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    Relationship between metabolic syndrome and nodular thyroid diseases.
    Scand J Clin Lab Invest 2017 Nov 16:1-5. Epub 2017 Nov 16.
    a Faculty of Medicine, Internal Medicine Department , Duzce University , Duzce , Turkey.
    Nodular thyroid diseases are common in Turkey. Insulin resistance (IR) is considered as the most important component of metabolic syndrome (MetS), and it is thought to directly affect thyroid diseases, together with other components of MetS. The aim of this study was to evaluate potential factors associated with thyroid nodularity. Read More

    MiR-324-5p assists ultrasonography in predicting lymph node metastasis of unifocal papillary thyroid microcarcinoma without extracapsular spread.
    Oncotarget 2017 Oct 31;8(48):83802-83816. Epub 2017 Jul 31.
    Department of Ultrasonography, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Ultrasonography is the first choice of lymph node metastasis (LNM) detection which is crucial for therapeutic options of papillary thyroid cancer (PTC). However, the sensitivity of ultrasonography in detecting LNM of PTC is relatively low; especially in central LNM. MiR-324-5p has been reported to play important roles in the metastasis of various cancers. Read More

    Percutaneous laser ablation for benign thyroid nodules: a meta-analysis.
    Oncotarget 2017 Oct 17;8(47):83225-83236. Epub 2017 May 17.
    Department of Interventional Radiology, The Affiliated Renmin Hospital of Jiangsu University, Zhenjiang, 212002, China.
    Purpose: To evaluate percutaneous laser ablation in treating benign thyroid nodules, we conducted a meta-analysis based on summarizing existing researches.

    Materials And Methods: A literature search for clinical trial was performed in PubMed, Cochrane Library and Excerpt Medica Database. The qualities of included studies were evaluated. Read More

    A case report of recurrent thyroid inflammatory myofibroblastic tumor and its metastasis in soft tissue.
    Medicine (Baltimore) 2017 Nov;96(45):e8485
    aDepartment of Interventional Radiology, China Meitan General Hospital bDepartment of Pathology, Beijing Chaoyang Hospital of Capital Medical University, Beijing, China.
    Rationale: Inflammatory myofibroblastic tumor (IMT) is a neoplasm of low malignant potential. The most frequent site of IMT is in the lung, whereas recurrent and metastasis of thyroid IMT has been seldom reported.

    Patient Concerns: A 57-year-old male presented with a 3-year history of painless thyroid mass. Read More

    Papillary Thyroid Cancer and Coexisting Autoimmune Thyroiditis.
    Horm Metab Res 2017 Nov 14;49(11):869-872. Epub 2017 Nov 14.
    Endocrine and Nuclear Medicine Center Tegernsee, Tegernsee, Germany.
    Histological findings often display an association between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT) and so differ significantly from follicular thyroid carcinomas (FTC). The aim of this interdisciplinary, retrospective study was to evaluate the association of AIT in patients with PTC and FTC and a control group of benign nodular goiters. One hundred thyroidectomies with histologically confirmed differentiated thyroid carcinomas, 67 with PTC and 33 with FTC, were submitted for examination. Read More

    Cost-effectiveness of lobectomy versus genetic testing (Afirma®) for indeterminate thyroid nodules: Considering the costs of surveillance.
    Surgery 2017 Nov 8. Epub 2017 Nov 8.
    Department of Surgery, University of Wisconsin, Madison, WI.
    Background: We evaluated whether diagnostic thyroidectomy for indeterminate thyroid nodules would be more cost-effective than genetic testing after including the costs of long-term surveillance.

    Methods: We used a Markov decision model to estimate the cost-effectiveness of thyroid lobectomy versus genetic testing (Afirma®) for evaluation of indeterminate (Bethesda 3-4) thyroid nodules. The base case was a 40-year-old woman with a 1-cm indeterminate nodule. Read More

    Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature.
    J Pediatr Endocrinol Metab 2017 Nov 11. Epub 2017 Nov 11.
    .
    Background: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. Read More

    New terminology-noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) and its effect on the rate of malignancy at a single institution.
    Surgery 2017 Nov 7. Epub 2017 Nov 7.
    Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN.
    Background: The cytologic qualities of noninvasive follicular neoplasm with papillary-like nuclear features mimic papillary thyroid carcinoma (PTC) on fine-needle aspiration, leading to difficulty in distinguishing the 2 preoperatively. The aim of this study was to determine the impact of reclassification of noninvasive follicular neoplasm with papillary-like nuclear features at our practice.

    Methods: We searched 1,046 patient charts for those cases with preoperative cytology and subsequent follicular-variant papillary thyroid carcinoma diagnosis on resection. Read More

    Metastatic medullary thyroid carcinoma or calcitonin-secreting carcinoid tumor of lung? A diagnostic dilemma in a patient with lung mass and thyroid nodule.
    Diagn Cytopathol 2017 Nov 10. Epub 2017 Nov 10.
    Professor of Pathology, University of Minnesota, Minneapolis 55455.
    Calcitonin-secreting neuroendocrine tumors are rare and have been reported in literature as case reports or case series in various organs including lung, pancreas, larynx, bladder, and ovary. These tumors have similar cytologic features and immunohistochemical profile to medullary thyroid carcinoma and thus it is difficult to distinguish them, especially when calcitonin-secreting neuroendocrine tumors are intermediate or higher grade and there is a mass lesion in the thyroid gland. Here, we report a rare case of calcitonin secreting atypical carcinoid tumor of the lung in a patient with thyroid nodule. Read More

    A case of napsin A-positive metastatic lung cancer originating from the colon.
    Surg Case Rep 2017 Nov 9;3(1):114. Epub 2017 Nov 9.
    Department of General Thoracic Surgery, National Hospital Organization, Saitama National Hospital, 2-1 Suwa, Wako, Saitama, 351-0102, Japan.
    Background: We report a case of napsin A-positive metastatic lung cancer originating from the colon. No cases of napsin A-positive metastatic lung tumors originating from colorectal cancer have been reported previously.

    Case Presentation: Computed tomography identified a small lung nodule in a 70-year-old male patient, 18 months after resection for rectal cancer. Read More

    Size and Ultrasound Features Affecting Results of Ultrasound-Guided Fine-Needle Aspiration of Thyroid Nodules.
    J Ultrasound Med 2017 Nov 9. Epub 2017 Nov 9.
    Departments of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    Objectives: Our goal was to assess the diagnostic efficacy of ultrasound (US)-guided fine-needle aspiration (FNA) of thyroid nodules according to size and US features.

    Methods: A retrospective correlation was made with 1745 whole thyroidectomy and hemithyroidectomy specimens with preoperative US-guided FNA results. All cases were divided into 5 groups according to nodule size (≤5, 5. Read More

    Patients with papillary thyroid carcinoma associated with high stimulated serum calcitonin levels.
    Endocrinol Diabetes Metab Case Rep 2017 3;2017. Epub 2017 Nov 3.
    Departments of Endocrinology.
    Among various substances produced by C-cells, the most important one is calcitonin (CT) that is used for detection, post-operative follow-up and evaluation of individuals at risk of developing medullary thyroid carcinoma (MTC). However, the role of serum CT measurement in the evaluation of thyroid nodules has been widely discussed, and there is still no consensus about the role of CT in the initial evaluation of all thyroid nodules. Two patients with thyroid nodules whose fine-needle aspiration results were compatible with benign cytology besides having mildly elevated basal serum calcitonin levels were reported. Read More

    Cytomorphologic Diversity of Papillary Thyroid Carcinoma.
    J Cytol 2017 Oct-Dec;34(4):183-187
    Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    Introduction: Cytologic features of papillary thyroid carcinoma (PTC) have been extensively documented in literature. However, PTC variants can prove to be diagnostically challenging on fine needle aspiration cytology (FNAC).

    Aims: To study the FNAC features of PTC and its variants and explore the causes for misdiagnosis. Read More

    Study on the status of thyroid function and thyroid nodules in chinese breast cancer patients.
    Oncotarget 2017 Oct 24;8(46):80820-80825. Epub 2017 Aug 24.
    Department of Endocrine and Breast Surgery of The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
    We performed a study to investigate the status of thyroid nodules and thyroid functions in Chinese breast cancer women. The clinical data of female patients with breast cancer or benign breast diseases and normal populace were evaluated. The thyroxine(T4) level in initially diagnosed breast cancer patients were significantly higher than those in benign breast diseases patients (7. Read More

    Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study.
    Ultrasonography 2017 Sep 15. Epub 2017 Sep 15.
    Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, Korea.
    Purpose: The purpose of this study was to evaluate the diagnostic efficacy of fine-needle aspiration (FNA), core needle biopsy (CNB), and combined FNA/CNB for the first-line diagnosis of thyroid nodules.

    Methods: A total of 782 consecutive nodules that underwent simultaneous FNA and CNB were analyzed in this study. We compared the rate of inconclusive results and the diagnostic values for malignancy among FNA, CNB, and combined FNA/CNB. Read More

    Sonographic Features of Cervical Lymph Nodes in Patients With Hashimoto Thyroiditis and the Impacts From the Levothyroxine With Prednisone Therapy.
    Ultrasound Q 2017 Nov 6. Epub 2017 Nov 6.
    *Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University; and †Department of Clinical Medicine, Quanzhou Medical College, Quanzhou, Fujian, China.
    Objective: This study aimed to evaluate the ultrasonographic pattern of cervical lymph nodes (CLNs) and whether levothyroxine with prednisone therapy is effective for lymphadenopathy in patients with Hashimoto thyroiditis (HT).

    Methods: This retrospective study was looking at patients with confirmed diagnosis of HT who underwent comprehensive neck ultrasound examination. We reviewed sonographic findings in 127 patients with HT, 234 euthyroid patients with goiter, and 122 healthy subjects. Read More

    Validation of Three Scoring Risk Stratification Models for Thyroid Nodules.
    Thyroid 2017 Nov 6. Epub 2017 Nov 6.
    Chung Ang University Hospital, 65542, Department of Radiology, Seoul, Seoul, Korea (the Republic of) ;
    Background: To minimize potential harm from overuse of fine-needle aspiration, Thyroid Imaging Reporting and Data Systems (TIRADSs) were developed for thyroid nodule risk stratification. The purpose of this study was to perform validation of three scoring risk stratification models for thyroid nodules using ultrasonography features, a web-based malignancy risk stratification system at website (http://www.gap. Read More

    Novel insights in ultrasound evaluation of thyroid gland in children with papillary thyroid carcinoma.
    • Authors:
    Neuro Endocrinol Lett 2017 Oct 6;38(5):367-374. Epub 2017 Oct 6.
    Background: The coincidence of autoimmune thyroiditis (AIT) in patients with papillary thyroid carcinoma (PTC) is ranging between 10 and 58% in the general population.

    Material And Methods: In the present study retrospective ultrasound, clinical and autoimmune assessment of 24 patients diagnosed with papillary thyroid carcinoma between 2000-2016 was performed.

    Results: The coexistence of PTC and AIT was found in 50% of patients with PTC. Read More

    BRAF ANTIBODY EXPRESSION IN DIFFERENT TYPES OF THYROID NODULAR LESIONS.
    Georgian Med News 2017 Oct(271):107-113
    Davit Tvildiani Medical University, Tbilisi, Georgia.
    Major problems haunt the physicians who need to delineate the best management strategy for their patients with thyroid nodule is the identification of the most aggressive cases, especially among papillary thyroid cancers, which would benefit from more aggressive therapy and follow up. Beyond its strong correlation with PTC, the BRAF mutation is well described to associate with poor prognosis. The aim of our study was to identify BRAF antibody expression in different hystotypes of the thyroid nodules and assessment of it expression according to the tumor aggressiveness. Read More

    Evaluation of the thyroid nodule with high-resolution ultrasonography and elastography without fine needle aspiration biopsy.
    Med Clin (Barc) 2017 Oct 30. Epub 2017 Oct 30.
    Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, Servicio Murciano de Salud, El Palmar, Murcia, España; Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, España.
    Introduction: Fine needle aspiration biopsy (FNAB) is the gold standard screening technique used in the diagnostic protocol for thyroid nodules. However, it is not free of complications.

    Objective: To identify thyroid nodules in which FNAB could be avoided during the diagnostic process by means of the use of a high-resolution ultrasonography or elastography. Read More

    Thyroid Nodules With Nondiagnostic Cytologic Results: Follow-Up Management Using Ultrasound Patterns Based on the 2015 American Thyroid Association Guidelines.
    AJR Am J Roentgenol 2017 Nov 1:1-6. Epub 2017 Nov 1.
    1 Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
    Objective: The purpose of this study was to evaluate the malignancy rate of nodules with nondiagnostic cytologic results based on the American Thyroid Association (ATA) ultrasound (US) patterns and to suggest management guidelines for these nodules.

    Materials And Methods: From January 2013 to December 2014, 441 nodules (≥ 1 cm) were found in 437 patients with nondiagnostic results of ultrasound (US)-guided fine-needle aspiration biopsy (nondiagnostic nodules). A total of 191 nodules that were cytopathologically confirmed or were smaller (> 3 mm) at follow-up US were enrolled. Read More

    Papillary thyroid carcinoma in a boy with familial tuberous sclerosis complex attributable to a TSC2 deletion-a case report.
    Curr Oncol 2017 Oct 25;24(5):e423-e428. Epub 2017 Oct 25.
    Department of Pediatric Endocrinology and Rheumatology, 2nd Chair of Pediatrics, Karol Jonscher's Clinical Hospital, and.
    Tuberous sclerosis complex (tsc), a phacomatosis, is a rare genetic disease (autosomal dominant; incidence: 1 in 6,800-17,300) associated with mutations in the TSC1 and TSC2 genes, 70% of which are sporadic. The disease causes benign tumours in the brain, kidneys, heart, lungs, skin, and eyes; thyroid lesions are extremely rare. A 13-year-old euthyroid boy with a hereditary form of tsc (del 4730G in TSC2, also seen in 2 sisters and the father) was admitted to hospital with a thyroid nodule. Read More

    Computer-aided assessment of regional vascularity of thyroid nodules for prediction of malignancy.
    Sci Rep 2017 Oct 30;7(1):14350. Epub 2017 Oct 30.
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR, China.
    Color Doppler vascular index (VI) was assessed alone and in combination with grey-scale ultrasound (GSU) in regionally subdivided thyroid nodules in diagnosing thyroid cancer. Color Doppler sonograms of 111 thyroid nodules were evaluated by a home-developed algorithm that performed "offsetting" (algorithm for changing the area of a region of interest, ROI, without distorting the ROI's contour) and assessed peripheral, central and overall VI of thyroid nodules. Results showed that the optimum offset for dividing peripheral and central regions of nodule was 22%. Read More

    Associations of adiposity measurements with thyroid nodules in Chinese children living in iodine-sufficient areas: an observational study.
    BMJ Open 2017 Oct 30;7(10):e016706. Epub 2017 Oct 30.
    Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
    Objectives: Obesity has been found to be associated with an elevated risk of thyroid nodule(s), mainly in adults; however, evidence for this association in children was limited. The objective of this study was to investigate the association of adiposity and thyroid nodule(s) in children living in iodine-sufficiency areas.

    Setting And Participants: We conducted a cross-sectional study of 1403 Chinese children living in the East Coast of China in 2014. Read More

    The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules.
    Int J Endocrinol 2017 7;2017:3145234. Epub 2017 Sep 7.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
    Aim: Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. Read More

    Clinically significant cancer rates in incidentally discovered thyroid nodules by routine imaging.
    J Surg Res 2017 Nov 22;219:341-346. Epub 2017 Jul 22.
    Division of Endocrine Surgery The DeWitt Daughtry Family, Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.
    Background: With widespread use of diagnostic imaging modalities, incidental thyroid nodules are frequently identified in patients for unrelated reasons. If underlying thyroid cancer risk in such patients is significant, further evaluation becomes imperative. This study evaluates the malignancy rate of incidentally discovered compared to clinically apparent thyroid nodules in surgical patients. Read More

    Diagnostic potential of real-time elastography (RTE) and shear wave elastography (SWE) to differentiate benign and malignant thyroid nodules: A systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Oct;96(43):e8282
    Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Background: Real-time elastography (RTE) and shear wave elastography (SWE) are noninvasive and easily available imaging techniques that measure the tissue strain, and it has been reported that the sensitivity and the specificity of elastography were better in differentiating between benign and malignant thyroid nodules than conventional technologies.

    Methods: Relevant articles were searched in multiple databases; the comparison of elasticity index (EI) was conducted with the Review Manager 5.0. Read More

    [Diagnostic efficacy of (18)F-FDG PET-CT for focal hypermetabolic thyroid nodules].
    Zhonghua Zhong Liu Za Zhi 2017 Oct;39(10):759-763
    Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Molecular Imaging Precision Medicine Collaborative Innovation Center of Shanxi Province, Taiyuan 030001, China.
    Objective: To explore the diagnostic efficacy of by (18)F-FDG PET-CT for hypermetabolic thyroid nodules. Methods: To retrospectively analyze the clinical data of 3 192 patients underwent (18)F-FDG PET-CT in our hospital from May 2012 to October 2014. Among them, 98 patients were diagnosed with focal hypermetabolic thyroid nodules. Read More

    Hyalinizing trabecular tumor of the thyroid gland and its significant diagnostic issue.
    Thyroid Res 2017 10;10. Epub 2017 Oct 10.
    Department of Otolaryngology Head and Neck Surgery, OhioHealth Doctors Hospital, 5100 W Broad Street, Columbus, OH 43228 USA.
    Background: Hyalinizing trabecular tumors (HTT) are rare follicular cell-derived tumors of the thyroid gland that are infrequently reported in otolaryngology literature. We present here an interesting case of HTT which provides the basis for review of this entity's clinical characteristics, criteria useful in making the diagnosis, and any currently available therapeutic modalities.

    Case Presentation: A 70-year-old Caucasian female underwent a CT scan of her chest and was incidentally found to have a nodule within the right thyroid lobe. Read More

    Qualitative and Semiquantitative Elastography for the Diagnosis of Intermediate Suspicious Thyroid Nodules Based on the 2015 American Thyroid Association Guidelines.
    J Ultrasound Med 2017 Oct 16. Epub 2017 Oct 16.
    Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, Seoul, Korea.
    Objectives: To evaluate qualitative and semiquantitative elastography for the diagnosis of intermediate suspicious thyroid nodules based on the 2015 American Thyroid Association (ATA) guidelines.

    Methods: Through a retrospective search of our institutional database, 746 solid thyroid nodules found on grayscale ultrasonography, strain elastography, and ultrasound-guided fine-needle aspiration between June and November 2009 were collected. Among them, 80 nodules from 80 patients with an intermediate suspicion of malignancy based on the 2015 ATA guidelines that were 10 mm or larger were recruited as the final study nodules. Read More

    Preoperative diagnostics in differentiated thyroid carcinoma.
    Nuklearmedizin 2017 Oct 18;56(6). Epub 2017 Oct 18.
    PD Dr. med. Martin Freesmeyer, Clinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany, Phone: +49-3641-9329801, Fax: +49-3641-9329802, Email:
    Aim: The preoperative diagnosis of differentiated thyroid carcinomas (DTC) is particularly challenging in view of the high prevalence of thyroid nodules in the general population. Incidental diagnosis of DTC, on the other hand, can lead to reoperations and increased risk of morbidity. This study aimed to assess the prediction value of preoperative DTC dignity assessment and it's impact on surgical approaches. Read More

    Differential Growth Rates of Benign versus Malignant Thyroid Nodules.
    J Clin Endocrinol Metab 2017 Oct 12. Epub 2017 Oct 12.
    The Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, The Brigham & Women's Hospital and Harvard Medical School, Boston, MA.
    Context: Thyroid nodule growth was once considered concerning for malignancy, but data showing that benign nodules grow questioned the utility of this paradigm. To date, however, no studies have adequately evaluated if growth rates differ in malignant versus benign nodules.

    Objective: To sonographically evaluate growth rates in benign and malignant thyroid nodules ≥1cm. Read More

    Transoral endoscopic thyroidectomy via a vestibular approach: why and how?
    Endocrine 2017 Oct 16. Epub 2017 Oct 16.
    Department of Surgery, Korea University College of Medicine, Seoul, Korea, Anam Hospital, Seoul, Korea.
    The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a novel, scar-free surgical procedure that does not require visible incisions. Indications for TOETVA are as follows: predicted gland width on diagnostic imaging ≤10 cm; a thyroid volume outline of <45 mL or dominant nodule dimension of ≤50 mm; three or four Bethesda lesions; a primary papillary microcarcinoma without local or distant metastasis; and patient request for optimal esthetic results. Contraindications are as follows: patients unfit for general anesthesia; precedent radiation in the head, neck, upper mediastinum; antecedent neck surgery; recurrent goiter; a gland volume of >45 mL or main nodule diameter of >50 mm; and documentation of lymph node or distant metastases, tracheal/esophageal infiltration, preoperative laryngeal nerve palsy, hyperthyroidism, mediastinal goiter, or an oral abscess. Read More

    Surgical management of primary hyperparathyroidism.
    Eur Arch Otorhinolaryngol 2017 Dec 16;274(12):4225-4232. Epub 2017 Oct 16.
    Departments of Otolaryngology, Royal Victoria Eye and Ear Hospital, Dublin 2, Ireland.
    We reviewed the surgical management of primary hyperparathyroidism through a retrospective chart review of 200 parathyroidectomy procedures performed over a 12 year period. Epidemiological data and accuracy of radiological investigations used in identifying pathological parathyroid tissue location were assessed. We determined how often simultaneous removal of thyroid tissue was required during parathyroidectomy and the associated pathology. Read More

    Factors influencing the outcome from ultrasonography-guided fine-needle aspiration of benign thyroid cysts and partially cystic thyroid nodules: A multicenter study.
    Endocr Res 2017 Oct 16:1-8. Epub 2017 Oct 16.
    g Department of Radiology , Chung-Ang University Hospital, Chung-Ang University College of Medicine , Seoul , South Korea.
    Purpose: The effect of ultrasonography (US)-guided fine-needle aspiration (US-FNA) for the collapse of benign cystic thyroid nodules is still unclear. This study aimed to assess the positive response rate following US-FNA of the cystic component of thyroid cysts and of partially cystic thyroid nodules (PCTNs), and to evaluate the factors influencing the outcome.

    Methods: From June to December 2013, seven radiologists at seven institutions prospectively performed US-FNA on 320 cystic thyroid nodules in 320 patients. Read More

    An update on the status of molecular testing for the indeterminate thyroid nodule and risk stratification of differentiated thyroid cancer.
    Curr Opin Oncol 2017 Oct 11. Epub 2017 Oct 11.
    Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
    Purpose Of Review: Correct identification of malignancy in cytologically indeterminate thyroid nodules is a diagnostic challenge, leading to potentially unnecessary surgery in patients for whom final histology is benign. Similarly, many patients with differentiated thyroid cancer (DTC) undergo aggressive surgical management of tumors, which may ultimately have low-risk histologic features. Use of molecular testing strategies can aid in both the diagnosis of indeterminate thyroid nodules and preoperative risk stratification of DTC. Read More

    Pathologic significance of a novel oncoprotein in thyroid cancer progression.
    Head Neck 2017 Dec 11;39(12):2459-2469. Epub 2017 Oct 11.
    Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, California.
    Background: The incidence of thyroid cancer is increasing worldwide, and there is an emerging need to develop accurate tools for diagnosis. Fine needle aspiration biopsy has greatly improved evaluation of thyroid nodules, but challenges with indeterminate lesions remain in up to 25% of biopsies. Novel tissue biomarkers may assist in improved nodule characterization. Read More

    Intrathyroidal carotid artery and nonrecurring right recurrent laryngeal nerve: A case report.
    Head Neck 2017 Dec 11;39(12):E123-E126. Epub 2017 Oct 11.
    Department of Surgery, Division of Otolaryngology - Head and Neck Surgery The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania.
    Background: When performing thyroidectomy, knowledge of normal anatomy and variants is vital to avoid injuring nearby structures. Typically, the bilateral carotids course posterolateral to the thyroid gland. We describe a rare variant of an intrathyroidal carotid artery, not previously described in the literature. Read More

    Sonographic Evaluation of Pediatric Thyroid Nodules.
    Radiographics 2017 Oct;37(6):1731-1752
    From the Department of Radiology (A.C.E., S.C.K., M.P.D., Y.S.) and Stead Family Department of Pediatrics (L.M.P.), University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52246; the University of Central Florida College of Medicine, Orlando, Fla (P.H.J.); and the Department of Radiology, Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (M.E., C.M.J., D.J.P.).
    A thyroid nodule detected clinically or incidentally at medical imaging is a common indication for ultrasonography (US) in the adult population. This scenario is less frequently the case in pediatric patients, and the approach to evaluation of thyroid nodules deserves modification in these patients because of the increased probability of malignancy in children, compared with adults. Evaluating a thyroid nodule with US in a systematic way requires familiarity with a number of features that can be assessed and the terms that the radiologist uses in each category. Read More

    Propensity score-matched analysis of the endoscopic bilateral axillo-breast approach (BABA) versus conventional open thyroidectomy in patients with benign or intermediate fine-needle aspiration cytology results, a retrospective study.
    Int J Surg 2017 Oct 7;48:9-15. Epub 2017 Oct 7.
    Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background: The purpose of this study was to compare the surgical outcomes of endoscopic bilateral axillo-breast approach (BABA) to conventional open thyroidectomy (COT) in patients who had thyroid nodule(s) with a benign or intermediate fine-needle aspiration cytology (FNAC) results.

    Materials And Methods: All patients with benign or intermediate thyroid nodule(s) who underwent BABA (n = 95) or COT (n = 262) between 2008 and 2015 were reviewed. Then, 1:1 propensity score matching was performed, and 66 matched pairs were obtained. Read More

    Could Red Cell Distribution Width be a Marker of Thyroid Cancer?
    J Coll Physicians Surg Pak 2017 Sep;27(9):556-558
    Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
    Objective: To study red cell distribution width (RDW) values, a novel inflammatory marker in routine hemogram, of patients with benign or malignant thyroid nodules and to compare with healthy population.

    Study Design: Descriptive study.

    Place And Duration Of Study: Abant Izzet Baysal University Hospital, Bolu, Turkey, from November 2015 and February 2017. Read More

    Thyroid Fine Needle Aspiration Cytology Practice in Korea.
    J Pathol Transl Med 2017 10 11. Epub 2017 Oct 11.
    Department of Pathology, Inje University Ilsan Paik Hospital, Ilsan, Korea.
    We reviewed the current status of thyroid fine needle aspiration cytology (FNAC) in Korea. Thyroid aspiration biopsy was first introduced in Korea in 1977. Currently, radiologists aspirate the thyroid nodule under the guidance of ultrasonography, and cytologic interpretation is only legally approved when a cytopathologist makes the diagnosis. Read More

    [Management of patients with thyroid nodules: American Thyroid Association guidelines in the setting of Czech Republic].
    Cas Lek Cesk 2017 ;156(5):241-251
    Thyroid nodules are common finding. Most of them are of benign origin without thyroid dysfunction. Diagnosis is based on evaluation of thyroid function by assessment of serum thyroid stimulating hormone, and ultrasound for the purpose to identify the nodules which should be referred to fine needle aspiration biopsy (FNAB). Read More

    Imaging and Screening of Thyroid Cancer.
    Radiol Clin North Am 2017 Nov;55(6):1261-1271
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, White 270, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:
    Ultrasound is the first-line diagnostic tool for diagnosis of thyroid diseases. The low aggressiveness of many thyroid cancers coupled with high sensitivity of sonography can lead to cancer diagnosis and treatment with no effect on outcomes. Ultrasound is recognized as the most important driver of thyroid cancer overdiagnosis. Read More

    A Pragmatic Approach to the Indeterminate Thyroid Nodule.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):751-757
    Endocrinology and Medical Education, Sri Balaji Vidyapeeth University, Puducherry, India.
    Thyroid nodules are prevalent in upto 68% of randomly selected individuals in whom high resolution ultrasound is performed. The majority of nodules are benign. The use of ultrasound coupled with FNAC has dramatically reduced the number of patients who undergo surgery for nodules. Read More

    Utility of adult-based ultrasound malignancy risk stratifications in pediatric thyroid nodules.
    Pediatr Radiol 2017 Oct 5. Epub 2017 Oct 5.
    Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.
    Background: Individual ultrasound (US) features have limited ability to distinguish benign from malignant thyroid nodules. Adult-based systems have been developed to integrate the sonographic features in an effort to improve diagnostic accuracy. None, however, has been validated in children, in whom the likelihood of malignancy is 2-5 times higher than adults. Read More

    Low Malignancy Rates in Fine-Needle Aspiration Cytologies in a Primary Care Setting in Germany.
    Thyroid 2017 Nov;27(11):1385-1392
    1 Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada .
    Background: Reported results for thyroid nodule fine-needle aspiration (FNA) cytology mainly originate from tertiary centers. However, thyroid nodule FNA cytology is mainly performed in primary care settings for which the distribution of FNA Bethesda categories and their respective malignancy rates are largely unknown. Therefore, this study investigated FNA cytology malignancy rates of a large primary care setting to determine to what extent current evidence-based strategies for the malignancy risk stratification of thyroid nodules are applied and applicable in such primary care settings. Read More

    Shear Wave Elastography in Thyroid Nodules with Indeterminate Cytology: Results of a Prospective Bicentric Study.
    Thyroid 2017 Nov;27(11):1441-1449
    10 Department of Thyroid and Endocrine Tumors Unit, Institute of Endocrinology; Pitié Salpêtrière Hospital, IUC, University Paris VI , Paris, France .
    Background: The clinical management of thyroid nodules with indeterminate cytology (IC) remains challenging. The role of shear wave elastography (SWE) in this setting is controversial. The aim of the study was to assess the performances of SWE in terms of prediction of malignancy, reproducibility, and combined analysis with ultrasound (US) examination in thyroid nodules with IC. Read More

    Incidental Tc-99m Methylene Diphosphonate Uptake in an Active Thyroid Nodule.
    Mol Imaging Radionucl Ther 2017 Oct;26(3):128-130
    University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Clinic of Endocrinology and Metabolism, Ankara, Turkey.
    Tc-99m-methylene diphosphonate (MDP) whole body scintigraphy is the method of choice for detection of metastatic bone diseases. It is primarily used to help diagnose various bone-related conditions such as primary or metastatic cancer of the bone, location of bone inflammation, and fractures that may not be visible on traditional X-ray images, as well as detection of bone damage due to infections and other conditions. In addition, bone scanning is often used for the follow-up or evaluation of response to treatment in some malignancies like prostate and breast cancers. Read More

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