Search our Database of Scientific Publications and Authors

I’m looking for a

    8505 results match your criteria Thyroid Follicular Carcinoma

    1 OF 171

    Molecular Markers Involved in Tumorigenesis of Thyroid Carcinoma: Focus on Aggressive Histotypes.
    Cytogenet Genome Res 2017 Feb 24. Epub 2017 Feb 24.
    Programa de Pós Graduação em Endocrinologia da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma. Papillary thyroid carcinoma is the most common endocrine cancer, and its incidence is steadily increasing. Lethality and aggressiveness of TCDFC is inversely correlated with differentiation degree. Read More

    Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir.
    Toxicol In Vitro 2017 Feb 18. Epub 2017 Feb 18.
    Section of Clinical Biochemistry and Molecular Genetics, Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Italy. Electronic address:
    Besides its well-recognized antiviral activity, Cidofovir (CDV) has been shown to exert anticancer properties both within in vitro and in vivo models. The aim of this study was to evaluate the effects of CDV on still unexplored cultured cancer cells from human mesothelioma as well as breast, colon, liver, lung, prostate, and thyroid carcinomas. Overall, a dose- and time-dependent inhibition of cell viability was observed after CDV exposure. Read More

    Encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with Spindle Cell Metaplasia: Case report and review of literature.
    Pathol Res Pract 2017 Jan 5. Epub 2017 Jan 5.
    Department of Pathology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, USA. Electronic address:
    Spindle cell lesions of the thyroid are rare overall, and span a wide clinical spectrum that ranges from spindle cell metaplasia (SCM(1)) to anaplastic carcinoma. Their differentiation is only seldom straightforward, and usually requires the integration of the clinical, histological and immunohistochemical data. Only a handful of publications have described cases of SCM in the thyroid and we add to that literature by reporting a unique case of encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with SCM. Read More

    Diagnostic utility of CK19 and CD56 in the differentiation of thyroid papillary carcinoma from its mimics.
    Pathol Res Pract 2017 Jan 22. Epub 2017 Jan 22.
    Department of Pathology,Ahmed Maher Teaching Hospital, Cairo, Egypt.
    Background: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. Read More

    Study of Immunohistochemical Markers (CK-19, CD-56, Ki-67, p53) in Differentiating Benign and Malignant Solitary Thyroid Nodules with special Reference to Papillary Thyroid Carcinomas.
    J Clin Diagn Res 2016 Dec 1;10(12):EC14-EC19. Epub 2016 Dec 1.
    Post Graduate Student, Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital , Pune, Maharashtra, India .
    Introduction: Solitary Thyroid Nodule (STN) has provoked increased concern owing to higher incidence of malignancy. The inter and intra observer variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas (PTC) may sometimes pose a diagnostic difficulty.

    Aim: This study was undertaken to analyse immunohistochemical (IHC) markers (CK-19, CD-56, p53, Ki-67) to differentiate between benign and malignant surgically resected STN along with their utility in the identification of PTC. Read More

    A 'silent' skull metastatic follicular thyroid carcinoma mimicking as a benign scalp tumor in a pregnant woman.
    Endocrinol Diabetes Metab Case Rep 2017 12;2017. Epub 2017 Jan 12.
    Departments of Plastic and Reconstructive Surgery.
    : Thyroid cancer with cranial metastasis in a pregnant woman is very rare. In the literature, most cases are diagnosed early from neurogenic signs or symptomatic thyroid gland. Pregnancy also contributes to a hesitation toward early surgical and medical treatments. Read More

    Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma.
    Cancer 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
    Background: The noninvasive follicular variant of papillary thyroid carcinoma (PTC) has an indolent clinical behavior in comparison with other PTCs, including the invasive follicular variant of papillary thyroid carcinoma (IFVPTC). Recently, the term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced to emphasize the low biological potential of these tumors. This study compares clinical, cytological, and molecular features of NIFTP and IFVPTC. Read More

    Oncocytic Variant of Medullary Thyroid Carcinoma: A Rare Case of Sporadic Multifocal and Bilateral RET Wild-Type Neoplasm with Revision of the Literature.
    Rare Tumors 2016 Nov 20;8(4):6537. Epub 2016 Dec 20.
    Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Gemelli Hospital, Rome Italy.
    Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland. It generally has a slight female predominance and appears as a single lesion. Read More

    Diffuse Follicular Variant of Papillary Thyroid Carcinoma: A Case Report with a Revision of Literature.
    Rare Tumors 2016 Nov 20;8(4):6536. Epub 2016 Dec 20.
    Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Italy.
    The diffuse follicular variant of papillary thyroid carcinoma (DFV-PTC) is a rare malignant thyroid condition. It represents an uncommon variant of papillary carcinoma characterized by a diffuse involvement of thyroid parenchyma, follicular architecture and nuclear features of PTC in absence of a surrounding capsule. Up to date few data have been collected about this entity and, at the best of our knowledge, only 24 cases have been reported in the literature. Read More

    Evaluation of thyroid nodules classified as Bethesda category III on FNAC.
    J Cytol 2017 Jan-Mar;34(1):5-9
    Department of Pathology, Seth G.S.M.C. and KEM Hospital, Mumbai, Maharashtra, India.
    Background: The Bethesda (BSRTC) category III has been ascribed a malignancy rate of 5-15%, however, the probability of malignancy remains variable.

    Aim: To evaluate category III with respect to its rate and risk of malignancy and substratify it.

    Settings And Design: Atypia of undetermined significance/Follicular lesion of undetermined significance (AUS/FLUS) percentage, cytohistological correlation, and risk of malignancy were analyzed and substratification was done. Read More

    Frontal bone metastasis from an occult follicular thyroid carcinoma: Diagnosed by FNAC.
    J Cytol 2017 Jan-Mar;34(1):59-61
    Department of Pathology, PGIMS, Rohtak, India.
    Metastatic deposits in skull bones from follicular thyroid carcinoma is rare, and metastatic disease in skull being the presenting symptom without obvious thyroid lesion (occult primary) is even rarer. A 60-year-old female patient presented with a mass in the frontal region of the skull. Fine needle aspiration cytology was done which revealed an adenocarcinoma with repeated follicular pattern, reminiscent of follicular neoplasm of thyroid, which on immunocytochemistry revealed positivity for thyroglobulin. Read More

    Dysadherin specific drug conjugates for the treatment of thyroid cancers with aggressive phenotypes.
    Oncotarget 2017 Jan 30. Epub 2017 Jan 30.
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
    Background: EDC1 is a novel type of antibody-drug conjugate which binds and inhibits the Na,K-ATPase on the surface of cancer cells expressing dysadherin. The purpose of this study was to determine the expression of dysadherin in different types of thyroid carcinoma, and evaluate the therapeutic potential of EDC1 for thyroid carcinomas.

    Methods: Thyroid tissues from 158 patients were examined for dysadherin expression and correlation with clinicopathological features. Read More

    Evaluation of thyroid lesions by fine-needle aspiration cytology based on Bethesda system for reporting thyroid cytopathology classification among the population of South Bihar.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):265-270
    Department of Pathology, Patna Medical College and Hospital, Patna, Bihar, India.
    Background: Fine-needle aspiration (FNA) of the thyroid gland has proven to be an important and widely accepted, cost-effective, simple, safe, and accurate method triaging patients with thyroid nodules. Awareness and understanding of wide spectrum thyroid disorders are of great value because most lesions are treatable by medical or surgical management.

    Aim: The aim of this study is to determine the accuracy of FNA cytology (FNAC) in the diagnosis of thyroid lesion using the Bethesda system for reporting thyroid cytopathology nomenclature (BSRTC) and to correlate these with histopathological findings. Read More

    Outcome of large noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
    Thyroid 2017 Jan 30. Epub 2017 Jan 30.
    Memorial Sloan-Kettering Cancer Center, Pathology , 1275 York Avenue , New York, New York, United States , 10021 ;
    Background: In 2016, encapsulated papillary thyroid carcinoma, follicular variant without invasion was renamed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, many endocrinologists remain uneasy about managing large (≥ 4 cm) NIFTP conservatively without radioactive iodine (RAI) therapy. The objectives of this study are to characterize the clinicopathologic characteristics and outcome of large NIFTP in order to assist therapeutic decision making. Read More

    False-positive cytopathology results for papillary thyroid carcinoma: A trap for thyroid surgeons.
    Clin Otolaryngol 2017 Jan 28. Epub 2017 Jan 28.
    Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
    Objectives: Current preoperative diagnosis of thyroid nodules remains imperfect despite recent advances in cytopathology and molecular diagnostics. False-positivity in preoperative fine needle aspiration cytology (FNAC) may lead to overtreatment of patients, including total thyroidectomy, and sometimes to lawsuits for misdiagnosis and malpractice. In this study, we analyzed clinical characteristics and pathologic findings in patients with false-positivity for papillary thyroid carcinoma (PTC) in FNAC. Read More

    Clinical and Morphologic Features of ETV6-NTRK3 Translocated Papillary Thyroid Carcinoma in an Adult Population Without Radiation Exposure.
    Am J Surg Pathol 2017 Jan 25. Epub 2017 Jan 25.
    *Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA †Department of Pathology and Laboratory Medicine, New York University Langone Medical Center, New York, NY.
    The ETV6-NTRK3 translocation characterizes a subset of radiation associated and pediatric papillary thyroid carcinomas (PTCs). We now describe the clinicopathologic features of ETV6-NTRK3 translocated PTC in an adult population without radiation exposure. Twelve cases were identified by next-generation sequencing (ThyroSeq version 2). Read More

    RASSF1A promoter methylation is associated with increased risk of thyroid cancer: a meta-analysis.
    Onco Targets Ther 2017 9;10:247-257. Epub 2017 Jan 9.
    Department of Cardiovascular Diseases.
    Objective: Previous studies have reported that Ras-associated domain family 1A (RASSF1A), the most commonly silenced tumor suppressor via promoter methylation, played vital roles in the development of carcinogenesis. The purpose of this meta-analysis was to determine whether RASSF1A promoter methylation increased the risk of thyroid cancer.

    Methods: PubMed, Embase, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure databases were searched to obtain eligible studies. Read More

    Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs.
    Open Vet J 2016 19;6(3):247-254. Epub 2016 Dec 19.
    Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, Montevideo, Uruguay.
    Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Read More

    The ATA Guidelines on Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of eFVPTC without Invasion to NIFTP.
    Thyroid 2017 Jan 23. Epub 2017 Jan 23.
    The University of Texas M. D. Anderson Cancer Center, Pathology , 1515 Holcombe Blvd, Unit 085 , Houston, Texas, United States , 77030 ;
    American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on and make recommendations related to the suggested new classification of Encapsulated Follicular Variant Papillary Thyroid Carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with the recusal of three members who were authors on the paper under review. Four pathologists and one endocrinologist were added for this specific review. Read More

    NIFTP Accounts for Over Half of "Carcinomas" Harboring RAS Mutations.
    Thyroid 2017 Jan 23. Epub 2017 Jan 23.
    Brigham and Women's Hospital, Pathology , 75 Francis Street , Boston, Massachusetts, United States , 02115 ;
    Background: Molecular testing of thyroid nodules is increasingly being utilized to guide clinical management decisions. RAS mutations are the most frequent mutations detected in the context of an indeterminate fine needle aspiration (FNA) diagnosis. The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently introduced to promote conservative management of tumors previously classified as noninvasive follicular variant of papillary thyroid carcinoma (FVPTC). Read More

    Frequency of Thyroid Carcinoma in Brazilian TP53 p.R337H Carriers With Li Fraumeni Syndrome.
    JAMA Oncol 2017 Jan 19. Epub 2017 Jan 19.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute/National Institutes of Health, Bethesda, Maryland.
    Importance: Li Fraumeni syndrome (LFS) is associated with a wide variety of tumors; nevertheless, thyroid carcinoma has not been evaluated in this syndrome. Due to the Brazilian founder mutation p.R337H, some tumors that have not been described in the classic LFS have been observed in a higher-than-expected prevalence in Brazil. Read More

    BRAF(K601E) Mutation in a Follicular Thyroid Adenoma.
    Int J Surg Pathol 2017 Jan 1:1066896916688083. Epub 2017 Jan 1.
    1 University of Pisa, Pisa, Italy.
    BRAF mutations represent the most common genetic alteration in papillary thyroid carcinoma (PTC). The p.V600E mutation is specific for the classic and tall-cell variants of PTC and has been associated with a more aggressive biologic behavior. Read More

    Follicular thyroid carcinoma presenting with pathological fracture of the humerus at initial diagnosis.
    J Surg Case Rep 2017 Jan 19;2017(1). Epub 2017 Jan 19.
    Department of Otorhinolaryngology, Head and Neck Surgery, Leicester Royal Infirmary, Infirmary Square, LE1 5WW, UK.
    Differentiated carcinomas of the thyroid gland usually have a good prognosis with prognosis often discussed in terms of 20 year survival. Nevertheless its 10-year-survival rate decreases when accompanied by distant metastasis. Follicular thyroid cancer (FTC) is the second most common thyroid cancer and usually presents with a solitary thyroid nodule with or without cervical lymphadenopathy. Read More

    Evaluation of ThyroSeq v2 performance in thyroid nodules with indeterminate cytology.
    Endocr Relat Cancer 2017 Mar 19;24(3):127-136. Epub 2017 Jan 19.
    Department of Head and Neck-Endocrine OncologyH. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pretest risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Center from September 2014 to April 2016, in light of the new diagnostic criteria for non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Our study included 182 patients (76% female) with 190 ITNs consecutively tested with ThyroSeq v2. Read More

    Thyroid cancer after hysterectomy on benign indications: Findings from an observational cohort study in Sweden.
    Int J Cancer 2017 Apr 3;140(8):1796-1801. Epub 2017 Feb 3.
    The Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    To investigate the association between hysterectomy and thyroid cancer subtypes based on histopathology. They did a nationwide, population-based, cohort study from 1973 to 2009 in Sweden. All women above 18 years of age during the period between January 1, 1973 and December 31, 2009 from the Register of Population (n = 5. Read More


    Cribriform adenocarcinoma of the soft palate with multiple lymph node metastasis and long-term follow-up.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Nov 1. Epub 2016 Nov 1.
    Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas, Brazil.
    Introduction: Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a recently described entity, with most cases previously published as polymorphous low-grade adenocarcinoma (PLGA). Typical cases share some main characteristics, such as oral sites (mainly tongue), regional lymph node metastasis, and morphology resembling solid and follicular variants of papillary thyroid carcinoma.

    Objective: To present a CATMSG and emphasize the importance of reclassifying PLGAs with unusual behavior. Read More

    Comprehensive screening for PD-L1 expression in thyroid cancer.
    Endocr Relat Cancer 2017 Feb;24(2):97-106
    Division of Endocrinology and MetabolismDepartment of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    PD-L1 expression is being considered a potential biomarker for response of anti-PD-1 or anti-PD-L1 agents in various tumors. The reported frequency of PD-L1 positivity varies in thyroid carcinomas, and multiple factors may contribute to the variability in PD-L1 positivity. We evaluated the PD-L1 expression in various thyroid cancers on a large scale. Read More

    Multiple metastasis of follicular variant of papillary thyroid carcinoma coexistent with malignant melanoma.
    Korean J Intern Med 2017 Jan 16. Epub 2017 Jan 16.
    Division of Endocrinology and Metabolism, Department of Internal Medicine and Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.

    Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls.
    Eur J Med Genet 2017 Mar 9;60(3):178-184. Epub 2017 Jan 9.
    Service de Biochimie « Hormonologie-Métabolisme-Nutrition & Oncologie », Centre de Biologie Pathologie, Centre Hospitalier Régional & Universitaire, F-59037 Lille Cedex, France. Electronic address:
    A heterozygous germline variant in the HABP2 gene c.1601G > A (p.Gly534Glu), which negatively impacts its tumor suppressive activity in vitro, has been described in 4-14% of kindreds of European-American ancestry with familial papillary thyroid carcinoma (fPTC). Read More

    The association of papillary thyroid cancer with microcalcification in thyroidnodules with indeterminate cytology based on fine-needle aspiration biopsy.
    Turk J Med Sci 2016 Dec 20;46(6):1719-1723. Epub 2016 Dec 20.
    Department of General Surgery, Faculty of Medicine, İstanbul Medeniyet University Göztepe Education and Research Hospital, İstanbul, Turkey.
    Background/aim: Microcalcifications are generally accepted as highly specific for thyroid malignancy, especially for papillary thyroid carcinoma (PTC). The aim of this study was to determine the significance of microcalcification within nodules that were classified as being of “indeterminate cytology” (IC) according to fine-needle aspiration biopsy.

    Materials And Methods: Patients who underwent thyroidectomy between January 2010 and 2013 were included in the study. Read More

    Evaluation of a Two-Year Routine Application of Molecular Testing of Thyroid Fine-Needle Aspirations Using a Seven-Gene Panel in a Primary Referral Setting in Germany.
    Thyroid 2017 Feb 7. Epub 2017 Feb 7.
    25 Division of Endocrinology, Department of Medicine, and Departments of Oncology, and Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary , Calgary, Canada .
    Background: Major differences with respect to the diagnostic performance of a "ruling in" approach in the presurgical diagnosis of indeterminate thyroid fine-needle aspirations (FNAs) have been reported. Therefore, the aim of this prospective multicenter study was to investigate the specific diagnostic impact of mutation testing using a seven-gene panel in a routine primary referral setting analyzing FNAs from endocrinology and nuclear medicine practices in Germany.

    Methods: RNA and DNA was extracted from 564 routine air-dried FNA smears obtained from 64 physicians and cytologically graded by one experienced cytopathologist. Read More

    Detecting N-RAS Q61R Mutated Thyroid Neoplasias by Immunohistochemistry.
    Endocr Pathol 2017 Mar;28(1):71-74
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
    Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled. Read More

    Radioiodine as an adjuvant therapy and its role in follow-up of differentiated thyroid cancer.
    J Cancer Res Ther 2016 Jul-Sep;12(3):1109-1113
    Department of Nuclear Medicine and PET CT, Amrita Institute of Medical Sciences, Cochin, Kerala, India.
    Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. Read More

    Thyroid Nodule Size at Ultrasound as a Predictor of Malignancy and Final Pathologic Size.
    Thyroid 2017 Feb 3. Epub 2017 Feb 3.
    1 Department of Pathology, The University of Chicago Medicine , Chicago, Illinois.
    Background: Thyroid-related mortality has remained constant despite the increasing incidence of thyroid carcinoma. Most thyroid nodules are benign; therefore, ultrasound and fine needle aspiration (FNA) are integral in cancer screening. We hypothesize that increased nodule size at ultrasound does not predict malignancy and correlation between nodule size at ultrasound and pathologic exam is good. Read More

    Primary Thyroid Carcinoma with Low-Risk Histology and Distant Metastases: Clinicopathologic and Molecular Characteristics.
    Thyroid 2017 Feb 1. Epub 2017 Feb 1.
    1 Department of Pathology, Memorial Sloan-Kettering Cancer Center , New York, New York.
    Background: Distant metastases (DM) are a rare occurrence in well-differentiated thyroid carcinoma. The aim of this study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low-risk histology that develop DM.

    Methods: A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion, or significant lymph node metastases but exhibiting DM. Read More

    [Thyroid carcinoma, ten-years file].
    Rozhl Chir 2016 ;95(11):394-397
    Introduction: Even though thyroid carcinoma has, in general, a good prognosis and low mortality rate, its incidence, especially the incidence of early forms of the disease has been growing.

    Method: Retrospective analysis of the file of surgeries of documented thyroid carcinoma within the years of 2006-2015.

    Results: Thyroid carcinoma was recorded in 145 of 1820 patients operated for thyreopathy (8%); microcarcinoma (<10mm) was recorded in 64 cases (44. Read More

    Rare Intradural Cervical Nerve Root Metastasis of Follicular Thyroid Carcinoma.
    Cureus 2016 Nov 24;8(11):e898. Epub 2016 Nov 24.
    Department of Neurosurgery, University of California Riverside.
    Intradural extramedullary nerve root metastasis is extremely unusual with only a handful of cases reported, and it presents most commonly in the thoracic and lumbosacral regions. We report the first case of metastasis to a ventral cervical nerve root in a patient with low-grade follicular thyroid carcinoma thought to be in remission for several years. Histopathology demonstrated malignant transformation and invasion of the nerve root. Read More

    Prevalence of Contralateral Tumors in Patients with Follicular Variant of Papillary Thyroid Cancer.
    J Am Coll Surg 2016 Dec 23. Epub 2016 Dec 23.
    Department of Surgery, Brigham and Women's Hospital, Boston, MA. Electronic address:
    Background: Thyroid lobectomy alone is being performed increasingly for patients with encapsulated follicular variant of papillary thyroid carcinoma (fvPTC). However, the prevalence of contralateral disease in these patients is unknown. We investigated the presence of synchronous disease in fvPTC to improve decision making about the extent of surgical resection and need for surveillance. Read More

    Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer.
    Oncotarget 2017 Jan;8(4):5761-5773
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
    PAX8-PPARG fusion protein (PPFP) results from a t(2;3)(q13;p25) chromosomal translocation, is found in 30% of follicular thyroid carcinomas, and demonstrates oncogenic capacity in transgenic mice. A PPARG ligand, pioglitazone, is highly therapeutic in mice with PPFP thyroid cancer. However, only limited data exist to characterize the binding sites and oncogenic function of PPFP, or to explain the observed therapeutic effect of pioglitazone. Read More

    Higher preablative serum thyroid-stimulating hormone level predicts radioiodine ablation effectiveness in patients with differentiated thyroid carcinoma.
    Nucl Med Commun 2017 Mar;38(3):222-227
    aDepartment of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria bDepartment of Nuclear Medicine, University of Kwa-Zulu Natal, Durban, South Africa.
    Introduction: Radioiodine ablation of remnant thyroid tissue is an important adjuvant therapy of differentiated thyroid carcinoma (DTC) after thyroidectomy. Elevated serum thyroid-stimulating hormone (TSH) level is necessary for successful ablation. The optimum level of serum TSH level necessary for successful radioiodine ablation of well-DTC is, however, yet to be defined. Read More

    Effect of the micronutrient iodine in thyroid carcinoma angiogenesis.
    Aging (Albany NY) 2016 Dec;8(12):3180-3184
    Laboratory of human thyroid cancers preclinical and translational research, Division of Experimental Pathology, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
    Iodide is a micronutrient essential for thyroid hormone production. The uptake and metabolism of iodide by thyrocytes is crucial to proper thyroid function. Iodide ions are drawn into the thyroid follicular cell via the sodium-iodide symporter (NIS) in the cell membrane and become integrated into tyrosyl residues to ultimately form thyroid hormones. Read More

    Unusual Uptake of Prostate Specific Tracer (68)Ga-PSMA-HBED-CC in a Benign Thyroid Nodule.
    Nucl Med Mol Imaging 2016 Dec 22;50(4):344-347. Epub 2016 Mar 22.
    Department of Nuclear Medicine, A.I.I.M.S, New Delhi, India.
    (68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease. Read More

    [Advances in studies of the genes related to thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Dec;51(12):951-955
    Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
    Thyroid carcinoma (TC) is the most common endocrine cancer and its incidence has been increasing globally over the past decades. With the development of the genetic technology, more and more evidences showed that many genes affect the biological behaviors of TC, making sense to early diagnosis, predicting the prognosis and targeted therapy for TC. BRAF mutation is specific to papillary thyroid carcinoma (PTC). Read More

    Most Thyroid Cancers Detected by Sonography Lack Intranodular Vascularity on Color Doppler Imaging: Review of the Literature and Sonographic-Pathologic Correlations for 698 Thyroid Neoplasms.
    J Ultrasound Med 2016 Dec 1. Epub 2016 Dec 1.
    Lenox Hill Radiology, New York, New York, USA.
    Objectives: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation.

    Methods: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. Read More

    Preoperative serum thyroglobulin and changes in serum thyroglobulin during TSH suppression independently predict follicular thyroid carcinoma in thyroid nodules with a cytological diagnosis of follicular lesion.
    Endocr Res 2016 Dec 12:1-9. Epub 2016 Dec 12.
    a Division of Endocrinology and Metabolism, Department of Internal Medicine , Soonchunhyang University Hospital, Soonchunhyang University College of Medicine , Seoul , Korea.
    Background: Fine-needle aspiration biopsy (FNAB) cannot distinguish a follicular thyroid carcinoma (FTC) from a follicular adenoma in follicular lesions. We designed this study to determine whether the preoperative thyroglobulin (Tg) and change in serum Tg during thyroid-stimulating hormone (TSH) suppression can predict FTC in thyroid nodules with a cytological diagnosis of follicular lesion.

    Methods: Among 854 patients who underwent thyroid surgery, the 198 patients who presented with thyroid nodules with a cytological diagnosis of follicular lesion were analyzed. Read More

    Micro-Raman spectroscopic study of thyroid tissues.
    Photodiagnosis Photodyn Ther 2016 Dec 5. Epub 2016 Dec 5.
    Laboratory of Biomedical Vibrational Spectroscopy, Institute for Research and Development (IP&D), Universidade do Vale do Paraíba (UniVap), Av. Shishima Hifumi, 2911, Urbanova, São José dos Campos, 12244-000, São Paulo (SP), Brazil. Electronic address:
    Thyroid carcinomas are the most common endocrine malignancy. Inconclusive results for the analysis of malignancies are an issue in the diagnosis of thyroid carcinomas; 20% of thyroid cancer diagnoses are indeterminate or suspicious, resulting in a surgical procedure without immediate need. The use of Raman spectroscopy may help improve the diagnosis of thyroid carcinoma. Read More

    Surgical management of parapharyngeal space tumors: The role of cervical and lateral skull base approaches.
    Ear Nose Throat J 2016 Dec;95(12):E1-E6
    Department of Otorhinolaryngology, Saudi German Hospital Dubai, Hessa St. 331 West, PO Box 391093, Dubai, UAE.
    We conducted a retrospective study to analyze the role of the cervical and lateral skull base approaches in the surgical excision of parapharyngeal space (PPS) tumors. Our study population was made up of 34 patients-15 males and 19 females, aged 13 to 73 years (mean: 50.6)-who had presented to us with a PPS tumor during a 9-year period. Read More

    The total number of tissue blocks per centimetre of tumor significantly correlated with the risk of distant metastasis in patients with minimally invasive follicular thyroid carcinoma.
    Endocrine 2017 Feb 7;55(2):496-502. Epub 2016 Dec 7.
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, SAR, China.
    Background: Given that careful histological examination plays a pivotal role in follicular thyroid carcinoma categorization, we hypothesize that the number of blocks taken at initial specimen review may be associated with survival outcomes of patients initially diagnosed with minimally invasive follicular thyroid carcinoma.

    Methods: A total of 162 patients with confirmed minimally invasive follicular thyroid carcinoma were analyzed. The number of tissue blocks taken from each patient was recorded and the number of blocks per each centimeter of tumor was calculated. Read More

    1 OF 171