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    Pre-operative features of non-invasive follicular thyroid neoplasms with papillary-like nuclear features: An analysis of their cytological, Gene Expression Classifier and sonographic findings.
    Cytopathology 2017 Dec;28(6):488-494
    Department of Pathology & Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.
    Objective: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology.

    Methods: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1(st) April 2016 and 1(st) April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen. Read More

    Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.
    Oncol Lett 2017 Dec 26;14(6):6485-6496. Epub 2017 Sep 26.
    Division of Pathology Diagnostic Services, Cytology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
    Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. Read More

    Mixed subtype thyroid cancer: A surveillance, epidemiology, and end results database analysis.
    Oncotarget 2017 Oct 23;8(49):86556-86565. Epub 2017 Sep 23.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
    The prognosis of patients with mixed subtype thyroid cancer (MSTC) is unclear. The present study compared the prognoses of MSTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC) to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Read More

    HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid.
    Oncol Lett 2017 Dec 15;14(6):6505-6510. Epub 2017 Sep 15.
    Longnan Hospital of Daqing City, Daqing, Heilongjiang 163453, P.R. China.
    We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (papillary carcinoma group) and follicular differentiated thyroid carcinoma (follicular carcinoma group) to investigate the differences in expression of HBME-1. We further analyzed the correlation of the expression of HBME-1 in the papillary carcinoma group and the follicular carcinoma group with ultrasonic manifestation of thyroid. Read More

    Evaluating the projected surgical impact of reclassifying noninvasive encapsulated follicular variant of papillary thyroid cancer as noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Surgery 2017 Nov 13. Epub 2017 Nov 13.
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Institute for Technology Assessment, Boston, MA. Electronic address:
    Background: The reclassification of noninvasive encapsulated follicular variant of papillary thyroid cancer to noninvasive follicular thyroid neoplasm with papillary-like nuclear features will reduce nonefficacious and potentially harmful care. Reclassification is estimated in 18.6% of patients with papillary thyroid carcinoma; we aimed to quantify the implications of this change. Read More

    Endocr Pract 2017 Nov 16. Epub 2017 Nov 16.
    From: Department of Endocrinology, Diabetes and Metabolism.
    Objective: Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient.

    Methods: The literature search was performed through www. Read More

    Pathologic basis of the sonographic differences between thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Ultrasonography 2017 Aug 19. Epub 2017 Aug 19.
    Lenox Hill Radiology, New York, NY, USA.
    Ultrasonography is pivotal in triage thyroid biopsy in the era after the identification of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). This pictorial essay illustrates the pathologic basis of the sonographic features that distinguish NIFTP from thyroid cancers. In this study, we present the correlations of ultrasonography to ×1 histopathology to assess shape and margin characteristics. Read More

    Emerging entities in renal cell neoplasia: thyroid-like follicular renal cell carcinoma and multifocal oncocytoma-like tumours associated with oncocytosis.
    Pathology 2017 Nov 10. Epub 2017 Nov 10.
    Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.
    The list of accepted entities of renal cell neoplasia has burgeoned since the turn of the century through recognition of rare tumour types and the discovery of genetic mutations driving renal neoplasia syndromes. This growth has not finished and in this report we present examples of each of these types which were not included in the 2016 World Health Organization classification of renal neoplasia, but are candidates for inclusion in the next edition of the classification. Thyroid-like follicular renal cell carcinoma is a rare tumour type with a distinctive microscopic appearance resembling follicles of the thyroid gland. Read More

    New terminology-noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP) and its effect on the rate of malignancy at a single institution.
    Surgery 2017 Nov 7. Epub 2017 Nov 7.
    Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN.
    Background: The cytologic qualities of noninvasive follicular neoplasm with papillary-like nuclear features mimic papillary thyroid carcinoma (PTC) on fine-needle aspiration, leading to difficulty in distinguishing the 2 preoperatively. The aim of this study was to determine the impact of reclassification of noninvasive follicular neoplasm with papillary-like nuclear features at our practice.

    Methods: We searched 1,046 patient charts for those cases with preoperative cytology and subsequent follicular-variant papillary thyroid carcinoma diagnosis on resection. Read More

    Patients with papillary thyroid carcinoma associated with high stimulated serum calcitonin levels.
    Endocrinol Diabetes Metab Case Rep 2017 3;2017. Epub 2017 Nov 3.
    Departments of Endocrinology.
    Among various substances produced by C-cells, the most important one is calcitonin (CT) that is used for detection, post-operative follow-up and evaluation of individuals at risk of developing medullary thyroid carcinoma (MTC). However, the role of serum CT measurement in the evaluation of thyroid nodules has been widely discussed, and there is still no consensus about the role of CT in the initial evaluation of all thyroid nodules. Two patients with thyroid nodules whose fine-needle aspiration results were compatible with benign cytology besides having mildly elevated basal serum calcitonin levels were reported. Read More

    Cytomorphologic Diversity of Papillary Thyroid Carcinoma.
    J Cytol 2017 Oct-Dec;34(4):183-187
    Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    Introduction: Cytologic features of papillary thyroid carcinoma (PTC) have been extensively documented in literature. However, PTC variants can prove to be diagnostically challenging on fine needle aspiration cytology (FNAC).

    Aims: To study the FNAC features of PTC and its variants and explore the causes for misdiagnosis. Read More

    Surgical management for follicular variant of papillary thyroid carcinoma.
    Oncotarget 2017 Oct 16;8(45):79507-79516. Epub 2017 Jun 16.
    Department of Breast and Thyroid Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. China.
    Background And Aims: For most patients with follicular variant of papillary thyroid carcinoma (FVPTC), surgery is required, while the surgical management remains controversial. We aim to further understanding of treatment of FVPTC and to determine whether specific features could be identified for the decision of surgical strategy.

    Materials And Methods: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program database during 2003 and 2013. Read More

    Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.
    Lancet Diabetes Endocrinol 2017 Oct 25. Epub 2017 Oct 25.
    Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:
    Follicular thyroid cancer is the second most common differentiated thyroid cancer histological type and has been overshadowed by its more common counterpart-papillary thyroid cancer-despite its unique biological behaviour and less favourable outcomes. In this Review, we comprehensively review the literature on follicular thyroid cancer to provide an evidence-based guide to the management of these tumours, to highlight the lack of evidence behind guideline recommendations, and to identify changes and challenges over the past decades in diagnosis, prognosis, and treatment. We highlight that correct identification of cancer in indeterminate cytological samples is challenging and ultrasonographic features can be misleading. Read More

    Do patients with oxyphilic cell papillary thyroid carcinoma have a poor prognosis? Analysis of the surveillance, epidemiology, and end results database 2004-2013 with propensity score matching.
    Oncotarget 2017 Sep 18;8(44):77075-77085. Epub 2017 Aug 18.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
    The prognosis of oxyphilic cell papillary thyroid carcinoma (OCPTC) remains unclear. The aim of this study was to investigate the prognosis of OCPTC and provide a new perspective on treatment guidelines for these patients. We investigated a large cohort of DTC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. Read More

    Georgian Med News 2017 Oct(271):107-113
    Davit Tvildiani Medical University, Tbilisi, Georgia.
    Major problems haunt the physicians who need to delineate the best management strategy for their patients with thyroid nodule is the identification of the most aggressive cases, especially among papillary thyroid cancers, which would benefit from more aggressive therapy and follow up. Beyond its strong correlation with PTC, the BRAF mutation is well described to associate with poor prognosis. The aim of our study was to identify BRAF antibody expression in different hystotypes of the thyroid nodules and assessment of it expression according to the tumor aggressiveness. Read More

    Proof-of-concept Raman spectroscopy study aimed to differentiate thyroid follicular patterned lesions.
    Sci Rep 2017 Nov 2;7(1):14970. Epub 2017 Nov 2.
    Policlinico Universitario Campus Bio-medico, via Álvaro del Portillo 200, 00128, Roma, Italy.
    Inter-observer variability and cancer over-diagnosis are emerging clinical problems, especially for follicular patterned thyroid lesions. This challenge strongly calls for a new clinical tool to reliably identify neoplastic lesions and to improve the efficiency of differentiation between benign and malignant neoplasms, especially considering the increased diagnosis of small carcinomas and the growing number of thyroid nodules. In this study, we employed a Raman spectroscopy (RS) microscope to investigate frozen thyroid tissues from fourteen patients with thyroid nodules. Read More

    FNA diagnosis of poorly differentiated thyroid carcinoma. A review of the recent literature.
    Cytopathology 2017 Dec 2;28(6):467-474. Epub 2017 Nov 2.
    Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
    Poorly differentiated thyroid carcinoma (PDTC) is a follicular cell-derived tumour that was recognised as a distinct entity by the World Health Organisation in 2004. The natural history and pathological features of PDTC are reported to be intermediate between those of well-differentiated and undifferentiated (anaplastic) thyroid carcinomas. Preoperative identification of PDTC could facilitate better initial patient management in many cases, namely more extensive surgery, without any delay. Read More

    High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers.
    Crit Rev Clin Lab Sci 2017 Oct 30:1-12. Epub 2017 Oct 30.
    d Proteomic Unit , Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Universidad de Murcia , Murcia , Spain.
    The incidence of thyroid cancer (TC) - the most common endocrine malignancy - has been increasing sharply since the mid-1990s. The rate of TC incidence in both men and women has been faster than any other cancer. Both improved diagnoses (i. Read More

    Aberrant expression of CD20 in thyroid cancer and its clinicopathologic significance.
    Hum Pathol 2017 Oct 24. Epub 2017 Oct 24.
    Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. Electronic address:
    CD20 is the first line diagnostic marker of B-cells, which serves as the target of the therapeutic monoclonal antibodies in B-cell lymphomas and leukemias. Recently, aberrant CD20 expression has been described in a small series of papillary thyroid carcinomas (PTC). We aimed to evaluate CD20 immunoexpression and to perform clinicopathologic correlation in a large set of thyroid tumors, including a cohort of high-grade thyroid cancer. Read More

    Histologic Mimics of Basal Cell Carcinoma.
    Arch Pathol Lab Med 2017 Nov;141(11):1490-1502
    From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
    Context: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Read More

    Total Thyroidectomy for Thyroid Cancer Followed by Thyroid Storm due to Thyrotropin Receptor Antibody Stimulation of Metastatic Thyroid Tissue.
    Eur Thyroid J 2017 Sep 3;6(5):276-280. Epub 2017 Aug 3.
    Department of Endocrinology, Odense University Hospital, Odense, Denmark.
    Background: Graves disease (GD) is an autoimmune condition characterized by the presence of antibodies against the thyrotropin receptor (TRAB), which stimulate the thyroid gland to produce excess thyroid hormone. Theoretically, TRAB could stimulate highly differentiated thyroid cancer tissue and/or metastases to produce thyroid hormone.

    Case: A 68-year-old male, with weight loss and palpitations, was diagnosed with thyrotoxicosis. Read More

    Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line.
    Ann Clin Lab Sci 2017 Sep;47(5):572-580
    University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Aminoguanidine (AG), a diamine oxidase and a nitric oxide synthase inhibitor, was used in diabetes, thyroid follicular carcinoma, hepatocellular carcinoma, pancreatic cancer xenografts and in breast cancer research. The effects of AG on these pathologic conditions may be related to its regulatory effects on cell proliferation, angiogenesis, and expression of antioxidant enzymes. However, its role as pro and/or anti-oxidant affecting signaling and function in pancreatic tumor cell lines has not been studied. Read More

    Comparative effects of transforming growth factor beta isoforms on redox metabolism in thyroid cells.
    Mol Cell Endocrinol 2017 Oct 20. Epub 2017 Oct 20.
    CONICET, Argentina; Faculty of Medicine, University of Buenos Aires (UBA), Argentina. Electronic address:
    Introduction: Transforming growth factor beta (TGF-β) regulates thyroid function and growth. However, tumoral thyroid cells became resistant to this factor as they undifferentiated. Little is known about the effects of TGF-β isoforms. Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a review for pathologists.
    Mod Pathol 2017 Oct 20. Epub 2017 Oct 20.
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    The rising incidence of papillary thyroid carcinoma is linked in part to inclusion of noninvasive follicular variant of papillary thyroid carcinoma. Despite its designation as carcinoma, noninvasive follicular variant of papillary thyroid carcinoma appears to be exceptionally indolent, often over treated by current treatment practices. Additionally, criteria for diagnosis have historically been subjective and challenging. Read More

    Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy.
    Medicine (Baltimore) 2017 Oct;96(42):e8344
    aIstituto di Biostrutture e Bioimmagini, CNR bDipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli FedericoII cIRCCS - SDN, Napoli dMedicina Nucleare, IRCCS - CROB, Rionero in Vulture eDipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana," Università degli Studi di Salerno, Salerno, Italy.
    Background: To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg).

    Methods: Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9 ± 5 years after empiric RAI therapy were retrospectively analyzed. Read More

    An update on noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
    Curr Opin Oncol 2017 Oct 18. Epub 2017 Oct 18.
    Duke Health, Department of Pathology, Durham, North Carolina, USA.
    Purpose Of Review: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has been established in the literature as a clinically indolent tumor. Despite this, it was traditionally treated like all other PTCs. In an attempt to reduce overtreatment of this entity, a panel of experts reclassified this entity as noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP). Read More

    Reintroducing the Sodium-Iodide Symporter to Anaplastic Thyroid Carcinoma.
    Thyroid 2017 Nov 10. Epub 2017 Nov 10.
    1 Department of Internal Medicine IV, University Hospital of Munich , LMU Munich, Munich, Germany .
    Background: Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC.

    Methods: The study employed nanoparticle vectors (polyplexes) based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG) and coupled to the synthetic peptide GE11 as an epidermal growth factor receptor (EGFR)-specific ligand in order to target a NIS-expressing plasmid (LPEI-PEG-GE11/NIS) to EGFR overexpressing human thyroid carcinoma cell lines. Read More

    (18)F-fluorodeoxyglycose-avid thyroid incidentalomas: the importance of contextual interpretation.
    J Nucl Med 2017 Oct 12. Epub 2017 Oct 12.
    Peter MacCallum Cancer Centre, Australia.
    Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features in the pediatric age group.
    Cancer 2017 Oct 12. Epub 2017 Oct 12.
    Department of Pathology, Loyola University School of Medicine, Maywood, Illinois.
    Background: The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) to replace the noninvasive follicular variant of PTC. The objective of the current study was to evaluate previously diagnosed PTC in the pediatric population, reappraise it for NIFTP, and discuss the impact of NIFTP on the risk of malignancy (ROM) for each The Bethesda System for Reporting Thyroid Cytopathology category in the pediatric population. Read More

    Large (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
    PLoS One 2017 12;12(10):e0186242. Epub 2017 Oct 12.
    Department of Pathology, Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea.
    Background: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology.

    Methods: 632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included. Read More

    An upper cervical cord compression secondary to occult follicular thyroid carcinoma metastases successfully treated with multiple radioiodine therapies: A clinical case report.
    Medicine (Baltimore) 2017 Oct;96(41):e8215
    aDepartment of Nuclear Medicine bDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
    Rationale: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare.

    Patient Concerns: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months.

    Diagnosis: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling. Read More

    Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma.
    J Pathol Transl Med 2017 Oct 3. Epub 2017 Oct 3.
    Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
    Background: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis. Read More

    Regulation of NADPH oxidase NOX4 by delta iodolactone (IL-δ) in thyroid cancer cells.
    Mol Cell Endocrinol 2017 Oct 7. Epub 2017 Oct 7.
    Nuclear Biochemistry Division, Argentine National Atomic Energy Commission, Buenos Aires 1429, Argentina; CONICET, Argentina. Electronic address:
    Introduction: Iodine is not used only by the thyroid to synthesize thyroid hormones but also directly influences a number of thyroid parameters such as thyroid proliferation and function. Several iodinated lipids, biosynthesized by the thyroid, were postulated as intermediaries in the action of iodide. Among these, iodolactone (IL-δ) and 2-iodohexadecanal (2-IHDA) have shown to inhibit several thyroid parameters. Read More

    Sunitinib in the treatment of thyroid cancer.
    Curr Med Chem 2017 Oct 6. Epub 2017 Oct 6.
    Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa. Italy.
    Background: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors. Read More

    Altered Epigenetic Mechanisms in Thyroid Cancer Subtypes.
    Mol Diagn Ther 2017 Oct 6. Epub 2017 Oct 6.
    Cellular and Molecular Endocrine Research Center (CMERC), Research Institute for Endocrine Sciences of Shahid Beheshti University of Medical Sciences, 19395-4763, Tehran, Iran.
    Thyroid carcinoma (TC) is the most frequent malignant neoplasm of the endocrine system. Molecular methods for diagnosis of invasive thyroid disease can be effectively adopted. Epigenetic factors play an important role in the diversity patterns of gene expression and the phenotypic and biological characteristics of TC subtypes. Read More

    ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway.
    Oncotarget 2017 Sep 29;8(40):67769-67781. Epub 2017 Jun 29.
    Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
    We previously reported that ABI3 expression is lost in follicular thyroid carcinomas and its restoration significantly inhibited cell growth, invasiveness, migration, and reduced tumor growth in vivo. The mechanistic basis by which ABI3 exerts its tumor suppressive effects is not fully understood. In this study, we show that ABI3 is a phosphoprotein. Read More

    cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis.
    Diagn Pathol 2017 Oct 3;12(1):71. Epub 2017 Oct 3.
    Cleveland Clinic, Department of Pathology and Laboratory Medicine, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.
    Background: cMYC regulates approximately 15% of human genes and is involved in up to 20% of all human cancers. Reports discussing cMYC protein expression in thyroid carcinomas are limited, with controversies pertaining to cMYC expression patterns noted in the literature. The aims of the current study were to clarify patterns and intensities of cMYC expression in follicular cell-derived thyroid carcinomas across a spectrum of cancer morphologies and disease aggressivities, to correlate cMYC with BRAF(V600E) expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas. Read More

    Harefuah 2017 Sep;156(9):568-572
    Otolaryngology, Head and Neck Surgery, Rambam Medical Campus, Haifa, Israel.
    Aims: We aimed to better define the most appropriate therapeutic protocol for this type of tumor.

    Background: The incidence of well-differentiated thyroid carcinoma is rising and the mortality from the disease remains low for patients with early disease. Nevertheless, the survival of patients with advanced disease has not improved during the last four decades and a controversy still exists in the literature regarding the optimal treatment in patients with locally advanced (T4) differentiated thyroid carcinoma. Read More

    Patterns of Thyroid Cancers in Southeastern Nigeria: A 15 Year Histopathologic Review (2000-2014).
    J Clin Diagn Res 2017 Aug 1;11(8):EC16-EC19. Epub 2017 Aug 1.
    Senior Lecturer/Consultant, Department of Radiation Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria.
    Introduction: Thyroid Cancer (TC) continues to be the most common endocrine cancer with a worldwide increase in incidence over the last three decades. This trend has been reported in all continents except Africa, where detection is adjudged to be insufficient, making it imperative for us to re-evaluate the patterns in our environment.

    Aim: To determine the patterns of TCs in Southeastern Nigeria. Read More

    EIF1AX Mutation in a Patient with Hürthle Cell Carcinoma.
    Endocr Pathol 2017 Sep 30. Epub 2017 Sep 30.
    Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street 6th Floor, Philadelphia, PA, 19107, USA.
    The EIF1AX gene is a novel cancer gene that has been reported in the tumorigenesis of papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, and anaplastic thyroid carcinoma. A 71-year-old woman presented with a right thyroid mass, which was follicular neoplasm on cytology. The fine needle aspirate of the nodule was examined by next-generation sequencing and found to harbor EIF1AX and TP53 mutations. Read More

    Management of the central compartment in differentiated thyroid carcinoma.
    Eur J Surg Oncol 2017 Sep 13. Epub 2017 Sep 13.
    The Clayman Thyroid Surgery and Thyroid Cancer Center, Tampa, FL, USA. Electronic address:
    Management of differentiated thyroid carcinoma (DTC) is gradually evolving with considerations of de-escalation of treatment and/or active surveillance in a significant proportion of patients on the basis of an improved understanding of the long-term disease and functional outcomes from both surgical and non-surgical approaches. This is fueled by improved risk stratification using clinicopathologic prognostic factors as determined through high resolution ultrasound and fine needle aspiration cytology. This paper discusses general recommendations for preoperative decision-making in the management of the central compartment in DTC with particular reference to micropapillary thyroid carcinoma and encapsulated follicular variant papillary thyroid carcinoma. Read More

    Mitochondrial DNA "common deletion" in post-FNA infarcted oncocytic thyroid tumors.
    Hum Pathol 2017 Sep 26. Epub 2017 Sep 26.
    Department of Oncology, University of Torino, Città della Salute e della Scienza Hospital, Via Santena 7, 10126 Torino, Italy.
    Thyroid fine needle aspiration (FNA) can rarely induce morphological changes potentially hindering the histopathological diagnosis, especially in Hurthle cell tumors (HCT), which may easily undergo post-FNA infarction or necrosis. HCTs contain mitochondrion (mt)-rich cells that may bear mtDNA mutations, the most frequent being the so-called "common deletion" (CD). The aim of this study was to determine the presence and extent of the mtDNA CD in a series of thyroid HCT that underwent extensive infarction following FNA procedure, in comparison with a control series of HCT lacking post-FNA ischemic/hemorrhagic alterations. Read More

    Unilateral adrenal mass as the sole initial manifestation of differentiated thyroid cancer.
    BMJ Case Rep 2017 Sep 27;2017. Epub 2017 Sep 27.
    Department of Endocrinology and Metabolism, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India.
    Unilateral adrenal metastases without disseminated disease has rarely been reported in differentiated thyroid carcinoma (DTC). A 72-year-old female presented with vague abdominal discomfort and loss of appetite of 2 months duration. She had undergone left hemithyroidectomy for a benign thyroid nodule 18 years ago. Read More

    Ultrasonic diagnosis for thyroid Hürthle cell tumor.
    Cancer Biomark 2017 Sep;20(3):235-240
    Department of Ultrasound, Peking University First Hospital, Beijing 100034, China.
    Objective: This study aims to evaluate the diagnostic value of ultrasound in thyroid Hürthle cell tumors.

    Methods: A retrospective analysis was carried out on 27 patients with thyroid Hürthle cell tumors, in terms of the size, shape, boundary, echo, aspect ratio, cystic degeneration, calcification, peripheral halo sign and blood supply of the tumor, through surgical pathological validation. Then, these were compared with postoperative pathological results. Read More

    Follicular adenoma in ectopic thyroid. A case-report.
    Int J Surg Case Rep 2017 14;40:94-96. Epub 2017 Sep 14.
    Hospital of Cava de' Tirreni, Università degli studi di Salerno, Italy. Electronic address:
    Introduction: The term ectopic thyroid refers to the presence of thyroid tissue located far from its usual anatomic placement and with no vascular connection to the main gland. The presence of swelling in atypical locations is diagnostically differentiated from other pathologies like pleomorphic adenoma or carcinoma, inflammatory lesions like sialadenitis, neurogenic tumors, paraganglioma, fibrolipoma and lymphadenopaties of diverse etiologies.

    Presentation Of Case: Here we present the case of a submandibular ectopic thyroid in a 67year old woman. Read More

    Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).
    Cancer 2017 Sep 20. Epub 2017 Sep 20.
    Department of Anatomic Pathology and Histology, "A. Gemelli" University Polyclinic Foundation, University Rome, Italy.
    Background: The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk of malignancy (ROM) mostly in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories. In this multi-institutional, retrospective study, the authors investigated variations in the impact of an NIFTP diagnosis on the associated ROM for each TBSRTC category with an emphasis on the influence of pathologist and institutional diagnostic thresholds on the ROM.

    Methods: Baseline data on cytology and histology diagnostic categories were collected over a 3-year period at 3 academic center hospitals (institutions A, B, and C). Read More

    Molecular genotyping of noninvasive encapsulated follicular variant of papillary thyroid carcinoma.
    Histopathology 2017 Sep 20. Epub 2017 Sep 20.
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.
    Aim: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has been managed as low-risk malignancy. Recently, a proposal was made to reclassify this tumor type as a premalignant lesion and rename it noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). However, a comprehensive study on molecular genotype-phenotype correlations of encapsulated FVPTC is lacking. Read More

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