15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction.
Oncol Lett 2017 Apr 23;13(4):2569-2576. Epub 2017 Feb 23.
Graduate Institute of Life Sciences, National Defense Medical Center, Neihu, Taipei 114, Taiwan, R.O.C.
Metastasis is frequently observed in human follicular thyroid carcinoma. The present study investigated the peroxisome proliferator-activated receptor γ agonist, 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ2), and its effect on the migration of CGTH W-2 human thyroid carcinoma cells. 15d-PGJ2 decreased the survival rate of CGTH W-2 cells in a dose-dependent manner. Read More