9,399 results match your criteria Thyroid Follicular Carcinoma


Differentiated Thyroid Cancer in Children: A UK Multicentre Review and Review of the Literature.

Clin Oncol (R Coll Radiol) 2019 Mar 14. Epub 2019 Mar 14.

Royal Marsden NHS Foundation Trust Thyroid Unit, London, UK.

Aims: To obtain an overview of the management and outcomes of children aged 18 years or younger diagnosed with differentiated thyroid carcinoma of follicular cell origin across the UK, by collecting and analysing data from the limited number of centres treating these patients. This multicentre data might provide a more realistic perspective than single-institution series.

Materials And Methods: Six centres submitted data extracted from historical records on patients aged 18 years or younger, diagnosed between 1964 and 2017. Read More

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http://dx.doi.org/10.1016/j.clon.2019.02.005DOI Listing

Exosomes increased angiogenesis in papillary thyroid cancer microenvironment.

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

Z Mo, Department of Endocrinology, Third Xiang-Ya Hospital, Central South University, Changsha, China.

Tumour-derived exosomes under hypoxic conditions contain informative microRNAs involved in the interaction of cancer and para-carcinoma cells, thus contributing to tissue remodelling of the tumour microenvironment (TME). Exosomes isolated from hypoxic papillary thyroid cancer cells, BCPAP cells and KTC-1 cells, enhanced the angiogenesis of human umbilical vein endothelial cells (HUVECs) compared with exosomes isolated from normal thyroid follicular cell line (Nthy-ori-3-1), normoxic BCPAP cells or KTC-1 cells both in vitro and vivo. miR-21-5p was significantly upregulated in exosomes from papillary thyroid cancer BCPAP cells under hypoxic conditions, while the exosomes isolated from hypoxic BCPAP cells with knock-down of miR-21-5p attenuated the promoting effect of angiogenesis. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-19-
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http://dx.doi.org/10.1530/ERC-19-0008DOI Listing
March 2019
1 Read

Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update.

Endocrine 2019 Mar 13. Epub 2019 Mar 13.

Division of Cytopathology, Department of Pathology, The Johns-Hopkins Hospital, Baltimore, USA.

Background: The nomenclature "Non-invasive Follicular Neoplasm with Papillary-like Nuclear Features (NIFTP)" was introduced in 2016. While NIFTP differs from classic papillary thyroid carcinoma (PTC) in imaging, cytomorphology, histology, molecular profile, treatment, follow up, outcome, and behavior, it largely overlaps with follicular variant of PTC at imaging and cytomorphology. Herein, we review the literature for better understanding NIFTP, and its impact on patient care. Read More

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http://dx.doi.org/10.1007/s12020-019-01887-zDOI Listing

Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features.

Endocr J 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, Kuma Hospital, Kobe 856-8562, Japan.

We studied cytological specimens of conventional papillary thyroid carcinoma (PTC), follicular variant papillary thyroid carcinoma (FVPTC), and noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) (formerly noninvasive FVPTC) to identify useful cytological parameters for their differentiation. Cytological findings of invasive FVPTC and NIFTP were very similar to each other but differed from those of conventional PTC. Intranuclear cytoplasmic inclusions, true papillary cell clusters, monolayered cell sheets, ropy colloids, multinucleate giant cells, psammoma bodies, and cystic background were the observed characteristic features of conventional PTC. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0525DOI Listing

RISK OF MALIGNANCY IN THYROID CYTOLOGY: THE IMPACT OF THE RECLASSIFICATION OF NONINVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP).

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Endocrinology, Diabetes and Metabolism Department, University and Hospital Center of Coimbra, Coimbra, Portugal.

Objectives: Non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NEFVPTC) was recently reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). We aimed to compare the risk of malignancy (ROM) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) on fine-needle aspiration cytology (FNAC), before and after the reclassification, in a large cohort of patients.

Methods: We analyzed 5. Read More

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http://dx.doi.org/10.4158/EP-2018-0423DOI Listing

BRAF mutation in cytologically indeterminate thyroid nodules: after reclassification of a variant thyroid carcinoma.

Onco Targets Ther 2019 21;12:1465-1473. Epub 2019 Feb 21.

Department of Otorhinolaryngology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand,

Purpose: Fine-needle aspiration biopsy (FNAB) is regarded by the Bethesda system as the gold-standard investigation for stratifying the risk of malignancy of a thyroid nodule. However, some limitations affect the adequacy of the obtained materials, resulting in 30% of the cytological results remaining in the indeterminate category. We aimed to investigate the diagnostic value of the BRAF mutation in cytologically indeterminate thyroid nodules after the reclassification of a variant thyroid carcinoma. Read More

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http://dx.doi.org/10.2147/OTT.S190001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391130PMC
February 2019

Transoral endoscopic thyroidectomy using vestibular approach: A single center experience.

J Postgrad Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Seth GS Medical College, Parel, Mumbai, Maharashtra, India.

Background: Thyroid Natural Orifice Transluminal Endoscopic Surgery (NOTES) or transoral endoscopic thyroidectomy using vestibular approach is a recent advance embraced by the surgical community because of its potential for a scar-free thyroidectomy. In this article, we present our initial experience with this technique.

Materials And Methods: We used a three-port technique through the oral vestibule, one 10 mm port for the laparoscope and two additional 5 mm ports for the endoscopic instruments required. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_117_18DOI Listing

AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients.

Endocr Connect 2019 Mar 1. Epub 2019 Mar 1.

A Beckers, Service d'Endocrinologie, CHU de Liège, Liege, Belgium.

Acromegaly is a rare disease due to chronic excess growth hormone (GH) and IGF-1. Aryl hydrocarbon receptor interacting protein (AIP) mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogs (SSA). The role of pasireotide, an SSA with affinity for multiple SSTs, in patients with AIP mutations has not been reported. Read More

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http://dx.doi.org/10.1530/EC-19-0004DOI Listing
March 2019
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Short Review: Genomic alterations in Hürthle cell carcinoma.

Thyroid 2019 Mar 8. Epub 2019 Mar 8.

University of Texas Southwestern Medical Center, Department of Internal Medicine, Division of Endocrinology, Dallas, Texas, United States ;

Hürthle cell tumors (HCT), including Hürthle cell adenomas (HCA) and Hürthle cell carcinomas (HCC) arise in the thyroid gland and are defined in part by an accumulation of mitochondria. These neoplasms were long considered a subtype of follicular neoplasm, although HCT is now generally considered a distinct entity. HCTs exhibit overlapping but distinct clinical features compared to follicular tumors, and several studies have demonstrated that HCTs harbor distinct genomic alterations compared to other forms of thyroid cancer. Read More

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https://www.liebertpub.com/doi/10.1089/thy.2019.0088
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http://dx.doi.org/10.1089/thy.2019.0088DOI Listing
March 2019
6 Reads

Influence of the reclassification of NIFTP as a uncertain tumor on risk of malignancy for the diagnostic categories according to the Bethesda System for Reporting Thyroid Cytopathology.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Klinika Endokrynologii, Świętokrzyskie Centrum Onkologii, Kielce, Poland.

Purpose: The noninvasive encapsulated, follicular variant of papillary thyroid carcinoma was reclassified as Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). The exclusion of NIFTP from the group of malignant tumors decreases the risk of malignancy (RoM) as defined by the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The aim of the present study was to evaluate the RoM for each category in TBSRTC with and without exclusion of NIFTP from the tally of malignancies. Read More

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http://dx.doi.org/10.5603/EP.a2019.0008DOI Listing

Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced, PD-L1-positive papillary or follicular thyroid cancer.

BMC Cancer 2019 Mar 4;19(1):196. Epub 2019 Mar 4.

Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.

Background: Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients with advanced differentiated thyroid cancer expressing programmed death ligand 1 (PD-L1).

Methods: Patients with advanced thyroid cancer were enrolled in the nonrandomized, phase Ib KEYNOTE-028 trial conducted to evaluate safety and antitumor activity of the anti-programmed death 1 (PD-1) antibody pembrolizumab in advanced solid tumors. Read More

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http://dx.doi.org/10.1186/s12885-019-5380-3DOI Listing
March 2019
1 Read

Interobserver and intraobserver variation in the morphological evaluation of noninvasive follicular thyroid neoplasm with papillary-like nuclear features in Asian practice.

Pathol Int 2019 Feb 27. Epub 2019 Feb 27.

Faculty of Medicine, Department of Pathology, Nara Hospital, Kindai University, Nara, Japan.

To evaluate the current diagnostic criteria in reporting nuclear features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), nine Asian pathologists with expertise in thyroid reviewed virtual slides of 30 noninvasive follicular patterned thyroid lesions according to the nuclear scoring system originally proposed by an international expert and a more detailed scoring system proposed by the Asian Working Group. The interobserver agreement for nuclear grading score was generally moderate (kappa value = 0.452). Read More

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http://dx.doi.org/10.1111/pin.12779DOI Listing
February 2019
1 Read
1.585 Impact Factor

The Impact of Zoledronic Acid and Radioactive Iodine Therapy on Morbi-Mortality of Patients with Bone Metastases of Thyroid Cancer Derived from Follicular Cells.

Eur Thyroid J 2019 Jan 3;8(1):46-55. Epub 2018 Oct 3.

Department of Medicine, Endocrinology Service, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil.

Objective: Bone metastases bring greater morbi-mortality to patients with differentiated thyroid carcinoma (DTC). Treatment was limited to radioactive iodine (RAI) and local approaches. Currently, bisphosphonates are included in the therapeutic arsenal. Read More

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http://dx.doi.org/10.1159/000493190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381918PMC
January 2019
1 Read

Evaluation of Diagnostic Utility of Immunohistochemistry Markers of TROP-2 and HBME-1 in the Diagnosis of Thyroid Carcinoma.

Eur Thyroid J 2019 Jan 22;8(1):1-6. Epub 2018 Nov 22.

Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: The diagnosis of thyroid tumors is based on histologic features, but the distinction between benign and malignant thyroid lesions is somehow difficult, especially in lesions with a follicular pattern. Thus, ancillary studies, such as immunohistochemistry (IHC), may be helpful. In this study, we aimed to evaluate the diagnostic value of 2 IHC markers, TROP-2 and HBME-1, in the diagnosis of thyroid cancers. Read More

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http://dx.doi.org/10.1159/000494430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381885PMC
January 2019
1 Read

Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy.

Oncol Res Treat 2019 23;42(3):136-142. Epub 2019 Feb 23.

Thyroid cancer is a rare malignancy and accounts for less than 1% of malignant neoplasms in humans; however, it is the most common cancer of the endocrine system and responsible for most deaths from endocrine cancer. Long non-coding (Lnc)RNAs are defined as non-coding transcripts that are more than 200 nucleotides in length. Their expression deregulation plays an important role in the progress of cancer. Read More

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http://dx.doi.org/10.1159/000495151DOI Listing
February 2019
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Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma: A case report.

Diagn Cytopathol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. Read More

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http://dx.doi.org/10.1002/dc.24159DOI Listing
February 2019
2 Reads

Relationship between genetic alterations and clinicopathological characteristics of papillary thyroid carcinoma.

Med Mol Morphol 2019 Feb 20. Epub 2019 Feb 20.

Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.

Papillary thyroid carcinoma (PTC) is characterized by proliferation of follicular cells with distinctive nuclear features such as ground glass appearance, nuclear groove and pseudoinclusion. From the proliferation pattern, PTC is divided into several histological subtypes; conventional histology is classified as papillary type, and there are also follicular and solid variants. PTC is heterogeneous in genetic alterations. Read More

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http://dx.doi.org/10.1007/s00795-019-00217-6DOI Listing
February 2019
1 Read

Core-needle biopsy in thyroid nodules: performance, accuracy, and complications.

Eur Radiol 2019 Feb 19. Epub 2019 Feb 19.

University of the Basque Country (UPV/EHU), Leioa, Spain.

Objective: To evaluate the performance of core-needle biopsy (CNB) in thyroid using a cohort of patients in which it was used as first choice.

Methods: Our institutional review board approved this retrospective study. We reviewed all CNB performed in our center over a period of 11 years. Read More

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http://link.springer.com/10.1007/s00330-019-06038-6
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http://dx.doi.org/10.1007/s00330-019-06038-6DOI Listing
February 2019
7 Reads

Expression of in Circulating Tumor Cells May Distinguish Follicular Thyroid Carcinomas from Adenomas: Implications for Blood-Based Preoperative Diagnosis.

J Clin Med 2019 Feb 18;8(2). Epub 2019 Feb 18.

Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea.

Preoperative diagnosis of thyroid nodules reduces unnecessary surgery. Circulating tumor cells (CTCs) may contain information of primary tumor(s). We asked whether the peripheral blood expression of genes specific for circulating tumor cells (CTCs) differentiates benign thyroid nodules from malignant nodules. Read More

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http://www.mdpi.com/2077-0383/8/2/257
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http://dx.doi.org/10.3390/jcm8020257DOI Listing
February 2019
3 Reads

Detection of the sentinel node using a magnetic tracer in thyroid cancer. A technical pilot study.

Cir Esp 2019 Mar 14;97(3):169-174. Epub 2019 Feb 14.

Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Servicio Murciano de Salud, Murcia, España; Instituto Murciano de Investigación Bio-Sanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, España.

Introduction: There is no standard procedure for the detection of the sentinel node (SN) in thyroid disease. However, the recent detection of the SN using a paramagnetic tracer is proving to be useful in breast cancer and melanoma. The objective was to assess the utility of super paramagnetic iron oxide tracer for the intraoperative detection of the SN in patients with papillary thyroid cancer without nodal involvement in the preoperative study. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.12.003DOI Listing
March 2019
5 Reads

Presurgical Screening of Fine Needle Aspirates from Thyroid Nodules for Mutations: A Prospective Single Center Experience.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):785-792

Department of Endocrine Surgery, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India.

Objective: Analysis of BRAF V600E mutation in thyroid fine needle aspirates (FNA) is an important adjunct to cytology, particularly among FNA placed in the "indeterminate category." However, such a prospective evaluation of FNA obtained from patients with thyroid nodules has been lacking from India.

Material And Methods: FNA from 277 patients were prospectively evaluated for BRAF mutations by Sanger's sequencing. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_126_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330867PMC
February 2019
1 Read

Unusual Sites of Metastatic and Benign I 131 Uptake in Patients with Differentiated Thyroid Carcinoma.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):740-750

Department of Nuclear Medicine and Molecular Imaging, Amrita Institute of Medical Sciences, Amrita Vishwavidyapeetham, Cochin, Kerala, India.

Introduction: Differentiated thyroid carcinoma (DTC) is the most common pathological type of thyroid carcinoma, which includes papillary and follicular subtypes. DTC is usually indolent, characterized by good prognosis, and long-term survival. Total thyroidectomy is the mainstay of treatment in DTC which is followed by diagnostic whole body 131I (WBI) scan. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_70_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330860PMC
February 2019
3 Reads

Association between DNA methylation profile and malignancy in follicular-patterned thyroid neoplasms.

Endocr Relat Cancer 2019 Feb 1. Epub 2019 Feb 1.

M Santoro, Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Napoli, Italy.

Molecular differentiation between benign (follicular thyroid adenoma, FTA) and malignant (follicular thyroid carcinoma, FTC) thyroid neoplasms is challenging. Here, we explored the genome-wide DNA methylation profile of FTA (n.10) and FTC (n. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-18-
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http://dx.doi.org/10.1530/ERC-18-0308DOI Listing
February 2019
11 Reads

Clinicopathological Significance of Overall Frequency of Allelic Loss (OFAL) in Lesions Derived from Thyroid Follicular Cell.

Mol Diagn Ther 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251 St, 92-213, Lodz, Poland.

Background: Loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumor etiopathogenesis occurring in several chromosomal critical areas, including 3p12-25.3, 7q21-31, 10q22-24, and 15q11-13, with loci of tumor suppressor genes.

Objective: We evaluated the usefulness of LOH/MSI as a diagnostic/prognostic biomarker in lesions derived from thyroid follicular cells: follicular thyroid carcinoma (FTC); follicular adenoma (FA), papillary thyroid carcinoma (PTC), and nodular goiter (NG). Read More

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http://dx.doi.org/10.1007/s40291-019-00387-0DOI Listing
February 2019
2 Reads

Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers.

Thyroid 2019 Feb 12. Epub 2019 Feb 12.

The Ohio State University, Department of Cancer Biology and Genetics, Columbus, Ohio, United States ;

Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach and colorectal cancers as well as more rarely in other solid tumor types. The prevalence of MSI in thyroid cancer has not been explored in-depth, although recent studies utilizing data from large cancer sequencing efforts such as The Cancer Genome Atlas indicate MSI is absent or at least very rare in the most common and most well-studied histologic subtype, papillary carcinoma. In this study, we aim to determine the prevalence of MSI in thyroid cancer by using a large series comprising all major histological subtypes. Read More

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http://dx.doi.org/10.1089/thy.2018.0655DOI Listing
February 2019
1 Read
4.493 Impact Factor

Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects.

Thyroid 2019 Mar;29(3):311-321

1 Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Poorly differentiated thyroid cancer (PDTC) is a rare but clinically highly significant entity because it accounts for most fatalities from non-anaplastic follicular cell-derived thyroid cancer. Due to the relative rarity of the disease and heterogeneous diagnostic criteria, studies on PDTC have been limited. In light of the evolution of ultra-deep next-generation sequencing technologies and through correlation of clinicopathologic and genomic characteristics of PDTC, an improved understanding of the biology of PDTC has been facilitated. Read More

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http://dx.doi.org/10.1089/thy.2018.0509DOI Listing
March 2019
2 Reads

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
6 Reads

[Ultrasound of Thyroid Nodules - Ultrasound Characteristics and Risk of Carcinoma].

Authors:
Daniela Schmidt

Laryngorhinootologie 2019 Feb 8;98(2):79-84. Epub 2019 Feb 8.

Nuklearmedizinische Klinik, Universitätsklinikum Erlangen, Erlangen.

Thyroid ultrasound is used as a first-line diagnostic procedure to evaluate thyroid nodules. Several ultrasound characteristics have been associated with an increased risk of malignancy. Based on these criteria, classification systems are being developed to categorize thyroid nodules and stratify their malignant risk to decide about further evaluation. Read More

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http://dx.doi.org/10.1055/a-0790-0849DOI Listing
February 2019
1 Read

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
March 2018
8 Reads

Angiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study.

Mod Pathol 2019 Feb 5. Epub 2019 Feb 5.

Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy.

Angiosarcoma and anaplastic carcinoma are the most lethal neoplasms of the thyroid worldwide and share some similarities, which have led to a longstanding controversy on their etiopathological relationship. Thyroid angiosarcomas are characterized by vessel formation and an immunophenotype common to endothelial cells, while anaplastic carcinomas are partially or wholly composed of mesenchymal-like cells that have lost the morphologic and functional features of normal thyroid follicular cells. To investigate whether angiosarcomas represent the endothelial extreme of the differentiation spectrum of carcinomas or they are bona fide vascular neoplasms, we studied the clinico-morphologic and genetic characteristics of a series of 10 angiosarcomas and 22 anaplastic carcinomas. Read More

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http://www.nature.com/articles/s41379-018-0199-z
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http://dx.doi.org/10.1038/s41379-018-0199-zDOI Listing
February 2019
5 Reads

MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8‑AS1:28.

Oncol Rep 2019 Feb 1. Epub 2019 Feb 1.

Department of Immunology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Read More

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http://dx.doi.org/10.3892/or.2019.6996DOI Listing
February 2019
1 Read
2.191 Impact Factor

The Current Histologic Classification of Thyroid Cancer.

Authors:
Sylvia L Asa

Endocrinol Metab Clin North Am 2019 03;48(1):1-22

Department of Laboratory Medicine and Pathobiology, University of Toronto, Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

Thyroid cancers of follicular cell derivation provide excellent phenotype-genotype correlations. Current morphologic classifications are complex and require simplification. Benign adenomas have follicular or papillary architecture and bland cytology. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.10.001DOI Listing
March 2019
1 Read

Expression of HBME-1 and CD56 in follicular variant of papillary carcinoma in children: An immunohistochemical study and their diagnostic utility.

Pathol Res Pract 2019 Jan 28. Epub 2019 Jan 28.

Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, United States. Electronic address:

Papillary thyroid carcinoma (PTC) is the most common differentiated thyroid cancer in children; and the follicular variant is the second most common variant after the classic subtype. The histological appearance of follicular variant of papillary thyroid cancer (FVPTC), can be mimicked by benign follicular nodules. Pediatric pathologists encountering such lesions with FVPTC-like appearance may err on diagnosing the benign lesions as malignant. Read More

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http://dx.doi.org/10.1016/j.prp.2019.01.031DOI Listing
January 2019
1 Read

Immunohistochemical and morphometrical evaluation of well-differentiated thyroid tumor of uncertain malignant potential.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):17-23

Department of Pathology, Tanta University, Egypt.

Context: Well-differentiated tumor of uncertain malignant potential (WDT-UMP) were encapsulated follicular pattern tumors with diffuse equivocal or focal unequivocal papillary thyroid carcinoma (PTC) type nuclear changes without definite invasion. These tumors are suggested to be borderline in its nature. Immunohistochemistry by CD56, P63, and CK19 are common markers used in differentiation between benign and malignant thyroid tumor. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_199_18DOI Listing
February 2019
1 Read

[Value of the detection of (V600E) gene mutation and protein expression in auxiliary cytological diagnosis of papillary thyroid carcinoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):18-22

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To evaluate the utility of the (V600E) mutation detection in different cytoloy categories and to determine if the VE1 antibody can serve as a screening tool for the detection of (V)600E mutation in thyroid fine needle aspiration (FNA) specimens. A total of 273 FNA residual specimens were collected. (V600E) testing was performed on these liquid-based specimens. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.005DOI Listing
January 2019
1 Read

Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.

Endocrine 2019 Jan 30. Epub 2019 Jan 30.

Department of Biomedical, Metabolic and Neural Sciences, Unit of Endocrinology, University of Modena and Reggio Emilia, Modena, Italy.

Purpose: Dysregulation of microRNA expression has been involved in the development and progression of follicular thyroid carcinoma (FTC). The aim of this work was to study the expression of miRNA146a in FTC and the association with clinicopathological features of the disease.

Methods: Thirty-eight patients affected by FTC were included in the study. Read More

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http://link.springer.com/10.1007/s12020-019-01845-9
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http://dx.doi.org/10.1007/s12020-019-01845-9DOI Listing
January 2019
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The Expression of FOXE-1 and STIP-1 in Papillary Thyroid Carcinoma and Their Relationship with Patient Prognosis.

Iran J Pathol 2018 17;13(2):256-271. Epub 2018 Jul 17.

Dept. of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background & Objective: Most patients with papillary carcinoma of the thyroid gland (PTC) havefavorable outcome,but sinceit has severe capability to invade the nearby tissues, there isa great risk of regional and distal lymph-nodes (LNs) metastases related to poor prognostic parameters, early recurrences, and distant metastasis that lead to bad patient outcome. Discovering other prognostic biomarkers for this cancer helps to detect early recurrences, invasion, expecting patient outcome, and possible use as therapeutic-targets for it. The , with the alternative name of , is one of thetranscription factors familiesthat is huge and containsa special fork-head-domain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339506PMC
July 2018
5 Reads

High Preponderance of BRAF V600E Mutation in Papillary Thyroid Carcinoma Among Filipinos: A Clinicopathologic Study.

J Glob Oncol 2019 Jan;5:1-6

Gerard Anthony M. Espiritu, Joemarie T. Malana, and Daphne C. Ang, Makati Medical Center, Makati; and Arlie Jean Grace V. Dumasis and Daphne C. Ang, St Luke's Medical Center, Taguig, Philippines.

Purpose: BRAF mutation in papillary thyroid carcinoma (PTC) is associated with an aggressive phenotype, with varying incidence. We evaluated the prevalence of BRAF mutations in PTC among Filipino patients and their correlation with clinicopathologic characteristics.

Patients And Methods: Clinicopathologic data were retrieved from 64 sequential patients who underwent thyroidectomy from June 2016 to December 2016. Read More

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http://dx.doi.org/10.1200/JGO.18.00085DOI Listing
January 2019
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[Resected Cases of Thyroid Tumor Diagnosed Class Ⅲ by Fine Needle Aspiration Cytology].

Gan To Kagaku Ryoho 2018 Dec;45(13):2114-2116

Dept. of Surgery, Tokyo Metropolitan Otsuka Hospital.

We describe 14 resected cases of thyroid tumor diagnosed as Class Ⅲ by fine needle aspiration cytology(FNA). Of these, 13 cases were diagnosed as: malignant tumor(1 case), suspicion of malignant tumor(5 cases), or were hard to distinguish from benign or malignant(7 cases). The operative methods used were total or near total thyroidectomy plus D1 or D2a in 4 cases; hemithyroidectomy plus D1 in 3 cases; subtotal thyroidectomy in 3 cases; and lobectomy of the thyroid in 4 cases. Read More

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December 2018
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Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features.

Endocrine 2019 Jan 28. Epub 2019 Jan 28.

Department of Surgery, Memorial Sloan Kettering Cancer center, New York, NY, USA.

Purpose: In 2016, non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NI-EFVPTC) was renamed as noninvasive thyroid follicular neoplasm with papillary-like nuclear features (NIFTP). However, as the study cohort did not mention tumors with oncocytic features, such lesions are still labeled by some as FVPTC. It is therefore crucial to evaluate the outcome and molecular profile of oncocytic NI-EFVPTC. Read More

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http://dx.doi.org/10.1007/s12020-019-01848-6DOI Listing
January 2019
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Detection of BRAF V600E mutation in fine-needle aspiration fluid of papillary thyroid carcinoma by droplet digital PCR.

Clin Chim Acta 2019 Apr 22;491:91-96. Epub 2019 Jan 22.

Central Laboratory, Huashan Hospital, Fudan University, Shanghai, China; Dept. of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objectives: Papillary thyroid carcinoma (PTC) accounts for 85% of thyroid carcinoma, which is the most common endocrine tumor. For the diagnosis of PTC, ultrasound-guided fine needle aspiration (FNA) with pathological evaluation is the standard test and BRAF V600E mutation is the most common molecular marker associated with the occurrence, progression and poor clinicopathological characteristics of PTC. However, because of the small amount of the tumor cells obtained by FNA for pathological evaluation or BRAF V600E mutation detection, more sensitive and accurate methods are required. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193003
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http://dx.doi.org/10.1016/j.cca.2019.01.017DOI Listing
April 2019
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Poorly differentiated thyroid carcinoma and poorly differentiated area in differentiated thyroid carcinoma: is there any difference?

Langenbecks Arch Surg 2019 Feb 23;404(1):45-53. Epub 2019 Jan 23.

Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014, India.

Purpose: Poorly differentiated thyroid carcinoma (PDTC) patients have worse outcomes than patients with differentiated thyroid carcinoma (DTC), but the implication of poorly differentiated areas (PDAs) noted in DTC is not very well understood. The aim of the present study was to compare the clinicopathologic profiles and outcomes of PDTC and DTC with PDA.

Methods: A total of 142 patients, managed at out center between September 1989 and June 2016, were enrolled in this retrospective study. Read More

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http://dx.doi.org/10.1007/s00423-019-01753-6DOI Listing
February 2019
2 Reads
2.160 Impact Factor

Targetable gene fusions identified in radioactive iodine refractory advanced thyroid carcinoma.

Eur J Endocrinol 2019 Apr;180(4):235-241

Department of Pathology, Division of Endocrinology, Leiden University Medical Centre, Leiden, the Netherlands.

Objective Gene alterations leading to activation of the MAPK pathway are of interest for targeted therapy in patients with advanced radioactive iodine refractory (RAI-R) thyroid carcinoma. Due to technical reasons gene fusion analysis in RNA isolated from formalin-fixed tumor tissues has till now been limited. The objective of the present study was to identify targetable gene rearrangements in RNA isolated from formalin-fixed RAI-R thyroid carcinomas. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0653DOI Listing
April 2019
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Modified Transverse-Vertical Gross Examination: a Better Method for the Detection of Definite Capsular Invasion in Encapsulated Follicular-Patterned Thyroid Neoplasms.

Endocr Pathol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

The diagnosis of encapsulated follicular-patterned thyroid carcinoma (EFPTC) is challenging, and the detection of capsular invasion and/or vascular invasion is essential in distinguishing benign lesions from malignant lesions. In this study, we present a modified transverse-vertical gross examination method with additional vertical cuts at the upper and lower ends of thyroid nodules. In addition, we compared the clinicopathological characteristics of patients with EFPTC between conventional and modified methods. Read More

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http://dx.doi.org/10.1007/s12022-019-9565-8DOI Listing
January 2019
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Ovarian Clear Cell Carcinoma in Cowden Syndrome.

J Natl Compr Canc Netw 2019 01;17(1):7-11

Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, Oncogénétique Clinique, CHU Montpellier, Université de Montpellier, Montpellier

Cowden syndrome (CS) is an autosomal dominant mendelian disease related to germline pathogenic variants affecting the -gene. CS is characterized by macrocephaly, mucocutaneous lesions, and an increased risk of breast and thyroid cancers. Rare ovarian cancer cases (mostly embryonic tumors) associated with have been described in the literature, but no current CS guidelines are available for ovarian cancer risk management. Read More

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http://dx.doi.org/10.6004/jnccn.2018.7065DOI Listing
January 2019
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Solid papillary thyroid carcinoma with Hashimoto's thyroiditis: description of a further case with challenging cytological features.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Solid papillary thyroid carcinoma (SV-PTC) is a rare variant which is mainly observed in young patients with a history of exposure to ionising radiations. Neoplasms belonging to such category generally carry RET-PTC (REarranged during Transfection- Papillary Thyroid Carcinoma) fusions and seem to have a slightly worse prognosis with respect to classical and follicular variants of papillary thyroid carcinoma (PTC), though consistent prognostic and survival data are scarce. SV-PTC should be differentiated from trabecular-insular poorly differentiated thyroid carcinomas, which occur in a different age group and carry a dismal prognosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226153DOI Listing
January 2019
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LONG-TERM OUTCOMES AND PROGNOSTIC FACTORS IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOMA AND BONE METASTASES.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

From: 1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv.

Objective: This institutional study sought to retrospectively evaluate disease progression and survival of patients with differentiated thyroid cancer (DTC) and bone metastases (BM) and to investigate variables predictive of better long-term outcomes.

Methods: The Rabin Medical Center Thyroid Cancer Registry was searched for patients with bone-metastatic DTC. Variables including patients' gender and age, pathology of the thyroid tumor and characteristics of BM were retrieved and analyzed in association with disease progression and mortality. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0465
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http://dx.doi.org/10.4158/EP-2018-0465DOI Listing
January 2019
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CLINICAL IMPACT OF NON-INVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES ON THE RISK OF MALIGNANCY IN THE BETHESDA SYSTEM FOR REPORTING THYROID CYTOPATHOLOGY: A META-ANALYSIS OF 14,153 RESECTED THYROID NODULES.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

From: 1Department of Pathology, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

Introduction It is still controversial as to how the reclassification of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk of malignancy (ROM) in The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). This meta-analysis was aimed to investigate the impact of NIFTP on the ROM in each TBSRTC category. Methods We accessed three electronic databases including PubMed, Web of Science, and Scopus to search for relevant data from January 2016 to July 2018. Read More

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http://dx.doi.org/10.4158/EP-2018-0506DOI Listing
January 2019
3 Reads