10,269 results match your criteria Thyroid Follicular Carcinoma

Follicular Epithelial Dysplasia as Hashimoto Thyroiditis-Related Atypia: a Series of 91 Specimens.

Endocr Pathol 2021 May 15. Epub 2021 May 15.

Department of Biology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Follicular epithelial dysplasia (FED) is described as Hashimoto thyroiditis-related atypia and is thought to be a possible precancerous lesion. Dysplasia as an interface between normal state and carcinoma is described in a wide range of diseases and carcinogenesis chains. On the other hand, inflammation-related atypia and cancerogenesis is also widely studied. Read More

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Case Report: Bilateral Renal Cell Carcinoma With Different Histological and Morphological Features, Clear Cell and Cystic Thyroid-Like Follicular Subtype.

Front Oncol 2021 26;11:659706. Epub 2021 Apr 26.

Department of Pathology, The First Hospital of Jilin University, Changchun, China.

Thyroid-like follicular renal cell carcinoma is a rare subtype of renal cell carcinoma that has only been recently recognized, as most cases involve a solid tumor in one kidney. In this study, we report a rare case of bilateral renal cell carcinoma wherein the tumor in the left kidney was diagnosed as clear cell carcinoma, while the tumor in right kidney as thyroid-like follicular renal cell carcinoma. The difference between this case and the ones described in previous reports is that thyroid-like follicular renal cell carcinoma showed cystic changes on imaging. Read More

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Non-functioning oxyphilic parathyroid carcinoma: a case report.

Surg Case Rep 2021 May 12;7(1):119. Epub 2021 May 12.

Department of Pathology, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama-shi, Kanagawa, Tokyo, 224-8503, Japan.

Background: Non-functioning parathyroid carcinoma is an extremely rare malignancy among endocrine tumors. We report a case in which non-functional oxyphilic parathyroid carcinoma was diagnosed from clinical symptoms and pathological diagnosis.

Case Presentation: The patient was a 42-year-old man with no medical or family history of note. Read More

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Molecular pathogenesis of pediatric thyroid carcinoma.

J Radiat Res 2021 May;62(Supplement_1):i71-i77

Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

There has been little understanding of the molecular pathogenesis of pediatric thyroid cancers. Most of them are histologically classified as papillary thyroid carcinoma (PTC). Ionizing radiation is the most important environmental factor to induce PTC, especially in children. Read More

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DNA repair proteins may differentiate papillary thyroid cancer from chronic lymphocytic thyroiditis and nodular colloidal goiter.

Sci Rep 2021 May 11;11(1):9932. Epub 2021 May 11.

Department of Endocrinology and Metabolism, Fırat University Medical School, Elazığ, Turkey.

Malignant thyroid lesions are the most common malignancy of the endocrine glands with increasing rates in the last two decades. Papillary thyroid cancer is the most common thyroid malignancy. In our study, we aimed to quantitatively evaluate the levels of DNA repair proteins MSH2, MLH1, MGMT, which are representative blocks of patients diagnosed with papillary carcinoma, chronic thyroiditis, or colloidal goiter. Read More

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Papillary Thyroid Microcarcinomas: Does Sub-typing Predict Aggressive Clinical Behavior?

Hum Pathol 2021 May 7. Epub 2021 May 7.

Hospital of the University of Pennsylvania, 6 Founders 3400 Spruce Street Philadelphia, PA 19104, United States.

The most common malignant neoplasm affecting the thyroid gland is papillary thyroid carcinoma (PTC). PTC can demonstrate a number of morphologic variants including but not limited to classic, follicular, and tall cell. Each of these morphologic sub-types carry distinct clinical characteristics such that certain variants, like tall cell, behave more aggressively than others. Read More

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HBME1 and CK19 expression in non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) vs other follicular patterned thyroid lesions.

World J Surg Oncol 2021 May 8;19(1):143. Epub 2021 May 8.

Department of Pathology, University of New Mexico School of Medicine, MSC08 4640, 1 University of New Mexico, Albuquerque, NM, 87131, USA.

Background: Thyroid neoplasms with follicular architecture can have overlapping morphologic features and pose diagnostic confusion among pathologists. Various immunohistochemical stains have been investigated as potential diagnostic markers for PTC, among which HBME1 and CK19 have gained popularity. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) poses similar diagnostic challenges with interobserver variability and is often misdiagnosed as adenomatoid nodule or follicular adenoma. Read More

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NRAS Q61R Immunohistochemical Staining in Thyroid Pathology: Sensitivity, Specificity and Utility.

Histopathology 2021 May 7. Epub 2021 May 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: The diagnosis of thyroid neoplasms relies on the demonstration of histologic parameters that can be focal and prone to subjective interpretation. We evaluated the utility of NRAS Q61R immunohistochemistry (IHC) in the diagnosis of thyroid lesions after determining its specificity and sensitivity as a surrogate marker for RAS Q61R mutation.

Design: NRAS Q61R IHC was performed on 282 primary or metastatic thyroid lesions from 256 patients. Read More

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Weathering the Storm: Thyroid Storm Precipitated by Radioiodine Contrast in Metastatic Thyroid Carcinoma.

Cureus 2021 Mar 31;13(3):e14219. Epub 2021 Mar 31.

Department of Pulmonary and Critical Care Medicine, Detroit Medical Center Sinai-Grace Hospital, Detroit, USA.

Thyroid storm is an extremely rare yet life-threatening medical emergency. It results from the decompensation of undiagnosed or undertreated hyperthyroidism in the presence of an acute stressor such as trauma to the thyroid, infections, acute iodine load, withdrawal from the antithyroid medication, or surgical procedures (including thyroid surgery). Clinical features of thyroid storm include hyperthermia, tachycardia, respiratory distress, gastrointestinal and hepatic symptoms, and central nervous system dysfunction. Read More

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Genetics of Familial Non-Medullary Thyroid Carcinoma (FNMTC).

Cancers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

Unit of Medical Genetics, Department of Medical and Surgical Sciences; University of Bologna, 40138 Bologna, Italy.

Non-medullary thyroid carcinoma (NMTC) is the most frequent endocrine tumor and originates from the follicular epithelial cells of the thyroid. Familial NMTC (FNMTC) has been defined in pedigrees where two or more first-degree relatives of the patient present the disease in absence of other predisposing environmental factors. Compared to sporadic cases, FNMTCs are often multifocal, recurring more frequently and showing an early age at onset with a worse outcome. Read More

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Clinicopathological Characteristics and Prognosis of Poorly Differentiated Thyroid Carcinoma Diagnosed According to the Turin Criteria.

Endocr Pract 2021 May 15;27(5):401-407. Epub 2020 Dec 15.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China. Electronic address:

Objective: Poorly differentiated thyroid carcinoma (PDTC) is the primary cause of death in patients with nonanaplastic follicular cell-derived thyroid carcinoma. We purposed to identify the clinical and pathological characteristics of PDTC and their relationship with prognosis.

Methods: A retrospective analysis was conducted on patients diagnosed with PDTC at our institution from 2010 to 2018. Read More

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In Vivo Imaging of Thyroid Cancer with Tc-TR1401 and Tc-TR1402: A Comparison Study in Dogs.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00161 Rome, Italy.

Differentiated thyroid cancer (DTC) cells may lose NIS expression and iodine uptake, but usually express TSH receptors (TSHR). Therefore, the aim of our study was to compare two radiolabeled superagonist TSH analogues for DTC imaging. These analogues (namely TR1401 and TR1402) have a higher TSHR binding affinity than recombinant human TSH (Thyrogen). Read More

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Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis.

Cancers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Department of Molecular Endocrinology, Institute of Endocrinology, 11694 Prague, Czech Republic.

Chromosomal rearrangements of genes are oncogenic driver mutations in thyroid cancer (TC). This study aimed to identify fusion-positive thyroid tumors and to correlate them with clinical and pathological data and determine their prognostic significance. The cohort consisted of 989 different TC samples. Read More

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Occurrence of sporadic medullary thyroid carcinoma in Graves' disease in association with a RET proto-oncogene mutation.

Acta Clin Belg 2021 Apr 29:1-4. Epub 2021 Apr 29.

Unit of Digestive, Endocrine and General Surgery, Department of Surgery, Université Catholique de Louvain, Yvoir, Belgium.

: Graves' disease may be associated with thyroid cancer, particularly differentiated thyroid cancer. Medullary thyroid cancer (MTC) is less common. The occurrence of sporadic MTC in Graves' disease in the presence of a RET proto-oncogene has never been reported. Read More

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Case 13-2021: A Newborn Girl with a Neck Mass.

N Engl J Med 2021 Apr;384(17):1647-1655

From the Departments of Pediatrics (D.K., K.A.S.), Radiology (R.S.), and Pathology (P.M.S.), Massachusetts General Hospital, and the Departments of Pediatrics (D.K., K.A.S.), Radiology (R.S.), and Pathology (P.M.S.), Harvard Medical School - both in Boston.

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Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP).

Ther Adv Endocrinol Metab 2021 12;12:20420188211000500. Epub 2021 Apr 12.

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.

Background: Criteria for the preoperative diagnosis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) have not yet been confirmed. This study aimed to analyze differences in clinicopathological characteristics between follicular variant of papillary thyroid carcinoma (FVPTC) subtypes to determine which parameters are relevant in differentiating NIFTP from other variants.

Methods: We retrospectively analyzed the records of 199 patients with a preoperative diagnosis of FVPTC who underwent thyroid surgery at Seoul St. Read More

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Diagnostic Utility of p62 Expression in Intranuclear Inclusions in Thyroid Core Needle Biopsy Specimens.

In Vivo 2021 May-Jun;35(3):1769-1775

Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;

Background/aim: Core needle biopsy (CNB) has been widely used as an alternative method to ultrasound-guided fine-needle aspiration cytology for histological diagnosis of thyroid specimens. However, nuclear artifactual vacuoles (NuVas) produced during tissue processing can be very difficult and sometimes impossible to distinguish from intranuclear inclusions (NuIns). P62 is an autophagy receptor that recognizes, targets, and eliminates toxic cellular materials during autophagy. Read More

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January 2021

[The Therapy of Malignant Thyroid Disease from ENT-Perspective].

Laryngorhinootologie 2021 Apr 27. Epub 2021 Apr 27.

Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany.

Introduction:  Malignant tumours of the thyroid gland show a rising incidence. As in the ENT-department Bad Hersfeld the management of thyroid disorders has been in focus for a longer period, we want to share our experiences in this field.

Material And Methods:  The investigation started in the year of 2014 till July 2020. Read More

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Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.

Bioengineered 2021 Dec;12(1):1299-1310

Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Differentiated thyroid carcinoma (DTC) is one of the most common malignant tumors. Increasing evidence indicates that centromere protein K(CENPK) may play a key role in promoting carcinogenesis. The expression, biological functions, and clinical significance of CENPK in DTC are still unclear. Read More

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December 2021

Impact of molecular testing on detecting mimics of oncocytic neoplasms in thyroid fine-needle aspirates diagnosed as follicular neoplasm of Hürthle cell (oncocytic) type.

Cancer Cytopathol 2021 Apr 26. Epub 2021 Apr 26.

Department of Pathology, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania.

Background: Some thyroid nodules cytologically presenting as follicular neoplasm, Hürthle cell (Oncocytic) type (FNHCT), are not oncocytic tumors and represent autonomously functioning thyroid nodules (AFTNs) with TSHR, GNAS, and EZH1 mutations or oncocytic metaplasia. A to be defined subset of FNHCT harbors genome haploidisation-type DNA copy number alterations (GH-CNA). Molecular profiling of FNHCT may distinguish oncocytic neoplasms from its mimics. Read More

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Pathological and Immunohistochemical Characterization of Thyroid Neoplasms in Cats.

J Comp Pathol 2021 Apr 2;184:44-55. Epub 2021 Mar 2.

Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

There are few pathological and immunohistochemical descriptions of thyroid neoplasms in cats. We investigated neoplasms of the thyroid in 31 cats (average age 15.6 years) in Southern Brazil. Read More

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Ultrasound criteria (EU-TIRADS) to identify thyroid nodule malignancy risk in adolescents. Correlation with cyto-histological findings.

Endocrinol Diabetes Nutr 2021 Apr 19. Epub 2021 Apr 19.

Sección Endocrinología Pediátrica, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, CIBER de Enfermedades Raras (CIBERER) ISCIII, EndoERN, Barcelona, España.

Introduction: Thyroid nodule (TN) harboring a thyroid carcinoma are more common in pediatric than adult patients. In pediatric population, the evaluation of a TN should require specific pediatric tools for its diagnostic and therapeutic management. High-resolution ultrasonography and cytological evaluation after fine-needle aspiration biopsy (FNAB) remain the cornerstones of evaluation of TN. Read More

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Are molecular tests necessary to diagnose NIFTP?

Genes Cancer 2021 15;12:39-50. Epub 2021 Mar 15.

Endocrinology Clinic of Holycross Cancer Centre, Kielce, Poland.

In 2016, encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). In 2018 the criteria for NIFTP were widened by the inclusion of the complete lack of papillae. Secondary criteria, which include molecular examination, are helpful but not required for NIFTP diagnose. Read More

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The role of ThyroSeq V3 testing in the management of patients with indeterminate thyroid nodules on fine needle aspiration.

Diagn Cytopathol 2021 Apr 17. Epub 2021 Apr 17.

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Background: The multigene genomic classifier ThyroSeq V3 has proven to be an effective triage modality in the management of indeterminate thyroid nodules. This study reports on the clinical management of patients with indeterminate thyroid nodules.

Methods: ThyroSeq V3 testing at our institution was implemented April 1, 2019. Read More

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Progress in Treating Advanced Thyroid Cancers in the Era of Targeted Therapy.

Thyroid 2021 Apr 16. Epub 2021 Apr 16.

Massachusetts General Hospital, 55 Fruit St, Boston, Massachusetts, United States, 02114;

Background: Thyroid cancer is a common malignancy whose detection has increased significantly in past decades. Most of the increased incidence is due to detection of early well-differentiated thyroid cancer, but the incidence of more advanced thyroid cancers has increased as well. Recent methodological advancements have allowed for a deep understanding of the molecular underpinnings of the various types of thyroid cancer. Read More

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Disease-free Survival of Patients with Differentiated Thyroid Cancer: A Study from a Tertiary Center in Oman.

Oman Med J 2021 Mar 31;36(2):e246. Epub 2021 Mar 31.

Division of Endocrinology, Royal Hospital, Muscat, Oman.

Objectives: As with global trends, the prevalence of differentiated thyroid cancer (DTC) has increased in recent years in Oman. However, to the best of our knowledge, no local studies have yet been published evaluating the prognosis of DTC cases in Oman. This study aimed to assess disease-free survival (DFS) and prognostic factors related to DTC among Omani patients attending a tertiary care center. Read More

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Outcomes following I-131 treatment with cumulative dose exceeding or equal to 600 mCi in differentiated thyroid carcinoma patients.

World J Nucl Med 2021 Jan-Mar;20(1):54-60. Epub 2020 Aug 22.

Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

To evaluate treatment outcomes following radioactive iodine (RAI) treatment with a cumulative dose of ≥≥600 mCi in differentiated thyroid carcinoma (DTC) patients, a retrospective review of medical records was done in 176 DTC patients with a cumulative dose of ≥600 mCi from January 1993 to December 2013. All patients were followed up for at least 2 years after receiving 600 mCi of I-131 treatment. Remission criteria were no clinical and imaging evidence of disease and low serum thyroglobulin levels during thyroid-stimulating hormone suppression of <0. Read More

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Papillary and Medullary Thyroid Carcinomas Presenting as Collision Tumors: A Case Series of 21 Cases at a Tertiary Care Cancer Center.

Head Neck Pathol 2021 Apr 11. Epub 2021 Apr 11.

Homi Bhabha National Institute, Mumbai, 400012, India.

Collision tumor is the occurrence of two histologically and morphologically distinct tumors within the same organ with no histological admixture. Collision tumors of the thyroid are extremely rare constituting < 1% of all thyroid tumors. Clinical profiles and pathological features of Medullary thyroid carcinoma (MTC) and Papillary thyroid carcinoma (PTC) presenting as Collision tumors of thyroid, diagnosed between 2009 and 2019, at a tertiary care cancer center were retrospectively analyzed. Read More

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Clinical characteristics and survival outcomes of malignant struma ovarii confined to the ovary.

BMC Cancer 2021 Apr 9;21(1):383. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China.

Background: Malignant struma ovarii (MSO) is a unique type of ovarian malignancy that data on the survival outcome is limited and management strategy remains controversial due to its extreme rarity.

Methods: To investigate the clinical characteristics and treatment options in patients with MSO confined to the ovary, while also evaluating the recurrent-free survival (RFS) and overall survival (OS) rate in this population, a retrospective study was conducted. One hundred twenty-five cases of MSO confined to the ovary were enrolled and their clinical characteristics, treatment strategies, and results of follow-up were analyzed. Read More

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