3,826 results match your criteria Thyroid Lymphoma


Secondary thyroid malignancy from metastatic colon lymphoma.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Unidad de Endocrinología y Nutrición, Consorci Hospital General Universitari de València, Valencia, Comunitat Valenciana, Spain.

Primary thyroid malignancy is more frequent than secondary. This case report describes a colon lymphoma with unique thyroid metastasis. When a thyroid lesion appears in an extension study such as Positron emission tomography-computed tomography marked with 18F-2-fluoro-2-deoxy-D-glucose, it is recommended to perform an ultrasound. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22859
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http://dx.doi.org/10.1136/bcr-2018-228591DOI Listing
March 2019
1 Read

Combination treatment with BRAFV600E inhibitor, vemurafenib, and BH3 mimetic, navitoclax, for BRAF mutant thyroid carcinoma.

Thyroid 2019 Mar 14. Epub 2019 Mar 14.

School of Medicine, Kyungpook National University, Department of Nuclear Medicine, Daegu, Korea (the Republic of).

Background Vemurafenib is a selective BRAF inhibitor (BRAFi) that has shown promising activity in BRAFV600E-positive papillary thyroid cancer (PTC). However, adverse events and resistance to a single-agent BRAFi often require discontinuation of the targeted therapy in BRAFV600E-positive PTC. Thus, we investigated the expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) family members, which is frequently overexpressed in many human cancers to inhibit apoptosis, in PTC harboring the BRAFV600E mutation after BRAFi treatment and then evaluated the cytotoxic effects of a homology 3 domain (BH3)-mimetic in combination with a BRAFi. Read More

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http://dx.doi.org/10.1089/thy.2018.0511DOI Listing

ZFP91 zinc finger protein expression pattern in normal tissues and cancers.

Oncol Lett 2019 Mar 23;17(3):3599-3606. Epub 2019 Jan 23.

Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland.

Zinc finger protein 91 (ZFP91) gene has been recently acknowledged to possess oncogenic properties. To date, its expression has been examined only in a handful of human organs and cancer types. The aim of the present study was to characterize, for the first time, the ZFP91 expression pattern in a range of human tissues and cancer types. Read More

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http://dx.doi.org/10.3892/ol.2019.9963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396258PMC

Sex ratio among childhood cancers by single year of age.

Pediatr Blood Cancer 2019 Feb 28:e27620. Epub 2019 Feb 28.

Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

Background: The male excess in childhood cancer incidence is well-established; however, the underlying biologic mechanisms remain unknown. Examining the association between male sex and childhood cancer by single year of age and tumor type may highlight important periods of risk such as variation in growth and hormonal changes, which will inform etiologic hypotheses.

Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) 18 registries (2000-2015), incidence rate ratios (IRR) and 95% confidence intervals (95% CI) were estimated as the measure of association between male sex and childhood cancer by single year of age (0-19). Read More

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http://dx.doi.org/10.1002/pbc.27620DOI Listing
February 2019
1 Read

Non-genomic Actions of Thyroid Hormones Regulate the Growth and Angiogenesis of T Cell Lymphomas.

Front Endocrinol (Lausanne) 2019 13;10:63. Epub 2019 Feb 13.

Instituto de Investigaciones Biomédicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina.

T-cell lymphomas (TCL) are a heterogeneous group of aggressive clinical lymphoproliferative disorders with considerable clinical, morphological, immunophenotypic, and genetic variation, including ~10-15% of all lymphoid neoplasms. Several evidences indicate an important role of the non-neoplastic microenvironment in promoting both tumor growth and dissemination in T cell malignancies. Thus, dysregulation of integrin expression and activity is associated with TCL survival and proliferation. Read More

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http://dx.doi.org/10.3389/fendo.2019.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381017PMC
February 2019
2 Reads

[Szpiczak plazmocytowy tarczycy - opis przypadku].

Pol Merkur Lekarski 2019 Jan;46(271):42-44

Students' Scientific Group at 1st Department and Clinic of General, Gastroenterological and Endocrine Surgery.

Extramedullary plasmacytoma (EMP) is the localized plasma cell neoplasm, that arise in tissues other than bone. The upper respiratory tract and the oral cavity are the most common sites for EMP location. EMPs of the thyroid gland are extremely rare and thus little is known about their behavior compared to other EMPs. Read More

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January 2019
1 Read

Diagnostic Value of FDG PET-CT Quantitative Parameters and Deauville-Like 5 Point-Scale in Predicting Malignancy of Focal Thyroid Incidentaloma.

Front Med (Lausanne) 2019 12;6:24. Epub 2019 Feb 12.

EA GETBO 3878, University Hospital of Brest, Brest, France.

To evaluate the diagnostic value of FDG PET-CT metabolic parameters and Deauville-like 5 point-scale to predict malignancy in a population of patients presenting focal thyroid incidentaloma (fTI). This retrospective study included 41 fTI, classified according to cytological and histological data as benign (BL) or malignant lesion (ML). FDG PET-CT semi-quantitative parameters (SUVmax, SUVmean, SUVpeak, MTV, TLG), tumor to liver SUVmean ratio (TLRmax and TLRmean), tumor to blood-pool SUVmean ratio (TBRmax and TBRmean) were calculated. Read More

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http://dx.doi.org/10.3389/fmed.2019.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379284PMC
February 2019
1 Read

Thyroid dysfunction induced by nivolumab: searching for disease patterns and outcomes.

Endocrine 2019 Feb 25. Epub 2019 Feb 25.

Department of Endocrinology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Purpose: Nivolumab is a monoclonal antibody that blocks the activation of programmed death-1 receptor, promoting T-cell activation against cancer cells. Thyroid dysfunction (TD) is a common immune-related adverse event (irAE) induced by nivolumab. We report the prevalence, patterns and outcomes of nivolumab-induced TD among cancer patients in our center. Read More

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http://link.springer.com/10.1007/s12020-019-01871-7
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http://dx.doi.org/10.1007/s12020-019-01871-7DOI Listing
February 2019
3 Reads

Genetic and immunohistochemical analyses of ciliated muconodular papillary tumors of the lung: A report of five cases.

SAGE Open Med Case Rep 2019 15;7:2050313X19830483. Epub 2019 Feb 15.

Department of Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.

Ciliated muconodular papillary tumors are benign lesions located in the peripheral lung field. Recent studies revealed and epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase gene rearrangement. Five ciliated muconodular papillary tumors were screened for the V600E and mutations via polymerase chain reaction. Read More

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http://dx.doi.org/10.1177/2050313X19830483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378433PMC
February 2019
1 Read

Risk of subsequent primary neoplasms in survivors of adolescent and young adult cancer (Teenage and Young Adult Cancer Survivor Study): a population-based, cohort study.

Lancet Oncol 2019 Feb 20. Epub 2019 Feb 20.

Centre for Childhood Cancer Survivor Studies, Institute of Applied Health Research, University of Birmingham, Birmingham, UK. Electronic address:

Background: Few studies have investigated the risks of subsequent primary neoplasms after adolescent and young adult (AYA) cancer. We investigated the risks of specific subsequent primary neoplasms after each of 16 types of AYA cancer.

Methods: The Teenage and Young Adult Cancer Survivor Study is a population-based cohort of 200 945 survivors of cancer diagnosed when aged 15-39 years in England and Wales from Jan 1, 1971, to Dec 31, 2006. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30903-3DOI Listing
February 2019
1 Read

Clinical management of localized undifferentiated sinonasal carcinoma: our experience and review of the literature.

Anticancer Drugs 2019 Mar;30(3):308-312

Departments of Head and Neck and Sarcoma Oncology.

Undifferentiated sinonasal carcinoma (SNUC) is defined as a small round blue cell tumor that is immunohistochemically distinct from other sinonasal malignancies, such as lymphoma, mucosal melanoma, nasopharyngeal carcinoma, neuroendocrine carcinoma, and olfactory neuroblastoma. SNUCs are very aggressive malignancies, provoking quick destruction of the splanchnocranium structures. Being a very rare neoplasm, there are no prospective clinical trials assessing their treatment strategies, so lots of data are derived by small retrospective trials. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000707DOI Listing
March 2019
1 Read

Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults.

Br J Cancer 2019 Feb 19. Epub 2019 Feb 19.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: The present study examined whether adult height was associated with all site-combined or site-specific cancers.

Methods: We used a nationwide claim data of 22,809,722 Korean participants including both men and women (2009-2012). The deciles of height from different age and sex groups were merged into a new quintile. Read More

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http://dx.doi.org/10.1038/s41416-018-0371-8DOI Listing
February 2019
3 Reads
4.836 Impact Factor

[A retrospective analysis of 12 cases of primary thyroid lymphoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):165-170

Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.

Objective: To discuss the clinical characteristics and diagnostic and therapeutic considerations of primary thyroid lymphoma (PTL) by reviewing PTL cases.

Methods: In the study, 12 cases of PTL diagnosed and treated in Peking University First Hospital between January 1995 and September 2015 were identified. The clinical characteristics, management experiences and prognosis of these cases were reviewed retrospectively. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.028DOI Listing
February 2019
1 Read

How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

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http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

Comorbidities (excluding lymphoma) in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

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http://dx.doi.org/10.1093/rheumatology/key329DOI Listing
February 2019
3 Reads

When a Goitre is a Thyroid Lymphoma.

Eur J Case Rep Intern Med 2018 27;5(12):000999. Epub 2018 Dec 27.

Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Portugal.

Primary thyroid lymphoma is a rare cause of both thyroid malignancy and extra-nodal lymphoma. It typically presents as a rapidly enlarging goitre with compressive symptoms. Histological analysis of a biopsy specimen is necessary to confirm the diagnosis. Read More

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http://dx.doi.org/10.12890/2018_000999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346969PMC
December 2018
4 Reads

A Rare Case of Bilateral Proptosis.

Eur J Case Rep Intern Med 2018 28;5(11):000966. Epub 2018 Nov 28.

Medicine IV Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.

A 65-year-old man presented with a 2-year history of severe bilateral proptosis, palpable lymphadenopathy and moderate hepatosplenomegaly. A blood test was positive for hepatitis C infection. CT showed palpebral infiltrative lesions with regional progression through the temporal and masticatory spaces to the pharynx and hypopharynx causing almost complete airway obstruction. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/966
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http://dx.doi.org/10.12890/2018_000966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346810PMC
November 2018
5 Reads

Anaplastic Lymphoma Kinase (ALK)-positive Tumors: Clinical, Radiographic and Molecular Profiles, and Uncommon Sites of Metastases in Patients With Lung Adenocarcinoma.

Am J Clin Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, CA.

Introduction: Anaplastic lymphoma kinase (ALK) gene rearrangements are observed in about 4% to 8% non-small cell lung cancer (NSCLC). ALK+ tumors have been associated with increased pleural and pericardial disease. Our primary objective was to determine the uncommon sites of metastasis of ALK+ NSCLC. Read More

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http://dx.doi.org/10.1097/COC.0000000000000508DOI Listing
February 2019
1 Read

Probability of carcinogenesis due to involved field and involved site radiation therapy techniques for supra- and infradiaphragmatic Hodgkin's disease.

Phys Med 2019 Jan 3;57:100-106. Epub 2019 Jan 3.

Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete, Greece.

Purpose: To estimate the second cancer risk associated with Hodgkin Lymphoma (HL) radiotherapy at supradiaphragmatic or infradiaphragmatic region, using the involved field (IFRT) and the involved site radiotherapy (ISRT).

Materials And Methods: IFRT and ISRT treatment plans were created for twenty HL patients. Three dimensional plans (3DRT) were employed for all patients. Read More

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http://dx.doi.org/10.1016/j.ejmp.2018.12.036DOI Listing
January 2019
1 Read

MiR-618 Suppresses Metastasis in Gastric Cancer by Downregulating the Expression of TGF-β2.

Anat Rec (Hoboken) 2019 Feb 8. Epub 2019 Feb 8.

Department of Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Recent studies have demonstrated that microRNAs regulate gene expression and are related to cancer progression. Increasing evidence shows that miR-618 plays an important role in a variety of tumors, including thyroid carcinomas, breast cancer and lymphoma cancer. However, no studies have examined the expression or function of miR-618 in gastric cancer (GC). Read More

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http://doi.wiley.com/10.1002/ar.24083
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http://dx.doi.org/10.1002/ar.24083DOI Listing
February 2019
6 Reads

Cancer incidence and mortality among firefighters.

Int J Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of Research, Cancer Registry of Norway - Institute of Population-Based Cancer Research, Oslo, Norway.

Firefighters are exposed to both known and suspected carcinogens. This study aims to systematically review the literature on the association of firefighting occupation and cancer incidence and mortality, overall and for specific cancer sites. A systematic review using PubMed, Embase, and Web of Science was performed up to January 1, 2018. Read More

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http://dx.doi.org/10.1002/ijc.32199DOI Listing
February 2019
4 Reads

Differential expression of estrogen receptor-α on follicular dendritic cells from patients with grade 1-2 and grade 3 follicular lymphoma.

Hematol Oncol 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.

Hormone therapy has been used for patients with estrogen receptor alpha (ERα)-positive breast cancers. Recently, some studies reported the expression of ERα on neoplastic cells from B cell lymphomas. However, there has been only one report of ERα expression on the follicular dendritic cells (FDCs) that structurally and functionally support the microenvironment of follicular lymphomas (FLs). Read More

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http://dx.doi.org/10.1002/hon.2577DOI Listing
February 2019
1 Read

Systemic lupus erythematosus is a risk factor for cancer: a nationwide population-based study in Korea.

Lupus 2019 Mar 2;28(3):317-323. Epub 2019 Feb 2.

1 Department of Internal Medicine, Chonnam National University Medical School, Gwangju.

Objective: Specific differences in cancer risk have been observed between systemic lupus erythematosus patients and the general population. Although meta-analyses have estimated cancer incidence in systemic lupus erythematosus patients, results have been inconclusive. Hence, we aimed to assess malignancy risk in systemic lupus erythematosus patients, compared to the risk in the general population. Read More

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http://dx.doi.org/10.1177/0961203319826672DOI Listing
March 2019
2 Reads

Lasting effects of cancer and its treatment on employment and finances in adolescent and young adult cancer survivors.

Cancer 2019 Feb 1. Epub 2019 Feb 1.

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Background: The impact of cancer and its treatment on employment and financial burden in adolescents/young adults (AYAs) is not fully known.

Methods: Eligibility for this cross-sectional study of AYA cancer survivors included the diagnosis of a malignancy between ages 18 and 39 years and survey completion within 1 to 5 years from diagnosis and ≥1 year after therapy completion. Participants were selected randomly from the tumor registries of 7 participating sites and completed an online patient-reported outcomes survey to assess employment and financial concerns. Read More

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http://dx.doi.org/10.1002/cncr.31985DOI Listing
February 2019
3 Reads

microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor β1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor.

J Cell Biochem 2019 Jan 31. Epub 2019 Jan 31.

Department of Otolaryngology - Head and Neck Surgery, The Second Hospital of Jilin University, Changchun, P. R. China.

Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with growing incidence every year. microRNAs (miRs) are known to regulate the physiological and pathological processes of cancers, such as proliferation, migration, invasion, survival, and epithelial-mesenchymal transition (EMT). Herein, this study aimed to investigate the effect of miR-539 on cell proliferation, apoptosis, and EMT by targeting secretory leukocyte protease inhibitor (SLPI) via the transforming growth factor β1 (TGF-β1)/Smads signaling pathway in PTC. Read More

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http://dx.doi.org/10.1002/jcb.28374DOI Listing
January 2019
2 Reads

Association Between Cancer Incidence and Mortality in Web-Based Data in China: Infodemiology Study.

J Med Internet Res 2019 Jan 29;21(1):e10677. Epub 2019 Jan 29.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. Read More

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http://dx.doi.org/10.2196/10677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371071PMC
January 2019
2 Reads
3.428 Impact Factor

[Resected Cases of Thyroid Tumor Diagnosed Class Ⅲ by Fine Needle Aspiration Cytology].

Gan To Kagaku Ryoho 2018 Dec;45(13):2114-2116

Dept. of Surgery, Tokyo Metropolitan Otsuka Hospital.

We describe 14 resected cases of thyroid tumor diagnosed as Class Ⅲ by fine needle aspiration cytology(FNA). Of these, 13 cases were diagnosed as: malignant tumor(1 case), suspicion of malignant tumor(5 cases), or were hard to distinguish from benign or malignant(7 cases). The operative methods used were total or near total thyroidectomy plus D1 or D2a in 4 cases; hemithyroidectomy plus D1 in 3 cases; subtotal thyroidectomy in 3 cases; and lobectomy of the thyroid in 4 cases. Read More

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December 2018
1 Read

Predicting Response to Immunotherapy by Evaluating Tumors, Lymphoid Cell-Rich Organs, and Immune-Related Adverse Events Using FDG-PET/CT.

Clin Nucl Med 2019 Apr;44(4):e272-e279

Division of Nuclear Medicine, Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR.

Purpose: To investigate whether the evaluation of tumors, lymphoid cell-rich organs, and immune-related adverse events (IRAE) with F-FDG PET/CT can predict the efficacy and outcome of immunotherapy.

Methods: Forty patients who underwent F-FDG-PET/CT scans before and after therapy with immune checkpoint inhibitors from December 2013 to December 2016 were retrospectively enrolled (malignant melanoma, n = 21; malignant lymphoma, n = 11; renal cell carcinoma, n = 8). SUVmax of the baseline and first restaging scans were evaluated in tumors, spleen, bone marrow, thyroid and pituitary glands, and were correlated to best overall response in the first year after therapy; IRAE-affected areas were also evaluated. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002453DOI Listing
April 2019
2 Reads

Divergence and heterogeneity of neoplastic PD-L1 expression: Two autopsy case reports of intravascular large B-cell lymphoma.

Pathol Int 2019 Jan 28. Epub 2019 Jan 28.

Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.

Intravascular large B-cell lymphoma (IVLBCL) is a distinct disease, but the neoplastic PD-L1 expression on tumor cells may vary among cases. We evaluated 10 IVLBCL autopsy cases for neoplastic PD-L1 expression, and had positive results in two cases. In one case, neoplastic PD-L1 expression (SP142, 28-8, and E1J2J clones) was dependent on the organ and anatomical site (capillaries vs. Read More

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http://dx.doi.org/10.1111/pin.12757DOI Listing
January 2019
2 Reads

Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives.

Oncol Lett 2019 Feb 20;17(2):2020-2030. Epub 2018 Dec 20.

Zhejiang Provincial Key Laboratory of Silkworm Bioreactors and Biomedicine, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China.

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in brain development. is located on the short arm of chromosome 2 (2p23) and exchange of chromosomal segments with other genes, including nucleophosmin (), echinoderm microtubule-associated protein-like 4 () and -fused gene (), readily occurs. Such chromosomal translocation results in the formation of chimeric fusion oncoproteins, which possess potential oncogenic functions due to constitutive activation of ALK kinase. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9856
Publisher Site
http://dx.doi.org/10.3892/ol.2018.9856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341817PMC
February 2019
12 Reads

The Risk of Malignancy in Korean Patients with Rheumatoid Arthritis.

Authors:
Hwajeong Lee

Yonsei Med J 2019 Feb;60(2):223-229

Division of Rheumatology, Department of Internal Medicine, Arthritis & Autoimmunity Research Center, Daegu Catholic University School of Medicine, Daegu, Korea.

Purpose: To investigate the overall cancer risk and risk for specific cancers in rheumatoid arthritis (RA) patients in Korea by comparing cancer incidence between RA patients and the general population.

Materials And Methods: Individuals diagnosed with RA between 1996 and 2009 who underwent treatment at the Daegu Catholic University Medical Center were retrospectively examined. 1885 patients with RA were included in the analyses. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.2019.60
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http://dx.doi.org/10.3349/ymj.2019.60.2.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342720PMC
February 2019
5 Reads

ROS1-rearranged high-PD-L1-expressing lung adenocarcinoma manifesting as mediastinal tumor: A case report.

Oncol Lett 2019 Jan 25;17(1):488-491. Epub 2018 Oct 25.

Division of Thoracic Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650-0017, Japan.

ROS proto-oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer is rare and comprises only 1% of lung adenocarcinoma cases. It has recently been reported to have good response to crizotinib, a tyrosine kinase inhibitor of anaplastic lymphoma kinase. Driver oncogene mutations with approved therapies seldom coexist with a high expression of Programmed death-ligand 1 (PD-L1). Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9622
Publisher Site
http://dx.doi.org/10.3892/ol.2018.9622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313173PMC
January 2019
9 Reads

Simultaneous Hodgkin lymphoma and BRAFV600E-positive papillary thyroid carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14180

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China.

Rationale: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. However, the simultaneous occurrence of PTC and Hodgkin Lymphoma (HL) was rarely reported.

Patient Concerns: We present a case of simultaneous BRAF-positive PTC and HL in a 17-year-old female. Read More

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http://dx.doi.org/10.1097/MD.0000000000014180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370130PMC
January 2019
2 Reads

Patient-Reported Survivorship Care Practices and Late Effects After Treatment of Hodgkin and Non-Hodgkin Lymphoma.

JCO Clin Cancer Inform 2018 12;2:1-10

All authors: University of Pennsylvania, Philadelphia, PA.

Purpose: Multimodal treatment of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) yields excellent outcomes; however, survivors are at risk of developing myriad late and long-term effects.

Methods: From a convenience sample of 964 survivors of HL (37%) and NHL (63%) using a publicly available Internet-based survivorship care plan (SCP) tool between 2011 and 2016, we examined patient-reported cancer care, toxicities, and survivorship care data.

Results: Of all survivors, 67% were female and 84% were white and 88% were free of cancer. Read More

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http://dx.doi.org/10.1200/CCI.18.00015DOI Listing
December 2018
1 Read

Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study.

JAMA Netw Open 2018 Jun 1;1(2):e180349. Epub 2018 Jun 1.

Survivorship Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.

Importance: As survival rates from cancer have improved dramatically over the last decades, there is a need to explore the long-term consequences. Adolescents and young adults with cancer are at risk for several therapy-related late effects; however, these have not been studied extensively.

Objective: To investigate the lifetime risks of endocrine late effects of cancer and cancer treatment in adolescent and young adult cancer survivors. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324403PMC
June 2018
3 Reads

Spontaneous Regression of Primary Thyroid Lymphoma: Two Rarities at the Same Time.

Turk Patoloji Derg 2019 Jan 11. Epub 2019 Jan 11.

Department of Pathology, University General Hospital of Alicante, ALICANTE, SPAIN.

Primary thyroid lymphomas are pretty uncommon, and constitute about 5% of the neoplasms of this organ. Spontaneous tumor regression is defined as the total or partial disappearance of a tumor as proven by microscope without treatment or under inadequate treatment. It is estimated to happen in one out of 60,000-100,000 cases. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01445DOI Listing
January 2019
1 Read

Do doctors who order more routine medical tests diagnose more cancers? A population-based study from Ontario Canada.

Cancer Med 2019 Feb 4;8(2):850-859. Epub 2019 Jan 4.

ICES Queens, Queen's University, Kingston, Ontario, Canada.

Background: The overuse of medical tests leads to higher costs, wasting of resources, and the potential for overdiagnosis of disease. This study was designed to determine whether the patients of family doctors who order more routine medical tests are diagnosed with more cancers.

Method: A retrospective population-based cross-sectional study using administrative health care data in Ontario Canada. Read More

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http://dx.doi.org/10.1002/cam4.1925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382726PMC
February 2019
1 Read

Cancer risk in children and young adults born preterm: A systematic review and meta-analysis.

PLoS One 2019 4;14(1):e0210366. Epub 2019 Jan 4.

Department of Pediatrics, Sainte-Justine University Hospital and Research Center, University of Montreal, Montreal, Quebec, Canada.

Introduction: Risk of developing a malignancy when born premature is unknown. We hypothesised that risk of certain cancers might be increased in youth born preterm versus term. We therefore performed a systematic review and meta-analysis to evaluate the incidence of malignancy in the context of preterm birth, according to various cancer types. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210366PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319724PMC
January 2019
9 Reads

Ultrasonography in the Diagnosis and Monitoring of Therapy for Primary Thyroid Lymphoma.

Authors:
Peng Li Hui Zhang

Ultrasound Q 2018 Dec 28. Epub 2018 Dec 28.

Department of Ultrasound, Peking University First Hospital, Beijing, China.

This study aims to evaluate the value of ultrasonography in the diagnosis, treatment, and follow-up of primary thyroid lymphoma. The clinical data of 12 patients, who were pathologically confirmed with thyroid lymphoma and treated in our hospital, were retrospectively analyzed. Ultrasonography was performed on the thyroid and neck lymph nodes, and the sonographic features of the lesions were recorded. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000414DOI Listing
December 2018
3 Reads

Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.

Acta Oncol 2019 Feb 26;58(2):227-231. Epub 2018 Dec 26.

a Childhood Cancer Research Group , Danish Cancer Society Research Center , Copenhagen , Denmark.

Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail.

Material And Methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1
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http://dx.doi.org/10.1080/0284186X.2018.1535187DOI Listing
February 2019
12 Reads

Fine-needle aspiration to diagnose primary thyroid lymphoma: a systematic review and meta-analysis.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

P Trimboli, Department of Nuclear Medicine and Thyroid Centre, Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland.

Background: Primary thyroid lymphoma (PTL) is a rare malignancy, and its prognosis depends significantly on its early diagnosis. While fine needle aspiration (FNA) represents the gold standard to identify differentiated thyroid carcinoma, its reliability for the detection of PTL is still unclear. Here we conducted a systematic review and meta-analysis to evaluate the diagnostic performance of FNA in PTL. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0672DOI Listing
December 2018
9 Reads

New and emerging renal entities: a perspective post-WHO 2016 classification.

Histopathology 2019 Jan;74(1):31-59

Charles University and University Hospital Pilsen, Pilsen, Czech Republic.

Renal tumours include a heterogeneous and diverse spectrum of neoplasms. Recent advances in this field have significantly improved our understanding of the morphological, immunohistochemical, molecular, epidemiological and clinical characteristics of renal tumours, which led to the new Vancouver classification of renal neoplasia and the new World Health Organization (WHO) classification of renal cell tumours. This review aims to summarise the new information and evidence on several new and emerging/provisional renal entities, which were mostly generated after the recent classification of renal neoplasia. Read More

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http://dx.doi.org/10.1111/his.13727DOI Listing
January 2019
5 Reads
3.453 Impact Factor

Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma-identification of high-risk populations to guide surveillance: A report from the Late Effects Study Group.

Cancer 2018 Dec 17. Epub 2018 Dec 17.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations.

Methods: The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. Read More

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http://dx.doi.org/10.1002/cncr.31807DOI Listing
December 2018
1 Read

Patient-Centered Medical Homes in Community Oncology Practices: Changes in Spending and Care Quality Associated With the COME HOME Experience.

J Oncol Pract 2019 Jan 5;15(1):e56-e64. Epub 2018 Dec 5.

4 Innovative Oncology Business Solutions, Albuquerque, NM.

Purpose:: We examined whether the Community Oncology Medical Home (COME HOME) program, a medical home program implemented in seven community oncology practices, was associated with changes in spending and care quality.

Patients And Methods:: We compared outcomes from elderly fee-for-service Medicare beneficiaries diagnosed between 2011 and 2015 with breast, lung, colorectal, thyroid, or pancreatic cancer, lymphoma, or melanoma and served by COME HOME practices before and after program implementation versus similar beneficiaries served by other geographically proximate oncologists. Difference-in-differences analysis compared changes in outcomes for COME HOME patients versus concurrent controls. Read More

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http://dx.doi.org/10.1200/JOP.18.00479DOI Listing
January 2019
3 Reads

The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis.

Arthritis Res Ther 2018 Dec 6;20(1):270. Epub 2018 Dec 6.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.

Background: Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types.

Methods: Online databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Read More

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http://dx.doi.org/10.1186/s13075-018-1760-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282326PMC
December 2018
2 Reads

Reconstruction of anterior chest wall: a clinical analysis.

J Cardiothorac Surg 2018 Dec 7;13(1):124. Epub 2018 Dec 7.

Department of thoracic surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Objective: To investigate the methods and clinical efficacy of reconstruction of chest defects with titanium sternal fixation system after the surgical resection of sternal tumors.

Methods: A total of 6 patients with sternal tumor who were diagnosed and underwent resection and repair of the chest wall defects by titanium plates system, from 2017.3 to 2017. Read More

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https://cardiothoracicsurgery.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13019-018-0810-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286520PMC
December 2018
13 Reads
1.018 Impact Factor

Trends in the incidence and mortality of cancer in Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

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https://www.smj.org.sa/index.php/smj/article/view/smj.2018.1
Publisher Site
http://dx.doi.org/10.15537/smj.2018.12.23348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344657PMC
December 2018
7 Reads

Dosimetric comparison of anterior posterior-posterior anterior 2-field three-dimensional conformal radiotherapy, 4-field three-dimensional conformal radiotherapy and "forward" plan intensity modulated radiotherapy techniques in female lymphoma patients irradiated to neck and mediastinum.

J Cancer Res Ther 2018 Oct-Dec;14(6):1389-1396

Department of Radiation Oncology, Dokuz Eylül University Medical Faculty, Izmir, Turkey.

Aim: Dosimetric comparison of three different techniques in female lymphoma patients who had radiotherapy (RT) to the neck and mediastinum.

Setting And Design: Retrospective clinical study.

Materials And Methods: Computerized tomography-simulator images of eight patients were obtained retrospectively. Read More

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http://dx.doi.org/10.4103/0973-1482.193108DOI Listing
February 2019
4 Reads

Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 28;257(2):405-411. Epub 2018 Nov 28.

Department of Oculoplastic, Orbital, and Lacrimal Surgery, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Purpose: To examine the clinicopathological characteristics of patients with thyroid eye disease (TED) who showed asymmetric lacrimal gland enlargement.

Methods: Sixteen patients were included in this retrospective, observational case series. The following data were collected: sex, age, laterality, past medical history, laboratory results for thyroid function and other autoimmune disorders, pathological results, other systemic lesions related to lacrimal gland pathology, and the clinical course after treatment. Read More

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http://dx.doi.org/10.1007/s00417-018-4197-0DOI Listing
February 2019
3 Reads

Bilateral Proptosis in a Child: A Rare Presentation of Acute Lymphoblastic Leukemia.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):511-513

Division of Pediatric Hematogy/Oncology, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Purpose: Acute lymphoblastic leukemia (ALL), a common hematological malignancy observed in children, typically presents with fever, pallor, easy bruising, hepatosplenomegaly and lymphadenopathy. However, when ALL manifests with unusual signs and the blood counts and peripheral smears are normal, it causes a diagnostic dilemma.

Case Report: We report a 5-year-old boy who presented with bilateral proptosis as the initial manifestation of ALL. Read More

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http://dx.doi.org/10.4103/jovr.jovr_2_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210864PMC
November 2018
2 Reads