9,068 results match your criteria Thyroid Follicular Carcinoma


Surgical management of follicular thyroid carcinoma in children and adolescents: A study of 30 cases.

J Pediatr Surg 2018 May 29. Epub 2018 May 29.

Pediatric and Adolescent Surgery Division, University of Pisa, Italy.

Background/purpose: The purpose of the study is to describe the anatomoclinical, diagnostic, therapeutic and prognostic aspects of pediatric follicular thyroid carcinoma (FTC) in order to choose the best therapeutic strategy.

Methods: Our study includes patients ≤18 years old surgically treated for FTC in four Italian Pediatric Surgery Centers from January 2000 to March 2017. The collected data were compared with those of 132 patients matched for age with a histological diagnosis of papillary thyroid carcinoma (PTC) surgically treated in the same institutions during the same period and with the data of patients diagnosed with FTC found in the literature; p-values <0. Read More

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A Case of Functional Metastatic Follicular Thyroid Carcinoma that Presented with Hip Fracture and Hypercalcemia.

Adv Biomed Res 2018 29;7:92. Epub 2018 May 29.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Thyroid follicular cancers are one of the thyroid gland cancers. This cancer can lead to metastases to various areas of the body. We describe a patient with thyroid follicular carcinoma who after total thyroidectomy had severe hypercalcemia, increased creatinine, and thyrotoxicosis due to extensive bone metastases. Read More

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Correction to: Application of Strict Criteria for Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and Encapsulated Follicular Variant Papillary Thyroid Carcinoma: a Retrospective Study of 50 Tumors Previously Diagnosed as Follicular Variant PTC.

Endocr Pathol 2018 Jun 19. Epub 2018 Jun 19.

Department of Pathology, Emory University Hospital Midtown, 550 Peachtree St. NE, Davis-Fischer Building Suite 1314-A, Atlanta, GA, 30308, USA.

In the original publication, the author name Kimberly Point du Jour was incorrectly captured. The correct Given name should be Kimberly and the Family name should be Point du Jour. The correct author name is presented in this correction article. Read More

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Lytic Skull Metastasis from Follicular Carcinoma of Thyroid: A Case Diagnosed on Cytology.

J Family Community Med 2018 May-Aug;25(2):129-130

Department of Pathology and Laboratory, Dr. Doda's Diagnostics and Healthcare, New Delhi, India.

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Spectroscopic analysis of normal and neoplastic (WI-FTC) thyroid tissue.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Jun 7;204:18-24. Epub 2018 Jun 7.

Center for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, PL-35959 Rzeszow, Poland.

Thyroid cancer holds the first place of the malignant tumors of the endocrine system. One of the less common thyroid cancers is follicular thyroid carcinoma (FTC), which is very difficult to diagnose because it gives the same image as adenoma, which is benign. Certainty of the diagnosis is gained only when FTC gives metastases. Read More

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Proteomic analysis reveals differential protein expression in variants of papillary thyroid carcinoma.

EuPA Open Proteom 2017 Dec 13;17:1-6. Epub 2017 Sep 13.

Acibadem Mehmet Ali Aydinlar University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey.

Introduction: Fine Needle Aspiration Biopsy (FNAB) allows the cytological differentiation of benign and malignant thyroid nodules. However, the method itself is not adequate in determining some cases. For example, the diagnosis of Follicular Variant Papillary Thyroid Carcinoma (FV-PTC) can be challenging. Read More

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December 2017
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Frequent and Rare HABP2 Variants Are Not Associated with Increased Susceptibility to Familial Nonmedullary Thyroid Carcinoma in the Spanish Population.

Horm Res Paediatr 2018 Jun 12:1-11. Epub 2018 Jun 12.

Thyroid Molecular Laboratory, Institute for Medical and Molecular Genetics (INGEMM), IdiPAZ, La Paz University Hospital, Universidad Autónoma de Madrid, Madrid, Spain.

Background/aims: A genomic HABP2 variant was proposed to be responsible for familial nonmedullary thyroid carcinoma (FNMTC). However, its involvement has been questioned in subsequent studies. We aimed to identify genetic HABP2 mutations in a series of FNMTC patients and investigate their involvement in the disease. Read More

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Hypermetabolic Hurthle Cell Adenoma on F-FDG PET/CT.

Mol Imaging Radionucl Ther 2018 Jun;27(2):96-98

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Department of Pathology, Lahore, Pakistan.

Thyroid incidentalomas are frequently reported on F-FDG PET/CT scan. High risk of malignancy is thought to be associated with increased metabolic activity and high standardized uptake value. Likewise, thyroid nodules with focal FDG avidity have a higher potential to be malignant. Read More

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Outcomes and prognostic factors in thyroid cancer patients with cranial metastases: A retrospective cohort study of 4,683 patients.

Int J Surg 2018 Jun 5;55:182-187. Epub 2018 Jun 5.

Department of Surgery, Chang Gung Memorial Hospital Linkou Branch, Chang Gung University, No. 5, Fuxing St, Guishan Dist, Taoyuan City 333, Taiwan. Electronic address:

Background: Cranial metastasis of thyroid cancer is rare. The aim of this study was to analyse the clinical characteristics, treatments and outcomes of thyroid cancer patients with cranial metastasis and to identify the associated prognostic factors.

Materials And Methods: Between January 1977 and August 2017, a total of 4683 patients were histologically confirmed to have thyroid cancer. Read More

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Management of differentiated thyroid carcinomas.

Acta Otorrinolaringol Esp 2018 Jun 4. Epub 2018 Jun 4.

Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España; Instituto de Investigación Sanitaria del Principado de Asturias, IUOPA, Universidad de Oviedo, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Oviedo, Asturias, España.

Introduction And Objectives: Radioiodine is the principal treatment for differentiated thyroid carcinomas. The aim of this study is to present our experience in the management of these tumours.

Material And Method: We present a retrospective study of 55 patients operated for differentiated thyroid carcinoma in our hospital between 2007 and 2011. Read More

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Ultrasonographic Features of Papillary Thyroid Carcinomas According to Their Subtypes.

Front Endocrinol (Lausanne) 2018 8;9:223. Epub 2018 May 8.

Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.

Background: The ultrasonographic characteristics and difference for various subtypes of papillary thyroid carcinoma (PTC) are still unclear. The aim of this study was to compare the ultrasonographic features of PTC according to its subtype in patients undergoing thyroid surgery.

Methods: In total, 140 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery between January 2016 and December 2016 were included. Read More

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Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification?

Acta Cytol 2018 Jun 1:1-8. Epub 2018 Jun 1.

Objectives: To assess the cytological findings of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), conventional papillary thyroid carcinomas (C-PTC), and invasive follicular variants of papillary thyroid carcinomas (IFV-PTC) to determine if there are cytological differences between groups.

Study Design: We have reviewed all thyroid fine-needle aspiration cytology samples diagnosed between 2000 and 2017. We have included all NIFTP cases (n = 6) and randomly selected cases of C-PTC (n = 14) and IFV-PTC (n = 8). Read More

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[Recovery rate in differentiated thyroid cancer. Experiences of one of the Hungarian clinical centers].

Orv Hetil 2018 Jun;159(22):878-884

Klinikai Központ, I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Ifjúság útja 13., 7624.

Introduction And Aim: The worldwide incidence of differentiated thyroid cancer (DTC) has markedly increased during the last few decades. According to the international guidelines, principles of DTC management are in transformation. The aim of our work was to evaluate patients' current likelihood of recovery. Read More

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Diagnostic value of CD56 immunohistochemistry in thyroid lesions.

Int J Biol Markers 2018 May;33(2):161-167

2 Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul - Republic of Korea.

Purpose: The present study aimed to evaluate the diagnostic roles of CD56 immunohistochemistry in differentiating various thyroid lesions.

Methods: A meta-analysis was performed to evaluate the rate of loss of CD56 immunohistochemistry expression from 13 eligible studies regarding various thyroid lesions, including papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. To confirm the value of CD56 immunohistochemistry in differentiating various thyroid lesions, a diagnostic test accuracy review was conducted. Read More

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Clinicopathological profile of papillary carcinoma of thyroid: A 10-year experience in a tertiary care institute in North Karnataka, India.

Indian J Cancer 2017 Jul-Sep;54(3):514-518

Department of Pathology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.

Context: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy accounting for 80% of the thyroid cancers. Many histopathologic variants of PTC have been recognized, and few of these are of prognostic significance. The studies on clinicopathological features of PTC and its variants are so far seldom reported in India. Read More

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High Ki-67 index in fine needle aspiration cytology of follicular thyroid tumors is associated with increased risk of carcinoma.

Endocrine 2018 May 23. Epub 2018 May 23.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Purpose: Preoperative distinction of follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA) is a diagnostic challenge. Our aim was to investigate whether the Ki-67 proliferation index in fine needle aspiration material can contribute to the diagnosis of FTC.

Methods: We analyzed retrospectively cytological Ki-67 index determined in routine clinical setting and clinical data for 61 patients with FTC, 158 patients with FTA and 15 patients with follicular tumor of uncertain malignant potential (FT-UMP) surgically treated and diagnosed by histopathology at Karolinska University Hospital 2006-2017 (Cohort A). Read More

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Thyroid follicular carcinoma-like renal tumor: A case report and literature review.

Medicine (Baltimore) 2018 May;97(21):e10815

Department of Pathology, Tianjin Medical University General Hospital.

Rationale: Thyroid follicular carcinoma-like renal tumor (TFCLRT) is a rare primary renal epithelial tumor that was first reported in 2006. We report a case diagnosed of TFCLRT by us to observe the pathological feature and analyze comparatively the clinical and pathologic characteristics with all cases of reviewed literatures.

Patient Concerns: A 54-year-old female patient had the urinary frequency with the symptom of right flank pain with a history of more than half a year of hypertension and received uterine fibroid resection 12 years ago. Read More

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Subcentimeter noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).

Histopathology 2018 May 23. Epub 2018 May 23.

Santa Casa de Belo Horizonte, Minas Gerais, Brazil.

Recently, it was proposed that the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (noninvasive E-FVPTC) start to be called "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). As the original cohort of 109 patients with NIFTP studied by the consensus conference included only tumors which were equal or more than 1 cm in size, the consensus diagnostic criteria of NIFTP did not explicitly address subcentimeter lesions. In fact, in a recent review published in this journal, Hung & Barletta recognize that there are a few published subcentimetre NIFTP in the literature. Read More

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High expression of CD10 in anaplastic thyroid carcinomas.

Histopathology 2018 May 23. Epub 2018 May 23.

Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.

Aims: CD10 is an endopeptidase that degrades variable bioactive peptides in extra-cellular matrix. In addition to the enzymatic degradation, it affects multiple intra-cellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. Read More

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Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients.

Neoplasma 2018 Mar;65(3):436-440

Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, China.

Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto's thyroiditis(HT), nodular goiter(NG), Follicular adenoma(FA) and other types. However, the function of these diseases in PTC tumorigenesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Read More

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March 2018
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Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway.

Mod Pathol 2018 May 21. Epub 2018 May 21.

i3S Instituto de Investigação e Inovação em Saúde, Porto, Portugal.

Cribriform-morular variant of thyroid carcinoma is classically associated with familial adenomatous polyposis but, it can also occur as a sporadic neoplasm. This neoplasm is much more frequently observed in women than in men (ratio of 61:1). In familial adenomatous polyposis patients, tumors are generally multifocal and/or bilateral (multinodular appearance), whereas in the sporadic cases tumors tend to occur as single nodules. Read More

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Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium/iodide symporter (SLC5A5) mutation in a family of Shih-Tzu dogs.

Domest Anim Endocrinol 2018 Apr 24;65:1-8. Epub 2018 Apr 24.

Laboratory of Comparative Medical Genetics and Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.

An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. Read More

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Transoral videolaryngoscopic surgery for papillary carcinoma arising in lingual thyroid.

Auris Nasus Larynx 2018 Oct;45(5):1127-1129

Department of Otolaryngology-Head & Neck Surgery, Kobe University Hospital, Kobe, Japan.

Carcinoma arising in lingual thyroid is an extremely rare entity accounting for only 1% of all reported ectopic thyroids. Here, we report a case of carcinoma arising in lingual thyroid, which has been successfully managed by transoral resection and bilateral neck dissections. A lingual mass 4-cm in diameter with calcification was incidentally detected by computed tomography at medical check-up. Read More

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October 2018

[Skull base metastasis from differentiated thyroid carcinoma: 3 cases report and review of literature].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;31(11):881-884

Skull base metastasis from differentiated thyroid carcinoma (DTC), including papillary and follicular thyroid carcinoma, is a rare manifestation and easily misdiagnosed. In this study, we reported three cases whose initial clinical presentation was skull base metastasis complaints with the presence of silent primary sites. Based on the thyroid ultrasound and histopathology (identifying skull base and primary thyroid tumor), the final diagnoses of DTC metastasis to skull base were confirmed. Read More

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Risk factors for central neck lymph node metastases in follicular variant vs. classic papillary thyroid carcinoma.

Endocrine 2018 May 16. Epub 2018 May 16.

Division of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario "A. Gemelli", Università Cattolica del Sacro Cuore, Rome, Italy.

Purpose: Histological variants of papillary thyroid carcinoma (PTC) have been advocated as possible risk factors for central neck nodal metastases (CNM). A lower incidence of CNM in follicular variant of papillary thyroid carcinoma (fvPTC) when compared with classic PTC (cPTC) has been observed. We aimed to compare risk factors for CNM in patients with fvPTC and cPTC. Read More

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Thyroid FNAC: Causes of false-positive results.

Cytopathology 2018 May 16. Epub 2018 May 16.

IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

In this paper, we aim to focus on false positive results in the evaluation of thyroid aspirations, covering cystic, inflammatory, follicular and oncocytic lesions, papillary carcinoma, and medullary carcinoma of thyroid. The recently described entity noninvasive follicular thyroid neoplasm with papillary-like nuclear features is also discussed detailing the impact of its introduction on the sensitivity and specificity of thyroid FNA, as well as the use of molecular tests for diagnostics. Medicolegal issues in relation to current practice in English law are also described. Read More

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Radioiodine therapy in differentiated thyroid cancer - a matter of controversy - PRO Radioiodine.

J Nucl Med 2018 May 10. Epub 2018 May 10.

Universitätsklinikum Köln.

Radioiodine therapy is a matter of controversy as different opinions exist towards its use in patients with differentiated thyroid carcinoma. The following article sheds light on different opinions and explains why the authors advocate the use of radioiodine therapy not only in high-risk patients. In comparison to other malignancies differentiated thyroid carcinoma has a different tumor biology due to its usually slow growth pattern. Read More

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Use of the Thyroid Imaging, Reporting, and Data System (TI-RADS) scoring system for the evaluation of subcentimeter thyroid nodules.

Cancer Cytopathol 2018 May 7. Epub 2018 May 7.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: The American Thyroid Association (ATA) recommends fine-needle aspiration (FNA) biopsy of nodules measuring >1.5 cm with low-suspicion sonographic patterns or >1.0 cm with high/intermediate-suspicion features. Read More

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Programmed death-ligand 1 expression by digital image analysis advances thyroid cancer diagnosis among encapsulated follicular lesions.

Oncotarget 2018 Apr 13;9(28):19767-19782. Epub 2018 Apr 13.

Alex and Simona Shnaider Research Laboratory in Molecular Oncology, Sinai Health System, Toronto, ON, Canada.

Recognition of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) that distinguishes them from invasive malignant encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) can prevent overtreatment of NIFTP patients. We and others have previously reported that programmed death-ligand 1 (PD-L1) is a useful biomarker in thyroid tumors; however, all reports to date have relied on manual scoring that is time consuming as well as subject to individual bias. Consequently, we developed a digital image analysis (DIA) protocol for cytoplasmic and membranous stain quantitation (ThyApp) and evaluated three tumor sampling methods [Systemic Uniform Random Sampling, hotspot nucleus, and hotspot nucleus/3,3'-Diaminobenzidine (DAB)]. Read More

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Skeletal muscle metastases from papillary and follicular thyroid carcinomas: An extensive review of the literature.

Authors:
Leszek Herbowski

Oncol Lett 2018 May 8;15(5):7083-7089. Epub 2018 Mar 8.

Neurosurgery and Neurotraumatology Department, District Hospital, 71-455 Szczecin, Poland.

Skeletal muscle metastasis of papillary or follicular thyroid cancer (PTC/FTC) is a rare finding; only 11 cases of skeletal muscle PTC or FTC metastasis have been included in medical literature reviews. The aim of this study was to identify all published cases of PTC and FTC muscle metastases and derive the true incidence of this malignancy. The probability of detecting the skeletal muscle metastasis of PTC and FTC was calculated based on epidemiological data. Read More

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Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology.

J Clin Endocrinol Metab 2018 May 2. Epub 2018 May 2.

Yale Endocrine Neoplasia Laboratory, Yale School of Medicine, New Haven, CT.

Context: Follicular thyroid cancer (FTC) is classified into minimally invasive (miFTC), encapsulated angioinvasive (eaFTC), and widely invasive (wiFTC) subtypes, according to the 2017 World Health Organization (WHO) guidelines. The genetic signatures of these subtypes may be crucial for diagnosis, prognosis, and treatment, but have not been described.

Objective: Identify and describe the genetic underpinnings of subtypes of follicular thyroid cancer. Read More

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May 2018
2 Reads

Management of highly differentiated thyroid follicular carcinoma of ovarian origin with a minimally invasive approach.

Gynecol Oncol Rep 2018 May 19;24:87-89. Epub 2018 Apr 19.

Division of Gynecologic Oncology, Brooke Army Medical Center, 3551 Roger Brooke Drive, San Antonio, TX 78234, United States.

•Peritoneal strumosis is highly differentiated thyroid follicular carcinoma of ovarian origin.•Minimally invasive surgical techniques for peritonectomy can resect extra-ovarian disease.•Multi-disciplinary collaboration allowed avoidance of thyroid ablation and thyroidectomy. Read More

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Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors.

Hum Pathol 2018 Apr 30. Epub 2018 Apr 30.

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Follicular-patterned tumors of the thyroid gland are characterized by a predominantly follicular growth pattern. They frequently harbor RAS mutations, not BRAF mutations. Technological advances in molecular testing have discovered novel RAS-type mutations. Read More

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The Feasibility of Thoracoscopic Left Pneumonectomy.

Authors:
Hao Xu Linyou Zhang

Thorac Cardiovasc Surg 2018 May 1. Epub 2018 May 1.

Department of Thoracic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Objective:  In this study, we describe our experience with video-assisted thoracoscopic surgery (VATS) left pneumonectomy as a treatment for advanced malignant and benign diseases.

Methods:  Patients who underwent VATS left pneumonectomy in our clinic between October 2013 and August 2017 were retrospectively evaluated. VATS pneumonectomy was successfully completed in 46 patients. Read More

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May 2018
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Impact of Nodule Size on Malignancy Risk Differs according to the Ultrasonography Pattern of Thyroid Nodules.

Korean J Radiol 2018 May-Jun;19(3):534-541. Epub 2018 Apr 6.

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

Objective: To test whether the impact of thyroid-nodule size on the malignancy risk differs according to the ultrasonography (US) patterns of nodules.

Materials And Methods: This study is a post hoc analysis using data from the Thyroid Imaging Reporting and Data System (TIRADS) multicenter retrospective study which included 2000 consecutive thyroid nodules (≥ 1 cm) with final diagnoses. A total of 2000 consecutive thyroid nodules from 1802 patients (1387 women and 613 men; mean age, 51. Read More

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TIRADS score is of limited clinical value for risk stratification of indeterminate cytological results.

Eur J Endocrinol 2018 Jul 27;179(1):13-20. Epub 2018 Apr 27.

Thyroid and Endocrine TumorsInstitute of Endocrinology, Pitié Salpêtrière Hospital, Pierre and Marie Curie University, Paris, France.

Context: Thyroid nodules with cytological indeterminate results represent a daily and recurrent issue for patient management.

Objective: The primary aim of our study was to determine if TIRADS (Thyroid Imaging Reporting and Data System) could be used to stratify the malignancy risk of these nodules and to help in their clinical management. Secondary objective was to estimate if this risk stratification would change after reclassification of encapsulated non-invasive follicular variant of papillary carcinomas (FVPTC) as non-invasive follicular thyroid neoplasm (NIFTP). Read More

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Thrombosis in Thyroid Cancer.

Int J Endocrinol Metab 2018 Jan 31;16(1):e57897. Epub 2017 Oct 31.

MD, Endocrine Section, MedStar Washington Hospital Center, Washington, DC, 20010.

Background: The number of studies on venous thromboembolism (VTE) and thyroid cancer is very scarce and existing data are contradictory. This paper reviews VTE in thyroid cancer.

Methods: The following words were used for a comprehensive literature review using MEDLINE database: Blood coagulation factors; thyroid hormones; blood coagulation tests; venous thromboembolism; receptors thyroid hormone; hemostasis; fibrinolysis; bleeding; blood coagulation disorders; thyroid neoplasms; Thyroid cancer, papillary; Thyroid cancer, follicular; Thyroid carcinoma, anaplastic; Thyroid cancer, Hurthle cell; Familial medullary thyroid carcinoma; venous thrombosis; Pulmonary embolism; Blood coagulation factors. Read More

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January 2018

Molecular Profile of Advanced Thyroid Carcinomas by Next-Generation Sequencing: Characterizing Tumors Beyond Diagnosis for Targeted Therapy.

Mol Cancer Ther 2018 Apr 25. Epub 2018 Apr 25.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Next-generation sequencing (NGS) for molecular diagnostics allows simultaneous testing of activating oncogenes and tumor suppressor mutations in multiple signal pathways. Extended mutational profiling of advanced thyroid cancers may enhance considerations for targeted therapies. We analyzed clinically derived molecular profiling of 216 patients with advanced thyroid carcinoma using NGS (Ion Torrent Personal Genome Machine) from April 2012 to February 2014. Read More

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Value of cytokeratin-19, Hector Battifora mesothelial-1 and galectin-3 immunostaining in the diagnosis of thyroid neoplasms.

J Lab Physicians 2018 Apr-Jun;10(2):200-207

Department of Endocrinology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Background: Diagnosis of types and aggressiveness of thyroid cancers is difficult. The "gold standard" in diagnosis is using routine hematoxylin and eosin staining. Several markers have been investigated for differentiating them among which cytokeratin-19 (CK-19), Hector Battifora mesothelial cell (HBME-1), and galectin-3 are found to be most commonly used. Read More

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April 2018
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Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma.

Clin Nucl Med 2018 Jul;43(7):482-485

Gastroenterological Surgery 2, Nagoya University Hospital, Nagoya, Japan.

Background: Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. Read More

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Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer.

J Bioenerg Biomembr 2018 Aug 23;50(4):263-270. Epub 2018 Apr 23.

Department of Endocrinology, The Third People's Hospital of Guangxi Zhuang Autonomous Region, Riverside Hospital of Guangxi Zhuang Autonomous Region, Heti Road 85, Qingxiu District, Nanning, 530021, China.

The clinical management of anaplastic thyroid carcinoma and follicular thyroid carcinoma is challenging and requires an alternative therapeutic strategy. Although atovaquone is an FDA-approved anti-malarial drug, studies has recently demonstrated its anti-cancer activities. In line with these efforts, our study shows that atovaquone is an attractive candidate for thyroid cancer treatment. Read More

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August 2018
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Morphology combined with ancillary techniques: An algorithm approach for thyroid nodules.

Cytopathology 2018 Apr 23. Epub 2018 Apr 23.

Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario "Agostino Gemelli" School of Medicine, Rome, Italy.

Introduction: Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques, including immunocytochemistry (ICC) and molecular testing, contributes to a better definition of the risk of malignancy (ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (ie, BRAF ), micro RNA analysis is proposed for FNs. Read More

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April 2018
1 Read

Follicular Thyroid Carcinoma in a Country of Endemic Iodine Deficiency (1994-2013).

J Thyroid Res 2018 25;2018:6516035. Epub 2018 Feb 25.

Department of Pathology, Korle-Bu Teaching Hospital, P.O. Box 77, Korle-Bu, Accra, Ghana.

Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Read More

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February 2018

Histopathological pattern of thyroid diseases in Zaria: A 10-year review.

Niger Postgrad Med J 2018 Jan-Mar;25(1):37-42

Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.

Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens.

Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Read More

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TERT, HRAS, and EIF1AX Mutations in a Patient with Follicular Adenoma.

Thyroid 2018 Jun 18;28(6):815-817. Epub 2018 May 18.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University , Philadelphia, Pennsylvania.

Background: Molecular markers are increasingly used as diagnostic tools in the management of thyroid nodules. There is a paucity of studies evaluating the prevalence of molecular markers in benign lesions.

Patient Findings: A 68-year-old woman with hypothyroidism presented with a right thyroid nodule, which was atypia of undetermined significance on cytology. Read More

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Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation.

Surg Case Rep 2018 Apr 17;4(1):34. Epub 2018 Apr 17.

Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, 89-1 Enya, Izumo, Shimane, 693-8501, Japan.

Background: Carney complex (CNC) is a very rare disease. Although thyroid lesions are included in the diagnostic criteria for CNC, they are an infrequent occurrence.

Case Presentation: The patient was a 69-year-old woman who had undergone the removal of a left atrial myxoma 10 years earlier, at the age of 59. Read More

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April 2018
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Thyroid-Like Intrahepatic Cholangiocarcinoma: Report of a Case and Review of the Literature.

Int J Surg Pathol 2018 Apr 1:1066896918769381. Epub 2018 Apr 1.

1 Department of Pathology, Fuzhou General Hospital of PLA, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou City, Fujian Province, China.

Intrahepatic cholangiocarcinoma is a relatively uncommon malignant neoplasm. We recently encountered an unusual case of intrahepatic cholangiocarcinoma that histologically resembled a thyroid carcinoma. A thorough review of the English literature revealed only 2 similar cases that have been previously reported. Read More

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April 2018
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Positive Surgical Margins in Favorable-Stage Differentiated Thyroid Cancer.

Am J Clin Oncol 2018 Apr 16. Epub 2018 Apr 16.

Departments of Radiation Oncology.

Objective: The significance of positive margin in favorable-stage well-differentiated thyroid cancer is controversial. We report outcomes of positive-margin patients with a matched-pair comparison to a negative-margin group.

Materials And Methods: A total of 25 patients with classic-histology papillary or follicular carcinoma, total thyroidectomy +/- node dissection, stage T1-3N0-1bM0, positive surgical margin at primary site, adjuvant radioactive iodine (I-131), and age older than 18 years were treated between 2003 and 2013. Read More

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April 2018
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The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells.

J Cell Biochem 2018 Jul 16;119(7):6274-6287. Epub 2018 Apr 16.

Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey.

Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins. Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC-133, and papillary K1 thyroid carcinoma cells were rich in α-2,6, α-2,3, sialic acid, and α-1,6 fucose residues. Read More

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July 2018
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Role of Preablative Stimulated Thyroglobulin in Prediction of Nodal and Distant Metastasis on Iodine Whole-Body Scan.

Indian J Nucl Med 2018 Apr-Jun;33(2):93-98

Department of Endocrinology, Diabetes and Metabolism, Narayana Health City, Bengaluru, Karnataka, India.

Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (I WBS) in the management of low-to-intermediate-risk DTC patients. Read More

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