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    6780 results match your criteria Thyroid Medullary Carcinoma

    1 OF 136

    Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.
    Sci Rep 2017 Feb 23;7:43396. Epub 2017 Feb 23.
    State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Tianjin Key Laboratory of Protein Sciences and College of Life Sciences, Nankai University, Tianjin 300071, China.
    Thyroid is a one of the most important endocrine organs. Understanding the molecular mechanism underlying thyroid development and function, as well as thyroid diseases, is beneficial for the clinical treatment of thyroid diseases and tumors. Through genetic linkage analysis and exome sequencing, we previously identified an uncharacterized gene C14orf93 (RTFC, mouse homolog: 4931414P19Rik) as a novel susceptibility gene for familial non-medullary thyroid carcinoma, and demonstrated its function in promoting thyroid tumor. Read More

    Is fine needle aspiration really not necessary in patients with thyroid nodules ≤ 1 cm with highly suspicious features on ultrasonography and candidates for active surveillance?
    Diagn Cytopathol 2017 Feb 20. Epub 2017 Feb 20.
    Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    Background: The low rate of progression associated with the potential complications of thyroidectomy makes active surveillance an increasingly recommended management in low-risk papillary microcarcinomas of the thyroid (PMT). The objective of this study was to report the results of fine needle aspiration (FNA) of nodules ≤ 1 cm with highly suspicious appearance on ultrasonography (US) in patients who are potential candidates for active surveillance.

    Methods: We revised thyroid nodules ≤ 1 cm with highly suspicious appearance on US in patients without known distant metastases, suspicion of extrathyroid extension, or suspicious lymph nodes on US. Read More

    Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.
    Oncologist 2017 Feb 16. Epub 2017 Feb 16.
    Foundation Medicine, Cambridge, Massachusetts, USA.
    Background: Thyroid carcinoma, which is rare in pediatric patients (age 0-18 years) but more common in adolescent and young adult (AYA) patients (age 15-39 years), carries the potential for morbidity and mortality.

    Methods: Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements. This PAYA data series includes 41 patients with papillary thyroid carcinoma (PTC), 3 with anaplastic thyroid carcinoma (ATC), and 14 with medullary thyroid carcinoma (MTC). Read More

    Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral RET Wild-Type Neoplasm with Revision of the Literature.
    Rare Tumors 2016 Nov 20;8(4):6537. Epub 2016 Dec 20.
    Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
    Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. Read More

    [Clinical features and mutations of RET proto-oncogene in a pedigree affected with type 2A multiple endocrine neoplasia].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Feb;34(1):106-109
    Department of Endocrinology and Metabolism, Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, China.
    Objective: To investigate the clinical features and mutations of RET proto-oncogene in a pedigree affected with multiple endocrine neoplasia type 2A (MEN2A).

    Methods: Clinical data of the family members was collected. Genomic DNA from peripheral blood leukocytes were extracted and subjected to PCR amplification. Read More

    High frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma.
    Pak J Pharm Sci 2016 Nov;29(6(Suppl)):2269-2271
    Pathology Department of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    To study high-frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma (medullary thyroid carcinoma, MTC) with the purpose to improve the diagnostic accuracy of this disease. The clinical data of 20 cases of patients with MTC confirmed by the clinical surgery were retrospectively analyzed. And the high-frequency ultrasound features were analyzed and compared with the pathological characteristics. Read More

    Basal Serum Calcitonin, After Calcium Stimulation, and in the Needle Washout of Patients with Thyroid Nodules and Mild or Moderate Basal Hypercalcitoninemia.
    Horm Metab Res 2017 Feb 6;49(2):129-134. Epub 2017 Feb 6.
    Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    This prospective study evaluated the concentrations of basal serum calcitonin (Ctn), Ctn after stimulation with calcium, and Ctn in the needle washout (FNA-Ctn) as predictors of sporadic medullary thyroid carcinoma (MTC) in patients with thyroid nodules and basal Ctn between 10 and 100 pg/ml. Forty-one patients were included in the study. MTC was diagnosed in only 6 patients (14. Read More

    Search of the p.M918T Mutation in the RET Oncogene in Mexican Adult Patients with Medullary Thyroid Carcinoma.
    Exp Clin Endocrinol Diabetes 2017 Feb 6. Epub 2017 Feb 6.
    Head and Neck Cancer Deparment, National Cancer Institute, Mexico City.
    Inherited mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, predispose individuals to the multiple endocrine neoplasia type 2 (MEN 2) cancer syndromes. The major component tumor of these syndromes is medullary thyroid carcinoma (MTC). To date, somatic mutations in RET have been identified in tumors from individuals with MEN 2 finding. Read More

    Hepatic lesions in a cirrhotic liver: primary or metastases?
    J Nucl Med Technol 2017 Feb 2. Epub 2017 Feb 2.
    Nuclear Medicine, Department of Radiology,, United States.
    Although prior studies showed that patients with cirrhosis have a lower risk of developing liver metastases, appropriate work-up of incidental liver masses in cirrhotic liver is important for a correct diagnosis. Here we present a case of newly diagnosed liver cirrhosis with multifocal hepatic lesions which was initially categorized as LI-RADS 5 lesions. Scintigraphy with Octreoscan indicate a suspicious thyroid nodule, later confirmed to represent a medullary thyroid carcinoma lesion. Read More

    Multiple Endocrine Neoplasia Type 2B Unmasked by 18F-FDG PET/CT and 131I-MIBG SPECT/CT.
    Clin Nucl Med 2017 Jan 27. Epub 2017 Jan 27.
    From the Department of Nuclear Medicine, and Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
    F-FDG PET/CT was performed to detect an occult malignancy in a 26-year-old woman with complicated medical history which included paroxysmal hypertension and significantly elevated tumor marker. The images revealed lesions in the thyroid, lymph nodes, and bilateral adrenal glands. Further I-MIBG SPECT/CT revealed intense activity in the lesion in the left adrenal gland, which was consistent with pheochromocytoma. Read More

    Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib.
    Pharmacol Res 2017 Jan 25;119:89-98. Epub 2017 Jan 25.
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences,St. John's University, Queens, New York, 11439, USA. Electronic address:
    Cabozantinib (XL184) is a small molecule tyrosine kinase receptor inhibitor, which targets c-Met and VEGFR2. Cabozantinib has been approved by the Food and Drug Administration to treat advanced medullary thyroid cancer and renal cell carcinoma. In the present study, we evaluated the ability of cabozantinib to modulate the function of the ATP-binding cassette subfamily G member 2 (ABCG2) by sensitizing cells that are resistant to ABCG2 substrate antineoplastic drugs. Read More

    Gene Signature Associated with Upregulation of the Wnt/β-Catenin Signaling Pathway Predicts Tumor Response to Transarterial Embolization.
    J Vasc Interv Radiol 2017 Mar 24;28(3):349-355.e1. Epub 2017 Jan 24.
    Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, Howard-118, 1275 York Ave., New York, NY10065.
    Purpose: To identify gene mutations in tumors undergoing transarterial embolization and explore the relationship between gene mutations and tumor response to embolization.

    Materials And Methods: This was a retrospective review that included 17 patients with primary or metastatic liver tumors treated with embolization and had specimens analyzed for a 341-gene panel next-generation sequence assay. Pathologic conditions included hepatocellular, carcinoid, pancreatic neuroendocrine, melanoma, medullary thyroid, and liver acinar-cell carcinoma. Read More

    Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.
    Oncoimmunology 2016 9;5(12):e1229725. Epub 2016 Sep 9.
    Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center , Nijmegen, the Netherlands.
    Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment in non-medullary thyroid cancer (TC), the most common endocrine malignancy. However, little is known regarding the regulation of their function in TC. Transcriptome analysis in a model of TC-induced macrophages identified increased inflammatory characteristics and rewiring of cell metabolism as key functional changes. Read More

    MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit.
    Mol Cancer 2017 Jan 26;16(1):24. Epub 2017 Jan 26.
    Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Schillingallee 69, 18057, Rostock, Germany.
    Background: Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN) type 2A and 2B. These tumors are highly aggressive with a high propensity for early metastasis and chemoresistance. This attribute makes this neoplasia an excellent model for probing mechanisms underlying cancer progression. Read More

    Selective ablation of tumor suppressors in parafollicular C cells elicits medullary thyroid carcinoma.
    J Biol Chem 2017 Jan 24. Epub 2017 Jan 24.
    University of California, San Francisco, United States;
    Among the four different types of thyroid cancer, treatment of medullary thyroid carcinoma poses a major challenge due to its propensity of early metastasis. To further investigate the molecular mechanisms of medullary thyroid carcinoma and discover candidates for targeted therapies, we developed a new mouse model of medullary thyroid carcinoma based on our CGRPCreER mouse line. This system enables gene manipulation in parafollicular C cells in the thyroid, the purported cells of origin of medullary thyroid carcinoma. Read More

    [Next generation sequencing technology for susceptible gene screening in familial non-medullary thyroid carcinoma].
    Zhonghua Zhong Liu Za Zhi 2017 Jan;39(1):24-28
    Department of Thyroid and Neck Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
    Objective: To screen genes related to familial non-medullary thyroid carcinoma (FNMTC) using next-generation sequencing (NGS). Methods: A panel of NGS was designed and sequencing was performed for DNA samples extracted from peripheral blood leukocytes of FNMTC patients and sporadic non-medullary thyroid carcinoma (SNMTC) cases, respectively, and gene mutations were screened. In addition, the clinicopathological characteristics, including tumor size, extension of surgery, lymph node metastasis and extra-thyroidal extension, were compared between patients with or without mutations. Read More

    Thyroid cancer after hysterectomy on benign indications: Findings from an observational cohort study in Sweden.
    Int J Cancer 2017 Apr 3;140(8):1796-1801. Epub 2017 Feb 3.
    The Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    To investigate the association between hysterectomy and thyroid cancer subtypes based on histopathology. They did a nationwide, population-based, cohort study from 1973 to 2009 in Sweden. All women above 18 years of age during the period between January 1, 1973 and December 31, 2009 from the Register of Population (n = 5. Read More

    The role of hepatic trans-arterial chemoembolization in metastatic medullary thyroid carcinoma: a specialist center experience and review of the literature.
    Eur J Endocrinol 2017 Apr 18;176(4):461-468. Epub 2017 Jan 18.
    Neuroendocrine Tumor UnitEndocrinology & Metabolism Service, Department of Medicine.
    Background: Liver metastases are relatively common in patients with metastatic medullary thyroid carcinoma (MTC), carrying a negative impact on disease prognosis. The options for selective therapy of liver metastases in MTC patients are limited to catheter-guided procedures such as trans-arterial chemoembolization (TACE). Data regarding the effectiveness and safety of this procedure in MTC are limited. Read More

    Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families.
    Medicine (Baltimore) 2017 Jan;96(3):e5967
    aDepartment of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, PR China bDepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
    Backgroud: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal dominant mutations in RET (rearranged during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma. Little is reported about MEN2A syndrome in the Chinese population.

    Methods: All members of the 3 families along with specific probands of MEN2A were analyzed for their clinical, laboratory, and genetic characteristics. Read More

    Differentiated and Medullary Thyroid Cancer: Surgical Management of Cervical Lymph Nodes.
    Clin Oncol (R Coll Radiol) 2017 Jan 13. Epub 2017 Jan 13.
    Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Thyroid cancer metastasises to the central and lateral compartments of the neck frequently and early. The impact of nodal metastases on outcome is affected by the histological subtype of the primary tumour and the patient's age, as well as the size, number and location of those metastases. The impact of extranodal extension has recently been highlighted as an important prognosticating factor. Read More

    Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls.
    Eur J Med Genet 2017 Mar 9;60(3):178-184. Epub 2017 Jan 9.
    Service de Biochimie « Hormonologie-Métabolisme-Nutrition & Oncologie », Centre de Biologie Pathologie, Centre Hospitalier Régional & Universitaire, F-59037 Lille Cedex, France. Electronic address:
    A heterozygous germline variant in the HABP2 gene c.1601G > A (p.Gly534Glu), which negatively impacts its tumor suppressive activity in vitro, has been described in 4-14% of kindreds of European-American ancestry with familial papillary thyroid carcinoma (fPTC). Read More

    Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation.
    Diagn Pathol 2017 Jan 14;12(1). Epub 2017 Jan 14.
    Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
    Background: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior.

    Case Presentation: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion. Read More

    Anti-tumor effects of shikonin derivatives on human medullary thyroid carcinoma cells.
    Endocr Connect 2017 Feb 9;6(2):53-62. Epub 2017 Jan 9.
    Institute of Pathophysiology and ImmunologyCenter of Molecular Medicine, Medical University of Graz, Graz, Austria
    New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radiotherapy and chemotherapy. We show that the following shikonin derivatives inhibit cell proliferation and cell viability of the MTC cell line TT: acetylshikonin, β,β-dimethylacrylshikonin, shikonin and a petroleum ether extract of the roots of Onosma paniculata containing several shikonin derivatives. The unsubstituted shikonin derivative was found to be the most effective compound with an IC50 of 1. Read More

    Long-term control of hypercortisolism by vandetanib in a medullary thyroid carcinoma with a somatic RET mutation.
    Thyroid 2017 Jan 9. Epub 2017 Jan 9.
    Cochin Institute, Endocrinology, Metabolism, Diabetes, Paris, France.
    Context: Medullary thyroid carcinomas (MTCs) complicated by ectopic Cushing's syndrome have a poor prognosis, partially due to the difficulties to control hypercortisolism by adrenal blocking drugs. Recent reports (including the initial follow-up of this patient) have suggested that tyrosine kinase inhibitors (TKIs) may be a therapeutic option due to an antisecretory action on ACTH. However, there is a lack of long-term follow-up studies. Read More

    A Brief Review on The Molecular Basis of Medullary Thyroid Carcinoma.
    Cell J 2017 26;18(4):485-492. Epub 2016 Sep 26.
    Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Approximately 5-10% of all thyroid cancers are medullary thyroid carcinomas (MTC). MTC is mainly sporadic in nature, but 20-30% of cases are hereditary. Genetic testing for hereditary MTC is very important for the patient and his family, but the patients must be receiving appropriate genetic counseling. Read More

    Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma.
    Ann Diagn Pathol 2017 Feb 30;26:52-56. Epub 2016 Nov 30.
    Department of Otolaryngology - Head and Neck Surgery, Beilinson Campus, Petah Tiqwa, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Medullary thyroid carcinoma management consists mainly of surgical resection and is largely chemoresistant. There is ongoing effort to discover novel therapies for medullary thyroid carcinoma. Increased levels of heat shock proteins have been associated with multiple cancers and are being studied as potential therapeutic targets. Read More

    [Thyroid carcinoma, ten-years file].
    Rozhl Chir 2016 ;95(11):394-397
    Introduction: Even though thyroid carcinoma has, in general, a good prognosis and low mortality rate, its incidence, especially the incidence of early forms of the disease has been growing.

    Method: Retrospective analysis of the file of surgeries of documented thyroid carcinoma within the years of 2006-2015.

    Results: Thyroid carcinoma was recorded in 145 of 1820 patients operated for thyreopathy (8%); microcarcinoma (<10mm) was recorded in 64 cases (44. Read More

    Kidney Involvement in Systemic Calcitonin Amyloidosis Associated With Medullary Thyroid Carcinoma.
    Am J Kidney Dis 2016 Dec 23. Epub 2016 Dec 23.
    Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands.
    A 52-year-old woman with widely disseminated medullary thyroid carcinoma developed nephrotic syndrome and slowly decreasing kidney function. A kidney biopsy was performed to differentiate between malignancy-associated membranous glomerulopathy and tyrosine kinase inhibitor-induced focal segmental glomerulosclerosis. Surprisingly, the biopsy specimen revealed diffuse glomerular deposition of amyloid that was proved to be derived from the calcitonin hormone (Acal), produced by the medullary thyroid carcinoma. Read More

    Genetic and Clinical Features of Medullary Thyroid Carcinoma: The Experience of a Single Center in Costa Rica.
    J Cancer Epidemiol 2016 27;2016:9637173. Epub 2016 Nov 27.
    Division of Endocrinology, Department of Internal Medicine, Hospital Rafael Ángel Calderón Guardia, San José, Costa Rica.
    Background. Activating mutations in the RET gene leads to medullary thyroid carcinoma (MTC). Guidelines encourage performing RET analysis in subjects with hereditary and sporadic disease. Read More

    Anesthetic Management of Clinically Silent Familial Pheochromocytoma with MEN 2A: A Report of Four Cases.
    Indian J Surg 2016 Oct 15;78(5):414-417. Epub 2016 Aug 15.
    Department of Anesthesia, V.M.M.C. and Safdarjung Hospital, A7/14 Mianwali Nagar Paschim Vihar, New Delhi, 110087 India.
    Familial pheochromocytomas are commonly associated with multiple endocrine neoplasia type 2 (MEN 2) syndrome. Majority of the patients present with normal clinical and biochemical parameters in the preoperative period, the incidence of hypertension being only 50 %. Even though patients may be clinically asymptomatic, surveillance and proper preoperative evaluation is important, as surgery for associated tumors may precipitate a hypertensive crisis and result in severe complications. Read More

    PET imaging for thyroid cancers: Current status and future directions.
    Ann Endocrinol (Paris) 2017 Feb 15;78(1):38-42. Epub 2016 Dec 15.
    Centre hospitalo-universitaire de la Timone, Aix-Marseille université, 264, rue Saint-Pierre, 13385 Marseille 05, France.
    Positron emission tomography-computed tomography (PET/CT) combines both functional and anatomic information and provides in vivo molecular information on biological processes that can be useful at different steps of evolution of thyroid cancers. (18)Fluorodeoxyglucose being highly trapped in rapidly dividing cells makes (18)F-FDG-PET recommended in the staging, prognostic evaluation and follow-up of metastatic and/or of poorly differentiated thyroid carcinomas. (18)F-FDG PET/CT can help in the localization of persistent/recurrent disease. Read More

    Most Thyroid Cancers Detected by Sonography Lack Intranodular Vascularity on Color Doppler Imaging: Review of the Literature and Sonographic-Pathologic Correlations for 698 Thyroid Neoplasms.
    J Ultrasound Med 2016 Dec 1. Epub 2016 Dec 1.
    Lenox Hill Radiology, New York, New York, USA.
    Objectives: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation.

    Methods: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. Read More

    [RET pro-oncogene and medullary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Nov;51(11):873-876
    Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
    Medullary thyroid carcinoma (MTC) originats from the parafollicular C cells of the thyroid, which is one of the most aggressive forms of thyroid malignancy with the poor prognosis. Hereditary MTC has multiple endocrine neoplasia types 1, 2A and 2B. The mutation of RET proto-oncogene has been identified as the main cause of MTC, and all mutations locate among the exons 5, 8, 10, 11, 13, 14, 15, and 16. Read More

    Upregulated miR-9-3p promotes cell growth and inhibits apoptosis in medullary thyroid carcinoma by targeting BLCAP.
    Oncol Res 2016 Nov 17. Epub 2016 Nov 17.
    Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
    Medullary thyroid carcinoma (MTC) is one of neuroendocrine cancer derived from parafollicular C cells in thyroid gland.It is great interesting as a research focus because of its unusual genetic, clinical and prognostic characteristics. However, the pathogenesis in MTC is not completely clear. Read More

    Hypervascularity is more frequent in medullary thyroid carcinoma: Compared with papillary thyroid carcinoma.
    Medicine (Baltimore) 2016 Dec;95(49):e5502
    aDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing bDepartment of Ultrasound, Yu Huang Ding Hospital, Yantai, Shandong Province cDepartment of Pathology dDepartment of Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
    This study was designed to retrospectively compare the sonographic features of medullary thyroid carcinoma (MTC) and the features of papillary thyroid carcinoma (PTC).A total of 97 patients with 127 MTCs between January 2000 and January 2016 and 107 consecutive patients with 132 PTCs were included in this study. Two radiologists retrospectively determined the sonographic features and compared the findings of MTCs and PTCs. Read More

    Calcitonin-negative primary neuroendocrine tumor of the thyroid (nonmedullary) in a dog.
    Open Vet J 2016 17;6(3):223-227. Epub 2016 Nov 17.
    Alumna de Programa de Investigación. Fac. de Ciencias Veterinarias, UBA, Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
    The Calcitonin-negative neuroendocrine tumor of the thyroid (CNNET) or "nonmedullary" in humans is a rare tumor that arises primarily in the thyroid gland and may be mistaken for medullary thyroid carcinoma; it is characterized by the immunohistochemical (IHC) expression of neuroendocrine markers and the absence of expression for calcitonin. An Argentine dogo bitch showed a solid, compact thyroid tumor, which was IHC negative for the expression of calcitonin, carcinoembryonic antigen, thyroglobulin and S100 protein, and positive for synaptophysin and cytokeratin AE1-AE3. The Ki-67 proliferation index was low. Read More

    Medullary thyroid carcinoma: a 30-year experience at one institution in Korea.
    Ann Surg Treat Res 2016 Dec 25;91(6):278-287. Epub 2016 Nov 25.
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea.

    Methods: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012.

    Results: In all, 65 patients (76. Read More

    A rare case of medullary carcinoma thyroid metastasizing to bilateral breast parenchyma.
    Nucl Med Rev Cent East Eur 2016 ;19(B):17-19
    Medullary carcinoma of the thyroid (MTC) commonly spreads through the lymphatics to distant sites such as lung, liver and bone. Spread to the breast is rare. We report a case of metastatic MTC which progressed to develop nodal metastases to cer-vical and mediastinal regions, visceral metastases to the liver, lung and ultimately to bilateral breasts. Read More

    Genetic predisposition to endocrine tumors: Diagnosis, surveillance and challenges in care.
    Semin Oncol 2016 Oct 21;43(5):582-590. Epub 2016 Sep 21.
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Health System, Ann Arbor, MI. Electronic address:
    Endocrine tumor syndromes, eg, multiple endocrine neoplasia types 1 and 2, were among the first recognized hereditary predisposition syndromes to tumor development. Over time, the number of endocrine tumor syndromes has significantly expanded, eg, with the recent inclusion of hereditary paraganglioma syndromes. Associations of non-endocrine tumors with hereditary endocrine tumor syndromes and endocrine tumors with non-classical endocrine tumor syndromes have emerged. Read More

    Differential roles of RET isoforms in medullary and papillary thyroid carcinomas.
    Endocr Relat Cancer 2017 Jan 21;24(1):53-69. Epub 2016 Nov 21.
    Division of Cancer Biology and GeneticsCancer Research Institute, Queen's University, Kingston, Ontario, Canada
    The RET receptor tyrosine kinase mediates cell proliferation, survival and migration in embryogenesis and is implicated in the transformation and tumour progression in multiple cancers. RET is frequently mutated and constitutively activated in familial and sporadic thyroid carcinomas. As a result of alternative splicing, RET is expressed as two protein isoforms, RET9 and RET51, which differ in their unique C-terminal amino acids. Read More

    [Study of Medullary Thyroid Carcinoma from a proband].
    Arch Argent Pediatr 2016 Dec;114(6):e421-e424
    Hospital Universitario Miguel Servet, Servicio de Endocrinología Pediátrica, Zaragoza, España.
    Thyroid cancer is an uncommon type of cancer, accounting less than 1% of all cancers in adults, and 0.5-3% of all cancers in children. There are four different types: papillary carcinoma (80-90% of cases), follicular (5-10%), medullary (5%) and anaplastic cell (2-3%). Read More

    All in the family? Analyzing the impact of family history in addition to genotype on medullary thyroid carcinoma aggressiveness in MEN2A patients.
    Fam Cancer 2016 Nov 18. Epub 2016 Nov 18.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.
    Several guidelines for patients with multiple endocrine neoplasia 2A (MEN2A) take into account genotype and family history of medullary thyroid carcinoma (MTC) disease aggressiveness. We sought to determine if an association exists independent of genotype, which could provide important information for counseling MEN2A patients in management of their MTC. Pedigrees of patients with ≥5 family members with MEN2A were retrospectively reviewed. Read More

    Designing and Developing PET-Based Precision Model in Thyroid Carcinoma: The Potential Avenues for a Personalized Clinical Care.
    PET Clin 2017 Jan 23;12(1):27-37. Epub 2016 Sep 23.
    Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Bombay 400 012, India.
    This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG, (68)Ga-DOTA-NOC/TATE, FDOPA). Both are examples of management personalization, where PET-computed tomography (CT) has been found substantially useful in detecting sites of metastatic disease and making decision with regard to feasibility and planning of surgery on an individual patient basis. Read More

    Vandetanib induces a marked anti-tumor effect and amelioration of ectopic Cushing's syndrome in a medullary thyroid carcinoma patient.
    Endocrinol Diabetes Metab Case Rep 2016 24;2016. Epub 2016 Oct 24.
    Department of Medicine , Neuroendocrine Tumor Unit, Endocrinology & Metabolism Service.
    : A 55-year-old woman diagnosed with sporadic MTC underwent total thyroidectomy 20 years ago. After the first surgery, elevated calcitonin levels in parallel with local disease persistence were noted and therefore she underwent repeated neck dissections. During follow-up, multiple foci of metastatic disease were noted in the neck and mediastinal lymph nodes, lungs and bones; however, the disease had an indolent course for a number of years, in parallel with a calcitonin doubling time of more than two years and without significant symptoms. Read More

    Spontaneous proliferative and neoplastic lesions in thyroid and parathyroid glands of nondomestic felids.
    J Vet Diagn Invest 2017 Jan 16;29(1):8-13. Epub 2016 Nov 16.
    Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN.
    Based on microscopic and immunohistochemical characterization, we documented spontaneous proliferative and neoplastic lesions in the thyroid and parathyroid glands of nondomestic felids. Ten animals (4 leopards, 3 tigers, and 3 cougars), all with a previous diagnosis of thyroid neoplasia were identified from the University of Tennessee College of Veterinary Medicine database. The mean age of affected animals was 15. Read More

    A cohort study on 10-year survival of sporadic medullary thyroid carcinoma with somatic RET mutation.
    Kaohsiung J Med Sci 2016 Nov 14;32(11):545-551. Epub 2016 Oct 14.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:
    Somatic rearranged during transfection (RET) mutations are reported in 40-50% of sporadic medullary thyroid carcinoma (sMTC) patients with prognostic significance. As there is a lack of somatic RET mutations reported previously for the Taiwanese population, we tried to assess the presence of somatic RET mutations and evaluate the potential outcome predictors for our sMTC patients. We collected data from seven sMTC patients from the years 1997 to 2005 and analyzed their clinic-pathological features up to 2015. Read More

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