7,302 results match your criteria Thyroid Medullary Carcinoma


Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis.

Endocr Pathol 2019 Apr 17. Epub 2019 Apr 17.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Rue du Bugnon 25, CH-1011, Lausanne, Switzerland.

Medullary thyroid carcinoma (MTC) has been shown to express Prospero homeobox protein 1 (Prox1), a transcription factor whose expression is altered in a variety of human cancers. We conducted a retrospective study on a series of 32 patients with MTC to test the correlation of Prox1 expression in MTC with clinicopathological features and to evaluate its prognostic significance. Correlation of Prox1 immunohistochemical expression with tumor size, proliferative index (Ki67), and calcitonin and CEA serum levels prior to surgery was tested for significant correlations. Read More

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http://link.springer.com/10.1007/s12022-019-9576-5
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http://dx.doi.org/10.1007/s12022-019-9576-5DOI Listing
April 2019
1 Read

Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.

Biomed Res Int 2019 13;2019:9721781. Epub 2019 Mar 13.

Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred more frequently in patients with ectopic ACTH syndrome and in those with a greater than 10-fold elevation of 24-hour urinary free cortisol level. Read More

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http://dx.doi.org/10.1155/2019/9721781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436364PMC

Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma in the Same Patient as a Collision Tumour.

Case Rep Endocrinol 2019 12;2019:4038628. Epub 2019 Mar 12.

Recep Tayyip Erdoğan University School of Medicine, Department of Pathology, Turkey.

Aim: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are two different types of thyroid carcinoma with significant different clinical and histological findings. Their coexistence in the same patient is a very rare event which demands different clinical approach.

Case Report: We report a case with concurrent MTC and PTC in the same thyroid having characteristics of a collision tumour. Read More

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http://dx.doi.org/10.1155/2019/4038628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434312PMC
March 2019
1 Read

[Progression of diagnosis and treatment of medullary thyroid carcinoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):306-310

Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Institute of Cancer Research, Sichuan Cancer Prevention and Control Center, Cancer Hospital affiliate to School of Medicine, Electronic Science and Technology, Chengdu 610041, China.

To review and summarize recent update on preoperative diagnostic criteria, treatment and postoperative follow-up for medullary thyroid carcinoma. The relevant literatures and guidelines about medullary thyroid carcinoma were analyzed and summarized. In the early stages of the disease radical surgery still dominated. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.015DOI Listing
April 2019
2 Reads

Thyroid Incidentaloma on 18F-fluorocholine PET/CT and 68Ga-PSMA PET/CT Revealing a Medullary Thyroid Carcinoma.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Nuclear Medicine, Tenon Hospital, AP-HP, Paris, France.

A 66-year-old man with prostate cancer underwent F-fluorocholine PET/CT and thereafter Ga-labeled prostate-specific membrane antigen PET/CT to explore a rising prostate-specific antigen level. Both PET/CT studies showed a thyroid incidentaloma of the right lobe. Neck ultrasound confirmed the presence of a 16-mm right thyroid nodule. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002559DOI Listing
April 2019
1 Read

TTF-1 positive atypical carcinoid of the epiglottis mimicking medullary thyroid carcinoma.

Nuklearmedizin 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine - Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

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http://dx.doi.org/10.1055/a-0859-7012DOI Listing
April 2019
1 Read

Incidental papillary thyroid microcarcinomas in thyroidectomy specimens: A single-center experience from Turkey.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):211-215

Department of Ear, Nose and Throat, Kayseri City Training and Research Hospital, Kayseri, Turkey.

Background: Papillary thyroid microcarcinoma (PTM) is a relatively common entity in the general population. PTM is often asymptomatic and is detected incidentally during the histopathological examination of thyroidectomy specimens from operations because of benign thyroid disease.

Aims: The aims of the study are to determine the incidence of incidental papillary thyroid microcarcinomas (IPTMs) in our center, to examine the clinicopathologic characteristics of these tumors, and to present our experiences. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_439_18DOI Listing
April 2019
1 Read

The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):206-210

Department of General Surgery, Health Sciences University, Antalya Education and Research Hospital, Antalya 07050, Turkey.

Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior.

Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_202_18DOI Listing
April 2019
2 Reads

Identification of rare variants predisposing to thyroid cancer.

Thyroid 2019 Apr 8. Epub 2019 Apr 8.

The Ohio State University, Human Cancer Genetics Program , 460 W.12th Ave , Columbus, Ohio, United States , 432310 ;

Background: Familial non-medullary thyroid cancer (FNMTC) accounts for a relatively small proportion of thyroid cancer cases, but it displays strong genetic predisposition. So far, only a few of NMTC susceptible genes and low-penetrance variants contributing to NMTC have been described. In this study, we aim to identify rare germline variants that may predispose individuals to non-medullary thyroid carcinoma (NMTC) by sequencing a cohort of 17 NMTC families. Read More

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http://dx.doi.org/10.1089/thy.2018.0736DOI Listing
April 2019
2 Reads
4.493 Impact Factor

Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions.

Case Rep Pathol 2019 10;2019:9890716. Epub 2019 Mar 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. Read More

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http://dx.doi.org/10.1155/2019/9890716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431456PMC
March 2019
2 Reads

Early Calcium Supplementation After Total Thyroidectomy Can Prevent Symptomatic Hypocalcemia - Findings from a Retrospective Study.

Gulf J Oncolog 2019 Jan;1(29):60-65

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kannur, Kerala, India.

Introduction: Thyroidectomy for thyroid cancers and central neck dissection are considered as independent predictors of postoperative hypocalcemia. Post-surgical hypocalcemia is the most common and often the most difficult long-term consequence of thyroid surgeries. Management of hypocalcemia is done with calcium supplementation, but there is no consensus on the timing and the amount of calcium supplementation. Read More

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January 2019
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Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.

BMC Cancer 2019 Apr 5;19(1):325. Epub 2019 Apr 5.

Erasmus MC, Department of Internal Medicine, Academic Center for Thyroid Diseases, European Neuroendocrine Tumor Society center of excellence, P.O Box 2040, 3000, CA, Rotterdam, the Netherlands.

Background: For progressive metastatic medullary thyroid carcinoma (MTC), the available treatment options with tyrosine kinase inhibitors result in grade 3-4 adverse events in a large number of patients. Peptide Receptor Radionuclide Therapy (PRRT), which has also been suggested to be a useful treatment for MTC, is usually well tolerated, but evidence on its effectivity is very limited.

Methods: Retrospective evaluation of treatment effects of PRRT in a highly selected group of MTC patients, with progressive disease or refractory symptoms. Read More

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http://dx.doi.org/10.1186/s12885-019-5540-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451300PMC
April 2019
2 Reads

Identification of a secondary mutation in a pediatric patient with relapsed acute myeloid leukemia leads to the diagnosis and treatment of asymptomatic metastatic medullary thyroid cancer in a parent: a case for sequencing the germline.

Cold Spring Harb Mol Case Stud 2019 Apr 1;5(2). Epub 2019 Apr 1.

Department of Pediatrics, New York, New York 10032, USA.

The incorporation of tumor-normal genomic testing into oncology can identify somatic mutations that inform therapeutic measures but also germline variants associated with unsuspected cancer predisposition. We describe a case in which a variant was identified in a 3-yr-old male with relapsed leukemia. Sanger sequencing revealed the patient's father and three siblings carried the same variant, associated with multiple endocrine neoplasia 2A (MEN2A). Read More

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http://molecularcasestudies.cshlp.org/lookup/doi/10.1101/mcs
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http://dx.doi.org/10.1101/mcs.a003889DOI Listing
April 2019
2 Reads

RET kinase-regulated microRNA-153-3p improves therapeutic efficacy in medullary thyroid carcinoma.

Thyroid 2019 Mar 30. Epub 2019 Mar 30.

University of Sydney, Endocrine Surgical Unit , 202/69 christie st st leonards , Sydney, New South Wales, Australia , 2065 ;

Background: Medullary thyroid carcinoma (MTC) presents a disproportionate number of thyroid cancer deaths due to the lack of an adjuvant treatment beyond surgery. Gain-of-function mutations of the human Rearranged during Transfection (RET) proto-oncogene have been well-established as the key driver of MTC tumorigenesis. RET has been targeted by tyrosine kinase inhibitors (TKIs), such as cabozantinib and vandetanib, however clinical results have been disappointing with regular dose reductions and inevitable progression. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0525
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http://dx.doi.org/10.1089/thy.2018.0525DOI Listing
March 2019
6 Reads

Cure and survival of sporadic medullary thyroid carcinoma following systematic preoperative calcitonin screening.

Langenbecks Arch Surg 2019 Mar 22. Epub 2019 Mar 22.

Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.

Background: The improvement in outcome of sporadic medullary thyroid carcinoma (MTC) during the last decades remains controversial, even if a trend toward a better prognosis has been recently proposed. This study was aimed to determine the time trend cure and survival rates in sporadic MTC according to the use of systematic preoperative calcitonin screening.

Methods: Retrospective analysis of 178 sporadic MTC patients operated between 1980 and 2017 was performed. Read More

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http://dx.doi.org/10.1007/s00423-019-01764-3DOI Listing
March 2019
1 Read

Incidental Finding of Medullary Thyroid Carcinoma Metastasised to Cervical Nodes in a Neck Dissection Specimen

Ir Med J 2019 Feb 14;112(2):877. Epub 2019 Feb 14.

Department of Otorhinolaryngology/Head and Neck surgery, Royal Victoria, Eye and Ear Hospital

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February 2019
2 Reads

Optical biopsy of head and neck cancer using hyperspectral imaging and convolutional neural networks.

J Biomed Opt 2019 Mar;24(3):1-9

University of Texas at Dallas, Department of Bioengineering, Richardson, Texas, United States.

For patients undergoing surgical cancer resection of squamous cell carcinoma (SCCa), cancer-free surgical margins are essential for good prognosis. We developed a method to use hyperspectral imaging (HSI), a noncontact optical imaging modality, and convolutional neural networks (CNNs) to perform an optical biopsy of ex-vivo, surgical gross-tissue specimens, collected from 21 patients undergoing surgical cancer resection. Using a cross-validation paradigm with data from different patients, the CNN can distinguish SCCa from normal aerodigestive tract tissues with an area under the receiver operator curve (AUC) of 0. Read More

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http://dx.doi.org/10.1117/1.JBO.24.3.036007DOI Listing
March 2019
1 Read

Mice conditionally expressing RET(C618F) mutation display C cell hyperplasia and hyperganglionosis of the enteric nervous system.

Genesis 2019 Mar 18:e23292. Epub 2019 Mar 18.

Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Medullary thyroid carcinoma (MTC) develops from hyperplasia of thyroid C cells and represents one of the major causes of thyroid cancer mortality. Mutations in the cysteine-rich domain (CRD) of the RET gene are the most prevalent genetic cause of MTC. The current consensus holds that such cysteine mutations cause ligand-independent dimerization and constitutive activation of RET. Read More

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http://dx.doi.org/10.1002/dvg.23292DOI Listing
March 2019
1 Read

Novel PET tracers: added value for endocrine disorders.

Endocrine 2019 Apr 14;64(1):14-30. Epub 2019 Mar 14.

Sorbonne University, Nuclear Medicine Department, Pitié-Salpêtrière Hospital, 47-83 Bd de l'Hôpital, 75013, Paris, France.

Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides F-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as F-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and F-Choline in the field of primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1007/s12020-019-01895-zDOI Listing
April 2019
2 Reads

Investigating the expression and promoter methylation of RET gene in patients with medullary thyroid cancer with unmutated RET.

J Cell Physiol 2019 Mar 14. Epub 2019 Mar 14.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Thyroid cancer is one of the most common endocrine malignancies. Mutations in the rearranged during transfection (RET) gene, especially in exon 10, 11, and 16, as well as epigenetic modifications, constitute the major underlying molecular events leading to medullary thyroid cancer (MTC). There are few studies on the mutations and epigenetic changes of RET gene in Iranian patients with MTC. Read More

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http://dx.doi.org/10.1002/jcp.28295DOI Listing
March 2019
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Concomitant paraganglioma and thyroid carcinoma: A case report.

World J Clin Cases 2019 Mar;7(5):656-662

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.

Background: Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia (MEN). However, very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid carcinoma. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i5.656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406204PMC
March 2019
1 Read

Molecular imaging for neuroendocrine tumours.

Swiss Med Wkly 2019 02 10;149:w20017. Epub 2019 Mar 10.

Centre for Neuroendocrine and Endocrine Tumours, University Hospital Basel, Basel, Switzerland/ Division of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.

Molecular imaging has found numerous applications in oncology as many tumours express or activate tumour specific target molecules or pathways. This relatively new imaging technique results in a better localisation of tumours and improved tumour staging, especially in the setting of hybrid imaging that is in combination with morphological imaging such as computed tomography. In well differentiated neuroendocrine tumours, somatostatin receptor imaging, as one of the first examples of receptor targeted imaging in humans, plays an important role in the diagnostic work-up of these patients. Read More

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https://doi.emh.ch/smw.2019.20017
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http://dx.doi.org/10.4414/smw.2019.20017DOI Listing
February 2019
4 Reads

Medullary Thyroid Carcinoma: Prognostic Variables And Tumour Markers Affecting Survival.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(Suppl 1)(4):S627-S632

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore.

Background: Medullary thyroid carcinoma (MTC) is a relatively rare thyroid malignancy and its clinical course varies among patients due to its familial association. A number of prognostic factors have been studied, but the significance of these factors remains controversial. We evaluated the progression free survival (PFS) and overall survival (OS) of MTC and its association with tumour marker rising velocity and serum calcitonin (Ct) doubling time (DT). Read More

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March 2019
3 Reads

Multiple endocrine neoplasia type 2A syndrome (MEN2A) and usefulness of 68Ga-DOTATATE PET/CT in this syndrome.

Ann Ital Chir 2019 Mar 4;8. Epub 2019 Mar 4.

Aim: The aim of this study was to evaluate a new imaging method 68Ga-DOTATATE PET/CT as an alternative method to diagnose evidence of neuroendocrine tumors or their metastasis (if any) in patient with MEN 2A.

Methods: Three patients( 2F, 1M; age 28,46 and 50 years) with MEN 2A syndrome who underwent 68Ga-DOTATATE PET/CT scan were prospectively evaluated. PET/CT images were analyzed with measurement of maximum standardized uptake value (SUVmax). Read More

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March 2019
5 Reads
0.683 Impact Factor

Comprehensive evaluation of medullary thyroid carcinoma before surgery.

Chin Med J (Engl) 2019 Apr;132(7):834-841

Department of Ultrasound, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: Medullary thyroid carcinoma (MTC) is a rare disease, but it exhibits more aggressive behaviors. The aim of this study was to improve the diagnostic accuracy of MTC before surgery by analyzing the clinical and ultrasonic data of patients with MTC.

Methods: The study included 71 patients (96 lesions) with histopathologically proven MTC between April 2011 and September 2016 in the Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000160DOI Listing
April 2019
3 Reads

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.

Health Technol Assess 2019 Feb;23(8):1-144

Department of Oncology and Metabolism, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: Medullary thyroid cancer (MTC) is a rare form of cancer that affects patients' health-related quality of life (HRQoL) and survival. Cabozantinib (Cometriq; Ipsen, Paris, France) and vandetanib (Caprelsa; Sanofi Genzyme, Cambridge, MA, USA) are currently the treatment modality of choice for treating unresectable progressive and symptomatic MTC.

Objectives: (1) To evaluate the clinical effectiveness and safety of cabozantinib and vandetanib. Read More

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http://dx.doi.org/10.3310/hta23080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421509PMC
February 2019
1 Read

CT- and ultrasound-characteristics of hepatic lesions in patients with multiple endocrine neoplasia syndrome. A retrospective image review of 25 cases.

PLoS One 2019 28;14(2):e0212865. Epub 2019 Feb 28.

Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Liver metastases from neuroendocrine tumors in multiple endocrine neoplasia syndrome are common (75%) and significantly impairs the prognosis. Characterisation of liver lesions in these patients is challenging, as liver metastases are difficult to differentiate from benign liver lesions such as haemangioma.

Methods: In this study we aimed to characterize the radiological findings of hepatic metastases in MEN patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212865PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394931PMC
February 2019

Trends in Diagnostics, Surgical Treatment, and Prognostic Factors for Outcomes in Medullary Thyroid Carcinoma in Norway: A Nationwide Population-Based Study.

Eur Thyroid J 2019 Jan 8;8(1):31-40. Epub 2018 Nov 8.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Medullary thyroid carcinoma (MTC) is rare. Nationwide population-based studies are important to evaluate its clinical course.

Objectives: To describe all patients with MTC in Norway during 1994-2016 and compare time-related trends in diagnostics and surgical treatment, including prognostic factors for biochemical cure and disease-specific survival (DSS). Read More

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http://dx.doi.org/10.1159/000493977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381913PMC
January 2019
3 Reads

Calcitonin measurement in pediatrics: reference ranges are gender-dependent, validation in medullary thyroid cancer and thyroid diseases.

Clin Chem Lab Med 2019 02 22. Epub 2019 Feb 22.

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital of Leipzig, Leipzig, Germany.

Background: There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). Read More

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http://dx.doi.org/10.1515/cclm-2018-1186DOI Listing
February 2019
4 Reads

The dilemma of metastatic medullary thyroid carcinoma: when to start systemic treatment.

Tumori 2019 Feb 19:300891619829571. Epub 2019 Feb 19.

2 Head and Neck Cancer Medical Oncology 3 Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose:: Two tyrosine kinase inhibitors (TKIs), vandetanib and cabozantinib, have been approved for recurrent/metastatic (R/M) medullary thyroid carcinoma (MTC). To date, it is still debated when and which TKI has to be started in R/M MTC patients. This is due to 1) TKI-related toxicity burden, 2) no overall survival benefit for either TKI, and 3) progression-free survival improvement in MTC subgroups ( RETM918T and RAS mutations) treated with cabozantinib. Read More

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http://dx.doi.org/10.1177/0300891619829571DOI Listing
February 2019
2 Reads

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study.

Endocr Connect 2019 03;8(3):289-298

Hospital de Clínicas de Porto Alegre and Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumors. Several reports have demonstrated that the RET mutation profile may vary according to the geographical area. In this study, we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. Read More

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http://dx.doi.org/10.1530/EC-18-0506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410763PMC
March 2019
1 Read

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Apr 27;29(4):523-529. Epub 2019 Mar 27.

1 Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach, and colorectal cancers, as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate that MSI is absent or at least very rare in the most common and most well studied histologic subtype, papillary thyroid carcinoma. This study aimed to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457885PMC
April 2019
1 Read
4.493 Impact Factor

Clinical translation of theranostic radiopharmaceuticals: Current regulatory status and recent examples.

J Labelled Comp Radiopharm 2019 Feb 11. Epub 2019 Feb 11.

Department of Nuclear Medicine, Medical University Innsbruck, Innsbruck, Austria.

With the development of ever more radiopharmaceuticals suitable for theranostic applications, translation of novel compounds from the preclinical stage towards clinical application becomes a bottleneck for the advances in Nuclear Medicine. This review article summarizes the current regulatory framework for clinical trials with radiopharmaceuticals in the European Union, provides a general overview of the documentation required, and addresses quality, safety, and clinical aspects to be considered. By using a recent successful example of translating a theranostic peptide radioligand, namely In-CP04, which targets receptors expressed in medullary thyroid carcinoma, the pathway from the preclinical development over establishing the required pharmaceutical documentation to designing and submitting a clinical trial is reviewed. Read More

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http://dx.doi.org/10.1002/jlcr.3712DOI Listing
February 2019
4 Reads

[Familial medullary thyroid carcinoma: case report and literature review.]

Rev Fac Cien Med Univ Nac Cordoba 2018 12 12;75(4):303-309. Epub 2018 Dec 12.

Instituto Nacional de Enfermedades Neoplásicas Universidad Nacional Mayor de San Marcos.

Medullary thyroid carcinoma (MTC) is a malignant tumour of the calcitonin-secreting parafollicular C cells of the thyroid gland. Up to 25% of MTC are associated to pathogenic germinal variants on the proto-oncogene RET (locus 10q11.2), which cause Familial Medullary Thyroid Carcinoma (FMTC) or Multiple Endocrine Neoplasia type 2 (MEN2); genetic conditions inherited with autosomal dominant pattern. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n4.20947DOI Listing
December 2018
6 Reads

Compact buds with biphasic differentiation and calcitonin-expressing neuroendocrine cells-previously unrecognized structures of thyroglossal duct unveiled by immunohistochemistry.

Virchows Arch 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Immunophenotype of thyroglossal duct (TGD) cysts, including lining epithelium and thyroid remnants, is scarcely addressed in the literature. There is indirect evidence that C cells may be derived from progenitor cells of the midline thyroid primordium. This is supported by the recent concept of the endodermal origin of lateral thyroid anlagen and several case reports. Read More

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http://dx.doi.org/10.1007/s00428-019-02536-6DOI Listing
February 2019
3 Reads

[A review on the RET proto-oncogene mutation in medullary thyroid carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(22):1754-1758

Medullary thyroid carcinoma(MTC) is a special type of neuroendocrine tumor originated from C-cells of the thyroid gland, MTC can be divided into sporadic(70%-80%)and hereditary(20%-30%), about 98% of the hereditary MTC patients have RET proto-oncogene germline mutation in exon 10, 11, 13, 14, 15, 16. The mutation of RET proto oncogene is closely related to the pathogenesis of MTC, and different mutation of RET proto oncogene exon may lead to different MTC phenotypes.More than 100 kinds of mutations in the RET gene were reported. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.22.018DOI Listing
November 2018
2 Reads

Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer.

Oncotarget 2018 Dec 28;9(102):37662-37675. Epub 2018 Dec 28.

Department of Surgery, The University of Alabama, Birmingham, AL, USA.

Medullary thyroid carcinoma (MTC) is a slow growing neuroendocrine (NE) tumor for which few treatment options are available. Its incidence is rising and mortality rates have remained unchanged for decades. Increasing the repertoire of available treatments is thus crucial to manage MTC progression. Read More

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http://www.oncotarget.com/fulltext/26480
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http://dx.doi.org/10.18632/oncotarget.26480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340867PMC
December 2018
18 Reads

Revisiting the Significance of Prominent C Cells in the Thyroid.

Endocr Pathol 2019 Jan 29. Epub 2019 Jan 29.

Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, NSW, 2065, Australia.

C cell hyperplasia is considered a precursor lesion for hereditary forms of medullary thyroid carcinoma. It has therefore been suggested as a morphological marker to distinguish hereditary from sporadic medullary thyroid carcinoma and to triage genetic testing in resource poor settings. However, numerous definitions for C cell hyperplasia have been suggested, and there is surprisingly little data regarding the number of C cells present in thyroid glands removed for conditions other than medullary carcinoma. Read More

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http://dx.doi.org/10.1007/s12022-019-9567-6DOI Listing
January 2019
2 Reads

Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Population-Based Studies.

Am J Epidemiol 2019 Jan 25. Epub 2019 Jan 25.

Division of Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah.

When recruiting research participants through central cancer registries, high response fractions help ensure population-based representation. Using data from 17 recruitment efforts undertaken by the Utah Cancer Registry from 2007 to 2016, we conducted multivariable mixed effects logistic regression to identify case and study characteristics associated with making contact and obtaining cooperation of Utah cancer cases for the following studies: A Population-Based Childhood Cancer Survivor Cohort Study in Utah, Comparative Effectiveness Analysis of Surgery and Radiation for Prostate Cancer (CEASAR Study), Costs and Benefits of Follow-up Care for Adolescent and Young Adult Cancers, Genetic Analysis of Digestive Cancers, Genetic Epidemiology of Breast Cancer, Genetic Epidemiology of Chronic Lymphocytic Leukemia, Genetic Epidemiology of Multiple Myeloma, Head and Neck Cancer Susceptibility Genes, Impact of Remote Familial Colorectal Cancer Risk Assessment and Counseling (Family CARE Project), Medullary Thyroid Carcinoma (MTC) Surveillance Study Osteosarcoma Surveillance Study, the Prostate Cancer Outcomes Study, Risk Education & Assessment for Cancer Heredity Project (REACH Project), and the Utah Cancer Survivors Study. Characteristics associated with lower odds of contact included Hispanic ethnicity (Odds Ratio [OR] = 0. Read More

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https://academic.oup.com/aje/advance-article/doi/10.1093/aje
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http://dx.doi.org/10.1093/aje/kwz011DOI Listing
January 2019
13 Reads

A novel combined transoral and transcervical surgical approach for recurrent metastatic medullary thyroid cancer to the parapharyngeal space.

J Robot Surg 2019 Jan 28. Epub 2019 Jan 28.

Otolaryngology Head and Neck Surgery Department, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.

Medullary thyroid cancer (MTC) represents less than 1% of all thyroid cancers. Complete surgical resection remains the mainstay of treatment for locoregional disease. Unfortunately, patients with recurrence may present with metastasis to challenging anatomic locations. Read More

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http://dx.doi.org/10.1007/s11701-019-00930-5DOI Listing
January 2019
1 Read

MEN 2B masquerading as chronic blepharitis and euryblepharon.

Orbit 2019 Jan 27:1-5. Epub 2019 Jan 27.

c Ocular Pathology Department , Wills Eye Hospital , Philadelphia , PA , USA.

This is a retrospective case description of a single male patient found to have multiple endocrine neoplasia syndrome type 2B (MEN 2B). At the age of 14, he presented for evaluation of ocular irritation and eyelid thickening. Intraoperative assessment revealed mucosal lesions on the anterior dorsum of his tongue and biopsy of multiple eyelid lesions disclosed bilateral submucosal neuromas, leading to the diagnosis of MEN 2B. Read More

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http://dx.doi.org/10.1080/01676830.2019.1567800DOI Listing
January 2019
5 Reads

Ga-DOTANOC and F-FDG PET/CT in metastatic medullary thyroid carcinoma: novel correlations with tumoral biomarkers.

Endocrine 2019 Jan 25. Epub 2019 Jan 25.

Nuclear Medicine Department, Instituto Português de Oncologia do Porto, Porto, Portugal.

Objective: Metastatic disease is common in medullary thyroid carcinoma (MTC) and it is usually detected by raising calcitonin and carcinoembryonic antigen (CEA) levels. Nuclear medicine imaging has an important role in lesion identification/characterisation. We aim to compare Ga-DOTANOC PET/CT and F-FDG PET/CT performance and to explore the correlations between tumoral markers and functional imaging. Read More

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http://dx.doi.org/10.1007/s12020-019-01846-8DOI Listing
January 2019
1 Read

Medullary Thyroid Carcinoma: Why Is Specialization Mandatory?

Authors:
Theresia Weber

Visc Med 2018 Dec 17;34(6):419-421. Epub 2018 Nov 17.

Department of Endocrine Surgery, Katholisches Klinikum, Mainz, Germany.

Medullary thyroid carcinoma (MTC) represents a distinct form of thyroid cancer with a potentially aggressive behavior, early lymph node metastases, and sporadic as well as hereditary forms. Only surgery with total thyroidectomy and lymph node dissection is able to achieve biochemical cure. Due to the uncommon nature of MTC, a specialization in endocrine surgery for diagnosis as well as therapy of MTC seem to be mandatory for a successful treatment. Read More

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https://www.karger.com/Article/FullText/493809
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http://dx.doi.org/10.1159/000493809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341351PMC
December 2018
8 Reads

Expression profile and biological function of miR-455-5p in colorectal carcinoma.

Oncol Lett 2019 Feb 21;17(2):2131-2140. Epub 2018 Dec 21.

Department of Breast Surgery, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China.

Underexpression of microRNA-455-5p (miR-455-5p) in medullary thyroid carcinoma, melanoma, gastric cancer and additional cancer types has been reported, which may be associated with carcinoma development. The present study aimed to evaluate the expression profile and biological role of miR-455-5p in colorectal carcinoma. Carcinoma tissues and adjacent tissue specimens from 40 patients with colorectal cancer were randomly collected. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9862
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http://dx.doi.org/10.3892/ol.2018.9862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341642PMC
February 2019
12 Reads

Completeness of testing in patients with medullary thyroid carcinoma in Denmark 1997-2013: a nationwide study.

Clin Epidemiol 2019 10;11:93-99. Epub 2019 Jan 10.

Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark,

Background: The completeness of arranged during ransfection () testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the completeness on a population level is unknown. Similarly, it is unknown if the first Danish guidelines from 2002, recommending testing in all MTC patients, improved completeness in Denmark. Read More

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http://dx.doi.org/10.2147/CLEP.S183268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330966PMC
January 2019
2 Reads

Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study.

Lancet Diabetes Endocrinol 2019 Mar 16;7(3):213-220. Epub 2019 Jan 16.

Endocrine Oncology, Institut Gustave Roussy Ecole Doctorale de Cancerologie, Villejuif, France.

Background: Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183033
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http://dx.doi.org/10.1016/S2213-8587(18)30336-XDOI Listing
March 2019
12 Reads

The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma.

BMC Med Imaging 2019 01 18;19(1). Epub 2019 Jan 18.

Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, 200233, China.

Background: The coexistence of primary hyperparathyroidism(PHPT) and papillary thyroid cancer(PTC) is a known entity; it is a rare and complicated setting for diagnostic imaging.

Methods: After reviewing clinical data of 112 patients who had been treated for PHPT in our facility between January 2015 and December 2017, we identified 7 non-medullary thyroid carcinoma (NMTC) (6.25%). Read More

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http://dx.doi.org/10.1186/s12880-019-0306-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339388PMC
January 2019
4 Reads
0.983 Impact Factor

miR-149-5p inhibits cell proliferation and invasion through targeting GIT1 in medullary thyroid carcinoma.

Oncol Lett 2019 Jan 26;17(1):372-378. Epub 2018 Oct 26.

Department of Nuclear Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.

Previous studies indicate that miR-149 could both inhibit and promote the development of human cancer depending on the tumor type. GIT1 was found to play an important role in regulating cell migration. However, the specific function of miR-149-5p and GIT1 in the progression of medullary thyroid carcinoma (MTC) remains unknown. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9628
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http://dx.doi.org/10.3892/ol.2018.9628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313157PMC
January 2019
7 Reads