Search our Database of Scientific Publications and Authors

I’m looking for a

    8926 results match your criteria Thyroid Follicular Carcinoma

    1 OF 179

    DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
    J Clin Endocrinol Metab 2018 Feb 21. Epub 2018 Feb 21.
    Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada.
    Context: Papillary thyroid carcinoma (PTC) is a common malignancy in adolescence and is molecularly and clinically distinct from adult PTC. Mutations in the DICER1 gene are associated with thyroid abnormalities including multinodular goitre and differentiated thyroid carcinoma.

    Objective: In this study, we sought to characterize the prevalence of DICER1 variants in paediatric PTC, specifically in tumours without conventional PTC oncogenic alterations. Read More

    Bone Metastases in Follicular Carcinoma of Thyroid.
    Indian J Otolaryngol Head Neck Surg 2018 Mar 19;70(1):10-14. Epub 2017 Jul 19.
    1Head and Neck Services, Tata Memorial Hospital, Mumbai, India.
    Though the association between follicular carcinoma and bone metastasis is well established, the site-wise distribution is not known. One hundred seventy-three patients of follicular carcinoma presenting between 2003 and 2011 were selected from 1093 patients of follicular lesions presenting at a single institution. Of these, 59 (34%) with bone metastasis were included in the study. Read More

    Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
    Cancer Microenviron 2018 Feb 17. Epub 2018 Feb 17.
    Departamento de Ciências Básicas da Saúde and Laboratório de Biologia Celular, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Prédio III, Sala 613, Porto Alegre, RS, CEP 90050-170, Brazil.
    The incidence of differentiated thyroid cancer has been increasing. Nevertheless, its molecular mechanisms are not well understood. In recent years, extracellular nucleotides and nucleosides have emerged as important modulators of tumor microenvironment. Read More

    In vitro studies of DNA damage and repair mechanisms induced by BNCT in a poorly differentiated thyroid carcinoma cell line.
    Radiat Environ Biophys 2018 Feb 16. Epub 2018 Feb 16.
    Radiobiology Department (CAC, CNEA), 1499 Gral Paz Av, Buenos Aires, Argentina.
    Boron neutron capture therapy (BNCT) for aggressive tumors is based on nuclear reaction [B (n, α)Li]. Previously, we demonstrated that BNCT could be applied for the treatment of undifferentiated thyroid carcinoma. The aim of the present study was to describe the DNA damage pattern and the repair pathways that are activated by BNCT in thyroid cells. Read More

    A rare case of ectopic papillary thyroid carcinoma transformed into squamous cell carcinoma.
    Pathol Int 2018 Feb 16. Epub 2018 Feb 16.
    Department of Diagnostic Pathology, Osaka Police Hospital.
    A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. Read More

    Thyroid carcinoma producing β-human chorionic gonadotropin shows different clinical behavior.
    Pathol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology, Shandong University School of Basic Medical Sciences, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.
    Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. Read More

    Risk of recurrence in a homogeneously managed pT3-differentiated thyroid carcinoma population.
    Langenbecks Arch Surg 2018 Feb 14. Epub 2018 Feb 14.
    Department of General, Visceral, and Endocrine Surgery, Pitié Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France.
    Background: International guidelines for the management of differentiated thyroid cancers are based on the 7th TNM classification: pT3 tumors are defined as differentiated thyroid cancers (DTCs) measuring more than 4 cm in their greatest dimension that are limited to the thyroid or any tumor with minimal extrathyroidal extension (ETE; sternothyroid muscle or perithyroid soft tissues). Differences in clinicohistological features and prognosis among patients with pT3 tumors remain controversial, and studies regarding pT3 subgroups are lacking.

    Objective: To analyze the prognosis of four subgroups of pT3 DTCs (papillary, PTC; or follicular, FTC). Read More

    Role of thyroid ultrasound combined with thyroglobulin in the diagnosis of postoperative recurrence of thyroid cancer.
    Minerva Endocrinol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Ultrasonography, Lihuili East Hospital, Ningbo Medical Center, Ningbo, China -
    Background: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice.

    Methods: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed. Read More

    BRAF and RAS mutational status in non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma in Korea.
    Thyroid 2018 Feb 14. Epub 2018 Feb 14.
    Asan Medical Center, University of Ulsan College of Medicine, Pathology, Seoul, Korea (the Republic of) ;
    Background: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor previously known as non-invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). The absence of BRAFV600E mutations has been considered characteristic of NIFTPs. However, a recent study from Korea found that 28. Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Endocr Relat Cancer 2018 Feb 9. Epub 2018 Feb 9.
    M Sobrinho-Simões, Patologia, Centro Hospitalar de Sao Joao EPE, Porto, Portugal
    The 2017 edition of the WHO book on Classification of Tumours of Endocrine Organs includes a new section entitled "Other encapsulated follicular-patterned thyroid tumours", in which the newly created NIFTP (Non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is identified and detailed described. Despite deleting the word "carcinoma" from its name, NIFTP is not a benign tumor either, and is best regarded as a neoplasm with "very low malignant potential". The main goal of the introduction of NIFTP category is to prevent overdiagnosis and overtreatment. Read More

    Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort.
    J Clin Endocrinol Metab 2018 Feb 8. Epub 2018 Feb 8.
    Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA.
    Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease.

    Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort.

    Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015. Read More

    Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma.
    Biomed Res Int 2017 25;2017:8701386. Epub 2017 Dec 25.
    Department of Morphofunctional Sciences I-Histology, Pathology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Background: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors.

    Aim: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors.

    Material And Methods: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. Read More

    Comparison of clinical characteristics of patients with follicular thyroid carcinoma and Hürthle cell carcinoma.
    Endocrinol Diabetes Nutr 2018 Feb 9. Epub 2018 Feb 9.
    Facultad de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Navarra, España.
    Introduction: Hürthle cell carcinoma (HCC) is an uncommon thyroid cancer historically considered to be a variant of follicular thyroid carcinoma (FTC). The aim of this study was to assess the differences between these groups in terms of clinical factors and prognoses.

    Patients And Methods: A total of 230 patients (153 with FTC and 77 with HCC) with a median follow-up of 13. Read More

    Preoperative Cytologic Diagnosis of Warthin-like Tumor Variant of Papillary Thyroid Carcinoma.
    J Pathol Transl Med 2018 Feb 12. Epub 2018 Feb 12.
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution. Read More

    The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the rate of malignancy for atypia of undetermined significance subcategories.
    Cancer Cytopathol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
    Background: The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine-needle aspiration (FNA) cytology.

    Methods: Consecutive thyroid FNAs interpreted as AUS over a period of 4 years were retrospectively analyzed. Read More

    Incidental thyroid carcinoma in patients with TIR1, TIR2 and TIR3 FNA.
    Ann Ital Chir 2018 Feb 9;7. Epub 2018 Feb 9.
    Aim: The aim of our study was to evaluate the presence of incidental differentiated thyroid carcinomas, at final histological examination, in patients undergoing thyroidectomy or lobectomy for presumed benign pathology or in those with cytological diagnosis of indeterminate nodules (TIR3).

    Material Of Study: 457 patients who underwent surgery for benign disease and 179 patients with indeterminate FNA were included in our study.

    Results: 77 out of 457 patients had the diagnosis of differentiated thyroid carcinoma. Read More

    The presence of papillary features in thyroid nodules diagnosed as atypia of undetermined significance or follicular lesion of undetermined significance increases cancer risk and should influence treatment.
    Am J Surg 2018 Jan 5. Epub 2018 Jan 5.
    Department of Surgery, St. Paul's Hospital & University of British Columbia, Vancouver, BC, Canada. Electronic address:
    Background: The objective of this study was to evaluate the influence of papillary features on risk of malignancy (ROM) within the Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance (AUS-FLUS) Bethesda System for Reporting Thyroid Cytopathology (BSRTC) diagnostic category.

    Methods: A Retrospective review of cases with an AUS-FLUS diagnosis that underwent a thyroidectomy was carried out, and cases were subcategorized based upon the presence of papillary features.

    Results: For the entire study population there were 93 (22%) of 427 FNAB specimens that had an AUS-FLUS diagnosis, and a 32% associated ROM. Read More

    Synchronous papillary thyroid cancer and non-Hodgkin lymphoma: Case report.
    Medicine (Baltimore) 2018 Feb;97(6):e9831
    General and Surgical Oncology Division, University of Perugia, Perugia, Italy.
    Rationale: Differentiated thyroid cancer is the most common endocrine malignancy with concomitant hematological malignancy in 7%.

    Patient Concerns: We present a case of a synchronous papillary thyroid cancer and a follicular variant of non-Hodgkin lymphoma and discuss the possible diagnostic and treatment dilemmas.

    Diagnosis: A 48-year-old female was reffered to our hospital with diagnosis "thyroid cancer". Read More

    Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens.
    Ann Diagn Pathol 2018 Feb 18;32:35-40. Epub 2017 Sep 18.
    Department of Pathology, Gachon University Gil Medical Center, Incheon, Republic of Korea. Electronic address:
    Background: Core needle biopsy (CNB) has been used as an alternative or a complementary method for diagnosis of thyroid nodules. However, morphological analysis of the nuclear features of papillary thyroid carcinoma (PTC) cells obtained via CNB remains unclear. Hence, we examined the differences between the PTC nuclear features in CNB and thyroidectomy specimens. Read More

    HMGA2 Gene Expression in Fine-needle Aspiration Samples of Thyroid Nodules as a Marker for Preoperative Diagnosis of Thyroid Cancer.
    Appl Immunohistochem Mol Morphol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
    There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction. Read More

    Galectin-3 and HBME-1 Expression on Agarose Cell Blocks from Fine-needle aspirates of Follicular Cell-derived Thyroid Tumors.
    J Cytol 2018 Jan-Mar;35(1):27-32
    Department of Pathology, Faculty of Medicine, Cairo University, Egypt.
    Aim: To test the expression of galectin-3 (gal-3) and Hector Battifora mesothelial antigen-1 (HBME-1) on agarose cell blocks (CBs) of fine-needle aspirates aiming to determine their diagnostic value in thyroid follicle cell-derived tumors.

    Materials And Methods: Forty patients with thyroid nodule were enrolled. Fine-needle aspiration biopsy was done and processed to produce smears and CBs. Read More

    Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP).
    Endocr Pathol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
    Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor characterized by frequent RAS mutations and an absence of the BRAF V600E mutation commonly seen in classical papillary thyroid carcinoma (cPTC). The ability to differentiate potential NIFTP/follicular variant of papillary thyroid carcinoma (FVPTC) from cPTC at the time of fine-needle aspiration (FNA) can facilitate conservative management of NIFTP. The aim of the current study was to investigate how molecular testing may add to cytologic assessment in the pre-operative differentiation of potential NIFTP/FVPTC and cPTC. Read More

    Histologic Outcome of Indeterminate Thyroid Nodules Classified at Low or High Risk.
    Endocr Pathol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Via Ospedale 12, 6500, Bellinzona, Switzerland.
    The revised Italian consensus for the classification and reporting of thyroid cytology (ICCRTC) was published in 2014. Very recently, a high reliability of ICCRTC in classifying low and high risk indeterminate nodules (Tir 3A and Tir 3B, respectively) was demonstrated. This finding prompted us to review our case series of thyroid indeterminate lesions to verify these data. Read More

    Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: Should it also be reclassified in children?
    Pediatr Blood Cancer 2018 Jan 30. Epub 2018 Jan 30.
    Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
    Background: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (noniEFVPTC) has low risk of adverse outcome in adults, warranting reclassification as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). In children, thyroid nodules have higher risk of malignancy and it is unknown if encapsulated FVPTC (EFVPTC) and infiltrative FVPTC (IFVPTC) tumors have different behavior. We analyzed the clinicopathologic features of follicular variant of papillary thyroid carcinoma (FVPTC) subtypes in our pediatric population to determine if noniEFVPTC has an indolent course as reported in adults. Read More

    Discriminatory miRNAs for the management of papillary thyroid carcinoma and noninvasive follicular thyroid neoplasms with papillary-like nuclear features.
    Thyroid 2018 Jan 29. Epub 2018 Jan 29.
    Kuwait University Faculty of Medicine, 62797, Safat, Al Asimah, Kuwait ;
    Background: Papillary thyroid carcinoma (PTC) variants have several overlapping clinical and pathological features. The World Health Organization (WHO) published recently a new classification of thyroid tumors containing significant revisions. the encapsulated papillary thyroid carcinoma (EPTC) has been recognized as a distinctive variant of PTC. Read More

    The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells.
    Oncotarget 2017 Dec 12;8(69):114136-114155. Epub 2017 Dec 12.
    Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland.
    The prospero homeobox 1 (Prox1) transcription factor is a key player during embryogenesis and lymphangiogenesis. Altered Prox1 expression has been found in a variety of human cancers, including papillary thyroid carcinoma (PTC). Interestingly, Prox1 may exert tumor suppressive or tumor promoting effect, depending on the tissue context. Read More

    Application of Strict Criteria for Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and Encapsulated Follicular Variant Papillary Thyroid Carcinoma: a Retrospective Study of 50 Tumors Previously Diagnosed as Follicular Variant PTC.
    Endocr Pathol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Pathology, Emory University Hospital Midtown, 550 Peachtree St. NE, Davis-Fischer Building Suite 1314-A, Atlanta, GA, 30308, USA.
    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a designation for a subset of follicular variant papillary thyroid carcinoma (FVPTC). Encapsulated FVPTC has been shown to be a fairly indolent tumor, and NIFTP are expected to represent the most indolent subset of these tumors. Many of the exclusion criteria for NIFTP related to architecture and a lack of psammoma bodies are designed to preclude the inclusion of more aggressive non-FVPTC tumors in this indolent group and also exclude the diagnosis of FVPTC. Read More

    Demographic and Clinical Features of Thyroid Carcinomas in Republic of Macedonia (1999-2010).
    Open Access Maced J Med Sci 2017 Dec 17;5(7):1005-1010. Epub 2017 Oct 17.
    Institute of Pathology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
    Background: Thyroid carcinomas (TC) are the most common endocrine malignancies. In some parts of the world, the incidence of TCs has increased over the past few decades, especially in females according to some studies.

    Aim: We have set as the objective for our study to analyse the demographic, ultrasound features, thyroid hormonal status and frequency of thyroid carcinomas in the Republic of Macedonia according to histopathological type. Read More

    Integrated microRNA-mRNA analyses of distinct expression profiles in follicular thyroid tumors.
    Oncol Lett 2017 Dec 6;14(6):7153-7160. Epub 2017 Oct 6.
    Department of Thyroid and Neck Tumors, Tianjin Medical University Cancer Institute and Hospital, Oncology Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin 300060, P.R. China.
    MicroRNAs (miRNAs/miRs) are small non-coding RNAs identified in plants, animals and certain viruses; they function in RNA silencing and post-transcriptional regulation of gene expression. miRNAs also serve an important role in the pathogenesis, diagnosis and treatment of tumors. However, few studies have investigated the role of miRNAs in thyroid tumors. Read More

    Clinical Characteristics of Subtypes of Follicular Variant Papillary Thyroid Carcinoma.
    Thyroid 2018 Feb 16. Epub 2018 Feb 16.
    1 Department of Internal Medicine, Seoul National University College of Medicine , Seoul, Republic of Korea.
    Background: Among follicular variant papillary thyroid carcinomas (FVPTCs), the noninvasive encapsulated subtype has an excellent prognosis. For this reason, reclassification of noninvasive encapsulated FVPTC (EFVPTC) as a new entity called "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) has been proposed, but controversy remains. To characterize noninvasive EFVPTC in an Asian population, the clinicopathologic features of each FVPTC subtype were compared in a Korean population. Read More

    CT imaging of primary pancreatic lymphoma: experience from three referral centres for pancreatic diseases.
    Insights Imaging 2018 Feb 15;9(1):17-24. Epub 2018 Jan 15.
    Department of Radiology, Policlinico G. B. Rossi, University of Verona, Verona, Italy.
    Purpose: To describe CT characteristics of primary pancreatic lymphoma (PPL), a rare disease with features in common with adenocarcinoma.

    Materials And Methods: Fourteen patients were enrolled. CT: unenhanced scan, contrast-enhanced pancreatic and venous phases. Read More

    Autonomously hyperfunctioning cystic nodule harbouring thyroid carcinoma - Case report and literature review.
    Int J Surg Case Rep 2018 8;42:287-289. Epub 2018 Jan 8.
    Department of Surgery, Hospital Pedro Hispano, Rua Dr. Eduardo Torres, 4464-513 Senhora da Hora, Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address:
    Introduction: Hyperthyroidism is rarely associated with malignancy, but it cannot rule out thyroid cancer. Although there is published data describing this coexistence, thyroid carcinomas inside autonomously functioning nodules are uncommon.

    Presentation Of Case: A 49-year-old woman presented with a cervical mass, unexplained weight loss and anxiousness, sweating and insomnia. Read More

    Effect of hypoparathyroid on bone mineral density of lumber spine in postmenopausal women with differentiated thyroid cancinoma.
    Hell J Nucl Med 2017 Sep-Dec;20 Suppl:7-13
    Nuclear Medicine, Shaanxi Provincial People's Hospital, China.
    Objective: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC).

    Subject And Methods: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Read More

    CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension.
    BMC Cancer 2018 01 10;18(1):68. Epub 2018 Jan 10.
    i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.
    Background: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis.

    Methods: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of capsular invasion: two minimally invasive (mFTC) and two widely invasive FTC (wFTC). Read More

    Histogram analysis of greyscale sonograms to differentiate between the subtypes of follicular variant of papillary thyroid cancer.
    Clin Radiol 2018 Jan 6. Epub 2018 Jan 6.
    Department of Applied Statistics, Chung-Ang University, 221, Heukseok-dong, Dongjak-gu, Seoul 156-756, South Korea.
    Aim: To evaluate the diagnostic value of histogram analysis using ultrasound (US) to differentiate between the subtypes of follicular variant of papillary thyroid carcinoma (FVPTC).

    Materials And Methods: The present study included 151 patients with surgically confirmed FVPTC diagnosed between January 2014 and May 2016. Their preoperative US features were reviewed retrospectively. Read More

    Ectopic papillary thyroid carcinoma within a thyroglossal duct cyst: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8921
    Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg.
    Rationale: Ectopic thyroid carcinoma within a thyroglossal duct cyst (TGDCCa) is an extremely rare entity. Thus, there is no unified appropriate therapeutic strategy, and individual approaches are controversial.

    Patients Concerns: We report the case of a 21-year old woman who underwent Sistrunk procedure for a thyroglossal duct cyst (TGDC). Read More

    Cyclooxygenase-2 (COX-2) gene polymorphism in patients with differentiated thyroid carcinomas in the Turkish population
    Turk J Med Sci 2017 Dec 19;47(6):1848-1853. Epub 2017 Dec 19.
    Background/aim: The most common thyroid malignancies are papillary and follicular thyroid carcinomas. They account for approximately 85%-90% of all thyroid cancers. Recent studies have reported the relevance of cyclooxygenase-2 (COX-2) gene polymorphism in human carcinogenesis. Read More

    Modified transoral endoscopic thyroid surgery for treatment of thyroid cancer: operative steps and video.
    Gland Surg 2017 Dec;6(6):742-744
    Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha 410008, China.
    In this video we describe a kind of modified transoral endoscopic thyroid surgery involving meticulous dissection of mental nerve. Inclusion criteria are: the diameter of benign tumors such as thyroid cyst, nodular goiter were limited less than 50 mm; the malignant thyroid tumors including follicular and papillary microcarcinoma were defined as a papillary carcinoma <2 cm in diameter and endoscopic surgery required for the patient. A 6 cm arc-shaped incision was designed at oral vestibule. Read More

    A six-gene panel to label follicular adenoma, low- and high-risk follicular thyroid carcinoma.
    Endocr Connect 2018 Jan;7(1):124-132
    Department of SurgicalMedical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy
    The distinction between follicular thyroid carcinomas (FTCs) and follicular-patterned benign lesions is almost impossible on fine-needle aspiration cytology. Furthermore, minimally invasive FTCs (MI-FTCs) with less than 4 vascular invasion foci generally have an excellent prognosis, but there are exceptions and, so far, no molecular marker appears able to identify them reliably. We aimed to distinguish benign lesions from low- and high-risk FTCs by a small-scale combination of genes. Read More

    Gene Fusions in Thyroid Cancer.
    Thyroid 2018 Feb;28(2):158-167
    1 Research Centre for Medical Genetics , Moscow, Russian Federation.
    Background: Gene fusions are known in many cancers as driver or passenger mutations. They play an important role in both the etiology and pathogenesis of cancer and are considered as potential diagnostic and prognostic markers and possible therapeutic targets. The spectrum and prevalence of gene fusions in thyroid cancer ranges from single cases up to 80%, depending on the specific type of cancer. Read More

    Thyroid disease in children and adolescents with PTEN hamartoma tumor syndrome (PHTS).
    Eur J Pediatr 2018 Mar 22;177(3):429-435. Epub 2017 Dec 22.
    Pediatric Endocrinology and Diabetology Division, Children's Hospital, University of Bonn, Adenauerallee 119, 53113, Bonn, Germany.
    Patients with PTEN hamartoma tumor syndrome (PHTS) are at increased risk of developing benign and malignant tumors, including thyroid carcinoma. Benign thyroid lesions and single cases of thyroid carcinoma have been reported in children with PHTS. We conducted a retrospective, single-centered study including children and adolescents with a molecularly proven diagnosis of PTEN. Read More

    Impact of the Reclassification of "Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma" to "Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features" on the Bethesda System for Reporting Thyroid Cytopathology: A Large Academic Institution's Experience.
    Am J Clin Pathol 2017 Dec;149(1):50-54
    Department of Pathology, New York University School of Medicine, New York, NY.
    Objectives: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (NEFVPTC) was recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Excluding "carcinoma" from the new terminology shifted NIFTP out of the malignant category and altered Bethesda System for Reporting Thyroid Cytopathology (BSRTC) rates of malignancy (ROMs) on thyroid fine-needle aspiration (FNA). Because of potential effects on management guidelines, we examined our ROM data. Read More

    Artificial neural network model to distinguish follicular adenoma from follicular carcinoma on fine needle aspiration of thyroid.
    Diagn Cytopathol 2018 Mar 20;46(3):244-249. Epub 2017 Dec 20.
    Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Background: To distinguish follicular adenoma (FA) and follicular carcinoma (FC) of thyroid in fine needle aspiration cytology (FNAC) is a challenging problem.

    Aims And Objectives: In this article, we attempted to build an artificial neural network (ANN) model from the cytological and morphometric features of the FNAC smears of thyroid to distinguish FA from FC.

    Material And Methods: The cytological features and morphometric analysis were done on the FNAC smears of histology proven cases of FA (26) and FC (31). Read More

    Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review.
    J Endocr Soc 2017 May 23;1(5):396-400. Epub 2017 Mar 23.
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215.
    Context: The presence of differentiated thyroid cancer in mature cystic teratomas in the ovaries is rare, and usually incidentally found on surgical pathology specimens. We present a case of simultaneous intrathyroidal thyroid cancer and thyroid cancer within a struma ovarii, presenting specific diagnostic challenges.

    Case Description: A 55-year-old woman had an intrathyroidal, encapsulated 1. Read More

    Propensity score matching analysis of the prognosis for the rare insular subtype of thyroid cancer based on SEER database.
    Oncotarget 2017 Nov 11;8(60):101623-101633. Epub 2017 Oct 11.
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
    Insular thyroid carcinoma (ITC) is an uncommon thyroid malignancy with an unclear prognosis. The aim of this study was to determine the prognoses of patients with ITC. We investigated a large cohort of patients with differentiated thyroid cancer from the Surveillance, Epidemiology, and End Results (SEER) database who were registered between 2004 and 2013, and compared the prognosis of patients with ITC to those with classic papillary thyroid cancer (CPTC) and follicular thyroid cancer (FTC). Read More

    Propensity score matching analysis of the prognosis for the rare oxyphilic subtype of thyroid cancer (Hurthle cell carcinoma).
    Oncotarget 2017 Nov 8;8(60):101362-101371. Epub 2017 Sep 8.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
    There is controversy regarding the prognosis of patients with oxyphilic thyroid cancer (OXTC). The present study compared the prognoses of OXTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC), in order to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Read More

    Ovarian strumal carcinoid - case report.
    Rom J Morphol Embryol 2017 ;58(3):1035-1040
    Department of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;
    Strumal carcinoid represents a rare form of ovarian teratoma, consisting of both thyroid tissue and carcinoid structures. The carcinoid component is a well-differentiated neuroendocrine tumor with excellent prognosis. Strumal carcinoid tumors are commonly found in peri-menopausal women who are not usually interested in preserving their fertility and who are thus open to radical surgical treatment. Read More

    1 OF 179