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    Study of Immunohistochemical Markers (CK-19, CD-56, Ki-67, p53) in Differentiating Benign and Malignant Solitary Thyroid Nodules with special Reference to Papillary Thyroid Carcinomas.
    J Clin Diagn Res 2016 Dec 1;10(12):EC14-EC19. Epub 2016 Dec 1.
    Post Graduate Student, Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital , Pune, Maharashtra, India .
    Introduction: Solitary Thyroid Nodule (STN) has provoked increased concern owing to higher incidence of malignancy. The inter and intra observer variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas (PTC) may sometimes pose a diagnostic difficulty.

    Aim: This study was undertaken to analyse immunohistochemical (IHC) markers (CK-19, CD-56, p53, Ki-67) to differentiate between benign and malignant surgically resected STN along with their utility in the identification of PTC. Read More

    Comparative study evaluating the efficiency of cooled and uncooled single-treatment MWA in thyroid nodules after a 3-month follow up.
    Eur J Radiol Open 2017 5;4:4-8. Epub 2017 Feb 5.
    Department of Nuclear Medicine, University Hospital Frankfurt, Germany; German Centre for Thermoablation of Thyroid Nodules, University Hospital, Frankfurt, Germany.
    Objective: The aim of this study was to evaluate and compare the efficacy of single-treatment cooled and uncooled microwave ablation in thyroid nodules.

    Methods: Eighteen patients (11 women) with an average age of 62 years (range: 41-80) with 18 cold, mainly solid or solid thyroid nodules were treated with cooled or uncooled microwave ablation. Pain during the treatment was measured on a 10-point score. Read More

    Metformin and thyroid disease.
    J Endocrinol 2017 Feb 14. Epub 2017 Feb 14.
    C Liu, Endocrinology, Jiangsu Province Hospital of Integration on Chinese and Western Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China
    An intriguing area of research in thyroidology is the recently discovered association of insulin resistance with thyroid functional and morphological abnormalities. Individuals with hyperinsulinemia have larger thyroid gland and a higher prevalence of thyroid nodules and cancer. Accordingly, patients treated with metformin have a smaller thyroid volume and a lower risk of incident goiter, thyroid nodule and cancer. Read More

    Preoperative prediction of papillary thyroid microcarcinoma via multiparameter ultrasound.
    Acta Radiol 2017 Jan 1:284185117692167. Epub 2017 Jan 1.
    3 Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
    Background Accurate diagnosis of papillary thyroid microcarcinoma (PTMC) is important for further management. Ultrasound (US) is the most frequently used imaging modality for PTMC. Purpose To evaluate the diagnostic value of conventional US, contrast-enhanced ultrasound (CEUS) and real-time elastography (RTE) for patients with PTMC. Read More

    How "suspicious" is that nodule? Review of "suspicious" Afirma gene expression classifier in high risk thyroid nodules.
    Diagn Cytopathol 2017 Feb 11. Epub 2017 Feb 11.
    Department of Pathology, Hofstra Northwell Health School of Medicine, Lake Success, New York.
    Background: The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. Read More

    Concordance between the TIRADS ultrasound criteria and the BETHESDA cytology criteria on the nontoxic thyroid nodule.
    Thyroid Res 2017 2;10. Epub 2017 Feb 2.
    0000 0001 2158 6862grid.412186.8Department of surgery, Universidad del Cauca, Carrera 6 No 41 N-135 apto 202B terrazas del campestre, Popayán, Cauca Colombia.
    Background: Thyroid nodule is a common disorder of the thyroid. Despite their benign nature, they can be associated with multiple pathologic conditions, including thyroid cancer.

    Methods: This cross-sectional study determined the concordance of Ultrasound (TIRADS criteria) and Fine Needle Aspiration Biopsy (FNA-BETHESDA system) in the assessment of the nontoxic thyroid nodule. Read More

    Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA): From A to Z.
    Surg Technol Int 2017 Feb 7;30. Epub 2017 Feb 7.
    Minimally Invasive and Endocrine Surgery Division, Department of Surgery Police General Hospital, Bangkok, Thailand.
    We depict the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Patient selection criteria are (1) ultrasonographically (US) estimated thyroid diameter no larger than 10cm, (2) US estimated gland volume ≥45mL, (3) nodule size ≥5mm, (4) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter, (5) follicular neoplasm, and (6) papillary microcarcinoma without evidence of metastasis. TOETVA is carried out through a three-port technique placed at the oral vestibule, one 10mm port for 30° endoscope and two additional 5mm ports for dissecting and coagulating instruments. Read More

    Frontal bone metastasis from an occult follicular thyroid carcinoma: Diagnosed by FNAC.
    J Cytol 2017 Jan-Mar;34(1):59-61
    Department of Pathology, PGIMS, Rohtak, India.
    Metastatic deposits in skull bones from follicular thyroid carcinoma is rare, and metastatic disease in skull being the presenting symptom without obvious thyroid lesion (occult primary) is even rarer. A 60-year-old female patient presented with a mass in the frontal region of the skull. Fine needle aspiration cytology was done which revealed an adenocarcinoma with repeated follicular pattern, reminiscent of follicular neoplasm of thyroid, which on immunocytochemistry revealed positivity for thyroglobulin. Read More

    Incidentally Found Postoperative Spindle Cell Nodule of the Breast 6 Months After Ultrasound-Guided Vacuum-Assisted Excision.
    Ultrasound Q 2017 Feb 9. Epub 2017 Feb 9.
    *Department of Medicine, Graduate School, Kyung Hee University, and †Department of Radiology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, South Korea.
    Postoperative spindle cell nodule (PSCN) is a very rare pathologic complication that can occur in association with a recent core needle biopsy, surgery, or trauma. Cases of PSCN have been reported in the lower genitourinary tract, endometrium, and thyroid but are rare in the breast. Herein, we report an ultrasound-guided biopsy-proven PSCN after ultrasound-guided vacuum-assisted excision in the breast. Read More

    Risk of Malignancy in Thyroid Nodules 4 cm or Larger.
    Endocrinol Metab (Seoul) 2017 Feb 8. Epub 2017 Feb 8.
    Department of Otolaryngology, Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
    Background: Several authors have questioned the accuracy of fine-needle aspiration cytology (FNAC) in large nodules. Some surgeons recommend thyroidectomy for nodules ≥4 cm even in the setting of benign FNAC, due to increased risk of malignancy and increased false negative rates in large thyroid nodules. The goal of our study was to evaluate if thyroid nodule size is associated with risk of malignancy, and to evaluate the false negative rate of FNAC for thyroid nodules ≥4 cm in our patient population. Read More

    Anaplastic thyroid carcinoma and foscarnet use in a multitarget treatment documented by 18F-FDG PET/CT: A case report.
    Medicine (Baltimore) 2017 Feb;96(6):e5621
    aDepartment of Experimental Medicine bDepartment of Internal Medicine and Clinical Specialities cDepartment of Radiology, Anatomopathology and Oncology, Sapienza University of Rome, Rome dNuclear Medicine Unit, Department of Interventional Oncology, Azienda Ospedaliera Ospedale di Circolo di Busto Arsizio Varese, Busto Arsizio, Varese, Italy.
    Rationale: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC).

    Patient Concerns: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC). Read More

    Determining Patient Preferences for Indeterminate Thyroid Nodules: Observation, Surgery or Molecular Tests.
    World J Surg 2017 Feb 7. Epub 2017 Feb 7.
    Department of Otolaryngology - Head and Neck Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
    Background: Gene-expression classifiers (GEC) and genetic mutation panels (GMP) have been shown to improve preoperative diagnostic evaluations of indeterminate thyroid nodules. Despite the improvement, uncertainty regarding the proper management exists. Patient preferences may better inform the management of these indeterminate thyroid nodules. Read More

    The Utility of Intraoperative Frozen Section for The Evaluation of Microscopic Extrathyroidal Extension in Papillary Thyroid Carcinoma.
    Clin Otolaryngol 2017 Feb 6. Epub 2017 Feb 6.
    Department of Otolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Korea.
    Objectives: This study is designed to evaluate the usefulness of intraoperative frozen section for the evaluation of microscopic extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC).

    Design: Retrospective cohort study.

    Setting: Dong-A University Medical Center, Busan, Korea PARTICIPANTS: Three hundred sixty-four patients who underwent thyroid surgery from January 2000 to December 2010, with PTC confined to one unilateral lobe as diagnosed using preoperative ultrasonography were enrolled. Read More

    Virtual touch tissue imaging and quantification (VTIQ) in the evaluation of thyroid nodules: the associated factors leading to misdiagnosis.
    Sci Rep 2017 Feb 3;7:41958. Epub 2017 Feb 3.
    Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai 200072, China.
    To evaluate the associated factors leading to misdiagnosis with VTIQ for differentiation between benign from malignant thyroid nodules (TNs). The study included 238 benign TNs and 150 malignant TNs. Conventional ultrasound (US) features and VTIQ parameters were obtained and compared with the reference standard of histopathological and/or cytological results. Read More

    Risk of malignancy in fine-needle aspiration biopsy in patients with thyroid nodules.
    Dan Med J 2017 Feb;64(2)
    Introduction: Fine-needle aspiration biopsy (FNAB) is the cornerstone of thyroid nodule evaluation. In most cases, FNAB can discriminate between benign and malignant disease. In other cases, it is only indicative of malignancy and the results are considered "suspicious". Read More

    What Is the Ideal Core Number for Ultrasonography-Guided Thyroid Biopsy of Cytologically Inconclusive Nodules?
    AJNR Am J Neuroradiol 2017 Feb 2. Epub 2017 Feb 2.
    From the Department of Radiology and Center for Imaging Science (S.Y.H., J.H.S.) and Department of Pathology (Y.L.O.), Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background And Purpose: Core needle biopsy of the thyroid under ultrasonographic guidance provides a larger tissue sample and may facilitate a more precise histologic diagnosis, reducing the need for repetitive fine-needle aspiration or a diagnostic operation. However, there is no consensus regarding the ideal number of specimens to be obtained for ultrasonography-guided core needle biopsy. The aim of this study was to decide the ideal core number for ultrasonography-guided core needle biopsy of cytologically inconclusive nodules. Read More

    Hepatic lesions in a cirrhotic liver: primary or metastases?
    J Nucl Med Technol 2017 Feb 2. Epub 2017 Feb 2.
    Nuclear Medicine, Department of Radiology,, United States.
    Although prior studies showed that patients with cirrhosis have a lower risk of developing liver metastases, appropriate work-up of incidental liver masses in cirrhotic liver is important for a correct diagnosis. Here we present a case of newly diagnosed liver cirrhosis with multifocal hepatic lesions which was initially categorized as LI-RADS 5 lesions. Scintigraphy with Octreoscan indicate a suspicious thyroid nodule, later confirmed to represent a medullary thyroid carcinoma lesion. Read More

    Qualifiers of atypia in the cytologic diagnosis of thyroid nodules are associated with different Afirma gene expression classifier results and clinical outcomes.
    Cancer 2017 Feb 2. Epub 2017 Feb 2.
    Thyroid Section, Division of Endocrinology, Hypertension, and Diabetes, The Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
    Background: Thyroid nodules with atypia of undetermined significance (AUS) on fine-needle aspiration (FNA) have a low risk of malignancy that appears to vary based on specific features described in the AUS diagnosis. The Afirma gene expression classifier (GEC) is a molecular test designed to improve preoperative risk stratification of thyroid nodules, but its performance for different patterns of AUS has not been defined. The objective of this study was to assess GEC results and clinical outcomes in AUS nodules with architectural atypia (AUS-A), cytologic atypia (AUS-C) or both (AUS-C/A). Read More

    Trans-oral glasses-free three-dimensional endoscopic thyroidectomy-preliminary single center experiences.
    Gland Surg 2016 Dec;5(6):628-632
    Department of Thoracic Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
    Glass-free three-dimensional (3D) endoscopic provide excellent depth perception without decreasing light quality and fog formation. Herein we report our first case-serial of trans-oral endoscopic thyroidectomy by means of our newly developed glasses-free 3D endoscopic system. Four patients with thyroid goiter undergone trans-oral glasses-free 3D endosocpic thyroidectomy were reviewed. Read More

    Transoral endoscopic thyroidectomy via vestibular approach: operative steps and video.
    Gland Surg 2016 Dec;5(6):625-627
    Department of Surgery, Police General Hospital, Faculty of Medicine, Siam University, Pathumwan, Bangkok, Thailand.
    In this video we describe transoral endoscopic thyroidectomy vestibular approach (TOETVA). Inclusion criteria are (I) patients who had a ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US estimated gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without evidence of metastasis. The procedure is carried out through three-port technique placed at the oral vestibule, one 10-mm port for 30° endoscope and two additional 5-mm ports for dissecting and coagulating instruments. Read More

    Is vascular flow a predictor of malignant thyroid nodules? A meta-analysis.
    Gland Surg 2016 Dec;5(6):576-582
    Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.
    Background: Several reports have proposed that increased vascular flow on color Doppler sonography may be associated with malignancy in thyroid nodules. Others have described no correlation between the presence of flow and risk of malignancy. The purpose of this study was to determine whether the vascularity of a thyroid nodule can aid in the prediction of malignancy by performing a meta-analysis of the current literature. Read More

    Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments?
    Gland Surg 2016 Dec;5(6):553-558
    Department of Radiology, San Paolo Hospital, Milan, Italy.
    Background: Thyroid nodules are a fairly common finding in general population and, even if most of them are benign, a treatment can be however necessary. In the last years, non surgical minimally invasive techniques have been developed to treat this pathology, starting from percutaneous ethanol injection (PEI), to laser ablation (LA), radiofrequency ablation (RFA) and, most recently, microwave ablation (MWA).

    Methods: We reviewed all medical literature searching in pubmed. Read More

    Horner Syndrome Secondary to Thyroid Surgery.
    Case Rep Endocrinol 2017 4;2017:1689039. Epub 2017 Jan 4.
    Department of Pediatric Surgery, School of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.
    Horner syndrome (HS), caused by an interruption in the oculosympathetic pathway, is characterised by myosis, ipsilateral blepharoptosis, enophthalmos, facial anhydrosis, and vascular dilation of the lateral part of the face. HS is a rare complication of thyroidectomy. A 15-year-old female patient presented with solitary solid and large nodule in the right thyroid lobe. Read More

    [A Case of Minimal Thyroid Carcinoma Diagnosed by a Solitary Pulmonary Metastasis].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2127-2129
    Dept. of Surgery, Okayama Rosai Hospital.
    We report a case of minimal thyroid carcinoma diagnosed by a solitary pulmonary metastasis. A 70's man visited a medical practitioner because of chest discomfort, and there was an abnormality on the chest X-ray. Chest computed tomography(CT) showed a nodule in the right middle lobe of the lung. Read More

    Epithelioid hemangioendothelioma of the thyroid: a case report.
    Surg Case Rep 2017 Dec 28;3(1):18. Epub 2017 Jan 28.
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Background: Epithelioid hemangioendothelioma (EHE) of the thyroid is an extremely rare disease; only three cases have been reported in the English literature to date. Here, we describe a case involving a patient with thyroid EHE successfully treated with curative surgery.

    Case Presentation: A 74-year-old woman presented with a right thyroid mass. Read More

    False-positive cytopathology results for papillary thyroid carcinoma: A trap for thyroid surgeons.
    Clin Otolaryngol 2017 Jan 28. Epub 2017 Jan 28.
    Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
    Objectives: Current preoperative diagnosis of thyroid nodules remains imperfect despite recent advances in cytopathology and molecular diagnostics. False-positivity in preoperative fine needle aspiration cytology (FNAC) may lead to overtreatment of patients, including total thyroidectomy, and sometimes to lawsuits for misdiagnosis and malpractice. In this study, we analyzed clinical characteristics and pathologic findings in patients with false-positivity for papillary thyroid carcinoma (PTC) in FNAC. Read More

    Metachronous solitary metastasis to the thyroid gland from squamous cell carcinoma of the lung: a case report and literature review.
    Tumori 2017 Jan 23. Epub 2017 Jan 23.
     Medical Oncology Unit, Policlinico S. Orsola-Malpighi, Bologna - Italy.
    Introduction: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. Read More

    Ultrasound risk stratification for malignancy using the 2015 American Thyroid Association Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
    Pediatr Radiol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Radiology, Loyola University Chicago Stritch School of Medicine, 2160 S. First Ave., Maywood, IL, 60546, USA.
    Background: The 2015 American Thyroid Association (ATA) Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer provides selection criteria for nodules prior to ultrasound-guided fine-needle aspiration biopsy.

    Objective: To evaluate the diagnostic performance of pediatric thyroid nodule risk stratification for predicting malignancy when applying the ultrasound (US) criteria recommended.

    Materials And Methods: US characteristics of 39 thyroid nodules in 33 pediatric patients who underwent US fine-needle aspiration biopsy were reviewed by two radiologists. Read More

    Elastography in Distinguishing Benign from Malignant Thyroid Nodules.
    J Clin Imaging Sci 2016 29;6:51. Epub 2016 Dec 29.
    Department of Radiology, Florence Nightingale Hospital, Istanbul, Turkey.
    Aim: The aim of this study is to test the diagnostic success of strain elastography in distinguishing benign from malignant thyroid nodules.

    Materials And Methods: The size, echogenicity, and halo integrity of 293 thyroid nodules and the presence of microcalcification in these nodules were evaluated on gray-scale examination. Doppler characteristics and elastography patterns were also evaluated and recorded. Read More

    A Rare and Severe Complication Following Thyroid Fine Needle Aspiration: Retropharyngeal Cellulitis.
    Int J Endocrinol Metab 2016 Oct 22;14(4):e39174. Epub 2016 Aug 22.
    Department of Endocrinology, University Campus Bio-Medico, Rome, Italy.
    Introduction: Fine needle aspiration (FNA) is the most accurate and cost-effective method for evaluating thyroid nodules. We have reported a rare complication related to the procedure: severe retropharyngeal cellulitis.

    Case Presentation: A thirty-five-year-old female was admitted to hospital with hoarseness, laryngeal stridor and dyspnea without fever that emerged about 3 days after a first diagnostic FNA. Read More

    Thyroid Ultrasound-Guided Fine-Needle Aspiration Cytology Results.
    Otolaryngol Head Neck Surg 2017 Jan 1:194599816688190. Epub 2017 Jan 1.
    1 Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati (UC) College of Medicine, Cincinnati, Ohio, USA.
    Objectives To evaluate changes in distribution of reported thyroid nodule fine-needle aspiration (FNA) cytopathology results since implementation of the Bethesda classification and revised 2015 American Thyroid Association (ATA) guidelines for selecting nodules for biopsy. Study Design Retrospective review. Setting Tertiary academic medical center. Read More

    Molecular Profiling of Thyroid Nodules: Current Role for the Afirma Gene Expression Classifier on Clinical Decision Making.
    Mol Imaging Radionucl Ther 2016 Jan;26(Suppl 1):36-49
    Veracyte, Inc., Department of Medical Affairs, Senior Medical Director-Endocrinology, California, USA, Phone: +1(650)243-6300, E-mail:
    Thyroid fine-needle aspiration biopsy results are cytologically indeterminate in 15-30% of cases. When these nodules undergo diagnostic surgery, approximately three-quarters are histologically benign. These unnecessary surgeries diminish quality of life, generate complications, and increase healthcare costs. Read More

    NIFTP Accounts for Over Half of "Carcinomas" Harboring RAS Mutations.
    Thyroid 2017 Jan 23. Epub 2017 Jan 23.
    Brigham and Women's Hospital, Pathology , 75 Francis Street , Boston, Massachusetts, United States , 02115 ;
    Background: Molecular testing of thyroid nodules is increasingly being utilized to guide clinical management decisions. RAS mutations are the most frequent mutations detected in the context of an indeterminate fine needle aspiration (FNA) diagnosis. The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently introduced to promote conservative management of tumors previously classified as noninvasive follicular variant of papillary thyroid carcinoma (FVPTC). Read More

    BRAF(K601E) Mutation in a Follicular Thyroid Adenoma.
    Int J Surg Pathol 2017 Jan 1:1066896916688083. Epub 2017 Jan 1.
    1 University of Pisa, Pisa, Italy.
    BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. Read More

    Characteristics of incidentally found thyroid nodules in computed tomography: comparison with thyroid scintigraphy.
    BMC Med Imaging 2017 Jan 21;17(1). Epub 2017 Jan 21.
    Department of Radiology, Paracelsus Medical University of Salzburg, Salzburg, Austria.
    Background: In our daily experience, the differentiation between a cold and hot nodule is a very important factor for further clinical management of the patient. In this study, we compared the characteristics of incidentally found thyroid nodules detected on computed tomography (CT) to thyroid scintigraphy (TS).

    Methods: Diagnostic reports from chest CT with intravenous contrast and TS examinations performed from January 2013 to January 2016 were analyzed retrospectively. Read More

    Follicular thyroid carcinoma presenting with pathological fracture of the humerus at initial diagnosis.
    J Surg Case Rep 2017 Jan 19;2017(1). Epub 2017 Jan 19.
    Department of Otorhinolaryngology, Head and Neck Surgery, Leicester Royal Infirmary, Infirmary Square, LE1 5WW, UK.
    Differentiated carcinomas of the thyroid gland usually have a good prognosis with prognosis often discussed in terms of 20 year survival. Nevertheless its 10-year-survival rate decreases when accompanied by distant metastasis. Follicular thyroid cancer (FTC) is the second most common thyroid cancer and usually presents with a solitary thyroid nodule with or without cervical lymphadenopathy. Read More

    The prevalence of thyroid nodules in northwest China and its correlation with metabolic parameters and uric acid.
    Oncotarget 2017 Jan 18. Epub 2017 Jan 18.
    Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
    This study aimed to estimate the prevalence of thyroid nodules (TN) and investigate its correlation with metabolic parameters, especially uric acid (UA) in northwest Chinese population. We conducted a large cross-sectional survey with 67,781 residents (33,020 men, 34,761 women), aged from 18 to 86 years in Shanxi, China, from January 2012 to December 2014. A thyroid ultrasound examination was performed with number and size of nodules being recorded. Read More

    Evaluation of ThyroSeq v2 performance in thyroid nodules with indeterminate cytology.
    Endocr Relat Cancer 2017 Mar 19;24(3):127-136. Epub 2017 Jan 19.
    Department of Head and Neck-Endocrine OncologyH. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pretest risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Center from September 2014 to April 2016, in light of the new diagnostic criteria for non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Our study included 182 patients (76% female) with 190 ITNs consecutively tested with ThyroSeq v2. Read More

    Shear wave elastography and contrast-enhanced ultrasonography in the diagnosis of thyroid malignant nodules.
    Mol Clin Oncol 2016 Dec 19;5(6):724-730. Epub 2016 Oct 19.
    Department of Ultrasonography, Ningbo First Hospital, School of Medicine, Zhejiang University, Ningbo, Zhejiang 315000, P.R. China.
    The aim of the present study was to evaluate the value of shear wave elastography (SWE) and contrast-enhanced ultrasonography (CEUS) in the diagnosis of thyroid malignant nodules. A total of 253 patients with 319 thyroid nodules were subjected to two-dimensional ultrasound (2DUS) and CEUS examinations prior to thyroidectomy between March, 2014 and December, 2015. Young's modulus value for each nodule on 2DUS and CEUS images were recorded. Read More

    Metastasis of Renal Clear Cell Carcinoma to Thyroid Gland Mimicking Adenomatous Goiter.
    Pol J Radiol 2016 25;81:618-621. Epub 2016 Dec 25.
    Department of Radiology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.
    Background: Renal cell carcinoma is an interesting tumor due to its unpredictable behavior. Common metastatic sites of renal cell carcinoma are the lungs, lymph nodes, bones and liver. Concurrent thyroid metastasis of clear cell carcinoma is uncommon but it can appear as a rapidly growing cervical, painless nodular mass. Read More

    Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology.
    Korean J Radiol 2017 Jan-Feb;18(1):217-237. Epub 2017 Jan 5.
    Department of Radiology, Dong-A University Medical Center, Busan 49201, Korea.
    Core needle biopsy (CNB) has been suggested as a complementary diagnostic method to fine-needle aspiration in patients with thyroid nodules. Many recent CNB studies have suggested a more advanced role for CNB, but there are still no guidelines on its use. Therefore, the Task Force Committee of the Korean Society of Thyroid Radiology has developed the present consensus statement and recommendations for the role of CNB in the diagnosis of thyroid nodules. Read More

    Should serum calcitonin be routinely measured in patients presenting with thyroid nodule?
    Minerva Endocrinol 2017 Jan 13. Epub 2017 Jan 13.
    Beaumont Hospital Dublin, Ireland.
    Background: The European Thyroid Association recommends serum calcitonin measurement in thyroid nodule cases. In contrast, the American Thyroid Association is ambivalent. In this institution, thyroid nodules cases are subject to a multidisciplinary evaluation of the clinical history and examination, ultrasound and scintigraphy, CT scan and sometimes MRI scan, biochemistry and histopathology of biopsies. Read More

    Factors related to recurrence of the benign non-functioning thyroid nodules after percutaneous microwave ablation.
    Int J Hyperthermia 2017 Jan 12:1-9. Epub 2017 Jan 12.
    a Department of Interventional Ultrasound , Chinese PLA General Hospital , Beijing , PR China.
    Purpose: To determine the factors affecting the recurrence of the solitary benign thyroid nodules (BTN) after microwave ablation (MWA).

    Materials And Methods: Between January 2013 and January 2015, a total of 110 patients with at least one solid thyroid nodule (solid component ≥ 80%) were enrolled. MWA was performed under continuous ultrasound (US) guidance. Read More

    The association of papillary thyroid cancer with microcalcification in thyroidnodules with indeterminate cytology based on fine-needle aspiration biopsy.
    Turk J Med Sci 2016 Dec 20;46(6):1719-1723. Epub 2016 Dec 20.
    Department of General Surgery, Faculty of Medicine, İstanbul Medeniyet University Göztepe Education and Research Hospital, İstanbul, Turkey.
    Background/aim: Microcalcifications are generally accepted as highly specific for thyroid malignancy, especially for papillary thyroid carcinoma (PTC). The aim of this study was to determine the significance of microcalcification within nodules that were classified as being of “indeterminate cytology” (IC) according to fine-needle aspiration biopsy.

    Materials And Methods: Patients who underwent thyroidectomy between January 2010 and 2013 were included in the study. Read More

    Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014).
    J Biol Regul Homeost Agents 2016 Oct-Dec;30(4):1187-1193
    Department of Surgical Sciences, “Sapienza” University of Rome, Rome, Italy.
    The new Italian cytological classification (SIAPEC 2014) of thyroid nodules, in line with those of Bethesda and BTA-RCPath, replaces the previous TIR3 class with two new classes (TIR3A and TIR3B), which correspond to different risks of malignancy and clinical actions required. The present study was conducted to evaluate the diagnostic accuracy of the new SIAPEC classification as opposed to its previous version (SIAPEC 2007). Preoperative cytology was compared with the final histology obtained from 650 consecutive patients who underwent total thyroidectomy for multinodular goiter. Read More

    Evaluation the Relationship Between Thyroid Nodule Size with Malignancy and Accuracy of Fine Needle Aspiration Biopsy (FNAB).
    Acta Inform Med 2016 Oct 1;24(5):347-350. Epub 2016 Nov 1.
    Valiasr Hospital of Kazeroon, Shiraz University of Medical Sciences, Shiraz, Iran.
    Introduction: Some studies have shown largest thyroid nodule size, especially ≥4cm that can predict malignancy and reduce fine needle aspiration biopsy (FNAB) accuracy. Therefore, this study is designed to evaluate relationship between thyroid nodule sizes with malignancy and its effect on FNBA accuracy.

    Materials And Methods: a retrospective analytical study design aims to investigate all patients with thyroid nodules who referred to surgery department of Imam-Khomeini Hospital of Mazandaran University of Medical Sciences in Sari from 20 March 2008 to 22 March 2014. Read More

    The diagnostic performance of shear wave speed (SWS) imaging for thyroid nodules with elasticity modulus and SWS measurement.
    Oncotarget 2017 Jan 6. Epub 2017 Jan 6.
    Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai 200072, China.
    To evaluate the diagnostic performance of a new technique of shear wave speed (SWS) imaging for the diagnosis of thyroid nodule with elasticity modulus and SWS measurement. 322 thyroid nodules in 322 patients (216 benign nodules, 106 malignant nodules) were included in this study. All the nodules received conventional ultrasound (US) and SWS imaging (Aplio500, Toshiba Medical Systems, Japan) before fine-needle aspiration (FNA) and/or surgery. Read More

    Cost comparison of initial lobectomy versus fine-needle aspiration for diagnostic workup of thyroid nodules in children.
    J Pediatr Surg 2016 Dec 30. Epub 2016 Dec 30.
    Division of Pediatric Surgery, Department of Surgery, Emory University School of Medicine Children's Healthcare of Atlanta, Atlanta, GA, United States. Electronic address:
    Background: Though uncommon in children, pediatric thyroid nodules carry a higher risk of malignancy than adult nodules. While fine-needle aspiration (FNA) has been well established as the initial diagnostic test in adults, it has been more slowly adopted in children. The purpose of this study was to examine the comparative cost of FNA versus initial diagnostic lobectomy (DL) in the pediatric patient with an ultrasound-confirmed thyroid nodule. Read More

    A computer-aided diagnosis system using artificial intelligence for the diagnosis and characterization of thyroid nodules on ultrasound: initial clinical assessment.
    Thyroid 2017 Jan 10. Epub 2017 Jan 10.
    University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology , 88 Olympic-ro 43-gil , Songpa-gu , Seoul, Korea, Republic of ;
    Background We describe an initial clinical assessment of a new, commercially available, computer-aided diagnosis (CAD) system using artificial intelligence (AI) for thyroid ultrasound, and evaluate its performance in the diagnosis of malignant thyroid nodules and categorization of nodule characteristics. Methods This prospective study protocol was reviewed and approved by the institutional review board. Patients with thyroid nodules with decisive diagnosis, whether benign or malignant on the basis of cytopathologic or US results, were consecutively enrolled from November 2015 to February 2016. Read More

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