4,159 results match your criteria Thyroid Lymphoma

Subclassification of the Bethesda Category III (AUS/FLUS): A Study of thyroid FNA cytology based on ThinPrep slides from the National Cancer Center in China.

Cancer Cytopathol 2021 Jun 17. Epub 2021 Jun 17.

Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The atypia of an undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a heterogeneous category, which includes various cell patterns. The subclassification of AUS/FLUS was suggested in the 2017 TBSRTC. However, the risk of malignancy (ROM) associated with different subgroups remains unresolved. Read More

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MDCT evaluation of synchronous breast carcinoma and other solid malignancies.

Adel El-Badrawy

Breast Dis 2021 Jun 2. Epub 2021 Jun 2.

Radiology Department, Mansoura University Faculty of Medicine, Mansoura, Dakahlya, Egypt.

Background: Multiple primary malignancies are two or more malignancies in an individual without any relationship between the tumors. The development of improved diagnostic techniques, increased survival of cancer patients and the growing life expectancy have all contributed to the increased frequency of this phenomenon.

Objective: The aim of this study is to review the multidetector computed tomography (MDCT) findings of synchronous breast carcinoma and other solid malignancies. Read More

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Summary of the 12 Most Common Cancers in the CancerLinQ Discovery (CLQD) Database.

JCO Clin Cancer Inform 2021 06;5:658-667

CancerLinQ, American Society of Clinical Oncology, Alexandria, VA.

Purpose: In 2014, the ASCO developed CancerLinQ (CLQ), a health technology platform for oncology. The CLQ Discovery (CLQD) database was created to make data available for research and this paper provides a summary of this database.

Methods: This study described the clinical and demographic characteristics of the 12 most common cancers in the CLQD database. Read More

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circRPS28 (hsa_circ_0049055) is a novel contributor for papillary thyroid carcinoma by regulating cell growth and motility via functioning as ceRNA for miR-345-5p to regulate frizzled family receptor 8 (FZD8).

Endocr J 2021 Jun 10. Epub 2021 Jun 10.

Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China.

Circular RNA 40S ribosomal protein S28 (circRPS28; hsa_circ_0049055) is upregulated in papillary thyroid carcinoma (PTC) patients. However, its role remained uncovered in the progression of PTC. Above all, expression of circRPS28 was determined in PTC samples by real-time quantitative PCR and circRPS28 was highly expressed in tumor tissues and cells. Read More

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Cancer risk in tuberculosis patients in a high endemic area.

BMC Cancer 2021 Jun 9;21(1):679. Epub 2021 Jun 9.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, No. 270, Dong'an Road, Xuhui District, Shanghai, 200032, China.

Background: Tuberculosis (TB) may facilitate carcinogenesis. We performed a case-control study of the association between TB and cancer in Xinjiang, a high TB endemic area of China.

Methods: From January 2016 to December 2018, a total of 45,455 patients hospitalized in Xinjiang Cancer Hospital were consecutively enrolled and divided into a malignant tumor group (n = 32,539) and a benign tumor group (n = 12,916). Read More

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Burkitt's Thyroid Lymphoma Revealed in a Pregnant Woman With Acute Dyspnea.

Ear Nose Throat J 2021 Jun 9:1455613211024877. Epub 2021 Jun 9.

Department of Otolaryngology-Head and Neck Surgery, Tahar Sfar Hospital, Mahdia, Tunisia.

Extraganglionic Burkitt's lymphoma is rare. Primary thyroid localization accounts for 1% to 5% of malignant tumors of the thyroid gland. The association of Burkitt's lymphoma and pregnancy is even rarer. Read More

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FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment.

J Cancer 2021 13;12(13):4109-4120. Epub 2021 May 13.

Special Key Laboratory of Oral Disease Research, Higher Education Institution in Guizhou Province, School of Stomatology, Zunyi Medical University, Zunyi 563006, China.

Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation. FUT8 and/or core fucosylated proteins are frequently upregulated in liver, lung, colorectal, pancreas, prostate,breast, oral cavity, oesophagus, and thyroid tumours, diffuse large B-cell lymphoma, ependymoma, medulloblastoma and glioblastoma multiforme and downregulated in gastric cancer. Read More

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Application of Color Doppler Ultrasound to Evaluate Chemotherapeutic Effect on Primary Thyroid Lymphoma.

J Med Ultrasound 2021 Jan-Mar;29(1):60-63. Epub 2020 May 25.

Division of Hematology/Oncology, Department of Medicine, Tri-Service General Hospital, National Defence Medical Center, Taipei City, Taiwan.

Primary thyroid lymphoma (PTL) is a rare disease which responds well to rituximab-based chemotherapy. Here, we describe a case who was diagnosed through core needle biopsy as having diffuse large B-cell lymphoma in the right lobe of thyroid gland. Positron emission tomography computed tomography (PET-CT) revealed no other foci of hot spots, so PTL was considered. Read More

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Thymic Carcinomas and Second Malignancies: A Single-Center Review.

Cancers (Basel) 2021 May 19;13(10). Epub 2021 May 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Thymic carcinomas account for less than 0.01% of new cancer diagnoses annually and are more aggressive than thymomas. Autoimmune disorders have been associated with thymomas and only recently with thymic carcinomas. Read More

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The Orphan Nuclear Receptor Gene NR0B2 Is a Favorite Prognosis Factor Modulated by Multiple Cellular Signal Pathways in Human Liver Cancers.

Front Oncol 2021 14;11:691199. Epub 2021 May 14.

Department of Urology, The University of Kansas Medical Center, Kansas City, KS, United States.

Background: Liver cancer is a leading cause of cancer death worldwide, and novel prognostic factor is needed for early detection and therapeutic responsiveness monitoring. The orphan nuclear receptor NR0B2 was reported to suppress liver cancer development in a mouse model, and its expression levels were reduced in liver cancer tissues and cell lines due to hypermethylation within its promoter region. However, it is not clear if NR0B2 expression is associated with cancer survival or disease progression and how NR0B2 gene expression is regulated at the molecular level. Read More

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Case Report of an Unusual Tumor in an Adult With a TP53 Germline Mutation.

Clin Lymphoma Myeloma Leuk 2020 Dec 31. Epub 2020 Dec 31.

Department of Hematology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

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December 2020

Primary thyroid lymphoma: survival analysis of SEER database (1995-2016).

Leuk Lymphoma 2021 May 27:1-4. Epub 2021 May 27.

Department of Medicine, Division of Hematology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.

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Thyroid MALT lymphoma: self-harm to gain potential T-cell help.

Leukemia 2021 May 21. Epub 2021 May 21.

Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.

The development of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is driven by chronic inflammatory responses and acquired genetic changes. To investigate its genetic bases, we performed targeted sequencing of 93 genes in 131 MALT lymphomas including 76 from the thyroid. We found frequent deleterious mutations of TET2 (86%), CD274 (53%), TNFRSF14 (53%), and TNFAIP3 (30%) in thyroid MALT lymphoma. Read More

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Inborn error of immunity as the cause of recurrent pericarditis.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Paul Stradins Clinical University Hospital, Riga, Latvia

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by a pyrin dysfunction, leading to uncontrolled interleukin-1 production that triggers the attacks. Here we report a case of a 36-year-old female patient repeatedly admitted to the cardiology ward with recurrent episodes of pericarditis, with intervals of 1 and 2 months between the episodes. During the attacks, chest pain and fever were the only symptoms. Read More

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Papillary thyroid carcinoma in a 5-year old child, mimicking lymphoma in presentation.

Avicenna J Med 2021 Apr-Jun;11(2):103-106. Epub 2021 Apr 19.

Department of Radiology and Nuclear Medicine, The University of Jordan, Amman, Jordan.

Thyroid cancer is very rare in children and papillary thyroid carcinoma (PTC) represents the most common type. Patients are frequently in the second decade of life and complain of painless enlargement of the gland. Pediatric PTC has unique clinicopathologic characteristics that make it different from the adult counterpart. Read More

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Nature and outcome of malignant goiter: a revisit.

Pan Afr Med J 2021 23;38:204. Epub 2021 Feb 23.

Division of General Surgery, Department of Surgery, College of Medicine, King Faisal University, Riyadh, Kingdom of Saudi Arabia.

Introduction: the aim of this retrospective study is to review patients with malignant goiter, as regards their nature, demographic characterization, clinical presentation and preoperative histopathological data.

Methods: the study focused on a period of 4 years from December 2015 to January 2019. Patients´ demographic data, clinical presentation, Intra-operative findings, Pre and postoperative histopathological staging and grading were all recorded. Read More

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Adherence to Active Surveillance and Clinical Outcomes in Patients with Indeterminate Thyroid Nodules Not Referred for Thyroidectomy.

Eur Thyroid J 2021 Apr 6;10(2):168-173. Epub 2020 Aug 6.

Endocrine Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.

Objective: Outcomes of patients with cytologically indeterminate thyroid nodules not referred for thyroidectomy have hardly been investigated. We previously reported outcomes of 322 patients with thyroid nodules classified according to the Bethesda System of Reporting Thyroid Cytology (BSRTC) as indeterminate (B3/B4), of whom 123 (38.2%) underwent thyroidectomy. Read More

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A Rare Case of Thyroid Carcinoma Showing Thymus-Like Differentiation in a Young Adult.

Case Rep Oncol 2021 Jan-Apr;14(1):671-675. Epub 2021 Apr 12.

Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.

Thyroid carcinoma showing thymus-like differentiation (CASTLE) is thought to originate from ectopic thymic tissue or remnants of the developing thymus within or adjacent to the thyroid. This case report describes a mass located on the left thyroid of a 28-year-old man. Fine-needle aspiration cytology revealed a number of lymphoid cells without atypia that were similar to those seen in a malignant lymphoma of the thyroid, and surgery was performed. Read More

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Massive lateral neck mass: aberrant ectopic thyroid malignancy.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Pathology, Nitte University K S Hegde Medical Academy, Mangalore, Karnataka, India.

Lateral aberrant ectopic thyroid is very rare, comprising only 1%-3% of all the ectopic thyroid tissue. Clinically, these lesions are mistaken for lymph node swelling or metastatic tumour. Primary carcinoma in lateral aberrant ectopic thyroid with normal active native thyroid is very uncommon. Read More

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CXCL1 Clone Evolution Induced by the HDAC Inhibitor Belinostat Might Be a Favorable Prognostic Indicator in Triple-Negative Breast Cancer.

Biomed Res Int 2021 17;2021:5089371. Epub 2021 Apr 17.

Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, China.

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer due to its lack of treatment options. Patients with TNBC frequently develop resistance to chemotherapy. As epigenetic-based antineoplastic drugs, histone deacetylase inhibitors (HDACis) have achieved particular efficacy in lymphoma but are less efficacious in solid tumors, and the resistance mechanism remains poorly understood. Read More

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The Prognostic Value of PERK in Cancer and Its Relationship With Immune Cell Infiltration.

Front Mol Biosci 2021 16;8:648752. Epub 2021 Apr 16.

Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, Key Laboratory of Biomedicine in Gene Diseases, Health of Anhui Higher Education Institutes, Anhui Normal University, Wuhu, China.

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a type I transmembrane protein that functions as an endoplasmic reticulum (ER) stress sensor to regulate global protein synthesis. Recent research studies suggest that PERK, as an important receptor protein of unfolded protein response, is involved in the pathogenesis of many cancers. This study aimed to investigate PERK expression and its relationship with prognosis in pan-cancer and attempted to explore the relevant mechanism of PERK involved in the regulation of cancer pathogenesis. Read More

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The relationship among primary anatomic subsite and risk and distribution of second malignant neoplasms in patients with stage I/II diffuse large B-cell lymphoma: An analysis of the surveillance, epidemiology, and end results database.

Transl Oncol 2021 Jul 28;14(7):101106. Epub 2021 Apr 28.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, China.

Background: Recent studies have reported that diffuse large B-cell lymphoma (DLBCL) involving different primary extranodal sites have distinct clinicopathological characteristics and prognosis. However, the risk of secondary malignant neoplasms (SMNs) in DLBCL survivors with different primary extranodal sites are unknown.

Methods: A total of 40,714 patients diagnosed with stage I/II DLBCL were included from the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2015. Read More

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Solid Organ Transplantation and Survival among Individuals with a History of Cancer.

Cancer Epidemiol Biomarkers Prev 2021 Apr 29. Epub 2021 Apr 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Background: The success of immunotherapy highlights a possible role for immunity in controlling cancer during remission for patients with cancer in the general population. A prior cancer diagnosis is common among solid organ transplant candidates, and immunosuppressive medications administered to transplant recipients may increase recurrence risk.

Methods: Using linked data from the United States solid organ transplant registry and 13 cancer registries, we compared overall and cancer-specific survival among patients with cancer who did versus did not receive subsequent transplantation. Read More

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Clinical Perspectives of Theranostics.

Molecules 2021 Apr 13;26(8). Epub 2021 Apr 13.

Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Theranostics is a precision medicine which integrates diagnostic nuclear medicine and radionuclide therapy for various cancers throughout body using suitable tracers and treatment that target specific biological pathways or receptors. This review covers traditional theranostics for thyroid cancer and pheochromocytoma with radioiodine compounds. In addition, recent theranostics of radioimmunotherapy for non-Hodgkin lymphoma, and treatment of bone metastasis using bone seeking radiopharmaceuticals are described. Read More

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Anemia May Increase the Overall Risk of Cancer: Findings from a Cohort Study with a 12-Year Follow-up Period in South Korea.

Cancer Epidemiol Biomarkers Prev 2021 Apr 20. Epub 2021 Apr 20.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: No previous study has assessed cancer risk in individuals with anemia diagnosed based on hemoglobin levels. Thus, we aimed to investigate whether anemia increases the risk of cancer.

Methods: Adult individuals who underwent a standardized medical examination during 2002 and 2003 in South Korea were included, and their cancer status was evaluated between January 2004 and December 2015 (12 years) as a primary endpoint. Read More

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Risk and survival of second primary malignancies following diagnosis of gastric mucosa-associated lymphoid tissue lymphomas: A population-based study.

Curr Probl Cancer 2021 Apr 2:100735. Epub 2021 Apr 2.

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. Electronic address:

Whether gastric mucosa-associated lymphoid tissue lymphoma (GML) is associated with a higher risk of second primary malignancy (SPM) remains controversial. This study aimed to evaluate the detailed risk of SPM and its prognosis in patients with GML based on a large population-based cohort. The Surveillance, Epidemiology, and End Results database was searched to identify patients who were diagnosed with GML during 2000-2014. Read More

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Ga-FAPI PET/CT imaging in a patient with primary thyroid lymphoma.

Endocrine 2021 Jul 16;73(1):230-231. Epub 2021 Apr 16.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, P.R. China.

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Incidence and prognostic factors of primary thyroid lymphoma and construction of prognostic models for post-chemotherapy and postoperative patients: a population-based study.

BMC Endocr Disord 2021 Apr 13;21(1):68. Epub 2021 Apr 13.

Department of Pathology, Wannan Medical College, Wenchang West Road 22, Wuhu, Anhui, China.

Background: Primary thyroid lymphoma (PTL) is a rare thyroid malignancy, there are few large sample studies on PTL and no standardized treatment regimen has been established due to the rarity. The aims of this study were to explore the incidence and prognostic factors of PTL and construct visual prognostic prediction models for post-chemotherapy and postoperative patients.

Methods: The incidence of PTL in 1975-2017 was extracted from the US Surveillance, Epidemiology, and End Results (SEER) database, then assessed using joinpoint regression software. Read More

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Bcl-2-negative IGH-BCL2 translocation-negative follicular lymphoma of the thyroid differs genetically and epigenetically from Bcl-2-positive IGH-BCL2 translocation-positive follicular lymphoma.

Histopathology 2021 Apr 7. Epub 2021 Apr 7.

Department of Pathology, Sakai City Medical Center, 1-1-1 Ebaraji-cho, Nishi-ku, Sakai, Osaka, 593-8304, Japan.

Aims: Follicular lymphoma (FL), comprising a minor subset of primary thyroid lymphomas, is divided into two groups based on Bcl-2 expression and IGH-BCL2 translocation. The clinicopathological features exhibited by Bcl-2-negative IGH-BCL2 translocation-negative FL of the thyroid (Bcl-2 /IGH-BCL2 tFL) are different from those of conventional FL; however, its lymphomagenesis remains unclear. Here, we collected samples from seven patients with Bcl-2 /IGH-BCL2 tFL to investigate their epigenetic and genetic aberrations. Read More

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Primary Extra-Nodal DLBCL of Glands: Our Experiences outside Guidelines of Treatment.

Healthcare (Basel) 2021 Mar 5;9(3). Epub 2021 Mar 5.

Division of Pathology, Department of Mental Health and Preventive, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Lymphomas usually involve lymph nodes and other lymphoid tissues, but sometimes occur in non-lymphoid organs, called extra-nodal sites. Primary diffuse extra-lymph node large B-cell lymphoma (DLBCL) of the thyroid and parotid gland have been observed rarely. According to the most accredited guidelines, primary extra-nodal DLBCL of the parotid and thyroid glands should be treated with three cycles of R-CHOP followed by radiotherapy of the involved site (ISRT). Read More

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