4,009 results match your criteria Thyroid Lymphoma


Should uncertainty concerning the risk of malignancy be included in diagnostic (nongynecologic) cytopathology reports?

Cancer Cytopathol 2020 Jul 10. Epub 2020 Jul 10.

Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exact nature of the specimen received, the staining method(s) used, and the use of additional laboratory techniques including molecular profiling; furthermore, they often differ to some extent from institution to institution, between differing cytologists within the same institution, and over time. A brief literature review for a selected group of routine diagnostic cytology specimens shows a published ROM for a confirmed malignant diagnosis as follows: bile duct brushings, ~99% (range, 97%-100%); breast fine needle aspiration, 98. Read More

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http://dx.doi.org/10.1002/cncy.22322DOI Listing

Low T3 syndrome is a prognostic marker of poor outcomes in secondary hemophagocytic lymphohistiocytosis.

Leuk Lymphoma 2020 Jul 9:1-8. Epub 2020 Jul 9.

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.

This study aimed to examine the association between low T3 syndrome and overall survival (OS) in patients with secondary hemophagocytic lymphohistiocytosis (sHLH). The study consisted of 111 consecutive patients hospitalized due to newly diagnosed sHLH with detailed thyroid hormone profiles on admission. Low T3 syndrome was found in 75. Read More

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http://dx.doi.org/10.1080/10428194.2020.1789623DOI Listing

Prevalence and diagnostic challenges of thyroid lymphoma: a multi-institutional study in non-Western countries.

Endocr J 2020 Jul 9. Epub 2020 Jul 9.

Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan.

Research on the primary thyroid lymphoma (PTL) diagnosis is limited, with only a few large sample size studies, reported from Asian countries. The aim of the present study was to clarify the current prevalence and challenges in PTL diagnosis, and recommended ancillary studies for PTL in non-Western countries. PTL (n = 153) cases were retrieved from 10 institutions in non-Western countries and analyzed. Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0202DOI Listing

Diagnostic and prognostic value of a 7-panel mutation testing in thyroid nodules with indeterminate cytology: the SWEETMAC study.

Endocrine 2020 Jul 7. Epub 2020 Jul 7.

Thyroid and Endocrine Tumors Unit, Institute of Endocrinology, Pitié Salpêtrière Hospital, IUC Sorbonne University, Paris, France.

Purpose: The aim of this prospective study (ClinicalTrials.gov: NCT01880203) was to evaluate the diagnostic and prognostic value of a 7-panel mutation testing in the aspirates of thyroid nodules with indeterminate cytology (IC).

Methods: Eligible patients had a thyroid nodule ≥15 mm with IC (Bethesda III-V) for which surgery had been recommended. Read More

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http://dx.doi.org/10.1007/s12020-020-02411-4DOI Listing

Sjögren Syndrome and Cancer.

Rheum Dis Clin North Am 2020 Aug;46(3):513-532

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; US Department of Veterans Affairs, Oklahoma City, OK, USA. Electronic address:

The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.004DOI Listing

Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors.

BMC Genomics 2020 Jul 6;21(1):464. Epub 2020 Jul 6.

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Background: T zone lymphoma (TZL), a histologic variant of peripheral T cell lymphoma, represents about 12% of all canine lymphomas. Golden Retrievers appear predisposed, representing over 40% of TZL cases. Prior research found that asymptomatic aged Golden Retrievers frequently have populations of T zone-like cells (phenotypically identical to TZL) of undetermined significance (TZUS), potentially representing a pre-clinical state. Read More

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http://dx.doi.org/10.1186/s12864-020-06872-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339439PMC

Rituximab is not associated with increased risk of second primary malignancies in Israeli patients with diffuse large B cell lymphoma treated with RCHOP regimen.

Leuk Lymphoma 2020 Jul 1:1-7. Epub 2020 Jul 1.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

It is unknown whether rituximab increases the risk of second primary malignancies (SPMs) in patients with diffuse large cell B-cell lymphoma (DLBCL). We assessed SPMs in DLBCL patients diagnosed between 1996 and 2014 in comparison with the general Israeli population and dependent on rituximab treatment. Jewish patients had no increased risk for SPMs. Read More

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http://dx.doi.org/10.1080/10428194.2020.1779257DOI Listing

The diagnosis of primary thyroid lymphoma by fine-needle aspiration, cell block, and immunohistochemistry technique.

Diagn Cytopathol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Aim: Primary thyroid lymphoma (PTL) is a rare malignant disease. Its prognosis depends on early diagnosis. The role of fine-needle aspiration (FNA), including smear cytology, cell block (CB) techniques, and immunohistochemistry (IHC) sections in the diagnosis of PTL is still unclear. Read More

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http://dx.doi.org/10.1002/dc.24526DOI Listing

Risk of Second Primary Bone and Soft-Tissue Sarcomas Among Young Adulthood Cancer Survivors.

JNCI Cancer Spectr 2019 Sep 20;3(3):pkz043. Epub 2019 Jun 20.

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.

Excess sarcoma risks after childhood cancer are well established, but risks among young adulthood cancer survivors are poorly understood. Using US population-based cancer registry data, we compared bone and soft-tissue sarcoma risk vs the general population among 186 351 individuals who were diagnosed with nonsarcoma first primary malignancies at ages 20-39 years from 1975 to 2014 (follow-up through 2015) and survived at least 1 year. Bone sarcomas were rare (n = 50), but risk was statistically significantly elevated overall (2. Read More

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http://dx.doi.org/10.1093/jncics/pkz043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049991PMC
September 2019

An Unusual Cause of Mediastinal Mass and Chylothorax.

Int J Appl Basic Med Res 2020 Apr-Jun;10(2):143-146. Epub 2020 Apr 2.

Department of Pulmonary Medicine, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Mediastinal masses are commonly encountered in clinical practice. The commonly encountered anterior mediastinal masses include those of thymic or thyroid origin, teratomas, and lymphoma. Establishing the diagnosis by histopathology is essential considering the wide range of differential diagnosis and to exclude malignancies. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_6_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289211PMC

Spontaneous neoplasia in captive syngnathid species: A retrospective case series (2003-2014) and literature review.

J Fish Dis 2020 Jun 18. Epub 2020 Jun 18.

International Zoo Veterinary Group, Station House, Keighley, UK.

Syngnathidae (seahorses, pipefish and seadragons) are charismatic species commonly kept in commercial aquaria, but published literature on syngnathid diseases is limited and immunohistochemical techniques not routinely employed. A retrospective review of 2,541 syngnathid submissions received between March 2003 and October 2016 identified 18 neoplasms including germ cell tumours, exocrine pancreatic and intestinal carcinomas, chromatophoromas, and single cases of lymphoma, thyroid and renal carcinoma, swim bladder and pituitary adenoma. Big-bellied seahorses accounted for 19% of submissions, but 50% of neoplasms were diagnosed in this species. Read More

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http://dx.doi.org/10.1111/jfd.13203DOI Listing

Approach to primary thyroid lymphoma: case series.

Turk J Surg 2019 Jun 13;35(2):142-145. Epub 2019 Jun 13.

İzmir Katip Çelebi Üniversitesi, Atatürk Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İzmir, Türkiye.

Primary thyroid lymphomas are rare thyroid neoplasms. Mucosa Associated Lymphoid tissue (MALT) lymphoma and diffuse large B-cell Non-Hodgkin lymphoma are the most common types. It is more common in the elderly, and especially in women. Read More

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http://dx.doi.org/10.5578/turkjsurg.4132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796069PMC

t(3;14)(p14.1;q32)/FOXP1-IGH translocation in thyroid extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).

Leuk Res 2020 Aug 2;95:106399. Epub 2020 Jun 2.

Department of Pathology, Showa University School of Medicine, Japan.

Objectives: MALT lymphoma occurs in various organs and has several characteristic genetic aberrations. Thyroid MALT lymphoma has been reported to include t(3;14)(p14.1;q32)/FOXP1-IGH as a specific genetic aberration, but the number of studies is limited. Read More

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http://dx.doi.org/10.1016/j.leukres.2020.106399DOI Listing

Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis.

Diagn Cytopathol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: Cancer genome profiling of cytology specimens using next-generation sequencing (NGS) requires adequate and good-quality DNA. Genomic examination of cytology samples was conventionally performed on cell block (CB) or smear specimens than on residual liquid-based cytology (LBC) specimens, which are high-quality DNA sources even after long-term storage.

Methods: We estimated tumor fractions of 37 residual LBC specimens, including 30 fine needle aspiration (FNA) samples from the thyroid (12 papillary thyroid carcinomas and two malignant lymphomas), lymph node (13 metastatic carcinomas and one malignant lymphoma), and breast cancer (one phyllodes tumor and one invasive ductal carcinoma), two pancreatic carcinoma samples, and five liquid (ascites, pleural effusion, and cerebrospinal fluid) samples. Read More

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http://dx.doi.org/10.1002/dc.24511DOI Listing

Progressively Enlarging Goiter: Case Reports of Primary Thyroid Lymphoma and Literature Review.

Curr Med Sci 2020 May 30. Epub 2020 May 30.

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Primary thyroid lymphoma (PTL) is an exceptionally rare and highly aggressive potentially curable malignant disease. We report three typical cases of PTL referred to our hospital. All three cases had long history of Hashimoto's thyroiditis, and presented with progressively enlarging neck mass. Read More

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http://dx.doi.org/10.1007/s11596-020-2204-2DOI Listing

Fertility in female cancer survivors: a systematic review and meta-analysis.

Reprod Biomed Online 2020 Jul 22;41(1):96-112. Epub 2020 Feb 22.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Department of Obstetetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via M. Fanti, 6, 20122, Milan, Italy.

Data on the effects of cancer treatments on fertility are conflicting. The aim of the present systematic review and meta-analysis was to determine the chances of childbirth in women survivors of different types of cancer. PubMed, MEDLINE, Embase and Scopus were searched from database inception to 17 July 2019 for published cohort, case-control and cross-sectional studies that investigated the reproductive chances in women survivors of different cancer types. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.02.008DOI Listing

ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto's thyroiditis: report of a rare case and a literature review.

Diagn Pathol 2020 May 19;15(1):58. Epub 2020 May 19.

Department of Pathology, the Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: Inflammatory myofibroblastic tumors (IMTs) of the thyroid are extremely rare soft-tissue tumors. In the literature, IMTs are sometimes called plasma cell granulomas (PCGs) or inflammatory pseudotumors, which often causes ambiguity. To date, 17 cases of PCGs and five cases of thyroid IMTs have been reported. Read More

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http://dx.doi.org/10.1186/s13000-020-00966-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236920PMC

The Synchronous Presence of Multiple Myelomas and Other Primary Malignant Tumors: Case Series with Literature Review.

Cancer Manag Res 2020 24;12:2829-2838. Epub 2020 Apr 24.

Henan Institute of Haematology, Department of Hematology, Henan Cancer Hospital, Henan Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, People's Republic of China.

Objective: The synchronous presence of multiple myeloma (MM) and other primary malignant tumors (PMTs) were rarely reported. This study aimed to analyze several cases of MM and other PMTs in order to improve clinicians' understanding of multiple myeloma (MM) with sMPMTs.

Methods: This study was a retrospective trial. Read More

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http://dx.doi.org/10.2147/CMAR.S238288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187932PMC

Role of miR-155-5p expression and its involvement in apoptosis-related factors in thyroid follicular carcinoma.

J Clin Pharm Ther 2020 Aug 15;45(4):660-665. Epub 2020 May 15.

Department of Thyroid and Breast Surgery, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.

What Is Known And Objective: Thyroid follicular carcinoma is a malignant tumor from thyroid follicular epithelium, which is prone to involve capsular and vascular invasion. The present study was conducted in order to detect the expression of microRNA-155-5p (miR-155-5p) in thyroid follicular carcinoma with an attempt to analyze its involvement in apoptosis-related factors.

Methods: Forty-five patients with thyroid follicular carcinoma made up the observation group and 45 patients with thyroid follicular adenoma were included into the control group. Read More

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http://dx.doi.org/10.1111/jcpt.13175DOI Listing
August 2020
1.533 Impact Factor

Cancer Among Adolescents and Young Adults Between 2000 and 2016 in France: Incidence and Improved Survival.

J Adolesc Young Adult Oncol 2020 May 15. Epub 2020 May 15.

Registre National des Cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vandœuvre-lès-Nancy, France.

This study was undertaken to determine cancer survival and describe the spectrum of cancers diagnosed among French adolescent and young adult (AYA) population. All cases of cancer diagnosed in 15-24 years, recorded by all French population-based registries (18% of the French population), over the 2000-2016 period, were included. Age-standardized incidence rates, conventional annual percentage change (cAPC) of incidence over time, and 5-year overall survival (5yOS) were calculated. Read More

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http://dx.doi.org/10.1089/jayao.2020.0017DOI Listing

[Comparisons of clinical characteristics and prognosis between patients with primary and secondary thyroid lymphoma].

Zhonghua Xue Ye Xue Za Zhi 2019 Jul;40(7):568-572

Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, State Key Laboratory of Medical Genomics, Shanghai 200025, China.

To compare clinical characteristics and prognosis between patients with primary (PTL) and secondary thyroid lymphoma (STL) . A retrospective analysis was performed on 46 patients with thyroid lymphoma (PTL 19, STL 27) from January 2002 to October 2018. ①PTL group included 4 males and 15 females, with a median age of 57 years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.07.006DOI Listing

Mucosa-associated lymphoid tissue (MALT) lymphoma developing in ectopic mediastinal thyroid tissue: a case report.

Surg Case Rep 2020 May 11;6(1):97. Epub 2020 May 11.

Department of pathology, Matsue City Hospital, 32-1, Noshira-cho, Matsue, Shimane, 690-8509, Japan.

Background: Normally located in the neck, ectopic mediastinal thyroid tissue consists of very rare ectopic thyroid tissue that does not connect to the thyroid gland. A patient with mucosa-associated lymphoid tissue (MALT) lymphoma that has developed in mediastinal thyroid tissue, to our best knowledge, has not been previously reported.

Case Presentation: A 67-year-old woman presented with a superior mediastinal mass that was revealed by chest computed tomography (CT), an optional examination she hoped, during a medical checkup. Read More

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http://dx.doi.org/10.1186/s40792-020-00857-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214558PMC

Magnolin Inhibits Proliferation and Invasion of Breast Cancer MDA-MB-231 Cells by Targeting the ERK1/2 Signaling Pathway.

Chem Pharm Bull (Tokyo) 2020 ;68(5):421-427

Department of Clinical Laboratory, The First College of Clinical Medical Science, China Three Gorges University.

The aim of this study was to evaluate the effects of Magnolin (MGL) on inhibition of human breast cancer cells, and explore the underlying molecular mechanisms. The viability of the treated cells was assessed with the Cell Counting Kit-8 (CCK-8) assay, and the proliferation was analyzed in terms of EdU uptake, colony formation, and flow cytometry. The in vitro invasion and migration were determined by the transwell and wound healing assays respectively. Read More

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http://dx.doi.org/10.1248/cpb.c19-00820DOI Listing
January 2020

NOT JUST HASHIMOTO'S THYROIDITIS.

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):537-538

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

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http://dx.doi.org/10.4183/aeb.2019.537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200110PMC

Bipolar Spectrum Disorder May Be Associated With Family History of Diseases.

J Clin Med Res 2020 Apr 30;12(4):251-254. Epub 2020 Mar 30.

Uskudar University, NPIstanbul Brain Hospital, Istanbul, Turkey.

Background: This study aims at investigating into the presence of family history of diabetes, ischemic heart disease, thyroid disease, cancer, cerebrovascular disease, and epilepsy in bipolar patients.

Methods: Totally 1,148 patients admitted to our outpatient unit between January 2018 and January 2020, who were diagnosed with bipolar disorder according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V), from whom informed consent was obtained, were cross-sectionally and consecutively evaluated. Each patient was questioned regarding a family history of diabetes, ischemic heart disease, thyroid disease, cancer (gastrointestinal, breast and prostate cancer, leukemia, and lymphoma), cerebrovascular disease and epilepsy in first- and second-degree relatives. Read More

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http://dx.doi.org/10.14740/jocmr4143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188371PMC

Multidetector computed tomography evaluation of synchronous lymphoma and other solid malignancies.

J Cancer Res Ther 2020 Jan-Mar;16(1):60-65

Department of Occupational Health and Industrial Medicine, Public Health and Community Medicine, Mansoura Faculty of Medicine, Mansoura University, Mansoura University, Mansoura, Egypt.

Objective: The objective of this study is to review the multidetector computed tomography (MDCT) findings of synchronous lymphoma and other solid malignancies.

Patients And Methods: This retrospective study included 18 patients confirmed with diagnosis of lymphoma and other solid malignancies. They were 8 women and 10 men (mean age, 62. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_325_17DOI Listing

Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers.

J Cancer Res Clin Oncol 2020 Jul 30;146(7):1765-1779. Epub 2020 Apr 30.

Department of Clinical Analytics and Insights, Center for Clinical Excellence, SSM Health, Saint Louis, MO, USA.

Purpose: As the number of cancer survivors in the United States increases, quantifying the risks and burden of second primary cancers (SPCs) among cancer survivors will help develop long-term prevention and surveillance strategies. We describe the risk of developing a SPC among survivors of 10 cancer sites with the highest survival rates in the United States.

Methods: Adult patients diagnosed with an index smoking-related (urinary bladder, kidney and renal pelvis, uterine cervix, oral cavity and pharynx, and colon and rectum) and index non-smoking-related (prostate, thyroid, breast, corpus and uterus, and non-Hodgkin lymphoma) cancers were identified from Surveillance, Epidemiology, and End Results (2000-2015). Read More

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http://dx.doi.org/10.1007/s00432-020-03232-8DOI Listing

Cancer incidence and mortality trends in young adults in Metropolitan Lima young adults, 1990-2012.

Ecancermedicalscience 2020 20;14:1025. Epub 2020 Apr 20.

Department of Nuclear Medicine, National Institute of Neoplastic Diseases, Lima, Peru.

Aims: The purpose of this research was to calculate and compare standardised incidence and mortality ratios in young adults, based on the data published by the population-based cancer registry of Metropolitan Lima.

Method: A secondary analysis was carried out on the data published by the population-based cancer registry of Metropolitan Lima in its last five volumes. Calculating the standardised incidence ratio, in accordance with the World Health Organization's standard population, was done using the direct method, and the annual percentage change was calculated using the Joinpoint Regression Program. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176066PMC

Exposure to Tomographic Scans and Cancer Risks.

JNCI Cancer Spectr 2020 Feb 14;4(1):pkz072. Epub 2019 Nov 14.

Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downtown Medical Center, Brooklyn, NY.

Background: Worldwide use of computed tomography (CT) scans has increased. However, the ionizing radiation from CT scans may increase the risk of cancer. This study examined the association between medical radiation from CT scans and the risk of thyroid cancer, lymphoma, and non-Hodgkin lymphoma (NHL) in adults. Read More

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http://dx.doi.org/10.1093/jncics/pkz072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050152PMC
February 2020

Familial Aggregation and Heritability of Nonmedullary Thyroid Cancer in an Asian Population: A Nationwide Cohort Study.

J Clin Endocrinol Metab 2020 Jul;105(7)

Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Purpose: The purpose of this work is to assess the extent of familial aggregation of nonmedullary thyroid cancer (NMTC) and the relative risks (RRs) of chronic thyroid diseases and common malignancies in first-degree relatives of NMTC patients.

Methods: In the National Health Insurance Research database of Taiwan, all eligible individuals in 2016 were analyzed (n = 23 696 659) and the family structures of 38 686 patients diagnosed with NMTC between 1997 and 2016 were identified. The prevalence and RRs of NMTC, chronic thyroid diseases, and common malignancies in individuals with first-degree relatives with NMTC were examined. Read More

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http://dx.doi.org/10.1210/clinem/dgaa191DOI Listing

The Emerging Crisis of Stakeholders in Implant-based Augmentation Mammaplasty in Korea.

J Korean Med Sci 2020 Apr 20;35(15):e103. Epub 2020 Apr 20.

Department of Surgery, Breast Cancer Center, Gachon University Gil Medical Center, Incheon, Korea.

Background: Korea is no longer safe from the risk of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL); the first reported case was a Korean woman in her 40s who had a 7-year-history of receiving an implant-based augmentation mammaplasty using a textured implant. We conducted this study to discuss the emerging crisis of stakeholders in implant-based augmentation mammaplasty and to propose a multi-disciplinary approach to early detection of its complications.

Methods: We analyzed medical examination data that was collected from patients who visited us between August 12 and September 27, 2019. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167397PMC

Novel Findings on SPECT-CT Tc-99 Sestamibi Imaging for Primary Hyperparathyroidism.

J Surg Res 2020 Aug 11;252:216-221. Epub 2020 Apr 11.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Background: The addition of SPECT-CT to Tc-99 sestamibi has become a valuable tool for parathyroid localization in primary hyperparathyroidism (PHP). However, the enhanced sensitivity of this test can lead to unexpected and significant findings. We sought to identify the frequency and types of nonparathyroid detections by SPECT-CT. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.014DOI Listing

SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.

Arch Pathol Lab Med 2020 Apr 9. Epub 2020 Apr 9.

From the Departments of Pathology (Drs Nambirajan, Bhardwaj, and Jain and Ms Singh) and Pulmonary Medicine (Dr Mittal), All India Institute of Medical Sciences, New Delhi, India; and the Department of Surgical Oncology, Dr B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India (Dr Kumar).

Context.—: Somatic mutations in (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4) gene and/or BRG1 (Brahma-related gene 1) loss identifies a subset of non-small cell lung carcinomas (NSCLCs) lacking alterations in (epidermal growth factor receptor), (anaplastic lymphoma kinase), and (ROS proto-oncogene 1) genes. Preliminary observations suggest responsiveness to immunotherapy and targeted therapies. Read More

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http://dx.doi.org/10.5858/arpa.2019-0633-OADOI Listing
April 2020
2.838 Impact Factor

Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH.

J Clin Endocrinol Metab 2020 Aug;105(8)

Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health and Moores Cancer Center, University of California, San Diego, La Jolla, California.

Context: Many female survivors of adolescent and young adult cancers (AYA survivors) have shortened reproductive lifespans. However, the timing and duration of ovarian function after cancer treatment are largely unknown.

Objective: To model the trajectory of ovarian function over two decades following cancer treatment and evaluate how trajectories vary by treatment gonadotoxicity and age. Read More

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http://dx.doi.org/10.1210/clinem/dgaa172DOI Listing

A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis.

Diagn Pathol 2020 Apr 7;15(1):34. Epub 2020 Apr 7.

Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.

Background: Ulcerative colitis (UC) is one of the major types of inflammatory bowel diseases and is associated with a significantly increased risk of not only lymphoproliferative disorders but also lymphomas, of which most cases are related to the long-term usage of immunosuppressants. Here, we demonstrate a very rare case of other iatrogenic immunodeficiency-associated colonic diffuse large B-cell lymphoma (Oii-DLBCL) complicating UC and rectal perforation. In addition, we reviewed the clinicopathological features of previous cases of DLBCL related to UC. Read More

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http://dx.doi.org/10.1186/s13000-020-00954-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137478PMC

Nonseminomatous Extragonadal Germ Cell Tumor Presenting As Early Pericardial Tamponade.

Cureus 2020 Feb 28;12(2):e7131. Epub 2020 Feb 28.

Internal Medicine, King Edward Medical University/Mayo Hospital, Lahore, PAK.

Multiple different types of mediastinal masses may be encountered on imaging techniques in symptomatic and asymptomatic patients. The most frequent mediastinal masses in adults are thymoma, lymphoma, thyroid masses, and germ cell tumors. Potential complications of these masses due to localized invasion include hemoptysis, post-obstructive pneumonia, and superior vena cava syndrome. Read More

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http://dx.doi.org/10.7759/cureus.7131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105248PMC
February 2020

PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer.

Comput Struct Biotechnol J 2020 19;18:668-675. Epub 2020 Mar 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational methods for predicting MSI are based on DNA sequencing data and a few are based on mRNA expression data. Read More

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http://dx.doi.org/10.1016/j.csbj.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113609PMC

Possible Relationship between Long-Term Adverse Health Effects of Gonad-Removing Surgical Sterilization and Luteinizing Hormone in Dogs.

Animals (Basel) 2020 Apr 1;10(4). Epub 2020 Apr 1.

Department of Animal and Rangeland Sciences, Oregon State University, 112 Withycombe Hall, Corvallis, OR 97370, USA.

Spaying and neutering dogs is commonly used to prevent the birth of unwanted animals and eliminate the risk of reproductive diseases. However, removal of the gonads prevents the feedback of estrogen and testosterone on the pituitary and hypothalamus. As a result, luteinizing hormone (LH) is continuously elevated at supraphysiologic concentrations. Read More

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http://dx.doi.org/10.3390/ani10040599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222805PMC

Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.

PLoS One 2020 30;15(3):e0230721. Epub 2020 Mar 30.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Background: A number of studies have reported on associations between reproductive factors, such as delivery methods, number of birth and breastfeeding, and incidence of cancer in children, but systematic reviews addressing this issue to date have important limitations, and no reviews have addressed the impact of reproductive factors on cancer over the full life course of offspring.

Methods: We performed a comprehensive search in MEDLINE, and Embase up to January 2020 and Web of Science up to 2018 July, including cohort studies reporting the association between maternal reproductive factors of age at birth, birth order, number of births, delivery methods, and breastfeeding duration and cancer in children. Teams of two reviewers independently extracted data and assessed risk of bias. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230721PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105118PMC

Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway.

Front Oncol 2020 11;10:217. Epub 2020 Mar 11.

Key Laboratory of Cancer Prevention and Therapy, Department of Thyroid and Neck Tumor, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Patients with metastatic radioiodine-refractory papillary thyroid carcinoma (PTC) have limited treatment options and a poor prognosis. There is an urgent need to develop new drugs targeting PTC for clinical application. Apatinib, a novel small-molecule tyrosine kinase inhibitor (TKI), is highly selective for vascular endothelial growth factor receptor-2 (VEGFR2) and exhibits antitumor effects in a variety of solid tumors. Read More

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http://dx.doi.org/10.3389/fonc.2020.00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078169PMC

Orbital pseudotumor as the presenting symptom of Crohn's disease in a male child.

Am J Ophthalmol Case Rep 2020 Jun 16;18:100669. Epub 2020 Mar 16.

University of Nebraska Medical Center, S 42nd St & Emile St, Omaha, NE, 68198, USA.

Purpose: This report will describe a case of orbital pseudotumor that is associated with underlying Crohn's disease in a pediatric patient.

Observations: An 8-year-old male with a past medical history of chronic constipation who presented to the ophthalmologist in July 2017 with a 7-month history double vision, left upper lid ptosis, left abducens nerve palsy, and an abnormal thyroid test. The patient's family history was negative for any autoimmune disease including, juvenile idiopathic arthritis, rheumatoid arthritis, thyroid disease, type 1 diabetes mellitus or inflammatory bowel disease. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090333PMC

Rare case of Richter's syndrome localization in liver and thyroid of a patient with a chronic lymphocytic leukemia (CLL) - Case report and literature.

Ann Agric Environ Med 2020 Mar 9;27(1):160-164. Epub 2019 Apr 9.

Chair and Department of Haematooncology and Bone Marrow Transplantation, Medical University, Lublin, Poland.

Richter's syndrome (RS) is a rare complication in which chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL) transforms into a more aggressive type of lymphoma - diffuse large B cell lymphoma (DLBCL), or Hodgkin's lymphoma (HL). The review describes the clinical case of a patient with CLL and RS diagnosis. A computed tomography (CT) scan of the abdominal cavity detected numerous normodense areas in the liver. Read More

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http://dx.doi.org/10.26444/aaem/106041DOI Listing

[IgG4-associated disease in differential diagnosis of inflammatory orbitopathy].

Probl Endokrinol (Mosk) 2019 11 23;65(5):367-372. Epub 2019 Nov 23.

National research center for hematology.

IgG4-associated disease (IgG4-RD) is a systemic inflammatory disease characterized by tumorlike sclerosing masses in different organs. Differential diagnosis in orbital IgG4-RD includes majority of conditions, such as thyroid eye disease (TED), sarcoidosis, granulomatosis with polyangiitis, idiopatic orbital inflammation, limphoproliferative diseases and others. A case of IgG4-RD with different organs involvement and complicated differential diagnosis is presented. Read More

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http://dx.doi.org/10.14341/probl10223DOI Listing
November 2019

Spectrum of Posttransplant Lymphoproliferations in NSG Mice and Their Association With EBV Infection After Engraftment of Pediatric Solid Tumors.

Vet Pathol 2020 05 23;57(3):445-456. Epub 2020 Mar 23.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Pediatric patients receiving solid organ transplants may develop lymphoproliferative diseases, including graft-versus-host disease (GvHD) and posttransplant lymphoproliferative diseases (PTLDs). We characterized lesions in 11 clinically ill NOD.Cg-/SzJ (NSG) mice that received pediatric-patient-derived solid tumors (PDXs) and developed immunodeficiency-associated lymphoproliferations comparable to GvHD and PTLDs over a period of 46 to 283 days after implantation. Read More

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http://dx.doi.org/10.1177/0300985820913265DOI Listing

Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report.

Medicine (Baltimore) 2020 Mar;99(12):e19577

Division of Hematology and Medical Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Rationale: The diagnosis of anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (IMT) remains challenging because of their morphological resemblance with spindle cell sarcoma with myofibroblastic characteristics.

Patient Concerns: A 69-year-old female patient presented with loco-regional recurrent IMT several times within 8 years after primary treatment and neck lymph node metastasis 3.5 years after last recurrence. Read More

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http://dx.doi.org/10.1097/MD.0000000000019577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220190PMC

Lymphoproliferative Disease in CVID: a Report of Types and Frequencies from a US Patient Registry.

J Clin Immunol 2020 Apr 17;40(3):524-530. Epub 2020 Mar 17.

Weill Cornell Medicine, New York, NY, USA.

Purpose: Lymphoproliferative disease in common variable immunodeficiency disease (CVID) is heterogeneous in pathogenesis and ranges from non-malignant lymphoid hyperplasia to lymphoma.

Methods: The United States Immunodeficiency Network (USIDNET) patient registry was queried for lymphoproliferative diseases reported in CVID patients. Diagnoses included as possible manifestations of lymphoproliferation included lymphadenopathy, lymphoid hyperplasia, lymphocytic inflammation, lymphocytosis, and gammopathy. Read More

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http://dx.doi.org/10.1007/s10875-020-00769-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310568PMC

Fondazione Italiana Linfomi (FIL) expert consensus on the use of intensity-modulated and image-guided radiotherapy for Hodgkin's lymphoma involving the mediastinum.

Radiat Oncol 2020 Mar 12;15(1):62. Epub 2020 Mar 12.

Azienda Ospedaliera Careggi, Florence, Italy.

Aim: Advances in therapy have resulted in improved cure rates and an increasing number of long-term Hodgkin's lymphoma (HL) survivors. However, radiotherapy (RT)-related late effects are still a significant issue, particularly for younger patients with mediastinal disease (secondary cancers, heart diseases). In many Centers, technological evolution has substantially changed RT planning and delivery. Read More

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http://dx.doi.org/10.1186/s13014-020-01504-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066773PMC

Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis.

Eur Rev Med Pharmacol Sci 2020 Feb;24(4):1899-1912

Department of Colorectal Surgery, Department of Thyroid Breast Surgery, Department of Radiation; Affiliated Nanhua Hospital, University of South China, Hengyang, China.

Objective: Breast cancer (BC) is an intractable cancer with a rising incidence. Small nucleolar RNA host gene 15 (SNHG15) is a novel biomarker of multiple cancers. However, the molecular mechanism of SNHG15 during oncogenesis of BC is still poorly understood. Read More

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http://dx.doi.org/10.26355/eurrev_202002_20368DOI Listing
February 2020

Prevalence of CD8 cytotoxic lymphocytes in human neoplasms.

Cell Oncol (Dordr) 2020 Jun 5;43(3):421-430. Epub 2020 Mar 5.

Institute of Pathology, Martinistraße 52, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.

Purpose: Immune checkpoint inhibitors have recently been approved by the US FDA as first and/or second line therapy in a subset of cancer types. Recent evidence suggests that the quantity of tumor infiltrating lymphocytes (TILs) influences the likelihood of response to immune checkpoint inhibitors. Here, we set out to assess the density of CD8 lymphocytes in a wide range of different cancer types and subtypes. Read More

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http://dx.doi.org/10.1007/s13402-020-00496-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214387PMC

Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1.

Acta Pharm Sin B 2020 Mar 22;10(3):383-398. Epub 2019 Jun 22.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, China.

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Read More

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http://dx.doi.org/10.1016/j.apsb.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049575PMC