Search Our Scientific Publications & Authors

J Clin Endocrinol Metab 2022 May 12. Epub 2022 May 12.

Division of Endocrinology, Department of Medicine, University of California, San Francisco.

Context: Patients with radioactive iodine (RAI) refractory metastatic differentiated thyroid cancer (DTC) have poor prognosis. Early identification of RAI refractoriness may improve care.

Objective: To characterize DTC patients with distant metastases (DM) at diagnosis who presented with non-iodine avid disease. Read More

Cureus 2022 Apr 10;14(4):e24006. Epub 2022 Apr 10.

Department of General Surgery, Salmaniya Medical Complex, Manama, BHR.

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical manifestations. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a rare variant of papillary thyroid cancer. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Apr;57(4):531-534

Department of Head and Neck Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.

Endocr Pathol 2022 May 6. Epub 2022 May 6.

Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, via Roma 67, 56100, Pisa, Italy.

Eur Thyroid J 2022 Apr 1. Epub 2022 Apr 1.

X Zhu, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.

Objective: The data regarding the mutation landscape in Chinese patients with thyroid cancer are limited. The diagnostic performance of thyroid nodules by fine-needle aspiration (FNA) cytology needs optimization, especially in indeterminate nodules.

Methods: A total of 1039 FNA and surgical resection samples tested using the targeted multigene NGS panel were retrospectively collected. Read More

Front Immunol 2022 20;13:840811. Epub 2022 Apr 20.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Background: The tumor microenvironment (TME) plays a pivotal role in cancer progression in papillary thyroid carcinoma (PTC), yet the composition and the phenotype of cells within the TME in bilateral PTC are poorly understood.

Methods: We performed unbiased transcriptome-wide single-cell RNA sequencing (scRNA-seq) analysis on 29,561 cells from 3 pairs of bilateral PTC and 1 non-tumor thyroid sample. The results of the analysis were validated by a large-scale bulk transcriptomic dataset deposited in The Cancer Genome Atlas (TCGA) database. Read More

Ann Surg Oncol 2022 May 5. Epub 2022 May 5.

Department of Surgery, Ito Hospital, Shibuya-ku, Tokyo, Japan.

Appl Immunohistochem Mol Morphol 2022 May-Jun 01;30(5):389-396. Epub 2022 Mar 1.

Department of Hospital Pathology.

Loss of CD56 expression has been regarded as a diagnostic marker of papillary thyroid carcinoma (PTC). However, certain variants of PTC can aberrantly express CD56. Using a digital image analysis tool, we evaluated H-scores of CD56 immunostaining in 216 thyroid tumors. Read More

Cureus 2022 Apr 1;14(4):e23742. Epub 2022 Apr 1.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Jeddah, SAU.

Renal cell carcinoma (RCC) is the most common renal malignancy. It has a variable clinical course with metastasis to unusual sites occurring months to years after the initial diagnosis. However, metastasis can also be the first presentation of RCC. Read More

J Healthc Eng 2022 25;2022:3035073. Epub 2022 Apr 25.

Department of Pathology, School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Background: Gastric adenocarcinoma (GAD) is one of the most common tumors in the world and the prognosis is still very poor.

Objective: We sought to identify reliable prognostic biomarkers for the progression of GAD and the sensitivity to drug therapy.

Method: The RNA sequencing data of GAD was downloaded from the Cancer Genome Atlas (TCGA) database and used for analysis. Read More

Endocr J 2022 Apr 29. Epub 2022 Apr 29.

Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan.

The World Health Organization (WHO) classifies follicular thyroid carcinoma (FTC) into three categories: minimally invasive (mFTC), encapsulated angioinvasive (eaFTC), and widely invasive (wFTC). This study investigated whether this classification is appropriate. We enrolled 523 patients who underwent initial surgery at Kuma Hospital between 1998 and 2015 and were diagnosed with FTC. Read More

Cir Esp (Engl Ed) 2022 Apr 28. Epub 2022 Apr 28.

Unidad de Cirugía Endocrina, Departamento de Cirugía General y Aparato Digestivo, Hospital Universitario Virgen de Valme, Sevilla, Spain.

Histopathology 2022 Apr 26. Epub 2022 Apr 26.

Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, US.

Aims: The definition of papillary thyroid carcinoma, solid variant (PTC-SV) varies from >50% to 100% of solid/trabecular/insular growth (STI). We aimed to identify prognostic factors and to establish an appropriate STI cutoff for PTC-SV in this multi-institutional study of 156 PTCs with STI.

Results: Nodal metastases were seen in 18% and were associated with higher percentage of papillary and STI. Read More

J Digit Imaging 2022 Apr 26. Epub 2022 Apr 26.

Radiotherapy Center, Wenzhou Medical University First Affiliated Hospital, Wenzhou, 32500, China.

Noninvasive differentiating thyroid follicular adenoma from carcinoma preoperatively is of great clinical value to decrease the risks resulted from excessive surgery for patients with follicular neoplasm. The purpose of this study is to investigate the accuracy of ultrasound radiomics features integrating with ultrasound features in the differentiation between thyroid follicular carcinoma and adenoma. A total of 129 patients diagnosed as thyroid follicular neoplasm with pathologically confirmed follicular adenoma and carcinoma were enrolled and analyzed retrospectively. Read More

Int J Surg Pathol 2022 Apr 24:10668969221095170. Epub 2022 Apr 24.

Department of Pathology, 12334University of Texas Southwestern Medical Center, Dallas, TX, USA.

The spindle cell/sclerosing subtype of rhabdomyosarcoma is classified based on genetic features into the three categories of -mutated, gene fusion-driven, and a subset without a currently identified genetic driver event. The gene fusion-driven spindle cell/sclerosing rhabdomyosarcomas are heterogenous and characterized by increasing numbers of gene fusions, the most common gene partners being , , and . Here we report a spindle cell/sclerosing rhabdomyosarcoma that arose in the orbit of a 4-year-old male. Read More

Oxf Med Case Reports 2022 Apr 19;2022(4):omac041. Epub 2022 Apr 19.

Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

We present a female patient with autonomously functioning thyroid nodule (AFTN) and coexisting follicular thyroid carcinoma (FTC). At age 21, a left thyroid nodule was incidentally detected on computer tomography (CT) scan. At age 33, she had cervical compression and CT showed the left thyroid nodule had increased in size from 13 to 27 mm. Read More

Oxid Med Cell Longev 2022 15;2022:9982449. Epub 2022 Mar 15.

Zhengjiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Mitochondrial DNA (mtDNA) mutations have been identified in various human cancers, including thyroid cancer. However, the relationship between mtDNA and thyroid cancer remains unclear. Previous studies by others and us strongly suggested that mtDNA mutations in complex I may participate in thyroid cancer processes according to sequencing results of thyroid cancer tissue, although the associated pathogenic processes remain unknown. Read More

Indian J Surg Oncol 2022 Mar 29;13(1):81-86. Epub 2021 Oct 29.

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.

The real-world patterns of TKI use in differentiated thyroid cancer (DTC) are largely governed by the accessibility and financial feasibility of the patient with more sorafenib use compared to lenvatinib. There are limited data available on the toxicity profile, safety and tolerance of sorafenib and lenvatinib in DTC. Hence, we audited our practice on DTC. Read More

Diagnostics (Basel) 2022 Mar 30;12(4). Epub 2022 Mar 30.

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

A myriad of histological variants of papillary thyroid carcinoma (PTC) have been described, some of which can be diagnostically challenging due to their rarity and overlapping histomorphology with other entities. One of the scarce and poorly characterised variants is PTC with spindle cell metaplasia, of which fewer than 20 cases have been reported in the literature hitherto. Our patient was a 51-year-old woman with a four-month history of painless, gradually enlarging neck swelling. Read More

Ann R Coll Surg Engl 2022 Apr 21. Epub 2022 Apr 21.

Oxford University Hospitals NHS Foundation Trust, UK.

Background: Fine-needle aspiration cytology (FNAC) is an integral part of thyroid nodule assessment. Nodules with an indeterminate cytology (THY3a-f) require formal histological assessment to confirm benign or malignant pathology. This study aimed to provide data for an evidence-based approach for management of patients with THY3f nodules. Read More

Rev Assoc Med Bras (1992) 2022 Mar;68(3):400-404

Faculdade de Medicina da Escola Evangélica Mackenzie, Medical Research Institute - Curitiba (PR), Brazil.

Objective: Thyroid neoplasm incidence has increased worldwide, mostly due to the advancements in medical imaging and screening rates. The aberrant Wnt/β-catenin pathway has been identified as a key mechanism, and it has also been related to the metastatic activity of differentiated thyroid cancer. We aimed to verify the difference in the expression of Wnt3a, a canonical activator of the β-catenin signaling, and CDX-2, a transcription factor upregulated by Wnt/β-catenin pathway, in multinodular goiter and differentiated thyroid cancer and to determine their prognostic value. Read More

J Clin Pharm Ther 2022 Apr 18. Epub 2022 Apr 18.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.

What Is Known And Objective: Anti-CD19 CAR-T cell therapy is effective in B-cell lymphoma. However, it is rarely used in lymphoma combined with other malignant tumours.

Case Description: A relapsed/refractory follicular lymphoma (r/r FL) patient underwent anti-CD19 CAR-T cell therapy and achieved complete response to lymphoma. Read More

World J Gastroenterol 2022 Mar;28(11):1088-1101

Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

Pancreatic cancer is a disease with high unmet clinical need. Pancreatic cancer is also characterised by an intense fibrotic stroma, which harbours many immune cells. Studies in both human and animal models have demonstrated that the immune system plays a crucial role in modulating tumour onset and progression. Read More

World J Surg Oncol 2022 Apr 12;20(1):118. Epub 2022 Apr 12.

Department of Oncology, NHC Key Laboratory of Cancer Proteomics, XiangYa Hospital, Central South University, Changsha, 410008, China.

Background: Colon adenocarcinoma (COAD) is one of the most common malignant tumors and is diagnosed at an advanced stage with a poor prognosis worldwide. Pyroptosis is involved in the initiation and progression of tumors. This research focused on constructing a pyroptosis-related ceRNA network to generate a reliable risk model for risk prediction and immune infiltration analysis of COAD. Read More

Int J Surg Case Rep 2022 Mar 29;94:107001. Epub 2022 Mar 29.

ENT Head and Neck Surgery Department, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

Introduction: Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer subtype after papillary thyroid cancer (PTC), and it accounts for approximately 10% of all thyroid cancers, the incidence of distant metastasis in FTC has been reported to be 6-20%, bones and lungs are the most frequent sites of distant metastases. Most occult thyroid carcinomas are papillary carcinoma.

Case Presentation: We describe an extremely rare case of a 74-year-old woman who had a history of right thyroid lobectomy 20 years ago, was referred to our hospital for metastatic thyroid follicular carcinoma to the sacral region confirmed by the biopsy of the sacral mass. Read More

Cells 2022 Mar 31;11(7). Epub 2022 Mar 31.

Department of Glycoconjugate Biochemistry, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 30-387 Krakow, Poland.

Proteins carried by tumor-derived ectosomes play an important role in cancer progression, and are considered promising diagnostic markers. In the present study, a shotgun nanoLC-MS/MS proteomic approach was applied to profile and compare the protein content of ectosomes released in vitro by normal human thyroid follicular epithelial Nthy-ori 3-1 cells and human anaplastic thyroid carcinoma (TC) 8305C cells. Additionally, the pro-migratory and pro-proliferative effects of Nthy-ori 3-1- and 8305C-derived ectosomes exerted on the recipient cells were assessed in wound closure and Alamar Blue assays. Read More

Rep Pract Oncol Radiother 2022 22;27(1):121-124. Epub 2022 Mar 22.

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, United States.

Background: In patients with well-differentiated thyroid cancer, there is controversy about the prognostic importance of a large number of positive neck nodes and the potential value of radioiodine therapy. The purpose of this study was to evaluate this issue in the group of patients for whom it is most clinically important - those with classic histology and favorable T and M stage.

Materials And Methods: Twenty-five patients met the following inclusion criteria: classic histology of papillary or follicular thyroid carcinoma treated with total thyroidectomy and neck dissection followed by adjuvant I-131 treatment in our department between January 1, 2003, and December 31, 2013; adult age of > 21 years; and American Joint Committee on Cancer (AJCC ) stage (8 edition) of T0-3, N1b with ≥ 5 positive nodes, and M0. Read More

Surg Neurol Int 2022 25;13:109. Epub 2022 Mar 25.

King Abdullah International Medical Research Center.

Background: Metastatic brain lesions, of thyroid origin, are rare manifestations of differentiated thyroid cancer, with papillary thyroid carcinoma being the most common subtype. Considering the rarity of metastatic follicular thyroid carcinoma to the brain, the present article outlines its clinical presentation, neuroradiological findings, pathological features, and outcome.

Case Description: A 52-year-old female presented with a 6-month history of progressive and holocephalic headache. Read More

J Thorac Dis 2022 Mar;14(3):699-711

Department of Laboratory Medicine, Medical School of Chinese PLA, Beijing, China.

Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and has a dismal mortality rate of 80%, mainly due to diagnosis at an advanced stage. Biomarkers with high specificity and sensitivity for the early diagnosis of LUAD are sparse. This study aimed to identify markers for the early diagnosis of LUAD. Read More

Acta Med Indones 2022 Jan;54(1):138-141

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Even in immunocompromised patients, thyroid abscess is a rare occurrence. One factor that predisposes the thyroid gland to infection is pre-existing diseases such as thyroid nodule or thyroid cancer. A mass usually accompanies thyroid cancer. Read More