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    7973 results match your criteria Thyroid Nodule

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    Intraobserver and Interobserver Variability in Ultrasound Measurements of Thyroid Nodules.
    J Ultrasound Med 2017 Jul 24. Epub 2017 Jul 24.
    Department of Radiology, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, Seoul, Korea.
    Objectives: The purpose of this study was to assess the intraobserver and interobserver variability in ultrasound (US) measurements of thyroid nodules.

    Methods: We performed a prospective study of the US examinations of 73 patients with 122 thyroid nodules greater than 5 mm in size. Ultrasound measurements in 4 dimensions (anteroposterior, transverse, longitudinal, and maximum diameters) and measurement of the estimated volume (using the ellipsoid formula) of each thyroid nodule were performed twice by 2 independent radiologists (A and B, with 10 years and 6 months of experience, respectively). Read More

    Experience of the Implementation of Rapid On-Site Evaluation in Ultrasound-Guided Fine-Needle Aspiration Biopsy of Thyroid Nodules.
    Curr Probl Diagn Radiol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Radiology and Diagnostic Imaging, ICESI University, Cali, Colombia.
    Objective: To evaluate the effect of the implementation of the rapid on-site evaluation (ROSE) technique in ultrasound-guided fine-needle aspiration biopsy of thyroid nodules.

    Materials And Methods: We conducted an observational and retrospective study approved by the Institutional Ethics Committee as an investigation without risk. Between January 2012 and December 2015, 892 ultrasound-guided fine-needle aspiration biopsy procedures were performed under ultrasound guidance. Read More

    Differentiating malignant from benign thyroid nodules with indeterminate cytology by (99m)Tc-MIBI scan: a new quantitative method for improving diagnostic accuracy.
    Sci Rep 2017 Jul 21;7(1):6147. Epub 2017 Jul 21.
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
    Quantitative (99m)Tc-MIBI thyroid scintigraphy is a useful tool in differentiating malignant from benign thyroid nodules with indeterminate cytology. The aim of our report is to compare the diagnostic performance of different quantitative methods. We prospectively evaluated 20 patients affected by a thyroid nodule with a cytological diagnosis of class III or IV according to the Bethesda system. Read More

    Solitary splenic metastasis from lung adenocarcinoma: A case report.
    Thorac Cancer 2017 Jul 21. Epub 2017 Jul 21.
    Department of Thoracic Surgery, Osaka City University Hospital, Osaka, Japan.
    Solitary splenic metastasis is extremely rare, with only 27 reported cases in the literature. An 81-year-old woman was referred to our hospital for treatment of pulmonary and splenic lesions. Chest computed tomography showed a small lung nodule in the right upper lobe, abdominal computed tomography showed an 8 cm splenic mass with abnormal accumulation, and positron emission tomography revealed a maximum standardized uptake value of 7. Read More

    Malignancy Rates of Thyroid Cytology: Cyst Fluid Benign or Non-Diagnostic?
    Med Sci Monit 2017 Jul 21;23:3556-3561. Epub 2017 Jul 21.
    Department of General Surgery, Hitit University School of Medicine, Corum, Turkey.
    BACKGROUND We sought to investigate subgroup distribution using Bethesda classification and risks for malignancy. We also compared the malignancy risk of cases that were denoted as non-diagnostic due to cystic contents, with cases that were denoted as non-diagnostic due to presence of other features. MATERIAL AND METHODS The study included pathology test results of 1,440 thyroid nodule samples diagnosed using Bethesda classification. Read More

    Risk Stratification of Thyroid Nodules With Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS) Cytology Using Ultrasonography Patterns Defined by the 2015 ATA Guidelines.
    Ann Otol Rhinol Laryngol 2017 Jul 1:3489417719472. Epub 2017 Jul 1.
    1 Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, Seoul, Korea.
    Purpose: The purpose of this study was to evaluate the predictive value of ultrasonography (US) patterns based on the 2015 American Thyroid Association (ATA) guidelines for malignancy in atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) nodules.

    Methods: From January 2014 to August 2015, 133 thyroid nodules that were initially diagnosed as AUS/FLUS on fine needle aspiration (FNA) were included in this study. Each nodule was assigned a category with US patterns defined by the ATA guidelines. Read More

    The Effect of Routine Radiological Reporting of Thyroid Incidentalomas on Rates of Thyroid Needle Biopsy, Thyroid Surgery and Detection of Thyroid Malignancy.
    Clin Endocrinol (Oxf) 2017 Jul 18. Epub 2017 Jul 18.
    Departments of Radiology, Eastbourne District General Hospital, Endocrinology, Eastbourne District General Hospital, ENT, Eastbourne District General Hospital.
    Objective: This study looked at the effect of a changing radiology reporting policy to routinely review the thyroid gland where visible and report on any thyroid lesion, recommending further investigation as appropriate.

    Context: Incidentaloma is a term used to describe a lesion found on imaging unrelated to the clinical issue under investigation. There is variability in the radiological reporting of thyroid incidentalomas and conflicting recommendations as to how these lesions should be managed. Read More

    Thyroid nodules classified as atypia or follicular lesions of undetermined significance deserve further research: Analysis of 305 surgically confirmed nodules.
    Cytopathology 2017 Jul 17. Epub 2017 Jul 17.
    Department of General Surgery, Farabi Hospital, Karadeniz Technical University, Trabzon, Turkey.
    Objective: The objective of the present study was to determine the malignancy risk for nodules categorised as atypia or follicular lesions of undetermined significance atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) and to investigate the predictors of malignancy.

    Methods: All nodules diagnosed as AUS/FLUS on fine needle aspiration (FNAs) performed between January 2011 and December 2015 were retrospectively reviewed. Clinical data, ultrasonographic features, follow-up data and the final pathological results were recorded. Read More

    Transoral thyroidectomy: why is it needed?
    Gland Surg 2017 Jun;6(3):272-276
    Department of Surgery, Police General Hospital, Faculty of Medicine, Siam University, Bangkok, Thailand.
    Transoral thyroidectomy (TOT) represents reasonably the desirable minimally invasive approach to the gland due to the scarless non-visible incisions, the limited distance between the gland and the access that minimize tissue dissection and respect of the surgical anatomical planes. Patients are routinely selected according to an extensive inclusion criteria: (I) ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without lymph node metastasis. The operation is realized through median, central approach which allows bilateral exploration of the thyroid gland and central compartment. Read More

    Colon cancer metastasis to the thyroid gland: A case report.
    Int J Surg Case Rep 2017 Jun 28;37:221-224. Epub 2017 Jun 28.
    Centro Hospitalar e Universitário de Coimbra (Hospital Geral - Covões), S. Martinho de Bispo, 3041-853 Coimbra, Portugal. Electronic address:
    Introduction: Thyroid metastases from colorectal cancer are uncommon and few cases are described in literature.

    Case Presentation: A 64-year-old female patient presented with an asymptomatic right cervical nodule with a rapid growth six years after sigmoidectomy for cancer and two years after resection of colorectal lung metastases. Increased CA 19. Read More

    Incidental primary intradural carcinoid tumor in a patient with lumbar radiculopathy.
    World Neurosurg 2017 Jul 10. Epub 2017 Jul 10.
    Department of Neurosurgery, Beaumont Hospital, Dublin 9, Ireland.
    Background: Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Central nervous system involvement is rare. The reported cases include metastases to brain or spinal cord, as well as primary skeletal or extradural disease resulting in compressive myelo-radiculopathy. Read More

    Incidental diagnosis of the tall-cell variant of the papillary microcarcinoma of the thyroid gland requires completion lymphadenectomy: case report.
    Pol Przegl Chir 2017 Jun;89(3):40-43
    Department of General, Abdominal and Vascular Surgery, Department of Radiology and Nuclear Medicine, University Hospital Magdeburg A.ö.R., Magdeburg, Germany.
    Papillary thyroid carcinoma is the most common neoplasm of the thyroid gland which is usually associated with a very good prognosis. The aim of this case report is to present the disease course of a rare tumor of the thyroid gland, which is worthwhile due to its extraordinary appearance and specific management. A 46-year-old patient presented with a pronounced right-sided, but bilateral, multinodular goiter, with a volume of approximately 80 mL, as assessed on ultrasonography. Read More

    Role of Ultrasound in Predicting Tumor Invasiveness in Follicular Variant of Papillary Thyroid Carcinoma.
    Thyroid 2017 Jul 12. Epub 2017 Jul 12.
    Samsung Medical Center, Sungkyunkwan University, School of Medicine, Radiology, Seoul, Korea (the Republic of) ;
    Background: Follicular variant of papillary thyroid carcinoma (FVPTC) is traditionally divided into infiltrative and encapsulated types. Adding to this classification, noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP) represents a reclassification of a subset of cases (encapsulated tumors without lymphovascular or capsular invasion). The purpose of this study was to assess the role of ultrasound (US) in predicting tumor invasiveness in FVPTC. Read More

    The contemporary utility of intraoperative frozen sections in thyroid surgery.
    Am J Otolaryngol 2017 Jul 5. Epub 2017 Jul 5.
    Head and Neck Institute, Cleveland Clinic Foundation, United States. Electronic address:
    Purpose: To determine the accuracy of intraoperative frozen section analysis on thyroidectomy specimens stratified by the Bethesda classification scheme and its utility for intraoperative decision-making.

    Study Design: Retrospective chart review.

    Methods: A retrospective review was performed on all patients who underwent thyroidectomy or thyroid lobectomy with intraoperative frozen sections at a tertiary care academic center from 2009 to 2015. Read More

    Validation of the 2012 Fukuoka Consensus Guideline for Intraductal Papillary Mucinous Neoplasm of the Pancreas From a Single Institution Experience.
    Pancreas 2017 Aug;46(7):936-942
    From the *Faculty of Medicine, Department of Gastroenterological, General, Breast and Thyroid Surgery, Yamagata University, Yamagata City, Japan; and †Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Objectives: The 2012 Fukuoka consensus guideline has stratified the risks of malignant intraductal papillary mucinous neoplasm (IPMN) of the pancreas into "high-risk stigmata" (HRS) and "worrisome feature" (WF). This study aimed to evaluate its clinical validity based on a single institution experience.

    Methods: Eighty-nine patients who underwent surgical resection with pathological diagnosis of IPMN were retrospectively studied. Read More

    Thyroid Nodule Classification in Ultrasound Images by Fine-Tuning Deep Convolutional Neural Network.
    J Digit Imaging 2017 Jul 10. Epub 2017 Jul 10.
    Department of Computer Science, University of Saskatchewan, 176 Thorvaldson Bldg, 110 Science Place, Saskatoon, SK, S7N 5C9, Canada.
    With many thyroid nodules being incidentally detected, it is important to identify as many malignant nodules as possible while excluding those that are highly likely to be benign from fine needle aspiration (FNA) biopsies or surgeries. This paper presents a computer-aided diagnosis (CAD) system for classifying thyroid nodules in ultrasound images. We use deep learning approach to extract features from thyroid ultrasound images. Read More

    Follicular Thyroid Carcinoma Presenting as Large Solitary Vertebral Metastasis: Report of Two Unusual Cases Treated with Radiotherapy.
    Asia Pac J Oncol Nurs 2017 Jul-Sep;4(3):269-272
    Department of Radiation Oncology, Army Hospital Research and Referral, New Delhi, India.
    Solitary spinal metastasis with cord compression as the presenting feature of follicular thyroid carcinoma (FTC) is extremely unusual with <10 cases reported in world literature. We hereby present two such cases in a 39-year-old male with lytic lesion left sacral bone with biopsy showing metastatic carcinoma with morphology and immunophenotype of thyroid gland and a 35-year-old female with thoracic vertebral lesions suggestive of metastatic deposit of FTC. Subsequently, both patients were found to have a solitary nodule in the thyroid lobe. Read More

    The thyroid cancer epidemic, 2017 perspective.
    Curr Opin Endocrinol Diabetes Obes 2017 Jul 7. Epub 2017 Jul 7.
    aDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York City, New York bDepartment of Veterans Affairs Medical Center, VA Outcomes Group, White River Junction, Vermont; Section of Otolaryngology, Geisel School of Medicine, Dartmouth College, Hanover; The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire, USA.
    Purpose Of Review: Thyroid cancer incidence and mortality trends have been identified as being consistent with overdiagnosis, and several recent efforts have been made to mitigate this problem.

    Recent Findings: Major guidelines for thyroid nodule management recommend against general biopsy of nodules less than 1 cm in size. Data supporting the safety of active surveillance of low-risk thyroid cancers is now recognized. Read More

    Underestimated risk of cancer in solitary thyroid nodules ≥3 cm reported as benign.
    Langenbecks Arch Surg 2017 Jul 8. Epub 2017 Jul 8.
    Division of Endocrine Surgery, University of Pisa, Pisa, Italy.
    Background: The study aims to assess the risk of cancer in solitary thyroid nodules ≥30 mm in size reported as Bethesda II, and its implications.

    Method: The clinical records of 202 patients, who underwent thyroid lobectomy for solitary nodules measuring ≥30 mm, reported as Bethesda II on preoperative FNAC between Jan 2015 and Apr 2016 were reviewed. Data collected included nodule size and consistency, and final histopathology results. Read More

    Thyroid Function and Ultrasonography Abnormalities in Lithium-Treated Bipolar Patients: A Cross-sectional Study with Healthy Controls.
    Noro Psikiyatr Ars 2017 Jun 1;54(2):108-115. Epub 2017 Jun 1.
    Department of Endocrinology, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.
    Introduction: Lithium has many effects on thyroid physiology. Although these side effects have been known for a long time, large sample studies of lithium-treated patients using ultrasonography are lacking. The aim of this study is to investigate the detailed thyroid morphologies, hormone levels, and antibodies of lithium-treated patients compared with healthy controls. Read More

    Metastasis of renal cell carcinoma to the thyroid gland 9 years after nephrectomy: A case report and literature review.
    Arch Ital Urol Androl 2017 Jun 30;89(2):151-153. Epub 2017 Jun 30.
    Istanbul Medipol University, School of Medicine, Department of Urology, Istanbul.
    We report a case presenting with thyroid and lung metastases of renal cell carcinoma that was treated with molecular targeted therapy followed metastasectomy. A 52-year-old female underwent radical nephrectomy of right renal cell carcinoma in 2007. The patient presented 9 years after nephrectomy at the age of 61 years with sudden loss of vision on the left side and a mass on the neck. Read More

    The Relationship of TPOAb and TGAb with Risk of Thyroid Nodules: A Large Epidemiological Study.
    Int J Environ Res Public Health 2017 Jul 5;14(7). Epub 2017 Jul 5.
    Department of Epidemiology & Health Statistics, School of Public Health, Zhejiang University, Hangzhou 310002, China.
    Objective: The association between thyroid hormones, thyroid autoantibodies, and thyroid nodules are still not clear. The cross-sectional study, conducted in Hangzhou, China in 2010, aimed to identify the relationship of thyroid hormones and autoantibodies with thyroid nodules. Methods: Information regarding social demography was collected by a questionnaire. Read More

    Association of Preoperative Serum Thyroid-stimulating Hormone Levels with Thyroid Cancer in Patients with Nodular Thyroid Disease.
    World J Nucl Med 2017 Jul-Sep;16(3):202-205
    Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad, Pakistan.
    The aim of the current study was to determine the frequency of carcinoma thyroid among patients presenting with goiter and its association with preoperative serum thyroid-stimulating hormone (TSH) levels. A total of 73 (n = 73) adult patients of either gender with solitary solid cold nodule and multinodular goiter with predominant solid cold nodule were analyzed. All surgically resected samples were sent for histopathology. Read More

    Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration.
    Thyroid 2017 Jul 18. Epub 2017 Jul 18.
    1 Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine , Cincinnati, Ohio.
    Objective: The aim of this study was to validate the American Thyroid Association (ATA) sonographic risk assessment of thyroid nodules.

    Methods: The ATA sonographic risk assessment was prospectively applied to 206 thyroid nodules selected for ultrasound-guided fine-needle aspiration (US-FNA), and analyzed with The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), as well as surgical pathology for the subset undergoing surgical excision.

    Results: The analysis included 206 thyroid nodules averaging 2. Read More

    Results of Screening in Familial Non-Medullary Thyroid Cancer.
    Thyroid 2017 Jul 19. Epub 2017 Jul 19.
    2 Endocrine Oncology Branch, National Cancer Institute; National Institutes of Health , Bethesda, Maryland.
    Background: Although a family history of thyroid cancer is one of the main risk factors for thyroid cancer, the benefit of screening individuals with a family history of thyroid cancer is not known.

    Methods: A prospective cohort study was performed with yearly screening using neck ultrasound and fine-needle aspiration biopsy of thyroid nodule(s) >0.5 cm in at-risk individuals whose relatives were diagnosed with familial non-medullary thyroid cancer (FNMTC). Read More

    McGill Thyroid Nodule Score in Differentiating Benign and Malignant Pediatric Thyroid Nodules: A Pilot Study.
    Otolaryngol Head Neck Surg 2017 Jun 1:194599817715629. Epub 2017 Jun 1.
    7 Division of Pediatric Otolaryngology-Head and Neck Surgery, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
    Objective The McGill Thyroid Nodule Score (MTNS) is a preoperative tool used to predict the risk for well-differentiated thyroid cancer given a specific nodule in adults. We evaluated the clinical utility of a modified pediatric MTNS with children and adolescents. Study Design Case series with chart review. Read More

    Malignancy rate of focal thyroid incidentaloma detected by FDG PET-CT: results of a prospective cohort study.
    Endocr Connect 2017 Jun 25. Epub 2017 Jun 25.
    P Salaun, Nuclear Medicine, CHU Brest, Brest, France.
    Objective: To evaluate the malignancy rate of focal thyroid incidentaloma (fTI) in a population of patients undergoing a 18F-fluorodeoxyglucose positron emission tomography - computed tomography (FDG PET-CT) for a non-thyroid purpose.

    Design: We conducted a prospective cohort study from January 2013 to November 2014. All consecutive patients referred for a FDG PET-CT were prospectively screened. Read More

    A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid.
    Int J Surg Case Rep 2017 Jun 17;37:83-86. Epub 2017 Jun 17.
    Surgical Oncologist, Department of Surgery, Texas Tech University School of Medicine, Amarillo, TX, USA. Electronic address:
    Introduction: Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature EBF in the absence of EMH has been reported in the English language.

    Presentation Of Case: 63-year-old woman with an incidental finding of thyroid nodule unable to be biopsied. Read More

    Comparison of Acoustic Radiation Force Impulse Imaging and Strain Elastography in Differentiating Malignant From Benign Thyroid Nodules.
    J Ultrasound Med 2017 Jun 24. Epub 2017 Jun 24.
    Department of Medical Ultrasound, the Fourth Hospital of Hebei Medical University, Hebei, Shijiazhuang, China.
    Objectives: This study aimed to evaluate the diagnostic value of acoustic radiation force impulse (ARFI) imaging and strain elastography in differentiating malignant from benign thyroid nodules.

    Methods: This study included 128 patients (104 female and 24 male; mean age ± standard deviation, 48 ± 11 years; range, 23-76 years) with 152 pathologically proven thyroid nodules. Conventional sonography, strain ratio (SR) of strain elastography, virtual touch tissue imaging (VTI) grade, and virtual touch tissue quantification (shear wave velocity [SWV]) from ARFI imaging data were generated for each nodule. Read More

    RAS-positive thyroid nodules.
    Curr Opin Endocrinol Diabetes Obes 2017 Jul 20. Epub 2017 Jul 20.
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, The Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: The current review focuses on the uncertainty regarding the management of rat sarcoma viral oncogene homolog RAS-positive thyroid nodules. The application of oncogene testing has been heralded for improving risk assessment for indeterminate cytology thyroid nodules and has grown in clinical use. RAS mutations are historically considered oncogenic. Read More

    Treatment of benign thyroid nodules by high intensity focused ultrasound (HIFU) at different acoustic powers: a study on in-silico phantom.
    Endocrine 2017 Jun 21. Epub 2017 Jun 21.
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Via Ospedale 12, 6500, Bellinzona, Switzerland.
    Background: The non-surgical therapies of benign thyroid nodules are gaining momentum due to the possibility to reduce the nodule's volume and avoid surgery. As the last technique introduced, high intensity focused ultrasound allows the thermal tissue treatment by directing energy inside the targeted nodule with no invasive instruments. In the present study we applied the Food and Drug Administration high intensity focused ultrasound simulator to in-silico phantom to evaluate the effects obtained by different acoustic powers. Read More

    What really is an indeterminate FNA thyroid nodule?
    Ann Ital Chir 2017 Jun 12;6. Epub 2017 Jun 12.
    Background: Thyroid nodules are usually benign; however, 5 to 15% prove to be malignant. Fine-needle aspiration (FNA) has become the gold standard in the evaluation of thyroid nodules, especially in single nodule more than a centimeter and / or in smaller nodule with ultrasound characters of malignancy.

    Methods: We evaluated retrospectively 179 patients with "undetermined" thyroid fine needle aspiration, undergoing surgery. Read More

    Distinguishing parathyroid and thyroid lesions on ultrasound-guided fine-needle aspiration: A correlation of clinical data, ancillary studies, and molecular analysis.
    Cancer 2017 Jun 16. Epub 2017 Jun 16.
    Department of Pathology, New York University Langone Medical Center, New York, New York.
    Background: Differentiating parathyroid and thyroid lesions can be challenging because of considerable morphologic overlap and anatomic proximity. Therefore, the authors sought to identify characteristic morphologic patterns and useful adjunct tests to distinguish these 2 entities.

    Methods: A search was conducted in the study institution database for clinically indeterminate thyroid nodules from 2000 through 2016 with an emphasis on confirmed parathyroid nodules. Read More

    Utility of a formatted pathologic reporting system in thyroid core needle biopsy: A validation study of 1998 consecutive cases.
    Clin Endocrinol (Oxf) 2017 Jun 15. Epub 2017 Jun 15.
    Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
    Objective: Thyroid core needle biopsy (CNB) is increasingly being used as a tool for evaluating thyroid nodules; thus, standardization of its diagnostic terminology is called for. We aimed to analyse the pathologic reporting system of thyroid CNB based on the recently proposed protocol by the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group and evaluate its usefulness.

    Design/methods: A total of 1998 consecutive cases of thyroid CNBs were reviewed and divided into six categories according to the protocol. Read More

    Ultrasonographic prediction of highly aggressive telomerase reverse transcriptase (TERT) promoter-mutated papillary thyroid cancer.
    Endocrine 2017 Aug 14;57(2):234-240. Epub 2017 Jun 14.
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Purpose: Telomerase reverse transcriptase promoter mutations are found in highly aggressive thyroid malignancies. Our aim was to define the ultrasonographic features of telomerase reverse transcriptase promoter-mutated papillary thyroid cancer and to evaluate their predictive performances.

    Methods: Ultrasonographic findings were reviewed for 185 patients with surgically confirmed papillary thyroid cancer between 1994 and 2004. Read More

    Preliminary study of diffusion kurtosis imaging in thyroid nodules and its histopathologic correlation.
    Eur Radiol 2017 Jun 14. Epub 2017 Jun 14.
    Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China.
    Objectives: To evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors.

    Methods: The study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF). Read More

    Systematic differences between ultrasound and pathological evaluation of thyroid nodules: a method comparison study.
    ANZ J Surg 2017 Jun 13. Epub 2017 Jun 13.
    Endocrine Surgery Unit, Department of Surgery, Western Hospital, Melbourne, Victoria, Australia.
    Background: The size of thyroid nodules as measured by ultrasound (ultrasound size, USS) is routinely used in clinical decision-making. Reports of discrepancy between USS and pathological size (PS) evaluation have not analysed their systematic differences. The objective of this study was to uncover the lack of agreement (bias) between USS and PS measurements. Read More

    Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study.
    Mediators Inflamm 2017 21;2017:8481049. Epub 2017 May 21.
    Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
    The study is aimed to investigate the pathogenesis underlying the increased prevalence of thyroid nodule (TN) in different levels of metabolic syndrome (MetS) components and analyze the relationships between TN and MetS components. A total of 6,798 subjects, including 2201 patients with TN, were enrolled in this study. Anthropometric, biochemical, thyroid ultrasonographic, and other metabolic parameters were all measured. Read More

    A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis.
    Int J Hyperthermia 2017 Jun 12:1-9. Epub 2017 Jun 12.
    j Department of Endocrinology , "Regina Apostolorum" Hospital , Albano Laziale , Italy.
    Purpose: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules.

    Materials And Methods: Institutional review board approval was obtained, and patients' consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. Read More

    Laryngeal chondrosarcoma mimicking medullary thyroid carcinoma on fine-needle aspiration cytology: A case report of a diagnostic pitfall.
    Diagn Cytopathol 2017 Jun 11. Epub 2017 Jun 11.
    Department of Pathology and Laboratory Medicine, University of Minnesota, Minneapolis, Minnesota.
    Chondrosarcoma (CS) of larynx is a rare laryngeal tumor accounting about 1% of laryngeal malignancies. When CS arises from thyroid cartilage, it may clinically present as a thyroid nodule. Here we report a rare case of CS of thyroid cartilage misinterpreted as medullary thyroid carcinoma. Read More

    Utility of intraoperative frozen sections for thyroid nodules with prior fine needle aspiration cytology diagnosis.
    Diagn Cytopathol 2017 Jun 11. Epub 2017 Jun 11.
    Department of Pathology, Hofstra Northwell Health School of Medicine, Lake Success, New York.
    Introduction: The objective of this study was to evaluate the role of intraoperative frozen section (IFS) in determining the course of surgery in thyroid nodules with a prior fine needle aspiration (FNA) biopsy diagnosis. In addition, reliability of FNA interpretation to guide surgical management without IFS was investigated.

    Material And Methods: This is a retrospective study of all patients who had a FNA biopsy, IFS, and final pathology performed on a thyroid nodule over a 9 month period. Read More

    Thyroid nodule recognition in computed tomography using first order statistics.
    Biomed Eng Online 2017 Jun 2;16(1):67. Epub 2017 Jun 2.
    Radiology Department, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
    Background: Computed tomography (CT) is one of the popular tools for early detection of thyroid nodule. The pixel intensity of thyroid in CT image is very important information to distinguish nodule from normal thyroid tissue. The pixel intensity in normal thyroid tissues is homogeneous and smooth. Read More

    Reliability of fine needle aspiration biopsy in large thyroid nodules.
    Turk J Surg 2017 1;33(1):10-13. Epub 2017 Mar 1.
    Clinic of General Surgery, İzmir Tepecik Training and Research Hospital, İzmir, Turkey.
    Objective: Fine needle aspiration biopsy provides one of the most important data that determines the treatment algorithm of thyroid nodules. Nevertheless, the reliability of fine needle aspiration biopsy is controversial in large nodules. The aim of this study was to evaluate the adequacy of fine needle aspiration biopsy in thyroid nodules that are four cm or greater. Read More

    "Nodule in Nodule" on Thyroid Ultrasonography: Possibility of Follicular Carcinoma Transformed from Benign Thyroid Tumor.
    Eur Thyroid J 2017 Apr 13;6(2):101-107. Epub 2016 Dec 13.
    Kuma Hospital, Kobe, Japan.
    Background: It is generally considered impossible to differentiate follicular carcinomas from follicular adenomas by means of ultrasonography or cytology before surgery. Therefore, follicular carcinoma is histopathologically diagnosed by verifying capsular and/or vascular invasion after surgery. However, ultrasonography may play an important role in diagnosing follicular carcinoma preoperatively in a small number of cases. Read More

    A 2016 Italian Survey about Guidelines and Clinical Management of Thyroid Nodules.
    Eur Thyroid J 2017 Apr 29;6(2):75-81. Epub 2016 Dec 29.
    Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy.
    Background: While thyroid nodules are frequent in endocrine clinical practice, patients are often asymptomatic and euthyroid, and death is rare in cases of malignancy.

    Objectives: To evaluate the perception of current international guidelines regarding thyroid nodule management among Italian endocrinologists, and to compare daily clinical practice with suggested recommendations.

    Methods: Italian Association of Clinical Endocrinologists (AME) members were invited to participate in a Web-based survey. Read More

    Nodular Thyroid Disease and Thyroid Cancer in the Era of Precision Medicine.
    Eur Thyroid J 2017 Apr 3;6(2):65-74. Epub 2017 Mar 3.
    Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    The management of thyroid nodules, one of the main clinical challenges in endocrine clinical practice, is usually straightforward. Although the most important concern is ruling out malignancy, there are grey areas where uncertainty is frequently present: the nodules labelled as indeterminate by cytology and the extent of therapy when thyroid cancer is diagnosed pathologically. There is evidence that the current available precision medicine tools (from all the "-omics" to molecular analysis, fine-tuning imaging or artificial intelligence) may help to fill present gaps in the future. Read More

    Ultrasound-guided core needle biopsy for differential diagnosis of thyroid nodules: A systematic review and meta-analysis.
    Mol Clin Oncol 2017 Jun 8;6(6):825-832. Epub 2017 May 8.
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
    Ultrasound-guided core needle biopsy (US-CNB) of thyroid nodules is a relatively new technique used in surgical workup. However, no systematic review of this method has yet been performed. In the present meta-analysis, literature databases consisting of Cochrane Library, Medline, Embase, Scopus and Google Scholar were searched. Read More

    A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter.
    BMC Clin Pathol 2017 2;17. Epub 2017 Jun 2.
    Department of Pathology, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka City, Osaka, 543-0035 Japan.
    Background: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare.

    Case Presentation: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Read More

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