    Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells.
    Mol Med Rep 2018 Mar 16. Epub 2018 Mar 16.
    Department of Clinical and Experimental Medicine, University of Pisa, I‑56126 Pisa, Italy.
    Recently it has been hypothesized that vanadium serves a carcinogenic role in the thyroid. However, to date, no in vivo or in vitro studies have evaluated thyroid disruption in humans and/or animals following exposure to vanadium. The present study evaluated the effect of vanadium pentoxide (V2O5) on cell viability and proliferation, and chemokine (C‑X‑C motif) ligand (CXCL)8 and CXCL11 secretion in normal thyrocytes. Read More

    Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study.
    World J Clin Cases 2018 Mar;6(3):20-26
    Department of Biostatistics, Inonu University Faculty of Medicine, Malatya 44280, Turkey.
    Aim: To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery.

    Methods: We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant (= 92) and benign (= 413) groups depending on the final pathological results. Read More

    Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study.
    Eur Radiol 2018 Mar 19. Epub 2018 Mar 19.
    Department of Radiology, The University of Hong Kong Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR, China.
    Objectives: Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation.

    Methods: One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15. Read More

    Expression of human telomerase reverse transcriptase (hTERT) in thyroid neoplasms.
    J BUON 2018 Jan-Feb;23(1):229-233
    Health Sciences University, Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey.
    Purpose: Distinction of thyroid neoplasms that include papillary carcinoma (PC) and follicular carcinoma (FC) from benign thyroid neoplasms can be performed successfully by histopathologic examination in most of the cases. However, in some cases it may be difficult to distinct PC and FC as well as FC and follicular adenoma (FA) and also FA and the dominant nodule of multinodular goiter (MNG) histopathologically. In this study, we aimed to determine the role of expression of the human telomerase reverse transcriptase (hTERT) in the distinction of thyroid neoplasms and its relation with prognostic factors by immunohistochemical methods. Read More

    Diagnostic Accuracy of Ultrasound with Color Flow Doppler in Children with Thyroid Nodules.
    J Clin Endocrinol Metab 2018 Mar 12. Epub 2018 Mar 12.
    Children's Hospital of Philadelphia, Division of Endocrinology and Diabetes.
    Context: Thyroid nodules are increasingly recognized in children and are associated with a greater risk for thyroid cancer compared to adults. Thyroid ultrasound is the favored tool for evaluation of thyroid nodules; however, there are limited data regarding the accuracy of thyroid ultrasound to confirm features associated with a low risk of thyroid cancer in children.

    Objectives: We examined whether thyroid ultrasound is capable of accurately identifying thyroid nodules at a low risk of malignancy in children. Read More

    Ensuring patient safety when implementing a new diagnostic pathway for thyroid nodules.
    Ann R Coll Surg Engl 2018 Mar 15:1-5. Epub 2018 Mar 15.
    Ear, Nose and Throat Department, William Harvey Hospital, East Kent Hospitals University Foundation Trust, Willesborough , Ashford , UK.
    Introduction The aim of this study was to determine whether ultrasound alone is sufficient to safely exclude malignancy in thyroid nodules in a district general hospital setting, to comply with the latest British Thyroid Association guidelines. Methods This retrospective study investigated the quality of ultrasound reporting and the correlation between ultrasound report and histology for individual thyroid nodules. Cases were selected from the thyroid multidisciplinary meeting and included all patients having undergone surgery for a thyroid malignancy in a one-year period. Read More

    Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology.
    Korean J Intern Med 2018 Mar 13. Epub 2018 Mar 13.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
    Background/aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients.

    Methods: We retrospectively reviewed the data of patient who had lymphocytic thyroitidis on FNA cytology of thyroid nodule from January 2005 to December 2010 at a tertiary referral hospital. Read More

    Thyroid Disease in Pregnancy: A Clinical Survey among Endocrinologists, Gynecologists, and Obstetricians in Israel.
    Isr Med Assoc J 2018 Mar;20(3):167-171
    Department of Endocrine Institute, Assaf Harofeh Medical Center, Zerifin, Israel.
    Objectives: To study the current practices in the management of subclinical hypothyroidism (SCH) and thyroid nodules during pregnancy of obstetricians/gynecologists (OB/GYNs) and endocrinologists in Israel.

    Methods: An electronic questionnaire was sent by email to all members of the Israeli Endocrine Society and the Israel Society of Obstetrics and Gynecology. Questionnaires included demographic data and clinical scenarios with questions regarding the screening and management of pregnant women with SCH, hypothyroxinemia, and a palpable thyroid nodule. Read More

    Comparison of incidental versus palpable thyroid nodules presenting for fine-needle aspiration biopsy.
    Head Neck 2018 Mar 9. Epub 2018 Mar 9.
    Department of Otolaryngology - Head and Neck Surgery, Henry Ford Health System, Detroit, Michigan.
    Background: Many attribute the rise in incidence of thyroid cancer to a deluge of radiologically identified incidental thyroid nodules. The clinical implications are unclear.

    Methods: A review was performed of all patients who underwent fine-needle aspirations of thyroid nodules by our academic medical center's Endocrinology Division between 2006 and 2010. Read More

    Reasons Associated with Total Thyroidectomy as Initial Surgical Management of an Indeterminate Thyroid Nodule.
    Ann Surg Oncol 2018 Mar 8. Epub 2018 Mar 8.
    Department of Surgery, The Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
    Background: Diagnostic hemithyroidectomy (HT) is the most widely recommended surgical procedure for a nodule with indeterminate cytology; however, additional details may make initial total thyroidectomy (TT) preferable. We sought to identify patient-specific factors (PSFs) associated with initial TT in patients with indeterminate thyroid nodules.

    Methods: Retrospective analysis of all patients with a thyroid nodule ≥ 1 cm and initial cytology of atypia of undetermined significance or suspicious for follicular neoplasm between 2012 and 2015 who underwent thyroidectomy. Read More

    Intrathyroidal thymic tissue in children: Avoiding unnecessary surgery.
    J Pediatr Surg 2018 Feb 8. Epub 2018 Feb 8.
    Division of Pediatric General and Thoracic Surgery, The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:
    Background/purpose: Intrathyroidal thymic tissue may be misinterpreted as a thyroid lesion in children, leading to invasive tests or resection. We sought to describe the characteristic imaging features of these lesions and to evaluate the safety of non-operative management.

    Methods: A retrospective review of all patients less than 18years old with intrathyroidal thymic tissue from 2000 to 2016 was performed. Read More

    The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma.
    Medicine (Baltimore) 2018 Mar;97(10):e9712
    Department of Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University.
    This study investigates the application of ultrasound, especially the anteroposterior diameter of nodules in the malignancy and metastasis risk assessment of papillary thyroid microcarcinoma through a retrospective analysis of 500 cases of thyroid nodule ultrasonography.We selected 500 patients with thyroid nodules (maximum nodule diameter ≤2.0 cm) that had been diagnosed clinically and graded TI-RADS 4c by ultrasonography and surgically treated. Read More

    Bone metastases without primary tumor: A well-differentiated follicular thyroid carcinoma case.
    J Cancer Res Ther 2018 Jan-Mar;14(2):447-450
    Department of Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
    Metastases to the bone are the most common malignant bone tumors. Prostate, breast, and lung carcinomas are the most common primaries of bone metastases. Bone metastases show poor prognosis in means of median survival; however, some patients with highly curable tumors such as thyroid carcinoma may benefit from treatment. Read More

    Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations.
    Diagn Cytopathol 2018 Mar 8. Epub 2018 Mar 8.
    Division of Endocrinology and Metabolism, NYU School of Medicine, NYU Langone Medical Center, New York, New York.
    Background: Thyroid-stimulating hormone receptor (TSHR) gene mutations play a critical role in thyroid cell proliferation and function. They are found in 20%-82% of hyperfunctioning nodules, hyperfunctioning follicular thyroid cancers (FTC), and papillary thyroid cancers (PTC). The diagnostic importance of TSHR mutation testing in fine needle aspiration (FNA) specimens remains unstudied. Read More

    A predictive model of thyroid malignancy using clinical, biochemical and sonographic parameters for patients in a multi-center setting.
    BMC Endocr Disord 2018 Mar 7;18(1):17. Epub 2018 Mar 7.
    Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.
    Background: Thyroid nodules are highly prevalent, but a robust, feasible method for malignancy differentiation has not yet been well documented. This study aimed to establish a practical model for thyroid nodule discrimination.

    Methods: Records for 2984 patients who underwent thyroidectomy were analyzed. Read More

    Tumor growth rate of follicular thyroid carcinoma is not different from that of follicular adenoma.
    Clin Endocrinol (Oxf) 2018 Mar 6. Epub 2018 Mar 6.
    Departments of Internal Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
    Objective: Distinguishing malignancy from benign thyroid nodule has always been challenging, especially in follicular lesions. Thyroid nodules with small size and indeterminate cytology do not lead to immediate surgery. We tried to evaluate whether tumor size and tumor growth rate can distinguish follicular thyroid carcinoma (FTC) from follicular adenoma (FA). Read More

    The Diagnosis and Management of Thyroid Nodules: A Review.
    JAMA 2018 Mar;319(9):914-924
    Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Importance: Thyroid nodules are common, being detected in up to 65% of the general population. This is likely due to the increased use of diagnostic imaging for purposes unrelated to the thyroid. Most thyroid nodules are benign, clinically insignificant, and safely managed with a surveillance program. Read More

    Diagnostic value of computed tomography (CT) histogram analysis in thyroid benign solitary coarse calcification nodules.
    J Zhejiang Univ Sci B 2018 Mar.;19(3):211-217
    Department of Radiology, Hangzhou First People's Hospital, Hangzhou 310006, China.
    This study was to investigate the diagnostic value of the computed tomography (CT) histogram in thyroid benign solitary coarse calcification nodules (BSCNs). A total of 89 thyroid solitary coarse calcification nodules (coarse calcification ≥5 mm, no definite soft tissue around calcification) confirmed either by surgery or histopathological examination in 86 cases enrolled from January 2009 to December 2015 were evaluated. These included 56 BSCNs and 33 malignant solitary coarse calcification nodules (MSCNs). Read More

    Improved Quality of Thyroid Ultrasound Reports After Implementation of the ACR Thyroid Imaging Reporting and Data System Nodule Lexicon and Risk Stratification System.
    J Am Coll Radiol 2018 Mar 1. Epub 2018 Mar 1.
    Department of Radiology, Duke University Medical Center, Durham, North Carolina. Electronic address:
    Purpose: The aim of this study was to compare the description and management recommendations for thyroid nodules before and after implementing a structured reporting template based on the ACR Thyroid Imaging Reporting and Data System (TI-RADS).

    Methods: Thyroid ultrasound reports for seven private practice radiologists were analyzed in three phases. In phase 1, radiologists dictated in a free-text format. Read More

    [Screening of benign and malignant thyroid nodules in 5 196 physical examination population].
    Zhonghua Zhong Liu Za Zhi 2018 Feb;40(2):151-154
    Cancer Prevent Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
    To investigate the distribution characteristics of thyroid nodules and thyroid cancer in physical examination population in Tianjin, and report the outcome of ultrasonography in detection of thyroid nodules.Enrolled all of physical examination population in our hospital from Jan 1, 2014 to Dec 31, 2014 as our study subjects then the thyroid gland lesions were screened by ultrasound diagnostic technique. The risk assessment of benign and malignant thyroid nodules was assessed by ultrasonography and thyroid imaging reporting and data system (TI-RADS), and the individuals were followed up for 1 year. Read More

    Reduction in Thyroid Nodule Biopsies and Improved Accuracy with American College of Radiology Thyroid Imaging Reporting and Data System.
    Radiology 2018 Apr 2;287(1):185-193. Epub 2018 Mar 2.
    From the Department of Radiology, Duke University Medical Center, Box 3808, Erwin Rd, Durham, NC 27710 (J.K.H., B.S.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (W.D.M., S.A.T.); Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC (A.E.F.); Department of Radiology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (J.E.L.); Department of Radiology, Mayo Clinic College of Medicine, Rochester Minn (C.C.R.); Mecklenburg Radiology Associates, Charlotte, NC (N.A., D.S.); Rocky Mountain Radiologists, Denver, Colo (F.J.B.); Radiology Partners Research Institute, El Segundo, Calif (A.J.B.); Department of Radiology, Division of Ultrasound, Mayo Clinic, Phoenix, Ariz (N.D.); Memphis Radiological Professional Corporation, Methodist Le Bonheur Healthcare Memphis, Germantown, Tenn (J.R.H.); Duke Radiology of Raleigh, Duke University School of Medicine, Duke Raleigh Hospital, Raleigh, NC (R.C.V.); and Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (F.N.T.).
    Purpose To compare the biopsy rate and diagnostic accuracy before and after applying the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) criteria for thyroid nodule evaluation. Materials and Methods In this retrospective study, eight radiologists with 3-32 years experience in thyroid ultrasonography (US) reviewed US features of 100 thyroid nodules that were cytologically proven, pathologically proven, or both in December 2016. The radiologists evaluated nodule features in five US categories and provided biopsy recommendations based on their own practice patterns without knowledge of ACR TI-RADS criteria. Read More

    Monopolar radiofrequency ablation of thyroid nodules: a prospective Austrian single center study.
    Thyroid 2018 Feb 28. Epub 2018 Feb 28.
    Department of Internal Medicine, Division of Endocrinology and Diabetology, Graz, Austria ;
    Background Monopolar radiofrequency ablation is currently deemed an exotic treatment option for benign thyroid nodules in many central European countries. The aim of this study was to prospectively evaluate safety and efficacy of this method in a large patient cohort following its introduction in Austria. Patients and methods Peri- and post-interventional complications were analyzed for 277 patients. Read More

    Ultrasonographic features and clinicopathologic characteristics of macrofollicular variant papillary thyroid carcinoma.
    Medicine (Baltimore) 2018 Mar;97(9):e8105
    Department of Surgery.
    Macrofollicular variant papillary thyroid carcinoma (MFV-PTC) is defined as papillary thyroid carcinoma with macrofollicles of >200 μm in more than 50% of the cross-sectional area of the specimen. The aim of this study was to evaluate the clinicopathologic characteristics of the MFV-PTC treated in the Yonsei University College of Medicine.Between September 2007 and July 2012, 18,697 patients with PTC were treated in our institution. Read More

    Local Anesthetic Systemic Toxicity Complicating Thyroid Biopsy.
    Cureus 2017 Dec 16;9(12):e1955. Epub 2017 Dec 16.
    Department of Medicine, Oregon Health and Science University, Portland, Oregon.
    The overdiagnosis of thyroid malignancies may be contributing to the increased incidence of these cancers with a relatively stable mortality rate. We present the case of a man with known malignancies, who underwent biopsy of a suspicious thyroid nodule. This procedure was complicated by local anesthetic systemic toxicity (LAST). Read More

    Evaluation of the Stiffness of Tissues Surrounding Thyroid Nodules with Shear Wave Elastography.
    J Ultrasound Med 2018 Feb 26. Epub 2018 Feb 26.
    Department of Ultrasound, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
    Objectives: This study evaluated the stiffness of tissue surrounding thyroid nodules using shear wave elastography (SWE).

    Methods: A total of 128 thyroid nodules in 108 patients were examined with conventional ultrasound imaging and SWE. The maximum Young modulus value was measured to evaluate the stiffness of the thyroid nodules (E) and the 2-mm perinodular region (E). Read More

    Sclerosing mucoepidermoid carcinoma with eosinophilia: Cytologic characterization of a rare distinct entity in the thyroid.
    Diagn Cytopathol 2018 Feb 26. Epub 2018 Feb 26.
    Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
    Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an extremely rare thyroid carcinoma with limited cytologic descriptions in the literature. Here, we present a 52-year-old woman with a 3.9 cm thyroid nodule. Read More

    Acorrelation study between histological results and thyroid ultrasound findings. The TI-RADS classification.
    Endocrinol Diabetes Nutr 2018 Feb 20. Epub 2018 Feb 20.
    Servicio de Radiodiagnóstico, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.
    Introduction: There are several classifications based on thyroid ultrasound for selecting suspected malignant thyroid nodules. The Thyroid Imaging Reporting and Data System (TI-RADS) classification proposed by Horvath in 2009 includes 6 categories.

    Objetives: To assess the sensitivity of the TI-RADS classification for diagnosing thyroid nodules. Read More

    Revised Value of Contrast-Enhanced Ultrasound for Solid Hypo-Echoic Thyroid Nodules Graded with the Thyroid Imaging Reporting and Data System.
    Ultrasound Med Biol 2018 Feb 19. Epub 2018 Feb 19.
    Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
    The use of ultrasound in differentiation of benign and malignant solid hypo-echoic thyroid nodules is a dilemma in clinical practice. The aim of this study was to investigate the revised value of contrast-enhanced ultrasound (CEUS) for differentiating solid hypo-echoic thyroid nodules using the Thyroid Imaging Reporting and Data System (TI-RADS).The study included 135 patients with 135 nodules confirmed by fine-needle aspiration and/or surgery. Read More

    Incidental Diagnosis of Parathyroid Lesions by Preoperative Use of Next-Generation Molecular Testing.
    World J Surg 2018 Feb 22. Epub 2018 Feb 22.
    Division of Endocrine Surgery, University of Pittsburgh, 3471 Fifth Ave, Kauffman Bldg, Ste 101, Pittsburgh, PA, 15213, USA.
    Background: Parathyroid glands can mimic thyroid follicular lesions on fine-needle aspiration (FNA) cytology and can lead to unnecessary or incorrect surgery. Newer molecular panel tests using next-generation sequencing (NGS) include analysis of cell type-specific gene expression profiles such as parathyroid. The study aim is to determine the frequency and clinical implications of parathyroid tissue identification by molecular testing in cytologically indeterminate "thyroid" lesions. Read More

    Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity.
    Korean J Intern Med 2018 Feb 23. Epub 2018 Feb 23.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital Seoul, Seoul, Korea.
    Background/aims: The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules.

    Methods: One hundred and nineteen patients with thyroid nodules undergoing SWE before ultrasound-guided fine needle aspiration and core needle biopsy were analyzed. The mean (EMean), minimum (EMin), maximum (EMax), and standard deviation (ESD) of SWE elasticity indices were measured. Read More

    Use of the ultrasound-based total malignancy score in the management of thyroid nodules.
    Ultrasonography 2018 Jan 6. Epub 2018 Jan 6.
    Radiology Unit 1, ASST Santi Paolo e Carlo, Milan, Italy.
    Purpose: The purpose of this study was to validate the role of the total malignancy score (TMS) in identifying thyroid nodules suspicious for malignancy through the sum of their ultrasound features.

    Methods: The local ethical committee approved this prospective observational study. We examined 231 nodules in 231 consecutive patients (164 females and 67 males; age range, 20 to 87 years; median age, 59 years; interquartile range, 48 to 70 years) who underwent ultrasound followed by fine-needle aspiration cytology (FNAC). Read More

    Erratum to "Inter-exam agreement and diagnostic performance of the Korean Thyroid Imaging Reporting and Data System for thyroid nodule assessment: Real-time versus static ultrasonography" [Eur. J. Radiol. 98 (2018) 14-19].
    Eur J Radiol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

    Does sedation offer better outcomes than local anaesthesia for thyroid FNA in adult patients?
    Cytopathology 2018 Feb 18. Epub 2018 Feb 18.
    Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.
    Objective: To examine the potential benefits of sedation in adults undergoing fine needle aspiration (FNA) of thyroid nodules.

    Methods: This retrospective study compared the outcomes of sedated and non-sedated FNA patients.

    Results: A total of 860 patients underwent 1698 FNAs of thyroid nodules. Read More

    Endoscopic Thyroid Surgery Through Trans-oral Vestibular Approach (TOVA): A Case Series and Review of Literature.
    Indian J Otolaryngol Head Neck Surg 2018 Mar 10;70(1):162-166. Epub 2017 Aug 10.
    Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014 U.P. India.
    Endoscopic surgery is now standard of care for different Endocrine Disorders; the endoscopic thyroid surgery is becoming more popular and different approaches has been practice by many thyroid surgeon worldwide. Trans-orovestibular approach, based on the principle of natural orifice transluminal surgery is truly scar free thyroid surgery and has minimal dissection. We are presenting here three cases of benign solitary thyroid nodule operated endoscopically through trans-oro-vestibular approach in one male and two female patients. Read More

    High-intensity focused ultrasound (HIFU) therapy for benign thyroid nodules without anesthesia or sedation.
    Endocrine 2018 Feb 16. Epub 2018 Feb 16.
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, 6500, Switzerland.
    Background: Thermal ablation of thyroid nodules has gained momentum due to the possibility to avoid surgery. High-intensity focused ultrasound (HIFU) allows thermal treatment by energy ultrasound beam inside the targeted zone. Aim of our study was to evaluate the effects of HIFU treatment using Beamotion mode without anesthesia. Read More

    Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children.
    Endocr Relat Cancer 2018 Apr 16;25(4):481-491. Epub 2018 Feb 16.
    Division of EndocrinologyDiabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
    With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation-exposed children. 764 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. Read More

    Diagnostic Performance of Margin Features in Thyroid Nodules in Prediction of Malignancy.
    AJR Am J Roentgenol 2018 Apr 15;210(4):860-865. Epub 2018 Feb 15.
    3 Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr, H1307, Stanford, CA 94305.
    Objective: The purpose of this study was to evaluate thyroid nodule margins for specific morphologic features and determine the diagnostic performance of these features in differentiating papillary carcinoma from benign thyroid nodules.

    Materials And Methods: Nodules measuring 1-3 cm in largest diameter that had been evaluated with high-resolution ultrasound (12-18 MHz) and ultrasound-guided biopsy with definitive pathologic diagnosis were analyzed. Three blinded board-certified readers evaluated high-resolution images of each nodule for jagged edges, lobulated borders, and curved borders along their margins. Read More

    Trauma-induced Focal Nodular Mucinoses: A Rare Entity.
    Indian Dermatol Online J 2018 Jan-Feb;9(1):50-52
    Department of Pathology, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Cutaneous mucinoses refer to disorders with abnormal accumulation of mucin in the skin. Mucin is an amorphous material that is a part of the extracellular matrix in dermis. Cutaneous mucinoses could be primary or secondary. Read More

    Mantle Cell Lymphoma in the Thyroid: A Rare Presentation.
    Case Rep Pathol 2017 25;2017:6749801. Epub 2017 Dec 25.
    Division of Endocrinology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA.
    Background: While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.

    Patient Findings: A 65-year-old female was referred for a multinodular goiter. Read More

    The Sonographic Subcentimeter Malignant Thyroid Nodule: What Does It Stand for?
    Am Surg 2018 Jan;84(1):137-139
    Thyroid cancer management has moved to less extensive surgery in lesions with favorable criteria. Our study evaluated if the sonographic (US) size of thyroid nodules is a reliable criterion to determine the extent of surgery in patients with papillary thyroid carcinoma (PTC). A retrospective study was performed to evaluate thyroid nodules measuring <10 mm in the preop sonogram with a permanent pathology of PTC. Read More

    Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study.
    J Cancer Res Clin Oncol 2018 Apr 9;144(4):771-779. Epub 2018 Feb 9.
    Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, China.
    Purpose: To evaluate the safety and efficacy of ultrasound-guided low-power microwave ablation (MWA) for the treatment of papillary thyroid microcarcinoma (PTMC) with a 3-year follow-up.

    Methods: A total of 21 nodules diagnosed as PTMC from the 15 patients were performed with MWA at a power of 20 W. The images of the nodules were recorded by ultrasound before MWA and 1, 3, 6, 12 months after MWA, and every 6 months thereafter, respectively. Read More

    Incidental thyroid carcinoma in patients with TIR1, TIR2 and TIR3 FNA.
    Ann Ital Chir 2018 Feb 9;7. Epub 2018 Feb 9.
    Aim: The aim of our study was to evaluate the presence of incidental differentiated thyroid carcinomas, at final histological examination, in patients undergoing thyroidectomy or lobectomy for presumed benign pathology or in those with cytological diagnosis of indeterminate nodules (TIR3).

    Material Of Study: 457 patients who underwent surgery for benign disease and 179 patients with indeterminate FNA were included in our study.

    Results: 77 out of 457 patients had the diagnosis of differentiated thyroid carcinoma. Read More

    Clinicopathological significance of chemokine receptor CXCR4 expression in papillary thyroid carcinoma: a meta-analysis.
    Minerva Endocrinol 2018 Feb 8. Epub 2018 Feb 8.
    Department of General Surgery, Nanjing Hospital of Traditional Chinese Medicine, No.3 Affiliated Hospital of Nanjing, University of Chinese Medicine, Nanjing, Jiangsu, P.R China -
    Introduction: Emerging evidence indicates that C-X-C chemokine receptor type 4(CXCR 4) is a candidate oncogene in several types of human tumors including papillary thyroid carcinoma (PTC). To investigate its expression impact on clinicopathological features, a meta-analysis was performed.

    Evidence Acquisition: A comprehensive search in the PubMed, Embase and The Cochrane Library (up to March 14, 2017) was performed for relevant studies using multiple search strategies. Read More

    Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis.
    Arch Endocrinol Metab 2017 Dec;61(6):643-646
    Department of Biomedical Sciences and Morphological and Functional Images, Unit of Nuclear Medicine, University of Messina, Messina, Italy.
    Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Read More

    It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature.
    BMC Cancer 2018 02 6;18(1):146. Epub 2018 Feb 6.
    Department of Clinical Medicine and Surgery, University of Naples "Federico II", via Sergio Pansini, 80131, Naples, Italy.
    Background: Metastases to the thyroid gland are more frequent than previously thought, although most of them are occult or not clinically relevant. Overall, only 42 cases of metastases to thyroid from breast cancer have been reported thus far. Here we report the case of a patient with breast cancer metastatic to the thyroid. Read More

    A single session of laser ablation for toxic thyroid nodules: three-year follow-up results.
    Int J Hyperthermia 2018 Feb 22:1-5. Epub 2018 Feb 22.
    b Studio Tiroide Prof. De Feo , Perugia , Italy.
    Purpose: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up.

    Material And Methods: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goitre. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated. Read More

    Predictive Value of Malignancy of Thyroid Nodule Ultrasound Classification Systems. A Prospective Study.
    J Clin Endocrinol Metab 2018 Feb 1. Epub 2018 Feb 1.
    Department of Endocrinology & Metabolism, Ospedale Regina Apostolorum, Albano (Rome).
    Background: British Thyroid Association (BTA), American Thyroid Association (ATA) and American Association of Clinical Endocrinologists (AACE/ACE/AME) recommend for thyroid nodules an ultrasound (US)-based stratification of risk of malignancy. Aim of our study was to assess the diagnostic accuracy of US classification systems and their reliability for indication to fine-needle aspiration (FNA).

    Methods: Prospective study on 987 thyroid nodules consecutively referred for FNA. Read More

    Galectin-3 and HBME-1 Expression on Agarose Cell Blocks from Fine-needle aspirates of Follicular Cell-derived Thyroid Tumors.
    J Cytol 2018 Jan-Mar;35(1):27-32
    Department of Pathology, Faculty of Medicine, Cairo University, Egypt.
    Aim: To test the expression of galectin-3 (gal-3) and Hector Battifora mesothelial antigen-1 (HBME-1) on agarose cell blocks (CBs) of fine-needle aspirates aiming to determine their diagnostic value in thyroid follicle cell-derived tumors.

    Materials And Methods: Forty patients with thyroid nodule were enrolled. Fine-needle aspiration biopsy was done and processed to produce smears and CBs. Read More

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