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    Value of cytokeratin-19, Hector Battifora mesothelial-1 and galectin-3 immunostaining in the diagnosis of thyroid neoplasms.
    J Lab Physicians 2018 Apr-Jun;10(2):200-207
    Department of Endocrinology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
    Background: Diagnosis of types and aggressiveness of thyroid cancers is difficult. The "gold standard" in diagnosis is using routine hematoxylin and eosin staining. Several markers have been investigated for differentiating them among which cytokeratin-19 (CK-19), Hector Battifora mesothelial cell (HBME-1), and galectin-3 are found to be most commonly used. Read More

    Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma.
    Clin Nucl Med 2018 Apr 23. Epub 2018 Apr 23.
    Background: Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. Read More

    Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer.
    J Bioenerg Biomembr 2018 Apr 23. Epub 2018 Apr 23.
    Department of Endocrinology, The Third People's Hospital of Guangxi Zhuang Autonomous Region, Riverside Hospital of Guangxi Zhuang Autonomous Region, Heti Road 85, Qingxiu District, Nanning, 530021, China.
    The clinical management of anaplastic thyroid carcinoma and follicular thyroid carcinoma is challenging and requires an alternative therapeutic strategy. Although atovaquone is an FDA-approved anti-malarial drug, studies has recently demonstrated its anti-cancer activities. In line with these efforts, our study shows that atovaquone is an attractive candidate for thyroid cancer treatment. Read More

    Follicular Thyroid Carcinoma in a Country of Endemic Iodine Deficiency (1994-2013).
    J Thyroid Res 2018 25;2018:6516035. Epub 2018 Feb 25.
    Department of Pathology, Korle-Bu Teaching Hospital, P.O. Box 77, Korle-Bu, Accra, Ghana.
    Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Read More

    Histopathological pattern of thyroid diseases in Zaria: A 10-year review.
    Niger Postgrad Med J 2018 Jan-Mar;25(1):37-42
    Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.
    Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens.

    Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Read More

    TERT, HRAS, and EIF1AX mutations in a patient with follicular adenoma.
    Thyroid 2018 Apr 19. Epub 2018 Apr 19.
    Thomas Jefferson University, Otolaryngology , 925 Chestnut Street , Philadelphia, Pennsylvania, United States , 19107 ;
    Background: Molecular markers are increasingly used as diagnostic tools in the management of thyroid nodules. There is a paucity of studies evaluating the prevalence of molecular markers in benign lesions.

    Patient Findings: A 68-year-old woman with hypothyroidism presented with a right thyroid nodule which was atypia of undetermined significance on cytology. Read More

    Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation.
    Surg Case Rep 2018 Apr 17;4(1):34. Epub 2018 Apr 17.
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, 89-1 Enya, Izumo, Shimane, 693-8501, Japan.
    Background: Carney complex (CNC) is a very rare disease. Although thyroid lesions are included in the diagnostic criteria for CNC, they are an infrequent occurrence.

    Case Presentation: The patient was a 69-year-old woman who had undergone the removal of a left atrial myxoma 10 years earlier, at the age of 59. Read More

    Thyroid-Like Intrahepatic Cholangiocarcinoma: Report of a Case and Review of the Literature.
    Int J Surg Pathol 2018 Apr 1:1066896918769381. Epub 2018 Apr 1.
    1 Department of Pathology, Fuzhou General Hospital of PLA, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou City, Fujian Province, China.
    Intrahepatic cholangiocarcinoma is a relatively uncommon malignant neoplasm. We recently encountered an unusual case of intrahepatic cholangiocarcinoma that histologically resembled a thyroid carcinoma. A thorough review of the English literature revealed only 2 similar cases that have been previously reported. Read More

    Positive Surgical Margins in Favorable-Stage Differentiated Thyroid Cancer.
    Am J Clin Oncol 2018 Apr 16. Epub 2018 Apr 16.
    Departments of Radiation Oncology.
    Objective: The significance of positive margin in favorable-stage well-differentiated thyroid cancer is controversial. We report outcomes of positive-margin patients with a matched-pair comparison to a negative-margin group.

    Materials And Methods: A total of 25 patients with classic-histology papillary or follicular carcinoma, total thyroidectomy +/- node dissection, stage T1-3N0-1bM0, positive surgical margin at primary site, adjuvant radioactive iodine (I-131), and age older than 18 years were treated between 2003 and 2013. Read More

    The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells.
    J Cell Biochem 2018 Apr 16. Epub 2018 Apr 16.
    Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.
    Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins. Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC-133, and papillary K1 thyroid carcinoma cells were rich in α-2,6, α-2,3, sialic acid, and α-1,6 fucose residues. Read More

    Role of Preablative Stimulated Thyroglobulin in Prediction of Nodal and Distant Metastasis on Iodine Whole-Body Scan.
    Indian J Nucl Med 2018 Apr-Jun;33(2):93-98
    Department of Endocrinology, Diabetes and Metabolism, Narayana Health City, Bengaluru, Karnataka, India.
    Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (I WBS) in the management of low-to-intermediate-risk DTC patients. Read More

    Cytopathology of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: A comparative study with similar patterned papillary thyroid carcinoma variants.
    Cytopathology 2018 Apr 11. Epub 2018 Apr 11.
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
    Objective: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently described, indolent thyroid tumor, with well-defined histopathological diagnostic criteria. Cytology features are not well documented. We reviewed cytology of histologically proven cases of NIFTP and some of its common differentials to look for salient diagnostic features. Read More

    The Spectrum of Thyroid Gland Pathology in Carney Complex: The Importance of Follicular Carcinoma.
    Am J Surg Pathol 2018 May;42(5):587-594
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
    The initial description of Carney complex (CNC) in 1985 included myxomas, spotty skin pigmentation, and endocrine overactivity (of the adrenal, the pituitary, and the testis). In 1997, thyroid neoplasms were found in 3 patients with CNC and involvement of the gland in the syndrome was apparent. Herein, we describe the clinical, pathologic, and follow-up findings in 26 patients with CNC and a disorder of the thyroid gland. Read More

    Impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features on the Bethesda system for reporting thyroid cytopathology: a multi-institutional study in five Asian countries.
    Pathology 2018 Apr 6. Epub 2018 Apr 6.
    Department of Pathology, Nara Hospital, Kindai University Faculty of Medicine, Nara, Japan.
    Several Western studies showed that the recent introduction of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) significantly decreased risk of malignancy for cytological diagnostic categories. We aimed to determine the impact of NIFTP on risk of malignancy within a cohort of thyroid nodules from Asian countries, and to compare distribution of diagnostic categories between NIFTP and invasive encapsulated follicular variant of papillary thyroid carcinoma (eFV-PTC). Consecutive thyroid fine-needle aspirates from six institutions were retrospectively analysed. Read More

    Molecular markers in well-differentiated thyroid cancer.
    Eur Arch Otorhinolaryngol 2018 Apr 6. Epub 2018 Apr 6.
    International Head and Neck Scientific Group, Padua, Italy.
    Purpose: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. Read More

    Case report: Whole exome sequencing of circulating cell-free tumor DNA in a follicular thyroid carcinoma patient with lung and bone metastases.
    J Circ Biomark 2018 Jan-Dec;7:1849454418763725. Epub 2018 Mar 25.
    Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
    Metastatic follicular thyroid carcinoma (FTC), unresectable or resistance to radioactive iodine, is associated with poor survival. It is believed that this kind of FTC is driven by mutated genes. However, what kind of changes of genome and underlying mechanisms are elusive. Read More

    Unusual Presentation of Differentiated Thyroid Cancer Metastasis.
    Int Arch Otorhinolaryngol 2018 Apr 14;22(2):167-170. Epub 2017 Jul 14.
    Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
     The rates of thyroid cancers are on a rise, especially well-differentiated thyroid cancers. This could be partly due to newer diagnostic modalities, like high-resolution ultrasound, that can pick up smaller lesions. Differentiated thyroid cancers with distant metastases are not common, and even rarer is the initial presentation with complaints not related to the neck. Read More

    Prognostic value of the 8 tumor-node-metastasis classification for follicular carcinoma and poorly differentiated carcinoma of the thyroid in Japan.
    Endocr J 2018 Apr 4. Epub 2018 Apr 4.
    Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan.
    Follicular thyroid carcinoma (FTC), a form of differentiated thyroid carcinoma, is the second most common malignancy arising from thyroid follicular cells. Recently, the tumor-node-metastasis (TNM) classification for differentiated thyroid carcinoma was revised from the 7 to the 8 edition. The diagnostic criteria for poorly differentiated carcinoma (PDC) were also updated in the latest World Health Organization (WHO) classification. Read More

    Malignant Solitary Fibrous Tumor Metastatic to Widely Invasive Hurthle Cell Thyroid Carcinoma: A Distinct Tumor-to-Tumor Metastasis.
    Int J Surg Pathol 2018 Apr 1:1066896918767321. Epub 2018 Apr 1.
    1 The Royal Marsden NHS Foundation Trust, London, UK.
    We illustrate a case of synchronous malignant solitary fibrous tumor of the thoracic cavity, and widely invasive thyroid Hurthle cell carcinoma. The Hurthle cell carcinoma was found to harbor distinct areas of malignant solitary fibrous tumor. This is a unique case of tumor-to-tumor metastasis that, to the best of our knowledge, has not been previously reported. Read More

    Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features and Its Impact on the Risk of Malignancy in the Bethesda System for Reporting Thyroid Cytopathology: An Institutional Experience.
    J Pathol Transl Med 2018 Apr 3. Epub 2018 Apr 3.
    Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
    Background: This study was performed to analyze cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and its impact on the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).

    Materials And Methods: 5549 cases of thyroid fine-needle aspiration cytology (FNAC) diagnosed between 2012 and 2014 were included in this study. Diagnostic categories based on TBSRTC were compared with final surgical diagnoses, and the ROM in each category was calculated both including and excluding NIFTP from the malignant lesions. Read More

    Diagnosing between papillary carcinoma and reactive papillary changes in an infarcted thyroid nodule after fine needle aspiration and accompanied by a synchronous brain stem astrocytoma.
    North Clin Istanb 2018 10;5(1):67-71. Epub 2018 Jan 10.
    Department of General Surgery, Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
    A 22-year-old patient underwent fine needle aspiration of a nodule at the outer center of the right lobe of the thyroid, and it was reported to be Bethesda system category IV, Hurthle cell follicular neoplasia. The patient, who persented to Onsekiz Mart University Research and Application Hospital, underwent surgery. During right total thyroidectomy, an almost totally infarcted nodule and papillary structures around these infarcted areas were detected. Read More

    Solid Papillary Breast Carcinomas Resembling the Tall Cell Variant of Papillary Thyroid Neoplasms (Solid Papillary Carcinomas with Reverse Polarity) Harbor Recurrent Mutations Affecting IDH2 and PIK3CA: A Validation Cohort.
    Histopathology 2018 Mar 30. Epub 2018 Mar 30.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Aims: Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histologic type of breast cancer that morphologically resembles the tall cell variant of papillary thyroid carcinoma. BPTCs are characterized by IDH2 R172 hotspot somatic mutations or mutually exclusive TET2 somatic mutations, concurrently with mutations affecting PI3K pathway-related genes. We sought to characterize their histology, and investigate the frequency of IDH2 and PIK3CA mutations in an independent cohort of BPTCs, as well as in conventional solid papillary carcinomas (SPCs). Read More

    Thyroid nodules and cancer in children and adolescents affected by hashimoto's thyroiditis.
    Br J Radiol 2018 Apr 9:20180014. Epub 2018 Apr 9.
    Department of Radiology, Soonchunhyang University Bucheon Hospital , Bucheon , Korea.
    Objective: To investigate the rates of thyroid nodules and cancer in pediatric cases of Hashimoto's thyroiditis (HT) in Korea.

    Methods: We retrospectively reviewed 89 pediatric and adolescent patients (age, 3-18.0 years) with HT who underwent thyroid ultrasonography (US) at our institution from February 2006 to July 2016. Read More

    A Case Report of Syndromic Multinodular Goitre in Adolescence: Exploring the Phenotype Overlap between Cowden and DICER1 Syndromes.
    Eur Thyroid J 2018 Jan 21;7(1):44-50. Epub 2017 Nov 21.
    Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia.
    Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome.

    Material And Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Read More

    Noninvasive Follicular Thyroid Neoplasms With Papillary-Like Nuclear Features (NIFTPs) Are Genetically and Biologically Similar to Adenomatous Nodules and Distinct From Papillary Thyroid Carcinomas With Extensive Follicular Growth.
    Arch Pathol Lab Med 2018 Mar 27. Epub 2018 Mar 27.
    From the Divisions of Anatomic Pathology (Drs Johnson, Antic, and Cipriani) and Molecular Pathology (Messrs Long, Zhen, and Mujacic; Ms Wurst; and Drs Kadri and Segal), Department of Pathology, University of Chicago, Chicago, Illinois; and the ARUP Laboratories, University of Utah, Salt Lake City (Dr Furtado).
    Context: - Proposed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTPs), formerly noninvasive encapsulated papillary carcinoma, follicular variant (PTC-FV), is an indolent tumor with follicular growth and frequent RAS mutations.

    Objective: - To detect histologic and molecular differences separating NIFTP from follicular adenomas (FAs) and invasive carcinomas, particularly papillary carcinomas with extensive follicular growth (PTC-EFGs) and invasive encapsulated PTC-FV (IE-PTC-FV).

    Design: - Sixty-one tumors were reviewed histologically and reclassified into 32 NIFTPs (52%), 4 IE-PTC-FVs (7%), 14 PTC-EFGs (23%), and 11 FAs (18%). Read More

    CXCR4/CXCR7/CXCL12-Axis in Follicular Thyroid Carcinoma.
    J Cancer 2018 27;9(6):929-940. Epub 2018 Feb 27.
    Department of Surgery (A), Heinrich-Heine-University and University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
    Follicular thyroid carcinoma's (FTC) often benign course is partially due to adjuvant radioactive iodine (RAI) treatment. However, once the tumour has spread and fails to retain RAI, the therapeutic options are limited and the outcome is poor. In this subset of patients, the identification of novel druggable biomarkers appears invaluable. Read More

    Thyroid Nodule Management: Thyroid-Stimulating Hormone, Ultrasound, and Cytological Classification System for Predicting Malignancy.
    Cancer Inform 2018 19;17:1176935118765132. Epub 2018 Mar 19.
    Department of Endocrinology, Henri Mondor Hospital, Paris, France.
    Background/objectives: Thyroid nodule (TN) is a common thyroid disorder globally, and the incidence has been increasing in recent decades. The objective of this study was to determine the contribution of thyroid-stimulating hormone (TSH), ultrasound (US), and cytological classification system for predicting malignancy among the surgically excised nodules.

    Design And Methods: A retrospective analysis was performed between January 2012 and December 2014, using data drawn from 1188 patients (15-90 years), who had 1433 TN and fine-needle aspiration in Prince Sultan Military Medical City, Saudi Arabia. Read More

    Overt Skeletal Metastases in a Patient of Occult (Microscopic) Follicular Thyroid Carcinoma: a Rare Case.
    Indian J Surg Oncol 2018 Mar 30;9(1):68-70. Epub 2017 Sep 30.
    3Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014 India.
    Occult follicular thyroid carcinoma (FTC) presenting as distant metastases is a rare occurrence. However, despite being occult in majority of these cases, primary tumor can be detected on thyroid imaging or during surgery. Here, we present an extremely rare case of an occult FTC with overt skeletal metastases in which primary tumor was discernible only on microscopic examination. Read More

    Importance of Number of Foci of Capsular Invasion in Follicular Thyroid Carcinoma.
    Indian J Surg Oncol 2018 Mar 24;9(1):6-10. Epub 2016 Dec 24.
    1Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014 India.
    The importance of capsular invasion in follicular thyroid carcinoma (FTC) has not been extensively studied. The aim of the present study was to correlate the clinical features and outcome of FTC with histology features particularly emphasizing on the importance of the number of foci of capsular invasion. This was a retrospective study. Read More

    Routine histopathological study of cholecystectomy specimens. Useful? A retrospective study of 1960 cases.
    Acta Gastroenterol Belg 2017 Jul-Sep;80(3):365-370
    University of Tunis El Manar, Tunis Faculty of Medicine, Tunisia.
    Background And Aims: Traditionally, a gallbladder removed for presumed benign disease is sent for histopathological examination, but this practice has been the subject of controversy.

    Aim: The aim of this study was to assess the usefulness of routine histopathological examination of cholecystectomy specimens and its impact on the management of patients.

    Patients And Methods: The histopathological reports of 1960 patients who underwent cholecystectomy from January 2011 to November 2016 were retrospectively reviewed. Read More

    LIMD2 Is Overexpressed in BRAF V600E-Positive Papillary Thyroid Carcinomas and Matched Lymph Node Metastases.
    Endocr Pathol 2018 Mar 20. Epub 2018 Mar 20.
    Genetic Bases of Thyroid Tumors Laboratory, Department of Morphology and Genetics, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669-11 andar, São Paulo, SP, Brazil.
    We previously described that LIM domain containing 2 (LIMD2) overexpression was closely correlated with metastatic process in papillary thyroid carcinoma (PTC). We here evaluated the expression of LIMD2 in a series of non-metastatic and metastatic PTC and their matched lymph node metastases via immunohistochemistry. LIMD2 was expressed in 74 (81%) of primary PTC and 35 (95%) of lymph node metastases. Read More

    Identification of a novel variant and its association with papillary thyroid carcinoma.
    Oncol Lett 2018 Apr 17;15(4):4511-4516. Epub 2018 Jan 17.
    Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
    HRas proto-oncogene () is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. The aim of the present study was to investigate the somatic genetic variants present in in patients with PTC, and to investigate the association of these mutations with PTC. Read More

    Expression of human telomerase reverse transcriptase (hTERT) in thyroid neoplasms.
    J BUON 2018 Jan-Feb;23(1):229-233
    Health Sciences University, Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey.
    Purpose: Distinction of thyroid neoplasms that include papillary carcinoma (PC) and follicular carcinoma (FC) from benign thyroid neoplasms can be performed successfully by histopathologic examination in most of the cases. However, in some cases it may be difficult to distinct PC and FC as well as FC and follicular adenoma (FA) and also FA and the dominant nodule of multinodular goiter (MNG) histopathologically. In this study, we aimed to determine the role of expression of the human telomerase reverse transcriptase (hTERT) in the distinction of thyroid neoplasms and its relation with prognostic factors by immunohistochemical methods. Read More

    Acute paraparesis as presentation of an occult follicular thyroid carcinoma: A case report.
    Int J Surg Case Rep 2017 28;41:498-501. Epub 2017 Nov 28.
    Internal Medicine Department (BB), Centro Hospitalar e Universitário de Coimbra (Hospital Geral-Covões), S. Martinho de Bispo, 3041-853 Coimbra, Portugal. Electronic address:
    Introduction: Follicular thyroid carcinoma is the second most frequent type of well differentiated thyroid tumours. It is usually confined to the thyroid gland, however it can metastasize in a later stage of the disease. Signs and symptoms associated with bone metastasis are rare as first clinical manifestations. Read More

    Thyroid cancer: trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China.
    BMC Cancer 2018 03 15;18(1):291. Epub 2018 Mar 15.
    Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, 388 Yu-Hang-Tang Road, Zhejiang, Hangzhou, 310058, China.
    Background: Thyroid cancer is the most common malignant disease of the endocrine system. Previous studies indicate a rapid increase in the incidence of thyroid cancer in recent decades, and this increase has aroused the great public concern. The aim of this study was to analyze the trends in incidence, mortality and clinical-pathological patterns of thyroid cancer in Zhejiang province. Read More

    Derivation of thyroid lymphoepithelial cysts from follicular cells.
    Endocr J 2018 Mar 14. Epub 2018 Mar 14.
    Department of Surgery, Kuma Hospital, Kobe, Hyogo, Japan.
    The pathogenesis of thyroid lymphoepithelial cysts is controversial, and two hypotheses have been proposed, namely derivation from branchial-derived remnants or from squamous metaplasia of the follicular cells. The aim of this study was to clarify the pathogenesis of thyroid lymphoepithelial cysts. We performed pathological and immunohistochemical examination of 21 thyroid lymphoepithelial cysts, 13 non-neoplastic squamous metaplasia samples without thyroid carcinoma, 13 solid cell nests, and 14 lateral cervical cysts. Read More

    Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
    Am J Clin Pathol 2018 Mar;149(5):379-386
    Department of Pathology Pediatric Department, Centro Hospitalar São João, Porto, Portugal.
    Objectives: Multinodular goiter (MNG) and well-differentiated thyroid carcinoma (WDTC) are emerging phenotypes of DICER1 syndrome.

    Methods: Histologic and molecular findings of botryoid-type embryonal rhabdomyosarcoma (bERMS) and thyroid nodules from a 12-year-old DICER1 mutation carrier (p.Arg1060Ilefs*7) were investigated, providing interesting clues for understanding thyroid carcinogenesis. Read More

    [Hormone-producing thyroid carcinoma in a female 10-year-old Australian Cattle Dog].
    Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Feb 21;46(1):35-40. Epub 2018 Feb 21.
    A 10-year-old female Australian Cattle Dog was referred for investigation of a mediastinal mass. During clinical examination, a mandarin- sized mass was detected ventrally of the trachea. According to computed tomographic (CT) findings and cytology of a fine-needle aspirate, thyroid neoplasia was suspected. Read More

    Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution.
    Oncotarget 2018 Feb 8;9(12):10343-10359. Epub 2017 Dec 8.
    Institute of Interdisciplinary Research (IRIBHM), Université libre de Bruxelles (ULB), Brussels, Belgium.
    Non-autonomous thyroid nodules are common in the general population with a proportion found to be cancerous. A current challenge in the field is to be able to distinguish benign adenoma (FA) from preoperatively malignant thyroid follicular carcinoma (FTC), which are very similar both histologically and genetically. One controversial issue, which is currently not understood, is whether both tumor types represent different molecular entities or rather a biological continuum. Read More

    Risk factors associated with malignancy and with triage to surgery in thyroid nodules classified as Bethesda category IV (FN/SFN).
    Diagn Cytopathol 2018 Mar 10. Epub 2018 Mar 10.
    Department of Pathology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
    Background: Thyroid nodules diagnosed as Bethesda category IV [follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)] are recommended for surgery. However, only 10%-40% of these nodules turn out to be malignant on histopathological examination. Therefore, selection for surgery of nodules diagnosed as Bethesda category IV is important. Read More

    Serum calcitonin negative mixed medullary-follicular carcinoma initially diagnosed as medullary thyroid carcinoma by fine-needle aspiration cytology: A case report and review of the literatures.
    Diagn Cytopathol 2018 Mar 10. Epub 2018 Mar 10.
    Department of Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Medullary thyroid carcinoma (MTC) is potentially lethal. A prompt and accurate diagnosis is the prerequisite for the treatment of MTC. Fine-needle aspiration (FNA) is a reliable diagnostic tool in the assessment of thyroid nodules. Read More

    Bone metastases without primary tumor: A well-differentiated follicular thyroid carcinoma case.
    J Cancer Res Ther 2018 Jan-Mar;14(2):447-450
    Department of Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
    Metastases to the bone are the most common malignant bone tumors. Prostate, breast, and lung carcinomas are the most common primaries of bone metastases. Bone metastases show poor prognosis in means of median survival; however, some patients with highly curable tumors such as thyroid carcinoma may benefit from treatment. Read More

    A study of clinicopathological characteristics of thyroid carcinoma at a Tertiary Care Center.
    J Cancer Res Ther 2018 Jan-Mar;14(2):357-360
    Department of Pathology, Mahavir Cancer Sansthan, Patna, Bihar, India.
    Context: To share clinicopathological data of thyroid carcinoma from a high volume Tertiary Care Centre in East India.

    Aim: To share the epidemiology and clinicopathological presentation of thyroid cancer at a high volume Tertiary Care Center in East India.

    Settings And Design: Retrospective observational study. Read More

    LncRNA HCP5 promotes follicular thyroid carcinoma progression via miRNAs sponge.
    Cell Death Dis 2018 Mar 7;9(3):372. Epub 2018 Mar 7.
    Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
    Long non-coding RNAs (lncRNAs), which are important functional regulators in cancer, have received increased attention in recent years. In this study, next-generation sequencing technology was used to identify aberrantly expressed lncRNAs in follicular thyroid carcinoma (FTC). The long non-coding RNA-HLA complex P5 (HCP5) was found to be overexpressed in FTC. Read More

    Ubiquitin Immunostaining in Thyroid Neoplasms Marks True Intranuclear Cytoplasmic Pseudoinclusions and May Help Differentiate Papillary Carcinoma from NIFTP.
    Head Neck Pathol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Pathology, The University of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.
    Papillary thyroid carcinoma (PTC) is defined by an invasive growth pattern and classic nuclear features: enlarged, grooved, overlapping nuclei with chromatin clearing and intranuclear cytoplasmic pseudoinclusions (INCP). True INCPs are characteristic of PTC, but may infrequently be seen in noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). Nuclear abnormalities that mimic INCP ("pseudo-pseudoinclusions") are common in a variety of thyroid lesions. Read More

    Tumour growth rate of follicular thyroid carcinoma is not different from that of follicular adenoma.
    Clin Endocrinol (Oxf) 2018 Mar 6. Epub 2018 Mar 6.
    Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Objective: Distinguishing malignancy from benign thyroid nodule has always been challenging, especially in follicular lesions. Thyroid nodules with small size and indeterminate cytology do not lead to immediate surgery. We tried to evaluate whether tumour size and tumour growth rate can distinguish follicular thyroid carcinoma (FTC) from follicular adenoma (FA). Read More

    Identification of metastatic papillary thyroid carcinoma in FNA specimens using thyroid peroxidase immunohistochemistry.
    Cytopathology 2018 Mar 6. Epub 2018 Mar 6.
    Histopathology Department, Sullivan Nicolaides Pathology, Brisbane, Qld, Australia.
    Introduction: We evaluated immunohistochemical staining for thyroid peroxidase (TPO), a glycoprotein found in the apical plasma membrane of thyroid follicular cells, as a marker for metastatic PTC in FNA samples and compared results with thyroglobulin (Tg) and thyroid transcription factor 1 (TTF1) staining.

    Methods: Cell block sections prepared from 100 FNA specimens were stained with a rabbit monoclonal antibody to TPO (EP159). The FNAs included 64 metastatic malignancies from non-thyroid primary sites, including 18 lung, and 36 cases of thyroid tumours (29 PTC, six cases of medullary thyroid carcinoma and one thyroid anaplastic carcinoma). Read More

    An International Interobserver Variability Reporting of the Nuclear Scoring Criteria to Diagnose Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: a Validation Study.
    Endocr Pathol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
    The aim of the study was to assess interobserver variation in reporting nuclear features of encapsulated follicular variant of papillary thyroid carcinoma, newly reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), based on a proposed standardized scoring system. An education module was individually reviewed as a pre-evaluation teaching guide of the specific features of classical papillary carcinoma, the specific inclusion and exclusion features for the diagnosis of NIFTP, and a catalog of the standardized scoring system of the nuclear features of papillary carcinoma used to reach this diagnosis. Participants subsequently reviewed 30 cases of thyroid lesions previously scored by members of the Endocrine Pathology Society Working Group for the Re-evaluation of the Encapsulated Follicular Variant of Papillary Thyroid Carcinoma. Read More

    Racial disparities of differentiated thyroid carcinoma: clinical behavior, treatments, and long-term outcomes.
    World J Surg Oncol 2018 Mar 5;16(1):45. Epub 2018 Mar 5.
    Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, 430071, China.
    Background: The incidence of thyroid cancer in black Americans is significantly lower than that in white Americans, and the impact of race on the prognosis of thyroid cancer remains controversial. The purpose of this study was to determine the risk factors for survival in black and white patients and to compare the survival of differentiated thyroid carcinoma subtypes between these two races. We further investigated the association of lymph node and distant metastases with races. Read More

    ENHANCED BETA-CATENIN EXPRESSION IS ASSOCIATED WITH THE RECURRENCE OF PAPILLARY THYROID CARCINOMA.
    Endocr Pract 2018 Mar 2. Epub 2018 Mar 2.
    Global Health Science University of California San Francisco USA.
    Objective: A direct role of Catenin beta-1(βcat) in the proliferation of human thyroid tumor cells has been identified. This study aimed to determine if there is an association between βcat gene expression and the staging, recurrence, metastasis, and disease free survival of papillary thyroid cancer.

    Methods: A retrospective cohort study was conducted using data from available information in the medical records and paraffin blocks of 81 of 400 patients referred to the endocrine clinic over a 10-year period. Read More

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