Search our Database of Scientific Publications and Authors

I’m looking for a

    6822 results match your criteria Thyroid Medullary Carcinoma

    1 OF 137

    Surgical approaches in hereditary endocrine tumors.
    Updates Surg 2017 Apr 28. Epub 2017 Apr 28.
    Minimally Invasive Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
    Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. Read More

    Expression of GLP-1 receptor and CD26 in human thyroid C-cells: The association of thyroid C-cell tumorigenesis with incretin-based medicine.
    Oncol Lett 2017 Apr 20;13(4):2684-2690. Epub 2017 Feb 20.
    Department of Endocrinology, The First Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
    Recent reports have demonstrated that long-term and high dosage treatments with incretin-based medicine, such as hormone glucagon-like peptide-1 (GLP-1) may induce thyroid C-cell pathological changes in rodents, rather than in humans. Doubts regarding the tumorigenic potential of GLP-1 analogues in human thyroid C-cells remain. The present study aimed to determine the expression levels of GLP-1 receptor (GLP-1R) and cluster of differentiation 26 (CD26) in the C-cells of thyroid tissues from non-neoplastic, medullary carcinoma and hyperplasia subjects, and to explore the potential clinical significance. Read More

    Synergistic activity of everolimus and 5-aza-2'-deoxycytidine in medullary thyroid carcinoma cell lines.
    Mol Oncol 2017 Apr 28. Epub 2017 Apr 28.
    Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy.
    Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combination with the mTOR inhibitor everolimus in MTC cells (MZ-CRC-1 and TT). Read More

    Association between Hashimoto's Thyroiditis and Thyroid Cancer in 64,628 Patients.
    Front Oncol 2017 10;7:53. Epub 2017 Apr 10.
    Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Background: The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL). Read More

    [Current situation and thinking of diagnosis and treatment in some types of thyroid cancer].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Apr;52(4):305-308
    Cancer Molecular Diagnosis Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
    As arising incidence of thyroid cancer, the treatment for thyroid carcinoma is becoming increasingly standardized. But there are different opinions on the treatment for some types of thyroid cancers, including the determination of operative opportunity, surgical method, and follow-up observation plan. There are mainly two categories of patients, namely the patients diagnosed as familial thyroid cancer mutation carriers through family screening, including medullary thyroid carcinoma and familial nonmedullary thyroid carcinoma, and the patients with thyroid microcarcinoma that can be observed after diagnosed by fine needle biopsy cytology. Read More

    Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia.
    World J Clin Oncol 2017 Apr;8(2):151-157
    Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Department of Endocrinology, Prince Sultan Military Medical City, Riyadh 11342, Saudi Arabia.
    Aim: To stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system.

    Methods: From January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients (15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. All thyroid cyto-pathological slides and ultra sound reports were reviewed and classified according to the Bethesda System for Reporting Thyroid Cytopathology. Read More

    Incidence and prevalence of multiple endocrine neoplasia 2B in Denmark: a nationwide study.
    Endocr Relat Cancer 2017 Apr 24. Epub 2017 Apr 24.
    C Godballe, Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark.
    Extract: Multiple endocrine neoplasia 2B (MEN2B) is an autosomal dominant inherited cancer syndrome associating medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO), ganglioneuromatosis of the aerodigestive tract and facial, ophthalmologic and skeletal abnormalities. MEN2B is caused by the M918T and A883F mutation of the REarranged during Transfection (RET) proto-oncogene in approximately 95% and <5% of cases, respectively. Only very few other mutations have been reported to cause MEN2B. Read More

    The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population.
    Oncotarget 2017 Apr 6. Epub 2017 Apr 6.
    Oncology Clinic, Holycross Cancer Centre, Kielce, Poland.
    Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p. Read More

    (68)Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with (111)In-octreotide SPECT/CT and conventional imaging.
    Eur J Nucl Med Mol Imaging 2017 Apr 20. Epub 2017 Apr 20.
    Imaging Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo, 05651-901, Brazil.
    Purpose: The aim of this study was to prospectively compare the detection rate of (68)Ga-DOTATATE PET-CT with (111)In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy.

    Methods: Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent (68)Ga-DOTATATE PET-CT, (111)In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard. Read More

    Association of NFκB polymorphisms with clinical outcome of non-medullary thyroid carcinoma.
    Endocr Relat Cancer 2017 Apr 20. Epub 2017 Apr 20.
    C Georgescu, Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, , Cluj-Napoca, Romania
    The NF-κB inflammatory pathway plays a major role in cancer development and clinical progression. Activation of NF-κB signaling is promoted by NFKB1 and inhibited by NFKBIA. The present study aimed to determine the relevance of NFKB1 rs4648068 and NFKBIA rs2233406 genetic variants for non-medullary thyroid cancer (NMTC) susceptibility, progression and clinical outcome. Read More

    Hyalinizing trabecular tumour of the thyroid: fine-needle aspiration cytological diagnosis and correlation with histology.
    J Clin Pathol 2017 Apr 19. Epub 2017 Apr 19.
    Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, Lausanne, Switzerland.
    Hyalinizing trabecular tumour (HTT) is a rare thyroid neoplasm of follicular cell origin characterised by a trabecular growth pattern and prominent intratrabecular and intertrabecular hyalinisation. These peculiar histological features allow the prompt recognition of this neoplasm in surgical specimens. However, cytological diagnosis of HTT remains elusive and misleading because of overlapping characteristics with other thyroid tumours, particularly papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC) and the newly described non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Read More

    Very low expression of PD-L1 in medullary thyroid carcinoma.
    Endocr Relat Cancer 2017 Apr 18. Epub 2017 Apr 18.
    G Sykiotis, Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland
    Monoclonal antibodies that inhibit the interaction between PD1 and PD-L1 are approved for clinical use in several cancer types, and they are also in clinical trials for additional indications, including thyroid carcinomas. A few papers have reported on PD-L1 expression in thyroid carcinomas, including a recent large study by Ahn et al. in Endocrine-Related Cancer using tissue microarrays on differentiated and anaplastic thyroid carcinoma. Read More

    Comparative evaluation of iodine-131 metaiodobenzylguanidine and 18-fluorodeoxyglucose positron emission tomography in assessing neural crest tumors: Will they play a complementary role?
    South Asian J Cancer 2017 Jan-Mar;6(1):31-34
    Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Mumbai, Maharashtra, India.
    Background: 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) has established a role in the evaluation of several malignancies. However, its precise clinical role in the neural crest cell tumors continues to evolve.

    Purpose: The purpose of this study was to compare iodine-131 metaiodobenzylguanidine ((131)I-MIBG) and FDG-PET of head to head in patients with neural crest tumors both qualitatively and semiquantitatively and to determine their clinical utility in disease status evaluation and further management. Read More

    Differential diagnostic significance of HBME-1, CK19 and S100 in various thyroid lesions.
    Malays J Pathol 2017 Apr;39(1):55-67
    Sanjay Gandhi Post-graduate Institute of Medical Sciences, Department of Pathology, C-Block, Rae Bareli Road, Lucknow, Uttar Pradesh, India. Pin 226014.
    Objective: Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions.

    Materials And Methods: Immunohistochemical analysis of 60 thyroidectomy specimens (10 hyperplastic nodules, 14 follicular adenomas and 36 malignant thyroid neoplasms) was carried out. Read More

    Clusterin Expression in Medullary Thyroid Carcinoma is Inversely Correlated with the Presence of Lymph Node Metastases.
    Hum Pathol 2017 Apr 11. Epub 2017 Apr 11.
    Pathology Department, Pitie-Salpetriere Hospital, AP-HP, UPMC, Paris, France.
    Clusterin (CLU) is a sulfated glycoprotein implicated in many physiological and pathological processes, including tumorigenesis. Several studies have reported the overexpression of CLU in human neoplasm, examined by immunohistochemistry. However, there is no extensive data on its role in the thyroid. Read More

    Surgical management of medullary thyroid carcinoma.
    Updates Surg 2017 Apr 13. Epub 2017 Apr 13.
    Section of Endocrine Surgery, Department of Surgery, Duke University School of Medicine, DUMC 2945, Durham, NC, 27710, USA.
    Medullary thyroid cancer (MTC) is a malignant tumor of the parafollicular C cells of the thyroid and comprises only 1-2% of all thyroid cancer cases. Unlike most differentiated thyroid cancer, MTC is associated with a mean survival of 8.6 years and accounts for a disproportionate 8. Read More

    [A Familial Non Medullary Thyroid Carcinoma (FNMTC) : a clinical and genetic update].
    Rev Med Liege 2016 Dec;71(12):557-561
    Service d'Endocrinologie, CHU de Liège, Site du Sart Tilman, Liège, Belgique.
    The syndrome of Familial Non Medullary Thyroid Carcinoma (FNMTC) includes two or more patients with an isolated non-medullary thyroid cancer (papillary, follicular, anaplastic) within the same family. To diagnose FNMTC, the clinician must exclude a syndromic presentation such as the syndromes of Cowden, Gardner or Werner, and the Carney Complex. Up to now, a hundred families with FNMTC have been genetically studied, including forms with (Ch19p13. Read More

    Primary Sarcomas of Thyroid Gland-Series of Three Cases with Brief Review of Spindle Cell Lesions of Thyroid.
    J Clin Diagn Res 2017 Feb 1;11(2):ER01-ER04. Epub 2017 Feb 1.
    Professor, Department of Surgery, Maulana Azad Medical College , Delhi, India .
    Primary Malignant Fibrous Histiocytoma (MFH-T) and Leiomyosarcoma (LMS-T) of the thyroid gland are extremely rare tumors. Very few cases have been reported in the literature. Both entities occur more commonly in women than men. Read More

    Distant metastasis as the sole initial manifestation of well-differentiated thyroid carcinoma.
    Eur Arch Otorhinolaryngol 2017 Apr 5. Epub 2017 Apr 5.
    SingHealth Duke-NUS Head and Neck Centre, Academia, 20 College Road, Singapore, 169856, Singapore.
    Thyroid carcinoma usually presents as a neck lump. Distant metastasis as the sole initial manifestation of well-differentiated thyroid carcinoma (WDTC) is rare and little is known about these patients. The aim of this study is to characterize patients who present with distant metastasis as the sole initial manifestation of WDTC. Read More

    High frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma.
    Pak J Pharm Sci 2016 Nov;29(6(Suppl)):2269-2271
    Pathology Department of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    To study high-frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma (medullary thyroid carcinoma, MTC) with the purpose to improve the diagnostic accuracy of this disease. The clinical data of 20 cases of patients with MTC confirmed by the clinical surgery were retrospectively analyzed. And the high-frequency ultrasound features were analyzed and compared with the pathological characteristics. Read More

    Glycolysis-related protein expression in thyroid cancer.
    Tumour Biol 2017 Mar;39(3):1010428317695922
    Severance Hospital and Department of Pathology, College of Medicine, Yonsei University, Seoul, South Korea.
    We aimed to demonstrate the differences in the expression of glucose metabolism-related proteins according to the thyroid cancer subtypes and investigate the implications of these differences. A total of 566 thyroid cancer patients, including 342 cases of papillary thyroid carcinoma, 112 cases of follicular carcinoma, 70 cases of medullary carcinoma, 23 cases of poorly differentiated carcinoma, 19 cases of anaplastic carcinoma, and 152 cases of follicular adenoma, were enrolled in the study. Immunohistochemical staining for glucose transporter 1, hexokinase II, carbonic anhydrase IX, and monocarbonylate transporter 4 was performed, and the relationship between immunoreactivity and clinicopathologic parameters was analyzed. Read More

    Disseminated Pancreatic Neuroendocrine Neoplasm (NEN) with an Uncommon Localisation in the Central Nervous System. A Case Report.
    Pol J Radiol 2017 1;82:120-125. Epub 2017 Mar 1.
    Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland; Department of Radiology, Clinical University Hospital in Olsztyn, Olsztyn, Poland.
    Background: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1. Read More

    Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
    Adv Anat Pathol 2017 May;24(3):161-168
    *Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR ‡Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal †International Head and Neck Scientific Group, Padua §ENT Service, University of Udine School of Medicine, Udine, Italy ∥Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic ¶Department of Pathology, Radboud University Medical Center, Nijmegen #Department of Pathology, UMC Utrecht, Utrecht, The Netherlands **Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
    The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis and treatment are also different among these tumor types, which necessitates making these distinctions clinically. Read More

    CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.
    Cancer Med 2017 Apr 23;6(4):845-856. Epub 2017 Mar 23.
    Department of Diagnostic Pathology, Kyoto University, Kyoto, Japan.
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1-L) generally play inhibitory roles in cell function by interacting with Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and/or SHP-2. Src family kinases (SFKs) are also known to bind to and phosphorylate CEACAM1-L isoforms. Read More

    Risk profile of the RET A883F germline mutation: an international collaborative study.
    J Clin Endocrinol Metab 2017 Mar 17. Epub 2017 Mar 17.
    Endocrine Practice, Moleculargenetic Laboratory, Brückenstr 21, 69120 Heidelberg, Germany.
    Context: The A883F germline mutation of the REarranged during Transfection proto-oncogene causes multiple endocrine neoplasia 2B. In the revised American Thyroid Association (ATA) guidelines for the management of medullary thyroid carcinoma (MTC) the A883F mutation has been reclassified from the highest to high risk level, although no well-defined risk profile for this mutation exists.

    Objective: To create a risk profile for the A883F mutation for appropriate classification in the ATA risk levels. Read More

    Epigenetic regulation of RET receptor tyrosine kinase and non-coding RNAs in MTC.
    Mol Cell Endocrinol 2017 Mar 15. Epub 2017 Mar 15.
    Cancer Genetics Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, St Leonards, NSW, Australia; Sydney Medical School Northern, Royal North Shore Hospital, The University of Sydney, St Leonards, Sydney, NSW, Australia; University of Sydney Endocrine Surgery Unit, Royal North Shore Hospital, St Leonards, NSW, Australia. Electronic address:
    Medullary thyroid carcinoma (MTC) is an aggressive and rare cancer with limited treatment options for metastatic disease. Due to this, there is a need for a better understanding of MTC biology in the hope of improved treatments. One area of improved understanding of cancer biology is epigenetics. Read More

    Thyroid Cancer in the Pediatric Age in Sicily: Influence of the Volcanic Environment.
    Anticancer Res 2017 03;37(3):1515-1522
    Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
    Background/aim: Pediatric thyroid cancer (TC) is rare but its incidence is increasing. We analyzed incidence and characteristics of pediatric TC in Sicily and comparatively evaluated data from the volcanic and non-volcanic areas.

    Materials And Methods: All incident pediatric (0-19 years) TCs in Sicily between 2002-2009 were analyzed for the area of residence and compared to data for adults. Read More

    A multicenter phase II study of sunitinib in patients with locally advanced or metastatic differentiated, anaplastic or medullary thyroid carcinomas: mature data from the THYSU study.
    Eur J Cancer 2017 May 20;76:110-117. Epub 2017 Mar 20.
    Department of Medical Oncology, Institut Claudius Régaud, IUCT, Toulouse, France.
    Purpose: Patients with advanced radioactive iodine resistant differentiated (MDTC) or medullary (MMTC) thyroid cancer had an unmet need. Early data showed promising efficacy of vascular endothelial growth factor receptor inhibitors. We investigated sunitinib in this setting. Read More

    Assessment of Depression, Anxiety, Quality of Life, and Coping in Long-Standing Multiple Endocrine Neoplasia Type 2 Patients.
    Thyroid 2017 Apr 4. Epub 2017 Apr 4.
    1 Endocrine Genetics Unit (LIM-25), Endocrinology Division, Hospital das Clínicas, University of São Paulo School of Medicine , São Paulo, Brazil .
    Background: Data on psychological harm in multiple endocrine neoplasia type 2 (MEN2) are scarce.

    Objectives: The aim of this study was to assess anxiety, depression, quality of life, and coping in long-standing MEN2 patients.

    Patients And Methods: Patients were 43 adults (age ≥18 years) with clinical and genetic diagnosis of MEN2 and long-term follow-up (10. Read More

    Expression of Autophagy-Related Proteins in Different Types of Thyroid Cancer.
    Int J Mol Sci 2017 Mar 2;18(3). Epub 2017 Mar 2.
    Department of Pathology, Yonsei University College of Medicine, Seoul 130-701, Korea.
    Thyroid cancer is common type of malignant tumor in humans, and the autophagy status of such tumors may vary according to subtype. This study aimed to investigate the expression and implications of the major autophagy-related molecules light chain (LC) 3A, LC3B, p62, and BNIP-3 in human thyroid carcinoma. Tissue microarrays were constructed from 555 thyroid cancers (papillary thyroid carcinoma (PTC): 342; follicular carcinoma (FC): 112; medullary carcinoma (MC): 70; poorly differentiated carcinoma (PDC): 23; and anaplastic carcinoma (AC): 8) and 152 follicular adenomas (FAs). Read More

    Rare Thyroid Malignancies: an Overview for the Oncologist.
    Clin Oncol (R Coll Radiol) 2017 May 24;29(5):298-306. Epub 2017 Feb 24.
    Department of Head and Neck Surgery, Otolaryngology and Facial Plastic Surgery Associates, Dallas-Fort Worth, TX, USA. Electronic address:
    Anaplastic thyroid cancer, medullary thyroid cancer, primary thyroid lymphoma and primary thyroid sarcoma are rare thyroid cancers that comprise 5-10% of all thyroid malignancies. Unlike well-differentiated thyroid cancers, these malignancies have few treatment options and carry a worse prognosis. The literature surrounding these pathologies is limited, but remains an area of active research. Read More

    Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.
    Sci Rep 2017 Feb 23;7:43396. Epub 2017 Feb 23.
    State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Tianjin Key Laboratory of Protein Sciences and College of Life Sciences, Nankai University, Tianjin 300071, China.
    Thyroid is a one of the most important endocrine organs. Understanding the molecular mechanism underlying thyroid development and function, as well as thyroid diseases, is beneficial for the clinical treatment of thyroid diseases and tumors. Through genetic linkage analysis and exome sequencing, we previously identified an uncharacterized gene C14orf93 (RTFC, mouse homolog: 4931414P19Rik) as a novel susceptibility gene for familial non-medullary thyroid carcinoma, and demonstrated its function in promoting thyroid tumor. Read More

    Is fine needle aspiration really not necessary in patients with thyroid nodules ≤ 1 cm with highly suspicious features on ultrasonography and candidates for active surveillance?
    Diagn Cytopathol 2017 Apr 20;45(4):294-296. Epub 2017 Feb 20.
    Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    Background: The low rate of progression associated with the potential complications of thyroidectomy makes active surveillance an increasingly recommended management in low-risk papillary microcarcinomas of the thyroid (PMT). The objective of this study was to report the results of fine needle aspiration (FNA) of nodules ≤ 1 cm with highly suspicious appearance on ultrasonography (US) in patients who are potential candidates for active surveillance.

    Methods: We revised thyroid nodules ≤ 1 cm with highly suspicious appearance on US in patients without known distant metastases, suspicion of extrathyroid extension, or suspicious lymph nodes on US. Read More

    Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.
    Oncologist 2017 Mar 16;22(3):255-263. Epub 2017 Feb 16.
    Foundation Medicine, Cambridge, Massachusetts, USA.
    Background: Thyroid carcinoma, which is rare in pediatric patients (age 0-18 years) but more common in adolescent and young adult (AYA) patients (age 15-39 years), carries the potential for morbidity and mortality.

    Methods: Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements. This PAYA data series includes 41 patients with papillary thyroid carcinoma (PTC), 3 with anaplastic thyroid carcinoma (ATC), and 14 with medullary thyroid carcinoma (MTC). Read More

    Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral RET Wild-Type Neoplasm with Revision of the Literature.
    Rare Tumors 2016 Nov 20;8(4):6537. Epub 2016 Dec 20.
    Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
    Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. Read More

    [Clinical features and mutations of RET proto-oncogene in a pedigree affected with type 2A multiple endocrine neoplasia].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Feb;34(1):106-109
    Department of Endocrinology and Metabolism, Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, China.
    Objective: To investigate the clinical features and mutations of RET proto-oncogene in a pedigree affected with multiple endocrine neoplasia type 2A (MEN2A).

    Methods: Clinical data of the family members was collected. Genomic DNA from peripheral blood leukocytes were extracted and subjected to PCR amplification. Read More

    High frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma.
    Pak J Pharm Sci 2016 Nov;29(6(Suppl)):2269-2271
    Pathology Department of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    To study high-frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma (medullary thyroid carcinoma, MTC) with the purpose to improve the diagnostic accuracy of this disease. The clinical data of 20 cases of patients with MTC confirmed by the clinical surgery were retrospectively analyzed. And the high-frequency ultrasound features were analyzed and compared with the pathological characteristics. Read More

    Basal Serum Calcitonin, After Calcium Stimulation, and in the Needle Washout of Patients with Thyroid Nodules and Mild or Moderate Basal Hypercalcitoninemia.
    Horm Metab Res 2017 Feb 6;49(2):129-134. Epub 2017 Feb 6.
    Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
    This prospective study evaluated the concentrations of basal serum calcitonin (Ctn), Ctn after stimulation with calcium, and Ctn in the needle washout (FNA-Ctn) as predictors of sporadic medullary thyroid carcinoma (MTC) in patients with thyroid nodules and basal Ctn between 10 and 100 pg/ml. Forty-one patients were included in the study. MTC was diagnosed in only 6 patients (14. Read More

    Search of the p.M918T Mutation in the RET Oncogene in Mexican Adult Patients with Medullary Thyroid Carcinoma.
    Exp Clin Endocrinol Diabetes 2017 Apr 6;125(4):218-222. Epub 2017 Feb 6.
    Head and Neck Cancer Deparment, National Cancer Institute, Mexico City.
    Inherited mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, predispose individuals to the multiple endocrine neoplasia type 2 (MEN 2) cancer syndromes. The major component tumor of these syndromes is medullary thyroid carcinoma (MTC). To date, somatic mutations in RET have been identified in tumors from individuals with MEN 2 finding. Read More

    Hepatic Lesions in a Cirrhotic Liver: Primary or Metastases?
    J Nucl Med Technol 2017 03 2;45(1):50-52. Epub 2017 Feb 2.
    Department of Radiology, University of Washington, Seattle, Washington
    Although prior studies showed that patients with cirrhosis have a lower risk of developing liver metastases, appropriate workup of incidental liver masses in cirrhotic liver is important for a correct diagnosis. Here we present a case of newly diagnosed liver cirrhosis with multifocal hepatic lesions, which was initially categorized as a LI-RADS (Liver Imaging Reporting and Data System) 5 lesions. Scintigraphy with (111)In-pentetreotide (Octreoscan) indicated a suspected thyroid nodule, later confirmed to represent medullary thyroid carcinoma lesion. Read More

    Multiple Endocrine Neoplasia Type 2B Unmasked by 18 F-FDG PET/CT and 131 I-MIBG SPECT/CT.
    Clin Nucl Med 2017 Apr;42(4):297-299
    From the Department of Nuclear Medicine, and Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
    F-FDG PET/CT was performed to detect an occult malignancy in a 26-year-old woman with complicated medical history which included paroxysmal hypertension and significantly elevated tumor marker. The images revealed lesions in the thyroid, lymph nodes, and bilateral adrenal glands. Further I-MIBG SPECT/CT revealed intense activity in the lesion in the left adrenal gland, which was consistent with pheochromocytoma. Read More

    Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib.
    Pharmacol Res 2017 May 25;119:89-98. Epub 2017 Jan 25.
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences,St. John's University, Queens, New York, 11439, USA. Electronic address:
    Cabozantinib (XL184) is a small molecule tyrosine kinase receptor inhibitor, which targets c-Met and VEGFR2. Cabozantinib has been approved by the Food and Drug Administration to treat advanced medullary thyroid cancer and renal cell carcinoma. In the present study, we evaluated the ability of cabozantinib to modulate the function of the ATP-binding cassette subfamily G member 2 (ABCG2) by sensitizing cells that are resistant to ABCG2 substrate antineoplastic drugs. Read More

    Gene Signature Associated with Upregulation of the Wnt/β-Catenin Signaling Pathway Predicts Tumor Response to Transarterial Embolization.
    J Vasc Interv Radiol 2017 Mar 24;28(3):349-355.e1. Epub 2017 Jan 24.
    Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, Howard-118, 1275 York Ave., New York, NY10065.
    Purpose: To identify gene mutations in tumors undergoing transarterial embolization and explore the relationship between gene mutations and tumor response to embolization.

    Materials And Methods: This was a retrospective review that included 17 patients with primary or metastatic liver tumors treated with embolization and had specimens analyzed for a 341-gene panel next-generation sequence assay. Pathologic conditions included hepatocellular, carcinoid, pancreatic neuroendocrine, melanoma, medullary thyroid, and liver acinar-cell carcinoma. Read More

    Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.
    Oncoimmunology 2016 9;5(12):e1229725. Epub 2016 Sep 9.
    Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center , Nijmegen, the Netherlands.
    Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment in non-medullary thyroid cancer (TC), the most common endocrine malignancy. However, little is known regarding the regulation of their function in TC. Transcriptome analysis in a model of TC-induced macrophages identified increased inflammatory characteristics and rewiring of cell metabolism as key functional changes. Read More

    MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit.
    Mol Cancer 2017 Jan 26;16(1):24. Epub 2017 Jan 26.
    Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Schillingallee 69, 18057, Rostock, Germany.
    Background: Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN) type 2A and 2B. These tumors are highly aggressive with a high propensity for early metastasis and chemoresistance. This attribute makes this neoplasia an excellent model for probing mechanisms underlying cancer progression. Read More

    Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma.
    J Biol Chem 2017 Mar 24;292(9):3888-3899. Epub 2017 Jan 24.
    the Cardiovascular Research Institute, University of California, San Francisco, California 94158
    Among the four different types of thyroid cancer, treatment of medullary thyroid carcinoma poses a major challenge because of its propensity of early metastasis. To further investigate the molecular mechanisms of medullary thyroid carcinoma and discover candidates for targeted therapies, we developed a new mouse model of medullary thyroid carcinoma based on our CGRP(CreER) mouse line. This system enables gene manipulation in parafollicular C cells in the thyroid, the purported cells of origin of medullary thyroid carcinoma. Read More

    [Next generation sequencing technology for susceptible gene screening in familial non-medullary thyroid carcinoma].
    Zhonghua Zhong Liu Za Zhi 2017 Jan;39(1):24-28
    Department of Thyroid and Neck Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
    Objective: To screen genes related to familial non-medullary thyroid carcinoma (FNMTC) using next-generation sequencing (NGS). Methods: A panel of NGS was designed and sequencing was performed for DNA samples extracted from peripheral blood leukocytes of FNMTC patients and sporadic non-medullary thyroid carcinoma (SNMTC) cases, respectively, and gene mutations were screened. In addition, the clinicopathological characteristics, including tumor size, extension of surgery, lymph node metastasis and extra-thyroidal extension, were compared between patients with or without mutations. Read More

    Thyroid cancer after hysterectomy on benign indications: Findings from an observational cohort study in Sweden.
    Int J Cancer 2017 Apr 3;140(8):1796-1801. Epub 2017 Feb 3.
    The Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    To investigate the association between hysterectomy and thyroid cancer subtypes based on histopathology. They did a nationwide, population-based, cohort study from 1973 to 2009 in Sweden. All women above 18 years of age during the period between January 1, 1973 and December 31, 2009 from the Register of Population (n = 5. Read More

    1 OF 137