11,762 results match your criteria Thyroid Nodule


A comparison of artificial intelligence versus radiologists in the diagnosis of thyroid nodules using ultrasonography: a systematic review and meta-analysis.

Eur Arch Otorhinolaryngol 2022 Jun 29. Epub 2022 Jun 29.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Thyroid nodules are common. Ultrasonography (US) is the first investigation for thyroid nodules. Artificial Intelligence (AI) is widely integrated into medical diagnosis to provide additional information. Read More

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Artery-first microwave ablation in the treatment of benign thyroid nodules.

Adv Clin Exp Med 2022 Jun 29. Epub 2022 Jun 29.

Department of Radiology, Istanbul Fatih Sultan Mehmet Training and Research Hospital, Turkey.

Background: Microwave ablation (MWA) is a safe and effective procedure for the treatment of benign thyroid nodules. The MWA causes progressive nodule shrinkage as well as the improvement of the symptoms and cosmesis. Some basic techniques have been described to further increase the efficacy and safety of this procedure. Read More

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Primary pulmonary epithelioid angiosarcoma with thyroid tumor history: A case report and literature review.

Exp Ther Med 2022 Jul 27;24(1):471. Epub 2022 May 27.

Department of Pulmonary and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.

Primary pulmonary epithelioid angiosarcoma is a rare tumor type without any specific clinical and imaging features. Therefore, it is associated with high rates of misdiagnosis. The present study reports the case of a 54-year-old female patient who was admitted after complaining of cough, expectoration and bloody sputum for >5 months in May 2021. Read More

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Development and progression of thyroid disease in PTEN hamartoma tumor syndrome: refined surveillance recommendations.

Thyroid 2022 Jun 27. Epub 2022 Jun 27.

Cleveland Clinic Foundation, Genomic Medicine Institute, 9500 Euclid Avenue, NE-30, Cleveland, Ohio, United States, 44195.

Background: PTEN hamartoma tumor syndrome (PHTS) is associated with a high prevalence and early onset of differentiated thyroid cancer and benign thyroid disease. However, a consensus on the time of initiation and frequency of thyroid cancer surveillance has not yet been reached. Most commonly, guidelines recommend annual thyroid ultrasounds, but vary widely in the time of initiation, ranging from shortly after birth to 18 years of age. Read More

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Thermography as an aid for the complementary diagnosis of nodules in the thyroid gland.

Biomed Eng Online 2022 Jun 27;21(1):41. Epub 2022 Jun 27.

Federal Technological University of Paraná/Graduate Program in Electrical Engineering and Industrial Informatics, Endereço: Av. Sete de Setembro 3165. Campus Curitiba Sede Centro, Curitiba, PR, CEP-80230-901, Brazil.

Background: Considering the estimate that thyroid cancer will become the fourth most prevalent type of tumor, improving its diagnosis is a necessity. The gold standard for evaluating thyroid nodules is ultrasound followed by biopsy. These tests, however, have limitations, especially in nodules smaller than 0. Read More

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US-CT fusion-guided percutaneous radiofrequency ablation of large substernal benign thyroid nodules.

Int J Hyperthermia 2022 ;39(1):847-854

Dipartimento di Radiologia e Ecografia Interventistica, Ospedale Evangelico Internazionale, Genova, Italy.

The aim of the present study was to assess feasibility, safety and outcome of ultrasound (US) guided percutaneous radiofrequency (RF) ablation of large substernal benign thyroid nodules assisted by US-computed tomography (CT) fusion imaging and real-time virtual needle tracking (VT) system. Thirty patients (18 females, mean age 56 y, range 32-76 y) with 35 benign nonfunctioning thyroid nodules (mean volume ± SD 26.8 ± 7. Read More

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Analysis of the Influence of Thyroid Nodule Characteristics on the Results of Shear Wave Elastography.

Front Endocrinol (Lausanne) 2022 10;13:858565. Epub 2022 Jun 10.

Department of Ultrasonography, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, The Third Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To analyze the ultrasonic characteristics of false-negative and false-positive results of shear wave elastography (SWE) in the diagnosis of thyroid nodules to clarify the influence of nodular characteristics on SWE and to guide the clinical application of SWE.

Methods: A total of 435 thyroid nodules from 343 patients with the diagnosis confirmed by surgical pathology were analyzed. Preoperative ultrasonography and SWE were conducted. Read More

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Management of thyroid nodules.

Lancet Diabetes Endocrinol 2022 Jul;10(7):540-548

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In the past 30 years, there has been a substantial rise in the detection of thyroid nodules. Largely asymptomatic, thyroid nodules are most often incidental findings that typically pose minimal risk. Data supporting these findings show a rapid rise in the incidental detection of thyroid nodules and cancer, but minimal effect on mortality rates, despite treatment. Read More

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Diagnosis of thyroid nodules.

Lancet Diabetes Endocrinol 2022 Jul;10(7):533-539

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Thyroid nodules are common, usually asymptomatic, and often pose minimal risk to the affected patient. However, 10-15% prove malignant and serve as the rationale for diagnostic assessment. Safely identifying and treating a relevant thyroid cancer through a cost-effective process is the primary goal of the treating practitioner. Read More

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Clinical and diagnostic imaging findings in a bengal tiger () with cervical spondylomyelopathy: A case report.

Rev Bras Med Vet 2022 12;44:e003921. Epub 2022 Apr 12.

Veterinarian, PhD, Head of Opsedale Veterinario San Michele, Tavazzano con Villavesco, (LO), Italy.

An adult neutered male Bengal tiger () presented with abnormal gait. Neurological examination showed poor left ambulatory hemiparesis, spontaneous proprioceptive deficit in the left anterior limb, and decreased flexor reflex in the forelimbs. The neurological symptoms suggested a caudal cervical spinal cord lesion. Read More

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[Radiofrequency ablation of benign thyroid nodules].

Laryngorhinootologie 2022 Jul 23;101(7):569-573. Epub 2022 Jun 23.

Klinik für Nuklearmedizin, Universitätsklinikum Frankfurt, Goethe-Universität Frankfurt am Main, Frankfurt am Main.

Radiofrequency ablation is an effective tool to treat benign thyroid nodules up to about 100 ml. It is well tolerated and is - together with echopulse therapy - currently the most frequently used technique in Germany for the local therapy of benign thyroid nodules. Overall, a volume reduction of about 50 % to 70 % can be expected. Read More

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[The Echotherapy as non-invasive treatment option for thyroid diseases].

Laryngorhinootologie 2022 Jul 23;101(7):562-568. Epub 2022 Jun 23.

Zentrum für Nuklearmedizin und PET/CT, Bremen.

Focused ultrasound is becoming more and more important when it comes to its application in thyroid diseases due to the development of echotherapy. This article provides insights in the application of echotherapy and the treatment process as well as clinical experiences and future perspectives. Studies have already been able to show significant volume reductions and improvement of symptoms after the treatment of benign and symptomatic thyroid nodules. Read More

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Health-related quality of life following FDG-PET/CT for cytological indeterminate thyroid nodules.

Endocr Connect 2022 Jun 1. Epub 2022 Jun 1.

D Vriens, Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, Netherlands.

Objective: This study assessed the health-related quality of life (HRQoL) in patients undergoing FDG-PET/CT for an indeterminate (Bethesda III/IV) thyroid nodule. FDG-PET/CT accurately rules out malignancy and prevents 40% of futile diagnostic surgeries in these nodules.

Design: Secondary analyses of HRQoL data from a randomised controlled multicentre trial (NCT02208544) in 126 patients from 15 hospitals in the Netherlands. Read More

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Clinicopathologic features of thyroid nodules with PTEN mutations on preoperative testing.

Endocr Relat Cancer 2022 Jun 1. Epub 2022 Jun 1.

E Morariu, Department of Medicine, University of Pittsburgh, Pittsburgh, United States.

The incidence of cancer in thyroid nodules carrying germline or somatic PTEN mutations is not well defined. This study characterizes clinical and histopathologic features of thyroid nodules with preoperatively detected PTEN mutations and their impact on management. Thyroid nodules with PTEN mutations on molecular testing of fine needle aspirate (FNA) specimens from November 2017 to July 2020 at our institution were included. Read More

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Molecular Testing for Indeterminate Thyroid Nodules: Association of Negative Predictive Value With Nodule Size.

Am Surg 2022 Jun 19:31348221109489. Epub 2022 Jun 19.

Department of Surgery, 528756Wake Forest Baptist Health, Winston-Salem, NC, USA.

Background: Molecular testing helps stratify risk of malignancy in indeterminate thyroid nodules, but it may be limited in its ability to rule out malignancy in large nodules.

Methods: We compared small thyroid nodules (<4 cm) to large thyroid nodules (4 cm or greater) in a retrospective, single center, cohort study of indeterminate thyroid nodules analyzed with ThyroSeq from 10/2015 through 4/2020. Our primary outcome was negative predictive value. Read More

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Assessment of diagnostic capacity and decision-making based on the 2015 American Thyroid Association ultrasound classification system.

World J Methodol 2022 May 20;12(3):148-163. Epub 2022 May 20.

Thyroid Clinic, General Surgery Service, Hospital General de Mexico, Mexico 06726, Mexico.

Background: This study evaluates the American Thyroid Association (ATA) ultrasound (US) classification system for the initial assessment of thyroid nodules to determine if it indeed facilitates clinical decision-making.

Aim: To perform a systematic review and meta-analysis of the diagnostic value of the ATA US classification system for the initial assessment of thyroid nodules.

Methods: In accordance with the PRISMA statement for diagnostic test accuracy, we selected articles that evaluated the 2015 ATA US pattern guidelines using a diagnostic gold standard. Read More

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Head and Neck Cystic Lesions: A Cytology Review of Common and Uncommon Entities.

Acta Cytol 2022 Jun 17:1-12. Epub 2022 Jun 17.

Department of Pathology, The Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Background: Cystic lesions of the head and neck are a diagnostic challenge since they are seen in the clinical presentation of a wide variety of conditions. Herein, common and uncommon entities that present as cystic lesions in the head and neck are reviewed.

Summary: In this study, peer-reviewed articles were selected using the database PubMed, Google, Google Scholar, and Scopus. Read More

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Superb microvascular imaging for distinguishing thyroid nodules: A meta-analysis (PRISMA).

Medicine (Baltimore) 2022 Jun 17;101(24):e29505. Epub 2022 Jun 17.

Department of Ultrasound, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Background: Earlier studies have shown that the superb microvascular imaging (SMI) can detect tumor angiogenesis to distinguish thyroid nodules, but there is no systematic review. This meta-analysis aimed to identify the accuracy of ultrasound SMI for the diagnosis of thyroid nodules.

Methods: We searched PubMed, Cochrane Library, and CBM databases. Read More

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Empirical Method for Thyroid Disease Classification Using a Machine Learning Approach.

Biomed Res Int 2022 7;2022:9809932. Epub 2022 Jun 7.

University of Chinese Academy of Sciences (UCAS), Beijing, China.

There are many thyroid diseases affecting people all over the world. Many diseases affect the thyroid gland, like hypothyroidism, hyperthyroidism, and thyroid cancer. Thyroid inefficiency can cause severe symptoms in patients. Read More

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Update regarding the role of PD-L1 in oncocytic thyroid lesions on cytological samples.

J Clin Pathol 2022 Jun 14. Epub 2022 Jun 14.

Anatomic Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy

Aims: Several papers have shown that programmed death-ligand 1 (PD-L1) expression is a relevant predictive biomarker in anti-PD-L1 cancer immunotherapy. While its role in several human cancers is correlated with poor prognosis and resistance to anticancer therapies, in thyroid cancers the role of PD-L1 remains questionable. Few articles have studied PD-L1 in thyroid fine-needle aspiration cytology (FNAC), demonstrating a possible correlation with papillary thyroid carcinoma. Read More

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A Practical CEUS Thyroid Reporting System for Thyroid Nodules.

Radiology 2022 Jun 14:212319. Epub 2022 Jun 14.

From the Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (J.R., X.X., M.L., W.Z., R.L., P.L., B.O., B.L.), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation (J.R., X.X., M.L., W.Z., R.L., B.O., B.L.), and Department of Otolaryngology, Head and Neck Surgery (P.L.), No. 33 Yingfeng Rd, Guangzhou 510289, China; Department of Ultrasound, Central People's Hospital of Zhanjiang, Zhanjiang, China (Y.C., Y.X.); and Department of Ultrasound, Affiliated Huadu Hospital of Southern Medical University, Guangzhou 510810, China (H.Z., Q.Y.).

Background The role of contrast-enhanced US (CEUS) in reducing unnecessary biopsies of thyroid nodules has received little attention. Purpose To construct and externally validate a thyroid imaging reporting and data system (TI-RADS) based on nonenhanced US and CEUS to stratify the malignancy risk of thyroid nodules. Materials and Methods This retrospective study evaluated 756 patients with 801 thyroid nodules who underwent nonenhanced US, CEUS, and fine-needle aspiration and received a final diagnosis from January 2018 to December 2019. Read More

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Parasitic thyroid nodules: The differential diagnosis.

Endocrinol Diabetes Nutr (Engl Ed) 2022 May;69(5):381-382

Anatomical Pathology Department, Ciudad Real General University Hospital, Ciudad Real, Spain.

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Clinicoradiological Characteristics in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid: A Multicenter Cohort Study.

Korean J Radiol 2022 Jul 31;23(7):763-772. Epub 2022 May 31.

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objective: Preoperative differential diagnosis of follicular-patterned lesions is challenging. This multicenter cohort study investigated the clinicoradiological characteristics relevant to the differential diagnosis of such lesions.

Materials And Methods: From June to September 2015, 4787 thyroid nodules (≥ 1. Read More

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Parameters of dual-energy CT for the differential diagnosis of thyroid nodules and the indirect prediction of lymph node metastasis in thyroid carcinoma: a retrospective diagnostic study.

Gland Surg 2022 May;11(5):913-926

Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: To further investigate the differential diagnosis of thyroid nodules using dual-energy computed tomography (DECT) and explore the relationship between DECT parameters and lymph node metastasis in thyroid carcinoma for clinical practice, especially difficult diagnosis by routine imaging examination.

Methods: A total of 150 patients with thyroid nodules who underwent preoperative DECT and Thyroid Imaging Report and Data System (TIRADS) classification were enrolled in this study, including 96 patients with malignant tumors and 54 with benign tumors. The DECT parameters were got form regions of interest (ROI) by an experienced radiologist team and thyroid nodules and lymph node status of all patients were identified by cytology and histopathology. Read More

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Thyroid Cancer Screening Using Tumor-Associated DN T Cells as Immunogenomic Markers.

Front Oncol 2022 27;12:891002. Epub 2022 May 27.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.

Background: Thyroid nodules are an extremely common entity, and surgery is considered the ultimate diagnostic strategy in those with unclear malignant potential. Unfortunately, strategies aiming to predict the risk of malignancy have inadequate specificity. Our group recently found that the microenvironment of thyroid cancer is characterized by an enhanced immune invasion and activated immune response mediated by double-negative T lymphocytes (DN T) (CD3CD4CD8), which are believed to enable or promote tumorigenesis. Read More

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A machine-learning algorithm for distinguishing malignant from benign indeterminate thyroid nodules using ultrasound radiomic features.

J Med Imaging (Bellingham) 2022 May 26;9(3):034501. Epub 2022 May 26.

The University of Chicago, Department of Radiology, Chicago, Illinois, United States.

: Ultrasound (US)-guided fine needle aspiration (FNA) cytology is the gold standard for the evaluation of thyroid nodules. However, up to 30% of FNA results are indeterminate, requiring further testing. In this study, we present a machine-learning analysis of indeterminate thyroid nodules on ultrasound with the aim to improve cancer diagnosis. Read More

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Total thyroidectomy versus hemithyroidectomy with intraoperative radiofrequency ablation for unilateral thyroid cancer with contralateral nodules: A propensity score matching study.

J Otolaryngol Head Neck Surg 2022 Jun 11;51(1):26. Epub 2022 Jun 11.

Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, Hubei, People's Republic of China.

Background: For unilateral papillary thyroid carcinoma (PTC) patients with contralateral benign nodules, optimal treatment decisions are made according to patient preference and the disease's pathological features. This study was performed to evaluate the efficacy and complications of hemithyroidectomy with intraoperative radiofrequency ablation (RFA) compared with total thyroidectomy.

Methods: Patients with unilateral PTC and cytologically benign contralateral nodules were enrolled from 2014 to 2018. Read More

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Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose.

J Breath Res 2022 Jun 21;16(3). Epub 2022 Jun 21.

Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

This proof-of-principle study investigates the diagnostic performance of the Aeonose in differentiating malignant from benign thyroid diseases based on volatile organic compound analysis in exhaled breath. All patients with a suspicious thyroid nodule planned for surgery, exhaled in the Aeonose. Definitive diagnosis was provided by histopathological determination after surgical resection. Read More

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Clinical Efficacy of Chinese and Western Medicine in the Treatment of Benign Thyroid Nodules: A Meta-Analysis.

Contrast Media Mol Imaging 2022 28;2022:3108485. Epub 2022 May 28.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Background: Studies have shown that Chinese herbal medicine (CHM) effectively improved the response rate and reduced the maximum nodule diameter of benign thyroid nodules (BTN). This study aimed at systematically reviewing all related studies to assess the clinical efficacy of CHM and Western medicine in the treatment of BTN.

Methods: PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for randomized controlled trials, published between 2000 and 2021, on CHM for treating BTN. Read More

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The European Institute of Oncology Thyroid Imaging Reporting and Data System for Classification of Thyroid Nodules: A Prospective Study.

J Clin Med 2022 Jun 6;11(11). Epub 2022 Jun 6.

Department of Oncology and Hematology-Oncology, University of Milan, 20122 Milan, Italy.

Background: To evaluate the performance, quality and effectiveness of "IEO-TIRADS" in assigning a TI-RADS score to thyroid nodules (TN) when compared with "EU-TIRADS" and the US risk score calculated with the S-Detect software ("S-Detect"). The primary objective is the evaluation of diagnostic accuracy (DA) by "IEO-TIRADS", "S-Detect" and "EU-TIRADS", and the secondary objective is to evaluate the diagnostic performances of the scores, using the histological report as the gold standard.

Methods: A radiologist collected all three scores of the TNs detected and determined the risk of malignancy. Read More

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